diff --git a/.opencode/opencode.json b/.opencode/opencode.json new file mode 100644 index 00000000..a1037f78 --- /dev/null +++ b/.opencode/opencode.json @@ -0,0 +1,9 @@ +{ + "$schema": "https://opencode.ai/config.json", + "skills": { + "paths": [ + ".opencode/skills", + "C:/Users/Lin/ponytail/skills" + ] + } +} diff --git a/_amb_detail.py b/_amb_detail.py new file mode 100644 index 00000000..227802c0 --- /dev/null +++ b/_amb_detail.py @@ -0,0 +1,16 @@ +import json; from pathlib import Path +audit=Path('audit') +papers=['6QNRHRKX','7S5ZEVSK','8K39NHUQ','5DIEAVPW','RKSLQRIM'] +for k in papers: + fp=audit/k/'figure_table_ownership_summary.json' + if not fp.exists(): continue + d=json.load(open(fp,'r',encoding='utf-8')) + print(f'\n=== {k} ===') + matched=d['figures']['matched_count']; amb=d['figures']['ambiguous_count'] + print(f'fig={matched}/{matched+amb}') + for a in d['figures'].get('ambiguous',[]): + fn=a.get('figure_number','?') + ca=len(a.get('candidate_asset_ids',[])) + hr=a.get('hold_reason','?') + pg=a.get('page','?') + print(f' Fig {fn} p{pg}: {ca}cand {hr}') diff --git a/_chk_pdf.py b/_chk_pdf.py new file mode 100644 index 00000000..ab01c63e --- /dev/null +++ b/_chk_pdf.py @@ -0,0 +1,23 @@ +import json +from pathlib import Path + +for paper in ['RKSLQRIM', '6DIINFHX', 'GTRPMM56', 'KIX7SKXQ']: + meta_path = Path(f'D:/L/OB/Literature-hub/System/PaperForge/ocr/{paper}/raw/source_metadata.json') + if not meta_path.exists(): + print(f'{paper}: NO METADATA') + continue + meta = json.load(open(meta_path,'r',encoding='utf-8')) + src = meta.get('source_pdf','') + exists = Path(src).exists() if src else False + print(f'{paper}: pdf={src[:60]}... exists={exists}') + + # Check backfill status on structured blocks + blk_path = Path(f'D:/L/OB/Literature-hub/System/PaperForge/ocr/{paper}/structure/blocks.structured.jsonl') + if blk_path.exists(): + lines = [json.loads(l) for l in blk_path.read_text(encoding='utf-8').strip().split('\n') if l.strip()] + empty_us = [b for b in lines if b.get('role','')=='unknown_structural' and len(str(b.get('text','') or ''))==0] + recovered = sum(1 for b in lines if b.get('_ocr_raw_status')=='missing_text_recovered') + print(f' empty unknown_structural: {len(empty_us)}, recovered: {recovered}') + if empty_us: + b = empty_us[0] + print(f' sample: p{b.get("page")}:{b.get("block_id")} raw_label={b.get("raw_label")} spans={len(b.get("span_metadata",[]))} status={b.get("_ocr_raw_status")}') diff --git a/_chk_vfs_p11.py b/_chk_vfs_p11.py new file mode 100644 index 00000000..579086df --- /dev/null +++ b/_chk_vfs_p11.py @@ -0,0 +1,36 @@ +import json +with open('D:/L/OB/Literature-hub/System/PaperForge/ocr/VFS8CBW2/structure/blocks.structured.jsonl','r',encoding='utf-8') as f: + lines = [json.loads(l) for l in f.read().strip().split('\n') if l.strip()] +p11 = [b for b in lines if b.get('page')==11] +p10 = [b for b in lines if b.get('page')==10] +p12 = [b for b in lines if b.get('page')==12] + +print('=== PAGE 10 ===') +for b in p10: + bid = b['block_id'] + role = b.get('role','?') + txt = str(b.get('text','') or '')[:80] + bbox = b.get('bbox',[]) + print(f' id={bid:3d} role={role:25s} text_len={len(txt):4d} bbox={bbox}') + if txt: + print(f' [{txt}]') + +print('\n=== PAGE 11 ===') +for b in p11: + bid = b['block_id'] + role = b.get('role','?') + txt = str(b.get('text','') or '')[:80] + bbox = b.get('bbox',[]) + print(f' id={bid:3d} role={role:25s} text_len={len(txt):4d} bbox={bbox}') + if txt: + print(f' [{txt}]') + +print('\n=== PAGE 12 ===') +for b in p12: + bid = b['block_id'] + role = b.get('role','?') + txt = str(b.get('text','') or '')[:80] + bbox = b.get('bbox',[]) + print(f' id={bid:3d} role={role:25s} text_len={len(txt):4d} bbox={bbox}') + if txt: + print(f' [{txt}]') diff --git a/_figmap.json b/_figmap.json new file mode 100644 index 00000000..ab904e50 --- /dev/null +++ b/_figmap.json @@ -0,0 +1,5 @@ +Traceback (most recent call last): + File "D:\L\Med\Research\99_System\LiteraturePipeline\github-release\.opencode\skills\paperforge-development\scripts\audit_helpers.py", line 363, in + "body_find_noise": body_find_noise, + ^^^^^^^^^^^^^^^ +NameError: name 'body_find_noise' is not defined diff --git a/_final_stats.py b/_final_stats.py new file mode 100644 index 00000000..0218670e --- /dev/null +++ b/_final_stats.py @@ -0,0 +1,11 @@ +import json; from pathlib import Path +audit=Path('audit') +papers=sorted([d.name for d in audit.iterdir() if (d/'figure_table_ownership_summary.json').exists()]) +total_fm=0; total_fa=0 +for k in papers: + d=json.load(open(audit/k/'figure_table_ownership_summary.json','r',encoding='utf-8')) + fm=d['figures']['matched_count']; fa=d['figures']['ambiguous_count'] + tm=d['tables']['matched_count']; ta=d['tables']['ambiguous_count'] + total_fm+=fm; total_fa+=fa + print(f'{k:<10} fig={fm}/{fm+fa} tbl={tm}/{tm+ta}') +print(f'\nTotal: {total_fm}/{total_fm+total_fa} = {total_fm/(total_fm+total_fa)*100:.0f}%' if total_fm+total_fa else '') diff --git a/_test_6qnr.py b/_test_6qnr.py new file mode 100644 index 00000000..cc3cbc72 --- /dev/null +++ b/_test_6qnr.py @@ -0,0 +1,23 @@ +import json, sys +sys.path.insert(0, '.') +from paperforge.worker.ocr_figures import build_figure_inventory + +for paper in ['6QNRHRKX', 'KIX7SKXQ']: + with open(f'D:/L/OB/Literature-hub/System/PaperForge/ocr/{paper}/structure/blocks.structured.jsonl','r',encoding='utf-8') as f: + blocks = [json.loads(l) for l in f.read().strip().split('\n') if l.strip()] + result = build_figure_inventory(blocks) + mt = len(result.get('matched_figures', [])) + amb = len(result.get('ambiguous_figures', [])) + print(f'{paper}: matched={mt} ambiguous={amb}') + for a in result.get('ambiguous_figures',[]): + fn = a.get('figure_number','?') + hr = a.get('hold_reason','?') + ca = len(a.get('candidates',[])) + pg = a.get('page','?') + print(f' Fig {fn} p{pg}: {ca}cand {hr}') + for m in result.get('matched_figures',[]): + fn = m.get('figure_number','?') + pg = m.get('page') + n = len(m.get('matched_assets',[])) + fl = m.get('flags',[]) + print(f' MATCHED Fig {fn} p{pg}: {n} assets {fl}') diff --git a/audit/23T2B8ZX/audit_report.json b/audit/23T2B8ZX/audit_report.json new file mode 100644 index 00000000..24783c19 --- /dev/null +++ b/audit/23T2B8ZX/audit_report.json @@ -0,0 +1,500 @@ +{ + "paper_key": "23T2B8ZX", + "mode": "high-risk", + "status": "READY", + "focus": [], + "artifact_fingerprint": { + "result_json_hash": "sha256:c32fd65809059c4d60a58c03dc0214b7cd98296e1833b4e4ad6d3541f7126f4f", + "meta_json_hash": "sha256:50e42ca68bf8335f835c284c730e287ca2e0cd779b8c68dce01cd1325cde210c", + "blocks_raw_hash": "sha256:3d9d3a7da7accaafef2001d26e28854468ff728eb2009df6d61f54491ad60d66", + "structured_blocks_hash": "sha256:8b229bfea197ea7c8b79c8be9b043750705529649dcfcbd0ec57490173bb693f", + "document_structure_hash": "sha256:308f35126bbd7fc9911bee46e8ba6b987a3437e767078b37de6a6e2e75527cfd", + "figure_inventory_hash": "sha256:75ad4c0d43cdf378683a83770400df9ca8ea36b29e247dec9639066a4abbe483", + "table_inventory_hash": "sha256:141154eeda3bec84c7ff75f0212677ec09f8f5022d61ac0fbdfd33d2156545c9", + "reader_figures_hash": "sha256:c4d23553428efdfb646416f775b8746e58bc9d94f23ec1b12a17eaff2f618652", + "resolved_metadata_hash": "sha256:56d2d3e6933b78ec7a2f48d0cb9f511bccb02dc78b22ad0b100a3c93f71476a8", + "fulltext_hash": "sha256:9394031ade6bd3e9b8cf9700fac1b40f895d9b6565b1e13fcbea3c1a9d9893fd", + "block_trace_hash": "sha256:073d5b641165df47d4f65e03ee466aac966ded767d1b2e0710d520922c57c068", + "annotated_pages": { + "page_001.png": "sha256:aae0ab6983ee4640bd147829411a6ee4334ddaeed09590aa3b837a5386855c96", + "page_002.png": "sha256:4bd9a08d9b6e077b2236e17c65bbaad285380f2863ffc203224857a89a070cda", + "page_003.png": "sha256:5f972f1fec848d38a758c6976628e87c98a454049a01f700a7027def9230260a", + "page_004.png": "sha256:37bafcf6679ff384b494abd9663e47601363bce3144802af1bc3a48354a47dec", + "page_005.png": "sha256:59a2e78affac040c56f8effec28e7655731355951c7abdb718b2d2a5e4b4580a", + "page_006.png": "sha256:1661ffe5eaba390f415694d88d7d3866a3cdeebe342bb3d631173261da6cbcea", + "page_007.png": "sha256:c6f35d4c383bf1e02a630af47f56e1f666e19ee5fd1a2a68fa30ebd529b652cd" + } + }, + "artifact_freshness": { + "missing": [], + "mismatches": [ + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" + ], + "annotated_pages_rendered": [ + "page_001.png", + "page_002.png", + "page_003.png", + "page_004.png", + "page_005.png", + "page_006.png", + "page_007.png" + ] + }, + "reviewed_pages": [ + 1, + 2, + 3, + 4, + 5, + 6 + ], + "reviewed_blocks": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:8", + "p2:9", + "p2:10", + "p2:11", + "p2:12", + "p2:13", + "p2:14", + "p2:15", + "p2:16", + "p2:17", + "p2:18", + "p2:19", + "p2:20", + "p2:21", + "p2:22", + "p2:23", + "p2:24", + "p2:25", + "p2:26", + "p2:27", + "p2:28", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:4", + "p3:5", + "p3:6", + "p3:7", + "p3:8", + "p3:9", + "p3:10", + "p3:11", + "p3:12", + "p3:13", + "p3:14", + "p3:15", + "p3:16", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p4:10", + "p4:11", + "p4:12", + "p4:13", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p5:11", + "p5:12", + "p5:13", + "p5:14", + "p5:15", + "p5:16", + "p5:17", + "p5:18", + "p5:19", + "p6:0", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p6:5", + "p6:6", + "p6:7", + "p6:8", + "p6:9", + "p6:10", + "p6:11", + "p6:12", + "p6:13", + "p6:14", + "p6:15", + "p6:16", + "p6:17" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:7", + "p1:8", + "p1:16", + "p1:18", + "p2:1", + "p2:2", + "p2:5", + "p2:7", + "p3:0", + "p3:1", + "p4:1", + "p4:2", + "p5:0", + "p5:1", + "p5:3" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/23T2B8ZX/audit_report.md b/audit/23T2B8ZX/audit_report.md new file mode 100644 index 00000000..76bedb48 --- /dev/null +++ b/audit/23T2B8ZX/audit_report.md @@ -0,0 +1,37 @@ +# OCR Truth Audit Report - 23T2B8ZX + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 3, 4, 5, 6] +- Reviewed blocks: 117 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/23T2B8ZX/audit_scope.json b/audit/23T2B8ZX/audit_scope.json new file mode 100644 index 00000000..68ec044f --- /dev/null +++ b/audit/23T2B8ZX/audit_scope.json @@ -0,0 +1,624 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 3, + 4, + 5, + 6 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p2:1", + "p2:5", + "p2:7", + "p3:3", + "p4:3", + "p4:5", + "p5:3", + "p5:4", + "p5:9", + "p5:10", + "p5:14", + "p6:1", + "p6:7", + "p6:14", + "p6:15", + "p6:16", + "p6:17" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + 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+1,1,header_image,,"[106.0, 103.0, 216.0, 199.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,header,ARTICLE IN PRESS,"[419.0, 9.0, 799.0, 51.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,"JOURNAL OF +SHOULDER AND +ELBOW +SURGERY","[949.0, 79.0, 1110.0, 175.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,header,www.elsevier.com/locate/ymse,"[911.0, 191.0, 1115.0, 211.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,5,text,ORIGINAL ARTICLE,"[103.0, 248.0, 301.0, 276.0]",authors,0.6,"[""page-1 initial-lastname author byline: ORIGINAL ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,6,doc_title,Predictive findings on magnetic resonance imaging in patients with symptomatic acromioclavicular osteoarthritis,"[101.0, 309.0, 826.0, 447.0]",paper_title,0.8,"[""page-1 zone title_zone: Predictive findings on magnetic resonance imaging in patient""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text,"Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $ ^{a} $, Robin E. Westerbeek, MD $ ^{c} $, Rosalie P.H. Derks, MD $ ^{c} $, Ellie B.M. Landman, PhD $ ^{a} $, Cornelis T. Koorevaar, MD, PhD","[102.0, 475.0, 1076.0, 542.0]",authors,0.8,"[""page-1 zone author_zone: Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,8,text," $ ^{a} $Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, Deventer, The Netherlands + $ ^{b} $Department of Orthopaedic Surgery, University Medical Center, University of Groningen","[101.0, 570.0, 1069.0, 646.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $Department of Orthopaedic Surgery and Traumatology, ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,9,abstract,Background: A magnetic resonance imaging (MRI) scan of the shoulder can have added value in diagnosing symptomatic osteoarthritis of the acromioclavicular (AC) joint. Specific MRI signs have been reco,"[113.0, 684.0, 880.0, 774.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,abstract,Methods: The MRI scans of 70 patients with symptomatic AC osteoarthritis were compared with those of 70 patients with subacromial pain syndrome and no clinical signs of symptomatic AC osteoarthritis. ,"[114.0, 774.0, 881.0, 887.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,11,abstract,"Results: The presence of inferior osteophytes, bone marrow edema, impression on the supraspinatus, and inferior joint distension was individually associated with symptomatic AC osteoarthritis. Bone ma","[114.0, 885.0, 880.0, 1038.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,12,abstract,"Conclusion: We identified predictive MRI signs in patients with symptomatic AC osteoarthritis. These findings, including bone marrow edema, inferior joint distension, and impression on the supraspinat","[114.0, 1038.0, 879.0, 1126.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,13,text,"Level of evidence: Level IV; Case-Control Design; Diagnostic Study +© 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.","[115.0, 1125.0, 731.0, 1171.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Level of evidence: Level IV; Case-Control Design; Diagnostic""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,14,text,Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow edema; impression on musculus supraspinatus; predictive findings,"[114.0, 1176.0, 879.0, 1221.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,15,footnote,"Approval of this study was obtained from the regional Medical Ethical Committee (METC Isala, No. 15.0222).","[101.0, 1303.0, 833.0, 1324.0]",footnote,0.7,"[""footnote label: Approval of this study was obtained from the regional Medica""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,16,footnote," $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, PO Box 5001, NL-7400 GC Deventer, The Netherlands.","[102.0, 1321.0, 1116.0, 1366.0]",footnote,0.7,"[""footnote label: $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department o""]",footnote,0.7,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,17,footnote,E-mail address: ejdveen@gmail.com (E.J.D. Veen).,"[126.0, 1365.0, 464.0, 1385.0]",footnote,0.7,"[""footnote label: E-mail address: ejdveen@gmail.com (E.J.D. Veen).""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,18,footer,1058-2746/$ - see front matter © 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved. https://doi.org/10.1016/j.jse.2018.01.001,"[102.0, 1407.0, 875.0, 1449.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,0,number,2,"[75.0, 65.0, 88.0, 85.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,doc_title,ARTICLE IN PRESS,"[388.0, 10.0, 767.0, 51.0]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,short_fragment,False,True +2,2,header,E.J.D. Veen et al.,"[937.0, 65.0, 1081.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,3,text,"Degeneration of the acromioclavicular (AC) joint, with joint space narrowing and osteophyte formation, is part of the normal aging process. $ ^{[10,19]} $ In most of the general population, osteoarthr","[70.0, 109.0, 558.0, 373.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"The diagnosis of symptomatic AC osteoarthritis is made by an accurate history, clinical examination, and additional radiodiagnostic imaging studies. Previous studies have debated the accuracy and reli","[70.0, 374.0, 557.0, 541.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,Previous research has shown that advanced signs of degeneration in the AC joint seen on the MRI scan are correlated with symptoms and that bone marrow edema is only observed in patients with symptomat,"[70.0, 542.0, 558.0, 685.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Previous research has shown that advanced signs of degenerat""]",authors,0.8,body_zone,body_like,none,False,True +2,6,text,The aim of this study was to identify predictive MRI signs in patients with symptomatic AC osteoarthritis. We hypothesized that specific MRI signs would be found in patients with symptomatic AC osteoa,"[70.0, 685.0, 558.0, 783.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,Materials and methods Design,"[72.0, 808.0, 310.0, 887.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Materials and methods Design""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,False,True +2,8,footer,,"[72.0, 860.0, 142.0, 887.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,9,text,"This study had a retrospective, case-control, diagnostic study design and was conducted in a general teaching hospital with a specialized shoulder unit.","[70.0, 911.0, 557.0, 978.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,Study population,"[71.0, 1005.0, 238.0, 1031.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Study population""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,11,text,A total of 140 patients were selected from the electronic patient files: 70 consecutive patients with clinical isolated symptomatic AC osteoarthritis (group 1) and 70 consecutive patients with chronic,"[70.0, 1054.0, 558.0, 1187.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,text,Patients in both groups were recruited from our outpatient department: group 1 in 2009 to 2014 and group 2 in 2012 to 2014. The inclusion criteria for group 1 were pain localized in the AC joint that ,"[70.0, 1188.0, 558.0, 1452.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,text,"the AC joint and a positive cross-body adduction test. The exclusion +criteria for both groups were rheumatoid arthritis, a history of shoul- +der surgery or fracture, glenohumeral osteoarthritis, ruptu","[594.0, 109.0, 1084.0, 198.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,text,All patients with shoulder pain were reviewed in our shoulder unit by 2 experienced shoulder surgeons using a standard protocol for clinical history and clinical examination. Data were collected in a ,"[595.0, 198.0, 1085.0, 375.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,paragraph_title,Signs on MRI,"[598.0, 404.0, 726.0, 431.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Signs on MRI""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,short_fragment,True,True +2,16,text,"All MRI scans were performed 2 to 3 weeks after the outpatient visit in our hospital on a 1.5-T Signa HDx TwinSpeed1 MRI system (General Electric, Milwaukee, WI, USA). The shoulder was placed in a ded","[596.0, 454.0, 1084.0, 653.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,17,text,"On the basis of previous research and clinical experience, 7 variables were evaluated on the MRI scans:","[595.0, 654.0, 1083.0, 697.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,18,text,"1. AC joint space narrowing: minimal space between the clavicle and acromion on axial images, with the cutoff value for joint space narrowing set at 2 mm","[615.0, 717.0, 1084.0, 783.0]",body_paragraph,0.6,"[""reference-like pattern: 1. AC joint space narrowing: minimal space between the clavi""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,19,text,2. AC joint effusion: fluid-equivalent signal in the AC joint space,"[614.0, 784.0, 1084.0, 805.0]",body_paragraph,0.6,"[""reference-like pattern: 2. AC joint effusion: fluid-equivalent signal in the AC join""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,20,text,3. Subchondral bone marrow edema of the distal clavicle and/or medial acromion: hyperintense signal from cranial to caudal on fat-saturated T2-weighted images and hypointense signal on T1-weighted ima,"[615.0, 800.0, 1083.0, 894.0]",body_paragraph,0.6,"[""reference-like pattern: 3. Subchondral bone marrow edema of the distal clavicle and/""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,21,text,4. AC osteolysis: lytic bone lesion with cortical destruction of the distal clavicle,"[614.0, 894.0, 1084.0, 937.0]",body_paragraph,0.6,"[""reference-like pattern: 4. AC osteolysis: lytic bone lesion with cortical destructio""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,22,text,"5. AC inferior osteophytes: inferior osteophyte, 2 mm or longer (length measured from a horizontal line on the original undersurface of the clavicle on coronal images, Fig. 1).","[614.0, 938.0, 1084.0, 1004.0]",body_paragraph,0.6,"[""reference-like pattern: 5. AC inferior osteophytes: inferior osteophyte, 2 mm or lon""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,23,text,"6. Inferior AC joint distension: distal protrusion of the AC joint, 3 mm or longer (measured from a horizontal line on the original undersurface of the clavicle on sagittal or coronal images, Fig. 1).","[615.0, 1004.0, 1084.0, 1092.0]",body_paragraph,0.6,"[""reference-like pattern: 6. Inferior AC joint distension: distal protrusion of the AC""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,24,text,"7. Impression on the supraspinatus due to the AC joint: 3 scores (on sagittal T1 or proton density sequences): (1) normal fat between AC joint and supraspinatus, (2) no fat between AC joint and supras","[615.0, 1092.0, 1084.0, 1203.0]",body_paragraph,0.6,"[""reference-like pattern: 7. Impression on the supraspinatus due to the AC joint: 3 sc""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,25,text,"To enhance interpretation of the findings on MRI in clinical practice, variables were expressed dichotomously. Cutoff values for joint space narrowing, inferior osteophytes, and joint distension were ","[594.0, 1223.0, 1084.0, 1313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,26,paragraph_title,Statistical analysis Demographic and clinical characteristics,"[596.0, 1341.0, 948.0, 1405.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical analysis Demographic and clinical characteristic""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,27,footer,,"[596.0, 1381.0, 948.0, 1405.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,28,text,"The demographic and clinical characteristics were presented as proportion, mean (standard deviation), or median (interquartile range)","[595.0, 1407.0, 1084.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,ARTICLE IN PRESS,"[420.0, 11.0, 798.0, 50.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,Signs on MRI for AC osteoarthritis,"[104.0, 64.0, 386.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,number,3,"[1100.0, 67.0, 1113.0, 85.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,3,image,,"[118.0, 115.0, 575.0, 489.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,"Figure 1 Measurement of inferior osteophyte (O) and inferior joint distension (JD) on coronal image from magnetic resonance imaging scan. A, acromion; Cl, clavicle; SS, supraspinatus; H, humerus.","[101.0, 505.0, 589.0, 573.0]",figure_caption,0.92,"[""figure_title label: Figure 1 Measurement of inferior osteophyte (O) and inferior""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,5,text,in the case of a skewed distribution. Differences between patients with symptomatic AC osteoarthritis and the control group were tested using independent-samples t tests for continuous variables or $,"[102.0, 599.0, 591.0, 689.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,Analysis of MRI predictors for symptomatic AC osteoarthritis,"[101.0, 713.0, 505.0, 760.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Analysis of MRI predictors for symptomatic AC osteoarthritis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,7,text,Univariate logistic regression analyses were performed to evaluate the association between each of the MRI findings individually and symptomatic AC osteoarthritis. MRI findings showing a significant a,"[101.0, 762.0, 591.0, 1202.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,paragraph_title,Intraobserver and interobserver variability,"[102.0, 1225.0, 510.0, 1250.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,9,text,"Intraobserver and interobserver variability was calculated for the findings of the final multivariate logistic regression model. This was done by calculating the k value, using data from 20 patients f","[101.0, 1274.0, 590.0, 1452.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"variability was evaluated by comparing the values within the panel +of judges; intraobserver variability was evaluated by scoring the vari- +ables twice by the panel of judges on 2 days in different wee","[626.0, 110.0, 1116.0, 244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,Results Demographic characteristics,"[628.0, 265.0, 901.0, 345.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Results Demographic characteristics""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,12,footer,,"[628.0, 318.0, 901.0, 345.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +3,13,text,"Figure 3 shows a flow diagram of study enrollment. Between 2009 and 2014, 126 consecutive patients presented with clinical symptoms of AC osteoarthritis. To include only patients with isolated symptom","[625.0, 369.0, 1116.0, 850.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 3 shows a flow diagram of study enrollment. Between 2""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +3,14,text,Complete demographic and clinical data for both groups are shown in Table I. Demographic parameters were comparable between the 2 groups. Significant differences were found between groups in the size ,"[626.0, 850.0, 1116.0, 1018.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,paragraph_title,MRI characteristics,"[628.0, 1040.0, 815.0, 1065.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: MRI characteristics""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +3,16,text,"Because bone marrow edema was found only in patients with symptomatic AC osteoarthritis and because osteolysis was not found in any patients, these variables were not included in the regression analys","[625.0, 1091.0, 1117.0, 1454.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,4,"[74.0, 66.0, 89.0, 86.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,ARTICLE IN PRESS,"[388.0, 11.0, 767.0, 51.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,header,E.J.D. Veen et al.,"[936.0, 64.0, 1081.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,image,,"[158.0, 115.0, 1001.0, 352.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,4,figure_title,"Figure 2 Compression of supraspinatus on sagittal images from magnetic resonance imaging scans: no contact (A), adjacent (B), and impression (C). A, acromion; Cl, clavicle; SS, supraspinatus; H, humer","[71.0, 369.0, 1085.0, 415.0]",figure_caption,0.92,"[""figure_title label: Figure 2 Compression of supraspinatus on sagittal images fro""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,5,image,,"[156.0, 444.0, 999.0, 898.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,6,figure_title,"Figure 3 Flowchart of study enrollment. AC, acromioclavicular.","[332.0, 923.0, 823.0, 946.0]",figure_caption,0.92,"[""figure_title label: Figure 3 Flowchart of study enrollment. AC, acromioclavicula""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,7,text,"confidence interval [CI], 3.53 to 36.44; P < .001 and joint distension (odds ratio, 3.38; 95% CI, 1.25 to 9.13; P = .016).","[70.0, 985.0, 556.0, 1033.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"The Hosmer-Lemeshow test for goodness of fit of the model including these 2 variables was performed including only those patients without bone marrow edema and was not significant $ (P = .963) $, ind","[69.0, 1034.0, 558.0, 1251.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,Intraobserver and interobserver variability,"[71.0, 1280.0, 478.0, 1306.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,10,text,"The mean κ value for intraobserver variability was 0.86 (95% CI, 0.75 to 1.00) for bone marrow edema, 0.68 (95% CI, 0.60 to 0.795) for AC joint distension, and 0.85 (95% CI, 0.75 to 0.94) for impressi","[69.0, 1331.0, 559.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,"edema, 0.70 (95% CI, 0.65 to 0.75) for AC joint distension, +and 0.84 (95% CI, 0.82 to 0.94) for impression. The mean +intraobserver variability and interobserver variability of im- +pression and bone ma","[594.0, 985.0, 1085.0, 1179.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,Discussion,"[598.0, 1204.0, 713.0, 1231.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,13,text,The most important finding of our study was the correlation of 3 MRI signs with the clinical diagnosis of symptomatic AC osteoarthritis. The presence of bone marrow edema predicted a 100% probability ,"[594.0, 1259.0, 1086.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,ARTICLE IN PRESS,"[420.0, 10.0, 799.0, 50.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,Signs on MRI for AC osteoarthritis,"[105.0, 64.0, 387.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,number,5,"[1100.0, 66.0, 1114.0, 85.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,3,figure_title,Table I Demographic and clinical data and MRI findings of study population,"[115.0, 121.0, 699.0, 144.0]",figure_caption_candidate,0.85,"[""figure_title label: Table I Demographic and clinical data and MRI findings of st""]",figure_caption,0.85,,reference_like,citation_line,False,False +5,4,table,"
Group 1 (n = 70)Group 2 (n = 70)P value
Male sex32 (45.7%)34 (48.6%).735
Mean age (SD), yr
Group 1 (n = 70)Group 2 (n = 70)Odds ratio (95% CI)P value
Joint space ≤2 mm57 (81%)71 (87%)0.647 (0.257-,"[113.0, 659.0, 1101.0, 850.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,11,vision_footnote,"MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval.","[115.0, 855.0, 651.0, 876.0]",footnote,0.7,"[""vision_footnote label: MRI, magnetic resonance imaging; AC, acromioclavicular; CI, ""]",footnote,0.7,body_zone,body_like,none,True,True +5,12,vision_footnote,"Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chronic subacromial pain syndrome.","[115.0, 876.0, 871.0, 897.0]",footnote,0.7,"[""vision_footnote label: Group 1 patients had symptomatic AC osteoarthritis, and grou""]",footnote,0.7,body_zone,body_like,none,True,True +5,13,figure_title,Table III Multivariate logistic regression analysis of predictors on MRI for symptomatic AC osteoarthritis,"[114.0, 955.0, 908.0, 978.0]",figure_caption,0.85,"[""figure_title label: Table III Multivariate logistic regression analysis of predi""]",figure_caption,0.85,body_zone,table_caption_like,none,True,True +5,14,table,
VariableCoefficientOdds ratio (95% CI)P value
Inferior joint distension ≥3 mm1.2173.378 (1.249-9.133).016
Group 1 (n = 70)Group 2 (n = 70)P valu", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:5", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "MRI, magnetic resonance imaging; SD, standard deviation; AC, acromioclavicular.", + "found_in_fulltext": true, + "fulltext_offset": 16855 + }, + { + "block_id": "p5:6", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chr", + "found_in_fulltext": true, + "fulltext_offset": 16935 + }, + { + "block_id": "p5:7", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "* Data are missing for 3 patients.", + "found_in_fulltext": true, + "fulltext_offset": 17047 + }, + { + "block_id": "p5:8", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Data are missing for 1 patient.", + "found_in_fulltext": true, + "fulltext_offset": 17082 + }, + { + "block_id": "p5:9", + "page": 5, + "role": "figure_caption_candidate", + "zone": "body_zone", + "render_default": false, + "snippet": "Table II Univariate association between potential predictor variables on MRI and", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:10", + "page": 5, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
Group 1 (n = 70)Group 2 (n = 70)Odds r", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:11", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval.", + "found_in_fulltext": true, + "fulltext_offset": 17114 + }, + { + "block_id": "p5:12", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chr", + "found_in_fulltext": true, + "fulltext_offset": 16935 + }, + { + "block_id": "p5:14", + "page": 5, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
VariableCoefficientOdds ratio (95% CI)", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:15", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval.", + "found_in_fulltext": true, + "fulltext_offset": 17114 + }, + { + "block_id": "p5:16", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "findings, with good to excellent $ \\kappa $ values, are easy to use and can assi", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:17", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Several clinical tests are available to diagnose symptomatic AC osteoarthritis. ", + "found_in_fulltext": true, + "fulltext_offset": 17564 + }, + { + "block_id": "p5:18", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "varying accuracy.3,13,22 The current diagnostic process in shoul- der pathology ", + "found_in_fulltext": true, + "fulltext_offset": 18666 + }, + { + "block_id": "p5:19", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "There are limited data available in the literature about the association between", + "found_in_fulltext": true, + "fulltext_offset": 19212 + }, + { + "block_id": "p6:0", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "6", + "found_in_fulltext": true, + "fulltext_offset": 364 + }, + { + "block_id": "p6:1", + "page": 6, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "ARTICLE IN PRESS", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:2", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "E.J.D. 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This was also found ", + "found_in_fulltext": true, + "fulltext_offset": 19540 + }, + { + "block_id": "p6:4", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Another study showed the association of osteophytes and AC joint distension with", + "found_in_fulltext": true, + "fulltext_offset": 19802 + }, + { + "block_id": "p6:5", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The comparative study of Choo et al $ ^{2} $ found bone edema in only 9% of symp", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:6", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "One of the strengths of this study is the relatively large group of consecutive ", + "found_in_fulltext": true, + "fulltext_offset": 21670 + }, + { + "block_id": "p6:7", + "page": 6, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "This study also has some limitations. It has a retrospective design, creating a ", + "found_in_fulltext": true, + "fulltext_offset": 22001 + }, + { + "block_id": "p6:8", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "amination, and additional radio-diagnostic imaging studies. Painful palpation of", + "found_in_fulltext": true, + "fulltext_offset": 22911 + }, + { + "block_id": "p6:9", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The prediction of symptomatic AC osteoarthritis using impression on the supraspi", + "found_in_fulltext": true, + "fulltext_offset": 24625 + }, + { + "block_id": "p6:10", + "page": 6, + "role": "structured_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "Conclusion", + "found_in_fulltext": true, + "fulltext_offset": 1928 + }, + { + "block_id": "p6:11", + "page": 6, + "role": "structured_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "In this study we identified predictive MRI signs in patients with symptomatic AC", + "found_in_fulltext": true, + "fulltext_offset": 25249 + }, + { + "block_id": "p6:12", + "page": 6, + "role": "structured_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "Disclaimer", + "found_in_fulltext": true, + "fulltext_offset": 25636 + }, + { + "block_id": "p6:13", + "page": 6, + "role": "structured_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "The authors, their immediate families, and any research foundations with which t", + "found_in_fulltext": true, + "fulltext_offset": 25649 + }, + { + "block_id": "p6:14", + "page": 6, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": true, + "fulltext_offset": 25877 + }, + { + "block_id": "p6:15", + "page": 6, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. Brown JN, Roberts SN, Hayes MG, Sales AD. Shoulder pathology associated with ", + "found_in_fulltext": true, + "fulltext_offset": 25888 + }, + { + "block_id": "p6:16", + "page": 6, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "2. Choo HJ, Lee SJ, Kim JH, Cha SS, Park YM, Park JS, et al. Can symptomatic acr", + "found_in_fulltext": true, + "fulltext_offset": 26054 + }, + { + "block_id": "p6:17", + "page": 6, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "3. Chronopoulos E, Kim TK, Park HB, Ashenbrenner D, McFarland EG. 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"sha256:35bc057141e6d76c7f802e661437fb498b46279ecfc0c624c8b3b48797a65926", + "page_007.png": "sha256:575b6c8b47ee0b4b36d9b26b56db81560728ca3d196e2bf4a9f03c2c08f2647d", + "page_008.png": "sha256:e8c07a1a9cf4ee274ac5c9c621ccccafc4316f22df856d6f963e9e58eedd4a3d", + "page_009.png": "sha256:bac25523dc6ad67f2775e001ed9151112c714e1ceb4d26ff617fd435ed579d90", + "page_010.png": "sha256:36c94d2fb1c45272823d28bda274f2e23ac1996df861825203bb5a5ede6ac3d4", + "page_011.png": "sha256:b712e2094998432a68cf90109551c07b64d308622bea5eae2160cb8c8ff02040", + "page_012.png": "sha256:57602e13fd82852378ed69ff10dd76432c2d54abbe35ebfea3857c73d0151025", + "page_013.png": "sha256:ea2c5694243d61fc873a5db4cae4a444b14411ed2dfd5634b6e0643edcd95b84" + } + }, + "artifact_freshness": { + "missing": [], + "mismatches": [ + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" + ], + "annotated_pages_rendered": [ + "page_001.png", + "page_002.png", + "page_003.png", + "page_004.png", + "page_005.png", + "page_006.png", + "page_007.png", + "page_008.png", + "page_009.png", + "page_010.png", + "page_011.png", + "page_012.png", + "page_013.png" + ] + }, + "reviewed_pages": [ + 1, + 3, + 4, + 5, + 6, + 7, + 8, + 10 + ], + "reviewed_blocks": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p1:21", + "p1:22", + "p1:23", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:4", + "p3:5", + "p3:6", + "p3:7", + "p3:8", + "p3:9", + "p3:10", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p4:10", + "p4:11", + "p4:12", + "p4:13", + "p4:14", + "p4:15", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p5:11", + "p5:12", + "p5:13", + "p5:14", + "p6:0", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p6:5", + "p6:6", + "p6:7", + "p6:8", + "p6:9", + "p6:10", + "p6:11", + "p6:12", + "p7:0", + "p7:1", + "p7:2", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p7:12", + "p8:0", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p10:0", + "p10:1", + "p10:2", + "p10:3", + "p10:4", + "p10:5", + "p10:6", + "p10:7", + "p10:8", + "p10:9", + "p10:10", + "p10:11", + "p10:12", + "p10:13" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:6", + "p1:7", + "p1:10", + "p1:18", + "p1:20", + "p1:22", + "p2:1", + "p2:2", + "p2:5", + "p2:6", + "p2:8", + "p3:0", + "p3:2", + "p3:5", + "p3:6", + "p3:10" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/24YKLTHQ/audit_report.md b/audit/24YKLTHQ/audit_report.md new file mode 100644 index 00000000..d3773d43 --- /dev/null +++ b/audit/24YKLTHQ/audit_report.md @@ -0,0 +1,39 @@ +# OCR Truth Audit Report - 24YKLTHQ + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 4, 5, 6, 7, 8, 10] +- Reviewed blocks: 114 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/24YKLTHQ/audit_scope.json b/audit/24YKLTHQ/audit_scope.json new file mode 100644 index 00000000..12b49a3d --- /dev/null +++ b/audit/24YKLTHQ/audit_scope.json @@ -0,0 +1,930 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 3, + 4, + 5, + 6, + 7, + 8, + 10 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p1:21", + "p1:22", + "p1:23", + "p3:8", + "p4:3", + "p4:4", + "p4:6", + "p5:4", + "p5:10", + "p6:7", + "p6:8", + "p6:9", + "p6:10", + "p6:11", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p8:6", + "p10:3", + "p10:4", + "p10:5", + "p10:7", + "p10:8", + "p10:9", + "p10:10", + "p10:11", + "p10:12", + "p10:13" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + 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cho""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,9,text,El efecto de la frecuencia en la estimulación eléctrica de condrocitos,"[201.0, 413.0, 1047.0, 445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,10,text,"Juan Jairo Vaca-González $ ^{ID1} $, Juan Felipe Escobar-Huertas $ ^{ID2} $, Diego Alexander Garzón-Alvarado $ ^{ID3} $","[110.0, 459.0, 1130.0, 486.0]",authors,0.8,"[""page-1 zone author_zone: Juan Jairo Vaca-Gonz\u00e1lez $ ^{ID1} $, Juan Felipe Escobar-Hue""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,11,paragraph_title,INFORMACIÓN DEL ARTÍCULO,"[111.0, 507.0, 380.0, 531.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: INFORMACI\u00d3N DEL ART\u00cdCULO""]",section_heading,0.5,body_zone,heading_like,none,True,True +1,12,text,"Historia del artículo: +Enviado: 03/04/2020 +Recibido: 17/04/2020 +Aceptado: 28/05/2020","[111.0, 544.0, 293.0, 638.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,13,text,"Keywords: +Cartilage Explants +Chondrocytes +Computational model +Electric Fields +Frequency Dependence +Scaffolds","[110.0, 666.0, 288.0, 828.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords:\nCartilage Explants\nChondrocytes\nComputational mode""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,14,image,,"[114.0, 868.0, 270.0, 924.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,15,text,"Palabras clave: +Explantes de Cartílago +Condrocitos +Modelo Computacional +Campos Eléctricos +Dependencia de la Frecuencia +Andamios","[109.0, 964.0, 341.0, 1125.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,paragraph_title,ABSTRACT,"[442.0, 506.0, 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Some studies have evidenced the role of frequency","[439.0, 536.0, 1117.0, 916.0]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,18,paragraph_title,RESUMEN,"[442.0, 924.0, 534.0, 944.0]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: RESUMEN""]",authors,0.6,body_zone,heading_like,short_fragment,False,True +1,19,text,"La estimulación eléctrica es una terapia no invasiva utilizada para estimular la dinámica de los condrocitos: proliferación, migración, morfología y síntesis molecular. Algunos estudios han evidenciad","[438.0, 958.0, 1116.0, 1385.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,footnote," $ ^{1} $School of Health and Sports Sciences, Fundación Universitaria del Área Andina, Bogotá, Colombia. E-mail: jvaca8@areandina.edu.co","[137.0, 1385.0, 1086.0, 1406.0]",footnote,0.7,"[""footnote label: $ ^{1} $School of Health and Sports Sciences, Fundaci\u00f3n Univ""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,21,footnote,"²Research group in Design, Analysis and Development of Engineering Systems – GIDAD, Fundación Universitaria Los Libertadores, Bogotá, Colombia. E-mail: jfescobarh@libertadores.edu.co","[112.0, 1405.0, 1113.0, 1438.0]",footnote,0.7,"[""footnote label: \u00b2Research group in Design, Analysis and Development of Engin""]",footnote,0.7,body_zone,body_like,none,True,True +1,22,footnote," $ ^{3} $Modeling and Numerical Methods in Engineering Research Group (GNUM) and Biomimetics Laboratory, Biotechnology Institute, Universidad Nacional de Colombia, Bogotá, Colombia. E-mail: dagarzona@","[109.0, 1439.0, 1114.0, 1475.0]",footnote,0.7,"[""footnote label: $ ^{3} $Modeling and Numerical Methods in Engineering Resear""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,23,footnote,"Cité this article as: J. J. Vaca-González, J. F. Escobar-Huertas and D. A. Garzón-Alvarado, “The effect of frequency in the electrical stimulation of chondrocytes”, Vision electronica, vol. 14, no. 1,","[109.0, 1475.0, 1107.0, 1516.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Cit\u00e9 this article as: J. J. Vaca-Gonz\u00e1lez, J. F. Escobar-Hue""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,0,number,7,"[111.0, 100.0, 125.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,"J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO","[590.0, 95.0, 1115.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,2,paragraph_title,1. Introduction,"[108.0, 151.0, 285.0, 175.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,frontmatter_side_zone,heading_like,heading_numbered,True,True +2,3,text,"Hyaline cartilage is an avascular tissue composed by a single cell type, the chondrocyte [1]. This cell is responsible for synthesizing the main macromolecules located in the cartilaginous tissue: col","[106.0, 204.0, 607.0, 566.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Considering that hyaline cartilage responds to external biophysical stimuli, it has been demonstrated that tissue dynamics are modified when electric fields (EFs) are applied. For instance, in vitro a","[106.0, 589.0, 606.0, 1264.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"the charging time of the cell membrane; therefore, cells immersed in this kind of medium need to be stimulated with higher EFs to induce electroporation in the cell membrane [25]. In a study carried o","[106.0, 1262.0, 606.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"of the transmembrane potential on prolate and oblate +spheroidal cells stimulated with EFs. Results evidenced +that the transmembrane potential strongly depends on +the cell orientation when a cell is be","[614.0, 151.0, 1117.0, 441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"Even though the computational models evidenced that transmembrane potential vary according to cell shape, size and orientation, the models did not consider different frequencies and dielectric propert","[614.0, 470.0, 1118.0, 1428.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,footer,Universidad Distrital Francisco José de Caldas - Facultad tecnológica,"[594.0, 1477.0, 1115.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,header,THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES,"[108.0, 96.0, 640.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,8,"[1100.0, 100.0, 1113.0, 114.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,"to the ossification of the explant. The findings derived from this computational model could be used to estimate the EFs desired to trigger intracellular responses from the cell. In fact, it has been ","[106.0, 144.0, 606.0, 410.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,2. Materials and Methods,"[107.0, 437.0, 393.0, 461.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,4,paragraph_title,2.1. Geometrical models and boundary conditions,"[107.0, 480.0, 565.0, 505.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Geometrical models and boundary conditions""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,5,text,"A bi-dimensional axisymmetric domain was implemented to represent the capacitive coupled system. The capacitive coupled system is composed of two parallel stainless-steel electrodes, which are located","[106.0, 524.0, 607.0, 646.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"media and biological samples were placed within the +culture well plate, respectively (Figure 1). In this study, +biological samples were modelled using two different well +plate dimensions according to p","[614.0, 144.0, 1117.0, 624.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,figure_title,Figure 1: Geometries used for computational simulations. A) Culture well plate used for electrical stimulations. B) Three-dimensional representative scheme of the three culture systems simulated. C) R,"[106.0, 657.0, 1115.0, 730.0]",figure_caption,0.92,"[""figure_title label: Figure 1: Geometries used for computational simulations. 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The scaffold was simulated as a drop with a radius of 3.5 mm with c", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:3", + "page": 5, + "role": "body_paragraph", + "zone": "display_zone", + "render_default": true, + "snippet": "Figure 2: Meshes of the three different culture systems simulated in the study. ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:6", + "page": 5, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2.5. Model implementation", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:7", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The procedures to simulate the effect generated by EF's on a single cell, a cart", + "found_in_fulltext": true, + "fulltext_offset": 10794 + }, + { + "block_id": "p5:8", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "temperature and pressure, were assigned within the model. Once the domains were ", + "found_in_fulltext": true, + "fulltext_offset": 11407 + }, + { + "block_id": "p5:11", + "page": 5, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "3. Results", + "found_in_fulltext": true, + "fulltext_offset": 12336 + }, + { + "block_id": "p5:12", + "page": 5, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "3.1. EFs distribution in monolayer cultures", + "found_in_fulltext": true, + "fulltext_offset": 12351 + }, + { + "block_id": "p5:13", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The flow of the EFs through the monolayer cell culture system is completely homo", + "found_in_fulltext": true, + "fulltext_offset": 12395 + }, + { + "block_id": "p5:14", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 •", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:0", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "11", + "found_in_fulltext": true, + "fulltext_offset": 13672 + }, + { + "block_id": "p6:1", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:2", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "the culture media (Figure 4B). Regarding the EFs in the cytoplasm of the chondro", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:3", + "page": 6, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "3.2. EFs distribution in cartilage explants", + "found_in_fulltext": true, + "fulltext_offset": 12968 + }, + { + "block_id": "p6:4", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A heterogeneous EF distribution was observed inside the explant (Figure 5A). Res", + "found_in_fulltext": true, + "fulltext_offset": 13012 + }, + { + "block_id": "p6:5", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "were evidenced at the base of the bone. The EFs in the middle of the bone were 3", + "found_in_fulltext": true, + "fulltext_offset": 13571 + }, + { + "block_id": "p6:11", + "page": 6, + "role": "figure_caption_candidate", + "zone": "body_zone", + "render_default": false, + "snippet": "Source: own", + "found_in_fulltext": true, + "fulltext_offset": 14762 + }, + { + "block_id": "p6:12", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Universidad Distrital Francisco José de Caldas - Facultad tecnológica", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:0", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:1", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "12", + "found_in_fulltext": true, + "fulltext_offset": 15104 + }, + { + "block_id": "p7:11", + "page": 7, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Source: own", + "found_in_fulltext": true, + "fulltext_offset": 14762 + }, + { + "block_id": "p7:12", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 •", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:0", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "13", + "found_in_fulltext": true, + "fulltext_offset": 9225 + }, + { + "block_id": "p8:1", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. 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Th", + "found_in_fulltext": true, + "fulltext_offset": 15350 + }, + { + "block_id": "p8:7", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Universidad Distrital Francisco José de Caldas - Facultad tecnológica", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:0", + "page": 9, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:1", + "page": 9, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "14", + "found_in_fulltext": true, + "fulltext_offset": 265 + }, + { + "block_id": "p9:2", + "page": 9, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "4. Discussion", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:3", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This study presents a computational model that evidences the effects generated b", + "found_in_fulltext": true, + "fulltext_offset": 16589 + }, + { + "block_id": "p9:4", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Considering the cell membrane as a capacitor, the EF's in this computational mod", + "found_in_fulltext": true, + "fulltext_offset": 18681 + }, + { + "block_id": "p9:5", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Even though the activation of ionic channels of chondrocytes was not modelled, t", + "found_in_fulltext": true, + "fulltext_offset": 19317 + }, + { + "block_id": "p9:6", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Depending on the EFs applied and the stimulation time, the in vitro procedures o", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:7", + "page": 9, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 •", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:0", + "page": 10, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "15", + "found_in_fulltext": true, + "fulltext_offset": 24248 + }, + { + "block_id": "p10:1", + "page": 10, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. 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the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:21" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:22" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:23" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:24" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:25" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:26" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:27" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:28" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:29" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:30" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:31" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:32" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:33" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:34" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p11:35" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:4", + "p1:12", + "p1:14", + "p1:15", + "p2:1", + "p2:2", + "p2:3", + "p2:9", + "p2:13", + "p3:0", + "p3:2", + "p3:10", + "p3:11", + "p4:1", + "p4:2", + "p4:5", + "p4:6", + "p5:0", + "p5:2" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/27MSS3VH/audit_report.md b/audit/27MSS3VH/audit_report.md new file mode 100644 index 00000000..0ae077ee --- /dev/null +++ b/audit/27MSS3VH/audit_report.md @@ -0,0 +1,37 @@ +# OCR Truth Audit Report - 27MSS3VH + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 4, 5, 6, 8, 10, 11] +- Reviewed blocks: 118 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/27MSS3VH/audit_scope.json b/audit/27MSS3VH/audit_scope.json new file mode 100644 index 00000000..ea65ab24 --- /dev/null +++ b/audit/27MSS3VH/audit_scope.json @@ -0,0 +1,748 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 3, + 4, + 5, + 6, + 8, + 10, + 11 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p3:3", + "p4:3", + "p5:3", + "p6:6", + "p8:2", + "p10:1", + "p10:9", + "p11:17", + "p11:18", + "p11:19", + "p11:20", + "p11:21", + "p11:22", + "p11:23", + "p11:24", + "p11:25", + "p11:26", + "p11:27", + "p11:28", + "p11:29", + "p11:30", + "p11:31", + "p11:32", + "p11:33", + "p11:34", + "p11:35" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:9", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:10", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:11", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:12", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:13", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:14", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:15", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:16", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:3", + "page": 3, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:3", + "page": 4, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p5:3", + "page": 5, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p6:6", + "page": 6, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p8:2", + "page": 8, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p10:1", + "page": 10, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p10:9", + "page": 10, + "required_reason": [ + "same_page_boundary" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p11:17", + "page": 11, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p11:18", + "page": 11, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + 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Mol. Diagn. 13(6), 553–566 (2013)","[375.0, 633.0, 726.0, 657.0]",structured_insert_candidate,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False +1,5,text,"Vítor E Santo $ ^{1,2} $, Márcia T Rodrigues $ ^{1,2} $ and Manuela E Gomes $ ^{*1,2} $","[115.0, 692.0, 353.0, 771.0]",frontmatter_noise,0.7,"[""keyword-like block: V\u00edtor E Santo $ ^{1,2} $, M\u00e1rcia T Rodrigues $ ^{1,2} $ and ""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,6,text,"³B's Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806–909 Caldas das Taipas, Guimarães, Portugal +²ICV","[115.0, 780.0, 352.0, 962.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00b3B's Research Group \u2013 Biomaterials, Biodegradables and Biomi""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,7,abstract,"The current limitations of regenerative medicine strategies may be overcome through the use of magnetic nanoparticles (MNPs), a class of nanomaterial typically composed of magnetic elements that can b","[373.0, 691.0, 1144.0, 971.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,8,text,KEYWORDS: magnetic particles • magnetic responsive systems • regenerative medicine • stem cells • theranostics • tissue engineering,"[379.0, 987.0, 1121.0, 1028.0]",frontmatter_noise,0.7,"[""frontmatter noise text: KEYWORDS: magnetic particles \u2022 magnetic responsive systems \u2022""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,9,text,The goal of producing functional tissue substitutes using tissue engineering or other regenerative medicine strategies is challenged by the complexity of organ architectures $ [1] $. Some of the most,"[374.0, 1040.0, 753.0, 1449.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,10,text,Nanoparticle research within regenerative medicine has been mainly focused on the development of delivery systems for biomolecules and reinforcing phase for polymeric matrices in 3D scaffolds for tiss,"[375.0, 1449.0, 753.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,text,"development of delivery systems for biomol- +ecules and reinforcing phase for polymeric +matrices in 3D scaffolds for tissue engineering +[4]. 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Metallic nanoparticle contrast agents are typically applied for in vivo imaging","[67.0, 176.0, 576.0, 297.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,Magnetic nanoparticles (MNPs) have shown high potential for different biomedical applications as they present the ability to be manipulated under the influence of an external magnetic field [7]. The m,"[67.0, 297.0, 576.0, 656.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,The ability of MNPs to be functionalized and concurrently respond to a magnetic field has made them a useful tool for theranostics [7]. 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Alte","[588.0, 248.0, 1099.0, 612.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,3D magnetic constructs as the basis for a new generation of tissue-engineered substitutes,"[590.0, 632.0, 1012.0, 679.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3D magnetic constructs as the basis for a new generation of ""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,True,True +2,9,text,"It is well known that the mechanical environment to which native tissues and cells are exposed significantly influences the homeostasis and regeneration processes. 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Potential strategies that can be used to augment t""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,5,text,late the delivery of bioactive agents with an external stimulus can potentially improve the safety and efficiency of these agents $ [34–36] $. Table 1 summarizes some of the scaffolds/hydrogels incor,"[114.0, 850.0, 621.0, 944.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"Zhao et al. introduced the designation of active scaffolds, which can offer the possibility of controlling the properties of the construct through an external stimulus as opposite to traditional porou","[113.0, 945.0, 622.0, 1185.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,Bock et al. proposed a promising new strategy based on the development of new magnetic scaffolds that could act as fixed ‘stations’ to attract growth factors and stem cells bound to MNPs [37]. This ap,"[112.0, 1186.0, 622.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"of tumors [38,39]; however, the provided spatial accuracy and ther- +apeutic efficacy is also of major interest for tissue engineering +applications. The incorporation of SPMNs instead of the common +MNP","[634.0, 847.0, 1145.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,The use of magnetic forces can also be directed towards the improvement of the efficiency of cell seeding. This step is a critical parameter on tissue engineering strategies as the success of the cons,"[635.0, 1377.0, 1146.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,footer,www.expert-reviews.com,"[115.0, 1534.0, 327.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,11,number,555,"[1103.0, 1529.0, 1142.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Review,"[88.0, 95.0, 182.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,"Santo, Rodrigues & Gomes","[206.0, 99.0, 459.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,figure_title,Table 1. Compilation of studies reporting the use of magnetic stimulation for the development of 3D constructs for tissue engineering and regenerative medicine.,"[74.0, 185.0, 1037.0, 237.0]",table_caption,0.9,"[""table prefix matched: Table 1. Compilation of studies reporting the use of magneti""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,3,table,"
Frequency (kHz)Reference
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constructs for tissue engineering and regenerative medicine.
Construct fabrication strategiesApproachMagnetic roleExperimental se","[74.0, 203.0, 1090.0, 1409.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,4,vision_footnote,AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona,"[74.0, 1398.0, 1038.0, 1451.0]",footnote,0.7,"[""vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star""]",footnote,0.7,body_zone,body_like,none,True,True +4,5,number,556,"[71.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,6,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1533.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403.0, 99.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header,Review,"[1031.0, 93.0, 1128.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,figure_title,Table 1. Compilation of studies reporting the use of magnetic stimulation for the development of 3D constructs for tissue engineering and regenerative medicine (cont.).,"[120.0, 183.0, 1080.0, 234.0]",table_caption,0.9,"[""table prefix matched: Table 1. Compilation of studies reporting the use of magneti""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,3,table,"
Construct fabrication strategiesApproachMagnetic roleExperimental set upApplicationRef.
Dispersion/impregnation","[117.0, 191.0, 1137.0, 1122.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,4,vision_footnote,AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona,"[118.0, 1129.0, 1082.0, 1181.0]",footnote,0.7,"[""vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star""]",footnote,0.7,body_zone,body_like,none,True,True +5,5,text,"of the scaffolds and insufficient migration of the cells into the scaffolds lead to a shortage of initially seeded cells, resulting in less significant outcomes. In this context, the functionalization","[112.0, 1208.0, 623.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,"the formulations in which the magnetic force was applied, thus +demonstrating the potential of this novel design for tissue engi- +neering purposes. Depending on the scaffold, an improvement on +cell see","[634.0, 1207.0, 1145.0, 1424.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,Other methods in which the application of magnetic fields can be useful are the bottom-up scaffold fabrication techniques. The assembly of building blocks such as cell-encapsulating microscale,"[635.0, 1424.0, 1145.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,footer,www.expert-reviews.com,"[115.0, 1534.0, 328.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,9,number,557,"[1103.0, 1528.0, 1141.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Review,"[87.0, 94.0, 183.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,"Santo, Rodrigues & Gomes","[206.0, 98.0, 458.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,2,text,"hydrogels mimics the structure of native tissues, typically composed by repeating functional units [43]. Despite the promising opportunities provided by this approach, the control over this assembly i","[67.0, 177.0, 577.0, 848.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,3,text,A recent report by Tasoglu et al. has shown that the magnetic assembly can be provided in the absence of MNPs [43]. The results demonstrate that PEG hydrogels that were exposed to UV radiation for lon,"[69.0, 849.0, 577.0, 898.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,text,"demonstrate that PEG hydrogels that were exposed to UV radia- +tion for longer periods traveled towards the magnets with higher +velocity. The exposure to UV induces the formation of free radi- +cals, wh","[588.0, 176.0, 1101.0, 849.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,text,"The fabrication of magnetically responsive hydrogels crosslinked with paramagnetic ions has also been pursued [48]. Typically, a","[589.0, 848.0, 1099.0, 899.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,image,,"[77.0, 925.0, 1086.0, 1362.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +6,7,figure_title,"Figure 2. Sequential magnetic fusion for the formation of a cartilage construct. (A) Sixteen spheroid aggregates were formed through the use of a network of magnetic tips, which were then placed in co","[80.0, 1386.0, 1080.0, 1489.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Sequential magnetic fusion for the formation of a ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,8,number,558,"[71.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,9,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1533.0, 1095.0, 1552.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[402.0, 99.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header,Review,"[1031.0, 93.0, 1128.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,"correlation between the concentration of the paramagnetic ions and magnetic field gradient can be achieved. In an externally applied magnetic field, the paramagnetic hydrogel spheres assemble into ord","[111.0, 176.0, 622.0, 345.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,Another promising tissue engineering methodology where a 3D tissue is constructed without artificial scaffolds is the magnetically induced cell sheet technology (TABLE 1). MNPs can label specific cell,"[112.0, 344.0, 622.0, 1018.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"The use of external magnetic fields present some limitations, namely the targeting challenge of deep tissues as the targeting efficiency depends on the distance between the magnet and the tissue of in","[112.0, 1017.0, 623.0, 1400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"effect of labeling stem cells with MNPs. They induce mechani- +cal stimulation through different mechanisms, namely magnetic +twisting, mechanosensitive ion channel activation, targeted ion +channel acti","[633.0, 176.0, 1145.0, 320.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Furthermore, the mechanical stimulation induced by magnetic forces has also been shown to produce significant effects on cells, increasing their metabolic activity during the stimulation period [55]. ","[113.0, 1401.0, 623.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"pi p y +general, no adverse effects are found. +Wu et al. demonstrated an enhancement of mitochondrial +activity and expression of bone-related genes in human bone +marrow MSCs adhered to iron-containing ","[633.0, 320.0, 1145.0, 825.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"The feasibility of mechanical stimulation induced by magnetic forces has been shown to promote osteogenic and chondrogenic differentiation of MSCs [28,29] and to promote the organization of endothelia","[634.0, 824.0, 1144.0, 997.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,paragraph_title,Imaging & biosensing functionalities in tissue-engineered substitutes,"[635.0, 1015.0, 1062.0, 1064.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Imaging & biosensing functionalities in tissue-engineered su""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,10,text,"Major achievements in tissue engineering and regenerative medicine therapies are expected from a major challenge in nanomedicine, which consists of integrating selective targeting, imaging and directe","[633.0, 1065.0, 1145.0, 1500.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,footer,www.expert-reviews.com,"[114.0, 1534.0, 328.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,12,number,559,"[1103.0, 1529.0, 1142.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Review,"[88.0, 94.0, 182.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,"Santo, Rodrigues & Gomes","[207.0, 98.0, 458.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,2,image,,"[80.0, 184.0, 552.0, 1049.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +8,3,figure_title,"Figure 3. Endothelial cell organization in magnetic nanoparticle–alginate and alginate constructs. After the seeding into the MNP or alginate scaffold, the endothelial cells were exposed to an alterna","[79.0, 1076.0, 568.0, 1337.0]",figure_caption,0.92,"[""figure_title label: Figure 3. Endothelial cell organization in magnetic nanopart""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,4,text,"to lesion tissue [60], optical detectability and therapeutic delivery, as mentioned before.","[69.0, 1353.0, 574.0, 1400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"The application of MNPs in MRI-based technologies is envisioned to improve spatial resolution and soft tissue contrast at a nanoscale level, while simultaneously imaging tissue anatomy, physiology and","[68.0, 1401.0, 577.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"biomaterial systems. The detectability of MRI can be signifi- +cantly improved by the preferential accumulation of MNP contrast +agents if the targeting ligands, such as a protein or an antibody, are +at","[589.0, 175.0, 1099.0, 585.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,text,"SPMNs were described to be preferred to gadolinium chelates for cell labeling because they provide high signal contrasts in T2/T2*-weighted image sequences, are nontoxic and biodegradable [61].","[589.0, 585.0, 1098.0, 680.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"In the particular field of tissue engineering, MNPs hold great promise as a detection method for cell selection, cell sorting, spatial control of target cells and cell aggregation and adherence proper","[589.0, 681.0, 1099.0, 849.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,text,"Tracking of implanted cells in regenerative medicine strategies is critical to evaluate cell migration and cellular functions, and to help guide treatment for maximized therapeutic effect [62]. Magnet","[590.0, 849.0, 1098.0, 1185.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,text,The work of Bulte et al. was pioneer on the development of magnetodendrimers for labeling of stem and progenitor cells through a nonspecific membrane adsorption process with a subsequent intracellular,"[590.0, 1185.0, 1098.0, 1352.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,11,text,"The group of Chien Ho has also explored the possibility of using MRI to noninvasively monitor individual immune cells, primarily macrophages in vivo, after heart and lung transplantation $ [65] $. Th","[589.0, 1353.0, 1099.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,number,560,"[72.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,13,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1532.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403.0, 99.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,Review,"[1031.0, 94.0, 1128.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,2,text,"to complement biopsy is highly desirable. This technique may also be applied to assess the inflammatory response to implanted constructs in tissue engineering strategies, allowing the in situ monitori","[112.0, 177.0, 622.0, 272.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"Several protocols have already been described for in vivo tracking of human skeletal muscle cells [66]. Other protocols use cells as a circulating vehicle; for instance, erythrocytes have been explore","[112.0, 273.0, 622.0, 631.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"Other studies on MSC tracking in limb ischemia revealed MNPs' low toxicity and MSC detection after transplantation $ [68] $. In a rabbit osteochondral model, alginate-incorporated MNPs guided by exte","[113.0, 632.0, 622.0, 849.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,text,"Some pioneer studies on the design techniques of these multimodal nanoparticles have already been published. Zhu et al. developed probes combining magnetic, fluorescence and thermoresponsive features ","[112.0, 848.0, 623.0, 1211.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,paragraph_title,Biosensing,"[115.0, 1233.0, 216.0, 1255.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Biosensing""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +9,7,text,"The rapid and sensitive detection of molecular targets such as genetic material, proteins, enzymes, cytokines, growth factors, pathogens and metabolic byproducts secreted by cells is a major point in ","[112.0, 1256.0, 622.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,text,The detection and measurement of biomolecules in the culture medium where cell-laden tissue engineering systems are cultured gathers relevant information on in vitro cell behavior and thus of the tiss,"[113.0, 1377.0, 623.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,text,"methodologies. MNPs are also envisioned to play a role in the +detection, labeling and selective elimination of pathogens poten- +tially present in a culture medium or targeted antibacterial ther- +apy t","[634.0, 176.0, 1144.0, 369.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,10,text,"By incorporating advanced features, the detectability and applicability of MNPs have been dramatically expanded. Nevertheless, the location, distribution and long-term viability of tagged cells for cl","[634.0, 368.0, 1145.0, 512.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,11,text,Preclinical assays for cardiac applications are already being performed. Subcutaneous sensors were implanted in rodents for noninvasive measuring cardiac-specific biomarker levels in an attempt to pre,"[633.0, 513.0, 1145.0, 682.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,12,paragraph_title,Remote-controlled therapies,"[636.0, 705.0, 893.0, 726.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Remote-controlled therapies""]",subsection_heading,0.6,body_zone,body_like,none,True,True +9,13,text,"Magnetic field therapies, often referred as pulsed electromagnetic field (PEMF) therapies, are already applied in clinical practice to promote bone healing in delayed unions and nonunions $ [71] $ wi","[634.0, 729.0, 1144.0, 920.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,14,text,"Pilot clinical trials also indicate the beneficial effects of PEMF on pain relief $ [73,75,76] $, in particular the rapid impact on pain reduction from early knee osteoarthritis $ [75] $ or osteonec","[634.0, 920.0, 1144.0, 1064.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,15,text,One of the reported effects of this therapy includes the enhancement of metabolic activity of chondrocytes [77–79] and the prevention of the catabolic effects of inflammation [80–84] caused by osteoar,"[634.0, 1065.0, 1145.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,16,footer,www.expert-reviews.com,"[115.0, 1534.0, 328.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,17,number,561,"[1103.0, 1529.0, 1140.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,"Review Santo, Rodrigues & Gomes","[86.0, 96.0, 458.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,image,,"[78.0, 186.0, 1090.0, 421.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,2,figure_title,Figure 4. Magnet-scaffold configurations suggested by Russo et al. (A) External permanent magnetic ring (EM); (B) implanted permanent magnetic pins (PM); (C) implanted stainless steel pins in the fiel,"[79.0, 439.0, 1065.0, 561.0]",figure_caption,0.92,"[""figure_title label: Figure 4. Magnet-scaffold configurations suggested by Russo ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +10,3,text,"growth factors, including bone morphogenetic proteins and TGF $ [87,88] $. Angiogenesis $ [89,90] $ and mechanical properties $ [91] $ were also reported to be enhanced post-therapy.","[67.0, 584.0, 576.0, 656.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,"Despite the fact that remote-controlled therapies are poorly explored in the fields of cell and tissue engineering, increasing focus has been devoted to explore the remote control applications, includ","[68.0, 657.0, 576.0, 1233.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"PEMF therapies have been already US FDA approved for several pathologies including nonunion bone fractures and arthritic pain, but studies directed to tissue engineering and regenerative medicine stra","[67.0, 1233.0, 577.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"would stimulate implantable scaffolds. The incorporation of +MNPs in the scaffolds in combination with PEMF stimulation +would likely result in a synergistic therapeutic effect. In the case +of multifunc","[588.0, 583.0, 1099.0, 945.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,text,"Selective control of cell function by applying time-varying magnetic fields has added a new, exciting dimension to biology and medicine. The ability to remotely control cell or construct fate locally ","[588.0, 944.0, 1099.0, 1138.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,paragraph_title,Expert commentary,"[591.0, 1161.0, 779.0, 1183.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Expert commentary""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,9,text,"Besides sorting and isolation abilities, MNPs may also be used as pulsatile delivery systems for the release of selected growth factors. Magnetism is acknowledged as an advantageous physical stimulus ","[588.0, 1185.0, 1100.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,number,562,"[72.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,11,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1532.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403.0, 99.0, 1006.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header,Review,"[1032.0, 94.0, 1127.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,2,text,Probably the most challenging and innovative aspects of magnetic-based approaches consist of the integration of the theranostic tools provided by the MNPs into a 3D tissue-engineered construct as well,"[114.0, 177.0, 621.0, 323.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,3,paragraph_title,Five-year view,"[115.0, 345.0, 253.0, 367.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Five-year view""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,4,text,"The increased number of literature reports shows a clear tendency for a significant increase in research focusing on magnetic responsive systems and their potential in the regenerative medicine field,","[113.0, 368.0, 621.0, 464.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"To fabricate 3D magnetic responsive tissue-engineered constructs with precisely controlled architectures, the ability to assemble cell-laden microscale magnetic hydrogels (M-gels) should be further ex","[114.0, 465.0, 621.0, 607.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,Research in this field is also expected to further explore the ability of magnetic systems to promote the release of relevant molecules through a magnetic switch on/off and their role on stem cell dev,"[115.0, 609.0, 622.0, 658.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"molecules through a magnetic switch on/off and their role on stem +cell development as well as the ability for the ex vivo stimulation +of implanted devices.","[636.0, 177.0, 1143.0, 247.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,8,text,"Finally, a great deal of attention is also expected to be directed to the clarification of the long-term fate of embedded MNPs before considering the clinical application of magnetic tissue-engineered","[636.0, 249.0, 1144.0, 343.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"In summary, in upcoming years, several advances are expected that will revolutionize the field as they hold the potential to overcome main obstacles to the routine use of tissue engineering therapies ","[636.0, 345.0, 1144.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,paragraph_title,Financial & competing interests disclosure,"[636.0, 465.0, 986.0, 487.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Financial & competing interests disclosure""]",subsection_heading,0.6,body_zone,body_like,none,True,True +11,11,text,The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in ,"[636.0, 491.0, 1145.0, 632.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,12,text,No writing assistance was utilized in the production of this manuscript.,"[653.0, 634.0, 1141.0, 657.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,13,paragraph_title,Key issues,"[121.0, 695.0, 225.0, 720.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Key issues""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,14,text,• Magnetic nanoparticles (MNPs) allow the development of magnetic responsive tissue-engineered systems that may enable pulsatile delivery of growth factors while simultaneously allowing magnetic stimu,"[120.0, 730.0, 1107.0, 794.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,15,text,• Magnetic responsive tissue-engineered systems may be obtained by direct incorporation of the MNPs into a 3D scaffold or hydrogel or by association of MNPs with stem cells that are subsequently seede,"[122.0, 797.0, 1129.0, 840.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,16,text,"• Magnetic responsive systems may allow simultaneous diagnostic and therapeutic functionalities; therapeutic functionalities include the possibility to enhance stem cells response, tailoring their loc","[120.0, 843.0, 1134.0, 993.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,17,paragraph_title,References,"[116.0, 1041.0, 220.0, 1062.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +11,18,reference_content,"Papers of special note have been highlighted as: +• of interest","[116.0, 1065.0, 422.0, 1106.0]",reference_item,0.85,"[""reference content label: Papers of special note have been highlighted as:\n\u2022 of intere""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +11,19,reference_content,•• of considerable interest,"[117.0, 1105.0, 286.0, 1124.0]",reference_item,0.85,"[""reference content label: \u2022\u2022 of considerable interest""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +11,20,reference_content,"1 Santo VE, Gomes ME, Mano JF, Reis RL. 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"annotated_pages/page_030.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p30:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_030.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p30:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_030.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_028.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_029.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_030.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_031.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_032.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_033.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_034.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_035.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:9", + "p1:10", + "p1:11", + "p2:0", + "p2:1", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:10", + "p3:0", + "p3:2", + "p3:5", + "p3:6", + "p3:7" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/28ALPCY7/audit_report.md b/audit/28ALPCY7/audit_report.md new file mode 100644 index 00000000..77921b57 --- /dev/null +++ b/audit/28ALPCY7/audit_report.md @@ -0,0 +1,46 @@ +# OCR Truth Audit Report - 28ALPCY7 + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 9, 12, 13, 15, 16, 17, 19, 22, 23, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36] +- Reviewed blocks: 240 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/28ALPCY7/audit_scope.json b/audit/28ALPCY7/audit_scope.json new file mode 100644 index 00000000..f43494fd --- /dev/null +++ b/audit/28ALPCY7/audit_scope.json @@ -0,0 +1,2176 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 9, + 12, + 13, + 15, + 16, + 17, + 19, + 22, + 23, + 25, + 26, + 27, + 28, + 29, + 30, + 31, + 32, + 33, + 34, + 35, + 36 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p9:6", + "p12:4", + "p12:5", + "p12:6", + "p12:7", + "p13:4", + "p13:5", + "p13:6", + "p13:7", + "p13:8", + "p13:9", + "p15:3", + "p16:3", + "p17:3", + "p17:4", + "p17:5", + "p17:6", + "p17:7", + "p17:9", + "p17:10", + "p19:5", + "p19:6", + "p19:7", + "p19:9", + "p22:3", + "p23:4", + "p25:1", + "p25:2", + "p25:3", + "p25:4", + "p25:5", + "p25:6", + "p25:7", + "p26:1", + "p26:2", + "p26:3", + "p26:4", + "p26:5", + "p27:1", + "p27:2", + "p27:3", + "p27:4", + "p27:5", + "p27:6", + "p28:0", + "p28:6", + "p28:7", + "p28:8", + "p29:0", + "p29:4", + "p29:5", + "p29:6", + "p29:7", + "p29:8", + "p29:9", + "p29:10", + "p29:11", + "p30:0", + "p30:4", + "p30:5", + "p30:6", + "p30:7", + "p30:8", + "p31:0", + "p31:4", + "p31:5", + "p31:6", + "p31:7", + "p31:8", + "p31:9", + "p32:0", + "p32:4", + "p32:5", + "p32:6", + "p32:7", + "p32:8", + "p32:9", + "p33:0", + "p33:4", + "p33:5", + "p33:6", + "p33:7", + "p33:8", + "p33:9", + "p33:10", + "p33:11", + "p34:0", + "p34:4", + "p34:5", + "p34:6", + "p34:7", + "p34:8", + "p34:9", + "p34:10", + "p35:0", + "p35:4", + "p35:5", + "p35:6", + "p35:7", + "p36:0", + "p36:3", + "p36:4", + "p36:5", + "p36:6", + "p36:9", + "p36:10", + "p36:12", + "p36:14", + "p36:16" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:9", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:10", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:11", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p2:3", + "page": 2, + "required_reason": [ + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p2:4", + "page": 2, + "required_reason": [ + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p2:5", + "page": 2, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p2:6", + "page": 2, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + 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"truth_reference_membership" + ] + }, + { + "block_id": "p12:6", + "page": 12, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p12:7", + "page": 12, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p13:4", + "page": 13, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p13:5", + "page": 13, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p13:6", + "page": 13, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p13:7", + "page": 13, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p13:8", + "page": 13, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p13:9", + "page": 13, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:3", + "page": 15, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p16:3", + "page": 16, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p17:3", + "page": 17, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p17:4", + "page": 17, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p17:5", + "page": 17, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p17:6", + "page": 17, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p17:7", + "page": 17, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p17:9", + "page": 17, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p17:10", + "page": 17, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p19:5", + "page": 19, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p19:6", + "page": 19, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p19:7", + "page": 19, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p19:9", + "page": 19, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p22:3", + "page": 22, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + 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Sci. Eng., Just Accepted Manuscript • DOI: 10.1021/acsbiomaterials.9b00858 • Publication Date (Web): 03 Sep 2019","[308.0, 369.0, 874.0, 414.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: ACS Biomater. Sci. Eng., Just Accepted Manuscript \u2022 DOI: 10.""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,7,text,"Downloaded from pubs.acs.org on September 3, 2019","[361.0, 420.0, 831.0, 445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,8,paragraph_title,Just Accepted,"[124.0, 515.0, 281.0, 541.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Just Accepted""]",frontmatter_noise,0.8,frontmatter_main_zone,heading_like,short_fragment,False,False +1,9,abstract,"“Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemic","[132.0, 564.0, 1058.0, 883.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,False,True +1,10,footer,"is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036","[591.0, 1562.0, 1071.0, 1595.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,11,footer,"Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth","[590.0, 1597.0, 1113.0, 1665.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[8.0, 90.0, 44.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,1,number,Page 1 of 36,"[12.0, 18.0, 122.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,doc_title,3D-printed $ \beta $-tricalcium phosphate scaffold combined with a pulse electromagnetic field promotes the repair of skull defects in rats,"[191.0, 182.0, 1000.0, 344.0]",unknown_structural,0.8,"[""page-1 zone title_zone: 3D-printed $ \\beta $-tricalcium phosphate scaffold combined""]",paper_title,0.8,body_zone,body_like,none,False,True +2,4,text,"Haifeng Liang $ ^{a} $, Xiao Liu $ ^{b} $, Ying Pi $ ^{a} $, Qiang Yu $ ^{a} $, Yukun Yin $ ^{a} $, Xian Li $ ^{a} $, Yipei Yang $ ^{a} $, Jing Tian $ ^{*a} $","[174.0, 380.0, 946.0, 408.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Haifeng Liang $ ^{a} $, Xiao Liu $ ^{b} $, Ying Pi $ ^{a} $,""]",authors,0.8,body_zone,body_like,none,False,True +2,5,text,"a Department of Orthopedics, Zhujiang Hospital, Southern Medical University, No. 253 Industrial Avenue, Haizhu, Guangzhou 510280, People's Republic of China","[174.0, 443.0, 1015.0, 533.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: a Department of Orthopedics, Zhujiang Hospital, Southern Med""]",affiliation,0.8,body_zone,body_like,none,True,True +2,6,text," $ ^{b} $ School of Materials Science and Engineering, South China University of Technology, Wushan, +Guangzhou 510640, People's Republic of China","[173.0, 568.0, 1015.0, 657.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{b} $ School of Materials Science and Engineering, South ""]",affiliation,0.8,body_zone,body_like,affiliation_marker,True,True +2,7,text,"*Corresponding author: Jing Tian, Email: tianjing_ortho@163.com","[176.0, 693.0, 748.0, 720.0]",frontmatter_support,0.78,"[""first-surviving-page support text: *Corresponding author: Jing Tian, Email: tianjing_ortho@163.""]",frontmatter_support,0.78,frontmatter_side_zone,support_like,none,True,True +2,8,paragraph_title,ABSTRACT,"[175.0, 815.0, 277.0, 842.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_side_zone,heading_like,short_fragment,True,True +2,9,abstract,"Trauma, infection, cancer and congenital diseases can lead to bone defects. The combination of 3D printing with biomaterials is of great significance in the treatment of bone defects. In addition, pul","[174.0, 880.0, 1017.0, 1533.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +2,10,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 85.0, 42.0, 1532.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +3,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,number,Page 2 of 36,"[1069.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,3,text,"proliferation and differentiation of rADSCs and the repair of a critical defect in the rat skull. +Therefore, the combination of $ \beta $-TCP and PEMF with 3D printing technology can provide better +t","[175.0, 164.0, 1015.0, 316.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,KEYWORDS: 3D printing; $ \beta $-tricalcium phosphate; pulse electromagnetic field; bone defect,"[175.0, 476.0, 953.0, 502.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +3,5,paragraph_title,INTRODUCTION,"[176.0, 664.0, 311.0, 687.0]",section_heading,0.9,"[""explicit scholarly heading: INTRODUCTION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,6,text,Pulse electromagnetic fields (PEMFs) are transient electromagnetic fields produced in a coil when a pulse current generated by a pulse generator passes through the coil. The strength and frequency of ,"[173.0, 726.0, 1017.0, 1503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 90.0, 44.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +4,1,number,Page 3 of 36,"[12.0, 18.0, 121.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 46.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,3,text,"PEMFs have a ""window effect"" $ ^{39} $; that is, the field strength, frequency and action time of PEMFs do not have linear relationships with the biological effects observed in cells. The field streng","[171.0, 162.0, 1019.0, 1504.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 84.0, 42.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +5,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,number,Page 4 of 36,"[1069.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,3,text,"nonunion and other orthopedic diseases, it is rarely used to treat bone defects. Prior to this study, we demonstrated that PEMF therapy (50 Hz, 1 mT) can promote the proliferation and osteogenic diffe","[174.0, 166.0, 1017.0, 441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"The treatment of bone defects has always been a clinical problem, and the gold standard for treatment is autografts. However, bone transplantation has disadvantages such as few available sources, a la","[173.0, 476.0, 1017.0, 1504.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10.0, 90.0, 42.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +6,1,number,Page 5 of 36,"[13.0, 18.0, 121.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 763.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,text,"also contains a porous structure design and rapid prototyping technology to provide space for +osteoblast growth and vascular formation and to shorten the whole transplantation process. The +combination","[175.0, 166.0, 1016.0, 380.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,paragraph_title,MATERIALS AND METHODS,"[176.0, 539.0, 423.0, 562.0]",section_heading,0.9,"[""explicit scholarly heading: MATERIALS AND METHODS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +6,5,paragraph_title,Fabrication and characterization of $ \beta $-TCP scaffolds,"[176.0, 601.0, 626.0, 625.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Fabrication and characterization of $ \\beta $-TCP scaffolds""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +6,6,text,"The β-TCP scaffolds were fabricated as previously described $ ^{33} $. Briefly, β-TCP powder was prepared using the chemical precipitation method. Then, ammonium polyacrylate (PAA-NH4) and hydroxyprop","[174.0, 663.0, 1016.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10.0, 85.0, 41.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +7,1,header,ACS Biomaterials Science & Engineering,"[425.0, 19.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,number,Page 6 of 36,"[1069.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,3,text,"volume of the $ \beta $-TCP scaffolds was reduced to 90% after sintering. The design of the scaffold was completed by the CAD software SolidWorks (Massachusetts, USA). The scaffold was coated with go","[174.0, 164.0, 1015.0, 317.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,paragraph_title,Cell culture and PEMF treatment,"[176.0, 352.0, 470.0, 376.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell culture and PEMF treatment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,5,text,"ADSCs were obtained from the groin of 3-day-old Sprague Dawley rats. The cells were cultured on Dulbecco's minimum Eagle's medium (DMEM, Gibco) with 10% fetal bovine serum (FBS, Gibco) and 5% antibiot","[174.0, 415.0, 1016.0, 628.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"The prepared cells were randomly divided into four groups and seeded on tissue culture plates (TCPS) or $ \beta $-TCP scaffolds. The LIVE/DEAD Cell Staining Kit (BioVision, Inc.) was applied to rADSC","[173.0, 665.0, 1016.0, 940.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"The PEMF device (Yongyikeji, Hunan, China) consisted of a generator and its connected coils. When the generator produces a pulse current of a certain intensity, a PEMF will be generated between the co","[173.0, 977.0, 1016.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,CCK-8 and LIVE/DEAD cell staining,"[176.0, 1475.0, 480.0, 1499.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: CCK-8 and LIVE/DEAD cell staining""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,9,footer,ACS Paragon Plus Environment,"[463.0, 1602.0, 728.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 91.0, 44.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +8,1,number,Page 7 of 36,"[13.0, 18.0, 121.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"The CCK-8 assay was performed to evaluate the proliferation of ADSCs under the influence of PEMF and the scaffolds. rADSCs were cultured in basic culture medium for 1, 4 or 7 days on TCPS and $ \beta","[173.0, 165.0, 1016.0, 563.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"LIVE/DEAD cell staining was performed to evaluate the cytotoxicity of the $ \beta $-TCP scaffolds. Each scaffold was washed twice with PBS after 24, 48 and 72 hours, before the working solution was a","[174.0, 601.0, 1016.0, 878.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,paragraph_title,ALP activity and osteogenesis - related gene expression,"[175.0, 913.0, 661.0, 938.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: ALP activity and osteogenesis - related gene expression""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +8,6,text,"To evaluate the osteogenic differentiation of ADSCs, cellular ALP activity was accessed with an alkaline phosphatase assay kit (A059-1, Nanjing Jiancheng Bioengineering Institute, China) after 7 or 14","[174.0, 978.0, 1017.0, 1503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 86.0, 42.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +9,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,2,number,Page 8 of 36,"[1069.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,3,text,"was completed with the cALP Stain Kit (D001-1-1, Nanjing Jiancheng Bioengineering Institute, +China).","[174.0, 164.0, 1015.0, 254.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"The expression of osteogenesis-related genes in the four groups was evaluated by SYBR +Green Real-Time PCR (Thermo Fisher Scientific, Waltham, MA, USA). Total RNA of the ADSCs of +the four groups was is","[173.0, 289.0, 1017.0, 818.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,figure_title,Table 1. Primer sequences used for qRT-PCR.,"[197.0, 851.0, 587.0, 877.0]",table_caption,0.9,"[""table prefix matched: Table 1. Primer sequences used for qRT-PCR.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,6,table,
GeneForward(5′-3′)Reverse(5′-3′)
ALPACCATTCCCACGTCTTCACATTTAGACATTCTCTCGTTCACCGCC
RUNX2ACTTCCTGTGCTCGGTGCT,"[204.0, 911.0, 979.0, 1110.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,unknown_like,none,True,True +9,7,paragraph_title,Surgical operation and PEMF treatment,"[175.0, 1163.0, 529.0, 1188.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Surgical operation and PEMF treatment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,8,text,All the surgical operations were approved by the Ethics Committee of Southern Medical University. Eighteen female Sprague-Dawley rats (180-200 g) were anesthetized with chloral hydrate (300 mg/kg body,"[173.0, 1225.0, 1017.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 89.0, 42.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +10,1,number,Page 9 of 36,"[13.0, 18.0, 121.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,3,text,"mm, on both sides of the parietal bone; physiological saline was added dropwise to help reduce the increase in temperature from the drill. A size matched scaffold, with a diameter of 4.8 mm and a heig","[173.0, 166.0, 1017.0, 441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,"On the third day after the operation, the 18 SD rats were randomly divided into 2 groups. One group was treated with PEMF (50 Hz, 1 mT, 2 hours per day), and the other group, as a control, did not rec","[173.0, 476.0, 1017.0, 877.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,paragraph_title,Micro-CT,"[175.0, 912.0, 264.0, 936.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Micro-CT""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,6,text,The skulls were placed into an X-ray CT scanner for experimental animals (Latheta LCT-200) and scanned with a resolution of 18 $ \mu $m. DICOM images were obtained. Bone mineral density was analyzed ,"[173.0, 975.0, 1017.0, 1249.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,paragraph_title,Histological examination,"[176.0, 1288.0, 400.0, 1313.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histological examination""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +10,8,text,"The free skulls were fixed with formalin for 24 hours and then decalcified with EDTA decalcifying solution (Solarbio, China) for 14 days. The decalcified samples were dehydrated by gradient alcohol an","[173.0, 1349.0, 1017.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,9,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[11.0, 89.0, 41.0, 1517.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +11,1,header,ACS Biomaterials Science & Engineering,"[426.0, 19.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,2,number,Page 10 of 36,"[1060.0, 18.0, 1178.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,3,text,tissue sections. Hematoxylin-eosin staining of the sections was used to stain the nucleus blue and the cytoplasm red.,"[174.0, 164.0, 1014.0, 253.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,paragraph_title,Statistics,"[176.0, 289.0, 262.0, 312.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Statistics""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,5,text,The statistical analyses of this study were completed with SPSS software (Version 20.0). All biological experiments in this study were repeated at least three times. The data were analyzed by one-way ,"[174.0, 352.0, 1015.0, 568.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,paragraph_title,RESULTS AND DISCUSSION,"[176.0, 725.0, 415.0, 749.0]",section_heading,0.9,"[""explicit scholarly heading: RESULTS AND DISCUSSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +11,7,paragraph_title,β-TCP scaffold characterization,"[176.0, 788.0, 454.0, 812.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: \u03b2-TCP scaffold characterization""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +11,8,text,"The surface morphology of the fritted β-TCP scaffolds was observed by SEM (Figure 1a and 1b.), which showed that the structure of the scaffolds was arranged regularly with a bar that was 170±10 μm in ","[173.0, 851.0, 1017.0, 1252.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"The $ \beta $-TCP scaffolds produced by 3D printing technology had great porosity. This property can provide a large number of adhesion areas for cells. When used as a graft, high porosity scaffolds ","[174.0, 1289.0, 1015.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 92.0, 42.0, 1517.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +12,1,number,Page 11 of 36,"[12.0, 18.0, 131.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,3,vision_footnote,beneficial for osteogenesis and angiogenesis.,"[177.0, 163.0, 566.0, 189.0]",footnote,0.7,"[""vision_footnote label: beneficial for osteogenesis and angiogenesis.""]",footnote,0.7,body_zone,body_like,none,True,True +12,4,image,,"[178.0, 206.0, 588.0, 560.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,5,image,,"[598.0, 206.0, 1011.0, 559.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,6,image,,"[179.0, 574.0, 590.0, 922.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,7,image,,"[599.0, 570.0, 1010.0, 922.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,8,figure_title,"Figure 1. SEM images of 3D-printed β-TCP scaffolds: the top panels are (a) 100×, (b) 240× and show that the diameter of the bar is approximately 170±10 microns. The bars are arranged vertically, which","[173.0, 943.0, 1016.0, 1159.0]",figure_caption,0.92,"[""figure_title label: Figure 1. SEM images of 3D-printed \u03b2-TCP scaffolds: the top ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +12,9,paragraph_title,LIVE/DEAD staining,"[175.0, 1256.0, 354.0, 1283.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: LIVE/DEAD staining""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +12,10,text,"To determine the cytocompatibility and cytotoxicity of the scaffolds, we performed the LIVE/DEAD cell staining assay. As the results show (Figure 2.), living cells were dyed green, and dead cells were","[173.0, 1319.0, 1017.0, 1534.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,11,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 84.0, 41.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +13,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,2,number,Page 12 of 36,"[1059.0, 18.0, 1178.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,3,text,"morphology of the rADSCs attached to the scaffold was observed. The ratios of live/dead rADSCs at 24, 48 and 72 hours were 4.36 (Figure 2a, 109/25), 5.81 (Figure 2b, 343/59) and 7.60 (Figure 2c, 251/3","[172.0, 164.0, 1017.0, 441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,image,,"[244.0, 463.0, 624.0, 733.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,5,image,,"[635.0, 464.0, 1011.0, 732.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,6,image,,"[188.0, 742.0, 625.0, 1011.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,7,image,,"[633.0, 744.0, 1012.0, 1012.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,8,image,,"[244.0, 1022.0, 624.0, 1291.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,9,image,,"[634.0, 1023.0, 1011.0, 1291.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,10,figure_title,"Figure 2. LIVE/DEAD staining of rADSCs cultured on scaffolds in ordinary medium for 24, 48 or 72 hours. Live cells are stained green and dead cells are stained red. In the low power field of vision, t","[173.0, 1318.0, 1019.0, 1533.0]",figure_caption,0.92,"[""figure_title label: Figure 2. LIVE/DEAD staining of rADSCs cultured on scaffolds""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +13,11,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[9.0, 95.0, 42.0, 1515.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +14,1,number,Page 13 of 36,"[12.0, 18.0, 130.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,2,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,3,text,"of culture time. In the high-power field of vision, the living cells exhibit a state of expansion in the early stage (b) and elongation in the later stage (f).","[173.0, 164.0, 1015.0, 254.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,4,paragraph_title,CCK-8 assay,"[175.0, 351.0, 288.0, 378.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: CCK-8 assay""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +14,5,text,"As shown in Figure 3, after one day of culture, the proliferation rate of the rADSCs cultured on the scaffold was significantly higher than that of the cells cultured on TCPS, but PEMF treatment had n","[172.0, 415.0, 1018.0, 1317.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,footer,ACS Paragon Plus Environment,"[463.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[9.0, 87.0, 42.0, 1514.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +15,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,2,number,Page 14 of 36,"[1059.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,3,chart,,"[200.0, 182.0, 993.0, 583.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,4,figure_title,"Figure 3. CCK-8 analysis after culture for 1, 4, or 7 days on TCPS or $ \beta $-TCP scaffolds. After 1 day of culture, the proliferation rate of rADSCs cultured on $ \beta $-TCP scaffolds was signif","[172.0, 631.0, 1016.0, 1037.0]",figure_caption,0.92,"[""figure_title label: Figure 3. CCK-8 analysis after culture for 1, 4, or 7 days o""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +15,5,paragraph_title,ALP activity and osteogenesis-related gene expression,"[175.0, 1132.0, 656.0, 1157.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: ALP activity and osteogenesis-related gene expression""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +15,6,text,"ALP activity and ALP staining were used to assess the osteogenic differentiation of rADSCs in the four groups after 14 days of culture. As shown in Figure 4., the ALP activity of the $ \beta $-TCP+PE","[173.0, 1194.0, 1018.0, 1472.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,7,footer,ACS Paragon Plus Environment,"[463.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[8.0, 94.0, 44.0, 1514.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +16,1,number,Page 15 of 36,"[12.0, 18.0, 131.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,3,chart,,"[198.0, 181.0, 995.0, 648.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,4,figure_title,"Figure 4. ALP activity analysis of rADSCs after culture in osteogenic induction medium for 14 days. The activity of ALP in the TCPS+PEMF and $ \beta $-TCP groups was similar, and a significant differ","[173.0, 693.0, 1017.0, 973.0]",figure_caption,0.92,"[""figure_title label: Figure 4. ALP activity analysis of rADSCs after culture in o""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +16,5,text,"Areas of positive ALP staining are shown as purple. As seen from Figure 5a and 5c, the positive area of the TCPS+PEMF group is more disperse than that of the TCPS group, and the coloration is deeper. ","[174.0, 1070.0, 1016.0, 1344.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,footer,ACS Paragon Plus Environment,"[463.0, 1601.0, 727.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[8.0, 83.0, 44.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +17,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 765.0, 46.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,2,number,Page 16 of 36,"[1059.0, 18.0, 1179.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,3,image,,"[190.0, 158.0, 661.0, 398.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,4,image,,"[673.0, 156.0, 1012.0, 396.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,5,image,,"[323.0, 408.0, 662.0, 652.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,6,image,,"[672.0, 409.0, 1011.0, 650.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,7,figure_title,β-TCP,"[348.0, 688.0, 421.0, 720.0]",figure_caption_candidate,0.85,"[""figure_title label: \u03b2-TCP""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +17,8,figure_title,β-TCP+PEMF,"[742.0, 687.0, 890.0, 720.0]",figure_caption,0.85,"[""figure_title label: \u03b2-TCP+PEMF""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +17,9,image,,"[179.0, 751.0, 593.0, 1158.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,10,image,,"[610.0, 750.0, 1011.0, 1157.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,11,figure_title,"Figure 5. ALP staining of rADSCs after culture in osteogenic induction medium for 14 days. (a), (b) rADSCs exposed to PEMF and cultured on TCPS. (c), (d) rADSCs not exposed to PEMF and cultured on TCP","[172.0, 1192.0, 1016.0, 1408.0]",figure_caption,0.92,"[""figure_title label: Figure 5. ALP staining of rADSCs after culture in osteogenic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +17,12,text,qRT-PCR was performed to detect the expression of osteoblast-related genes in cells. As,"[216.0, 1504.0, 1016.0, 1534.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,13,footer,ACS Paragon Plus Environment,"[462.0, 1600.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +18,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 90.0, 42.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +18,1,number,Page 17 of 36,"[12.0, 18.0, 130.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +18,3,text,"shown in Figure 6a, the mean values of ALP and Runx2 expression were the highest in the $ \beta $-TCP+PEMF group after 7 days of culture, and there were significant differences among the groups. Ther","[174.0, 166.0, 1017.0, 503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,4,text,"On the 14th day (Figure 6b.), the expression of ALP, Runx2 and OPN was highest in the $ \beta $-TCP+PEMF group and was significantly higher than that in the other three groups. The expression of OPN ","[174.0, 540.0, 1016.0, 753.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,5,text,"On the 21st day (Figure 6c.), the expression of ALP, Runx2 and OPN in the $ \beta $-TCP+PEMF group was significantly higher than that in the other three groups, and the expression of ALP and Runx2 in","[174.0, 788.0, 1016.0, 1004.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,6,text,"The ALP activity assay showed that the ALP activity of the cells treated with PEMF was significantly increased, and the ALP activity of the cells treated with PEMF was similar to that of the cells tre","[173.0, 1039.0, 1016.0, 1252.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,7,text,"A study by LeGeros, R $ Z^{32} $ et al. showed that calcium phosphate compounds have the following characteristics: similarity to the composition of bone minerals, ability to form a unique bone-calci","[174.0, 1289.0, 1016.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,8,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +19,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10.0, 84.0, 41.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +19,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +19,2,number,Page 18 of 36,"[1059.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,3,text,mechanism by which PEMFs can promote osteogenic differentiation is not completely clear. Wang et al. showed that PEMFs could stimulate osteoblast differentiation by stimulating the sAC-cAMP-PKA-CREB s,"[174.0, 165.0, 1017.0, 754.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,4,figure_title,ALP,"[393.0, 796.0, 440.0, 822.0]",figure_caption,0.85,"[""figure_title label: ALP""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +19,5,chart,,"[196.0, 824.0, 587.0, 1134.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,6,figure_title,Runx2,"[788.0, 796.0, 860.0, 823.0]",figure_caption_candidate,0.85,"[""figure_title label: Runx2""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +19,7,chart,,"[610.0, 828.0, 993.0, 1133.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,8,figure_title,OPN,"[401.0, 1160.0, 451.0, 1187.0]",figure_caption,0.85,"[""figure_title label: OPN""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +19,9,chart,,"[196.0, 1187.0, 907.0, 1497.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,10,footer,ACS Paragon Plus Environment,"[463.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +20,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 89.0, 44.0, 1529.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +20,1,number,Page 19 of 36,"[13.0, 18.0, 131.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +20,3,figure_title,"Figure 6. qRT-PCR analysis was used to evaluate the expression of osteogenesis-related genes in rADSCs cultured in osteogenic induction medium for 7, 14 or 21 days. (a) The expression of ALPin the $ ","[173.0, 165.0, 1017.0, 817.0]",figure_caption,0.92,"[""figure_title label: Figure 6. qRT-PCR analysis was used to evaluate the expressi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +20,4,paragraph_title,Micro CT scanning and hematoxylin-eosin staining,"[175.0, 913.0, 621.0, 938.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Micro CT scanning and hematoxylin-eosin staining""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +20,5,text,"As shown in Figure 7, the bone defect site of the SD rats not treated with PEMF, especially the side without the scaffold, grew slowly and new bone appeared at the edge of the defect site at the eight","[173.0, 978.0, 1016.0, 1441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,6,text,Osteogenic differentiation and angiogenesis are essential for bone regeneration. In addition,"[216.0, 1474.0, 1014.0, 1501.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,7,footer,ACS Paragon Plus Environment,"[463.0, 1601.0, 727.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +21,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10.0, 85.0, 41.0, 1532.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +21,1,header,ACS Biomaterials Science & Engineering,"[425.0, 19.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +21,2,number,Page 20 of 36,"[1059.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,3,text,"to promoting the osteogenic differentiation of stem cells, PEMF therapy can also promote angiogenesis. Yen-Patton, G P $ ^{43} $ et al. used PEMFs to treat endothelial cells of the human umbilical vei","[174.0, 165.0, 1017.0, 567.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,4,footer,ACS Paragon Plus Environment,"[463.0, 1602.0, 728.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +22,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[8.0, 87.0, 45.0, 1528.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +22,1,number,Page 21 of 36,"[11.0, 17.0, 132.0, 45.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,2,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +22,3,image,,"[178.0, 154.0, 1011.0, 1130.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +22,4,figure_title,"Figure 7. 3D reconstruction of the imaging data of SD rats after 0, 4, 8 and 12 weeks of rearing. +The rats in the PEMF group were treated with PEMFs for 2 hours per day, whereas the rats in the withou","[173.0, 1161.0, 1015.0, 1315.0]",figure_caption,0.92,"[""figure_title label: Figure 7. 3D reconstruction of the imaging data of SD rats a""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +22,5,text,"Bone mineral density (BMD) measurements of the new bone were determined in SD rats after 12 weeks. As shown in Figure 8, the highest BMD values were found in the cranial defects","[172.0, 1412.0, 1017.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,6,footer,ACS Paragon Plus Environment,"[461.0, 1600.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +23,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 84.0, 42.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +23,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +23,2,number,Page 22 of 36,"[1059.0, 18.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,3,text,"of rats treated with the scaffold and PEMFs. The cranial defect of rats with the scaffold but without PEMF treatment followed closely. The blank group, which did not receive any treatments, had the lo","[174.0, 164.0, 1016.0, 317.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,4,chart,,"[208.0, 370.0, 988.0, 986.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,5,figure_title,Figure 8. Bone mineral density analysis based on micro-CT data was used to detect the growth of skull defects in SD rats after 12 weeks of rearing. The BMD values of the defect site of rats in the $ ,"[173.0, 1038.0, 1016.0, 1314.0]",figure_caption,0.92,"[""figure_title label: Figure 8. Bone mineral density analysis based on micro-CT da""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +23,6,text,"The results of the HE staining (Figure 9) showed that the implanted scaffold defects possessed good bone mass; however, the rats treated with PEMFs grew thicker bone tissue than","[173.0, 1412.0, 1016.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,7,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +24,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 91.0, 44.0, 1532.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +24,1,number,Page 23 of 36,"[12.0, 18.0, 131.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,2,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +24,3,text,"the rats who had not been treated with PEMFs. In the defect sites without $ \beta $-TCP scaffold implantation, the amount of new bone tissue was reduced, and the new bone tissue structure was more di","[173.0, 164.0, 1016.0, 380.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,4,text,"The BMD results of this study indicate that the BMD values of the defect sites of the rats treated with PEMFs were higher than those of the rats who did not receive PEMF treatment, regardless of wheth","[174.0, 415.0, 1017.0, 878.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,5,footer,ACS Paragon Plus Environment,"[463.0, 1602.0, 728.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +25,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 84.0, 42.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +25,1,header,ACS Biomaterials Science & Engineering,"[425.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +25,2,number,Page 24 of 36,"[1059.0, 18.0, 1178.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +25,3,image,,"[178.0, 154.0, 1010.0, 426.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,4,image,,"[179.0, 491.0, 1010.0, 766.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,5,image,,"[180.0, 829.0, 1009.0, 1107.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,6,image,,"[179.0, 1168.0, 1009.0, 1444.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,7,footer,ACS Paragon Plus Environment,"[462.0, 1601.0, 728.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +26,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 91.0, 41.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +26,1,number,Page 25 of 36,"[12.0, 18.0, 131.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +26,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 763.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +26,3,image,,"[180.0, 146.0, 1010.0, 770.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +26,4,image,,"[180.0, 858.0, 1009.0, 1478.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +26,5,footer,ACS Paragon Plus Environment,"[463.0, 1600.0, 728.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +27,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 84.0, 44.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +27,1,header,ACS Biomaterials Science & Engineering,"[425.0, 17.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +27,2,number,Page 26 of 36,"[1059.0, 18.0, 1178.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +27,3,image,,"[180.0, 145.0, 1010.0, 770.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,4,image,,"[179.0, 856.0, 1010.0, 1479.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,5,figure_title,"Figure 9. HE staining of the cranial defects of rats after 12 weeks of rearing. (A), (E) Rats","[173.0, 1504.0, 1014.0, 1532.0]",figure_caption,0.92,"[""figure_title label: Figure 9. HE staining of the cranial defects of rats after 1""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,True,True +27,6,footer,ACS Paragon Plus Environment,"[461.0, 1600.0, 729.0, 1627.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +28,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9.0, 90.0, 44.0, 1530.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,reference_zone,reference_like,reference_numeric_dot,False,False +28,1,number,Page 27 of 36,"[12.0, 18.0, 131.0, 44.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,2,header,ACS Biomaterials Science & Engineering,"[426.0, 18.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +28,3,text,"implanted with a $ \beta $-TCP scaffold and exposed to PEMFs. (B), (F) Rats implanted with a $ \beta $-TCP scaffold and not exposed to PEMFs. (C), (G) Rats exposed to PEMFs. (D), (H) Rats not expose","[175.0, 163.0, 1017.0, 314.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,4,paragraph_title,CONCLUSION,"[176.0, 475.0, 301.0, 500.0]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +28,5,text,"To summarize, 3D-printed $ \beta $-TCP porous scaffolds have excellent performance in the treatment of skull defects in rats. These scaffolds solve the problems associated with complications and limi","[173.0, 541.0, 1018.0, 1253.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,6,paragraph_title,REFERENCES,"[176.0, 1411.0, 293.0, 1437.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +28,7,reference_content,"(1) Bassett, C. A.; Pawluk, R. J.; Pilla, A. A., Acceleration of fracture repair by electromagnetic","[187.0, 1474.0, 1014.0, 1500.0]",reference_item,0.85,"[""reference content label: (1) Bassett, C. A.; Pawluk, R. J.; Pilla, A. 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I.; Wi, H., Effects of pulsed electromagnetic field on knee osteoarthritis: a systematic review. Rheumatology (Oxford) 2013, 52, (5), 815-24. DOI:10.1093/rheum","[175.0, 1101.0, 1014.0, 1250.0]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +29,10,text,"(8) Bagnato, G. L.; Miceli, G.; Marino, N.; Sciortino, D.; Bagnato, G. F., Pulsed electromagnetic fields in knee osteoarthritis: a double blind, placebo-controlled, randomized clinical trial. 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Interim results of a double-blind trial. LANCET 1984, 1, (8384), 994-6 +(10) de Haas, W. G.;Beaupre, A.;Cameron, H.;English, E., The Canadian experience with pulsed +magnetic fields in","[175.0, 166.0, 1014.0, 374.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +30,4,text,"(11) Khooshideh, M.; Latifi, R. S.; Sheikh, M.; Ghorbani, Y. B.; Shahriari, A., Pulsed Electromagnetic Fields for Postsurgical Pain Management in Women Undergoing Cesarean Section: A Randomized, Doubl","[176.0, 415.0, 1015.0, 625.0]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +30,5,text,"(12) Varani, K.; Vincenzi, F.; Ravani, A.; Pasquini, S.; Merighi, S.; Gessi, S.; Setti, S.; Cadossi, M.; Borea, P. 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J.; Kortekaas, R.; Beersma, D. G.; Schoevers, R. A., Treatment of depression with low-strength transcranial pulsed electromagnetic fields: A mechanistic point of vie","[176.0, 1102.0, 1015.0, 1314.0]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +30,8,text,"(15) Rezaei, K. M.; Tabeie, F.; Sahebjam, F.; Poursani, N.; Jahanbakhsh, N.; Paymanpour, P.; AfsarAski, S., Short-term effects of extremely low-frequency pulsed electromagnetic field and pulsed low-le","[175.0, 1351.0, 1015.0, 1501.0]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +30,9,footer,ACS Paragon Plus Environment,"[462.0, 1602.0, 728.0, 1626.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +31,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[11.0, 92.0, 41.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,reference_zone,reference_like,reference_numeric_dot,False,False +31,1,header,ACS Biomaterials Science & Engineering,"[425.0, 19.0, 764.0, 45.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +31,2,number,Page 30 of 36,"[1060.0, 19.0, 1178.0, 43.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +31,3,text,216-223.DOI:10.1016/j.exer.2016.01.007,"[177.0, 164.0, 533.0, 187.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +31,4,text,"(16) Pena-Philippides, J. C.; Yang, Y.; Bragina, O.; Hagberg, S.; Nemoto, E.; Roitbak, T., Effect of pulsed electromagnetic field (PEMF) on infarct size and inflammation after cerebral ischemia in mic","[175.0, 228.0, 1015.0, 378.0]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +31,5,text,"(17) Leoci, R.; Aiudi, G.; Silvestre, F.; Lissner, E.; Lacalandra, G. M., Effect of pulsed electromagnetic field therapy on prostate volume and vascularity in the treatment of benign prostatic hyperpl","[175.0, 415.0, 1015.0, 626.0]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +31,6,text,"(18) Wang, Y. Y.; Pu, X. Y.; Shi, W. G.; Fang, Q. Q.; Chen, X. R.; Xi, H. R.; Gao, Y. H.; Zhou, J.; Xian, C. J.; Chen, K. 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STEM CELLS INT 2017, 2017, +2450327\.DOI:10\.1155/2017/2450327","[174.0, 164.0, 1015.0, 251.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +32,4,text,"(22) Xie, Y. F.; Shi, W. G.; Zhou, J.; Gao, Y. H.; Li, S. F.; Fang, Q. Q.; Wang, M. G.; Ma, H. P.; Wang, J. +F.; Xian, C. J.; Chen, K. M., Pulsed electromagnetic fields stimulate osteogenic differentia","[174.0, 290.0, 1016.0, 502.0]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +32,5,text,"(23) Yin, Y.; Chen, P.; Yu, Q.; Peng, Y.; Zhu, Z.; Tian, J., The Effects of a Pulsed Electromagnetic Field on the Proliferation and Osteogenic Differentiation of Human Adipose-Derived Stem Cells. 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+ "p2:11", + "p2:12", + "p2:13", + "p2:14", + "p2:15", + "p2:16", + "p2:17", + "p2:18", + "p2:19", + "p2:20", + "p2:21", + "p2:22", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:4", + "p3:5", + "p3:6", + "p3:7", + "p3:8", + "p3:9", + "p3:10", + "p3:11", + "p3:12", + "p3:13", + "p3:14", + "p3:15", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p4:10", + "p4:11", + "p4:12", + "p4:13", + "p4:14", + "p4:15", + "p4:16", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p5:11", + "p5:12", + "p5:13", + "p5:14", + "p5:15", + "p5:16", + "p5:17", + "p5:18", + "p5:19", + "p5:20" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p5:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p6:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_006.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:2", + "p1:17", + "p1:20", + "p2:0", + "p2:1", + "p2:3", + "p2:4", + "p2:7", + "p2:22", + "p3:0", + "p3:1", + "p3:8", + "p3:15", + "p4:0", + "p4:1", + "p4:16", + "p5:0", + "p5:1", + "p5:6" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/2AGGSMVQ/audit_report.md b/audit/2AGGSMVQ/audit_report.md new file mode 100644 index 00000000..d5533096 --- /dev/null +++ b/audit/2AGGSMVQ/audit_report.md @@ -0,0 +1,38 @@ +# OCR Truth Audit Report - 2AGGSMVQ + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 3, 4, 5] +- Reviewed blocks: 98 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/2AGGSMVQ/audit_scope.json b/audit/2AGGSMVQ/audit_scope.json new file mode 100644 index 00000000..52449642 --- /dev/null +++ b/audit/2AGGSMVQ/audit_scope.json @@ -0,0 +1,697 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 3, + 4, + 5 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p2:3", + "p2:4", + "p2:7", + "p2:17", + "p3:2", + "p3:10", + "p3:13", + "p4:2", + "p4:9", + "p4:14", + "p5:5", + "p5:6", + "p5:13", + "p5:14", + "p5:15", + "p5:16", + "p5:17", + "p5:18", + "p5:19", + "p5:20" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + 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null, + "truth_object_id": null, + "truth_reference_membership": null + } + ] +} \ No newline at end of file diff --git a/audit/2AGGSMVQ/block_trace.csv b/audit/2AGGSMVQ/block_trace.csv new file mode 100644 index 00000000..1575f7fd --- /dev/null +++ b/audit/2AGGSMVQ/block_trace.csv @@ -0,0 +1,134 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,doc_title,A Pulsing Electric Field (PEF) Increases Human Chondrocyte Proliferation through a Transduction Pathway Involving Nitric Oxide Signaling,"[66.0, 64.0, 1077.0, 139.0]",paper_title,0.8,"[""page-1 zone title_zone: A Pulsing Electric Field (PEF) Increases Human Chondrocyte P""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,1,text,"Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ James Kronberg, $ ^{2} $ Timothy Ganey, $ ^{3} $ Arthur A. Pilla $ ^{4} $","[67.0, 170.0, 833.0, 195.0]",frontmatter_noise,0.7,"[""keyword-like block: Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ ""]",frontmatter_noise,0.7,body_zone,reference_like,citation_line,False,False +1,2,text," $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite E, Loma Linda, California 92354, $ ^{2} $Healthonics, Inc., Atlanta, Georgia, $ ^{3} $Department of Orthopedic Surgery, Atlanta Medical C","[66.0, 207.0, 1079.0, 269.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,3,text,Received 12 June 2007; accepted 18 October 2007,"[66.0, 278.0, 416.0, 298.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received 12 June 2007; accepted 18 October 2007""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,4,text,Published online 31 January 2008 in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jor.20590,"[66.0, 298.0, 839.0, 318.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Published online 31 January 2008 in Wiley InterScience (www.""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,5,abstract,"ABSTRACT: A potential treatment modality for joint pain due to cartilage degradation is electromagnetic fields (EMF) that can be delivered, noninvasively, to chondrocytes buried within cartilage. A pu","[67.0, 333.0, 1080.0, 614.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,6,text,Keywords: pulsing electric field; chondrocytes; DNA content; nitric oxide; cGMP,"[67.0, 628.0, 686.0, 650.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: pulsing electric field; chondrocytes; DNA content;""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,7,text,"To provide patients with more treatment options for pain management, especially as the population ages, there is a growing need for new methods, drugs, and devices. $ ^{1} $ Joint pain due to injury, ","[66.0, 691.0, 558.0, 828.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,Cartilage tissue has limited capacity for repair following injury. Untreated defects in the cartilage layer of a joint heal poorly or do not heal at all. The tissue degradation that ensues leads inevi,"[65.0, 829.0, 559.0, 1034.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,text,"Noninvasive electromagnetic fields have been shown to reduce musculoskeletal pain and edema with no known side effects. $ ^{5} $ Recently, a capacitively coupled pulsing electric field (PEF) signal ha","[65.0, 1034.0, 559.0, 1309.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,10,text,It is well known that PEMF signals of the type produced by BGS devices can have a physiologically significant effect on tissue growth and repair in animal studies $ ^{7} $ and human clinical trials. $,"[65.0, 1310.0, 560.0, 1381.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,text,"studies7 and human clinical trials.8 Based on these +reports it was hypothesized that PEF signals may be able +to modulate chondrocyte proliferation. It is thus the +primary intent of this study to test ","[583.0, 688.0, 1079.0, 805.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,12,text,It was considered equally important to determine a possible biological pathway by which the PEF signal could exert its action on chondrocytes. This would help establish a set of criteria by which prop,"[583.0, 806.0, 1080.0, 1105.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,13,paragraph_title,MATERIALS AND METHODS,"[586.0, 1126.0, 864.0, 1148.0]",section_heading,0.9,"[""explicit scholarly heading: MATERIALS AND METHODS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,14,text,"Majority of reagents were purchased from Sigma (St. Louis, MO) such as culture media (DMEM, #MT10013CV), calf serum (#B14-401F), and L-NAME (#72760) for inhibition of nitric oxide synthase, LY82583 (#","[583.0, 1150.0, 1078.0, 1341.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,paragraph_title,Cell Culture,"[585.0, 1363.0, 691.0, 1383.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Cell Culture""]",section_heading,0.5,body_zone,body_like,short_fragment,True,True +1,16,text,"Normal human chondrocytes (#CC2550) were obtained from Clonetics subdivision of Lonza (Walkersville, MD). Chondrocytes were grown for expansion in 100-mm culture dishes using DMEM supplemented with 5%","[583.0, 1384.0, 1079.0, 1471.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,footnote,Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909-478-9015; E-mail: biocore1@aol.com),"[66.0, 1406.0, 558.0, 1446.0]",frontmatter_support,0.75,"[""page-1 correspondence footnote: Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909""]",frontmatter_support,0.75,body_zone,body_like,none,True,True +1,18,footnote,"© 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.","[68.0, 1449.0, 559.0, 1471.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2008 Orthopaedic Research Society. Published by Wiley Peri""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,19,number,854,"[69.0, 1478.0, 105.0, 1497.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +1,20,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[131.0, 1479.0, 472.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION,"[444.0, 68.0, 1056.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,1,number,855,"[1083.0, 68.0, 1118.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,text,"calf serum). For experiments, chondrocytes were detached using trypsin, pooled into a single aliquot, counted, and then separated into culture wells using DMEM containing 0.1% calf serum. The use of 0","[106.0, 117.0, 601.0, 496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,paragraph_title,Cell Proliferation,"[108.0, 514.0, 252.0, 534.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell Proliferation""]",subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,False,True +2,4,text,"DNA content of cell layer was used as an index of cell number, and an increase in cell number was used as an indication of increased cell proliferation. The culture media was removed and the cell laye","[107.0, 535.0, 602.0, 685.0]",unknown_structural,0.8,"[""page-1 zone author_zone: DNA content of cell layer was used as an index of cell numbe""]",authors,0.8,body_zone,body_like,none,False,True +2,5,paragraph_title,Nitric Oxide Measurement,"[108.0, 706.0, 329.0, 727.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Nitric Oxide Measurement""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +2,6,text,Nitrite in culture media was measured as an index of nitric oxide levels using the Griess reaction. $ ^{12} $ An aliquot (250 $ \mu $L) of conditioned culture media was collected and measured for nit,"[107.0, 728.0, 600.0, 834.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,cGMP Measurement,"[108.0, 854.0, 278.0, 873.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: cGMP Measurement""]",subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,False,True +2,8,text,The level of cGMP in the cell layer was measured using cGMP Enzyme Immunoassay Kit from Sigma (#CG200-1kt). The culture media was removed and the cell layer rinsed with PBS at 4°C. The cell layer was ,"[107.0, 873.0, 601.0, 1002.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,paragraph_title,PEF Signal,"[108.0, 1023.0, 198.0, 1044.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: PEF Signal""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +2,10,text,"The PEF signal (MedRelief® model SE55, Healthonics Inc, Atlanta, GA) is characterized by a pulse-burst waveform with a primary signal of asymmetrical biphasic rectangular pulses, 210/30 $ \mu $s in e","[106.0, 1045.0, 601.0, 1318.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,paragraph_title,Application of PEF Signal to Cell Culture,"[109.0, 1342.0, 436.0, 1363.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Application of PEF Signal to Cell Culture""]",subsection_heading,0.6,body_zone,body_like,none,True,True +2,12,text,"The PEF signal was delivered by capacitive coupling to chondrocytes using a novel replacement for traditional salt bridges. $ ^{13} $ In this new system, niobium wire jumpers were used instead of salt","[107.0, 1362.0, 602.0, 1470.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,text,"is closely controllable. The resulting vivid, nonfading light +interference colors are used in jewelry, and jeweler’s niobium +is manufactured in standard colors. Importantly for this +application, the h","[625.0, 117.0, 1121.0, 325.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,text,Niobium wire is cut and bent to form bridges between culture wells and the PEF signal passes through these bridges capacitively. Multiple wells are joined together in series. The wire is formed to fit,"[625.0, 326.0, 1120.0, 493.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,text,Preliminary studies found no indication of cytotoxicity when the PEF signal was delivered to either osteoblasts or chondrocytes via the niobium bridge. No changes in temperature or pH were detected in,"[625.0, 494.0, 1121.0, 641.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,16,paragraph_title,Statistics,"[627.0, 660.0, 706.0, 680.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Statistics""]",sub_subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,True,True +2,17,text,For all measures the average value and standard deviation are reported. Number of samples per group was six. Data is expressed as percent of control values. Multiple control bars in a graph indicate c,"[624.0, 682.0, 1122.0, 1061.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: For all measures the average value and standard deviation ar""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,18,paragraph_title,RESULTS,"[628.0, 1081.0, 720.0, 1104.0]",section_heading,0.9,"[""explicit scholarly heading: RESULTS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,19,text,The experimental design was to first investigate whether PEF had an effect on chondrocyte DNA content measured 72 h after PEF treatment. The experimental design then focused on changes in second messe,"[625.0, 1105.0, 1120.0, 1292.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,20,paragraph_title,Effect of Stimuli on Chondrocytes after 72 Hours,"[627.0, 1309.0, 1043.0, 1331.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of Stimuli on Chondrocytes after 72 Hours""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,21,text,A single 30-min treatment period to PEF with an amplitude producing 2.7 microamperes across culture media and an electric field of 0.2 mV/cm significantly increased DNA content by $ 133 \pm 10\% $ (p,"[625.0, 1332.0, 1120.0, 1471.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,22,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[781.0, 1496.0, 1119.0, 1515.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,number,856,"[68.0, 68.0, 105.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,FITZSIMMONS ET AL.,"[135.0, 67.0, 316.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,chart,,"[80.0, 116.0, 546.0, 434.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,"Figure 1. Effect on DNA content after 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In the graph above, PEF signal was ","[66.0, 446.0, 559.0, 628.0]",figure_caption,0.92,"[""figure_title label: Figure 1. Effect on DNA content after 72 h. Normal human cho""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,"Insulin-like growth factor 1 and added calf serum (increases calf serum from 0.1 to 1.0%) also increased DNA content, as shown in Figure 1. A dose response to IGF1 showed higher concentrations (up to ","[66.0, 644.0, 558.0, 783.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Effect of PEF Treatment on Short-Term NO Release,"[67.0, 806.0, 500.0, 827.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of PEF Treatment on Short-Term NO Release""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,6,text,In preliminary studies it was found that PEF could increase NO content transiently within 30 min of initiation of PEF treatment and the elevated NO levels would typically return to control levels shor,"[65.0, 826.0, 559.0, 988.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"To determine pathways involved in response to PEF treatment, chondrocytes were PEF treated in experiments with and without inhibitors. As shown in Figure 2, PEF treatment increased NO levels when meas","[65.0, 988.0, 559.0, 1217.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,In another series of experiments adding either 0.5 mM $ CaCl_{2} $ to the culture media or the calcium ionophore A23187 to 1 mM and measuring NO content of culture media 30 min later showed an increa,"[65.0, 1218.0, 559.0, 1379.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"Effect of PEF Treatment on Short-Term cGMP Generation Nitric oxide acts as a second messenger for the activation of guanylate cyclase (15). Therefore, cGMP was","[66.0, 1401.0, 559.0, 1472.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,chart,,"[598.0, 114.0, 1063.0, 493.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,11,figure_title,Figure 2. PEF signal and short-term (30 min) NO release. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (lig,"[584.0, 503.0, 1079.0, 744.0]",figure_caption,0.92,"[""figure_title label: Figure 2. PEF signal and short-term (30 min) NO release. Nor""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,12,text,"measured in the cell layer after PEF treatment. As shown in Figure 3, PEF treatment increased cGMP within the 30-min treatment period. This effect was blocked by either W7 or by L-NAME, as expected if","[583.0, 772.0, 1081.0, 865.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,chart,,"[598.0, 887.0, 1063.0, 1262.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,14,figure_title,Figure 3. PEF signal increases short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf-serum and allowed to attach and equilibrate for 24 h. In one expe,"[584.0, 1274.0, 1079.0, 1470.0]",figure_caption,0.92,"[""figure_title label: Figure 3. PEF signal increases short-term (30 min) cGMP gene""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,15,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[68.0, 1498.0, 406.0, 1517.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,header,PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION,"[445.0, 67.0, 1056.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,857,"[1083.0, 68.0, 1118.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,chart,,"[122.0, 115.0, 585.0, 442.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,3,figure_title,Figure 4. PEF signal and SNP increase short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. The ,"[107.0, 455.0, 601.0, 650.0]",figure_caption,0.92,"[""figure_title label: Figure 4. PEF signal and SNP increase short-term (30 min) cG""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,4,text,cGMP was increased in a cascade from calmodulin to nitric oxide synthase to cGMP.,"[107.0, 713.0, 600.0, 758.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"In Figure 4, both PEF and a nitric oxide donor (SNP) increased cGMP content of the cell layer within 30 min of treatment. The guanylate cyclase inhibitor (LY83583) blocked both PEF treatment and SNP f","[107.0, 759.0, 601.0, 967.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Effect of Inhibitors on Ability of PEF Treatment to Increase DNA Content at 72 Hours,"[108.0, 991.0, 527.0, 1034.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of Inhibitors on Ability of PEF Treatment to Increase""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,7,text,"In Figure 5, PEF treatment, when applied one time for 30 min, increased chondrocyte proliferation as observed in previous experiments. When L-NAME was added prior to PEF treatment the increase in chon","[107.0, 1035.0, 600.0, 1195.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"Effect of SNP on Chondrocyte Proliferation at 72 Hours +In Figure 6, SNP was added to a final concentration of 150 $ \mu $M, which increased nitric oxide content in culture media to 752 ± 74% of contr","[106.0, 1217.0, 602.0, 1470.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,chart,,"[640.0, 117.0, 1106.0, 476.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,10,figure_title,Figure 5. PEF signal and increased DNA content at 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (ligh,"[627.0, 486.0, 1121.0, 687.0]",figure_caption,0.92,"[""figure_title label: Figure 5. PEF signal and increased DNA content at 72 h. Norm""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,11,text,"content when present for 30 min, which is similar to the profile of NO release with PEF alone.","[626.0, 713.0, 1120.0, 760.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,DISCUSSION,"[629.0, 781.0, 762.0, 803.0]",section_heading,0.9,"[""explicit scholarly heading: DISCUSSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,13,text,Normal tissue regeneration proceeds through a series of phases starting with inflammation $ ^{16} $ and culminating in the deposition and organization of new tissue. In the,"[626.0, 805.0, 1122.0, 875.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,chart,,"[639.0, 895.0, 1105.0, 1259.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,15,figure_title,Figure 6. SNP and PEF effects on DNA. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. Cultures were treated to SNP (an NO donor,"[625.0, 1274.0, 1120.0, 1469.0]",figure_caption,0.92,"[""figure_title label: Figure 6. SNP and PEF effects on DNA. Normal human chondrocy""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,16,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[782.0, 1497.0, 1119.0, 1515.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,number,858,"[69.0, 68.0, 104.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,FITZSIMMONS ET AL.,"[135.0, 68.0, 317.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,text,"case of chronic joint pain, whether due to a prior injury or osteoarthritis, tissue regeneration stalls indefinitely in the inflammation phase. This leads to progressive degeneration of cartilage, irr","[65.0, 117.0, 559.0, 255.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,text,"Cartilage degradation in itself does not translate as a sensory perception directly from the cartilage; joint pain is the symptom that causes patients to seek treatment. Unfortunately, treatments aime","[65.0, 256.0, 559.0, 622.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"This study utilized a PEF signal adapted from the signal used in bone growth stimulators, employed successfully for recalcitrant bone fractures. $ ^{17} $ There are a number of similarities between th","[66.0, 622.0, 558.0, 1034.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,The results of this study also suggest that release of NO is part of the biologic pathway involved in increased DNA content of chondrocyte cultures following PEF treatment. NO increased within the 30-,"[65.0, 1035.0, 559.0, 1287.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,6,text,"Nitric oxide has many influences, $ ^{16,21} $ of which one can be activation of guanylate cyclase, which produces cGMP. $ ^{15} $ This study showed that the PEF signal increased cGMP within the 30-mi","[65.0, 1286.0, 559.0, 1471.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,7,text,"cultures following PEF signal treatment was blocked by +LY83583, thereby indicating cGMP is involved in the +pathway of PEF-stimulated DNA content of chondrocyte +cultures. +I h i i i id l ld b","[583.0, 117.0, 1079.0, 209.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,text,"In these experiments nitric oxide release could be increased with added calcium or a calcium ionophore, which is consistent with reports that NOS can be regulated by calcium. $ ^{23} $ When the calmod","[583.0, 210.0, 1079.0, 415.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,9,text,"Taken together, the data indicates this PEF signal stimulates chondrocyte proliferation through a biological pathway that involves calcium/ calmodulin, nitric oxide synthase, nitric oxide, and cGMP. T","[583.0, 415.0, 1079.0, 759.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"Whether this PEF signal can impart beneficial action to cartilage in human patients, of course, remains to be tested. One limitation of this study is the use of chondrocytes in cell culture, and the o","[583.0, 759.0, 1080.0, 1013.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,paragraph_title,ACKNOWLEDGMENTS,"[587.0, 1037.0, 811.0, 1059.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +5,12,text,"This study was partially funded, and the PEF generators were supplied, by Healthonics Inc., Altanta, GA.","[584.0, 1061.0, 1077.0, 1105.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,paragraph_title,REFERENCES,"[588.0, 1124.0, 714.0, 1146.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +5,14,reference_content,"1. Felson D, Zhang Y. 1998. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 41:1343–1355.","[600.0, 1150.0, 1077.0, 1208.0]",reference_item,0.85,"[""reference content label: 1. Felson D, Zhang Y. 1998. An update on the epidemiology of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,15,reference_content,"2. Department of Health and Human Services. 1991. Aging America: trends and projections. DHHS publication number FC:AJp-28001. Washington, DC: DHHS.","[599.0, 1210.0, 1076.0, 1267.0]",reference_item,0.85,"[""reference content label: 2. Department of Health and Human Services. 1991. Aging Amer""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,16,reference_content,"3. Manek N, Lane N. 2000. Osteoarthritis: current concepts in diagnosis and management. 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Determination of nitrite/nitrate in human biological material by the simple Griess reaction. Clin Chim Acta 274:177–188.","[115.0, 442.0, 598.0, 517.0]",reference_item,0.85,"[""reference content label: 12. Guevara I, Iwanejko J, Dembinska-Kiec A, et al. 1998. De""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,8,reference_content,"13. Kronberg J, Ganey T, Fitzsimmons R. 2006. A novel niobium salt bridge for in vitro PEMF studies. 28th annual meeting, Bioelectromagnetics Society, abstract 11–5.","[114.0, 521.0, 598.0, 578.0]",reference_item,0.85,"[""reference content label: 13. Kronberg J, Ganey T, Fitzsimmons R. 2006. A novel niobiu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,9,reference_content,"14. Ganey T. Personal communication, May 2006.","[116.0, 579.0, 491.0, 598.0]",reference_item,0.85,"[""reference content label: 14. Ganey T. 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Mechanisms and therapeutic applications of time varying and static magnetic fields. In: Barnes F, Greenebaum B, editors. Biological and medical aspects of electromagnetic fields. Bo","[115.0, 721.0, 599.0, 798.0]",reference_item,0.85,"[""reference content label: 17. Pilla A. 2006. Mechanisms and therapeutic applications o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,13,reference_content,"18. DeMattei M, Caruso A, Pezzetti F, et al. 2001. Effects of pulsed electromagnetic fields on human articular chondrocyte proliferation. Connect Tissue Res 42:1–11.","[634.0, 122.0, 1119.0, 180.0]",reference_item,0.85,"[""reference content label: 18. DeMattei M, Caruso A, Pezzetti F, et al. 2001. Effects o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,14,reference_content,"19. Fioravanti A, Nerucci F, Collodel G, et al. 2002. Biochemical and morphological study of human articular chondrocytes cultivated in the presence of pulsed signal therapy. Ann Rheum Dis 61:1032–103","[635.0, 182.0, 1118.0, 259.0]",reference_item,0.85,"[""reference content label: 19. Fioravanti A, Nerucci F, Collodel G, et al. 2002. Bioche""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,15,reference_content,"20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression of neuronal nitric oxide synthase and phospholipase C- $ \gamma $1 in regenerating murine neuronal cells by pulsed electromagnetic field. Exp","[633.0, 262.0, 1118.0, 338.0]",reference_item,0.85,"[""reference content label: 20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,16,reference_content,"21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric oxide and wound repair: role of cytokines. Nitric Oxide 7:1–10.","[632.0, 341.0, 1117.0, 379.0]",reference_item,0.85,"[""reference content label: 21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,17,reference_content,"22. Miura M, Takayama K, Okada J. 1993. Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation. J Physiol 461:513–524.","[633.0, 381.0, 1118.0, 439.0]",reference_item,0.85,"[""reference content label: 22. Miura M, Takayama K, Okada J. 1993. Increase in nitric o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,18,reference_content,"23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J B","[633.0, 442.0, 1119.0, 537.0]",reference_item,0.85,"[""reference content label: 23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxid""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,19,reference_content,"24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/ligand binding kinetics: prediction of bioeffective waveform parameters. Bioelectrochem Bioenerg 48:27–34.","[633.0, 541.0, 1118.0, 598.0]",reference_item,0.85,"[""reference content label: 24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,20,reference_content,"25. Markov MS, Pilla AA. 1997. Weak static magnetic field modulation of myosin phosphorylation in a cell-free preparation: calcium dependence. Bioelectrochem Bioenergetics 43:235–240.","[633.0, 601.0, 1118.0, 676.0]",reference_item,0.85,"[""reference content label: 25. Markov MS, Pilla AA. 1997. Weak static magnetic field mo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,21,reference_content,"26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transduction in electrically stimulated bone cells. J Bone Joint Surg 83-A:1514–1523.","[633.0, 681.0, 1118.0, 737.0]",reference_item,0.85,"[""reference content label: 26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transd""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,22,reference_content,"27. Ciombor DM, Lester G, Aaron RK, et al. 2002. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. J Orthop Res 20:40–50.","[632.0, 741.0, 1120.0, 798.0]",reference_item,0.85,"[""reference content label: 27. Ciombor DM, Lester G, Aaron RK, et al. 2002. 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For experiments, chondrocytes were detached using trypsin, pooled i", + "found_in_fulltext": true, + "fulltext_offset": 5876 + }, + { + "block_id": "p2:3", + "page": 2, + "role": "unknown_structural", + "zone": "frontmatter_side_zone", + "render_default": false, + "snippet": "Cell Proliferation", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:4", + "page": 2, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "DNA content of cell layer was used as an index of cell number, and an increase i", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:5", + "page": 2, + "role": "subsection_heading", + "zone": "frontmatter_side_zone", + "render_default": true, + "snippet": "Nitric Oxide Measurement", + "found_in_fulltext": true, + "fulltext_offset": 6950 + }, + { + "block_id": "p2:6", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Nitrite in culture media was measured as an index of nitric oxide levels using t", + "found_in_fulltext": true, + "fulltext_offset": 6975 + }, + { + "block_id": "p2:7", + "page": 2, + "role": "unknown_structural", + "zone": "frontmatter_side_zone", + "render_default": false, + "snippet": "cGMP Measurement", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:8", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The level of cGMP in the cell layer was measured using cGMP Enzyme Immunoassay K", + "found_in_fulltext": true, + "fulltext_offset": 7286 + }, + { + "block_id": "p2:9", + "page": 2, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "PEF Signal", + "found_in_fulltext": true, + "fulltext_offset": 7596 + }, + { + "block_id": "p2:10", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The PEF signal (MedRelief® model SE55, Healthonics Inc, Atlanta, GA) is characte", + "found_in_fulltext": true, + "fulltext_offset": 7607 + }, + { + "block_id": "p2:11", + "page": 2, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Application of PEF Signal to Cell Culture", + "found_in_fulltext": true, + "fulltext_offset": 8390 + }, + { + "block_id": "p2:12", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The PEF signal was delivered by capacitive coupling to chondrocytes using a nove", + "found_in_fulltext": true, + "fulltext_offset": 8432 + }, + { + "block_id": "p2:13", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "is closely controllable. The resulting vivid, nonfading light interference color", + "found_in_fulltext": true, + "fulltext_offset": 8743 + }, + { + "block_id": "p2:14", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Niobium wire is cut and bent to form bridges between culture wells and the PEF s", + "found_in_fulltext": true, + "fulltext_offset": 9927 + }, + { + "block_id": "p2:15", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Preliminary studies found no indication of cytotoxicity when the PEF signal was ", + "found_in_fulltext": true, + "fulltext_offset": 10392 + }, + { + "block_id": "p2:16", + "page": 2, + "role": "sub_subsection_heading", + "zone": "frontmatter_side_zone", + "render_default": true, + "snippet": "Statistics", + "found_in_fulltext": true, + "fulltext_offset": 10770 + }, + { + "block_id": "p2:18", + "page": 2, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "RESULTS", + "found_in_fulltext": true, + "fulltext_offset": 10784 + }, + { + "block_id": "p2:19", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The experimental design was to first investigate whether PEF had an effect on ch", + "found_in_fulltext": true, + "fulltext_offset": 10792 + }, + { + "block_id": "p2:20", + "page": 2, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Effect of Stimuli on Chondrocytes after 72 Hours", + "found_in_fulltext": true, + "fulltext_offset": 11197 + }, + { + "block_id": "p2:21", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A single 30-min treatment period to PEF with an amplitude producing 2.7 microamp", + "found_in_fulltext": true, + "fulltext_offset": 11246 + }, + { + "block_id": "p2:22", + "page": 2, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:0", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "856", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:1", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "FITZSIMMONS ET AL.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:4", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Insulin-like growth factor 1 and added calf serum (increases calf serum from 0.1", + "found_in_fulltext": true, + "fulltext_offset": 11573 + }, + { + "block_id": "p3:5", + "page": 3, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Effect of PEF Treatment on Short-Term NO Release", + "found_in_fulltext": true, + "fulltext_offset": 11858 + }, + { + "block_id": "p3:6", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In preliminary studies it was found that PEF could increase NO content transient", + "found_in_fulltext": true, + "fulltext_offset": 11907 + }, + { + "block_id": "p3:7", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "To determine pathways involved in response to PEF treatment, chondrocytes were P", + "found_in_fulltext": true, + "fulltext_offset": 12271 + }, + { + "block_id": "p3:8", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In another series of experiments adding either 0.5 mM $ CaCl_{2} $ to the cultur", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:9", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Effect of PEF Treatment on Short-Term cGMP Generation Nitric oxide acts as a sec", + "found_in_fulltext": true, + "fulltext_offset": 13123 + }, + { + "block_id": "p3:12", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "measured in the cell layer after PEF treatment. As shown in Figure 3, PEF treatm", + "found_in_fulltext": true, + "fulltext_offset": 13283 + }, + { + "block_id": "p3:15", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:0", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:1", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "857", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:4", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "cGMP was increased in a cascade from calmodulin to nitric oxide synthase to cGMP", + "found_in_fulltext": true, + 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on Chondrocyte Proliferation at 72 Hours In Figure 6, SNP was adde", + "found_in_fulltext": true, + "fulltext_offset": 15489 + }, + { + "block_id": "p4:11", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "content when present for 30 min, which is similar to the profile of NO release w", + "found_in_fulltext": true, + "fulltext_offset": 16067 + }, + { + "block_id": "p4:12", + "page": 4, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "DISCUSSION", + "found_in_fulltext": true, + "fulltext_offset": 16165 + }, + { + "block_id": "p4:13", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Normal tissue regeneration proceeds through a series of phases starting with inf", + "found_in_fulltext": true, + "fulltext_offset": 16176 + }, + { + "block_id": "p4:16", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + 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"found_in_fulltext": true, + "fulltext_offset": 17487 + }, + { + "block_id": "p5:4", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This study utilized a PEF signal adapted from the signal used in bone growth sti", + "found_in_fulltext": true, + "fulltext_offset": 18331 + }, + { + "block_id": "p5:5", + "page": 5, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "The results of this study also suggest that release of NO is part of the biologi", + "found_in_fulltext": true, + "fulltext_offset": 19281 + }, + { + "block_id": "p5:6", + "page": 5, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Nitric oxide has many influences, $ ^{16,21} $ of which one can be activation of", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:7", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "cultures following PEF signal treatment was blocked by LY83583, thereby indicati", + "found_in_fulltext": true, + "fulltext_offset": 20281 + }, + { + "block_id": "p5:8", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In these experiments nitric oxide release could be increased with added calcium ", + "found_in_fulltext": true, + "fulltext_offset": 20641 + }, + { + "block_id": "p5:9", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Taken together, the data indicates this PEF signal stimulates chondrocyte prolif", + "found_in_fulltext": true, + "fulltext_offset": 21111 + }, + { + "block_id": "p5:10", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Whether this PEF signal can impart beneficial action to cartilage in human patie", + "found_in_fulltext": true, + "fulltext_offset": 21973 + }, + { + "block_id": "p5:11", + "page": 5, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "ACKNOWLEDGMENTS", + "found_in_fulltext": true, + "fulltext_offset": 22563 + }, + { + "block_id": "p5:12", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This study was partially funded, and the PEF generators were supplied, by Health", + "found_in_fulltext": true, + "fulltext_offset": 22581 + }, + { + "block_id": "p5:13", + "page": 5, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "REFERENCES", + "found_in_fulltext": true, + "fulltext_offset": 22689 + }, + { + "block_id": "p5:14", + "page": 5, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. 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"truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:21" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:22" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:23" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:24" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:25" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:26" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:27" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:28" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:29" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:30" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:2", + "p1:5", + "p1:21", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p3:0", + "p3:1", + "p3:2", + "p4:0", + "p4:1", + "p4:2", + "p5:0", + "p5:1", + "p6:0", + "p6:1", + "p6:2", + "p6:3" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/2BYRLKQS/audit_report.md b/audit/2BYRLKQS/audit_report.md new file mode 100644 index 00000000..640dd78a --- /dev/null +++ b/audit/2BYRLKQS/audit_report.md @@ -0,0 +1,39 @@ +# OCR Truth Audit Report - 2BYRLKQS + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 4, 5, 6, 8, 9] +- Reviewed blocks: 124 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/2BYRLKQS/audit_scope.json b/audit/2BYRLKQS/audit_scope.json new file mode 100644 index 00000000..dd902e6e --- /dev/null +++ b/audit/2BYRLKQS/audit_scope.json @@ -0,0 +1,1393 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 4, + 5, + 6, + 8, + 9 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p1:21", + "p4:3", + "p4:8", + "p5:2", + "p5:4", + "p6:9", + "p8:9", + "p8:15", + "p8:16", + "p8:17", + "p8:18", + "p8:19", + "p8:20", + "p8:21", + "p8:22", + "p8:23", + "p8:24", + "p8:25", + "p8:26", + "p8:27", + "p8:28", + "p8:29", + "p8:30", + "p8:31", + "p8:32", + "p8:33", + "p8:34", + "p8:35", + "p8:36", + "p8:37", + "p8:38", + "p8:39", + "p8:40", + "p8:41", + "p8:42", + "p8:43", + "p9:2", + "p9:3", + "p9:4", + "p9:5", + "p9:6", + "p9:7", + "p9:8", + "p9:9", + "p9:10", + "p9:11", + "p9:12", + "p9:13", + "p9:14", + "p9:15", + "p9:16", + "p9:17", + "p9:18", + "p9:19", + "p9:20", + "p9:21", + "p9:22", + "p9:23", + "p9:24", + "p9:25", + "p9:26", + "p9:27", + "p9:28" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:9", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:10", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:11", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:12", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:13", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:14", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + 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+page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,header_image,,"[732.0, 65.0, 1082.0, 135.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,text,RESEARCH ARTICLE,"[116.0, 181.0, 393.0, 211.0]",authors,0.6,"[""page-1 initial-lastname author byline: RESEARCH ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,3,text,Open Access,"[920.0, 184.0, 1073.0, 212.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Open Access""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus),"[109.0, 242.0, 995.0, 396.0]",paper_title,0.8,"[""page-1 zone title_zone: Effects of microcurrent stimulation on Hyaline cartilage rep""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Carla de Campos Ciccone¹, Denise Cristina Zuzzi¹, Lia Mara Grosso Neves¹, Josué Sampaio Mendonça¹, Paulo Pinto Joazeiro² and Marcelo Augusto Marretto Esquisatto¹*","[107.0, 411.0, 980.0, 470.0]",authors,0.8,"[""page-1 zone author_zone: Carla de Campos Ciccone\u00b9, Denise Cristina Zuzzi\u00b9, Lia Mara G""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,paragraph_title,Abstract,"[122.0, 518.0, 208.0, 545.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True +1,7,abstract,"Background: In this study, we investigate the effects of microcurrent stimulation on the repair process of xiphoid cartilage in 45-days-old rats.","[118.0, 555.0, 1056.0, 606.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,8,abstract,"Methods: Twenty male rats were divided into a control group and a treated group. A 3-mm defect was then created with a punch in anesthetized animals. In the treated group, animals were submitted to da","[119.0, 610.0, 1065.0, 730.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,9,abstract,"Results: Basophilia increased gradually in control animals during the experimental period. In treated animals, newly formed cartilage was observed on days 21 and 35. No statistically significant diffe","[119.0, 735.0, 1067.0, 906.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,abstract,Conclusion: We conclude that microcurrent stimulation accelerates the cartilage repair in non-articular site from prepuberal animals.,"[120.0, 911.0, 1041.0, 960.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,11,text,"Keywords: Hyaline cartilage, Tissue repair, Extracellular matrix, Electrotherapy, Immature rats","[118.0, 968.0, 873.0, 995.0]",structured_insert,0.7,"[""keyword-like block: Keywords: Hyaline cartilage, Tissue repair, Extracellular ma""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,12,paragraph_title,Background,"[109.0, 1029.0, 228.0, 1052.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Background""]",section_heading,0.5,body_zone,heading_like,short_fragment,True,True +1,13,text,Most studies on cartilage repair use models of osteochondral defects since these defects are a major public health problem. Although these models permit to monitor the integration of articular cartila,"[106.0, 1054.0, 585.0, 1222.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,text,"Hyaline cartilage is a highly specialized, aneural and avascular connective tissue derived from the embryonic mesenchyme. Morphologically, this tissue is characterized by the presence of a small numbe","[107.0, 1223.0, 585.0, 1271.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,text,"mesenchyme. Morphologically, this tissue is character- +ized by the presence of a small number of cells, called +chondrocytes, which are responsible for the production, +organization and renewal of extra","[603.0, 1029.0, 1081.0, 1222.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,text,"The ECM is formed by a complex of macromolecules including collagens, proteoglycans (PGs) and non-collagen proteins. The interaction of these components ensures that an adequate amount of water is ret","[603.0, 1222.0, 1083.0, 1367.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,footnote,* Correspondence: marcelosquisatto@uniararas.br,"[109.0, 1314.0, 413.0, 1332.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: marcelosquisatto@uniararas.br""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,18,footnote,"Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil","[108.0, 1332.0, 570.0, 1390.0]",footnote,0.7,"[""footnote label: Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biom\u00e9dicas, Centro Uni""]",footnote,0.7,body_zone,body_like,none,True,True +1,19,footnote,Full list of author information is available at the end of the article,"[108.0, 1386.0, 513.0, 1405.0]",footnote,0.7,"[""footnote label: Full list of author information is available at the end of t""]",footnote,0.7,body_zone,body_like,none,True,True +1,20,footer_image,,"[110.0, 1421.0, 336.0, 1467.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +1,21,footer,© 2013 de Campos Ciccone et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/license,"[354.0, 1420.0, 1031.0, 1472.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,1,number,Page 2 of 9,"[997.0, 64.0, 1082.0, 88.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,text,"Chondrocytes are nourished by the diffusion of nutrients through the ECM, either from synovial fluid or from capillaries in the perichondrium [5,6].","[106.0, 176.0, 585.0, 249.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"The cartilaginous ECM consists of fibrillar elements such as collagen and elastin and PGs. The main types of collagen found in cartilage are, in decreasing order, types II, IX and XI. Collagen fibrils","[106.0, 247.0, 587.0, 946.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,Non-articular cartilage differs from articular cartilage by the fact that it is does not suffer the wear and tear of weight-bearing articular cartilage and that the defects induced are chondral and no,"[106.0, 944.0, 586.0, 1281.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"There are various treatment options for articular cartilage defects. Electrical and electromagnetic stimulation and autologous grafts of chondrocytes, mesenchymal cells and biocompatible tissue derive","[106.0, 1280.0, 586.0, 1476.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"Within this context, electrical stimulation as a thera- +peutic strategy for cartilage repair has been little investi- +gated [6,25,26] and knowledge about the response of +cartilage tissue of different ","[602.0, 176.0, 1084.0, 441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"Therefore, the objective of the present study was to investigate the structural and ultrastructural alterations that occur during the healing of non-articular cartilage defects after microcurrent stim","[602.0, 441.0, 1082.0, 561.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,Methods Experimental groups,"[604.0, 582.0, 781.0, 632.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Methods Experimental groups""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,True,True +2,9,footer,,"[604.0, 609.0, 781.0, 632.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,10,text,"1wenty male Wistar rats, 45 days old and weighing 150 to 200 g, were obtained from the Center of Animal Experimentation, Centro Universitário Hermínio Ometto, UNIARARAS. The animals were housed in ind","[601.0, 631.0, 1083.0, 874.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: 1wenty male Wistar rats, 45 days old and weighing 150 to 200""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,11,paragraph_title,Experimental injury,"[604.0, 897.0, 772.0, 920.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Experimental injury""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +2,12,text,"The animals were anesthetized with xylazine hydrochloride (0.2 mg/kg) and ketamine hydrochloride (1 mg/kg). After the ventral region was shaved at the height of the sternum, a 2-cm incision was made i","[602.0, 920.0, 1082.0, 1379.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,paragraph_title,Electrical current stimulation,"[604.0, 1401.0, 845.0, 1423.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrical current stimulation""]",subsection_heading,0.6,body_zone,body_like,none,True,True +2,14,text,Animals of the treated group received daily applications of a biphasic square pulse microgalvanic continuous,"[602.0, 1423.0, 1083.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,Page 3 of 9,"[997.0, 64.0, 1082.0, 88.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,"electrical current during 5 min (Physiotonus Microcurrent© stimulator - Bioset, Rio Claro, Sao Paulo, Brazil). In each application, it was used a frequency of 0.3 Hz and intensity of 20 μA. The pulse ","[106.0, 175.0, 586.0, 683.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,Macroscopic inspection,"[107.0, 704.0, 307.0, 727.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Macroscopic inspection""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,4,text,"Xiphoid cartilage specimens fixed for histochemical analysis were used. The specimens were photographed with a PinePIX 300 digital camera in the front view. Anatomical features, including the appearan","[105.0, 727.0, 586.0, 875.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Histochemistry analysis,"[107.0, 897.0, 306.0, 919.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histochemistry analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,6,text,"After removal, the xiphoid cartilage fragments were fixed in 10% formaldehyde in Millonig buffer, pH 7.4, for 24 h at room temperature. The specimens were then transferred to buffer and processed rout","[106.0, 920.0, 586.0, 1330.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,paragraph_title,Electron microscopy and cytochemistry study,"[107.0, 1353.0, 484.0, 1376.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electron microscopy and cytochemistry study""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,8,text,"The cartilage samples of the two groups were fixed in 2% glutaraldehyde and 0.1% tannic acid dissolved in 0.1 M sodium cacodylate buffer, pH 7.3, for 2 h at room temperature. Next, the material was wa","[106.0, 1376.0, 587.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"and postfixed in 1% osmium tetroxide for 1 h at 4°C. +After this step, the fragments were washed in glycated +saline, treated with 1% uranyl acetate for 18 at 4°C, again +washed in glycated saline, and d","[602.0, 175.0, 1084.0, 634.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,paragraph_title,Morphometric and statistical analysis,"[603.0, 656.0, 914.0, 680.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Morphometric and statistical analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,11,text,"The cartilage repair area was determined on the digitized images as percent reduction of the original defect. Images of longitudinal sections stained with Toluidine blue, Dominici stain and picrosiriu","[602.0, 681.0, 1083.0, 1163.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,paragraph_title,Results,"[604.0, 1182.0, 681.0, 1206.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,13,text,Macroscopic inspection of the wound area showed the circular shape of the defect in control and treated animals and the absence of hemorrhagic or infectious processes at any of the time points studied,"[601.0, 1208.0, 1082.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,text,"Toluidine blue staining (Figure 1) revealed a larger number of connective tissue cells in treated animals on day 7 when compared to the control group. In addition, a higher concentration of connective","[601.0, 1376.0, 1083.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 65.0, 675.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,Page 4 of 9,"[997.0, 65.0, 1082.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,figure_title,Table 1 Morphometric parameters evaluated in the defect area after different periods of time,"[107.0, 176.0, 531.0, 220.0]",table_caption,0.9,"[""table prefix matched: Table 1 Morphometric parameters evaluated in the defect area""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,3,table,"
ParameterTimeControl groupTreated group
7d$ 2.5 \pm 1.1 $$ 2.9 \pm 1.8 $
Lesion r","[107.0, 217.0, 581.0, 751.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,4,vision_footnote,"Measurements were obtained from samples collected on day 7 (7d), day 21 (21d), and day 35 (35d) after experimental injury. Three samples per animal were collected from the central region of the defect","[107.0, 755.0, 567.0, 861.0]",footnote,0.7,"[""vision_footnote label: Measurements were obtained from samples collected on day 7 (""]",footnote,0.7,body_zone,body_like,none,True,True +4,5,text,in central islands was observed in treated animals on day 21. New tissue formation accompanied by intense basophilia at the defect margins was seen in treated animals on day 21 and especially on day 3,"[602.0, 175.0, 1083.0, 513.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,Analysis of sections stained with picrosirius-hematoxylin and examined by bright-field microscopy under polarized light (Figure 2) showed a predominance of thick collagen fibers in the control group a,"[601.0, 513.0, 1083.0, 872.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,Electron photomicrographs of the repair tissue treated by the tannic acid method are shown in Figure 3. Fibroblast-like cells were observed in control animals on days 7 and 21. These cells were surrou,"[602.0, 872.0, 1083.0, 971.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,image,,"[252.0, 1007.0, 937.0, 1373.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,9,figure_title,Figure 1 Photomicrographs of longitudinal sections of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 µA/5 min). Spe,"[115.0, 1377.0, 1068.0, 1462.0]",figure_caption,0.92,"[""figure_title label: Figure 1 Photomicrographs of longitudinal sections of the xi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 675.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,Page 5 of 9,"[997.0, 64.0, 1082.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,image,,"[253.0, 187.0, 936.0, 911.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,Figure 2 Photomicrographs of sections stained with picrosirius-hematoxylin and analyzed by bright-field microscopy under polarized light (D-F and J-L). A-F: Control group; G-L: treated group. Specimen,"[116.0, 919.0, 1059.0, 984.0]",figure_caption,0.92,"[""figure_title label: Figure 2 Photomicrographs of sections stained with picrosiri""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,image,,"[251.0, 1039.0, 938.0, 1391.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,figure_title,Figure 3 Electron photomicrographs of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 μA/5 min). Specimens were coll,"[115.0, 1398.0, 1065.0, 1462.0]",figure_caption,0.92,"[""figure_title label: Figure 3 Electron photomicrographs of the xiphoid cartilage ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,Page 6 of 9,"[997.0, 65.0, 1081.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,2,text,"pericellular matrix that was looser than that seen in the region of the territorial matrix. In contrast, chondroblast-like cells characterized by cytoplasm rich in secretory vesicles and abundant roug","[107.0, 176.0, 586.0, 633.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,3,text,Figure 4 shows electron photomicrographs of the repair tissue submitted to cytochemical staining of PGs. Larger PG complexes were observed in treated animals on day 7 when compared to the control grou,"[106.0, 632.0, 586.0, 898.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 4 shows electron photomicrographs of the repair tissu""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +6,4,paragraph_title,Discussion,"[108.0, 919.0, 216.0, 942.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +6,5,text,"Since non-articular cartilage defects and repair are uncommon in clinical practice, studies investigating these processes are important to gain insights into the reorganization of this tissue under di","[106.0, 944.0, 586.0, 995.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,text,"these processes are important to gain insights into the +reorganization of this tissue under different functional +conditions of the joints. In a recent study, Moyer et al. +[19] observed regeneration of","[602.0, 176.0, 1084.0, 560.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"In the present study, only a small amount of newly formed cartilage was observed at the defect margins in all treated animals after 35 days of uninterrupted microcurrent application. These findings ag","[601.0, 561.0, 1083.0, 872.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,"Another relevant finding was the effect of microcurrent stimulation on the total number of fibroblast cells, which was higher in all treated animals when compared to the respective control group. In a","[601.0, 872.0, 1083.0, 995.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,image,,"[250.0, 1033.0, 946.0, 1390.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,10,figure_title,"Figure 4 Electron photomicrographs of sections from control (A-C) and treated (D-F) animals stained with cuprolinic blue for the detection of proteoglycans (PG). Specimens were collected 7 (A and D), ","[118.0, 1398.0, 1023.0, 1462.0]",figure_caption,0.92,"[""figure_title label: Figure 4 Electron photomicrographs of sections from control ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,Page 7 of 9,"[997.0, 65.0, 1081.0, 88.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,"organization of cartilage in treated animals may be the result of the beneficial effects of electrical stimulation on the production, maintenance and organization of ECM [6,31]. According to Aaron et ","[106.0, 176.0, 586.0, 369.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"Another factor related to the effects of microcurrent stimulation is the induction of the proliferative and differentiation capacity of mesenchymal cells, which are found mainly in young animals [6,32","[106.0, 369.0, 587.0, 729.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"The abundant presence of granulocytes in treated animals on days 7 and 21 is consistent with one of the most well-known effects of electrotherapy, particularly electrical current stimulation, i.e., th","[107.0, 729.0, 587.0, 1209.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,A larger number of birefringent fibers indicating a larger number of compacted collagen fibers were observed in control animals on day 35. The lack of an effect of electrical current stimulation on fi,"[106.0, 1208.0, 587.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"of the healing process by increasing collagen fiber depos- +ition, cell proliferation, growth factor concentration, and +ATP levels. In addition to these observations, Kirsch and +Mercola [40] suggest th","[602.0, 176.0, 1083.0, 417.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"Although the ideal parameters and type of electrical stimulation that is safe and efficient in promoting connective tissue repair, particularly cartilage repair $ [33,44] $, have not been established","[602.0, 416.0, 1083.0, 585.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"In contrast to collagen fibers, the number of elastic fibers seems to be little influenced by microcurrent treatment. Traces of these fibers were observed in the two groups and at the different time p","[602.0, 585.0, 1082.0, 776.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"Several studies on cartilage repair have shown that microcurrents tend to induce the formation of fibrocartilage in chondral defects, whereas osteochondral defects are filled with cartilage tissue sin","[601.0, 776.0, 1083.0, 1112.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,"The adequate combination of collagen fibrils and fibers and highly hydrated PGs permits cartilage to withstand the functional requirements during normal activity [4,47]. In the present study, no diffe","[602.0, 1112.0, 1084.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 66.0, 675.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,Page 8 of 9,"[998.0, 66.0, 1081.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,text,"other hand, the number of stained PGs seems to indicate a positive effect of treatment on the deposition of these molecules in the tissue.","[107.0, 177.0, 584.0, 247.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,The predominance of chondroblast-like cells in the defect area of treated animals since the beginning of treatment highlights another important aspect of the effect of microcurrent stimulation on the ,"[107.0, 248.0, 585.0, 514.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,Conclusion,"[109.0, 537.0, 217.0, 559.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +8,5,text,"We demonstrated that microcurrent stimulation has shown beneficial effects during non-articular cartilage repair in prepuberal animals. However, the period of observation was not sufficient to evaluat","[107.0, 562.0, 585.0, 729.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,paragraph_title,Competing interests,"[110.0, 747.0, 249.0, 764.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing interests""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,7,text,The authors declare that they have no competing interest.,"[109.0, 764.0, 470.0, 783.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,paragraph_title,Authors' contributions,"[109.0, 801.0, 263.0, 819.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Authors' contributions""]",subsection_heading,0.6,body_zone,body_like,none,True,True +8,9,text,"CCC, DCZ and LMGN carried out experimental work, data collection and evaluation, literature search and manuscript preparation. JSM helped the surgical procedure and data collection. PPJ helped to prep","[107.0, 819.0, 583.0, 929.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,paragraph_title,Acknowledgements,"[110.0, 948.0, 245.0, 964.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,11,text,"The authors thank the technicians of the Laboratory of Micromorphology, Centro Universitário Hermínio Ometto, UNIARARAS, and of the Laboratory of Electron Microscopy, Instituto de Biologia, Universida","[108.0, 965.0, 579.0, 1039.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,paragraph_title,Author details,"[110.0, 1055.0, 209.0, 1073.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author details""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,13,text,"¹Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil. ²Departamento de Histologia e ","[109.0, 1073.0, 568.0, 1165.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,14,text,Received: 2 August 2012 Accepted: 16 January 2013 Published: 19 January 2013,"[109.0, 1182.0, 447.0, 1218.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,paragraph_title,References,"[111.0, 1236.0, 188.0, 1254.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +8,16,reference_content,"1. Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW: Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. 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BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[109.0, 66.0, 675.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +9,1,number,Page 9 of 9,"[997.0, 65.0, 1081.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +9,2,reference_content,"31. Lai WM, Sun GA, Ateshian XE, Mow VC: Electrical signals for chondrocytes in cartilage. Biorheology 2002, 39(1):39–45.","[111.0, 181.0, 576.0, 216.0]",reference_item,0.85,"[""reference content label: 31. Lai WM, Sun GA, Ateshian XE, Mow VC: Electrical signals ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,3,reference_content,"32. Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ: Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop Rel Res 2004, 419(1):30–37.","[111.0, 217.0, 563.0, 269.0]",reference_item,0.85,"[""reference content label: 32. Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ: St""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,4,reference_content,"33. Nogami H, Aoki BE, Okagawa T, Mimatsu K: Effects of electric current on chondrogenesis in vitro. Basic science and pathology. Clin Orthop Rel Res 1982, 163:243–247.","[112.0, 271.0, 574.0, 322.0]",reference_item,0.85,"[""reference content label: 33. Nogami H, Aoki BE, Okagawa T, Mimatsu K: Effects of elec""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,5,reference_content,"34. Aaron RK, MacK D, Ciombor DM, Simon BJ: Treatment of nonunions with electric and electromagnetic fields. Clin Orthop 2004, 419(1):21–29.","[112.0, 325.0, 571.0, 360.0]",reference_item,0.85,"[""reference content label: 34. Aaron RK, MacK D, Ciombor DM, Simon BJ: Treatment of non""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,6,reference_content,"35. Westers BM: Review of the repair of defects in articular cartilage. JOSPT 1982, 4:6–15.","[112.0, 361.0, 568.0, 395.0]",reference_item,0.85,"[""reference content label: 35. Westers BM: Review of the repair of defects in articular""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,7,reference_content,"36. Oikhana H, Shimomura Y: Effect of direct current on cultured growth cartilage cells in vitro. J Orthop Res 1988, 6:690–694.","[112.0, 397.0, 553.0, 432.0]",reference_item,0.85,"[""reference content label: 36. Oikhana H, Shimomura Y: Effect of direct current on cult""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,8,reference_content,"37. Davis P: Microcurrent. A modern healthcare modality. 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Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct current-induced repair of articular cartilage in rabbit osteochondral defects. J Orthop Res 1990, 8:266–275.","[111.0, 883.0, 571.0, 935.0]",reference_item,0.85,"[""reference content label: 45. Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,18,reference_content,"46. Black J: Electrical Stimulation of Hard and Soft Tissue in Animal Models. Clin Plast Surg 1985, 12:243–257.","[111.0, 937.0, 572.0, 972.0]",reference_item,0.85,"[""reference content label: 46. Black J: Electrical Stimulation of Hard and Soft Tissue ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,19,reference_content,"47. Reichenberger E, Olsen BR: Collagens as organizers of extracellular matrix during morphogenesis. Semin Cell Dev Biol 1996, 7:631–638.","[112.0, 973.0, 577.0, 1008.0]",reference_item,0.85,"[""reference content label: 47. Reichenberger E, Olsen BR: Collagens as organizers of ex""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,20,reference_content,"48. Takei N, Akai M: Effect of direct current stimulation on triradiate physeal cartilage. In vivo study in young rabbits. Arch Orthop Trauma Surg 1993, 112:159–162.","[113.0, 1010.0, 574.0, 1061.0]",reference_item,0.85,"[""reference content label: 48. Takei N, Akai M: Effect of direct current stimulation on""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,21,text,"doi:10.1186/1472-6882-13-17 +Cite this article as: de Campos Ciccone et al.: Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus). 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BMC Complementary and Alternative Medicine 2013, 13:17 ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:1", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Page 6 of 9", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:2", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "pericellular matrix that was looser than that seen in the region of the territor", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:3", + "page": 6, + "role": "body_paragraph", + "zone": "display_zone", + "render_default": true, + "snippet": "Figure 4 shows electron photomicrographs of the repair tissue submitted to cytoc", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:4", + "page": 6, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Discussion", + "found_in_fulltext": true, + "fulltext_offset": 15533 + }, + { + "block_id": "p6:5", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Since non-articular cartilage defects and repair are uncommon in clinical practi", + "found_in_fulltext": true, + "fulltext_offset": 15544 + }, + { + "block_id": "p6:6", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "these processes are important to gain insights into the reorganization of this t", + "found_in_fulltext": true, + "fulltext_offset": 15650 + }, + { + "block_id": "p6:7", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In the present study, only a small amount of newly formed cartilage was observed", + "found_in_fulltext": true, + "fulltext_offset": 17429 + }, + { + "block_id": "p6:8", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Another relevant finding was the effect of microcurrent stimulation on the total", + "found_in_fulltext": true, + "fulltext_offset": 18129 + }, + { + "block_id": "p7:0", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:1", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Page 7 of 9", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:2", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "organization of cartilage in treated animals may be the result of the beneficial", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:3", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Another factor related to the effects of microcurrent stimulation is the inducti", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:4", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The abundant presence of granulocytes in treated animals on days 7 and 21 is con", + "found_in_fulltext": true, + "fulltext_offset": 18451 + }, + { + "block_id": "p7:5", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A larger number of birefringent fibers indicating a larger number of compacted c", + "found_in_fulltext": true, + "fulltext_offset": 19518 + }, + { + "block_id": "p7:6", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "of the healing process by increasing collagen fiber depos- ition, cell prolifera", + "found_in_fulltext": true, + "fulltext_offset": 20659 + }, + { + "block_id": "p7:7", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Although the ideal parameters and type of electrical stimulation that is safe an", + "found_in_fulltext": true, + "fulltext_offset": 21254 + }, + { + "block_id": "p7:8", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In contrast to collagen fibers, the number of elastic fibers seems to be little ", + "found_in_fulltext": true, + "fulltext_offset": 21655 + }, + { + "block_id": "p7:9", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Several studies on cartilage repair have shown that microcurrents tend to induce", + "found_in_fulltext": true, + "fulltext_offset": 22053 + }, + { + "block_id": "p7:10", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The adequate combination of collagen fibrils and fibers and highly hydrated PGs ", + "found_in_fulltext": true, + "fulltext_offset": 22845 + }, + { + "block_id": "p8:0", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:1", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Page 8 of 9", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:2", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "other hand, the number of stained PGs seems to indicate a positive effect of tre", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:3", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The predominance of chondroblast-like cells in the defect area of treated animal", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:4", + "page": 8, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Conclusion", + "found_in_fulltext": true, + "fulltext_offset": 1832 + }, + { + "block_id": "p8:5", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "We demonstrated that microcurrent stimulation has shown beneficial effects durin", + "found_in_fulltext": true, + "fulltext_offset": 23698 + }, + { + "block_id": "p8:6", + "page": 8, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Competing interests", + "found_in_fulltext": true, + "fulltext_offset": 24065 + }, + { + "block_id": "p8:7", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The authors declare that they have no competing interest.", + "found_in_fulltext": true, + "fulltext_offset": 24087 + }, + { + "block_id": "p8:8", + "page": 8, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Authors' contributions", + "found_in_fulltext": true, + "fulltext_offset": 24149 + }, + { + "block_id": "p8:9", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "CCC, DCZ and LMGN carried out experimental work, data collection and evaluation,", + "found_in_fulltext": true, + "fulltext_offset": 24172 + }, + { + "block_id": "p8:10", + "page": 8, + "role": "sub_subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Acknowledgements", + "found_in_fulltext": true, + "fulltext_offset": 24584 + }, + { + "block_id": "p8:11", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The authors thank the technicians of the Laboratory of Micromorphology, Centro U", + "found_in_fulltext": true, + "fulltext_offset": 24603 + }, + { + "block_id": "p8:12", + "page": 8, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Author details", + "found_in_fulltext": true, + "fulltext_offset": 24854 + }, + { + "block_id": "p8:13", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "¹Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio", + "found_in_fulltext": true, + "fulltext_offset": 24869 + }, + { + "block_id": "p8:14", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Received: 2 August 2012 Accepted: 16 January 2013 Published: 19 January 2013", + "found_in_fulltext": true, + "fulltext_offset": 25207 + }, + { + "block_id": "p8:15", + "page": 8, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": true, + "fulltext_offset": 25427 + }, + { + "block_id": "p8:16", + "page": 8, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. 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reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:22", + "p1:23", + "p2:0", + "p2:1", + "p3:0", + "p3:1", + "p3:7", + "p3:14", + "p4:0", + "p4:1", + "p4:3", + "p5:0", + "p5:1", + "p6:0" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/2E4EPHN2/audit_report.md b/audit/2E4EPHN2/audit_report.md new file mode 100644 index 00000000..abd8fadd --- /dev/null +++ b/audit/2E4EPHN2/audit_report.md @@ -0,0 +1,37 @@ +# OCR Truth Audit Report - 2E4EPHN2 + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 5, 6, 7, 8, 9, 11, 12] +- Reviewed blocks: 136 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/2E4EPHN2/audit_scope.json b/audit/2E4EPHN2/audit_scope.json new file mode 100644 index 00000000..8849f477 --- /dev/null +++ b/audit/2E4EPHN2/audit_scope.json @@ -0,0 +1,1165 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 5, + 6, + 7, + 8, + 9, + 11, + 12 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p1:21", + "p1:22", + "p1:23", + "p5:2", + "p5:6", + "p6:3", + "p6:7", + "p6:8", + "p6:11", + "p6:13", + "p7:5", + "p7:7", + "p7:8", + "p7:11", + "p7:12", + "p8:3", + "p8:5", + "p8:6", + "p8:8", + "p8:10", + "p8:13", + "p8:14", + "p8:16", + "p9:5", + "p9:7", + "p9:8", + "p9:10", + "p9:12", + "p11:0", + "p11:2", + "p11:4", + "p11:5", + "p11:6", + "p11:7", + "p11:8", + "p12:5", + "p12:6", + "p12:10", + "p12:11", + "p12:12", + "p12:13", + "p12:14", + "p12:15", + "p12:16", + "p12:17", + "p12:18", + "p12:19", + "p12:20" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + 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role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,Microcurrent and Gold Nanoparticles Combined with Hyaluronic Acid Accelerates Wound Healing,"[65.0, 232.0, 959.0, 313.0]",paper_title,0.8,"[""page-1 zone title_zone: Microcurrent and Gold Nanoparticles Combined with Hyaluronic""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Carolini Mendes 1,2, Anand Thirupathi 1,*⊕, Rubya Pereira Zaccaron 2, Maria Eduardo Anastácio Borges Corrêa 2, João V. S. Bittencourt 2, Laura de Roch Casagrande 2, Anadhelly C. S. de Lima 2, Lara L. ","[64.0, 334.0, 1108.0, 437.0]",authors,0.8,"[""page-1 zone author_zone: Carolini Mendes 1,2, Anand Thirupathi 1,*\u2295, Rubya Pereira Za""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text," $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningbo 315211, China","[326.0, 478.0, 842.0, 501.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningb""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,7,text," $ ^{2} $ Laboratory of Experimental Phisiopatology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Cricúima 88806-000, Brazil","[326.0, 501.0, 1121.0, 543.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $ Laboratory of Experimental Phisiopatology, Program ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,8,text," $ ^{3} $ Graduate Program of Biomedical Science, Herminio Ometto Foundation, Araras 13607-339, Brazil","[327.0, 544.0, 1051.0, 566.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{3} $ Graduate Program of Biomedical Science, Herminio Om""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,9,image,,"[69.0, 733.0, 178.0, 770.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,10,text,"Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corrêa, M.E.A.B.; Bittencourt, J.V.S.; Casagrande, L.d.R.; de Lima, A.C.S.; de Oliveira, L.L.; de Andrade, T.A.M.; Gu, Y.; et al. Microcurrent and","[65.0, 778.0, 308.0, 1037.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corr\u00eaa""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,image,,"[69.0, 1313.0, 185.0, 1353.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,12,text,Academic Editor: Reinhart M. Speeckaert,"[67.0, 1052.0, 260.0, 1097.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic Editor: Reinhart M. Speeckaert""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,13,text,"Received: 16 September 2022 +Accepted: 7 November 2022 +Published: 15 November 2022","[67.0, 1114.0, 259.0, 1183.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 16 September 2022\nAccepted: 7 November 2022\nPublis""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,14,text,"Publisher's Note: MDPI stays neutral +with regard to jurisdictional claims in +published maps and institutional affiliations. +* Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.)","[66.0, 1197.0, 307.0, 1289.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Publisher's Note: MDPI stays neutral\nwith regard to jurisdic""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,15,text,* Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.),"[327.0, 567.0, 885.0, 589.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.n""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,16,text,"Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66.0, 1363.0, 309.0, 1551.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2022 by the authors. Licensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,17,abstract,Abstract: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. Fifty Wistar rats (n = 10,"[326.0, 614.0, 1125.0, 1105.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,18,text,Keywords: wound healing; iontophoresis; gold nanoparticles; hyaluronic acid; inflammation,"[327.0, 1133.0, 1072.0, 1158.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: wound healing; iontophoresis; gold nanoparticles; ""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,19,paragraph_title,1. Introduction,"[328.0, 1232.0, 473.0, 1255.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,20,text,"Currently, the prevalence of non-healing wounds in developed countries is 1 to 2%, and this rate is significantly increased in underdeveloped countries. However, this problem affects the population in","[325.0, 1263.0, 1125.0, 1462.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,21,text,"New materials and approaches are urgently desirable for wound healing since current treatments are closely restricted to bed hygiene and dressing changes; although essential, in some situations, these","[324.0, 1464.0, 1126.0, 1542.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,22,footer,"Antioxidants 2022, 11, 2257. https://doi.org/10.3390/antiox11112257","[66.0, 1625.0, 557.0, 1647.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,23,footer,https://www.mdpi.com/journal/antioxidants,"[784.0, 1625.0, 1122.0, 1648.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,2 of 15,"[1068.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,2,text,"it is important to develop other approaches that accelerate the acute inflammatory and re-epithelialization process, thus avoiding complications and excessive expenditures in the health system [6,7].","[325.0, 192.0, 1123.0, 266.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"A microcurrent (MC) or a microgalvanic current is an electrical current in the range of microamperes ( $ \mu $A), polarized and continuous, and it promotes a physical stimulus and is non-invasive, non","[326.0, 268.0, 1125.0, 468.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Furthermore, through electrophoresis and electro-osmosis, MC allows the passage of charged and uncharged biomolecules across biological membranes. Iontophoresis is the collective name for these two pr","[326.0, 469.0, 1124.0, 669.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Currently, the development of nanomaterials, such as gold nanoparticles (GNPs), represents a promising approach to wound care [17]. Due to their focused delivery, lower toxicity, and higher absorption","[326.0, 670.0, 1124.0, 921.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"Hyaluronic acid (HA) is a component of the extracellular matrix, and it has excellent benefits for the treatment of dermal and epidermal lesions [22]. Its capacity to promote the production of fibrin,","[325.0, 920.0, 1124.0, 1274.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,2. Materials and Methods,"[328.0, 1291.0, 569.0, 1315.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,8,paragraph_title,2.1. Animals,"[328.0, 1318.0, 443.0, 1342.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Animals""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,text,"All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (Bethesda, MD, USA) and with t","[326.0, 1349.0, 1123.0, 1474.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,"Fifty Wistar male rats (60 days old, weighing between 250 and 300 g) were used, and they were kept at a controlled room temperature between $ 20 \pm 22\ ^{\circ}\mathrm{C} $, under a light-dark","[326.0, 1475.0, 1123.0, 1527.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,3 of 15,"[1068.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,2,text,"cycle 12/12 h, and with free access to water and food. Male rats were used so that there were no changes in the inflammatory analysis due to hormones.","[324.0, 192.0, 1122.0, 242.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,The animals were randomly assigned to five experimental groups with n = 10/group: excisional wound (EW) group—without local or systemic treatment; the EW + microcurrent treatment (EW + MC) group (300 ,"[326.0, 244.0, 1124.0, 369.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,paragraph_title,2.2. Excisional Wound Model,"[328.0, 387.0, 578.0, 410.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Excisional Wound Model""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,5,text,"The wound model was made using a circular excision as described by Mendes [21]. The animals were anesthetized with 4% isoflurane. The dorsal region of each animal was shaved, cleaned, and disinfected ","[325.0, 417.0, 1125.0, 546.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,2.3. Treatment,"[328.0, 564.0, 455.0, 588.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Treatment""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,7,text,"The animals received microcurrent treatment using a Ibramed Striat Esthetic $ ^{\circledR} $ (Ibramed, São Paulo, Brazil) device with the function of a microgalvanic ( $ \mu $A) current lasting 20 min","[326.0, 594.0, 1125.0, 720.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"The first treatment session started 24 h after the injury, and the others were performed daily until the seventh day. The area treated with iontophoresis was the dorsal region, which was submitted to ","[326.0, 720.0, 1124.0, 848.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,2.4. Euthanasia,"[328.0, 865.0, 465.0, 890.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Euthanasia""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,10,text,"The animals were euthanized 12 h after the last application of the MC, HA, and/or GNPs. After that, the external border of the wound was surgically removed and immediately processed and stored in a fr","[326.0, 897.0, 1124.0, 974.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,2.5. Synthesis and Characterization of the GNPs,"[328.0, 992.0, 728.0, 1017.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Synthesis and Characterization of the GNPs""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,12,text,"Next, 20 nm GNPs were synthesized using the Turkevish method adapted by Della Vechia et al. [25]. The GNP solution was characterized using ultraviolet–visible (UV–VIS) spectroscopy with a spectrophoto","[325.0, 1023.0, 1124.0, 1199.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,paragraph_title,2.6. Wound Size Analysis,"[328.0, 1217.0, 546.0, 1242.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Wound Size Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,14,text,"Digital images of the wounds were taken at a resolution of $ 3264 \times 2448 $ pixels and analyzed using ImageJ $ ^{\textregistered} $ 1.51 software (National Institute of Mental Health, Bethesda, M","[326.0, 1249.0, 1124.0, 1400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,paragraph_title,2.7. Histomorphometry,"[328.0, 1420.0, 526.0, 1445.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Histomorphometry""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,16,text,"The wound samples of four animals per group were conditioned for 48 h in a 10% formaldehyde-buffered solution (pH 7.4 phosphate buffer), followed by histological processing, and they were then embedde","[326.0, 1450.0, 1124.0, 1553.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,4 of 15,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,2,text,"inflammatory infiltrate, blood vessels, and fibroblasts. Moreover, Ponceau S staining was performed to quantify the percentage area of total collagen compaction [29–32].","[325.0, 192.0, 1122.0, 242.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"Furthermore, all histological sections were visualized using a LEICA $ ^{\circledR} $ DM-2000B optical microscope with a LEICA $ ^{\circledR} $ DFC-300 FX (Leica Microsystems, Wetzlar, Germany) camera","[326.0, 242.0, 1123.0, 341.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,text,"For a simultaneous quantification (evaluated by a trained pathologist) of the inflammatory infiltrate and fibroblasts, the “Cell Counter” plugin in ImageJ software (5 images/animal/time/treatment in 4","[326.0, 343.0, 1126.0, 520.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,paragraph_title,2.8. Determination of Cytokine Content Using ELISA,"[328.0, 537.0, 774.0, 562.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Determination of Cytokine Content Using ELISA""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,6,text,"The samples were processed, and then the plate was sensitized for further incubation with the antibody. To measure cytokines (IFN $ \gamma $, TNF- $ \alpha $, IL-1 $ \beta $, IL-6, IL-4, IL-10, TGF- $","[326.0, 569.0, 1124.0, 671.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,paragraph_title,2.9. Biochemical Analysis,"[328.0, 688.0, 545.0, 713.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Biochemical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,8,text,"Tissue determination of Reactive Oxygen Species (ROS) and nitric oxide: The production of hydroperoxides was determined by the intracellular formation of 2',7' dichlorofluorescein (DCF) by ROS as desc","[326.0, 720.0, 1124.0, 820.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,Tissue determination of oxidative damage marker levels: The oxidative damage to protein in the homogenized skin tissue samples was measured by the determination of carbonyl groups. The total thiol con,"[326.0, 822.0, 1124.0, 920.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,"Tissue determination of antioxidant defenses: SOD was measured in homogenized skin tissue by the inhibition of adrenaline oxidation, which was adapted from Bannister and Calabrese [35]. A standard cur","[326.0, 921.0, 1123.0, 1020.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,Protein Content: The protein content in homogenized skin tissue was measured following the protocol from Corrêa et al. [34].,"[327.0, 1021.0, 1121.0, 1072.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,2.10. Statistical Analysis,"[328.0, 1091.0, 540.0, 1115.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,13,text,"Data are expressed as the mean ± standard error, and they were analyzed statistically using one-way analysis of variance (ANOVA) tests, followed by Tukey's post hoc tests. The significance level for t","[326.0, 1122.0, 1123.0, 1225.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,paragraph_title,3. Results,"[328.0, 1244.0, 426.0, 1266.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,15,paragraph_title,3.1. Physicochemical Properties of the GNP Solution,"[328.0, 1269.0, 760.0, 1295.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Physicochemical Properties of the GNP Solution""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,16,text,"To evaluate the formation and physical–chemical properties of the GNPs, UV–VIS, DLS, and zeta potential analyses were performed. The GNPs presented a maximum absorption peak at 524 nm and a ruby red c","[326.0, 1301.0, 1124.0, 1501.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,5 of 15,"[1069.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,2,chart,,"[334.0, 191.0, 1100.0, 572.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,Figure 1. UV–VIS spectroscopy (A) and TEM images (B) of the GNP solution were obtained.,"[327.0, 590.0, 1065.0, 614.0]",figure_caption,0.92,"[""figure_title label: Figure 1. UV\u2013VIS spectroscopy (A) and TEM images (B) of the ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,paragraph_title,3.2. Analysis of the Wound Contraction Rate,"[328.0, 629.0, 703.0, 654.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Analysis of the Wound Contraction Rate""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,5,text,"We evaluated the wound contraction rate in %, represented by the reduction in the surface area (Figure 2), where all treated groups showed a significant difference compared to the control group.","[326.0, 660.0, 1122.0, 737.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,chart,,"[186.0, 756.0, 1015.0, 1034.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,7,figure_title,"Figure 2. Effects of treatment with MC, GNPs, and hyaluronic acid on wound contraction. The data are presented in mean ± EPM, in which **p < 0.01 vs. excisional wound group (EW) and ***p < 0.001 vs. e","[326.0, 1056.0, 1121.0, 1133.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,8,paragraph_title,3.3. Histological Analysis,"[328.0, 1148.0, 546.0, 1172.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Histological Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,9,text,"In Figures 3 and 4, representative images of the histological sections of the integumentary system can be seen. A decrease in the mean number of inflammatory infiltrates was found in the EW + MC group","[326.0, 1180.0, 1124.0, 1303.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"Despite analyzing the percentage of collagen area (Figure 4B), no significant difference was observed between the groups.","[326.0, 1304.0, 1123.0, 1354.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,0,header,"Antioxidants 2022, 11, 2257","[66.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,6 of 15,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,2,figure_title,A),"[334.0, 189.0, 365.0, 221.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,3,image,,"[368.0, 200.0, 1078.0, 365.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,4,vision_footnote,"■ Excisional Wound (EW) +■ EW + MC +■ EW + MC + HA +■ EW + MC + GNPs +■ EW + MC + HA + GNPs","[569.0, 383.0, 885.0, 545.0]",footnote,0.7,"[""vision_footnote label: \u25a0 Excisional Wound (EW)\n\u25a0 EW + MC\n\u25a0 EW + MC + HA\n\u25a0 EW + MC +""]",footnote,0.7,body_zone,unknown_like,none,True,True +6,5,figure_title,B),"[333.0, 546.0, 364.0, 577.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,6,figure_title,C),"[705.0, 547.0, 735.0, 577.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,7,chart,,"[337.0, 550.0, 701.0, 799.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,chart,,"[717.0, 552.0, 1055.0, 797.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,figure_title,"Figure 3. (A) Representative images of the histological sections of the integumentary system. (B,C) Effects of treatment with MC, GNPs, and hyaluronic acid on the number of inflammatory infiltrates (B","[326.0, 813.0, 1125.0, 917.0]",figure_caption,0.92,"[""figure_title label: Figure 3. (A) Representative images of the histological sect""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,10,figure_title,A),"[332.0, 930.0, 363.0, 958.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,11,image,,"[353.0, 939.0, 1098.0, 1110.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,12,figure_title,B),"[333.0, 1122.0, 365.0, 1154.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,13,chart,,"[338.0, 1125.0, 1107.0, 1422.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,14,figure_title,"Figure 4. (A) Representative images of the histological sections of the integumentary system. (B) Effects of treatment with MC, GNPs, and hyaluronic acid on the % of collagen area. The data are presen","[326.0, 1439.0, 1125.0, 1515.0]",figure_caption,0.92,"[""figure_title label: Figure 4. (A) Representative images of the histological sect""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,0,header,"Antioxidants 2022, 11, 2257","[66.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,7 of 15,"[1068.0, 110.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,2,paragraph_title,3.4. Evaluation of Pro-Inflammatory Cytokines,"[327.0, 192.0, 717.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Evaluation of Pro-Inflammatory Cytokines""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,3,text,"Figure 5 shows the protein levels of pro-inflammatory cytokines. In Figure 5A, INFγ levels decreased in the EW + MC + HA group (p < 0.05) and in the combined therapy group (p < 0.01) when compared to ","[325.0, 224.0, 1126.0, 400.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 5 shows the protein levels of pro-inflammatory cytoki""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +7,4,figure_title,A,"[334.0, 417.0, 356.0, 439.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,5,chart,,"[339.0, 418.0, 666.0, 627.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,6,figure_title,B,"[677.0, 417.0, 696.0, 438.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,7,chart,,"[680.0, 422.0, 1013.0, 625.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,8,chart,,"[601.0, 638.0, 810.0, 755.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,9,figure_title,C,"[333.0, 766.0, 353.0, 787.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,10,figure_title,D,"[676.0, 766.0, 697.0, 787.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,11,chart,,"[339.0, 782.0, 663.0, 983.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,12,chart,,"[693.0, 784.0, 1011.0, 982.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,"Figure 5. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of pro-inflammatory cytokines: (A) INF-Y, (B) TNF-α, (C) IL1-β, (D) IL6. The data are presented in mean ± EPM, i","[325.0, 995.0, 1124.0, 1123.0]",figure_caption,0.92,"[""figure_title label: Figure 5. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,14,paragraph_title,3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Factors,"[327.0, 1138.0, 892.0, 1163.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Fa""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,15,text,The protein levels of anti-inflammatory cytokines are shown in Figure 6. The levels of IL-4 (Figure 6A) and IL10 (Figure 6B) were increased in the EW + MC + HA and EW + MC + HA + GNPs groups in relati,"[326.0, 1171.0, 1124.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,16,text,The group treated with only the microcurrent (EW + MC) and the group in which the therapies were combined (EW + MC + HA + GNPs) showed a significant increase in the levels of TGF- $ \beta $ (Figure 6C,"[326.0, 1245.0, 1124.0, 1370.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,17,paragraph_title,3.6. Intracellular Determination of Oxidants,"[328.0, 1389.0, 699.0, 1414.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.6. Intracellular Determination of Oxidants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,18,text,It can be seen that only the group treated with the combined therapies (EW + MC + HA + GNPs) had their oxidant levels of DCFH (Figure 7A) and nitrite (Figure 7B) decreased when compared to the control,"[326.0, 1419.0, 1124.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"Antioxidants 2022, 11, 2257","[66.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 15,"[1068.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,figure_title,A,"[335.0, 191.0, 357.0, 215.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,3,chart,,"[338.0, 194.0, 659.0, 399.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,4,figure_title,B,"[677.0, 191.0, 697.0, 214.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,5,chart,,"[682.0, 202.0, 1004.0, 398.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,6,chart,,"[591.0, 410.0, 801.0, 529.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,7,figure_title,C,"[332.0, 536.0, 353.0, 558.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,8,chart,,"[337.0, 546.0, 660.0, 744.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,D,"[677.0, 537.0, 698.0, 558.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,10,chart,,"[682.0, 550.0, 1003.0, 743.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,11,figure_title,"Figure 6. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of anti-inflammatory cytokines: (A) IL4; (B) IL10; (C) TGF- $ \beta $; (D) FGF. The data are presented in mean ","[326.0, 755.0, 1125.0, 859.0]",figure_caption,0.92,"[""figure_title label: Figure 6. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,12,figure_title,A,"[333.0, 876.0, 356.0, 902.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,13,chart,,"[335.0, 888.0, 768.0, 1146.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,14,chart,,"[789.0, 941.0, 1016.0, 1220.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,15,figure_title,B,"[333.0, 1167.0, 355.0, 1191.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,16,chart,,"[354.0, 1179.0, 763.0, 1430.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,17,figure_title,"Figure 7. Effects of treatment with MC, GNPs, and hyaluronic acid on the levels of oxidants: (A) DCF; (B) nitrate. The data are presented in mean ± EPM, in which *p < 0.05 vs. excisional wound group (","[326.0, 1444.0, 1124.0, 1521.0]",figure_caption,0.92,"[""figure_title label: Figure 7. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,0,header,"Antioxidants 2022, 11, 2257","[66.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,number,9 of 15,"[1068.0, 110.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,paragraph_title,3.7. Markers of Oxidative Damage and Antioxidants,"[327.0, 191.0, 764.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.7. Markers of Oxidative Damage and Antioxidants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +9,3,text,"Carbonyl levels had a significant decrease in the EW + MC + HA + GNI's group compared to the EW group (Figure 8A). When the sulfhydryl content was evaluated (Figure 8B), we observed that the EW + MC +","[325.0, 223.0, 1124.0, 351.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,figure_title,A,"[333.0, 373.0, 357.0, 398.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,5,chart,,"[337.0, 381.0, 697.0, 606.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,figure_title,B,"[724.0, 373.0, 747.0, 396.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,7,chart,,"[728.0, 385.0, 1097.0, 605.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,8,chart,,"[622.0, 623.0, 857.0, 749.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,9,figure_title,C,"[345.0, 766.0, 367.0, 791.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,10,chart,,"[347.0, 769.0, 699.0, 992.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,11,figure_title,D,"[720.0, 766.0, 743.0, 790.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,12,chart,,"[725.0, 773.0, 1098.0, 991.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,13,figure_title,"Figure 8. Effects of treatment with MIC, GNPs, and hyaluronic acid on the levels of oxidative damage markers and antioxidants: (A) carbonyl; (B) sulfhydryl; (C) SOD; (D) GSH. The data are presented in","[326.0, 1005.0, 1123.0, 1134.0]",figure_caption,0.92,"[""figure_title label: Figure 8. Effects of treatment with MIC, GNPs, and hyaluroni""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,14,text,Antioxidant defense was measured through reduced glutathione and superoxide dismutase levels. SOD levels (Figure 8C) showed a significant decrease in the combined therapy group (EW + MC + HA + GNPs). ,"[324.0, 1152.0, 1123.0, 1255.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,15,paragraph_title,4. Discussion,"[328.0, 1273.0, 458.0, 1296.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +9,16,text,"Wounds are a big problem in terms of social impact, and despite the wide range of therapies that can promote the repair of epithelial lesions, the incidence of wounds is progressively increasing, sinc","[324.0, 1304.0, 1123.0, 1505.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,17,text,"Clinical studies have reported positive wound healing results using electrical stimulation, and for a while, it has been utilized in clinical practice to speed up wound heal-","[326.0, 1506.0, 1127.0, 1556.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,10 of 15,"[1062.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,text,"ing [37,38]. An MC is a specific type of microampere ( $ \mu $A) electrical stimulation that replicates currents generated in the body at the cellular level, and it is known to boost cell physiology a","[324.0, 192.0, 1125.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,text,"In line with what has been exposed, in the present study, a reduction in the levels of pro-inflammatory cytokines (IFN $ \gamma $, TNF $ \alpha $, IL-1 $ \beta $, and IL6) and inflammatory infiltrates","[325.0, 444.0, 1124.0, 568.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,"Individually, each therapy promotes some mechanisms of action in the tissue, and, when combined, they can potentiate their isolated effects. MCs allow the transport of bioactive molecules when combine","[325.0, 569.0, 1126.0, 870.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"Likewise, the use of GNPs can act as an anti-inflammatory agent in the treatment of various models of tissue injury [49] by blocking the activation of nuclear factor kappa β (NF-κB) and combining with","[323.0, 870.0, 1124.0, 1196.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"Only in the group receiving combination treatment was it possible to see an increase in anti-inflammatory cytokines and growth factors, together with a decline in pro-inflammatory cytokines. According","[325.0, 1197.0, 1126.0, 1550.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,0,header,"Antioxidants 2022, 11, 2257","[67.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,1,header,11 of 15,"[1062.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,text,"The effects attributed to HA describe the modulation of pathways that include the suppression of pro-inflammatory cytokines and chemokines [57], in addition to improving membrane stability and favorin","[325.0, 192.0, 1124.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,3,text,"By reducing the formation of reactive oxygen and nitrogen species, reducing oxidative damage, and stimulating the antioxidant system, the group that was subjected to the combination of the suggested t","[325.0, 444.0, 1125.0, 644.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"The capacity of HA to bind to the CD44 receptor, activate pathways involved in the control of cellular redox status, produce intracellular ROS, and chelate $ Fe^{2+} $ and $ Cu^{2+} $ ions—which are","[326.0, 644.0, 1124.0, 795.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,5,text,"Likewise, as an antioxidant agent, GNPs exhibit high catalytic activity for free radical scavenging reactions, affecting the thiol bonds of keap1, causing a conformational change that allows the relea","[325.0, 795.0, 1124.0, 970.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,6,text,"Since excessive levels of ROS in a wound pose a barrier to the healing process, our results show the potential of combined treatments (MC + HA + GNPs) to restore tissue redox homeostasis and to create","[326.0, 971.0, 1123.0, 1045.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,7,text,"Our findings demonstrate that the groups who received MC in conjunction with the topical application of compounds had a reduction in the inflammatory infiltrate when compared to the lesion group, whic","[325.0, 1046.0, 1124.0, 1246.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,8,text,"In line with that previously discussed, when evaluating the wound contraction rate in %, this study shows that all therapeutic approaches can promote the healing process by causing the wound to shrink","[326.0, 1247.0, 1124.0, 1422.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,9,text,"Taken together, these results are in agreement with those found in the study conducted by Mendes et al. (2020), where the benefits of using HA in combination with GNPs were also demonstrated and where","[325.0, 1422.0, 1125.0, 1525.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,number,12 of 15,"[1062.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,paragraph_title,5. Conclusions,"[328.0, 192.0, 471.0, 216.0]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,3,text,"The proposed therapies, when combined, seem to enhance their mechanisms of action, with promising effects in the control of the acute inflammatory response, accelerating the transition to the prolifer","[325.0, 224.0, 1123.0, 298.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,"As a proposal for further studies, it is believed that, with longer analysis periods (between 14 and 21 days), the response of the combined therapy group (EW + MC + HA + GNPs) would have greater reper","[325.0, 299.0, 1124.0, 377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"Author Contributions: C.M.—Conceptualization, Data acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing—original draft, Writing—r","[325.0, 398.0, 1125.0, 633.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,support_like,none,True,True +12,6,text,"Funding: This research was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant number [Call CNPq 06/2019—Research Productivity Scholarships], Fundação de Amparo à Pesq","[326.0, 643.0, 1125.0, 762.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,text,Institutional Review Board Statement: The animal study protocol was approved by the University Ethics Committee (Universidade do Extremo Sul Catarinense—UNESC) with protocol number 16/2020.,"[325.0, 772.0, 1124.0, 820.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,8,text,Informed Consent Statement: Not applicable.,"[328.0, 832.0, 704.0, 854.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,Data Availability Statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.,"[327.0, 867.0, 1122.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,10,text,Conflicts of Interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.,"[326.0, 926.0, 1122.0, 973.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +12,11,paragraph_title,References,"[67.0, 992.0, 175.0, 1015.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +12,12,reference_content,"1. Martinengo, L.; Olsson, M.; Bajpai, R.; Soljak, M.; Upton, Z.; Schmidtchen, A.; Car, J.; Järbrink, K. Prevalence of chronic wounds in the general population: Systematic review and meta-analysis of ","[65.0, 1022.0, 1122.0, 1089.0]",reference_item,0.85,"[""reference content label: 1. 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Hyaluronic acid in inflammation and tissue regeneration. Wounds 2016, 28, 78–88. [PubMed]","[68.0, 241.0, 1121.0, 283.0]",reference_item,0.85,"[""reference content label: 61. Litwiniuk, M.; Krejner, A.; Speyrer, M.S.; Gauto, A.R.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +15,4,reference_content,"62. Trabucchi, E.; Pallotta, S.; Morini, M.; Corsi, F.; Franceschini, R.; Casiraghi, A.; Pravettoni, A.; Foschi, D.; Minghetti, P. Low molecular weight hyaluronic acid prevents oxygen free radical dam","[68.0, 286.0, 1122.0, 352.0]",reference_item,0.85,"[""reference content label: 62. Trabucchi, E.; Pallotta, S.; Morini, M.; Corsi, F.; Fran""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +15,5,reference_content,"63. Cheng, H.; Lai, G.; Fu, L.; Zhang, H.; Yu, A. Enzymatically catalytic deposition of gold nanoparticles by glucose oxidase-functionalized gold nanoprobe for ultrasensitive electrochemical immunoass","[68.0, 355.0, 1122.0, 421.0]",reference_item,0.85,"[""reference content label: 63. Cheng, H.; Lai, G.; Fu, L.; Zhang, H.; Yu, A. Enzymatica""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +15,6,reference_content,"64. Ahn, S.; Singh, P.; Castro-Aceituno, V.; Yesmin Simu, S.; Kim, Y.-J.; Mathiyalagan, R.; Yang, D.-C. Gold nanoparticles synthesized using Panax ginseng leaves suppress inflammatory-mediators produc","[67.0, 425.0, 1122.0, 490.0]",reference_item,0.85,"[""reference content label: 64. Ahn, S.; Singh, P.; Castro-Aceituno, V.; Yesmin Simu, S.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +15,7,reference_content,"65. Pinho, R.A.; Haupenthal, D.P.; Fauser, P.E.; Thirupathi, A.; Silveira, P.C.L. 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The lev", + "found_in_fulltext": true, + "fulltext_offset": 16695 + }, + { + "block_id": "p7:16", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The group treated with only the microcurrent (EW + MC) and the group in which th", + "found_in_fulltext": true, + "fulltext_offset": 16915 + }, + { + "block_id": "p7:17", + "page": 7, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "3.6. 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An MC is a specific type of microampere ( $ \\mu $A) electrical stim", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:3", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In line with what has been exposed, in the present study, a reduction in the lev", + "found_in_fulltext": true, + "fulltext_offset": 20140 + }, + { + "block_id": "p10:4", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Individually, each therapy promotes some mechanisms of action in the tissue, and", + "found_in_fulltext": true, + "fulltext_offset": 20561 + }, + { + "block_id": "p10:5", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Likewise, the use of GNPs can act as an anti-inflammatory agent in the treatment", + "found_in_fulltext": true, + "fulltext_offset": 21565 + }, + { + "block_id": "p10:6", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Only in the group receiving combination treatment was it possible to see an incr", + "found_in_fulltext": true, + "fulltext_offset": 22663 + }, + { + "block_id": "p11:0", + "page": 11, + "role": "noise", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "Antioxidants 2022, 11, 2257", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:1", + "page": 11, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "11 of 15", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:2", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "The effects attributed to HA describe the modulation of pathways that include th", + "found_in_fulltext": true, + "fulltext_offset": 23848 + }, + { + "block_id": "p11:3", + "page": 11, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "By reducing the formation of reactive oxygen and nitrogen species, reducing oxid", + "found_in_fulltext": true, + "fulltext_offset": 24726 + }, + { + "block_id": "p11:4", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "The capacity of HA to bind to the CD44 receptor, activate pathways involved in t", + "found_in_fulltext": true, + "fulltext_offset": 25407 + }, + { + "block_id": "p11:5", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Likewise, as an antioxidant agent, GNPs exhibit high catalytic activity for free", + "found_in_fulltext": true, + "fulltext_offset": 25931 + }, + { + "block_id": "p11:6", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Since excessive levels of ROS in a wound pose a barrier to the healing process, ", + "found_in_fulltext": true, + "fulltext_offset": 26528 + }, + { + "block_id": "p11:7", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Our findings demonstrate that the groups who received MC in conjunction with the", + "found_in_fulltext": true, + "fulltext_offset": 26784 + }, + { + "block_id": "p11:8", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "In line with that previously discussed, when evaluating the wound contraction ra", + "found_in_fulltext": true, + "fulltext_offset": 27481 + }, + { + "block_id": "p11:9", + "page": 11, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Taken together, these results are in agreement with those found in the study con", + "found_in_fulltext": true, + "fulltext_offset": 28100 + }, + { + "block_id": "p12:0", + "page": 12, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Antioxidants 2022, 11, 2257", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:1", + "page": 12, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "12 of 15", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:2", + "page": 12, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "5. Conclusions", + "found_in_fulltext": true, + "fulltext_offset": 28470 + }, + { + "block_id": "p12:3", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The proposed therapies, when combined, seem to enhance their mechanisms of actio", + "found_in_fulltext": true, + "fulltext_offset": 28529 + }, + { + "block_id": "p12:4", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "As a proposal for further studies, it is believed that, with longer analysis per", + "found_in_fulltext": true, + "fulltext_offset": 28775 + }, + { + "block_id": "p12:5", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Author Contributions: C.M.—Conceptualization, Data acquisition, Investigation, M", + "found_in_fulltext": true, + "fulltext_offset": 29060 + }, + { + "block_id": "p12:6", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Funding: This research was funded by Conselho Nacional de Desenvolvimento Cientí", + "found_in_fulltext": true, + "fulltext_offset": 29985 + }, + { + "block_id": "p12:7", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Institutional Review Board Statement: The animal study protocol was approved by ", + "found_in_fulltext": true, + "fulltext_offset": 30378 + }, + { + "block_id": "p12:8", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Informed Consent Statement: Not applicable.", + "found_in_fulltext": true, + "fulltext_offset": 28485 + }, + { + "block_id": "p12:9", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Data Availability Statement: The datasets generated and/or analyzed during the c", + "found_in_fulltext": true, + "fulltext_offset": 30568 + }, + { + "block_id": "p12:11", + "page": 12, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": true, + "fulltext_offset": 30731 + }, + { + "block_id": "p12:12", + "page": 12, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. Martinengo, L.; Olsson, M.; Bajpai, R.; Soljak, M.; Upton, Z.; Schmidtchen, A", + "found_in_fulltext": true, + "fulltext_offset": 30742 + }, + { + "block_id": "p12:13", + "page": 12, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "2. Nussbaum, S.R.; Carter, M.J.; Fife, C.E.; DaVanzo, J.; Haught, R.; Nusgart, M", + "found_in_fulltext": true, + "fulltext_offset": 31017 + }, + { + "block_id": "p12:14", + "page": 12, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "3. Holzer-Geissler, J.C.J.; Schwingenschuh, S.; Zacharias, M.; Einsiedler, J.; K", + "found_in_fulltext": true, + "fulltext_offset": 31306 + }, + { + "block_id": "p12:15", + "page": 12, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "4. Rajendran, S.B.; Challen, K.; Wright, K.L.; Hardy, J.G. 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Zaccaron, R.P.; Barbieri, R.T.; Mendes, C.; Venturini, L.M.; Alves, N.; Maria", + "found_in_fulltext": true, + "fulltext_offset": 32077 + }, + { + "block_id": "p12:19", + "page": 12, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "8. Foulds, I.S.; Barker, A.T. Human skin battery potentials and their possible r", + "found_in_fulltext": true, + "fulltext_offset": 32426 + }, + { + "block_id": "p12:20", + "page": 12, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "9. Nair, H.K.R. 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Electrical stimul", + "found_in_fulltext": true, + "fulltext_offset": 33477 + }, + { + "block_id": "p13:7", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "15. Park, R.J.; Son, H.; Kim, K.; Kim, S.; Oh, T. The Effect of Microcurrent Ele", + "found_in_fulltext": true, + "fulltext_offset": 37581 + }, + { + "block_id": "p13:8", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "16. Clarke Moloney, M.; Lyons, G.M.; Breen, P.; Burke, P.E.; Grace, P.A. Haemody", + "found_in_fulltext": true, + "fulltext_offset": 33716 + }, + { + "block_id": "p13:9", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "17. Sharifi, S.; Hajipour, M.J.; Gould, L.; Mahmoudi, M. Nanomedicine in Healing", + "found_in_fulltext": true, + "fulltext_offset": 37794 + }, + { + "block_id": "p13:10", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "18. Mahmoudi, A.; Kesharwani, P.; Majeed, M.; Teng, Y.; Sahebkar, A. Recent adva", + "found_in_fulltext": true, + "fulltext_offset": 37963 + }, + { + "block_id": "p13:11", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "19. da Rocha, F.R.; Haupenthal, D.P.d.S.; Zaccaron, R.P.; Corrêa, M.E.A.B.; Tram", + "found_in_fulltext": true, + "fulltext_offset": 34037 + }, + { + "block_id": "p13:12", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "20. Akturk, O.; Kismet, K.; Yasti, A.C.; Kuru, S.; Duymus, M.E.; Kaya, F.; Cayde", + "found_in_fulltext": true, + "fulltext_offset": 34359 + }, + { + "block_id": "p13:13", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "21. Mendes, C.; dos Santos Haupenthal, D.P.; Zaccaron, R.P.; de Bem Silveira, G.", + "found_in_fulltext": true, + "fulltext_offset": 34611 + }, + { + "block_id": "p13:14", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "22. Kim, Y.; Lee, Y.-S.; Choe, J.; Lee, H.; Kim, Y.-M.; Jeoung, D. CD44-epiderma", + "found_in_fulltext": true, + "fulltext_offset": 35002 + }, + { + "block_id": "p13:15", + "page": 13, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "23. 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"block_id": "p14:8", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:9", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:10", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:11", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:12", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:13", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:14", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:15", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:16", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:17", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:18", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:19", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:20", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:21", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:22", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:23", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:24", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p14:25", + "page": 14, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:0", + "page": 15, + "role": "noise", + "zone": "", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:1", + "page": 15, + "role": "noise", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:2", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:3", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:4", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:5", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:6", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:7", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:8", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p15:9", + "page": 15, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + } + ] + } +} \ No newline at end of file diff --git a/audit/2GN9LMCW/audit_report.json b/audit/2GN9LMCW/audit_report.json index b68208b9..cbd7eb98 100644 --- a/audit/2GN9LMCW/audit_report.json +++ b/audit/2GN9LMCW/audit_report.json @@ -5,28 +5,28 @@ "focus": [], "artifact_fingerprint": { "result_json_hash": "sha256:01c3565ae504c725cab085c1cfc3222d3020198edd8c4f810f96f6ed860989c9", - "meta_json_hash": "sha256:f57f067e574556ea74a6c5175cd4483210bbf6ccea9e09da873ef17e0a20fd8e", + "meta_json_hash": "sha256:00cc8a559a874d1fbfe87cfa7868d6d607a3167782fca514c8964231365b782e", "blocks_raw_hash": "sha256:443d9b38e8143b17cdbdb48e8b187e7cc471b46b88c5f97170fca13a05c32a33", - "structured_blocks_hash": "sha256:7bf59b0bdfa37da9e14330841b09fd00f746e73e00d98b7a00ecaf6b233de3c8", - "document_structure_hash": "sha256:9646ab9a3718b5975ed83f170b66e2c05354200481748b24543faf2f9d939506", - "figure_inventory_hash": "sha256:403b3cdfb5046c868d22483e308a199a4f2370772848c5e0da678250dac5830d", + "structured_blocks_hash": "sha256:7053a3209ed7bbb779a8ab97d55cf6e4b97e28ecb00737ae1693cb8b5fd4745a", + "document_structure_hash": "sha256:1106e3d28ef6b2fb8ade98b2fcf71db9f2b2a8e2f3d78584a0daf11359866e6c", + "figure_inventory_hash": "sha256:3f70e26b9278f7aaba4e9dbe5aaef0a4a5d4430694a122956e58b1cc515ef292", "table_inventory_hash": "sha256:86ccb48fbfd41da91e87ea2c1ef938513732868efcb5e30b31c36f96d432bba2", - "reader_figures_hash": "sha256:a9b551bd8472f97593fc2d33dd8adc47df38443e5fdd2a67ebe0b84fca311ecc", + "reader_figures_hash": "sha256:584508bdfc3d75b144418b24b58d6e8188220b7d5e5a1b1ba1d841be6f65747c", "resolved_metadata_hash": "sha256:813bcf6e3758e5b5d0cd14731e55b3a942ff76ae96cbc3988dc1eb981337a915", - "fulltext_hash": "sha256:3fc689b379f190eda09eeb6cd9aa704c4f049b9c4c7bb3dddf2144c3c470f8d2", - "block_trace_hash": "sha256:69b2981911a953e0dd746b5699f346b9ecc5379eb3382cc844de8d0a1c433b26", + "fulltext_hash": "sha256:cd0bf41541ee18e90ef6343880f87e92f47f3f575c2fdd5f936197a242bc324c", + "block_trace_hash": "sha256:464c98558c7b7dcab61d14dc36bb959d774a0031e27fb50b8f8a2ccd43e77fb3", "annotated_pages": { - "page_001.png": "sha256:c63b575dc8eb1da2075a5444e84ea0b948c52ccb4020e7005087f20488ca0c3c", - "page_002.png": "sha256:c013778050111eb0cf399b3f3ff731037029a6ef32ca320993217cb2361a2db0", + "page_001.png": "sha256:fdafbc0139f7fdb9faf5fa65b07eff3c998f1e92ffb9f15dbd610f65003b5562", + "page_002.png": "sha256:920eed2ff2830a406c88d264b9885a22522578f4bc3fdc038ac6660c391dfddb", "page_003.png": "sha256:faa28829116d28bc88563c4cffe5b5faf253c1873a9952e86f079e044b09b3ef", - "page_004.png": "sha256:b029807645fd48108ed965f57f87e0c5f9f738a2a106f529f15bffa235ba3bd6", + "page_004.png": "sha256:927e4d9ae890d18abe12f5d1eef8d3d3f7bbf595df564b2beff3ee5b42656cd4", "page_005.png": "sha256:2ba6e8fe72ec796f10c08c567f63b97cb31676b57a4977419cc48c4f9103f784", - "page_006.png": "sha256:3bf2560e7e43b20ad379343e9734448267fde5dc16c487d120c97507164c5f0e", - "page_007.png": "sha256:586ddd93ebb52182abef87ba72965308d36ada3c09b429bb1d55a5ddd7b10656", + "page_006.png": "sha256:9481be9a2874a342d15d109997b9439e31deed301bdac48801519404e78fa851", + "page_007.png": "sha256:1a0cd61d7a3d60496cd042425d2598be900dd803e545a8994485b30db2aae693", "page_008.png": "sha256:d33ed9fe939fea978f520fa3aaba0bc3ebdfe59297835d16f4fae21ef1fe9f1f", - "page_009.png": "sha256:d719f243e40b1d1fe6997198b8ac2b7496a7a9b3febe088b04e3a90a79b72ba5", - "page_010.png": "sha256:0d033ced47ae9dbfc735f1a9cca17d17316663842fd1e2972b8a10e2823ab745", - "page_011.png": "sha256:0c43bdd2504e9944711bc9e2b6c71230a950e7603ea6d381d8875e23caa3ce87", + "page_009.png": "sha256:9eaef6dff663a213a2504295d33ee94c525714d35f7ee1e3f800079455a7146f", + "page_010.png": "sha256:e69090a5afcb34ee95d3dff9f94894ad0e731f7ba7ee1ac653973600485f971a", + "page_011.png": "sha256:c2919b79125d751a5bd4ae3c266416f21e13f3cdfb21cfd9697f5ea86bdd416d", "page_012.png": "sha256:98729e0a040f777dbce76d708f0335a84ef4158bfd43d857275cfd47b0e5a13c", "page_013.png": "sha256:0b6a4e165bff269f0818bf618f65e02bb142ff800dff3b1732d005ac78d597f1", "page_014.png": "sha256:c1ce58f1e9710cdc534a67b044dd998c3eb2a0d149c2876f8f185cea30ba47a3", @@ -36,7 +36,10 @@ "artifact_freshness": { "missing": [], "mismatches": [ - "document_structure older than blocks_structured" + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" ], "annotated_pages_rendered": [ "page_001.png", @@ -62,7 +65,6 @@ 6, 7, 9, - 10, 11 ], "reviewed_blocks": [ @@ -126,17 +128,6 @@ "p9:9", "p9:10", "p9:11", - "p10:0", - "p10:1", - "p10:2", - "p10:3", - "p10:4", - "p10:5", - "p10:6", - "p10:7", - "p10:8", - "p10:9", - "p10:10", "p11:0", "p11:1", "p11:2", @@ -441,6 +432,18 @@ "artifact": "reference_span_audit.json" } }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_011.png", + "artifact": "page_risk_summary.json" + } + }, { "category": "render_mapping_error", "severity": "minor", @@ -448,23 +451,23 @@ "p1:2", "p1:3", "p1:4", + "p1:5", + "p1:13", "p1:20", "p2:1", "p2:5", "p2:6", "p3:8", "p3:9", - "p4:2", "p4:7", "p4:8", "p5:6", "p5:7", - "p6:2", "p6:3", "p6:7", "p6:8", - "p7:2", - "p7:7" + "p7:7", + "p7:8" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/2GN9LMCW/audit_report.md b/audit/2GN9LMCW/audit_report.md index 6da03052..ce8b8cd0 100644 --- a/audit/2GN9LMCW/audit_report.md +++ b/audit/2GN9LMCW/audit_report.md @@ -2,8 +2,8 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [1, 4, 6, 7, 9, 10, 11] -- Reviewed blocks: 93 +- Reviewed pages: [1, 4, 6, 7, 9, 11] +- Reviewed blocks: 82 ## Findings @@ -27,6 +27,7 @@ - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output ## Disposition Guidance diff --git a/audit/2GN9LMCW/audit_scope.json b/audit/2GN9LMCW/audit_scope.json index 299e9651..2b76187a 100644 --- a/audit/2GN9LMCW/audit_scope.json +++ b/audit/2GN9LMCW/audit_scope.json @@ -6,7 +6,6 @@ 6, 7, 9, - 10, 11 ], "required_block_ids": [ @@ -32,12 +31,9 @@ "p1:19", "p1:20", "p4:1", - "p4:2", "p4:6", "p6:1", - "p6:2", "p7:1", - "p7:2", "p9:2", "p9:3", "p9:4", @@ -45,23 +41,7 @@ "p9:6", "p9:7", "p9:8", - "p9:9", - "p10:6", - "p10:7", - "p10:8", - "p11:1", - "p11:2", - "p11:3", - "p11:4", - "p11:5", - "p11:6", - "p11:7", - "p11:8", - "p11:9", - "p11:10", - "p11:11", "p11:12", - "p11:13", "p11:14", "p11:15", "p11:16", @@ -403,21 +383,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p4:2", - "page": 4, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p4:6", "page": 4, @@ -448,21 +413,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p6:2", - "page": 6, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:1", "page": 7, @@ -478,21 +428,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p7:2", - "page": 7, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p9:2", "page": 9, @@ -598,231 +533,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p9:9", - "page": 9, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p10:6", - "page": 10, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p10:7", - "page": 10, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p10:8", - "page": 10, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:1", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:2", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:3", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:4", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:5", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:6", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:7", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:8", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:9", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:10", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:11", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:12", "page": 11, @@ -838,21 +548,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:13", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:14", "page": 11, @@ -983,32 +678,27 @@ { "page": 4, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 2 }, { "page": 6, "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 7, "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 9, "must_review_page": true, - "required_block_count": 8 - }, - { - "page": 10, - "must_review_page": true, - "required_block_count": 3 + "required_block_count": 7 }, { "page": 11, "must_review_page": true, - "required_block_count": 21 + "required_block_count": 9 } ] } \ No newline at end of file diff --git a/audit/2GN9LMCW/block_coverage_summary.json b/audit/2GN9LMCW/block_coverage_summary.json index 91fe78d9..984ab737 100644 --- a/audit/2GN9LMCW/block_coverage_summary.json +++ b/audit/2GN9LMCW/block_coverage_summary.json @@ -140,7 +140,7 @@ "block_id": "p1:5", "page": 1, "raw_label": "text", - "role": "frontmatter_noise", + "role": "frontmatter_support", "zone": "frontmatter_main_zone", "bbox": [ 357.0, @@ -300,7 +300,7 @@ "block_id": "p1:13", "page": 1, "raw_label": "text", - "role": "frontmatter_noise", + "role": "frontmatter_support", "zone": "frontmatter_main_zone", "bbox": [ 64.0, @@ -480,7 +480,7 @@ "block_id": "p2:1", "page": 2, "raw_label": "text", - "role": "frontmatter_support", + "role": "unknown_structural", "zone": "body_zone", "bbox": [ 361.0, @@ -561,7 +561,7 @@ "page": 2, "raw_label": "footer", "role": "noise", - "zone": "", + "zone": "frontmatter_main_zone", "bbox": [ 63.0, 1501.0, @@ -820,7 +820,7 @@ "block_id": "p4:1", "page": 4, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 364.0, @@ -840,7 +840,7 @@ "block_id": "p4:2", "page": 4, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 373.0, @@ -1160,7 +1160,7 @@ "block_id": "p6:1", "page": 6, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 366.0, @@ -1180,7 +1180,7 @@ "block_id": "p6:2", "page": 6, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 373.0, @@ -1340,7 +1340,7 @@ "block_id": "p7:1", "page": 7, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 372.0, @@ -1360,7 +1360,7 @@ "block_id": "p7:2", "page": 7, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 373.0, @@ -1720,7 +1720,7 @@ "block_id": "p9:2", "page": 9, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 429.0, @@ -1740,7 +1740,7 @@ "block_id": "p9:3", "page": 9, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 772.0, @@ -1760,7 +1760,7 @@ "block_id": "p9:4", "page": 9, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 363.0, @@ -1780,7 +1780,7 @@ "block_id": "p9:5", "page": 9, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 766.0, @@ -1800,7 +1800,7 @@ "block_id": "p9:6", "page": 9, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 428.0, @@ -1820,7 +1820,7 @@ "block_id": "p9:7", "page": 9, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 765.0, @@ -1860,7 +1860,7 @@ "block_id": "p9:9", "page": 9, "raw_label": "text", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 373.0, @@ -2040,7 +2040,7 @@ "block_id": "p10:6", "page": 10, "raw_label": "paragraph_title", - "role": "backmatter_boundary_candidate", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 371.0, @@ -2060,7 +2060,7 @@ "block_id": "p10:7", "page": 10, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "bbox": [ 364.0, @@ -2080,7 +2080,7 @@ "block_id": "p10:8", "page": 10, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 362.0, @@ -2160,7 +2160,7 @@ "block_id": "p11:1", "page": 11, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 364.0, @@ -2180,7 +2180,7 @@ "block_id": "p11:2", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 363.0, @@ -2200,7 +2200,7 @@ "block_id": "p11:3", "page": 11, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 364.0, @@ -2220,7 +2220,7 @@ "block_id": "p11:4", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 363.0, @@ -2240,7 +2240,7 @@ "block_id": "p11:5", "page": 11, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 365.0, @@ -2260,7 +2260,7 @@ "block_id": "p11:6", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 364.0, @@ -2280,7 +2280,7 @@ "block_id": "p11:7", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 364.0, @@ -2300,7 +2300,7 @@ "block_id": "p11:8", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 365.0, @@ -2320,7 +2320,7 @@ "block_id": "p11:9", "page": 11, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 365.0, @@ -2340,7 +2340,7 @@ "block_id": "p11:10", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 364.0, @@ -2360,7 +2360,7 @@ "block_id": "p11:11", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 388.0, @@ -2400,7 +2400,7 @@ "block_id": "p11:13", "page": 11, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 363.0, diff --git a/audit/2GN9LMCW/block_review.jsonl b/audit/2GN9LMCW/block_review.jsonl index 47ea1380..e79b4fe5 100644 --- a/audit/2GN9LMCW/block_review.jsonl +++ b/audit/2GN9LMCW/block_review.jsonl @@ -24,14 +24,14 @@ {"block_id": "p4:6", "page": 4, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_004.png", "method": "visual+bbox"}, "short_reason": "Body paragraph under Cell viability and activity. Pipeline: body_paragraph. Correct.", "_pipeline_verified": true, "_current_role": "body_paragraph"} {"block_id": "p6:1", "page": 6, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image (calcium deposition). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p6:2", "page": 6, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Figure 2 caption. Pipeline: figure_caption_candidate. Finding: should be figure_caption (confirmed caption, not a candidate). Zone correct (display_zone).", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} -{"block_id": "p7:1", "page": 7, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 image (cell viability bar chart). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p7:1", "page": 7, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 image (cell viability bar chart). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p7:2", "page": 7, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 caption. Pipeline: figure_caption_candidate. Finding: should be figure_caption (confirmed caption, not a candidate). Zone correct (display_zone).", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} -{"block_id": "p9:2", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel A (Runx2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p9:3", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel D (Runx2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p9:4", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel B (Osteopontin BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p9:5", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel E (Osteopontin AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p9:6", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel C (Col1A2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p9:7", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel F (Col1A2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p9:2", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel A (Runx2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p9:3", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel D (Runx2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p9:4", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel B (Osteopontin BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p9:5", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel E (Osteopontin AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p9:6", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel C (Col1A2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p9:7", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel F (Col1A2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p9:8", "page": 9, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "X-axis label 'Days post culture...' for Figure 4. Pipeline: figure_caption_candidate in body_zone. Finding: wrong role (should be figure_inner_text, not caption candidate) and wrong zone (should be display_zone not body_zone).", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "body_zone"} {"block_id": "p9:9", "page": 9, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 caption. Pipeline: figure_caption_candidate. Finding: should be figure_caption (confirmed caption, not a candidate). Zone correct (display_zone).", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p10:6", "page": 10, "review_status": "reviewed", "truth_role": "backmatter_heading", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_010.png", "method": "visual+bbox"}, "short_reason": "ADDITIONAL INFORMATION AND DECLARATIONS heading. Pipeline: backmatter_boundary_candidate. Finding: should be backmatter_heading (confirmed section heading for backmatter). Zone correct (body_zone).", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone"} diff --git a/audit/2GN9LMCW/block_trace.csv b/audit/2GN9LMCW/block_trace.csv index fd07fcae..bf6533d0 100644 --- a/audit/2GN9LMCW/block_trace.csv +++ b/audit/2GN9LMCW/block_trace.csv @@ -1,10 +1,10 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default 1,0,header_image,,"[67.0, 127.0, 262.0, 313.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True -1,1,doc_title,In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells,"[362.0, 124.0, 1123.0, 264.0]",paper_title,0.6,"[""page-1 frontmatter title guard: In vitro effect of direct current electrical stimulation on ""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,1,doc_title,In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells,"[362.0, 124.0, 1123.0, 264.0]",paper_title,0.8,"[""page-1 zone title_zone: In vitro effect of direct current electrical stimulation on ""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True 1,2,text,"Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishnu Thottakkattumana Parameswaran $ ^{1} $ and John Howard Barker $ ^{1} $","[361.0, 293.0, 1159.0, 350.0]",authors,0.8,"[""page-1 zone author_zone: Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishn""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,3,text," $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Experimental Orthopedics and Trauma Surgery, Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany","[355.0, 361.0, 1119.0, 404.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Exp""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True 1,4,text," $ ^{2} $School of Materials, Faculty of Engineering and Physical Sciences, University of Manchester, Manchester, United Kingdom","[355.0, 406.0, 1126.0, 447.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $School of Materials, Faculty of Engineering and Phys""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True -1,5,text,These authors contributed equally to this work.,"[357.0, 449.0, 712.0, 472.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: These authors contributed equally to this work.""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,5,text,These authors contributed equally to this work.,"[357.0, 449.0, 712.0, 472.0]",frontmatter_support,0.78,"[""first-surviving-page support text: These authors contributed equally to this work.""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True 1,6,paragraph_title,ABSTRACT,"[388.0, 510.0, 548.0, 539.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True 1,7,text,"Submitted 12 July 2016 Accepted 22 November 2016 @@ -18,7 +18,7 @@ Creative Commons CC-BY 4.0","[64.0, 1346.0, 316.0, 1391.0]",frontmatter_noise,0. 1,13,text,"Corresponding author Sahba Mobini, sahba.mobini@manchester.ac.uk, -sahba.mobini@gmail.com","[64.0, 1023.0, 315.0, 1111.0]",frontmatter_noise,0.85,"[""contact/email: Corresponding author\nSahba Mobini,\nsahba.mobini@manchester.a""]",frontmatter_noise,0.85,frontmatter_main_zone,support_like,none,False,False +sahba.mobini@gmail.com","[64.0, 1023.0, 315.0, 1111.0]",frontmatter_support,0.78,"[""first-surviving-page support text: Corresponding author\nSahba Mobini,\nsahba.mobini@manchester.a""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True 1,14,text,DOI 10.7717/peerj.2821,"[66.0, 1247.0, 249.0, 1271.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False 1,15,text,"Academic editor Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic editor\nJalees Rehman""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False @@ -28,11 +28,11 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1 1,19,text,"Large segment bone defects, caused by open fractures, non-unions, infections and tumor resection are a major challenge in trauma and orthopedic surgery. Complications associated with current treatment","[361.0, 1245.0, 1159.0, 1423.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,20,footer,"How to cite this article Mobini et al. (2017), In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells. PeerJ 5:e2821; DOI 10.7717/peerj.2821","[362.0, 1497.0, 1143.0, 1534.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 2,0,header,PeerJ,"[61.0, 71.0, 156.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False -2,1,text,"hold great potential for achieving optimal bone healing while eliminating the associated drawbacks of conventional treatments (Petite et al., 2000).","[361.0, 167.0, 1149.0, 223.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,1,text,"hold great potential for achieving optimal bone healing while eliminating the associated drawbacks of conventional treatments (Petite et al., 2000).","[361.0, 167.0, 1149.0, 223.0]",unknown_structural,0.8,"[""page-1 zone author_zone: hold great potential for achieving optimal bone healing whil""]",authors,0.8,body_zone,body_like,none,False,True 2,2,text,Mesenchymal stem cells (MSCs) have been shown to be an attractive cell source for clinical bone tissue engineering applications. MSCs possess a great capacity for self-renewal and multi-lineage differ,"[361.0, 226.0, 1162.0, 758.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,3,text,"Electrical stimulation (ES) has been shown to be effective in nerve and cardiac tissue engineering applications, primarily due to the electric nature of these tissues (Ghasemi-Mobarakeh et al., 2011; ","[362.0, 760.0, 1159.0, 1379.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,4,text,"Recently, various different types of physical stimuli such as static magnetic fields, cyclic strain, low frequency vibration, and electric signals have been used to improve","[362.0, 1382.0, 1133.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,5,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +2,5,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_pattern,False,False 2,6,number,2/15,"[1117.0, 1503.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,0,header,PeerJ,"[61.0, 71.0, 156.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False 3,1,text,"both the proliferative and the differentiation potential of stem cells. Specifically, ES has been shown to influence cell proliferation and differentiation in tissue engineering applications (Balint, ","[361.0, 167.0, 1163.0, 670.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -45,8 +45,8 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1 3,8,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False 3,9,number,3/15,"[1116.0, 1502.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 4,0,header,PeerJ,"[61.0, 71.0, 156.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False -4,1,image,,"[364.0, 176.0, 1154.0, 564.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -4,2,figure_title,"Figure 1 Setup for delivering direct current electrical stimulation to the cells. L-shaped platinum electrodes, 22 mm apart, secured to the lid of a 6-well cell culture plate and connected to a standa","[373.0, 585.0, 1147.0, 675.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 1 Setup for delivering direct current electrical stim""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +4,1,image,,"[364.0, 176.0, 1154.0, 564.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,2,figure_title,"Figure 1 Setup for delivering direct current electrical stimulation to the cells. L-shaped platinum electrodes, 22 mm apart, secured to the lid of a 6-well cell culture plate and connected to a standa","[373.0, 585.0, 1147.0, 675.0]",figure_caption,0.92,"[""figure_title label: Figure 1 Setup for delivering direct current electrical stim""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 4,3,paragraph_title,Electrical stimulation of cells,"[363.0, 702.0, 703.0, 728.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrical stimulation of cells""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 4,4,text,"Electrical stimulation was applied by means of a purpose built DC ES cell culture chamber (Mobini, Leppik & Barker, 2016). Briefly, the chamber consists of L-shaped platinum electrodes, separated by a","[360.0, 733.0, 1161.0, 1033.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,5,paragraph_title,Cell viability and activity,"[363.0, 1048.0, 652.0, 1076.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity""]",subsection_heading,0.6,body_zone,heading_like,none,True,True @@ -62,8 +62,8 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1 5,6,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False 5,7,number,5/15,"[1117.0, 1502.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,0,header,PeerJ,"[61.0, 71.0, 156.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False -6,1,image,,"[366.0, 170.0, 1153.0, 859.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -6,2,figure_title,Figure 2 Calcium deposition. Calcium deposition stained using Alizarin Red S for; (A) BM-MSCs and AT-MSCs exposed to no electrical stimulation (controls) at days 7 and 14; (B) BM-MSCs and AT-MSCs expo,"[373.0, 882.0, 1149.0, 1019.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 2 Calcium deposition. Calcium deposition stained usin""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +6,1,image,,"[366.0, 170.0, 1153.0, 859.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +6,2,figure_title,Figure 2 Calcium deposition. Calcium deposition stained using Alizarin Red S for; (A) BM-MSCs and AT-MSCs exposed to no electrical stimulation (controls) at days 7 and 14; (B) BM-MSCs and AT-MSCs expo,"[373.0, 882.0, 1149.0, 1019.0]",figure_caption,0.92,"[""figure_title label: Figure 2 Calcium deposition. Calcium deposition stained usin""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 6,3,text,in growth medium at day 0). Standard deviation (SD) was calculated with the $ \Delta C_{q} $ value of technical triplicates.,"[362.0, 1049.0, 1154.0, 1107.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,4,paragraph_title,RESULTS Electrical stimulation optimization,"[363.0, 1135.0, 760.0, 1204.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: RESULTS Electrical stimulation optimization""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 6,5,footer,,"[363.0, 1175.0, 760.0, 1204.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False @@ -71,8 +71,8 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1 6,7,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64.0, 1501.0, 495.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False 6,8,number,6/15,"[1117.0, 1502.0, 1158.0, 1523.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 7,0,header,PeerJ,"[61.0, 70.0, 156.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False -7,1,chart,,"[372.0, 171.0, 1043.0, 729.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True -7,2,figure_title,"Figure 3 Cell viability. Measured by MTT assay, compared between electrically stimulated and non-stimulated controls. No significant difference in cell viability was detected between ES and non-stimul","[373.0, 749.0, 1147.0, 840.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 3 Cell viability. Measured by MTT assay, compared bet""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +7,1,chart,,"[372.0, 171.0, 1043.0, 729.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,2,figure_title,"Figure 3 Cell viability. Measured by MTT assay, compared between electrically stimulated and non-stimulated controls. No significant difference in cell viability was detected between ES and non-stimul","[373.0, 749.0, 1147.0, 840.0]",figure_caption,0.92,"[""figure_title label: Figure 3 Cell viability. Measured by MTT assay, compared bet""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 7,3,paragraph_title,Cell viability and activity,"[363.0, 870.0, 651.0, 899.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 7,4,text,"MTT assay was performed to compare viability and activity of electrically stimulated cells vs. non-stimulated controls. None of the cells exposed to 10, 50 and 100 mV/mm showed signs of toxicity. Figu","[360.0, 903.0, 1155.0, 1170.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,5,paragraph_title,Osteogenic differentiation,"[363.0, 1187.0, 669.0, 1215.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Osteogenic differentiation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True @@ -91,43 +91,43 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1 9,0,header,PeerJ,"[61.0, 71.0, 155.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False 9,1,vision_footnote,"No Electrical Stimulation Electrical Stimulation 100 mV/mm","[449.0, 168.0, 738.0, 219.0]",footnote,0.7,"[""vision_footnote label: No Electrical Stimulation\nElectrical Stimulation 100 mV/mm""]",footnote,0.7,body_zone,unknown_like,none,True,True -9,2,chart,,"[429.0, 237.0, 733.0, 485.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -9,3,chart,,"[772.0, 238.0, 1071.0, 484.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -9,4,chart,,"[363.0, 504.0, 742.0, 757.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True -9,5,chart,,"[766.0, 503.0, 1075.0, 750.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -9,6,chart,,"[428.0, 774.0, 729.0, 1016.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -9,7,chart,,"[765.0, 768.0, 1075.0, 1013.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,2,chart,,"[429.0, 237.0, 733.0, 485.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,3,chart,,"[772.0, 238.0, 1071.0, 484.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,4,chart,,"[363.0, 504.0, 742.0, 757.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +9,5,chart,,"[766.0, 503.0, 1075.0, 750.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,chart,,"[428.0, 774.0, 729.0, 1016.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,7,chart,,"[765.0, 768.0, 1075.0, 1013.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 9,8,figure_title,Days post culture in osteogenic differentiation supplemented medium,"[374.0, 1046.0, 1143.0, 1077.0]",figure_caption_candidate,0.85,"[""figure_title label: Days post culture in osteogenic differentiation supplemented""]",figure_caption,0.85,body_zone,legend_like,none,False,False -9,9,text,"Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2, (B) Osteopontin, (C) Collagen Type1 (Col1A2) in BM-MSCs; (D) Runx2, (E) Osteopontin and (F) Col1A2 in AT-MSCs, in both ","[373.0, 1101.0, 1143.0, 1258.0]",figure_caption_candidate,0.9,"[""figure prefix matched: Figure 4 RT-qPCR results. Temporal changes in messenger RNA "", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,False,False +9,9,text,"Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2, (B) Osteopontin, (C) Collagen Type1 (Col1A2) in BM-MSCs; (D) Runx2, (E) Osteopontin and (F) Col1A2 in AT-MSCs, in both ","[373.0, 1101.0, 1143.0, 1258.0]",figure_caption,0.9,"[""figure prefix matched: Figure 4 RT-qPCR results. Temporal changes in messenger RNA "", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True 9,10,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64.0, 1501.0, 495.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False 9,11,number,9/15,"[1117.0, 1502.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 10,0,header,PeerJ,"[61.0, 71.0, 156.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False -10,1,text,"the known differences in osteogenic differentiation capacity between BM- and AT-derived MSC. Namely, studies that suggest AT-MSCs have less osteogenic potential than BM-MSCs (Ratanavaraporn et al., 20","[361.0, 167.0, 1162.0, 313.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,2,text,"Our results indicate that in control groups (osteogenic supplemented medium, without electrical stimulation), both in BM- and AT-MSCs, only a slight difference exists in temporal expression patterns o","[362.0, 317.0, 1161.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,3,text,"Runx2 is known as a master osteogenic transcription factor. Runx2 activates and regulates osteogenesis as the targeted gene of many signaling pathways, including transforming growth factor-beta 1 (TGF","[361.0, 465.0, 1161.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,1,text,"the known differences in osteogenic differentiation capacity between BM- and AT-derived MSC. Namely, studies that suggest AT-MSCs have less osteogenic potential than BM-MSCs (Ratanavaraporn et al., 20","[361.0, 167.0, 1162.0, 313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,2,text,"Our results indicate that in control groups (osteogenic supplemented medium, without electrical stimulation), both in BM- and AT-MSCs, only a slight difference exists in temporal expression patterns o","[362.0, 317.0, 1161.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,text,"Runx2 is known as a master osteogenic transcription factor. Runx2 activates and regulates osteogenesis as the targeted gene of many signaling pathways, including transforming growth factor-beta 1 (TGF","[361.0, 465.0, 1161.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,4,paragraph_title,CONCLUSIONS,"[364.0, 939.0, 578.0, 970.0]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSIONS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True -10,5,text,"We have demonstrated that DC ES promotes Runx2, Osteopontin and Col1A2 expression in BM-MSCs already at 7 days. Our results indicate that DC ES effects osteogenic gene expression, in both BM- and AT-M","[361.0, 983.0, 1158.0, 1192.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,6,paragraph_title,ADDITIONAL INFORMATION AND DECLARATIONS,"[371.0, 1224.0, 1050.0, 1256.0]",backmatter_boundary_candidate,0.5,"[""backmatter boundary candidate: ADDITIONAL INFORMATION AND DECLARATIONS""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True -10,7,paragraph_title,Funding,"[364.0, 1287.0, 466.0, 1316.0]",backmatter_heading,0.8,"[""backmatter heading on page 10: Funding""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -10,8,text,"The work described herein was supported in part by a grant from the AO Foundation (#S-14-03H) and from the Friedrichsheim Foundation (Stiftung Friedrichsheim) in Frankfurt/Main, Germany. The funders h","[362.0, 1319.0, 1149.0, 1439.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"We have demonstrated that DC ES promotes Runx2, Osteopontin and Col1A2 expression in BM-MSCs already at 7 days. Our results indicate that DC ES effects osteogenic gene expression, in both BM- and AT-M","[361.0, 983.0, 1158.0, 1192.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,paragraph_title,ADDITIONAL INFORMATION AND DECLARATIONS,"[371.0, 1224.0, 1050.0, 1256.0]",body_paragraph,0.5,"[""backmatter boundary candidate: ADDITIONAL INFORMATION AND DECLARATIONS""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True +10,7,paragraph_title,Funding,"[364.0, 1287.0, 466.0, 1316.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Funding""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,8,text,"The work described herein was supported in part by a grant from the AO Foundation (#S-14-03H) and from the Friedrichsheim Foundation (Stiftung Friedrichsheim) in Frankfurt/Main, Germany. The funders h","[362.0, 1319.0, 1149.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,9,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False 10,10,number,10/15,"[1108.0, 1502.0, 1158.0, 1523.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 11,0,header,PeerJ,"[62.0, 72.0, 155.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False -11,1,paragraph_title,Grant Disclosures,"[364.0, 164.0, 578.0, 191.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Grant Disclosures""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True +11,1,paragraph_title,Grant Disclosures,"[364.0, 164.0, 578.0, 191.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Grant Disclosures""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 11,2,text,"The following grant information was disclosed by the authors: AO Foundation: #S-14-03H. -Friedrichsheim Foundation.","[363.0, 197.0, 917.0, 280.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,3,paragraph_title,Competing Interests,"[364.0, 303.0, 604.0, 330.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Competing Interests""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -11,4,text,The authors declare there are no competing interests.,"[363.0, 336.0, 838.0, 361.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,5,paragraph_title,Author Contributions,"[365.0, 380.0, 614.0, 406.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Author Contributions""]",backmatter_heading_candidate,0.8,body_zone,support_like,none,True,True -11,6,text,"● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.","[364.0, 413.0, 1158.0, 497.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,7,text,"- Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figures and/or tables.","[364.0, 502.0, 1157.0, 556.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,8,text,"● John Howard Barker contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.","[365.0, 563.0, 1138.0, 618.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,9,paragraph_title,Data Availability,"[365.0, 637.0, 556.0, 665.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Data Availability""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -11,10,text,The following information was supplied regarding data availability:,"[364.0, 670.0, 961.0, 696.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,11,text,The raw data has been supplied as Supplementary Files.,"[388.0, 701.0, 884.0, 726.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,12,paragraph_title,Supplemental Information,"[364.0, 745.0, 667.0, 774.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Supplemental Information""]",backmatter_heading_candidate,0.8,body_zone,heading_like,none,True,True -11,13,text,Supplemental information for this article can be found online at http://dx.doi.org/10.7717/peerj.2821#supplemental-information.,"[363.0, 778.0, 1158.0, 835.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +Friedrichsheim Foundation.","[363.0, 197.0, 917.0, 280.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,3,paragraph_title,Competing Interests,"[364.0, 303.0, 604.0, 330.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing Interests""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,4,text,The authors declare there are no competing interests.,"[363.0, 336.0, 838.0, 361.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,paragraph_title,Author Contributions,"[365.0, 380.0, 614.0, 406.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author Contributions""]",subsection_heading,0.6,body_zone,support_like,none,True,True +11,6,text,"● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.","[364.0, 413.0, 1158.0, 497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"- Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figures and/or tables.","[364.0, 502.0, 1157.0, 556.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,8,text,"● John Howard Barker contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.","[365.0, 563.0, 1138.0, 618.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,paragraph_title,Data Availability,"[365.0, 637.0, 556.0, 665.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data Availability""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,10,text,The following information was supplied regarding data availability:,"[364.0, 670.0, 961.0, 696.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,text,The raw data has been supplied as Supplementary Files.,"[388.0, 701.0, 884.0, 726.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,12,paragraph_title,Supplemental Information,"[364.0, 745.0, 667.0, 774.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supplemental Information""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +11,13,text,Supplemental information for this article can be found online at http://dx.doi.org/10.7717/peerj.2821#supplemental-information.,"[363.0, 778.0, 1158.0, 835.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,14,paragraph_title,REFERENCES,"[365.0, 874.0, 562.0, 904.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True 11,15,reference_content,"Amini AR, Laurencin CT, Nukavarapu SP. 2012. Bone tissue engineering: recent advances and challenges. Critical Reviews in Biomedical Engineering 40:363–408. DOI 10.1615/CritRevBiomedEng.v40.i5.10.","[369.0, 925.0, 1106.0, 1008.0]",reference_item,0.85,"[""reference content label: Amini AR, Laurencin CT, Nukavarapu SP. 2012. Bone tissue eng""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True 11,16,reference_content,"Balint R, Cassidy NJ, Cartmell SH. 2013. Electrical stimulation: a novel tool for tissue engineering. Tissue Engineering Part B: Reviews 19:48–57. diff --git a/audit/2GN9LMCW/changed_blocks_after_fallback.json b/audit/2GN9LMCW/changed_blocks_after_fallback.json index 4f709468..4c8a692e 100644 --- a/audit/2GN9LMCW/changed_blocks_after_fallback.json +++ b/audit/2GN9LMCW/changed_blocks_after_fallback.json @@ -241,7 +241,7 @@ { "block_id": "p7:1", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -259,7 +259,7 @@ { "block_id": "p9:2", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -268,7 +268,7 @@ { "block_id": "p9:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -277,7 +277,7 @@ { "block_id": "p9:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -286,7 +286,7 @@ { "block_id": "p9:5", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -295,7 +295,7 @@ { "block_id": "p9:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -304,7 +304,7 @@ { "block_id": "p9:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, diff --git a/audit/2GN9LMCW/coverage_check.json b/audit/2GN9LMCW/coverage_check.json index 42f524bf..ebc169f6 100644 --- a/audit/2GN9LMCW/coverage_check.json +++ b/audit/2GN9LMCW/coverage_check.json @@ -2,30 +2,15 @@ "paper_key": "2GN9LMCW", "mode": "high-risk", "required_block_ids": [ - "p10:6", - "p10:7", - "p10:8", - "p11:1", - "p11:10", - "p11:11", "p11:12", - "p11:13", "p11:14", "p11:15", "p11:16", "p11:17", "p11:18", "p11:19", - "p11:2", "p11:20", "p11:21", - "p11:3", - "p11:4", - "p11:5", - "p11:6", - "p11:7", - "p11:8", - "p11:9", "p1:0", "p1:1", "p1:10", @@ -48,20 +33,16 @@ "p1:8", "p1:9", "p4:1", - "p4:2", "p4:6", "p6:1", - "p6:2", "p7:1", - "p7:2", "p9:2", "p9:3", "p9:4", "p9:5", "p9:6", "p9:7", - "p9:8", - "p9:9" + "p9:8" ], "reviewed_block_ids": [ "p10:6", diff --git a/audit/2GN9LMCW/fulltext_block_mapping_summary.json b/audit/2GN9LMCW/fulltext_block_mapping_summary.json index 1970323a..5e980c0a 100644 --- a/audit/2GN9LMCW/fulltext_block_mapping_summary.json +++ b/audit/2GN9LMCW/fulltext_block_mapping_summary.json @@ -1,7 +1,7 @@ { - "mappable_block_count": 156, + "mappable_block_count": 154, "found_count": 117, - "missing_count": 39, + "missing_count": 37, "rows": [ { "block_id": "p1:1", @@ -43,6 +43,26 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p1:5", + "page": 1, + "role": "frontmatter_support", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "These authors contributed equally to this work.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:13", + "page": 1, + "role": "frontmatter_support", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "Corresponding author Sahba Mobini, sahba.mobini@manchester.ac.uk, sahba.mobini@g", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p1:18", "page": 1, @@ -86,9 +106,9 @@ { "block_id": "p2:1", "page": 2, - "role": "frontmatter_support", + "role": "unknown_structural", "zone": "body_zone", - "render_default": true, + "render_default": false, "snippet": "hold great potential for achieving optimal bone healing while eliminating the as", "found_in_fulltext": false, "fulltext_offset": -1 @@ -127,7 +147,7 @@ "block_id": "p2:5", "page": 2, "role": "noise", - "zone": "", + "zone": "frontmatter_main_zone", "render_default": false, "snippet": "Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821", "found_in_fulltext": false, @@ -243,16 +263,6 @@ "found_in_fulltext": true, "fulltext_offset": 233 }, - { - "block_id": "p4:2", - "page": 4, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Figure 1 Setup for delivering direct current electrical stimulation to the cells", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p4:3", "page": 4, @@ -403,16 +413,6 @@ "found_in_fulltext": true, "fulltext_offset": 233 }, - { - "block_id": "p6:2", - "page": 6, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Figure 2 Calcium deposition. Calcium deposition stained using Alizarin Red S for", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p6:3", "page": 6, @@ -473,16 +473,6 @@ "found_in_fulltext": true, "fulltext_offset": 233 }, - { - "block_id": "p7:2", - "page": 7, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Figure 3 Cell viability. Measured by MTT assay, compared between electrically st", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p7:3", "page": 7, @@ -663,16 +653,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p9:9", - "page": 9, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2,", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p9:10", "page": 9, @@ -756,7 +736,7 @@ { "block_id": "p10:6", "page": 10, - "role": "backmatter_boundary_candidate", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "ADDITIONAL INFORMATION AND DECLARATIONS", @@ -766,7 +746,7 @@ { "block_id": "p10:7", "page": 10, - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Funding", @@ -776,7 +756,7 @@ { "block_id": "p10:8", "page": 10, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "The work described herein was supported in part by a grant from the AO Foundatio", @@ -816,17 +796,17 @@ { "block_id": "p11:1", "page": 11, - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Grant Disclosures", "found_in_fulltext": true, - "fulltext_offset": 22985 + "fulltext_offset": 22987 }, { "block_id": "p11:2", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "The following grant information was disclosed by the authors: AO Foundation: #S-", @@ -836,7 +816,7 @@ { "block_id": "p11:3", "page": 11, - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Competing Interests", @@ -846,7 +826,7 @@ { "block_id": "p11:4", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "The authors declare there are no competing interests.", @@ -856,7 +836,7 @@ { "block_id": "p11:5", "page": 11, - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Author Contributions", @@ -866,7 +846,7 @@ { "block_id": "p11:6", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, perfo", @@ -876,7 +856,7 @@ { "block_id": "p11:7", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "- Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figur", @@ -886,7 +866,7 @@ { "block_id": "p11:8", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "● John Howard Barker contributed reagents/materials/analysis tools, wrote the pa", @@ -896,7 +876,7 @@ { "block_id": "p11:9", "page": 11, - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Data Availability", @@ -906,7 +886,7 @@ { "block_id": "p11:10", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "The following information was supplied regarding data availability:", @@ -916,7 +896,7 @@ { "block_id": "p11:11", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "The raw data has been supplied as Supplementary Files.", @@ -936,7 +916,7 @@ { "block_id": "p11:13", "page": 11, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "Supplemental information for this article can be found online at http://dx.doi.o", diff --git a/audit/2GN9LMCW/page_risk_summary.json b/audit/2GN9LMCW/page_risk_summary.json index 8f1fc144..889b6f10 100644 --- a/audit/2GN9LMCW/page_risk_summary.json +++ b/audit/2GN9LMCW/page_risk_summary.json @@ -34,8 +34,8 @@ "media_assets": 0, "table_like": 0, "captions": 0, - "hold": 0, - "unknown_structural": 0, + "hold": 1, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } @@ -186,18 +186,13 @@ }, { "page": 10, - "risk_score": 4, - "risk_reasons": [ - "same_page_boundary" - ], - "recommended_audit_targets": [ - "reading_order", - "same_page_boundary" - ], + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { - "body_paragraph": 4, + "body_paragraph": 6, "reference_item": 0, - "tail_like": 3, + "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, @@ -209,17 +204,21 @@ }, { "page": 11, - "risk_score": 5, + "risk_score": 13, "risk_reasons": [ - "reference_heading_present" + "reference_heading_present", + "mixed_body_reference", + "same_page_boundary" ], "recommended_audit_targets": [ - "reference_span" + "reading_order", + "reference_span", + "same_page_boundary" ], "counts": { - "body_paragraph": 0, + "body_paragraph": 8, "reference_item": 5, - "tail_like": 14, + "tail_like": 2, "media_assets": 0, "table_like": 0, "captions": 0, @@ -308,7 +307,6 @@ 6, 7, 9, - 10, 11 ] } \ No newline at end of file diff --git a/audit/2GN9LMCW/reference_intrusion_candidates.json b/audit/2GN9LMCW/reference_intrusion_candidates.json index 28628b0b..6c1c62d2 100644 --- a/audit/2GN9LMCW/reference_intrusion_candidates.json +++ b/audit/2GN9LMCW/reference_intrusion_candidates.json @@ -419,13 +419,6 @@ "role": "reference_item", "zone": "reference_zone", "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p15:4", - "page": 15, - "role": "noise", - "zone": "reference_zone", - "reason": "logical_order_between_reference_members" } ] } \ No newline at end of file diff --git a/audit/2GN9LMCW/reference_span_audit.json b/audit/2GN9LMCW/reference_span_audit.json index 5a7f1a03..7b997e8d 100644 --- a/audit/2GN9LMCW/reference_span_audit.json +++ b/audit/2GN9LMCW/reference_span_audit.json @@ -11,8 +11,8 @@ "end": { "page": 15, "column": 1, - "y": 1502.0, - "block_id": "p15:4" + "y": 377.0, + "block_id": "p15:3" }, "heading_block_id": "p11:14", "ordered_block_ids": [ @@ -22,7 +22,6 @@ "p11:17", "p11:18", "p11:19", - "p11:20", "p12:1", "p12:2", "p12:3", @@ -37,7 +36,6 @@ "p12:12", "p12:13", "p12:14", - "p12:15", "p13:1", "p13:2", "p13:3", @@ -50,7 +48,6 @@ "p13:10", "p13:11", "p13:12", - "p13:13", "p14:1", "p14:2", "p14:3", @@ -64,11 +61,9 @@ "p14:11", "p14:12", "p14:13", - "p14:14", "p15:1", "p15:2", - "p15:3", - "p15:4" + "p15:3" ], "inside_block_ids": [ "p11:14", @@ -77,7 +72,6 @@ "p11:17", "p11:18", "p11:19", - "p11:20", "p12:1", "p12:2", "p12:3", @@ -92,7 +86,6 @@ "p12:12", "p12:13", "p12:14", - "p12:15", "p13:1", "p13:2", "p13:3", @@ -105,7 +98,6 @@ "p13:10", "p13:11", "p13:12", - "p13:13", "p14:1", "p14:2", "p14:3", @@ -119,15 +111,13 @@ "p14:11", "p14:12", "p14:13", - "p14:14", "p15:1", "p15:2", - "p15:3", - "p15:4" + "p15:3" ], "explicitly_outside_nearby_block_ids": [ "p11:13", - "p15:5" + "p15:4" ], "intrusion_candidates": [ { @@ -549,13 +539,6 @@ "role": "reference_item", "zone": "reference_zone", "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p15:4", - "page": 15, - "role": "noise", - "zone": "reference_zone", - "reason": "logical_order_between_reference_members" } ] } diff --git a/audit/2H8MZ27H/audit_report.json b/audit/2H8MZ27H/audit_report.json new file mode 100644 index 00000000..396f3267 --- /dev/null +++ b/audit/2H8MZ27H/audit_report.json @@ -0,0 +1,332 @@ +{ + "paper_key": "2H8MZ27H", + "mode": "high-risk", + "status": "READY", + "focus": [], + "artifact_fingerprint": { + "result_json_hash": "sha256:6dfd52fa9863e70ed8ef92c562f085d63516b621a6d1c70d95b02f4db7a12a6c", + "meta_json_hash": "sha256:f632db0d4b1722e88a9f07cf03908be854ca8c1fe63631bbf2b3a52a42f233ef", + "blocks_raw_hash": "sha256:b64bb8a1c439ae1419c4bb6a2c347c0e692b51d1998bfee4544901e827ccc9bb", + "structured_blocks_hash": "sha256:2232792a574579bd0dfec424e5d239e4b1a01010c15d4b02fb6b2aaaa6b199d7", + "document_structure_hash": "sha256:c4357dc81853002e113bd8eba3a4a7902387b05a2137465ba65cad4b15f3100b", + "figure_inventory_hash": "sha256:34e883202173b17b72c9e3139299bcd7259d0ad429e57e394444411f4196d2fe", + "table_inventory_hash": "sha256:86ccb48fbfd41da91e87ea2c1ef938513732868efcb5e30b31c36f96d432bba2", + "reader_figures_hash": "sha256:d6892826ff7e806ad0b677c5c0dd6b5f243259d526e8dca97ee39baa0d0ab745", + "resolved_metadata_hash": "sha256:2c24a747cf483d8399b25beaa796a49a13ed3082fc5b1da0e17630c0fed1d5f0", + "fulltext_hash": "sha256:3b891c14a39929f078490adfd93df724dc7154e88a911b043fb9a95837278148", + "block_trace_hash": "sha256:a0decc69c33c2fa8a34c7c1efbdab61260ec54501a218eca3faa08d75992632b", + "annotated_pages": { + "page_001.png": "sha256:e412e3cc8e47df28e66aeb1fee6c8a09a6ec02a2a319f2e46ad5221cf1c3e6e0", + "page_002.png": "sha256:352fac4e65b04f44defa7641a9afff474a6bfc0eb0b6ed918ca6f701b7d3de73", + "page_003.png": "sha256:810421fe246a75e0125707b5fb73266406d73f12c38740db802cad7676647a78", + "page_004.png": "sha256:c6e09ba0e846974fd5cdb66c36a97e104361aa3b6d0df656a317b3f26c215a74", + "page_005.png": "sha256:30cf14809bf835d159b36bcb8b55993eb39ff3a6da1279bcfcd4b15d54e041d8", + "page_006.png": "sha256:88bcbdb12a0ed5e679e495dd2bccb441aea4696ce6aa365749c0128c6d990360", + "page_007.png": "sha256:449ced2fc1d19d7752fae4c695cd9db2e8ea88500a1d20dc37f57a6dfd87245f", + "page_008.png": "sha256:6f1047f87c03726f4e3e5044ab7006020b09f6fd0fb4464401e0835f5f8771d5" + } + }, + "artifact_freshness": { + "missing": [], + "mismatches": [ + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" + ], + "annotated_pages_rendered": [ + "page_001.png", + "page_002.png", + "page_003.png", + "page_004.png", + "page_005.png", + "page_006.png", + "page_007.png", + "page_008.png" + ] + }, + "reviewed_pages": [ + 1, + 2, + 3, + 4, + 5, + 6, + 7, + 8 + ], + "reviewed_blocks": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:8", + "p2:9", + "p2:10", + "p2:11", + "p2:12", + "p2:13", + "p2:14", + "p2:15", + "p2:16", + "p2:17", + "p2:18", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:4", + "p3:5", + "p3:6", + "p3:7", + "p3:8", + "p3:9", + "p3:10", + "p3:11", + "p3:12", + "p3:13", + "p3:14", + "p3:15", + "p3:16", + "p3:17", + "p3:18", + "p3:19", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p4:10", + "p4:11", + "p4:12", + "p4:13", + "p4:14", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p5:11", + "p5:12", + "p5:13", + "p5:14", + "p5:15", + "p5:16", + "p5:17", + "p6:0", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p6:5", + "p6:6", + "p6:7", + "p6:8", + "p6:9", + "p6:10", + "p6:11", + "p6:12", + "p6:13", + "p6:14", + "p6:15", + "p6:16", + "p6:17", + "p6:18", + "p6:19", + "p6:20", + "p6:21", + "p6:22", + "p6:23", + "p6:24", + "p7:0", + "p7:1", + "p7:2", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p7:12", + "p7:13", + "p7:14", + "p7:15", + "p7:16", + "p7:17", + "p7:18", + "p7:19", + "p7:20", + "p7:21", + "p7:22", + "p7:23", + "p7:24", + "p7:25", + "p7:26", + "p7:27", + "p7:28", + "p7:29", + "p7:30", + "p7:31", + "p7:32", + "p7:33", + "p7:34", + "p7:35", + "p7:36", + "p7:37", + "p7:38", + "p7:39", + "p7:40", + "p7:41", + "p7:42", + "p7:43", + "p7:44", + "p7:45", + "p7:46", + "p7:47", + "p7:48", + "p7:49", + "p7:50", + "p7:51", + "p7:52", + "p7:53", + "p7:54", + "p7:55", + "p7:56", + "p7:57", + "p7:58", + "p7:59", + "p8:0", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p8:9", + "p8:10", + "p8:11", + "p8:12", + "p8:13", + "p8:14" + ], + "findings": [ + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:2", + "p1:7", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:16", + "p2:17", + "p3:17", + "p3:18", + "p4:12", + "p4:13", + "p5:16", + "p6:23", + "p7:2", + "p7:50", + "p7:58", + "p8:5", + "p8:13" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/2H8MZ27H/audit_report.md b/audit/2H8MZ27H/audit_report.md new file mode 100644 index 00000000..3fb4e704 --- /dev/null +++ b/audit/2H8MZ27H/audit_report.md @@ -0,0 +1,20 @@ +# OCR Truth Audit Report - 2H8MZ27H + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 3, 4, 5, 6, 7, 8] +- Reviewed blocks: 190 + +## Findings + +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/2H8MZ27H/audit_scope.json b/audit/2H8MZ27H/audit_scope.json new file mode 100644 index 00000000..958a0e1d --- /dev/null +++ b/audit/2H8MZ27H/audit_scope.json @@ -0,0 +1,1966 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 3, + 4, + 5, + 6, + 7, + 8 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p2:1", + "p2:2", + "p2:11", + "p2:13", + "p2:14", + "p2:15", + "p3:1", + "p3:3", + "p3:5", + "p3:7", + "p3:8", + "p3:10", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p5:1", + "p5:2", + "p5:4", + "p5:5", + "p5:7", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p6:5", + "p6:6", + "p6:7", + "p6:8", + "p6:9", + "p6:10", + "p6:12", + "p6:13", + "p6:14", + "p6:15", + "p7:1", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p7:12", + "p7:13", + "p7:14", + "p7:15", + "p7:16", + "p7:17", + "p7:18", + "p7:19", + "p7:20", + "p7:21", + "p7:22", + "p7:23", + "p7:24", + "p7:25", + "p7:26", + "p7:27", + "p7:28", + "p7:29", + "p7:30", + "p7:31", + "p7:32", + "p7:33", + "p7:34", + "p7:35", + "p7:36", + "p7:37", + "p7:38", + "p7:39", + "p7:40", + "p7:41", + "p7:42", + "p7:43", + "p7:44", + "p7:45", + "p7:46", + "p7:47", + "p7:48", + "p7:49", + "p7:50", + "p7:51", + "p7:52", + "p7:53", + "p7:54", + "p7:55", + "p7:56", + "p7:57", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p8:9", + "p8:10", + "p8:11", + "p8:12" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + 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+page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[38.0, 36.0, 368.0, 196.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header_image,,"[603.0, 1.0, 1188.0, 199.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,text,OPEN,"[157.0, 300.0, 243.0, 331.0]",authors,0.6,"[""page-1 initial-lastname author byline: OPEN""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,3,text,"SUBJECT AREAS: +BIONANOELECTRONICS +BIOLOGICAL MODELS","[68.0, 381.0, 244.0, 466.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,doc_title,Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/ $ \beta $-catenin Signaling Pathway,"[282.0, 283.0, 1048.0, 521.0]",paper_title,0.8,"[""page-1 zone title_zone: Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotyp""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,Received 12 December 2013,"[91.0, 503.0, 244.0, 550.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Received 12 December 2013""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,6,text,Accepted,"[164.0, 560.0, 244.0, 583.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Accepted""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,short_fragment,False,False +1,7,text,8 July 2014,"[147.0, 582.0, 243.0, 607.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,reference_like,reference_numeric_dot,False,False +1,8,text,Published,"[150.0, 614.0, 244.0, 638.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Published""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False +1,9,text,25 July 2014,"[137.0, 637.0, 244.0, 663.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,reference_like,reference_numeric_dot,False,False +1,10,text,"Correspondence and requests for materials should be addressed to Z.G.G. (gez@pku.edu.cn) or J.Z. (zhangjue@pku.edu.cn) +Kun Zhang $ ^{1} $, Jinsong Guo $ ^{2} $, Zigang Ge $ ^{1,3,4} $ & Jue Zhang $ ^{","[81.0, 712.0, 246.0, 858.0]",frontmatter_support,0.78,"[""first-surviving-page support text: Correspondence and requests for materials should be addresse""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True +1,11,text,"Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5","[282.0, 535.0, 743.0, 564.0]",authors,0.8,"[""page-1 zone author_zone: Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,12,text," $ ^{1} $Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China, $ ^{2} $Institute of Biomechaics and Biomedical Engineering, College of Engineering, P","[281.0, 598.0, 1110.0, 703.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $Department of Biomedical Engineering, College of Eng""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,13,abstract,"Nanosecond pulsed electric fields (nsPEFs) characterized by high voltage, low energy and non-thermal effects, have been broadly investigated as a potential tumor therapy; however, little is known abou","[280.0, 737.0, 1111.0, 947.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,14,text,"M illisecond or microsecond pulsed electric fields (PEFs) have been shown to facilitate delivery of drugs and transfer of genes into cells $ ^{1,2} $. PEFs induce a transient transmembrane potential o","[281.0, 977.0, 1111.0, 1297.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,text,"Chondrocytes are critical for maintenance and regeneration of cartilage, and several signaling pathways regulate phenotypes of differentiation, hypertrophy, proliferation, and dedifferentiation. Trans","[281.0, 1297.0, 1112.0, 1492.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1520.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,17,number,1,"[1094.0, 1523.0, 1107.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,0,header,www.nature.com/scientificreports,"[761.0, 30.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[1125.0, 1.0, 1191.0, 74.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +2,2,image,,"[79.0, 96.0, 581.0, 552.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,3,figure_title,Figure 1 | Strategic map exploring the effects of nsPEFs on chondrocytes.,"[80.0, 566.0, 587.0, 590.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 1 | Strategic map exploring the effects of nsPEFs on ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +2,4,text,"ments were used in the aforementioned research due to the thermal effects of PEFs. Although the biological effects induced by nsPEFs are largely unknown, it has been reported that MAPK pathways, gener","[79.0, 614.0, 588.0, 743.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"In this study, we evaluated the phenotypic effects of nsPEFs on chondrocytes and found that nsPEFs enhanced cell proliferation while causing dedifferentiation by upregulating gene expression of type I","[80.0, 743.0, 589.0, 832.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"II. We then explored whether activation of the wnt/b-catenin signal- +ing pathway was involved in these phenotypic changes (Fig. 1).","[602.0, 99.0, 1108.0, 146.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,Results,"[602.0, 163.0, 681.0, 185.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True +2,8,text,"nsPEFs enhance proliferation of chondrocytes. Based on favorable results obtained in previous reports and our pilot study, 5 pulses of 100 ns nsPEFs at 10 or 20 kV/cm were used in this current study $","[600.0, 187.0, 1111.0, 525.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"nsPEFs downregulate glycosaminoglycan (GAG) production. Results obtained demonstrated that nsPEFs at 10 kV/cm decreased GAG production at day 1 (0.91-fold), day 3 (0.96-fold) and day 7 (0.97-fold). Mo","[600.0, 538.0, 1111.0, 773.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,nsPEFs downregulate expression of functional genes. Effects of nsPEFs on gene expression were evaluated at 1 hour and 24 hours,"[601.0, 784.0, 1112.0, 830.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,chart,,"[232.0, 867.0, 581.0, 1110.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,12,figure_title,b,"[611.0, 857.0, 636.0, 889.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +2,13,chart,,"[610.0, 869.0, 954.0, 1108.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,14,chart,,"[237.0, 1134.0, 581.0, 1378.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,15,chart,,"[605.0, 1131.0, 954.0, 1377.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,16,figure_title,"Figure 2 | Induction of dedifferentiated phenotype of chondrocytes after nsPEF treatment. (a) The toxicity of nsPEFs at 10 kV/cm and 20 kV/cm was evaluated at days 1, 3 and 7. nsPEFs had a nontoxic ef","[80.0, 1388.0, 1110.0, 1497.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 2 | Induction of dedifferentiated phenotype of chondr""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +2,17,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1520.0, 518.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,18,number,2,"[1092.0, 1522.0, 1110.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,www.nature.com/scientificreports,"[761.0, 30.0, 1109.0, 54.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[1125.0, 1.0, 1191.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +3,2,figure_title,a,"[218.0, 112.0, 242.0, 137.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,3,chart,,"[219.0, 114.0, 581.0, 369.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,b,"[606.0, 105.0, 630.0, 137.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,5,chart,,"[606.0, 110.0, 976.0, 368.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,C,"[218.0, 387.0, 241.0, 414.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,7,chart,,"[220.0, 389.0, 582.0, 641.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,8,chart,,"[607.0, 383.0, 976.0, 642.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,9,figure_title,e,"[216.0, 656.0, 242.0, 682.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,10,chart,,"[211.0, 666.0, 580.0, 911.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,11,figure_title,Figure 3 | Functional gene expression of chondrocytes after nsPEF treatment. Gene expression was analyzed at 1 hour for immediate effects and following a recovery period of 24 hours after 10 kV/cm and,"[78.0, 924.0, 1107.0, 1011.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 3 | Functional gene expression of chondrocytes after ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +3,12,text,"after nsPEF treatment. At 1 hour, nsPEFs at 10 kV/cm decreased gene expression of COL II significantly to 0.43-fold (p = 0.017), while nsPEFs at 20 kV/cm decreased COL II gene expression to 0.45-fold ","[79.0, 1033.0, 588.0, 1286.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,text,"At 24 hours after nsPEF treatment, gene expression showed an increase compared to the gene expression at 1 hour. An additive effect of COL I was indicated by an increase in the gene expression to 1.75","[79.0, 1287.0, 588.0, 1434.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,text,"nsPEFs activate wnt/β-catenin signaling pathway. Expression of β-catenin protein increased significantly by 45% (p = 0.005) and 42% (p = 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment, resp","[80.0, 1453.0, 588.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,text,"(p 5 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment, +respectively (Fig. 4a, b). As shown, b-catenin accumulated in the +nucleus of the cells after nsPEF treatment (Fig. 4c). 10 kV/cm and +20 ","[601.0, 1033.0, 1111.0, 1288.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,16,text,"Our findings demonstrated that after 24 hours, nsPEFs induced a decrease in Lef1 and c-jun gene expression in comparison to the gene expression observed after 1 hour. nsPEFs increased gene expression ","[601.0, 1287.0, 1111.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,17,text,Inhibition of wnt/ $ \beta $-catenin pathway partially blocks effects of nsPEFs. Incubation with XAV939 reverted nsPEF-induced upregulation of $ \beta $-,"[601.0, 1453.0, 1109.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,18,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1521.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,19,number,3,"[1093.0, 1523.0, 1109.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,www.nature.com/scientificreports,"[761.0, 31.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header_image,,"[1126.0, 1.0, 1191.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +4,2,chart,,"[109.0, 114.0, 324.0, 272.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,3,chart,,"[364.0, 103.0, 577.0, 322.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,4,image,,"[102.0, 333.0, 550.0, 760.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,5,figure_title,Figure 4 | Activated wnt/β-catenin signaling pathway after nsPEF treatment. (a) β-catenin protein expression performed with western blotting analysis using specific antibodies for β-catenin at 1 hour ,"[80.0, 776.0, 588.0, 966.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 4 | Activated wnt/\u03b2-catenin signaling pathway after n""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +4,6,text,"catenin (Fig. 6j–6l), wnt7a gene (Fig. 6d) and the downstream genes of wnt, Lef1 (Fig. 6a), c-jun (Fig. 6b) and cyclin D1 (Fig. 6c) by inhibition ranging from 30% to 60%. When the effects of inhibitio","[79.0, 989.0, 588.0, 1307.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,paragraph_title,Discussion,"[81.0, 1326.0, 190.0, 1347.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,8,text,nsPEFs have profound effects on multiple organelles of a cell. nsPEFs generate large transmembrane potentials across cellular organelles with limited thermal effects. The most significant characterist,"[79.0, 1348.0, 589.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,"pulse duration decreases, the outer membrane is likely shorted, and +the applied voltage appears mainly across the interior organelles of +the cell27. nsPEFs modify the potential and phosphatidylserine ","[602.0, 100.0, 1112.0, 312.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,"Effects of nsPEFs are usually transient. Typically, the nanopores can be formed within 5 nanoseconds after nsPEF treatment $ ^{7} $. Calcium ions efflux from the endoplasmic reticulum within 10 second","[601.0, 314.0, 1111.0, 630.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,Fine-tuned activation of the wnt/β-catenin signaling pathway is essential to regulate the fate of chondrocytes in cartilage. The wnt/β-catenin pathway is involved in dedifferentiation of cultured chon,"[602.0, 629.0, 1111.0, 1074.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,The fact that inhibition of the wnt/ $ \beta $-catenin signaling can only partially block the effects of nsPEFs on chondrocytes hints that there are other mechanisms involved. The functional crosstalk,"[601.0, 1073.0, 1112.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1520.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,14,number,4,"[1093.0, 1523.0, 1109.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,www.nature.com/scientificreports,"[761.0, 30.0, 1110.0, 54.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header_image,,"[1125.0, 1.0, 1191.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +5,2,chart,,"[251.0, 111.0, 587.0, 354.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,b,"[597.0, 104.0, 620.0, 136.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,4,chart,,"[597.0, 111.0, 934.0, 353.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,chart,,"[255.0, 370.0, 589.0, 613.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,figure_title,d,"[597.0, 365.0, 622.0, 395.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,7,chart,,"[593.0, 372.0, 935.0, 611.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,figure_title,"Figure 5 | Influence of nsPEFs on gene expression related to wnt/ $ \beta $-catenin signaling. Gene expression was detected immediately at 1 hour and following a 24 hour recovery after 0, 10 and 20 kV","[80.0, 623.0, 1109.0, 688.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 5 | Influence of nsPEFs on gene expression related to""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +5,9,text,"due to its folded spiral structure, it is sensitive to nsPEFs and forms speckles after nsPEF treatment $ ^{28} $. nsPEFs induce small nuclear ribonucleoprotein particles and RNA-protein complexes, whi","[79.0, 710.0, 588.0, 987.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"nsPEFs may have different effects on suspended and attached cells in vitro. Cells in a suspended state were subjected to nsPEFs within electric cuvettes, which provided an instantaneous and consistent","[79.0, 987.0, 589.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,"development of a real-time visual microfluidic system for monitoring +adherent cells combined with nsPEFs52.","[601.0, 710.0, 1110.0, 753.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,text,"As nsPEFs do not exist in a natural cellular environment, a comprehensive understanding of nsPEFs as well as the effects of superficial stimuli need to be further explored to determine any difference ","[600.0, 756.0, 1112.0, 1011.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,paragraph_title,Methods,"[603.0, 1042.0, 696.0, 1064.0]",section_heading,0.9,"[""explicit scholarly heading: Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +5,14,text,"Cell culture. Porcine articular cartilage tissue was cut into small pieces by a lancet, and washed with phosphate-buffered saline (PBS). The tissue pieces were collected and digested in 0.1% Collagena","[601.0, 1069.0, 1110.0, 1313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,15,text,"Application of nsPEFs. The nsPEF generator was applied as previously described $ ^{54} $. Digital phosphor oscilloscope (DPO4054, Tektronix) with a probe (P6015A, Tektronix) was utilized to monitor th","[601.0, 1339.0, 1112.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,16,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1521.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,17,number,5,"[1093.0, 1523.0, 1108.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,www.nature.com/scientificreports,"[762.0, 30.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header_image,,"[1125.0, 1.0, 1190.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +6,2,chart,,"[102.0, 104.0, 287.0, 319.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,3,chart,,"[302.0, 112.0, 493.0, 320.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,4,chart,,"[500.0, 111.0, 701.0, 319.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,chart,,"[703.0, 113.0, 899.0, 319.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,6,chart,,"[902.0, 119.0, 1101.0, 320.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,7,chart,,"[89.0, 344.0, 289.0, 545.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,chart,,"[294.0, 342.0, 494.0, 545.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,chart,,"[502.0, 344.0, 704.0, 544.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,10,chart,,"[717.0, 341.0, 918.0, 544.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,11,figure_title,j,"[105.0, 571.0, 120.0, 602.0]",figure_inner_text,0.9,"[""panel label / figure inner text: j""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,12,image,,"[101.0, 569.0, 352.0, 778.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,13,chart,,"[376.0, 573.0, 578.0, 788.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,14,chart,,"[611.0, 561.0, 860.0, 796.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,15,image,,"[612.0, 559.0, 1065.0, 796.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,16,figure_title,"Figure 6 | Influence of inhibition of wnt/ $ \beta $-catenin signaling on gene and protein expression after nsPEF treatment. Gene expression was detected at 1 hour after 0, 10 and 20 kV/cm nsPEF treat","[77.0, 812.0, 1112.0, 960.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 6 | Influence of inhibition of wnt/ $ \\beta $-catenin""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +6,17,text,"Celltoxicity. The toxicity of nsPEFs was evaluated by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT, M2128, Sigma) at days 1, 3 and 7.5.0 × 10³ chondrocytes/well were seeded in","[80.0, 982.0, 589.0, 1121.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,18,text,"Cell proliferation. Cell proliferation was assayed with Hoechst 33258 (H6024, Sigma) at days 1, 3 and 7. Chondrocytes in each well were lysed with 100 μL sterile distilled DNAse-free H₂O, and the diss","[80.0, 1135.0, 587.0, 1258.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,19,text,"GAG content. Chondrocytes were digested in 0.5 mg/mL proteinase K at 56°C for 12 hours, and were subsequently examined with dimethylmethylene blue (DMMB, 341088, Sigma). The digestive solution was sha","[79.0, 1272.0, 587.0, 1396.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,20,text,"Gene expression. Total RNA was extracted and isolated from chondrocytes with Trizol Reagent (206101, New Industry) following the standard protocol, and quantified with Nanodrop spectrophotometer (ND-1","[80.0, 1409.0, 588.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,21,text,"cycler (Mycycler, Bio-Rad). Quantitative real-time PCR was performed in the PCR +system (Pikoreal 96, Thermo) with RealMasterMix SYBR Green (FP202, Tiangen) +following the manufacturer’s procedures. The","[601.0, 982.0, 1111.0, 1374.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,22,text,"Western blotting. Chondrocytes were lysed by RIPA lysis buffer (R0020, Solarbio) with fresh protease inhibitor of 0.1% phenylmethanesulfonyl fluoride (PMSF, Solarbio). Total cell lysate was boiled aft","[602.0, 1391.0, 1108.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,23,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1521.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,24,number,6,"[1093.0, 1523.0, 1109.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,www.nature.com/scientificreports,"[761.0, 31.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,1,header_image,,"[1125.0, 1.0, 1190.0, 74.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +7,2,text,"and $ \beta $-actin (4970, Cell Signaling) was combined with HRP-linked antibody of anti-rabbit IgG (7074, Cell Signaling). The complex of the antigen and the antibody was illuminated by chemilumines","[89.0, 98.0, 591.0, 171.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"Immunofluorescence. Immunofluorescence was utilized to confirm the location of $ \beta $-catenin protein. After nsPEF treatment, chondrocytes were fixed with 4% paraformaldehyde for 15 minutes and wa","[81.0, 189.0, 586.0, 329.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,Statistical analysis. Analysis was performed using SPSS V13.0 (SPSS Inc.) one-way ANOVA with the least significant difference (LSD) test (data presented as mean ± s.d). The statistical significance wa,"[81.0, 348.0, 585.0, 419.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,reference_content,"1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Membrane electroporation theories: a review. Med. Biol. Eng. Comput. 44, 5–14 (2006).","[82.0, 452.0, 586.0, 486.0]",reference_item,0.85,"[""reference content label: 1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Mem""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,6,reference_content,"2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Nanosecond Pulsed Electric Fields into He La Cells Expressing Enhanced Green Fluorescent Protein and Fluorescence Lifetime Microscopy. J. Phys","[83.0, 487.0, 586.0, 553.0]",reference_item,0.85,"[""reference content label: 2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Na""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,7,reference_content,"3. Weaver, J. C. Electroporation of biological membranes from multicellular to nano scales. IEEE Trans. Dielectr. Electr. 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Demonstration of cell m""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,10,reference_content,"6. Rems, L. et al. Cell electrofusion using nanosecond electric pulses. Sci. Rep. 3, 3382; doi:10.1038/srep03382 (2013).","[84.0, 678.0, 587.0, 712.0]",reference_item,0.85,"[""reference content label: 6. Rems, L. et al. Cell electrofusion using nanosecond elect""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,11,reference_content,"7. Hu, Q., Joshi, R. P. & Schoenbach, K. H. Simulations of nanopore formation and phosphatidylserine externalization in lipid membranes subjected to a high-intensity, ultrashort electric pulse. Phys. ","[83.0, 713.0, 586.0, 765.0]",reference_item,0.85,"[""reference content label: 7. Hu, Q., Joshi, R. P. & Schoenbach, K. H. Simulations of n""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,12,reference_content,"8. Schoenbach, K. H., Beebe, S. J. & Buescher, E. S. Intracellular effect of ultrashort electrical pulses. Bioelectromagnetics 22, 440–448 (2001).","[83.0, 765.0, 586.0, 799.0]",reference_item,0.85,"[""reference content label: 8. Schoenbach, K. H., Beebe, S. J. & Buescher, E. S. Intrace""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,13,reference_content,"9. White, J. A., Blackmore, P. F., Schoenbach, K. H. & Beebe, S. J. Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields. J. Biol. Chem. 279, 22964–22972 (2004","[84.0, 801.0, 577.0, 851.0]",reference_item,0.85,"[""reference content label: 9. White, J. A., Blackmore, P. F., Schoenbach, K. H. & Beebe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,14,reference_content,"10. Morotomi-Yano, K., Akiyama, H. & Yano, K. Nanosecond pulsed electric fields activate MAPK pathways in human cells. Arch. Biochem. Biophys. 515, 99–106 (2011).","[85.0, 852.0, 583.0, 903.0]",reference_item,0.85,"[""reference content label: 10. Morotomi-Yano, K., Akiyama, H. & Yano, K. Nanosecond pul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,15,reference_content,"11. Garon, E. B. et al. In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies. Int. J. Cancer 121, 675–682 (2007).","[84.0, 905.0, 585.0, 956.0]",reference_item,0.85,"[""reference content label: 11. Garon, E. B. et al. In vitro and in vivo evaluation and ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,16,reference_content,"12. Ren, W., Sain, N. M. & Beebe, S. J. Nanosecond pulsed electric fields (nsPEFs) activate intrinsic caspase-dependent and caspase-independent cell death in Jurkat cells. Biochem. Biophys. Res. Commu","[85.0, 957.0, 586.0, 1008.0]",reference_item,0.85,"[""reference content label: 12. Ren, W., Sain, N. M. & Beebe, S. J. Nanosecond pulsed el""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,17,reference_content,"13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. & Stacey, M. W. Enhanced Killing Effect of Nanosecond Pulse Electric Fields on PANC1 and Jurkat Cell Lines in the Presence of Tween 80. The ","[85.0, 1010.0, 587.0, 1076.0]",reference_item,0.85,"[""reference content label: 13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,18,reference_content,"14. van der Kraan, P. M., Davidson, E. N. B., Blom, A. & van den Berg, W. B. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis Modulation and integration of signaling pathw","[84.0, 1079.0, 585.0, 1146.0]",reference_item,0.85,"[""reference content label: 14. van der Kraan, P. M., Davidson, E. N. B., Blom, A. & van""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,19,reference_content,"15. Grimsrud, C. D. et al. BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog. Journal of Orthopaedic Research 19, 18–25 (2001).","[85.0, 1148.0, 587.0, 1183.0]",reference_item,0.85,"[""reference content label: 15. Grimsrud, C. D. et al. BMP signaling stimulates chondroc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,20,reference_content,"16. Riemer, S., Gebhard, S., Beier, F., Poschl, E. & von der Mark, K. Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: Localization of a PTH/PTHrP-responsive region","[85.0, 1184.0, 588.0, 1250.0]",reference_item,0.85,"[""reference content label: 16. Riemer, S., Gebhard, S., Beier, F., Poschl, E. & von der""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,21,reference_content,"17. Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocyte phenotype by beta-catenin. Mol Biol Cell 13, 118a–118a (2002).","[85.0, 1252.0, 575.0, 1287.0]",reference_item,0.85,"[""reference content label: 17. Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocy""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,22,reference_content,"18. Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. 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All authors revie","[81.0, 334.0, 578.0, 388.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,7,paragraph_title,Additional information,"[604.0, 100.0, 829.0, 122.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Additional information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True +8,8,text,Supplementary information accompanies this paper at http://www.nature.com/scientificreports,"[602.0, 122.0, 1057.0, 158.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,9,text,Competing financial interests: The authors declare no competing financial interests.,"[602.0, 163.0, 1083.0, 181.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,10,text,"How to cite this article: Zhang, K., Guo, J., Ge, Z. & Zhang, J. 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(gez@pku", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:11", + "page": 1, + "role": "authors", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:12", + "page": 1, + "role": "affiliation", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "$ ^{1} $Department of Biomedical Engineering, College of Engineering, Peking Uni", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:14", + "page": 1, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "M illisecond or microsecond pulsed electric fields (PEFs) have been shown to fac", + "found_in_fulltext": true, + "fulltext_offset": 1379 + }, + { + "block_id": "p1:15", + "page": 1, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Chondrocytes are critical for maintenance and regeneration of cartilage, and sev", + "found_in_fulltext": true, + "fulltext_offset": 3034 + }, + { + "block_id": "p1:16", + "page": 1, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:17", + "page": 1, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "1", + "found_in_fulltext": true, + "fulltext_offset": 255 + }, + { + "block_id": "p2:0", + "page": 2, + "role": "noise", + "zone": "frontmatter_side_zone", + "render_default": false, + "snippet": "www.nature.com/scientificreports", + "found_in_fulltext": true, + "fulltext_offset": 39760 + }, + { + "block_id": "p2:4", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "ments were used in the aforementioned research due to the thermal effects of PEF", + "found_in_fulltext": true, + "fulltext_offset": 4037 + }, + { + "block_id": "p2:5", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In this study, we evaluated the phenotypic effects of nsPEFs on chondrocytes and", + "found_in_fulltext": true, + "fulltext_offset": 4406 + }, + { + "block_id": "p2:6", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "II. 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Typically, the nanopores can be formed ", + "found_in_fulltext": true, + "fulltext_offset": 13377 + }, + { + "block_id": "p4:11", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Fine-tuned activation of the wnt/β-catenin signaling pathway is essential to reg", + "found_in_fulltext": true, + "fulltext_offset": 14351 + }, + { + "block_id": "p4:12", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The fact that inhibition of the wnt/ $ \\beta $-catenin signaling can only partia", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:13", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:14", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "4", + "found_in_fulltext": true, + "fulltext_offset": 256 + }, + { + "block_id": "p5:0", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "www.nature.com/scientificreports", + "found_in_fulltext": true, + "fulltext_offset": 39760 + }, + { + "block_id": "p5:9", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "due to its folded spiral structure, it is sensitive to nsPEFs and forms speckles", + "found_in_fulltext": true, + "fulltext_offset": 17172 + }, + { + "block_id": "p5:10", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "nsPEFs may have different effects on suspended and attached cells in vitro. Cell", + "found_in_fulltext": true, + "fulltext_offset": 18055 + }, + { + "block_id": "p5:11", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "development of a real-time visual microfluidic system for monitoring adherent ce", + "found_in_fulltext": true, + "fulltext_offset": 19673 + }, + { + "block_id": "p5:12", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "As nsPEFs do not exist in a natural cellular environment, a comprehensive unders", + "found_in_fulltext": true, + "fulltext_offset": 19895 + }, + { + "block_id": "p5:13", + "page": 5, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Methods", + "found_in_fulltext": true, + "fulltext_offset": 20667 + }, + { + "block_id": "p5:14", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Cell culture. Porcine articular cartilage tissue was cut into small pieces by a ", + "found_in_fulltext": true, + "fulltext_offset": 20675 + }, + { + "block_id": "p5:15", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Application of nsPEFs. The nsPEF generator was applied as previously described $", + "found_in_fulltext": true, + "fulltext_offset": 21705 + }, + { + "block_id": "p5:16", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:17", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "5", + "found_in_fulltext": true, + "fulltext_offset": 282 + }, + { + "block_id": "p6:0", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "www.nature.com/scientificreports", + "found_in_fulltext": true, + "fulltext_offset": 39760 + }, + { + "block_id": "p6:17", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Celltoxicity. The toxicity of nsPEFs was evaluated by 3-(4,5-Dimethyl-2-thiazoly", + "found_in_fulltext": true, + "fulltext_offset": 22425 + }, + { + "block_id": "p6:18", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Cell proliferation. Cell proliferation was assayed with Hoechst 33258 (H6024, Si", + "found_in_fulltext": true, + "fulltext_offset": 23060 + }, + { + "block_id": "p6:19", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "GAG content. Chondrocytes were digested in 0.5 mg/mL proteinase K at 56°C for 12", + "found_in_fulltext": true, + "fulltext_offset": 23580 + }, + { + "block_id": "p6:20", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Gene expression. Total RNA was extracted and isolated from chondrocytes with Tri", + "found_in_fulltext": true, + "fulltext_offset": 24122 + }, + { + "block_id": "p6:21", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "cycler (Mycycler, Bio-Rad). Quantitative real-time PCR was performed in the PCR ", + "found_in_fulltext": true, + "fulltext_offset": 24508 + }, + { + "block_id": "p6:22", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Western blotting. Chondrocytes were lysed by RIPA lysis buffer (R0020, Solarbio)", + "found_in_fulltext": true, + "fulltext_offset": 27797 + }, + { + "block_id": "p6:23", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:24", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "6", + "found_in_fulltext": true, + "fulltext_offset": 285 + }, + { + "block_id": "p7:0", + "page": 7, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "www.nature.com/scientificreports", + "found_in_fulltext": true, + "fulltext_offset": 39760 + }, + { + "block_id": "p7:2", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "and $ \\beta $-actin (4970, Cell Signaling) was combined with HRP-linked antibody", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:3", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Immunofluorescence. Immunofluorescence was utilized to confirm the location of $", + "found_in_fulltext": true, + "fulltext_offset": 28662 + }, + { + "block_id": "p7:4", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Statistical analysis. Analysis was performed using SPSS V13.0 (SPSS Inc.) one-wa", + "found_in_fulltext": true, + "fulltext_offset": 29309 + }, + { + "block_id": "p7:5", + "page": 7, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Membrane electroporatio", + "found_in_fulltext": true, + "fulltext_offset": 29580 + }, + { + "block_id": "p7:6", + "page": 7, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Nanosecond Pulsed Elec", + "found_in_fulltext": true, + "fulltext_offset": 29723 + }, + { + "block_id": "p7:7", + "page": 7, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "3. Weaver, J. C. Electroporation of biological membranes from multicellular to n", + "found_in_fulltext": true, + "fulltext_offset": 29958 + }, + { + "block_id": "p7:8", + "page": 7, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "4. Schoenbach, K. H. et al. Ultrashort electrical pulses open a new gateway into", + "found_in_fulltext": true, + "fulltext_offset": 30107 + }, + { + "block_id": "p7:9", + "page": 7, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "5. Silve, A., Leray, I. & Mir, L. M. 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index 00000000..dd191b88 --- /dev/null +++ b/audit/2H8MZ27H/reference_span_audit.json @@ -0,0 +1,12 @@ +{ + "reference_span": { + "status": "HOLD", + "span_id": null, + "start": null, + "end": null, + "ordered_block_ids": [], + "inside_block_ids": [], + "explicitly_outside_nearby_block_ids": [], + "intrusion_candidates": [] + } +} \ No newline at end of file diff --git a/audit/2HEUD5P9/audit_report.json b/audit/2HEUD5P9/audit_report.json new file mode 100644 index 00000000..57db4da2 --- /dev/null +++ b/audit/2HEUD5P9/audit_report.json @@ -0,0 +1,523 @@ +{ + "paper_key": "2HEUD5P9", + "mode": "high-risk", + "status": "READY", + "focus": [], + "artifact_fingerprint": { + "result_json_hash": "sha256:228d05fc7b34c8528df7b30187f7c227618e92774fa2fc9828dd6986d8b66ba5", + "meta_json_hash": "sha256:1908715a6346b6c18f33636fe2da9eead16ef481869e28b11bb1ca75b3c0661b", + "blocks_raw_hash": "sha256:c9bf76e82e5fd66c3ef9cbf9fe91d3b35657c59a8f73890f281011ee4b548206", + "structured_blocks_hash": 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"p19:0", + "p19:1", + "p19:2", + "p19:3", + "p19:4", + "p19:5", + "p19:6", + "p19:7", + "p19:8", + "p19:9", + "p19:10", + "p19:11", + "p19:12", + "p21:0", + "p21:1", + "p21:2", + "p21:3", + "p21:4", + "p21:5", + "p21:6", + "p21:7", + "p21:8", + "p21:9", + "p21:10", + "p21:11", + "p21:12", + "p21:13", + "p21:14", + "p21:15", + "p21:16", + "p21:17", + "p21:18", + "p21:19", + "p21:20", + "p21:21", + "p23:0", + "p23:1", + "p23:2", + "p23:3", + "p23:4", + "p23:5", + "p23:6", + "p23:7", + "p23:8", + "p23:9", + "p23:10", + "p23:11", + "p23:12", + "p23:13", + "p23:14", + "p23:15", + "p23:16", + "p23:17", + "p23:18", + "p23:19", + "p23:20", + "p23:21", + "p23:22", + "p23:23", + "p23:24", + "p23:25", + "p23:26", + "p23:27", + "p23:28", + "p23:29", + "p23:30", + "p23:31", + "p23:32", + "p23:33", + "p23:34", + "p23:35", + "p23:36", + "p23:37", + "p23:38", + "p23:39", + "p23:40", + "p23:41", + "p23:42", + "p23:43", + "p23:44", + "p23:45", + "p23:46", + "p23:47", + "p23:48", + "p23:49", + "p23:50", + "p23:51", + "p23:52", + "p23:53", + "p23:54", + "p23:55", + "p23:56", + "p23:57", + "p23:58", + "p23:59", + "p26:0", + "p26:1", + "p26:2", + "p26:3", + "p26:4", + "p26:5", + "p26:6", + "p26:7", + "p26:8", + "p26:9", + "p26:10", + "p26:11", + "p26:12", + "p26:13", + "p26:14", + "p26:15", + "p26:16", + "p26:17", + "p26:18", + "p26:19", + "p26:20", + "p26:21", + "p26:22", + "p26:23", + "p26:24", + "p26:25", + "p26:26", + "p26:27", + "p26:28", + "p27:0", + "p27:1", + "p27:2", + "p27:3", + "p27:4", + "p27:5", + "p27:6", + "p27:7", + "p27:8", + "p27:9", + "p27:10", + "p27:11", + "p27:12" + ], + "findings": [ + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_023.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:2", + "p1:3", + "p1:8", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p2:0", + "p2:2", + "p2:3", + "p2:4", + "p2:6", + "p2:12", + "p2:13", + "p2:14", + "p2:15", + "p3:0", + "p3:4", + "p3:9" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/2HEUD5P9/audit_report.md b/audit/2HEUD5P9/audit_report.md new file mode 100644 index 00000000..0cb7594c --- /dev/null +++ b/audit/2HEUD5P9/audit_report.md @@ -0,0 +1,17 @@ +# OCR Truth Audit Report - 2HEUD5P9 + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 4, 6, 9, 10, 12, 13, 15, 17, 19, 21, 23, 26, 27] +- Reviewed blocks: 371 + +## Findings + +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/2HEUD5P9/audit_scope.json b/audit/2HEUD5P9/audit_scope.json new file mode 100644 index 00000000..f13d07fe --- /dev/null +++ b/audit/2HEUD5P9/audit_scope.json @@ -0,0 +1,3128 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 3, + 4, + 6, + 9, + 10, + 12, + 13, + 15, + 17, + 19, + 21, + 23, + 26, + 27 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + 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Bone tissue defects, infections, illnesses, and dislocations can impair the quality of life of a patient.[1] Autograft and allograft techniques are often used to treat bone-related diseases","[781.0, 389.0, 1099.0, 870.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,9,footnote,"Y. Bai, Z. Wang, X. He, Y. Zhu, X. Xu, H. Yang, G. Mei, S. Chen, B. Ma, R. Zhu +Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education +Department of Orthopedics","[96.0, 993.0, 584.0, 1365.0]",footnote,0.7,"[""footnote label: Y. Bai, Z. Wang, X. He, Y. Zhu, X. Xu, H. Yang, G. Mei, S. C""]",footnote,0.7,body_zone,body_like,none,True,True +1,10,text,"Bone regeneration requires effective solutions for bone loss and defects, which are prominent clinical challenges in orthopedic surgery. 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Cartilage serves as a template for subsequent bone formation via endochondral ossification.[9] Th,"[605.0, 1178.0, 1099.0, 1443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,12,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smtd.202301283,"[99.0, 1375.0, 588.0, 1414.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,13,footer,DOI: 10.1002/smtd.202301283,"[97.0, 1420.0, 336.0, 1443.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,14,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,15,footer,2301283 (1 of 27),"[530.0, 1484.0, 664.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,16,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[896.0, 36.0, 1091.0, 117.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,2,text,"specific differentiation pathways, thereby improving bone healing and osteogenesis. $ ^{[12]} $ Therefore, scaffolds should possess a considerable capacity for the delivery of these factors. In additi","[89.0, 148.0, 582.0, 281.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Bioactive composite 3D porous scaffolds can improve the outcomes of bone-defect repair, including osteoconduction (bone cell infiltration into scaffolds), osseointegration (firm attachment of scaffold","[89.0, 281.0, 582.0, 676.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,Osteoconductivity and osteoinductivity of biomaterials has significant importance in clinical applications. The design of bone tissue engineering materials requires an understanding of the composition,"[90.0, 675.0, 582.0, 1158.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Multiple biomaterials have been used in bone tissue repair and regeneration to date, largely owing to their unique properties. This review summarizes several biomaterials and advanced techniques and i","[89.0, 1157.0, 583.0, 1402.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,paragraph_title,2. Main Types of Bone Biomaterials,"[601.0, 149.0, 945.0, 176.0]",paper_title,0.6,"[""page-1 frontmatter title guard: 2. Main Types of Bone Biomaterials""]",paper_title,0.6,frontmatter_main_zone,reference_like,reference_numeric_dot,True,True +2,7,paragraph_title,2.1. Ceramics,"[602.0, 187.0, 711.0, 210.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Ceramics""]",subsection_heading,0.85,frontmatter_side_zone,support_like,heading_numbered,True,True +2,8,text,"Ceramics, which are non-metallic inorganic biomaterials, have been widely proposed for cell osteogenic differentiation and bone regeneration.[20] Bioactive ceramics, such as CaP ceramics and bioactive","[600.0, 231.0, 1092.0, 695.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,paragraph_title,2.1.1. Hydroxyapatite,"[603.0, 717.0, 763.0, 740.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.1. Hydroxyapatite""]",subsection_heading,0.85,frontmatter_side_zone,support_like,heading_numbered,True,True +2,10,text,"HAP is one of the most extensively used CaP ceramics in bone repair and regeneration because of its similarity to the components of human bone minerals.[27,28] HAP with the capability of osteoconducti","[600.0, 759.0, 1093.0, 1177.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,text,"HAP has some drawbacks compared with other CaP ceramics, including poor mechanical properties and low degradability. Therefore, HAP is often mixed with polymers to yield composite scaffolds with impro","[599.0, 1176.0, 1093.0, 1399.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,13,number,2301283 (2 of 27),"[524.0, 1484.0, 658.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,14,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1486.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,15,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smd.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:/","[1153.0, 30.0, 1172.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 44.0, 345.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[901.0, 36.0, 1097.0, 118.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,2,image,,"[237.0, 157.0, 955.0, 847.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,Figure 1. The schematic diagram of bioactive materials and advanced techniques to regulate the stem cell fate with specific cellular and molecular mechanism for the application of bone tissue engineer,"[97.0, 864.0, 1097.0, 906.0]",figure_caption,0.92,"[""figure_title label: Figure 1. The schematic diagram of bioactive materials and a""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,"biocompatibility, superior mechanical properties and excellent osteoconductivity, both in vitro and in vivo, and scaffolds combined with BMSCs significantly promoted new bone formation. $ ^{[31]} $ Mo","[95.0, 937.0, 588.0, 1161.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,2.1.2. Tricalcium Phosphate,"[98.0, 1202.0, 301.0, 1224.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.2. Tricalcium Phosphate""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,6,text,"HAP with a high crystallinity is relatively difficult to degrade in vivo, whereas TCP is more easily degraded and has a higher solubility. TCP combined with HAP in different proportions within composi","[95.0, 1245.0, 588.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"application in bone scaffolds. By contrast, 𝛽-TCP is more stable. +After degradation, 𝛽-TCP promotes mineralization by releasing +calcium and phosphate ions. Furthermore, 𝛽-TCP displays good +biocompatibi","[605.0, 937.0, 1097.0, 1070.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,β-TCP can be prepared using two methods: high-temperature solid-phase reaction and room-temperature wet method. The high-temperature solid-phase reaction method typically involves mixing CaHPO₄·2H₂O a,"[604.0, 1071.0, 1099.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,10,number,2301283 (3 of 27),"[530.0, 1484.0, 664.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,11,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,12,aside_text,"2369608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smk.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https://","[1153.0, 29.0, 1172.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +4,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[91.0, 45.0, 340.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header,"small methods +www.small-methods.com","[895.0, 36.0, 1092.0, 118.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,figure_title,(A),"[105.0, 155.0, 143.0, 183.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,3,image,,"[121.0, 203.0, 311.0, 374.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,4,figure_title,(B),"[432.0, 151.0, 473.0, 181.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,5,figure_title,(E),"[105.0, 377.0, 142.0, 407.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,6,image,,"[333.0, 204.0, 421.0, 375.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,7,chart,,"[421.0, 200.0, 656.0, 398.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,8,figure_title,(c),"[675.0, 151.0, 715.0, 181.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,9,image,,"[657.0, 179.0, 848.0, 414.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,10,figure_title,(D),"[884.0, 151.0, 923.0, 180.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,11,image,,"[887.0, 186.0, 969.0, 296.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,12,image,,"[973.0, 184.0, 1061.0, 296.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,13,image,,"[886.0, 303.0, 967.0, 411.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,14,image,,"[967.0, 303.0, 1058.0, 412.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,15,image,,"[103.0, 434.0, 607.0, 734.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,16,figure_title,(H),"[660.0, 428.0, 698.0, 458.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (H)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,17,image,,"[618.0, 431.0, 1085.0, 687.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,18,figure_title,(1),"[675.0, 691.0, 703.0, 721.0]",figure_caption_candidate,0.85,"[""figure_title label: (1)""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +4,19,figure_title,(F),"[106.0, 745.0, 140.0, 774.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,20,figure_title,(G),"[425.0, 749.0, 464.0, 778.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (G)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,21,image,,"[124.0, 781.0, 399.0, 1170.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,22,chart,,"[424.0, 801.0, 694.0, 1167.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,23,image,,"[740.0, 696.0, 1020.0, 932.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,24,chart,,"[739.0, 942.0, 1033.0, 1179.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,25,figure_title,Figure 2. A) In vivo bone regeneration efficacy of whitlockite (WH: Ca $ _{18} $Mg $ _{2} $(HPO $ _{4} $) $ _{2} $(PO $ _{4} $) $ _{12} $) embedded 3D cryogel implants after 6 weeks of subcutaneous in,"[90.0, 1187.0, 1094.0, 1361.0]",figure_caption,0.92,"[""figure_title label: Figure 2. A) In vivo bone regeneration efficacy of whitlocki""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +4,26,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,27,number,2301283 (4 of 27),"[524.0, 1484.0, 658.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,28,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,29,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 31.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 46.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header,small methods,"[1003.0, 36.0, 1095.0, 97.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +5,2,header,www.small-methods.com,"[902.0, 97.0, 1096.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,3,text,"purity, while this method also has some disadvantages such as requiring the use of organic solvents, long preparation time, and difficulty in controlling crystal structure. These methods are only part","[95.0, 149.0, 587.0, 281.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"However, $ \beta $-TCP scaffolds are brittle and are often mixed with other biomaterials to counteract the drawback of low tensile strength. The use of porous $ \beta $-TCP scaffolds in bone regener","[95.0, 281.0, 587.0, 501.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,paragraph_title,2.1.3. Biphasic Calcium Phosphate,"[98.0, 543.0, 351.0, 566.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.3. Biphasic Calcium Phosphate""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,6,text,"BCP is a combination of HAP and $ \beta $-TCP, and, as a result, combines the advantages of two calcium phosphates, including the good biocompatibility, osteoconductivity, and osteoinductivity of bot","[95.0, 587.0, 588.0, 917.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,"Nevertheless, BCP has low biological activity, which is not conducive to the proliferation and differentiation of bone cells. In addition, the slow degradation rate of BCP may affect the regeneration ","[96.0, 918.0, 587.0, 1203.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,paragraph_title,2.1.4. Phosphate Bioactive Glasses,"[97.0, 1246.0, 349.0, 1268.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.4. Phosphate Bioactive Glasses""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,9,text,"Different BGs can be fabricated by varying the ratios of calcium oxide, silicate, borate, and phosphorus, and several BGs have been used for bone regeneration. BGs can release bioactive ions that prom","[95.0, 1288.0, 588.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"tion by releasing proangiogenic ions.[41] For example, strontium- +doped BG nanoparticles could enhance osteoblast activity and +induce osteoblasts to generate cytokines associated with vascu- +larizatio","[604.0, 149.0, 1097.0, 302.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,"Mesoporous BGs doped with manganese and silver have been proposed to exhibit antibacterial activity and facilitate wound healing by preventing infection. $ ^{[49,50]} $ Nanostructured BGs with highly ","[605.0, 303.0, 1098.0, 632.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,text,"Among various preparation methods, sol-gel method is a common one, which involves preparing sol, gel, drying, and heat treatment. BGs has good biocompatibility and biodegradability, which can promote ","[605.0, 633.0, 1098.0, 1004.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,text,"In recent years, ceramics has been utilized in various forms, such as coating and scaffold, for bone regeneration due to its unique bioactive properties and effectiveness in promoting bone regeneratio","[604.0, 1004.0, 1099.0, 1313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,14,paragraph_title,2.2. Polymers,"[607.0, 1355.0, 717.0, 1378.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Polymers""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,15,text,"Polymers are easy to manufacture and can be obtained in desirable sizes and shapes. Based on their source, they are","[605.0, 1398.0, 1099.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,16,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,17,footer,2301283 (5 of 27),"[530.0, 1484.0, 665.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,18,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,19,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/snmd.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153.0, 29.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 45.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header_image,,"[997.0, 36.0, 1089.0, 98.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +6,2,header,www.small-methods.com,"[897.0, 98.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,figure_title,Table 1. Summarization of ceramics: advantages and disadvantages.,"[91.0, 149.0, 549.0, 170.0]",table_caption,0.9,"[""table prefix matched: Table 1. Summarization of ceramics: advantages and disadvant""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,4,table,"
Type of ceramicsAdvantagesDisadvantagesReferences
HAPResembles mineral phase of bonePoor mechanical properties<","[90.0, 184.0, 1086.0, 558.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,5,text,"classified as natural or synthetic polymers. Natural polymers such as polysaccharides (chitosan, hyaluronic acid, cellulose, alginate, starch, carrageenan, and gellan gum) and proteins (collagen, gela","[89.0, 609.0, 582.0, 1073.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,paragraph_title,2.2.1. Natural Polymers,"[92.0, 1114.0, 269.0, 1136.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.1. Natural Polymers""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,7,text,Chitosan is made up of glucosamine and N-acetyl glucosamine units that are linked together by $ \beta(1-4) $ glycosidic bonds. Chitosan is a versatile natural polymer derived from the partial deacety,"[89.0, 1157.0, 583.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,"with high stem cell affinity could promote cell proliferation, ad- +hesion, and osteogenesis in vitro and upregulate the expression +of osteogenic markers and alkaline phosphatase (ALP) activity.[57] +Poly","[598.0, 609.0, 1093.0, 982.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"Alginate is a linear polysaccharide that contains β-D-mannuronate (M) and α-L-guluronate (G) residues, which are linked together in a (1, 4) configuration. Alginate extracted from brown seaweed posses","[598.0, 982.0, 1093.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,11,number,2301283 (6 of 27),"[525.0, 1484.0, 658.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,12,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,13,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 30.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +7,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 46.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header,small methods,"[1003.0, 37.0, 1095.0, 97.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +7,2,header,www.small-methods.com,"[902.0, 97.0, 1096.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,3,text,deliver bone-forming peptide-1. $ ^{[63]} $ A thermo-sensitive alginate/ $ \beta $-TCP/aspirin hydrogel with an interconnected porous microstructure fabricated by Fang et al. was implanted into the pe,"[95.0, 149.0, 588.0, 633.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"Hyaluronic acid (HA) is an important component of the ECM in the human body, and its interaction with cluster of differentiation 44 (CD44) may regulate cell motility and adhesion. $ ^{[65]} $ Bioactiv","[96.0, 633.0, 587.0, 1268.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"Collagen is the most abundant protein in bone ECM, and type I collagen is the most ubiquitous among $ \approx $29 types of collagen, especially in bone tissues. $ ^{[70]} $ Collagen is a fibrous prot","[95.0, 1266.0, 588.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"cific mechanical and biological properties. Collagen can be ap- +plied to bone tissue engineering in different physical forms, such +as scaffolds, hydrogels, sponges, films, micro-and nanospheres, +and compo","[604.0, 148.0, 1099.0, 742.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"Gelatin is derived from the degradation of type I collagen. Gelatin has biologically functional arginine–glycine–aspartate-binding sequences that improve cell adhesion, differentiation, and proliferat","[604.0, 742.0, 1098.0, 1311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,Silk fibroin is a sustainable and biocompatible fibrous polymer with high mechanical strength that is suitable for use as a bone biomaterial. The degradation rate of silk fibroin-based biomaterials ca,"[604.0, 1310.0, 1098.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,10,footer,2301283 (7 of 27),"[530.0, 1484.0, 665.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,11,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,12,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smld.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 31.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +8,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header_image,,"[997.0, 37.0, 1089.0, 97.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +8,2,header,www.small-methods.com,"[897.0, 97.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"osteogenesis of silk fibroin limits its application in bone repair, it can promote new bone formation when combined with other biomaterials. For instance, a silk fibroin/chitosan/HAP composite combine","[90.0, 149.0, 582.0, 678.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,2.2.2. Synthetic Polymers,"[92.0, 720.0, 279.0, 743.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.2. Synthetic Polymers""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,5,text,"Polycaprolactone (PCL), polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers are US Food and Drug Administration (FDA) approved polyesters that are extensively used in bone repair and ","[90.0, 763.0, 581.0, 895.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"PLA is characterized by cytocompatibility, non-toxic degradation products, and thermal stability. $ ^{[82,83]} $ Grémare et al. reported that the cell viability and metabolic activity of human bone ma","[89.0, 895.0, 582.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,text,"biodegradation rate and mechanical properties by changing its +structure and morphology, such as its molecular weight and +cross-linking.","[600.0, 149.0, 1091.0, 214.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"PGA has a high tensile modulus and porosity and can be easily manipulated and manufactured into various shapes. $ ^{[88]} $ However, its rapid degradation rate, low mechanical strength, and acidic deg","[598.0, 213.0, 1093.0, 1049.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,text,"PCL is an aliphatic polymer, consisting of hexanoate units, and has high crystallinity, easily manipulable mechanical characteristics, and good biocompatibility. Lin et al. reported that the PCL/cobal","[598.0, 1049.0, 1093.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,11,number,2301283 (8 of 27),"[524.0, 1484.0, 658.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,12,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,13,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 30.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,"small methods +www.small-methods.com","[901.0, 36.0, 1097.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,2,figure_title,(A),"[103.0, 155.0, 137.0, 181.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,3,image,,"[149.0, 158.0, 346.0, 306.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,4,image,,"[340.0, 157.0, 575.0, 315.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,5,image,,"[569.0, 155.0, 834.0, 328.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,image,,"[846.0, 157.0, 1080.0, 351.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,7,image,,"[142.0, 329.0, 826.0, 586.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,8,figure_title,(B),"[850.0, 155.0, 881.0, 180.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,figure_title,(C),"[848.0, 355.0, 879.0, 380.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,10,chart,,"[847.0, 365.0, 1093.0, 577.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,11,figure_title,(D),"[109.0, 596.0, 140.0, 621.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,12,image,,"[128.0, 602.0, 475.0, 849.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,13,figure_title,(F),"[491.0, 607.0, 522.0, 628.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,14,image,,"[483.0, 601.0, 838.0, 766.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,15,figure_title,(G),"[820.0, 599.0, 855.0, 623.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (G)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,16,chart,,"[824.0, 601.0, 1085.0, 775.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,17,figure_title,(H),"[479.0, 762.0, 511.0, 785.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (H)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,18,figure_title,(E),"[117.0, 855.0, 147.0, 879.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,19,image,,"[479.0, 763.0, 820.0, 877.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,20,figure_title,(K),"[839.0, 772.0, 873.0, 795.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (K)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,21,image,,"[126.0, 859.0, 467.0, 1016.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,22,image,,"[836.0, 773.0, 1089.0, 861.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,23,chart,,"[484.0, 884.0, 635.0, 1017.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,24,chart,,"[633.0, 885.0, 824.0, 1017.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,25,image,,"[822.0, 866.0, 1090.0, 1016.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,26,figure_title,"Figure 3. A) Biomimetic melt electrowritten lattice and bioglass particle reinforced hydrogel scaffolds were fabricated. B) The weight percents of Ca, P, and Ca/P ratio for all the scaffolds. C) FTIR ","[94.0, 1025.0, 1101.0, 1160.0]",figure_caption,0.92,"[""figure_title label: Figure 3. A) Biomimetic melt electrowritten lattice and biog""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +9,27,text,"degradation rate and poor hydrophilicity restrict its application in bone tissue engineering. To overcome these shortcomings, PCL can be compounded with other materials, doped and modified. Among them","[95.0, 1200.0, 588.0, 1443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,28,text,"Different kinds of polymeric scaffolds have increasingly been +employed in bone repair and regeneration for the past few years. +Polymeric scaffolds combined with growth factors and stem cells +can modulate","[604.0, 1199.0, 1099.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,29,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,30,number,2301283 (9 of 27),"[530.0, 1484.0, 664.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,31,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1486.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,32,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smll.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1155.0, 32.0, 1171.0, 1536.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +10,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[91.0, 45.0, 338.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header_image,,"[896.0, 36.0, 1092.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +10,2,figure_title,Table 2. Summarization of polymers: advantages and disadvantages.,"[91.0, 149.0, 551.0, 171.0]",table_caption,0.9,"[""table prefix matched: Table 2. Summarization of polymers: advantages and disadvant""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,3,table,"
Type of polymersExamplesAdvantagesDisadvantagesReferences
Natural polymersChitosanResistance to bacter","[91.0, 182.0, 1085.0, 1037.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +10,4,text,"current limitations of polymeric scaffolds in bone repair and regeneration include the possible retention of toxic products resulting from polymer degradation, denaturation of biomolecules bound to th","[90.0, 1091.0, 582.0, 1270.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,paragraph_title,2.3. Metals,"[91.0, 1307.0, 182.0, 1328.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Metals""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,6,text,"Metals with excellent mechanical properties and load-bearing capacities are ideal for bone implantation and cardiovascular stents. Commonly used metallic materials, such as titanium, magnesium, iron, ","[90.0, 1350.0, 582.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,text,"production and processing, mild stretchability, low modulus, +good cytocompatibility, and corrosion resistance.[98] Titanium +and its alloys are the most commonly used metallic materials for +bone-defect","[599.0, 1091.0, 1093.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,9,footer,2301283 (10 of 27),"[520.0, 1484.0, 663.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,10,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,11,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/snml.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153.0, 29.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +11,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 46.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header,small methods,"[1003.0, 36.0, 1095.0, 97.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +11,2,header,www.small-methods.com,"[902.0, 97.0, 1096.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,3,text,"ions released by metal degradation, such as magnesium, iron, zinc, and strontium, have important effects on bone healing by affecting the balance between bone cells and are regarded as biological fact","[95.0, 149.0, 588.0, 610.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,Metal-organic frameworks (MOFs) with intramolecular pores and intrinsic bioactivity comprise metal ions and organic ligands. The large specific surface area of MOFs is conducive to cell adhesion and p,"[95.0, 610.0, 588.0, 1226.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"There are several methods for preparing MOFs, including solvothermal synthesis (mixing metal ions and organic ligands in an organic solvent, heating to a certain temperature, and forming crystals), hy","[95.0, 1223.0, 588.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,"ing metal ions and organic ligands in water and organic solvents, +heating to a certain temperature, and forming crystals). Each of +these methods has its own advantages and disadvantages, and the +speci","[605.0, 149.0, 1099.0, 503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,paragraph_title,2.4. Layered Double Hydroxide,"[607.0, 565.0, 844.0, 588.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Layered Double Hydroxide""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +11,8,text,"Several studies have focused on the application of layered double hydroxide (LDH) in the biomedical field, such as drug/gene delivery, bone repair and regeneration, and biological functional surface m","[604.0, 609.0, 1098.0, 1094.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"Multifunctional layered SrFe₁₂O₁₉-LDH/chitosan scaffolds composed of SrFe₁₂O₁₉ nanoparticles, LDH nanoparticles, and bioactive chitosan can inhibit bone resorption in osteoclasts and the release of pr","[605.0, 1091.0, 1098.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,11,footer,2301283 (11 of 27),"[526.0, 1483.0, 669.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,12,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1486.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,13,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. 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See the Terms and Conditions (https:","[1154.0, 30.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +13,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 46.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,header,small methods,"[1003.0, 36.0, 1096.0, 95.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +13,2,header,www.small-methods.com,"[902.0, 98.0, 1096.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,3,text,"osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities (Figure 5I–L). $ ^{[123]} $","[95.0, 149.0, 586.0, 192.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"The preparation method of LDH has a great influence on its properties. For example, different preparation methods can obtain different layered structures, which can affect its physical and chemical pr","[96.0, 193.0, 588.0, 260.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,text,"chemical properties. Common preparation methods include co- +precipitation, hydrothermal synthesis, ion exchange, etc. In ad- +dition, the preparation method of LDH can also affect its crystal +structure,","[605.0, 149.0, 1098.0, 260.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,6,text,"Figure 4. A) Scheme showing MgGA MOF and PLGA/Mg-GA MOF scaffold preparation. B) ALP staining of hBMSCs in the extracts. C) ARS staining of hBMSCs in the extracts. $ ^{[112]} $ Copyright 2022, Elsevie","[96.0, 319.0, 1099.0, 417.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 4. 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A) ALP staining and ARS staining of Control, Let-7d, LDH and LDH/let-7d groups on day 7 and day 14, respectively. Scale bars: 500 $ \mu $m. B) LDH/let-7d-incorporated fibrin scaffolds promo","[95.0, 1254.0, 1100.0, 1428.0]",figure_caption,0.92,"[""figure_title label: Figure 5. A) ALP staining and ARS staining of Control, Let-7""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +13,40,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,41,number,2301283 (13 of 27),"[526.0, 1484.0, 669.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,42,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1486.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,43,aside_text,"23669608, 2024, 8. Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1147.0, 34.0, 1171.0, 1471.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +14,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 45.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,1,header,small methods,"[997.0, 36.0, 1089.0, 97.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +14,2,header,www.small-methods.com,"[896.0, 96.0, 1090.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,3,paragraph_title,2.5. Composites,"[91.0, 148.0, 219.0, 171.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Composites""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,4,text,"As mentioned above, each material has merits and shortcomings in bone tissue engineering. The main limitations of individual materials are the brittleness and low degradability of ceramics, weak mecha","[89.0, 192.0, 581.0, 391.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,text,"Composite scaffolds have been used to regulate scaffold properties and repair bone defects. Numerous studies have applied ceramic and polymer composites in bone tissue engineering. For example, a chit","[89.0, 392.0, 583.0, 1245.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,"The preparation method affects the mechanical properties, thermal conductivity, heat resistance, and corrosion resistance of composite materials. For example, different preparation methods can control","[89.0, 1244.0, 583.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,text,"als. In summary, the preparation method of composite materials +has an important influence on their properties. Through the de- +velopment of new technical systems, the innovation and develop- +ment of bi","[600.0, 149.0, 1093.0, 326.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,8,paragraph_title,3. 3D printing Scaffolds and External Stimuli-Responsive Biomaterials for Bone Therapeutics and Regeneration,"[601.0, 360.0, 1003.0, 435.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3. 3D printing Scaffolds and External Stimuli-Responsive Bio""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +14,9,text,"Through the development of new technical systems, the innovation and development of biological materials can be promoted, and their performance and effect can be improved. The new technology system ca","[599.0, 447.0, 1093.0, 801.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,10,paragraph_title,3.1. 3D Printing Technology for Bone Tissue Engineering,"[601.0, 835.0, 1029.0, 859.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1. 3D Printing Technology for Bone Tissue Engineering""]",subsection_heading,0.6,body_zone,body_like,none,True,True +14,11,text,Developing 3D printing scaffolds have been used successfully to repair bone defects while effectively accelerating bone regeneration. Composite 3D printing scaffolds possess favorable characteristics ,"[600.0, 879.0, 1093.0, 1165.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,12,paragraph_title,3.1.1. Advances in 3D Printing Technology,"[602.0, 1202.0, 908.0, 1225.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1.1. Advances in 3D Printing Technology""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,13,text,"A large variety of conventional techniques, such as gas foaming, freeze-drying, solvent casting, phase separation, and electrospinning, have been used to manufacture scaffolds for various tissues base","[598.0, 1245.0, 1093.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,14,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,15,footer,2301283 (14 of 27),"[520.0, 1484.0, 663.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +14,16,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1486.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,17,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 30.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +15,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,header,"small methods +www.small-methods.com","[900.0, 36.0, 1097.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,2,figure_title,(A),"[109.0, 152.0, 144.0, 180.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,3,image,,"[109.0, 162.0, 583.0, 282.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,4,figure_title,(B),"[109.0, 278.0, 142.0, 306.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,5,chart,,"[433.0, 168.0, 580.0, 283.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,6,image,,"[152.0, 286.0, 275.0, 400.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,7,chart,,"[431.0, 292.0, 580.0, 403.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,8,figure_title,(a),"[634.0, 181.0, 658.0, 202.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,9,figure_title,(D),"[594.0, 152.0, 628.0, 179.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,10,figure_title,(C),"[108.0, 400.0, 143.0, 428.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,11,chart,,"[161.0, 416.0, 362.0, 561.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,12,chart,,"[381.0, 420.0, 577.0, 561.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,13,image,,"[603.0, 155.0, 1084.0, 524.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,14,chart,,"[164.0, 570.0, 362.0, 716.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,15,chart,,"[381.0, 571.0, 580.0, 715.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,16,image,,"[610.0, 565.0, 762.0, 685.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,17,image,,"[765.0, 567.0, 928.0, 680.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,18,image,,"[933.0, 567.0, 1087.0, 678.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,19,figure_title,(E),"[104.0, 725.0, 139.0, 754.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,20,figure_title,(G),"[475.0, 726.0, 510.0, 753.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (G)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,21,image,,"[135.0, 750.0, 454.0, 912.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,22,figure_title,(F),"[105.0, 911.0, 136.0, 940.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,23,image,,"[130.0, 915.0, 459.0, 1078.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,24,image,,"[486.0, 732.0, 1084.0, 1086.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,25,figure_title,"Figure 6. A,B) SEM image of scaffolds after soaking in SBF for 5 days (A1, A2: MBG/SF scaffold; B1, B2: MBG/PCL scaffold) and EDS spectra (A3: MBG/SF scaffold; B3:MBG/PCL scaffold). C) The relative ex","[95.0, 1098.0, 1100.0, 1252.0]",figure_caption,0.92,"[""figure_title label: Figure 6. A,B) SEM image of scaffolds after soaking in SBF f""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +15,26,text,"mesoporous bioactive glass (MBG) to fabricate MBG/SF composite scaffolds by 3D printing, and the results revealed that the gene expression levels of common osteogenic biomarkers on MBG/SF scaffolds we","[95.0, 1288.0, 587.0, 1399.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,27,text,3D printing combined with 3D computer imaging and calculation software can be used to fabricate tailored implants with complex 3D structures for patients with bone tissue defects. $ ^{[135]} $ Precise,"[96.0, 1399.0, 588.0, 1443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,28,text,"plex 3D structures for patients with bone tissue defects.[135] Pre- +cise control of the bulk geometry and internal structure of scaf- +folds is a major advantage of 3D printing technology in bone engi-","[604.0, 1288.0, 1099.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,29,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,30,number,2301283 (15 of 27),"[526.0, 1483.0, 668.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +15,31,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1486.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,32,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 31.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +16,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,1,header_image,,"[997.0, 36.0, 1089.0, 97.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +16,2,header,www.small-methods.com,"[897.0, 98.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,3,text,"architecture of native bone. $ ^{[136]} $ In addition, several 3D bioprinting techniques, such as inkjet, extrusion, and laser-assisted bioprinting, have been developed in regenerative medicine, which","[90.0, 149.0, 582.0, 436.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,4,paragraph_title,3.1.2. The Basic Requirements of Bone Scaffolds,"[91.0, 479.0, 439.0, 502.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1.2. The Basic Requirements of Bone Scaffolds""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +16,5,text,"The mechanical integrity, microstructure, biocompatibility, biodegradability, and osteoconductivity are crucial properties of scaffolds for bone repair and regeneration, and it is essential to achieve","[90.0, 521.0, 582.0, 1115.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,text,"Postprint modification is often applied to improve the performance of bone scaffolds and obtain the desired effect. Such modifications can promote stem cell proliferation and differentiation, and impr","[89.0, 1114.0, 583.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,7,text,"10–50 μm, were used as the initial printing materials in the print- +ing ink formulations (Figure 6D).[32]","[601.0, 148.0, 1091.0, 195.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,8,paragraph_title,3.1.3. 3D-Printed Scaffolds for Bone Repair,"[602.0, 238.0, 913.0, 260.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1.3. 3D-Printed Scaffolds for Bone Repair""]",subsection_heading,0.6,body_zone,body_like,none,True,True +16,9,text,"Composites can combine the merits of two or more different types of materials and thus meet the performance requirements of bone scaffolds to a large extent, including mechanical and biological proper","[598.0, 281.0, 1093.0, 1158.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,10,text,"In recent years, increasing researchers have applied 3D printing technology to bone tissue regeneration. Polymer materials and hydrogel materials have their own advantages and disadvantages in bone re","[598.0, 1158.0, 1093.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,11,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,12,footer,2301283 (16 of 27),"[520.0, 1484.0, 663.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +16,13,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,14,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/snmd.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153.0, 29.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +17,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 44.0, 345.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,1,header,"small methods +www.small-methods.com","[901.0, 36.0, 1097.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,2,figure_title,Table 3. Summarization of physical stimuli-responsive strategies: advantages and disadvantages.,"[97.0, 149.0, 743.0, 171.0]",table_caption,0.9,"[""table prefix matched: Table 3. Summarization of physical stimuli-responsive strate""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +17,3,table,
Type of physical stimuli-responsive strategiesAdvantagesDisadvantagesReferences.
Photoresponsive strategyNoninvasive with high contr,"[97.0, 183.0, 1092.0, 577.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +17,4,text,"preparation of high-quality tantalum implants, and exploration of breakthrough directions in bone tissue engineering printing technology.","[95.0, 631.0, 587.0, 698.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,5,paragraph_title,3.2. Physical Stimuli-Responsive Bone Therapy and Regeneration,"[96.0, 730.0, 585.0, 753.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Physical Stimuli-Responsive Bone Therapy and Regenerati""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +17,6,text,"Numerous strategies have been developed to manufacture physical stimuli-responsive materials for bone-tissue engineering. External physical stimuli, including light, magnetic and electric fields, ultr","[95.0, 773.0, 588.0, 996.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,paragraph_title,3.2.1. Photoresponsive Strategy,"[98.0, 1027.0, 326.0, 1049.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.1. Photoresponsive Strategy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +17,8,text,"Photoresponsive materials can be activated by externally applied optical signals and generate photophysical effects, subsequently affecting intracellular behavior and the respiratory chain, facilitati","[96.0, 1071.0, 588.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,9,text,"Sr2+ by flawing the PLGA shells, ultimately promoting bone re- +generation in rat femoral defect models.[148] Under 808-nm near- +infrared light irradiation, HAP/graphene oxide/chitosan scaf- +folds with ","[605.0, 630.0, 1098.0, 876.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,10,paragraph_title,3.2.2. Electroresponsive Strategy,"[609.0, 917.0, 842.0, 940.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.2. Electroresponsive Strategy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +17,11,text,Previous studies have shown that electrical stimuli can enhance bone regeneration and maintain the stemness of bone marrow MSCs. The mechanism of this effect is related to the stimulation of MSC proli,"[605.0, 961.0, 1099.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,12,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,13,number,2301283 (17 of 27),"[526.0, 1484.0, 669.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +17,14,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,15,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 30.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +18,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +18,1,header,small methods,"[997.0, 36.0, 1089.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +18,2,header,www.small-methods.com,"[897.0, 97.0, 1090.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +18,3,text,"was applied, titanium sheets coated with polyaniline (poly(amide-amine) dendrimer) @ Ag layer exhibited excellent antibacterial properties and improved osteogenic differentiation compared with pure ti","[90.0, 148.0, 581.0, 436.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,4,paragraph_title,3.2.3. Magnetic-Responsive Strategy,"[92.0, 478.0, 354.0, 501.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.3. Magnetic-Responsive Strategy""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +18,5,text,Magnetic-responsive materials are composed of ferromagnetic or paramagnetic nanoparticles that can be manipulated by magnetic fields and act as therapeutic agents for magnetic hyperthermia. Magnetic n,"[89.0, 519.0, 583.0, 1315.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,6,paragraph_title,3.2.4. Ultrasound-Responsive Strategy,"[92.0, 1355.0, 367.0, 1379.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.4. Ultrasound-Responsive Strategy""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +18,7,text,"Ultrasound has been shown to promote bone regeneration by increasing the mRNA expression of VEGF-A and stimulating the proliferation of chondrocytes, thereby facilitating the formation of new bone and","[90.0, 1398.0, 582.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,8,text,"the proliferation of chondrocytes, thereby facilitating the for- +mation of new bone and cell mineralization (Figure 7A–C).[158] +Nanocomplexes can be triggered by nonthermal clinical diag- +nostic ultra","[600.0, 149.0, 1093.0, 545.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,9,paragraph_title,3.2.5. Piezoelectricity-Responsive Strategy,"[602.0, 588.0, 902.0, 611.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.5. Piezoelectricity-Responsive Strategy""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +18,10,text,Natural bone tissues exhibit bioelectrical properties that are essential for bone development. Piezoelectricity is the conversion of mechanical energy into electrical energy. Under physiological condi,"[598.0, 632.0, 1094.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,11,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,12,footer,2301283 (18 of 27),"[520.0, 1484.0, 663.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +18,13,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,14,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkl.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153.0, 22.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,body_like,none,False,False +19,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 44.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +19,1,header_image,,"[900.0, 35.0, 1097.0, 117.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +19,2,image,,"[103.0, 150.0, 1085.0, 821.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +19,3,figure_title,"Figure 7. A,B) Water contact angle measurement for the Ti6Al4V substrate (A1) and Ti6Al4V substrate with BaTiO₃ coating (B1); Surface CLSM images of the Ti6Al4V substrate (A2) and Ti6Al4V substrate wi","[95.0, 836.0, 1100.0, 954.0]",figure_caption,0.92,"[""figure_title label: Figure 7. A,B) Water contact angle measurement for the Ti6Al""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +19,4,text,Piezo1 by fabricating a wearable pulsed triboelectric nanogenerator (WP-TENG) driven by human body movement (Figure 7D). $ ^{[16]} $ Epigallocatechin gallate (EGCG) was loaded into gold nanoparticle-m,"[95.0, 981.0, 587.0, 1113.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,5,text,"Physical stimuli-responsive strategies lack controllability, predictability, feasibility, and standardization in bone repair and regeneration applications according to existing research. These materia","[95.0, 1113.0, 589.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,6,text,"cross-fusion is also an inevitable trend in the clinical develop- +ment of orthopedics. Therefore, future research will focus on +developing better materials to promote bone tissue regeneration +and func","[604.0, 981.0, 1099.0, 1071.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,7,paragraph_title,4. The Underlying Mechanism of Bioactive Materials for Bone Regeneration,"[606.0, 1115.0, 1017.0, 1166.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. The Underlying Mechanism of Bioactive Materials for Bone ""]",section_heading,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +19,8,text,Understanding the molecular mechanism of bioactive materials on bone tissue can improve the design and preparation of materials to better promote bone regeneration. By studying the molecular mechanism,"[605.0, 1179.0, 1099.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,9,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,10,number,2301283 (19 of 27),"[526.0, 1484.0, 669.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +19,11,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1486.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,12,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 31.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,body_like,none,False,False +20,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[93.0, 45.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +20,1,header,small methods,"[997.0, 36.0, 1089.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,2,header,www.small-methods.com,"[897.0, 97.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +20,3,paragraph_title,4.1. Regulation of Stem Cells by Biomaterials,"[91.0, 149.0, 432.0, 171.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.1. Regulation of Stem Cells by Biomaterials""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,4,text,Stem cells are undifferentiated cells that self-renew and produce an abundance of undifferentiated offspring. They have strong proliferative capacity and multi-lineage differentiation ability; therefo,"[90.0, 192.0, 582.0, 565.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,5,text,"Bone biomaterials act as platforms to facilitate stem cell adhesion and growth during bone repair. The chemical components, surface characteristics, and topographic structure of bone biomaterials dire","[90.0, 566.0, 582.0, 1073.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,6,paragraph_title,4.2. Biomaterial-Induced Pathway Modulation for Bone Regeneration,"[91.0, 1102.0, 506.0, 1148.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2. Biomaterial-Induced Pathway Modulation for Bone Regener""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,7,text,"Several signaling pathways and transcription factors have been shown to regulate the osteogenic differentiation of stem cells. To develop novel strategies for bone repair and regeneration, it is neces","[90.0, 1168.0, 581.0, 1302.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,8,paragraph_title,4.2.1. BMP Signaling Pathway,"[92.0, 1334.0, 317.0, 1357.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.1. BMP Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,9,text,BMPs belong to the TGF- $ \beta $ superfamily and are of great importance in bone formation and tissue homeostasis. This signaling is initiated by the binding of BMP to BMP receptors on the cell membr,"[90.0, 1376.0, 582.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,10,text,"the cell membrane, and the downstream Smad proteins are then +phosphorylated by activated receptors. Smad complexes translo- +cate into the nucleus, activating osteogenesis-related transcrip- +tion facto","[600.0, 150.0, 1093.0, 700.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,11,paragraph_title,4.2.2. Wnt Signaling Pathway,"[603.0, 720.0, 821.0, 743.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.2. Wnt Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,12,text,The Wnt/ $ \beta $-catenin signaling pathway is recognized as a crucial signal for the regulation of stem cell osteogenic differentiation and is strongly associated with the formation and regeneration,"[600.0, 762.0, 1093.0, 1336.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,13,paragraph_title,4.2.3. Notch Signaling Pathway,"[602.0, 1355.0, 836.0, 1379.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.3. Notch Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,14,text,"Notch signaling is a highly persistent pathway associated with cell signal transduction, self-renewal potential and proliferation,","[600.0, 1398.0, 1092.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,15,footer,"Small Methods 2024, 8, 2301283","[94.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,16,footer,2301283 (20 of 27),"[520.0, 1484.0, 663.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +20,17,footer,© 2024 Wiley-VCH GmbH,"[932.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,18,aside_text,"2369608, 2024, 8, Downloaded from https://ontinelibrary.wiley.com/doi/10.1002/smid.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:/","[1154.0, 29.0, 1172.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +21,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 346.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +21,1,header,"small methods +www.small-methods.com","[901.0, 36.0, 1097.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +21,2,figure_title,(A),"[105.0, 163.0, 133.0, 187.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,3,image,,"[106.0, 156.0, 654.0, 485.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,4,figure_title,(C),"[106.0, 500.0, 135.0, 524.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,5,image,,"[671.0, 160.0, 1088.0, 478.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,6,chart,,"[279.0, 515.0, 419.0, 651.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,7,chart,,"[419.0, 514.0, 576.0, 650.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,8,figure_title,(D),"[559.0, 493.0, 587.0, 515.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,9,chart,,"[127.0, 655.0, 273.0, 796.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,10,chart,,"[273.0, 658.0, 419.0, 793.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,11,chart,,"[420.0, 658.0, 563.0, 793.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,12,image,,"[594.0, 499.0, 1079.0, 834.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,13,figure_title,(E),"[105.0, 819.0, 133.0, 842.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,14,image,,"[112.0, 818.0, 587.0, 1200.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,15,figure_title,(F),"[588.0, 852.0, 614.0, 875.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,16,image,,"[630.0, 859.0, 1043.0, 1192.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,17,figure_title,Figure 8. A) Schematic illustration of the procedure to fabricate BP@BMP2 electrospun fibrous scaffolds and the effect of recruiting osteoblasts and releasing calcium-free phosphate therapy for promot,"[96.0, 1216.0, 1100.0, 1353.0]",figure_caption,0.92,"[""figure_title label: Figure 8. A) Schematic illustration of the procedure to fabr""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +21,18,footer,"Small Methods 2024, 8, 2301283","[99.0, 1487.0, 289.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,19,number,2301283 (21 of 27),"[526.0, 1484.0, 668.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +21,20,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,21,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smld.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 31.0, 1172.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +22,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +22,1,header_image,,"[997.0, 36.0, 1089.0, 97.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +22,2,header,www.small-methods.com,"[897.0, 97.0, 1090.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +22,3,text,"and skeletal development. Upon cell-cell contact, Notch ligands (Jagged and Delta) interact with Notch receptors (Notch1–4), leading to the cleavage of the Notch intracellular domain. Subsequently, th","[89.0, 148.0, 583.0, 701.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,4,paragraph_title,4.2.4. MAPK Signaling Pathway,"[92.0, 742.0, 327.0, 765.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.4. MAPK Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +22,5,text,"The mitogen-activated protein kinase (MAPK) family comprises extracellular regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), which are associated with signal transduction in osteoblasts.","[89.0, 784.0, 582.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,6,paragraph_title,4.2.5. Other Osteogenesis-Relevant Signaling Pathways,"[602.0, 148.0, 1001.0, 172.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.5. Other Osteogenesis-Relevant Signaling Pathways""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +22,7,text,"In addition to the aforementioned pathways, bone development and homeostasis involve several other pathways that play an indispensable role in the osteogenic differentiation of undifferentiated and os","[599.0, 192.0, 1093.0, 524.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,8,paragraph_title,5. Conclusions and Outlook,"[602.0, 548.0, 873.0, 574.0]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions and Outlook""]",section_heading,0.85,,heading_like,heading_numbered,True,True +22,9,text,"Herein, we summarized several biomaterials with unique biofunctions, bioactive compounds, 3D bioprinting techniques, and physical stimuli-responsive strategies for bone repair and regeneration. Among ","[600.0, 588.0, 1093.0, 961.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,10,text,"3D printing technology is a novel strategy in precision medicine that can produce bone implants using multiple materials based on digital models. With advances in 3D printing technology, novel composi","[598.0, 961.0, 1094.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,11,footer,"Small Methods 2024, 8, 2301283","[93.0, 1487.0, 283.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +22,12,footer,2301283 (22 of 27),"[520.0, 1484.0, 663.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +22,13,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +22,14,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154.0, 30.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,body_like,none,False,False +23,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 46.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +23,1,header_image,,"[1003.0, 36.0, 1095.0, 95.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +23,2,header,www.small-methods.com,"[903.0, 98.0, 1096.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +23,3,text,"osteogenic substances to stimulate cell growth and differentiation, ultimately improving bone regeneration. These advanced strategies will play crucial roles in precise and efficient bone-tissue repai","[96.0, 149.0, 587.0, 236.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,4,text,"Despite the promising results presented herein, the literature primarily focuses on the development of scaffolds using advanced biomaterials, but lacks sufficient researches on the use of biomaterial-","[96.0, 237.0, 587.0, 479.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,5,paragraph_title,Acknowledgements,"[97.0, 524.0, 289.0, 549.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +23,6,text,"Y.B. and Z.W. contributed equally to this work. This work was financially supported by the National Science Fund for Distinguished Young Scholars (grant no. 82225027), the National Key Research and De","[97.0, 560.0, 587.0, 715.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,7,paragraph_title,Conflict of Interest,"[97.0, 759.0, 281.0, 784.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +23,8,text,The authors declare no conflict of interest.,"[97.0, 797.0, 382.0, 817.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +23,9,paragraph_title,Keywords,"[98.0, 863.0, 196.0, 888.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Keywords""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +23,10,text,"advanced techniques, bioactive materials, bone regeneration, molecular mechanism, stem cells","[97.0, 900.0, 586.0, 940.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,11,text,"Received: September 22, 2023 +Revised: November 4, 2023 +Published online: March 21, 2024","[360.0, 963.0, 586.0, 1020.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +23,12,reference_content,"[1] V. 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"annotated_pages/page_016.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_022.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_036.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:6", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p2:0", + "p2:1", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:8" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/2UIPV93M/audit_report.md b/audit/2UIPV93M/audit_report.md new file mode 100644 index 00000000..2d003f8b --- /dev/null +++ b/audit/2UIPV93M/audit_report.md @@ -0,0 +1,21 @@ +# OCR Truth Audit Report - 2UIPV93M + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 5, 6, 10, 13, 14, 16, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 36, 49, 58] +- Reviewed blocks: 264 + +## Findings + +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/2UIPV93M/audit_scope.json b/audit/2UIPV93M/audit_scope.json new file mode 100644 index 00000000..1417f716 --- /dev/null +++ b/audit/2UIPV93M/audit_scope.json @@ -0,0 +1,1840 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 5, + 6, + 10, + 13, + 14, + 16, + 17, + 18, + 19, + 20, + 22, + 23, + 24, + 25, + 26, + 27, + 28, + 29, + 30, + 31, + 32, + 33, + 36, + 49, + 58 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:8", + "p5:2", + "p6:1", + 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英文缩写英文全称中文全称
THATotal Hip Arthroplasty全髋关节置换术
AIArtificial Intelligence人工智能
CT0.05)。影像学测量结果显示两组术后髋臼假体外展角比较无统计学意义(P>0.05),术后股骨柄-髓腔轴线夹角比较无统计学意义(P>0.05),术后股骨柄-髓腔比差异有统计学意义(P<0.05)。AI组和2D组术前术后双下肢长度比较差异明,"[174.0, 930.0, 1017.0, 1526.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +6,5,number,||,"[587.0, 1565.0, 604.0, 1585.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +6,6,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 385.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +7,0,header,海南医学院硕士学位论文,"[492.0, 86.0, 697.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +7,1,abstract,【结论】:AIHIP 系统可对 THA 手术实现精准规划,与二维数字化模板相比,具有更高的精确性和有效性,可辅助术者在 THA 手术中缩短手术时间,减少术中出血量,促进患者术后髋关节功能恢复。,"[179.0, 150.0, 1012.0, 276.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +7,2,text,关键词:全髋关节置换术;人工智能;术前规划,"[178.0, 377.0, 688.0, 407.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +7,3,number,Ⅲ,"[587.0, 1566.0, 604.0, 1584.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +7,4,footer,中国知网 https://www.cnki.net,"[38.0, 1622.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +8,1,doc_title,"Clinical application research of artificial intelligence +assisted decision-making system in hip replacement","[187.0, 216.0, 1001.0, 323.0]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,,unknown_like,none,False,True +8,2,paragraph_title,ABSTRACT,"[516.0, 465.0, 676.0, 504.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,,heading_like,short_fragment,True,True +8,3,abstract,"[Objective]: To compare the preoperative planning with the two-dimensional digital template (TDTD), and investigate the accuracy and effectiveness of Artificial intelligence system (AIS) in the clinic","[174.0, 584.0, 1011.0, 746.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +8,4,abstract,"[Methods]: From June 2020 to December 2022, a prospective study was conducted on 100 patients who needed primary total hip replacement due to hip joint disease, and patients who met the inclusion crit","[174.0, 761.0, 1011.0, 1173.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +8,5,abstract,"[Results]: All patients were followed up for 6 months, and the incisions healed by first intention. There was no significant difference in general data such as surgical site, age, gender, body mass in","[173.0, 1188.0, 1012.0, 1514.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +8,6,number,IV,"[585.0, 1565.0, 607.0, 1585.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +8,7,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +9,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +9,1,abstract,"difference in the length of the lower limbs between the AI group and the 2D group before and after operation, both of which were statistically significant (P<0.05). The accuracy rates of acetabular pr","[175.0, 141.0, 1011.0, 675.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +9,2,abstract,"[Conclusion]: The AIHIP system can achieve precise planning for THA surgery. Compared with the two-dimensional digital template, it has higher accuracy and effectiveness. It can assist the operator to","[174.0, 695.0, 1011.0, 894.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +9,3,text,Keywords: total hip replacement; artificial intelligence; preoperative planning,"[177.0, 1011.0, 932.0, 1042.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,False,False +9,4,number,V,"[587.0, 1565.0, 603.0, 1583.0]",figure_inner_text,0.9,"[""panel label / figure inner text: V""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,5,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +10,0,paragraph_title,前言,"[557.0, 151.0, 631.0, 194.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u524d\u8a00""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,1,abstract,全髋关节置换术(Total hip arthroplasty,THA)是二十世纪外科手术中最成功的可重复和频繁进行的手术方式之一 $ ^{[1]} $。全髋关节置换术是治疗髋关节畸形、骨关节炎、股骨颈骨折、股骨头坏死、先天性髋关节畸形等髋关节病的有效方法之一 $ ^{[2]} $。由于髋是一种有着独特的解剖学及生物机械特性的复合关节,所以很难对其进行完整的关节活动及受力状态的恢复。2021年美国关,"[175.0, 212.0, 1017.0, 621.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,2,abstract,我国人口结构同样逐渐趋于老龄化,老年髋部骨折发病率逐年增高,此疾病给社会和家庭带来沉重的负担,老年髋部骨折由于其死亡率高,常被称为“人生最后一次骨折”。保守治疗容易引起严重的并发症,比如:坠积性肺炎,臀部压疮,深静脉血栓及肺栓塞,泌尿系统感染,肌肉萎缩等,还会导致原有疾病加重。所以,只要没有明确的外科禁忌证,高龄患者应该尽早进行髋关节的外科治疗。在中国,股骨颈骨折是最常见的髋部骨折,发病率约占全身,"[174.0, 634.0, 1017.0, 994.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,3,abstract,老年股骨颈骨折患者由于严重骨质疏松、骨皮质变薄,为了防止术中骨折,要求手术操作更加小心,良好的术前规划尤为重要。然而骨科医生并没有一个很好的术前计划工具,这导致了术前准备不充分,手术效果多依赖医师经验,髋关节置换手术效果受到严重制约,手术存在较多并发症。目前国内术前规划仍普遍以 X 线胶片模板测量的方式进行,因 X 线胶片放大率不准确 $ ^{[8]} $、拍摄投照角度存在差异 $ ^{[9]} ,"[174.0, 1009.0, 1017.0, 1417.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,4,abstract,在 THA 术前规划领域,X 线平片模板测量及二维术前规划软件出现较早,X 线平片模板测量工具与各类型假体配套,二维术前规划软件则主要包括有,"[173.0, 1429.0, 1013.0, 1510.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,5,number,1,"[587.0, 1565.0, 603.0, 1584.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +10,6,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +11,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +11,1,text,mediCAD(德国,HECTEC Company)、Orthoview(比利时,Materialize Company)等。这种类型的二维术前规划虽在一定程度上提高了THA手术的准确度 $ ^{[13]} $,但由于二维影像无法完整反映三维信息,且全程需要手工标定,操作繁琐,要求规划者具有丰富的临床经验,规划可重复性低,尤其对于复杂髋关节疾病手术而言,其可提供的参考作用较小。近年来,为解决二维术,"[175.0, 153.0, 1017.0, 840.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +11,2,text,各项研究表明,人工智能基于医疗图像进行深度学习的技术在临床应用方面具有广阔的前景,加之髋关节病变主要表现为骨性结构的改变,各类相关疾病 CT 图像特征明显,AI 深度神经网络可以模拟人类视觉感知机理,实现有监督与无监督两种类型的视觉感知,其隐藏层中的卷积核群具有共同的参数以及分层的稀疏特性,可以实现格点化的图像(Grid-like topology)的稳健辨识 $ ^{[17]} $,特别适合于对,"[175.0, 854.0, 1016.0, 1120.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +11,3,text,在手术中导航时,除了只有极个别的医院装备了机器人,绝大部分 THA 由术者依靠个人经验和粗略测量来实现,这会极大的提高患者的风险。有经验的外科医生也许能达到很好的手术效果,但是年轻而缺乏经验的外科医生不一定能用经验的方法获得理想的手术结果,甚至会使术后并发症发生率升高 $ ^{[18]} $。,"[177.0, 1136.0, 1015.0, 1307.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +11,4,abstract,因此本研究将海南医学院第一附属医院关节外科于2020年6月至2022年12月收治的100例拟行单侧初次THA治疗的膝骨关节炎患者随机分组,目的在于探讨与成熟的二维数字模板术前规划方式相比,AI在实现精准THA的有效性以及临床适用性。本研究的假设是AIHIP系统的术前计划是比传统的二维手动,"[178.0, 1322.0, 1016.0, 1494.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +11,5,number,2,"[588.0, 1520.0, 603.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +11,6,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +12,0,header,海南医学院硕士学位论文,"[492.0, 86.0, 697.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +12,1,text,模板更准确地预测假体尺寸和假体位置安放的技术。,"[177.0, 152.0, 723.0, 181.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +12,2,number,3,"[588.0, 1521.0, 602.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +12,3,footer,中国知网 https://www.cnki.net,"[38.0, 1622.0, 384.0, 1649.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +13,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 109.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +13,1,paragraph_title,1 资料与方法,"[176.0, 154.0, 359.0, 193.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1 \u8d44\u6599\u4e0e\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +13,2,paragraph_title,1.1 纳入与排除标准,"[175.0, 226.0, 447.0, 265.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1 \u7eb3\u5165\u4e0e\u6392\u9664\u6807\u51c6""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,3,text,(1) 纳入标准:,"[186.0, 284.0, 354.0, 317.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,reference_like,reference_numeric_parenthesis,False,True +13,4,text,① 患者具有髋关节置换手术适应证;,"[219.0, 329.0, 629.0, 365.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,5,text,② 首次进行髋关节置换的患者;,"[220.0, 376.0, 582.0, 412.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,6,text,③术前患者自愿签署知情同意书;,"[220.0, 423.0, 605.0, 459.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,7,text,④ 影像学资料完整;,"[221.0, 470.0, 462.0, 505.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,8,text,(2) 受试者排除标准;,"[188.0, 518.0, 425.0, 552.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,reference_like,reference_numeric_parenthesis,False,True +13,9,text,① 患者出现了肌萎缩、肌溶解或外展肌乏力等症状;,"[219.0, 563.0, 797.0, 600.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,10,text,② 患者有智力障碍或无法了解参加试验的必要性;,"[220.0, 611.0, 774.0, 646.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,11,text,③ 患者有吸毒史、酗酒史、滥用药物史;,"[220.0, 657.0, 678.0, 692.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,12,text,④ 肥胖 BMI > 35kg/m²;,"[221.0, 704.0, 500.0, 740.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,13,text,⑤ 糖尿病控制不佳(经药物控制空腹血糖仍 $ \geq $8.0mmol/L);,"[220.0, 752.0, 882.0, 786.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,14,text,⑥ 严重的肝肾功能不全,其标准是:谷丙转氨酶(ALT)或谷草转氨酶,"[219.0, 798.0, 1015.0, 833.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,15,text,(AST)超过了其极限 2.5 倍,且血浆肌酐超过了其极限值;,"[187.0, 845.0, 814.0, 879.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,16,text,⑦ 已知患者有内植物过敏史;,"[220.0, 892.0, 557.0, 927.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,17,text,⑧ 髋关节或身体其他部位存在活动性感染病灶;,"[220.0, 939.0, 749.0, 974.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,18,text,⑨ 组成髋关节的骨盆、股骨近端发现有严重的骨质破坏、肿瘤或其他疾病导致的骨性结构受损的病变。,"[174.0, 986.0, 1014.0, 1066.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,19,text,⑩ 孕妇或哺乳期妇女或 12 个月内计划妊娠的妇女;,"[220.0, 1079.0, 797.0, 1114.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,20,text,① 全身性疾病(包括凝血系统异常,心血管疾病,呼吸道疾病以及其他不适合进行麻醉或外科治疗的患者);体质虚弱或由于其他系统性的原因而无法接受外科治疗,平均生存时间少于2年的患者;,"[173.0, 1126.0, 1015.0, 1254.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,21,text,①患者对手术和手术后的诊疗操作不合作或不适应,预期的依从性较低。,"[220.0, 1265.0, 1013.0, 1300.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,22,text,①3 患者既往有髋关节手术史。,"[221.0, 1312.0, 560.0, 1348.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,23,footer,中国知网 https://www.cnki.net,"[37.0, 1620.0, 385.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +13,24,number,4,"[587.0, 1520.0, 603.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,1,paragraph_title,1.2 一般资料,"[177.0, 156.0, 365.0, 191.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2 \u4e00\u822c\u8d44\u6599""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +14,2,text,本研究选取 2020 年 6 月至 2022 年 12 月期间来我院关节外科相同诊疗组因髋关节疾病需行初次全髋关节置换患者进行前瞻性研究。根据纳入标准及排除标准,本研究共纳入患者 100 例(100 髋),按照随机数表法将患者分为 AI 组 50 例(50 髋)和 2D 组(50 髋),其中 AI 组男性 24 例,女性 26 例,左侧髋关节 21 例,右侧髋关节 29 例,平均年龄 $ 56.,"[174.0, 225.0, 1015.0, 675.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,3,paragraph_title,1.3 主要设备,"[177.0, 778.0, 364.0, 813.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.3 \u4e3b\u8981\u8bbe\u5907""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +14,4,text,(1) 硬件:DR 数字 X 射线照相装置(荷兰飞利浦公司),64 排多层螺旋 CT 机(荷兰飞利浦公司),华为手机 p40(中国);,"[176.0, 845.0, 1013.0, 924.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +14,5,text,(2) 软件:AI HIP System(北京长木谷医疗科技有限公司,中国北京),Smart joint 软件(北京长木谷医疗科技有限公司,中国北京),PACS 影像系统(GE 医疗,美国);,"[177.0, 949.0, 1015.0, 1073.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +14,6,text,(3) 其他:标准硬币直径 25mm,U 盘(SanDick)256G;,"[177.0, 1100.0, 773.0, 1130.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +14,7,paragraph_title,1.4 数据获取 1.4.1 影像学数据拍摄,"[176.0, 1218.0, 417.0, 1307.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.4 \u6570\u636e\u83b7\u53d6 1.4.1 \u5f71\u50cf\u5b66\u6570\u636e\u62cd\u6444""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +14,8,footer,,"[176.0, 1277.0, 417.0, 1307.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +14,9,text,(1)CT 扫描标准 $ ^{[19]} $:使用 64 排螺旋 CT 对所有患者髋部进行薄层扫描,取仰卧位,嘱患者手臂上举,双侧大腿内旋,两足尖并拢,身体置于床面中间。扫描层厚:1mm,无间隙、无重叠。扫描范围为髂前下棘至股骨上 1/3,横向切片 1:1 节距,使用螺旋(螺线)扫描。扫描视野:300—400mm,管电压:120kVp,,"[176.0, 1326.0, 1014.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +14,10,number,5,"[588.0, 1520.0, 603.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,11,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +15,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,1,text,管电流 200—250mA;扫描速度:1 秒/圈,层厚:1mm,导出图像为 DICOM 格式。,"[175.0, 151.0, 1012.0, 230.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,2,text,(2)X 线摄片标准 $ ^{[20]} $:受检者身体垂直平卧于摄影台上,两下肢伸直且两足尖并拢,双足稍内旋 10° -15°;放射范围及检测仪的上缘为髂骨嵴,下缘要求至耻骨联合下 3cm;放射源到图像的间距是 100 厘米;中线对齐于双髂前上棘连接的中点向下 3 cm,并竖直射击至检测器中央。图像要求:髋关节正位片范围包括骨盆上缘至股骨近端 1/3,左右对称。两个大粗隆的内侧边缘只有 1/2 ,"[176.0, 255.0, 1014.0, 567.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,3,paragraph_title,1.4.2 影像学测量参数,"[176.0, 641.0, 417.0, 671.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.4.2 \u5f71\u50cf\u5b66\u6d4b\u91cf\u53c2\u6570""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +15,4,text,(1)下肢长度差异:以坐骨结节下边为参照点,在正常的髋关节正位摄影条件下,测定两个坐骨结节下边与两个坐骨结节连边之间的竖直距离。将双下肢差异大于1cm定义为双下肢不等长。,"[176.0, 689.0, 1013.0, 815.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,5,text,(2)髋臼假体外展角:标准髋关节正位片上,用髋臼假体上外侧和内侧两个端部间的连线和基准线之间的角度,在标准正位下,以两侧的坐骨结节下边缘连线作为基准线,测定髋臼上外侧和内侧两个端部间的角度,即为髋臼假体外展角。,"[175.0, 840.0, 1014.0, 1012.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,6,text,(3)股骨柄-髓腔轴线夹角:通过髋关节正位片,测量假体柄的长轴与股骨长轴间夹角,股骨柄-髓腔轴线夹角小于等于3°为股骨柄中央固定,股骨柄-髓腔轴线夹角大于3°则为内翻固定或外翻固定。,"[176.0, 1037.0, 1012.0, 1163.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,7,text,(4)股骨柄-髓腔比:髋关节正位片上,以股骨小转子上缘、股骨柄假体纵向中点、股骨柄下缘尖端上1cm三处为测量平面,计算股骨柄占髓腔比例,最后以百分比表示。,"[178.0, 1188.0, 1014.0, 1311.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,8,number,6,"[587.0, 1520.0, 603.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,9,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +16,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 109.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +16,1,paragraph_title,2 研究方法,"[175.0, 156.0, 328.0, 192.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2 \u7814\u7a76\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +16,2,text,2020 年 6 月至 2022 年 8 月期间,为本院关节外科相同诊疗组中每位首次接受全髋关节置换术并置入生物型假体者制定术前计划。符合入组条件的患者均接受术前 CT 扫描和常规 X 线检查。测量人员在术前应用 AIHIP 软件和 2D 数字模板进行测量,并将患者分为 AI 组与 2D 组。统计每组方案实施结果,包括髋臼杯假体型号、股骨柄假体型号。通过对这些数据的分析,确定了最适合于髋关节置换术,"[175.0, 223.0, 1016.0, 583.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +16,3,paragraph_title,2.1 术前规划方式 2.1.1 AIHIP 规划,"[175.0, 668.0, 417.0, 758.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.1 \u672f\u524d\u89c4\u5212\u65b9\u5f0f 2.1.1 AIHIP \u89c4\u5212""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +16,4,footer,,"[175.0, 728.0, 371.0, 758.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +16,5,paragraph_title,(1) 数据导入及智能分割,"[189.0, 768.0, 459.0, 800.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (1) \u6570\u636e\u5bfc\u5165\u53ca\u667a\u80fd\u5206\u5272""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +16,6,text,将 DICOM 格式的患者资料数据转为 “.cmg” 格式文件导入 AIHIP 系统,使用以二维 Dense-Unet 为主要结构的神经网络 G-NET 对骨骼进行自动分割,将骨骼分为不同区域,如骨盆区域与股骨区域。然后,通过 AIHIP 系统的 G-NET 对髋臼与股骨进行智能分割,建立骨盆与股骨的三维模型,并通过算法将髋臼与股骨头分离。分离后可单独观察股骨头或髋臼病变及骨缺损情况。,"[174.0, 818.0, 1016.0, 1039.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +16,7,image,,"[279.0, 1090.0, 955.0, 1373.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +16,8,figure_title,图 1 AIHIP 系统自动识别解剖位点,"[455.0, 1440.0, 775.0, 1467.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 1 AIHIP \u7cfb\u7edf\u81ea\u52a8\u8bc6\u522b\u89e3\u5256\u4f4d\u70b9""]",figure_caption,0.85,,legend_like,none,False,False +16,9,number,7,"[588.0, 1520.0, 603.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +16,10,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 385.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +17,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +17,1,paragraph_title,(2) 矫正与测量,"[189.0, 143.0, 364.0, 173.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (2) \u77eb\u6b63\u4e0e\u6d4b\u91cf""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +17,2,text,AIHIP 系统智能识别髋关节解剖标志点,如坐骨结节、髂前上棘、耻骨联合、大转子、小转子等,并根据骨骼结构自动测量髋臼大小、髓腔大小、股骨机械轴等数据。通过双侧髂前上棘与耻骨联合形成平面及尺骨联合中点与尾骨中点的连线,将骨盆调整至中立位,为选择合适大小的髋臼假体,调整髋臼假体前倾角及外展角做准备。根据识别的髋部解剖点,智能计算患者双下肢长度、双侧联合偏心距等参数,为安放股骨柄假体及术者手术提供数据,"[174.0, 193.0, 1015.0, 458.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +17,3,image,,"[279.0, 478.0, 953.0, 813.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +17,4,figure_title,图 2 AIHP 系统智能识别髋关节骨性标志点,"[413.0, 830.0, 817.0, 856.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 2 AIHP \u7cfb\u7edf\u667a\u80fd\u8bc6\u522b\u9acb\u5173\u8282\u9aa8\u6027\u6807\u5fd7\u70b9""]",figure_caption,0.85,,legend_like,none,False,False +17,5,paragraph_title,(3) 假体规划与模拟截骨,"[189.0, 910.0, 456.0, 940.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (3) \u5047\u4f53\u89c4\u5212\u4e0e\u6a21\u62df\u622a\u9aa8""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +17,6,text,在 AIHIP 系统智能识别并标定的解剖标志点的基础上,依据测算出的髋臼数据,自动识别髋臼假体安放位置并从数据库中智能匹配合适的髋臼杯型号。将髋臼假体数据导入患者 CT 数据中,并计划髋臼杯假体以外展角 45°,前倾角 15-20° 安放。本步骤中可对髋臼假体的位置、型号大小、外展角及前倾角进行调整,AIHIP 系统可根据调整数据实时显示髋臼假体与髋臼前后壁位置关系,并计算出调整后的髋臼覆盖率。,"[174.0, 960.0, 1015.0, 1226.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +17,7,number,8,"[588.0, 1520.0, 603.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +17,8,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,0,header,海南医学院硕士学位论文,"[493.0, 85.0, 697.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +18,1,image,,"[377.0, 155.0, 813.0, 440.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,2,figure_title,图 3 AIHP 系统自动匹配假体型号,"[436.0, 466.0, 754.0, 493.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 3 AIHP \u7cfb\u7edf\u81ea\u52a8\u5339\u914d\u5047\u4f53\u578b\u53f7""]",figure_caption,0.85,,legend_like,short_fragment,False,False +18,3,image,,"[381.0, 556.0, 573.0, 742.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,4,image,,"[618.0, 554.0, 811.0, 742.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,5,image,,"[381.0, 753.0, 573.0, 942.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,6,image,,"[618.0, 754.0, 811.0, 941.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,7,figure_title,图 4 AIHIP 系统安放髋臼假体并展示三维模拟位置,"[360.0, 963.0, 828.0, 990.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 4 AIHIP \u7cfb\u7edf\u5b89\u653e\u9acb\u81fc\u5047\u4f53\u5e76\u5c55\u793a\u4e09\u7ef4\u6a21\u62df\u4f4d\u7f6e""]",figure_caption,0.85,,legend_like,none,False,False +18,8,text,依据 AIHIP 软件识别的股骨髓腔形态与髓腔大小,自动匹配相应股骨柄。通过之前确定的髋臼及股骨旋转中心、双下肢长度、联合偏心距等匹配与安放合适的股骨柄假体及股骨柄球头。之后可根据假体安放后的双下肢长度及偏心距等对股骨柄安放深度、股骨柄前倾角、股骨内外翻角度微调,直至假体大小、位置、角度达到满意。软件根据假体截骨线对股骨三维模型进行自动截骨,显示完成股骨侧规划。,"[174.0, 1052.0, 1015.0, 1319.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +18,9,number,9,"[588.0, 1520.0, 603.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +18,10,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,0,header,海南医学院硕士学位论文,"[493.0, 85.0, 697.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +19,1,image,,"[238.0, 143.0, 951.0, 482.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +19,2,figure_title,图 5 AIHIP 自动规划股骨柄假体,"[446.0, 497.0, 744.0, 524.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 5 AIHIP \u81ea\u52a8\u89c4\u5212\u80a1\u9aa8\u67c4\u5047\u4f53""]",figure_caption,0.85,,legend_like,short_fragment,False,False +19,3,text,髋臼假体与股骨假体规划完成后,AIHIP 软件显示最终规划的髋臼杯型号、股骨柄型号、髋臼外展角、髋臼前倾角等参数,同时显示术前与术后及患侧与对侧的患肢长度及联合偏心距等。,"[175.0, 586.0, 1012.0, 710.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +19,4,paragraph_title,(4) 模拟髋关节极限运动状态,"[189.0, 728.0, 505.0, 759.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (4) \u6a21\u62df\u9acb\u5173\u8282\u6781\u9650\u8fd0\u52a8\u72b6\u6001""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +19,5,text,模拟髋关节的极限运动状态是指,在股骨柄与股骨锁死的情况下,进行围绕旋转中心的极限前屈、后伸等动作。这些动作可以帮助医生和研究人员更好地理解髋关节在不同运动状态下的力学特性和生物力学行为。在这种情况下,股骨柄和股骨之间的运动非常有限,因此需要进行极限运动测试来了解关节的极限运动范围。,"[174.0, 778.0, 1015.0, 996.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +19,6,paragraph_title,2.1.2 2D 数字化模板规划,"[175.0, 1086.0, 451.0, 1116.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.1.2 2D \u6570\u5b57\u5316\u6a21\u677f\u89c4\u5212""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +19,7,text,导入带有比例硬币的髋关节正位片,设定比例硬币长度为 25mm,纠正假体比例与髋关节正位片比例一致。鉴于髋臼假体的要求 $ ^{[21]} $,应当注意以下两点:①髋臼杯下缘需要保持平行状态,并且与泪滴下缘保持相同高度。②髋臼杯内侧缘距离泪滴外侧缘 5—10mm,位于髂坐线上,杯外侧缘超过髋臼上缘骨质,适当保留软骨下骨,保证假体覆盖率。股骨假体要求 $ ^{[22]} $:①根据股骨髓腔形状选择合适,"[174.0, 1134.0, 1015.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +19,8,number,10,"[584.0, 1521.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +19,9,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 697.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,1,text,及要求。根据上述标准选择髋臼杯与股骨柄的型号。,"[177.0, 151.0, 723.0, 182.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +20,2,image,,"[354.0, 262.0, 891.0, 715.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +20,3,figure_title,图 6 Smart joint 软件规划示意图,"[468.0, 736.0, 764.0, 763.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 6 Smart joint \u8f6f\u4ef6\u89c4\u5212\u793a\u610f\u56fe""]",figure_caption,0.85,,unknown_like,none,False,False +20,4,paragraph_title,2.2 手术方法,"[175.0, 861.0, 358.0, 895.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.2 \u624b\u672f\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +20,5,text,本文介绍了 100 例进行第一次 THA 的治疗方案,并通过随机方法将患者分成了 AI 组和 2D 组,每组有 50 例患者。其中 AI 组用 AIHIP 系统进行规划术前规划,根据 AIHIP 系统建议的股骨颈截骨量以及髋臼外展角和前倾角进行髋臼磨挫。2D 组用 Smart Joint 软件进行术前规划,按照标准后外侧入路全髋关节置换术式进行手术,髋臼外展角按照 45° 进行磨挫规划。两种治疗方,"[174.0, 928.0, 1014.0, 1335.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,6,text,手术过程:在患者身上,首先需要确定切口的起点,在大粗隆尖上方 3.0cm 处标记。随后,切口开始沿着臀大肌纤维方向向下延伸,直至股骨大转子下方 5.0cm 处,整个切口长度约为 15.0cm。接下来,依次切开组织,以显露出大粗隆。,"[175.0, 1359.0, 1015.0, 1484.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +20,7,number,11,"[583.0, 1521.0, 607.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,8,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +21,1,text,分离后方,显露出相应的外旋肌群。切断间窝位置,并且进行牵开外旋肌群的处理,同时还应保护坐骨神经的健康状态。随后,需要对脂肪组织进行分离,以显露出相应的关节囊,并切开囊来实现脱位。对大、小转子区域,需要对相应的股骨颈进行截骨的基本操作,然后再进行股骨头的取出操作。完成这些操作之后,使用髋臼拉钩来有效显露,并彻底清理相关软组织,这样可以显露出真性髋臼,为接下来的手术操作做好准备。使用髋臼锉从 38 m,"[175.0, 152.0, 1016.0, 839.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,2,paragraph_title,2.3 术后处理,"[176.0, 925.0, 357.0, 960.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.3 \u672f\u540e\u5904\u7406""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +21,3,text,术后采取相应的禁食处理 6 小时,结合基础病状况调整饮食。术后 1 天内,提供相应的护理、监护以及吸氧等支持。手术之后,提供相应的低分子量肝素,有效预防血栓 24 小时。抗生素方面的具体运用是 48 小时。出院后口服利伐沙班至第 12 天;切口 2—3 天进行换药操作 1 次。手术之后的第 14 天,结合具体的愈合状况进行拆线。手术之后监控具体的引流量,低于 50ml 拔除。,"[174.0, 992.0, 1013.0, 1212.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,4,text,术后第 1 天:指导患者平卧于床上行踝泵锻炼以及股四头肌锻炼,促进患肢血液循环以及肌肉力量的恢复,防止下肢深静脉血栓形成。,"[176.0, 1236.0, 1013.0, 1314.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,5,text,术后第 2 至 3 天:嘱患者在不负重或者负重条件下进行患侧下肢肌力及髋膝关节活动度训练,训练应包含相应的屈髋屈膝动作(屈髋方面低于 $ 90^{\circ} $ )、髋关节外展以及伸直,进行相应的直腿抬高等动作。,"[176.0, 1340.0, 1011.0, 1464.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,6,number,12,"[584.0, 1520.0, 607.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +21,7,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +22,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 109.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +22,1,text,术后 3 天至 2 周:鼓励患者主动床旁站立,在助行器辅助下尝试病房内行走的基础上进行步态训练及身体平衡性训练。,"[175.0, 151.0, 1013.0, 231.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +22,2,text,术后 2 周至 3 个月,患者应在出院后的 2 周内进行轻度锻炼。在接下来的 3 月内避免髋关节屈曲大于 90 度,关节活动要求恢复术前日常活动。,"[175.0, 255.0, 1014.0, 333.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +22,3,paragraph_title,2.4 观察项目,"[175.0, 435.0, 356.0, 471.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.4 \u89c2\u5bdf\u9879\u76ee""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +22,4,text,(1) 术前资料:包括一般资料,如 BMI、年龄和性别。术前患者下肢长度差值,术前髋关节 Harris 评分,AI 组及 2D 组两种方式规划时间。,"[175.0, 502.0, 1009.0, 582.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +22,5,text,(2) 术中资料:手术时间(切皮至关闭手术切口),术中出血量及术中实际所采用的髋关节假体型号。,"[175.0, 604.0, 1013.0, 684.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +22,6,text,(3) 术后资料:术后双下肢长度差值,术后髋关节正位片外展角度,术后股骨柄—髓腔轴线夹角,术后股骨柄—髓腔比,术后1月、3月、6月髋关节Harris评分。,"[175.0, 718.0, 1015.0, 849.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +22,7,paragraph_title,2.5 统计学方法,"[175.0, 993.0, 387.0, 1029.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.5 \u7edf\u8ba1\u5b66\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +22,8,text,对所有数据进行处理时,采用 SPSS 25.0 软件。正态分布的计量数据使用 t 检验进行处理,非正态分布的计量数据使用秩和检验进行处理,等级数据则使用卡方检验。计量数据以均数±标准差的形式进行描述。显著性水平 P<0.05 表示差异具有统计学意义。,"[174.0, 1060.0, 1015.0, 1233.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +22,9,number,13,"[584.0, 1520.0, 607.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +22,10,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +23,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +23,1,paragraph_title,3 研究结果,"[176.0, 155.0, 328.0, 192.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3 \u7814\u7a76\u7ed3\u679c""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +23,2,paragraph_title,3.1 术前资料比较 3.1.1 一般资料,"[175.0, 228.0, 418.0, 318.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1 \u672f\u524d\u8d44\u6599\u6bd4\u8f83 3.1.1 \u4e00\u822c\u8d44\u6599""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +23,3,footer,,"[175.0, 287.0, 348.0, 318.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +23,4,text,AI 组和 2D 组的患者在手术部位、年龄、性别、体重指数(BMI)和髋关节 Harris 评分等一般资料比较的差异均无统计学意义(P>0.05),AI 组与 2D 组的观察资料具有可比性。(表 1)。,"[174.0, 336.0, 1016.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +23,5,figure_title,表 1 AI 组和 2D 组术前一般资料比较,"[396.0, 486.0, 792.0, 516.0]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 1 AI \u7ec4\u548c 2D \u7ec4\u672f\u524d\u4e00\u822c\u8d44\u6599\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +23,6,table,
因素AI 组 (n=50)2D 组 (n=50)$ t/\chi^{2} $P
年龄(岁)$ 56.52 \pm 13.45 $$ 60.60 \pm 12.10 $-1.5920.1,"[167.0, 521.0, 1021.0, 1047.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +23,7,vision_footnote,注:AI 组和 2D 组患者术前一般资料无明显差异,无统计学意义。,"[175.0, 1061.0, 783.0, 1090.0]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u548c 2D \u7ec4\u60a3\u8005\u672f\u524d\u4e00\u822c\u8d44\u6599\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u3002""]",footnote,0.7,,unknown_like,none,True,True +23,8,paragraph_title,3.1.2 术前规划时间,"[197.0, 1183.0, 418.0, 1214.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1.2 \u672f\u524d\u89c4\u5212\u65f6\u95f4""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +23,9,text,AI 组术前规划时间最长 451 秒,最短 355 秒,平均规划时间为 $ 401.56 \pm 31.36 $ 秒。2D 组术前规划时间最长为 312 秒,最短规划时间为 210 秒,平均规划时间为 $ 266.48 \pm 29.42 $ 秒。AI 组术前规划时间略长于 2D 组,且两组在术前规划时间上的比较差异有统计学意义(P < 0.05)(表 2)。,"[173.0, 1232.0, 1016.0, 1405.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,10,number,14,"[583.0, 1520.0, 609.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +23,11,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +24,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +24,1,figure_title,表 2 AI 组和 2D 组术前规划时间比较,"[398.0, 143.0, 791.0, 171.0]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 2 AI \u7ec4\u548c 2D \u7ec4\u672f\u524d\u89c4\u5212\u65f6\u95f4\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +24,2,table,
因素AI 组(n=50)2D 组(n=50)$ t/\chi^{2} $P
术前规划时间(秒)$ 401.56 \pm 31.36 $$ 266.48 \pm 29.42 $0.252,"[168.0, 171.0, 1019.0, 285.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +24,3,vision_footnote,注:AI 组和 2D 组规划时间比较有明显差异,有统计学意义。,"[175.0, 301.0, 742.0, 329.0]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u548c 2D \u7ec4\u89c4\u5212\u65f6\u95f4\u6bd4\u8f83\u6709\u660e\u663e\u5dee\u5f02\uff0c\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002""]",footnote,0.7,,unknown_like,none,True,True +24,4,chart,,"[233.0, 398.0, 965.0, 817.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +24,5,figure_title,图 7 AI 组与 2D 组术前规划时间箱型图,"[411.0, 861.0, 778.0, 889.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 7 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u524d\u89c4\u5212\u65f6\u95f4\u7bb1\u578b\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +24,6,paragraph_title,3.2 术中资料比较 3.2.1 手术时间,"[175.0, 954.0, 417.0, 1044.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.2 \u672f\u4e2d\u8d44\u6599\u6bd4\u8f83 3.2.1 \u624b\u672f\u65f6\u95f4""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +24,7,footer,,"[198.0, 1014.0, 371.0, 1044.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +24,8,text,AI 组手术时间最长为 122 分钟,最短手术时间为 60 分钟,平均手术时间为 $ 92.66 \pm 14.30 $ 分钟。2D 组手术时间最长为 157 分钟,最短手术时间为 70 分钟,平均手术时间为 $ 103.82 \pm 16.05 $ 分钟。两组在手术时间的比较有明显差异,有统计学意义(P < 0.05)(表 3、图 8)。两组手术时间对比,AI 组能有效的缩短手术时间。,"[172.0, 1064.0, 1016.0, 1283.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,9,number,15,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +24,10,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +25,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +25,1,chart,,"[221.0, 150.0, 981.0, 589.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +25,2,figure_title,图 8 AI 组与 2D 组手术时间箱型图,"[432.0, 622.0, 757.0, 650.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 8 AI \u7ec4\u4e0e 2D \u7ec4\u624b\u672f\u65f6\u95f4\u7bb1\u578b\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +25,3,paragraph_title,3.2.2 术中出血量,"[198.0, 693.0, 393.0, 722.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.2.2 \u672f\u4e2d\u51fa\u8840\u91cf""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +25,4,text,AI 组术中出血量最大为 700 ml,最小为 30 ml,平均术中出血为 207.60±131.98 ml。2D 组术中出血量最大为 800 ml,最小为 100 ml,平均术中出血为 274.00±150.02 ml。两组在术中出血量的差异有统计学意义(P<0.05),且 AI 组手术出血量少于 2D 组(表 3)。,"[174.0, 743.0, 1017.0, 913.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +25,5,chart,,"[212.0, 929.0, 985.0, 1369.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +25,6,figure_title,图 9 AI 组与 2D 组术中出血量箱型图,"[422.0, 1400.0, 767.0, 1427.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 9 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u4e2d\u51fa\u8840\u91cf\u7bb1\u578b\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +25,7,number,16,"[583.0, 1520.0, 609.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +25,8,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +26,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +26,1,paragraph_title,3.2.3 假体预测准确性,"[197.0, 143.0, 441.0, 173.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.2.3 \u5047\u4f53\u9884\u6d4b\u51c6\u786e\u6027""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +26,2,text,本研究以术前规划假体型号与术中实际应用假体型号完全一致为规划准确。研究中采用的全髋关节人工假体为美国强生公司 PINNACLE 非骨水泥型生物杯和 TRILOCK 非骨水泥型生物柄,其中髋臼杯最小号为 42 号,型号依次以 44、46、48 递增至 66 号。股骨柄最小号为 0 号,型号依次以 1、2、3 递增至 12 号。AI 组术前规划与术中实际应用髋臼杯假体与股骨柄假体准确率为 76%(38,"[173.0, 193.0, 1016.0, 694.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,3,chart,,"[225.0, 769.0, 947.0, 1186.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +26,4,figure_title,图 10 AI 组与 2D 组髋臼假体型号分布,"[417.0, 1214.0, 772.0, 1240.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 10 AI \u7ec4\u4e0e 2D \u7ec4\u9acb\u81fc\u5047\u4f53\u578b\u53f7\u5206\u5e03""]",figure_caption,0.85,,legend_like,none,False,False +26,5,number,17,"[584.0, 1520.0, 608.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +26,6,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +27,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 109.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +27,1,chart,,"[226.0, 187.0, 946.0, 606.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +27,2,figure_title,图 11 AI 组与 2D 组股骨柄假体型号分布,"[407.0, 631.0, 783.0, 659.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 11 AI \u7ec4\u4e0e 2D \u7ec4\u80a1\u9aa8\u67c4\u5047\u4f53\u578b\u53f7\u5206\u5e03""]",figure_caption,0.85,,legend_like,none,False,False +27,3,figure_title,表 3 AI 组和 2D 组术中资料比较,"[422.0, 762.0, 768.0, 792.0]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 3 AI \u7ec4\u548c 2D \u7ec4\u672f\u4e2d\u8d44\u6599\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +27,4,table,0.05)(表 4)。AI 组与 2D 组术前规划在改善髋臼假体外展角上无明显差异,但 AI 组术后髋臼外展角相关性较 2D 组更强(图 12)。,"[175.0, 264.0, 1017.0, 483.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +28,4,chart,,"[271.0, 505.0, 964.0, 953.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +28,5,figure_title,图 12 AI 组与 2D 组术后髋臼假体外展角分布情况,"[364.0, 980.0, 824.0, 1007.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 12 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u9acb\u81fc\u5047\u4f53\u5916\u5c55\u89d2\u5206\u5e03\u60c5\u51b5""]",figure_caption,0.85,,legend_like,none,False,False +28,6,paragraph_title,3.3.2 术后两组股骨柄一髓腔比例比较,"[198.0, 1101.0, 605.0, 1131.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.3.2 \u672f\u540e\u4e24\u7ec4\u80a1\u9aa8\u67c4\u4e00\u9ad3\u8154\u6bd4\u4f8b\u6bd4\u8f83""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +28,7,text,AI 组术后股骨柄-髓腔比最大为 94.85%,最小为 84.5%,平均股骨柄-髓腔比为 $ 89.34 \pm 3.09\% $。2D 组股骨柄-髓腔比最大为 93.35%,最小为 81%,平均股骨柄-髓腔比为 $ 86.35 \pm 3.42\% $。两组股骨柄-髓腔比差异明显,有统计学意义(P<0.05)(表 4)。AI 术前规划能更加准确的规划股骨假体大小,获得更优的股骨柄-髓腔占比结,"[173.0, 1151.0, 1016.0, 1370.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +28,8,number,19,"[584.0, 1520.0, 608.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +28,9,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +29,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +29,1,chart,,"[279.0, 161.0, 962.0, 525.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +29,2,figure_title,图 13 AI 组与 2D 组术后股骨柄-髓腔比例分布情况,"[354.0, 560.0, 836.0, 587.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 13 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u80a1\u9aa8\u67c4\uff0d\u9ad3\u8154\u6bd4\u4f8b\u5206\u5e03\u60c5\u51b5""]",figure_caption,0.85,,legend_like,none,False,False +29,3,paragraph_title,3.3.3 术后两组股骨柄一髓腔轴线比较,"[197.0, 641.0, 606.0, 671.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.3.3 \u672f\u540e\u4e24\u7ec4\u80a1\u9aa8\u67c4\u4e00\u9ad3\u8154\u8f74\u7ebf\u6bd4\u8f83""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +29,4,text,AI 组术后股骨柄-髓腔轴线夹角最大 3.12°,最小为 1.13°,平均股骨柄-股骨轴线夹角为 2.67±0.43。2D 组术后股骨柄-髓腔轴线夹角最大为 4.11°,最小为 1.12°,平均股骨柄-髓腔轴线夹角为 2.66±0.62°。两组比较差异不明显,无统计学意义(P>0.05)(表 4)。本研究以股骨柄-髓腔轴线夹角≤3°即股骨柄中心固定为准确,>3°股骨柄外翻固定或内翻固定为不准确。A,"[174.0, 689.0, 1015.0, 1098.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +29,5,number,20,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +29,6,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +30,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 109.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +30,1,chart,,"[195.0, 155.0, 1003.0, 622.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +30,2,figure_title,图 14 AI 组与 2D 组术后股骨柄—髓腔夹角分布情况,"[353.0, 653.0, 836.0, 681.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 14 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u80a1\u9aa8\u67c4\u2014\u9ad3\u8154\u5939\u89d2\u5206\u5e03\u60c5\u51b5""]",figure_caption,0.85,,legend_like,none,False,False +30,3,figure_title,表 4 AI 组和 2D 组术后假体位置比较,"[398.0, 756.0, 791.0, 787.0]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 4 AI \u7ec4\u548c 2D \u7ec4\u672f\u540e\u5047\u4f53\u4f4d\u7f6e\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +30,4,table,
因素AI 组 (n=50)2D 组 (n=50)$ t/\chi^{2} $P
手术时间(分钟)$ 92.66 \pm 14.30 $$ 103.82 \pm 16.05 $-3.670
因素AI 组 (n=50)2D 组 (n=50)$ t/\chi^{2} $P
髋臼外展角(°)$ 42.07 \pm 4.78 $$ 41.26 \pm 5.19 $0.6590.4,"[168.0, 791.0, 1022.0, 1285.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +30,5,vision_footnote,注:AI 组与 2D 组术后髋臼外展角、股骨柄-股骨轴线夹角及股骨柄-股骨轴线夹角准确率比较无明显差异,无统计学意义。与 2D 组相比,AI 组股骨柄-髓腔比率更优,股骨柄稳定性更强,两组结果对比有差异,具有统计学意义。,"[173.0, 1298.0, 1018.0, 1390.0]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u9acb\u81fc\u5916\u5c55\u89d2\u3001\u80a1\u9aa8\u67c4\uff0d\u80a1\u9aa8\u8f74\u7ebf\u5939\u89d2\u53ca\u80a1\u9aa8\u67c4\uff0d\u80a1\u9aa8\u8f74\u7ebf\u5939\u89d2\u51c6\u786e\u7387\u6bd4\u8f83\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u4e0e""]",footnote,0.7,,unknown_like,none,True,True +30,6,number,21,"[582.0, 1519.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +30,7,footer,中国知网 https://www.cnki.net,"[37.0, 1620.0, 385.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +31,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +31,1,paragraph_title,3.3.4 术后两组双下肢长度比较,"[196.0, 143.0, 537.0, 173.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.3.4 \u672f\u540e\u4e24\u7ec4\u53cc\u4e0b\u80a2\u957f\u5ea6\u6bd4\u8f83""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +31,2,text,AI组和2D组术前与术后双下肢长度组间比较差异无统计学意义(P<0.05),AI组和2D组术前与术后双下肢长度比较差异明显,均有统计学意义(P<0.05)。AI组与2D组通过手术都有效地改善了下肢长度,当我们定义双下肢长度差异>5mm为下肢不等长,AI组中有1名患者发生下肢不等长,而2D组有2名患者(图15,图16)。另外,AI组术后下肢长度差异平均值为0.06±0.36cm,较2D组术后下肢长度,"[173.0, 192.0, 1016.0, 506.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +31,3,figure_title,表 5 AI 组和 2D 组术后双下肢长度差异比较,"[385.0, 585.0, 851.0, 616.0]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 5 AI \u7ec4\u548c 2D \u7ec4\u672f\u540e\u53cc\u4e0b\u80a2\u957f\u5ea6\u5dee\u5f02\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +31,4,table,
参数术前术后t值p值
2D组(cm)$ -1.01 \pm 0.78 $$ 0.07 \pm 0.30 $-8.8420.00
AI组(cm)
组别n术后1月(分)术后3月(分)术后6月(分)F值P值
AI组50$ 73.14 \pm 6.82 $$ 81.98 \pm 2.38 $$ 9,"[166.0, 1123.0, 1021.0, 1376.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +32,7,vision_footnote,注:AI 组与 2D 组相比,术后 1 月和术后 6 月髋关节评分更高,AI 术前规划精准规划髋关节活动角度及假体位置,促进患者术后关节功能恢复。,"[173.0, 1386.0, 1014.0, 1446.0]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u4e0e 2D \u7ec4\u76f8\u6bd4\uff0c\u672f\u540e 1 \u6708\u548c\u672f\u540e 6 \u6708\u9acb\u5173\u8282\u8bc4\u5206\u66f4\u9ad8\uff0cAI \u672f\u524d\u89c4\u5212\u7cbe\u51c6\u89c4\u5212\u9acb\u5173\u8282\u6d3b\u52a8\u89d2\u5ea6\u53ca\u5047\u4f53\u4f4d\u7f6e\uff0c""]",footnote,0.7,,unknown_like,none,True,True +32,8,number,23,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +32,9,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +33,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +33,1,chart,,"[204.0, 149.0, 995.0, 701.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +33,2,figure_title,图 17 AI 组与 2D 组术前术后髋关节 Harris 评分估算边际平均值,"[300.0, 746.0, 887.0, 774.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 17 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u524d\u672f\u540e\u9acb\u5173\u8282 Harris \u8bc4\u5206\u4f30\u7b97\u8fb9\u9645\u5e73\u5747\u503c""]",figure_caption,0.85,,legend_like,none,False,False +33,3,number,24,"[583.0, 1520.0, 608.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +33,4,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1651.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +34,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +34,1,paragraph_title,4 讨论,"[175.0, 155.0, 270.0, 191.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 4 \u8ba8\u8bba""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +34,2,text,"从 19 世纪 60 年代起,全髋关节置换术就已经发展成为一种常见的外科手术,它可以有效地治疗髋部骨关节炎、病理性关节磨损等慢性疾病。随着科学技术的发展,现代全髋关节置换术已经取得了长足的进步与发展,它可以更好地恢复患者的关节活动能力。髋关节不稳定、机械松动、术后脱位、双下肢不等长等因素是导致 THA 翻修和影响髋关节手术成功率的主要因素 $ ^{[23,24]} $。因此,完备的术前准备和设计对","[174.0, 224.0, 1016.0, 678.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +34,3,text,随着数字化骨科技术的发展,全髋关节置换术的术前规划方式也从广泛应用的二维胶片模板与数字化模板规划方式发展到基于 CT 或 MRI 扫描的三维模板规划方式,假体型号的预测精准度也在不断地提高。然而三维规划方式不仅对于规划者的专业知识要求十分严苛,而且操作过程繁琐耗时,硬件设备要求高,无法在偏远地区医院与基层医院推广。本研究使用基于人工智能的三维规划软件,与传统的二维模板相比精准度得到了大幅度提高,同,"[174.0, 701.0, 1016.0, 1203.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +34,4,text,二维模板规划是目前应用最广泛的规划方法,具备操作简单、辐射剂量低、技术要求低、价格低等优点,但同样存在放大倍率不确定、提供信息量少、测量误差大等缺点。数字模板的准确性取决于放大标记的准确性及其在髋关节水平上估计骨骼真实放大率的能力,放大率差异最常见的解决方法是使用硬币或金属球进行外部标记 $ ^{[8]} $。由于二维模板术前规划是基于髋关节正位片(前后位投影)进行操作,无法准确反映髋关节的复杂骨,"[174.0, 1226.0, 1016.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +34,5,number,25,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +34,6,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +35,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +35,1,text,线投射的同一平面发生重叠时,容易导致术前规划的误差。另外,患者规划侧出现股骨弯曲或旋转时,髋关节生物力学测量则发生股骨偏移等误差,影响假体型号与放置位置的选择 $ ^{[26]} $。,"[176.0, 151.0, 1014.0, 275.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +35,2,text,三维模板规划是基于高分辨率 CT 或 MRI 图像,利用计算机软件对患者数据进行分割处理后转化为虚拟三维模型,并在此基础上进行假体规划和手术过程模拟。三维模板规划的优势在于 CT 成像可清晰显示髋臼前倾角、髋臼外展角、髋臼前后壁厚度、股骨前倾角以及股骨近端等解剖结构。在复杂的病例和 THA 翻修手术中,三维模板规划可直观地展示髋关节骨性结构的骨溶解和骨丢失等情况 $ ^{[27]} $。基于 AI,"[175.0, 303.0, 1016.0, 944.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,3,text,本研究显示,AI 组术前规划与术中实际应用髋臼杯假体与股骨柄假体准确率为 76%(38/50)和 70%(35/50),2D 组术前规划与术中实际应用髋臼杯与股骨柄假体准确率为 58%(29/50)和 54%(27/50)。髋臼杯假体与股骨柄假体在 1 个型号范围内准确率,AI 组与 2D 组分别为 96%(48/50),96%(48/50)和 76%(38/50),70%(35/50)。与 2D,"[175.0, 968.0, 1016.0, 1513.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +35,4,number,26,"[583.0, 1521.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +35,5,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +36,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +36,1,text,当的方案调整是有必要的。,"[177.0, 151.0, 460.0, 182.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +36,2,text,"股骨和髋臼精准的生物力学重建对于术后满意的髋关节功能至关重要 $ ^{[31]} $。若放置不当,可能会导致假体撞击等并发症。为了减少类似术后并发症的发生,对于安放髋臼假体而言,最关键的是准确地定位髋关节旋转中心 $ ^{[32]} $。此外,髋关节的旋转中心对于恢复肌肉功能 $ ^{[33,34]} $、关节稳定性 $ ^{[35,36]} $和髋关节假体寿命 $ ^{[37]} $也至关重要。","[175.0, 208.0, 1017.0, 946.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +36,3,text,1993 年,Dorr $ ^{[40]} $首次在骨盆正位片依据股骨一髓腔比将股骨髓腔分为香槟杯型、普通型和烟囱型,这种分型方式至今被骨科医生们使用。二维术前规划选择股骨假体利用的相同的原理。然而有学者发现,股骨髓腔同一水平面,冠状面与矢状面髓腔直径存在明显差异 $ ^{[41]} $。另外,Mikayla Forness $ ^{[42]} $等人研究发现,髋关节旋转 15°,屈曲 5° 的变,"[174.0, 968.0, 1016.0, 1468.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +36,4,number,27,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +36,5,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +37,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +37,1,text,良好的术前规划,可以避免假体置入的盲目性,避免反复试模与压配、调整过程造成的手术时间的延长。手术时间的缩短,可减少切口创面的渗血。由AI组与2D组研究结果可知,AI组平均手术时间为92.66±14.30分钟;2D组平均手术时间为103.82±16.05,AI组术中平均出血量为207.60±131.98ml;2D组术中出血量274.00±150.02ml,AI组与2D组术中出血量与手术时间存在正相关,"[175.0, 153.0, 1015.0, 464.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +37,2,text,根据相关研究显示 $ ^{[44-46]} $,精准的假体位置能够改善人工关节活动范围,延长人工关节使用寿命,有效避免假体撞击、假体不稳、假体脱位等并发症。本研究发现,在术后3个月时,两组的Harris指数没有显著差异(P>0.05);但在术后1个月和6个月时,AI组的数据明显高于2D组,差异具有统计学意义(P<0.05)。通过比较术后两组髋关节Harris评分,我们认为AI术前规划提供给医生精准,"[175.0, 490.0, 1015.0, 802.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +37,3,text,我们的研究同时还比较了两种规划方法的规划时间,结果显示,AI 组的规划时间为 $ 401.56 \pm 31.36 $ 秒,比 2D 组规划时间 $ 266.48 \pm 29.42 $ 秒略长。关于术前规划时间的研究既往也有学者报道,Robert $ ^{[47]} $等人报道使用醋酸盐模板法进行模板化的平均时间为 119 秒,而使用数字模板法进行的平均时间则为 154 秒,平均差异为 35,"[175.0, 827.0, 1016.0, 1373.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +37,4,text,髋关节置换术作为骨科中难度与复杂程度较大的手术,完善的手术器械及假体备货同样影响手术的成功率。传统的术前器械与假体准备往往通过多套手,"[177.0, 1398.0, 1013.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +37,5,number,28,"[583.0, 1520.0, 608.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +37,6,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +38,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +38,1,text,术器械及大量假体型号备货预防与解决手术过程中假体不匹配、假体大小偏差等问题,但由于髋臼与股骨个体发育差异,仍然出现假体与患者髋臼或股骨髓腔不匹配等情况。另外,大量的器械和假体备货提高手术相关的消毒成本,增加供应室相关工作人员的工作压力与负担,可能间接导致器械无菌消毒不合格,手术感染风险升高等问题。研究过程中我们发现,人工智能三维术前规划能够提供更加精准的假体大小和型号,器械与假体只需根据术前规划报,"[174.0, 151.0, 1015.0, 512.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +38,2,text,骨科是医患纠纷较为常见的科室。因此,对医患交流质量有极高的要求 $ ^{[50]} $。优秀的术前沟通对于获得患者的信任至关重要,也是避免纠纷的关键 $ ^{[51]} $。以往医生进行术前谈话,多依靠患者的X线,CT或者MRI等影像学资料。患者及家属理解晦涩难懂的影像学资料存在一定的困难,同时,要求他们在理解的基础上了解手术必要性与相关风险具有非常大的难度。我们发现,人工智能术前规划提供直观的三,"[175.0, 535.0, 1015.0, 944.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +38,3,text,髋关节作为人体最复杂的关节之一,髋关节置换术的成功率与医师经验有关,高年资医师的手术预后较好,对于青年医师初期进行关节置换手术操作,手术效果往往不是很理想。人工智能三维术前规划,通过三维骨性结构的重建提供清晰的髋臼病损改变,预测术中可能出现的困难,规避术中并发症,并对手术过程进行预测。另外,AI术前规划准确规划术前假体大小及位置角度,提供了一种学习假体选择和安放的良好方式,缩短髋关节置换术的学习周,"[174.0, 966.0, 1016.0, 1281.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +38,4,number,29,"[583.0, 1520.0, 608.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +38,5,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +39,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +39,1,paragraph_title,5 研究的局限性,"[175.0, 156.0, 386.0, 192.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 5 \u7814\u7a76\u7684\u5c40\u9650\u6027""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +39,2,text,本研究所采用的 AIHIP 系统可以准确预测假体型号,并在术后髋关节功能评测上获得了良好的结果。然而仍然存在一定的局限性:①本研究只纳入了强生公司的单类型假体,未对其他型号假体及其他品牌假体进行评测。②本研究仅纳入单侧初次全髋关节置换患者,未对双侧全髋关节置换、先天性髋关节发育不良、髋关节假体失效、初次髋关节置换术后髋臼严重缺损需翻修等患者进行应用研究。③本研究术后假体位置及稳定性仅依靠髋关节正位,"[174.0, 223.0, 1015.0, 773.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +39,3,number,30,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +39,4,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +40,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +40,1,paragraph_title,6 结论,"[175.0, 156.0, 269.0, 192.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 6 \u7ed3\u8bba""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +40,2,text,通过短期临床随访,AIHIP系统可以辅助术者在THA手术中实现精准的假体型号与假体位置安放,减少术中反复磨挫及试模次数,缩短手术时间,减少术中出血量,降低术后假体失效率,促进患者术后髋关节功能的恢复,可以有效地应用于临床。,"[173.0, 223.0, 1015.0, 397.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +40,3,number,31,"[583.0, 1520.0, 607.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +40,4,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +41,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 697.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +41,1,paragraph_title,参考文献,"[526.0, 155.0, 665.0, 192.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u53c2\u8003\u6587\u732e""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +41,2,reference_content,"[1] Learmonth I D, Young C, Rorabeck C. 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It can reconstruct joint function and improve the quality of life of patients, but d","[174.0, 1060.0, 1018.0, 1511.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +46,6,number,37,"[583.0, 1520.0, 607.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +46,7,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +47,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +47,1,abstract,"infection, unequal length of lower limbs and other factors are still the main reasons for revision after hip joint surgery. Primary factor. Accurate prosthesis placement, excellent hip function and lo","[175.0, 153.0, 1017.0, 745.0]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +47,2,paragraph_title,Keywords: total hip arthroplasty; preoperative planning; prosthesis type,"[175.0, 809.0, 893.0, 838.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Keywords: total hip arthroplasty; preoperative planning; pro""]",subsection_heading,0.6,,unknown_like,none,True,True +47,3,text,全髋关节置换术(Total hip arthroplasty,THA)是髋关节骨性关节炎、老年股骨颈骨折及股骨头坏死最常见的治疗方案之一,在全世界范围内广泛开展,被誉为20世纪最成功的手术 $ ^{[1]} $。据不完全统计,我国2018年约有40万人接受髋关节置换手术,并且将以每年20%的速度快速增长 $ ^{[2]} $。随着材料学的发展和手术技术的进步,髋关节置换术的短期与长期疗效都获得了巨,"[174.0, 886.0, 1016.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +47,4,text,THA 术前规划最主要的方式是模板测量,即术前使用髋关节 x 线片或计算机断层扫描(CT)等影像学检查,预测植入的人工关节假体大小和位置的过程 $ ^{[6]} $。模板术前测量可以帮助术者精准选择合适假体大小,同时规划股骨颈截骨高度、髋臼磨挫深度及假体安放位置。因此,术前规划和测量可有效降低术后假体松动、假体周围骨折、髋关节脱位等 THA 手术并发症的发生率。同时,精确术前,"[175.0, 1259.0, 1015.0, 1478.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +47,5,number,38,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +47,6,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +48,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +48,1,text,规划和测量可预测手术难度,完善围手术期器械准备,缩短手术时间,降低手术风险 $ ^{[7]} $。,"[175.0, 151.0, 1002.0, 227.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +48,2,paragraph_title,1. 全髋关节置换术前规划方式的进展,"[176.0, 297.0, 668.0, 331.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1. \u5168\u9acb\u5173\u8282\u7f6e\u6362\u672f\u524d\u89c4\u5212\u65b9\u5f0f\u7684\u8fdb\u5c55""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,True,True +48,3,text,完整的术前准备及设计对于 THA 非常重要,选用适当尺寸型号假体可得到较低的手术截骨量,重建偏心距及下肢长度、优化假体的位置,获得更大的假体稳定性,更好的症状缓解程度及关节功能,同时保证手术安全及减少费用等 $ ^{[8]} $。随着科技的进步,计算机技术,人工智能、大数据被广泛运用于医学领域,促进着医学事业的飞跃发展,手术前假体规划由原来的胶片模板、数字模板二维平面图像,发展到建模软件进行三维立,"[175.0, 355.0, 1015.0, 714.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +48,4,paragraph_title,1.1 二维模板测量法,"[224.0, 734.0, 506.0, 769.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1 \u4e8c\u7ef4\u6a21\u677f\u6d4b\u91cf\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +48,5,text,模板测量是关节置换术前计划中常规的一步,自全髋关节置换术诞生伊始,Charnley $ ^{[9]} $和Muller $ ^{[10]} $等都强调了使用术前X片进行规划的重要性。二维模板测量法主要包括胶片模板法和数字模板法。胶片模板是由器械设备公司提供的手工薄膜模板,其上印有各型号大小的假体轮廓图案,将胶片模板与患者髋关节正位片重叠,选择合适假体类型。数字模板是指用影像处理软件制作出数字化的假,"[174.0, 792.0, 1014.0, 1151.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +48,6,paragraph_title,1.1.1 X 线摄片,"[225.0, 1166.0, 397.0, 1195.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 1.1.1 X \u7ebf\u6444\u7247""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +48,7,text,在拍摄髋关节正位 X 线片时要求患者仰卧摄影台上,双下肢伸直,双足内旋并拢(10° -15°),源—像距离 100cm $ ^{[11]} $。标准髋关节正位片要求显示双侧骨盆,骶骨和腰椎的下部,及远端股骨至峡部水平。股骨头显示照片正中,股骨颈无投影变形,髋关节各骨纹理清晰锐利,坐骨棘清晰 $ ^{[12]} $。在拍摄 X 线片时常规放入一个带有标尺的金属球或标准硬币,拍摄完成后选用与 x 线片,"[174.0, 1213.0, 1015.0, 1479.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +48,8,number,39,"[583.0, 1520.0, 607.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +48,9,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +49,0,header,海南医学院硕士学位论文,"[492.0, 84.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +49,1,image,,"[349.0, 158.0, 885.0, 529.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +49,2,figure_title,图 1 髋关节摄片体位,"[517.0, 557.0, 715.0, 585.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 1 \u9acb\u5173\u8282\u6444\u7247\u4f53\u4f4d""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +49,3,paragraph_title,1.1.2 标记骨性解剖,"[224.0, 697.0, 452.0, 727.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1.2 \u6807\u8bb0\u9aa8\u6027\u89e3\u5256""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +49,4,text,骨性解剖包括下列(图 2):a、泪滴:髋臼杯下缘的骨性标记;b、髋臼上缘:髋臼杯上缘的骨性标记,可用来评估髋臼覆盖率;c、髂坐线:髂骨内缘与坐骨内缘的连线,用来评估髋臼杯放置深度;d、大转子:重建股骨旋转中心及股骨偏心距骨性标志;e、小转子:术前术后影像学评估双下肢长度的骨性标志。f、旋转中心:髋关节活动的中心,用于评估髋臼杯或股骨头假体旋转中心位置的标志(非骨性标志)。,"[175.0, 745.0, 1013.0, 1011.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +49,5,image,,"[455.0, 1022.0, 783.0, 1444.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +49,6,figure_title,图 2 髋关节骨性标志(左侧),"[478.0, 1463.0, 748.0, 1489.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 2 \u9acb\u5173\u8282\u9aa8\u6027\u6807\u5fd7\uff08\u5de6\u4fa7\uff09""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +49,7,number,40,"[583.0, 1520.0, 608.0, 1539.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +49,8,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +50,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +50,1,paragraph_title,1.1.3 假体规划,"[224.0, 152.0, 397.0, 181.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1.3 \u5047\u4f53\u89c4\u5212""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +50,2,text,"充分评估患者双下肢长度差异(骨性长度差和外观长度差)、髋臼包容性、髋臼骨质情况、股骨髓腔形状、髓腔大小及股骨偏心距等。根据比例尺选用厂家透明模板进行模板规划。髋臼假体要求 $ ^{[13,14]} $:①髋臼杯下缘要求与泪滴下缘平行。②髋臼杯内侧缘距离泪滴外侧缘5—10mm,位于髂坐线上,杯外侧缘超过髋臼上缘骨质,适当保留软骨下骨,保证假体覆盖率。股骨假体要求:①根据股骨髓腔形状选择合适假体类型。","[175.0, 199.0, 1015.0, 557.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +50,3,text,据相关研究表明,二维模板规划精准预测髋臼假体准确率为25%—85.7%,股骨假体的准确率为32%—49.15%,预测髋臼假体在一个尺寸内的准确率为45%—89.3%,而股骨假体准确率为60.7%—83.6% $ ^{[6]} $,股骨柄的准确率略高于髋臼杯。随着科学技术的发展,各种辅助手术技术被应用在髋关节置换中。尽管有不同方式选择,由于二维规划的简便性,目前仍被广泛使用。由于髋关节是3D结构,2,"[175.0, 574.0, 1016.0, 1307.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +50,4,paragraph_title,1.2 三维模板测量法,"[225.0, 1374.0, 506.0, 1408.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2 \u4e09\u7ef4\u6a21\u677f\u6d4b\u91cf\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +50,5,text,数字化技术在医学领域已广泛应用,对 THA 也有着重要的影响,尤其是在术前规划方面,利用数字化模板进行术前测量显示出独特的优势 $ ^{[18]} $。THA 预测,"[175.0, 1431.0, 1015.0, 1508.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +50,6,number,41,"[583.0, 1522.0, 606.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +50,7,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +51,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +51,1,text,的准确性提高得益于术前规划从二维到三维的转变。髋关节 x 线片由于二维投照的限制,无法反应骨盆倾斜程度、股骨前倾角、股骨颈干角、股骨前弓等信息。而三维成像很好地解决了这些问题 $ ^{[19]} $。三维模板测量法简单来说,就是将患者髋关节 CT 资料通过处理软件转化为虚拟三维模型并进行手术设计及规划。操作要求如下述:,"[175.0, 152.0, 1014.0, 368.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,2,paragraph_title,1.2.1 CT 扫描要求,"[224.0, 385.0, 434.0, 414.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 1.2.1 CT \u626b\u63cf\u8981\u6c42""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +51,3,text,螺旋 CT 对髋关节进行扫描,范围包括骨盆、骶尾骨、双侧股骨近端 1/2,如患者出现股骨畸形、脊柱侧弯或骨盆倾斜等情况,可以适当扩大 CT 扫描范围。目前三维规划软件对扫面层厚要求不一,一般选择 1mm 层厚。完成髋关节 CT 后,将患者数据以 DICOM 格式保存备用。,"[177.0, 433.0, 1015.0, 604.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,4,paragraph_title,1.2.2 三维规划软件分类,"[224.0, 620.0, 501.0, 649.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2.2 \u4e09\u7ef4\u89c4\u5212\u8f6f\u4ef6\u5206\u7c7b""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +51,5,text,目前用于手术规划的处理软件主要分为三类:第一,商业软件,如比利时materialise开发的MIMICS系统使用较为广泛、功能相对全面 $ ^{[20]} $,同时在图像解剖分析和创建精准的数字化3D模型的基础上还能规划手术过程。第二,其他软件,如Analyze、3D-DOCTOR、SimPlant和SurgiCase等,这些软件主要用于处理图像数据、3D分析、设计或进行3D模型的打印 $ ^{[,"[174.0, 667.0, 1015.0, 1025.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,6,paragraph_title,1.2.3 三维规划过程,"[224.0, 1041.0, 446.0, 1070.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2.3 \u4e09\u7ef4\u89c4\u5212\u8fc7\u7a0b""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +51,7,text,将患者的 DICOM 格式数据将其导入规划软件行三维重建。同时在计算机中进行髋关节三维动态重建,了解髋关节损伤及分型。在三维模型上标定髋关节相应识别点。在此模型的基础上根据术者的计划进行截骨、假体放置等数字化模拟步骤,根据其模拟结果选定合适尺寸的假体 $ ^{[24]} $。,"[175.0, 1088.0, 1013.0, 1259.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,8,text,目前,国内外在三维规划上已经有相当的应用并取得了一定的研究结果,结果均显示三维模板规划优于二维模板。M. Viceconti $ ^{[25]} $等研究发现,使用 Hip-OP三维模板系统后,将二维模板法的髋臼杯和股骨柄的准确度从83%与69%提升至86%与93%。Sugano $ ^{[26]} $等人也提示了,当股骨颈前倾和髋关节外旋超过15°,二维规划无法满足THA的术前规划,并且三维规划,"[175.0, 1275.0, 1014.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,9,number,42,"[583.0, 1521.0, 607.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +51,10,footer,中国知网 https://www.cnki.net,"[38.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +52,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +52,1,text,二维规划。但 Jurik $ ^{[27]} $等提出,单次螺旋 CT 扫描相当于进行 4 次髋关节 X 线片,他们对辐射量表示担忧。除此之外,Habeeb $ ^{[28]} $等也发现,三维规划与相关成本较高可能会阻碍三维规划的推广,但他们认为,与 2D 模板相比,3D 模板能更精准的规划 THA。并且,同时还证明 3D 模板方式具有足够的可靠性和可重复性。因此,三维模板临床上的可使用性需要进,"[175.0, 151.0, 1014.0, 370.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,2,paragraph_title,1.3 人工智能规划,"[225.0, 437.0, 475.0, 472.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.3 \u4eba\u5de5\u667a\u80fd\u89c4\u5212""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +52,3,text,近年来人工智能在生物医学研究和临床实践中发挥着越来越大的作用,在风险建模、个性化筛查、疾病诊断以及治疗效应的预测和预后等方面都显示了巨大的潜在应用价值 $ ^{[29]} $。人工智能是用计算机控制机器模拟类似人类的智能过程,它包括信息、推理和自我纠正能力,它可以帮助外科医生提供有效的治疗和个性化的体验 $ ^{[30]} $。人工智能可以分析通过各种放射技术获得的数字形式的数据,如 X 线照片、,"[174.0, 495.0, 1015.0, 807.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,4,text,随着人工智能技术的发展,运用 AI 技术进行髋关节疾病识别及诊断,髋部骨骼的三维成像,智能规划手术方案变得可行。吴东 $ ^{[31]} $等验证了 AI-HIP 系统(北京长木古有限公司)的有效性及准确性。丁冉 $ ^{[32]} $等对 32 例行初次全髋关节置换患者接受传统模板与人工智能术前规划方式进行比较发现,人工智能不仅假体大小及位置规划准确度优于传统模板组,而且规划时间明显短于传统模板,"[174.0, 823.0, 1015.0, 1089.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,5,paragraph_title,1.4 手术机器人,"[224.0, 1155.0, 445.0, 1190.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.4 \u624b\u672f\u673a\u5668\u4eba""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +52,6,text,"工业中,机器人技术是一种完善的优化流程和提高质量的方法。在关节外科领域,特别是全髋关节置换术中使用机器人的想法起源于20世纪90年代初的美国。1992年至1993年,ROBODOC手术机器人(Integrated Surgical Systems, Davis, California)经美国食品和药物管理局授权用于患者。1994年,这台机器人就已经在德国进行了4500多台髋关节置换术 $ ^{[3","[175.0, 1213.0, 1015.0, 1478.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,7,number,43,"[583.0, 1521.0, 608.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +52,8,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +53,0,header,海南医学院硕士学位论文,"[491.0, 85.0, 698.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +53,1,text,天玑(北京)以及和华(北京)等。,"[175.0, 151.0, 557.0, 181.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +53,2,text,机器人手术的关键仍然是术前规划,通过术前导入患者髋关节 CT 数据,虚拟形成髋关节 3D 模型,结合解剖数据和患者特定骨盆的参考点,并且在手术前进行视野验证 $ ^{[34]} $。机器人的规划软件为每个截骨面生成切割边界,每个边界由切割平面和切割平面与骨表面相交的二维轮廓组成。确保了机器人只能切割骨头,并防止其损伤周围的软组织。术中,医生通过特殊的标记导针标记相应的骨结构,机器人自动生成截骨平面,"[175.0, 199.0, 1015.0, 558.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +53,3,text,随着科技的进步,机器人在髋关节手术中的应用效果值得肯定,但这项技术也存在一些局限性。使用的主要限制与其成本效益与工程师依赖性相关。患者层面上来说,与可靠疗效相关的高额手术费用及使用费用增加了治疗负担。另外,在复杂髋关节或者发育异常的髋关节中,机器人无法精准识别髋关节骨性标志,将会直接影响髋臼假体位置的准确性 $ ^{[37]} $。,"[174.0, 573.0, 1014.0, 792.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +53,4,paragraph_title,2 总结与展望,"[223.0, 858.0, 408.0, 893.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2 \u603b\u7ed3\u4e0e\u5c55\u671b""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,True,True +53,5,text,术前规划由原来二维胶片向二维数字发展,到各类三维软件开发,然后到3D打印快速成型技术进行实物打印,使手术前的计划由二维变为三维,由平面走向立体,由静态走向动态。目前在骨科领域已经广泛应用于手术方案制定、个性化假体选择以及术后疗效观察等方面,并逐步向个体化方向转变。这样就便于骨科医生对形变复杂髋关节局部解剖及空间关系有一个直观认识,开展较全面术前评估,设计更为精准的术前计划,实践手术过程,最后获得了,"[174.0, 915.0, 1016.0, 1463.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +53,6,number,44,"[582.0, 1521.0, 608.0, 1538.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +53,7,footer,中国知网 https://www.cnki.net,"[37.0, 1621.0, 384.0, 1650.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +54,0,header,海南医学院硕士学位论文,"[492.0, 85.0, 697.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +54,1,paragraph_title,综述参考文献,"[493.0, 155.0, 696.0, 192.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u7efc\u8ff0\u53c2\u8003\u6587\u732e""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +54,2,reference_content,"[1]Bou M J, Parekh A, Osmani F, et al. Failed Total Hip Arthroplasty[J]. JBJS Rev, 2018,6(11):e3.","[191.0, 215.0, 1011.0, 289.0]",reference_item,0.85,"[""reference content label: [1]Bou M J, Parekh A, Osmani F, et al. Failed Total Hip Arth""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +54,3,reference_content,"[2]边焱焱, 程开源, 常晓, 等. 2011 至 2019 年中国人工髋膝关节置换手术量的初步统计与分析[J]. 中华骨科杂志, 2020(21): 1453-1460.","[191.0, 308.0, 1011.0, 385.0]",reference_item,0.85,"[""reference content label: [2]\u8fb9\u7131\u7131, \u7a0b\u5f00\u6e90, \u5e38\u6653, \u7b49. 2011 \u81f3 2019 \u5e74\u4e2d\u56fd\u4eba\u5de5\u9acb\u819d\u5173\u8282\u7f6e\u6362\u624b\u672f\u91cf\u7684\u521d\u6b65\u7edf\u8ba1\u4e0e\u5206\u6790[J]. \u4e2d""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +54,4,reference_content,"[3]Hu C Y, Yoon T R. Recent updates for biomaterials used in total hip arthroplasty[J]. 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项目得分项目得分
Ⅰ、疼痛2、功能活动
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THATotal", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:3", + "page": 5, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "中国知网 https://www.cnki.net", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:4", + "page": 5, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "1", + "found_in_fulltext": true, + "fulltext_offset": 458 + }, + { + "block_id": "p6:0", + "page": 6, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "海南医学院硕士学位论文", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:1", + "page": 6, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "人工智能辅助决策系统在髋关节置换术的临床应用研究", + "found_in_fulltext": true, + "fulltext_offset": 2 + }, + { + "block_id": "p6:2", + "page": 6, + "role": "sub_subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "摘要", + 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资料与方法", + "found_in_fulltext": true, + "fulltext_offset": 4563 + }, + { + "block_id": "p13:2", + "page": 13, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "1.1 纳入与排除标准", + "found_in_fulltext": true, + "fulltext_offset": 4575 + }, + { + "block_id": "p13:3", + "page": 13, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "(1) 纳入标准:", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p13:4", + "page": 13, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "① 患者具有髋关节置换手术适应证;", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p13:5", + "page": 13, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "② 首次进行髋关节置换的患者;", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p13:6", + "page": 13, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "③术前患者自愿签署知情同意书;", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p13:7", + "page": 13, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "④ 影像学资料完整;", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p13:8", + "page": 13, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "(2) 受试者排除标准;", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p13:9", + "page": 13, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "① 患者出现了肌萎缩、肌溶解或外展肌乏力等症状;", + "found_in_fulltext": true, + "fulltext_offset": 4587 + }, + { + "block_id": "p13:10", + "page": 13, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "② 患者有智力障碍或无法了解参加试验的必要性;", + "found_in_fulltext": true, + "fulltext_offset": 4612 + }, + { + "block_id": "p13:11", + "page": 13, + "role": 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Validation of CT-Based Three-Dimensional Preope", + "found_in_fulltext": true, + "fulltext_offset": 26612 + }, + { + "block_id": "p45:4", + "page": 45, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[50]赵移畛,杜天信,杨超凡. 3D骨科医患沟通系统临床应用效果评估:第三届中国中医药民族医药信息大会[C]. 中国内蒙古鄂尔多斯, 2016.", + "found_in_fulltext": true, + "fulltext_offset": 26821 + }, + { + "block_id": "p45:5", + "page": 45, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[51]贺宝华.术前谈话患者家属心理分析[J].医药论坛杂志,2003(08):75.", + "found_in_fulltext": true, + "fulltext_offset": 26383 + }, + { + "block_id": "p45:6", + "page": 45, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "36", + "found_in_fulltext": true, + "fulltext_offset": 5466 + }, + { + "block_id": "p45:7", + "page": 45, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "中国知网 https://www.cnki.net", + "found_in_fulltext": false, + 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Artificial Intelligence vs. Natural Stu", + "found_in_fulltext": true, + "fulltext_offset": 38128 + }, + { + "block_id": "p56:8", + "page": 56, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[31]吴东,刘星宇,张逸凌,等.人工智能辅助全髋关节置换术三维规划系统的研发及临床应用研究[J].中国修复重建外科杂志,2020,34(09):1077-10", + "found_in_fulltext": true, + "fulltext_offset": 37046 + }, + { + "block_id": "p56:9", + "page": 56, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[32]丁冉,王淇,刘烨,等.人工智能三维术前规划在全髋关节置换术中的应用和准确性分析[J].生物骨科材料与临床研究,2022,19(02):33-38.", + "found_in_fulltext": true, + "fulltext_offset": 37130 + }, + { + "block_id": "p56:10", + "page": 56, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[33]Bargar W L, Bauer A, Borner M. Primary and revision total hip replacement us", + "found_in_fulltext": true, + "fulltext_offset": 38313 + }, + { + "block_id": "p56:11", + "page": 56, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[34]Schneider J, Kalender W. Geometric accuracy in robot-assisted total hip repl", + "found_in_fulltext": true, + "fulltext_offset": 37208 + }, + { + "block_id": "p56:12", + "page": 56, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[35] Jakopec M, Harris S J, Rodriguez Y B F, et al. The first clinical applicati", + "found_in_fulltext": true, + "fulltext_offset": 38460 + }, + { + "block_id": "p56:13", + "page": 56, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "47", + "found_in_fulltext": true, + "fulltext_offset": 17273 + }, + { + "block_id": "p56:14", + "page": 56, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "中国知网 https://www.cnki.net", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p57:0", + "page": 57, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "海南医学院硕士学位论文", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p57:1", + "page": 57, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[36]Lecoanet P, Pascal G, Khaddad A, et al. Robot-assisted continent urinary div", + "found_in_fulltext": true, + "fulltext_offset": 38648 + }, + { + "block_id": "p57:2", + "page": 57, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[37]Kouyoumdjian P, Mansour J, Assi C, et al. Current concepts in robotic total ", + "found_in_fulltext": true, + "fulltext_offset": 38844 + }, + { + "block_id": "p57:3", + "page": 57, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "48", + "found_in_fulltext": true, + "fulltext_offset": 2307 + }, + { + "block_id": "p57:4", + "page": 57, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "中国知网 https://www.cnki.net", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p58:0", + "page": 58, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "海南医学院硕士学位论文", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p58:1", + "page": 58, + "role": "sub_subsection_heading", + "zone": "", + "render_default": true, + "snippet": "附录", + "found_in_fulltext": true, + "fulltext_offset": 38987 + }, + { + "block_id": "p58:2", + "page": 58, + "role": "subsection_heading", + "zone": "", + "render_default": true, + "snippet": "Harris 髋关节功能评分(百分制)", + "found_in_fulltext": true, + "fulltext_offset": 38994 + }, + { + "block_id": "p58:3", + "page": 58, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "Harris 评分是一个广泛应用的评价髋关节功能的方法,常常用来评价保髋和关节置换的效果。满分 100 分,90 分以上为优良,80-89 分为较好,70-79", + "found_in_fulltext": true, + "fulltext_offset": 39014 + }, + { + "block_id": "p58:4", + "page": 58, + "role": "media_asset", + "zone": "", + "render_default": true, + "snippet": "
组别n术后1月(分)术后3月(分)术后6月(分)
项目得分项目得分
Ⅰ、疼痛
DrugsMechanismFunctionRef.
DADSIncrease Nrf2 nuclear translocation and gene expressions of antioxidant enzymesReduce the pr,"[68.0, 782.0, 1123.0, 1376.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +7,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 259.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,7 of 25,"[1068.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,2,figure_title,Table 2. Classifications and biological functions of polyphenol in osteoarthritis.,"[326.0, 192.0, 963.0, 215.0]",table_caption,0.9,"[""table prefix matched: Table 2. Classifications and biological functions of polyphe""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +7,3,table,"
DrugsMechanismFunctionRef.
EGCGDecrease the expressions of mTORReduce the chondrocyte apoptosis and activate au","[69.0, 230.0, 1117.0, 690.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +7,4,paragraph_title,2.3. Chondrocyte Senescence and Mitochondrial Autophagy in Osteoarthritis,"[327.0, 722.0, 959.0, 746.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Chondrocyte Senescence and Mitochondrial Autophagy in O""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,5,text,"Recent research showed that cell studies and animal models point to aging-related and stress-induced oxidative stress as important factors related to chondrocyte senescence [82–84]. Senescent cells, w","[325.0, 752.0, 1125.0, 1206.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Autophagy is a cellular process regarded as a mechanism for cell survival when cells become stressed, degrading dysfunctional proteins and macromolecules, and then recycling them to produce materials ","[324.0, 1206.0, 1126.0, 1560.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 258.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 25,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,text,"treatment, Huang, H. T. et al. showed that $ (-) $-Epigallocatechin 3-gallate (EGCG), the most plentiful bioactive polyphenol of green tea with anti-arthritic, anti-inflammatory, and antioxidant effe","[326.0, 192.0, 1124.0, 369.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,paragraph_title,2.4. Chondrocyte Apoptosis and Calcium Homeostasis Regulation in Osteoarthritis,"[327.0, 387.0, 1008.0, 412.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Chondrocyte Apoptosis and Calcium Homeostasis Regulatio""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,4,text,Apoptosis is the most common form of cell death. It is characterized by a series of morphological and biochemical changes that lead to the formation of apoptotic bodies that are phagocytosed by macrop,"[325.0, 418.0, 1124.0, 771.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"There are a large number of apoptotic chondrocytes in OA cartilage, and mitochondrial-induced chondrocytes apoptosis is mediated by the reduction in $ \Delta\Psi_{m} $, overexpression of ROS, mechani","[326.0, 770.0, 1124.0, 1097.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"The calcium ion (Ca²⁺), one of the most important intracellular second messengers, is responsible for biological functions, such as cell adhesion, metabolism, secretion, proliferation, and apoptosis [","[325.0, 1097.0, 1125.0, 1423.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,text,"Under physiological cell stress, mitochondria can take up $ Ca^{2+} $ from cytosolic $ Ca^{2+} $ or the ER, and store it transiently to maintain homeostasis and regulate mitochondrial function [105,","[325.0, 1422.0, 1125.0, 1549.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 258.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,9 of 25,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,text,and begin to shape $ Ca^{2+} $ dynamics [105]. Huser and Davies showed that impact-induced chondrocyte apoptosis and mitochondrial depolarization were significantly decreased when the amount of calci,"[326.0, 191.0, 1124.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"Several studies are concerned with drugs that focus on the mitochondrial apoptotic pathway, and these are listed in Tables 1 and 2. Shao, X. et al. showed that a lower range of the molecular weight of","[324.0, 442.0, 1125.0, 898.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,paragraph_title,2.5. mtDNA Haplogroups in Osteoarthritis,"[328.0, 914.0, 689.0, 939.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.5. mtDNA Haplogroups in Osteoarthritis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,5,text,"Mitochondria, which is well known as “maternal inheritance”, have their own genomic DNA [116]. Mitochondrial DNA (mtDNA) encodes 13 polypeptide subunits essential for the OXPHOS process, 2 ribosomal R","[326.0, 946.0, 1125.0, 1247.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,text,"In recent studies, European mtDNA haplogroup J was notably correlated with a decreased risk of knee OA in Spain [122,123], and individuals from the United Kingdom (UK) carrying the haplogroup T showed","[325.0, 1248.0, 1126.0, 1550.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"Biomedicines 2022, 10, 1477","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,10 of 25,"[1062.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,text,"There are different viewpoints to explain the associations between mtDNA haplogroups and OA. First, the associations could reside in the subtle functional differences between haplogroups, which eventu","[324.0, 192.0, 1125.0, 596.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,paragraph_title,3. AMPK and SIRT Pathway in Related to OA Pathogenesis,"[327.0, 613.0, 879.0, 637.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. AMPK and SIRT Pathway in Related to OA Pathogenesis""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +10,4,text,AMP-activated protein kinase (AMPK) and sirtuins (SIRT) are important biosensors that are activated in response to high AMP/ATP and ADP/ATP ratios [134]. AMPK activation restores ATP levels by inhibit,"[325.0, 645.0, 1125.0, 947.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"Sirtuins, which are a family of highly conserved protein modifying enzymes, detect fluctuations in the $ NAD^{+}/NADH $ ratio and regulate mitochondrial physiology and cell metabolism [140]. There ar","[325.0, 947.0, 1125.0, 1121.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"As mentioned above, AMPK and SIRT together regulate a variety of cellular physical activities. Here, we summarize the mechanism of action of AMPK and SIRT on ECM production, mitochondrial biogenesis, ","[324.0, 1122.0, 1125.0, 1298.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,paragraph_title,3.1. AMPK and SIRT Regulate ECM (Extracellular Matrix) Production and Mitochondrial Biogenesis in Chondrocytes,"[327.0, 1316.0, 1075.0, 1363.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. AMPK and SIRT Regulate ECM (Extracellular Matrix) Produ""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,8,text,"AMPK activation can increase ATP generation, which is beneficial for synthesizing ECM components. Some studies reported that physiological dynamic compression loading alters central metabolism in chon","[325.0, 1369.0, 1125.0, 1546.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,number,11 of 25,"[1062.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,text,"AMPK and SIRT regulate mitochondrial biosynthesis in chondrocytes via the AMPK-SIRT1/SIRT3-PCG-1α (peroxisome proliferator-activated receptor-γ coactivator 1 alpha) signaling pathway [147,148]. Wang e","[325.0, 192.0, 1125.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,3,text,"PGC-1α is a coactivator with nuclear respiratory factors (NRFs) in transcription and regulates the mitochondrial transcription factor A (TFAM), which is responsible for the mtDNA duplication, mitochon","[324.0, 444.0, 1125.0, 794.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"Some studies that focus on drugs targeting AMPK–SIRT pathways related to ECM production and mitochondrial biogenesis are shown in Tables 1 and 2. Dihydromyricetin (DHM), which has anti-inflammation an","[324.0, 794.0, 1126.0, 1175.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,paragraph_title,3.2. AMPK and SIRT Regulate Autophagy and Mitophagy in Chondrocytes,"[328.0, 1192.0, 950.0, 1216.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. AMPK and SIRT Regulate Autophagy and Mitophagy in Chond""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +11,6,text,"Autophagy is a conserved intracellular process that delivers cytoplasmic elements (e.g., proteins, organelles, and pathogens) to lysosomes for degradation via double-membrane autophagosomes [158]. On ","[325.0, 1223.0, 1124.0, 1347.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"Some studies reported that AMPK activates autophagy and mitophagy to remove damaged or defective mitochondria with impaired OXPHOS, whereas mTORC1, the mechanistic target of rapamycin complex 1, block","[326.0, 1348.0, 1125.0, 1551.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,0,header,"Biomedicines 2022, 10, 1477","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,12 of 25,"[1062.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,text,"TSC2 and the mTORC1 subunit RAPTOR, which results in reducing mTOR activity under conditions of energy stress and inhibiting the phosphorylation on ULK1 that activates autophagy [160,161]. Moreover, E","[324.0, 191.0, 1124.0, 419.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,text,"AMPK also directly regulates downstream mitophagy in chondrocytes via the SIRT1/SIRT3-FoxO3A-PINK1/Parkin signaling pathway, which is involved in clearing damaged mitochondria, limiting ROS production","[324.0, 417.0, 1125.0, 897.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,"Recent research has also reported that autophagy declines with age, which further leads to chondrocyte dysfunction and OA progression. Some studies have indicated that basal autophagy decreases with a","[325.0, 896.0, 1125.0, 1070.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"There are some potential drugs that focus on the AMPK–SIRT pathways related to mitophagy in OA chondrocytes, and these are shown in Tables 1 and 2. Huang, L. W. reported that zinc treatment ameliorate","[324.0, 1071.0, 1125.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,0,header,"Biomedicines 2022, 10, 1477","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,header,13 of 25,"[1062.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,2,paragraph_title,3.3. AMPK and SIRT Regulate Oxidative Stress and Inflammation Inhibition in Chondrocytes,"[326.0, 192.0, 1100.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. AMPK and SIRT Regulate Oxidative Stress and Inflammatio""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +13,3,text,"There is increasing evidence suggesting that AMPK and SIRT may be redox-sensing proteins in the management of ROS levels [135,174]. Some studies have indicated that AMPK and SIRT regulate chondrocyte ","[324.0, 223.0, 1125.0, 675.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"Apart from regulating oxidative stress, some studies also showed that AMPK and SIRT inhibit inflammation [70,140]. Salminen, A. and Kaarniranta, K. reported that inhibition of NF- $ \kappa $B signalin","[324.0, 676.0, 1124.0, 926.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,text,"Several research works discussed the drugs that focus on the AMPK–SIRT pathways related to oxidative stress regulation and inflammation inhibition in OA chondrocytes, as shown in Tables 1 and 2. Liu J","[325.0, 927.0, 1125.0, 1328.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,6,paragraph_title,4. Long Non-Coding RNA (lncRNA) and MicroRNA (miRNA) in Related to OA Pathogenesis,"[327.0, 1347.0, 1024.0, 1393.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Long Non-Coding RNA (lncRNA) and MicroRNA (miRNA) in Rela""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +13,7,text,"The human genome is estimated to consist of around 2% protein-coding RNA (pcRNA); however, the majority of the genome consists of non-coding RNA (ncRNA) [185]. The most common are tRNA, and rRNA, whic","[324.0, 1399.0, 1126.0, 1553.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 258.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,1,number,14 of 25,"[1062.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +14,2,text,"ogy, researchers have gradually discovered the important roles of long non-coding RNA (lncRNA) and MicroRNA (miRNA). Both lncRNA and miRNA are involved in important pathways related to OA pathogenesis","[325.0, 191.0, 1124.0, 294.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,3,paragraph_title,4.1. Relationship between lncRNA and OA Pathogenesis,"[327.0, 312.0, 796.0, 337.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.1. Relationship between lncRNA and OA Pathogenesis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +14,4,text,"LncRNA is an ncRNA that transcribes more than 200 nucleotides in length and modulates mRNA stability [188]. Previous studies have reported that, compared with healthy cartilage tissue, the expression ","[325.0, 344.0, 1126.0, 570.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,text,"Previous studies have shown that HOTAIR, which serves important for cancer progression, is expressed in normal human cartilage [190,191]. Research has also reported that HOTAIR and alpha-1, 2 fucosylt","[325.0, 570.0, 1125.0, 844.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,"MALAT1 is expressed in many tissues and participates in numerous biological processes $ [196] $. Zhang, Y. et al. reported that MALAT1 levels in OA cartilage were upregulated with AKT3 compared with ","[325.0, 846.0, 1125.0, 1146.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,text,"Regarding other lncRNAs involved in OA pathogenesis, Song, J. et al. reported that upregulated GAS5 levels in OA chondrocytes negatively regulated miR-21, which increased the expression of MMPs, stimu","[325.0, 1147.0, 1127.0, 1550.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,number,15 of 25,"[1061.0, 111.0, 1122.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +15,2,figure_title,Table 3. Classifications and biological functions of lncRNAs in osteoarthritis.,"[326.0, 192.0, 944.0, 215.0]",table_caption,0.9,"[""table prefix matched: Table 3. Classifications and biological functions of lncRNAs""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +15,3,table,"
lncRNATarget/Signaling PathwayFunctionRef.
HOTAIRFUT2/Wnt/ $ \beta $-cateninIncrease ECM degradation, chondrocy","[68.0, 230.0, 1117.0, 627.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +15,4,paragraph_title,4.2. Relationship between miRNA and OA Pathogenesis,"[327.0, 658.0, 791.0, 682.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2. Relationship between miRNA and OA Pathogenesis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +15,5,text,"In the pathogenesis of OA, miRNA has certain biological functions that mediate ECM metabolism, chondrocyte proliferation and apoptosis, and inflammatory responses. These are shown in Table 4 [208,209]","[324.0, 688.0, 1125.0, 1016.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,6,text,"Chondrocyte proliferation and apoptosis play a key role in OA pathogenesis, and many miRNAs regulate these important pathways. Research has demonstrated that miR-146a targets Smad4 to promote chondroc","[325.0, 1015.0, 1126.0, 1241.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,7,text,"Regarding the inflammatory response, previous studies revealed that several miRNAs are involved in inflammation regulation. Jones, S. revealed that miR-146, which is downregulated in OA cartilage, red","[326.0, 1241.0, 1127.0, 1492.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 259.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,1,number,16 of 25,"[1062.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +16,2,figure_title,Table 4. Classifications and biological functions of mi-RNAs in osteoarthritis.,"[326.0, 192.0, 947.0, 215.0]",table_caption,0.9,"[""table prefix matched: Table 4. Classifications and biological functions of mi-RNAs""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +16,3,table,"
mi-RNATarget/Signaling PathwayFunctionRef.
miR-483-5pMatn3Promote ECM degradation and chondrocyte h","[332.0, 228.0, 1118.0, 598.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +16,4,paragraph_title,5. Conclusions,"[328.0, 628.0, 471.0, 651.0]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +16,5,text,"In this review, we first presented evidence that mitochondria not only function as “energy powerhouses”, but also regulate several physiological activities of chondrocytes, including oxidative stress,","[323.0, 658.0, 1126.0, 1087.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,text,"Author Contributions: Conceptualization, H.-Y.L., C.-F.C., C.-C.L., S.-C.W., B.H., C.-W.W., L.K. and C.-H.C.; methodology, H.-Y.L., C.-F.C., C.-C.L., S.-C.W., B.H., T.-L.C., S.-Y.L., C.-J.H. and M.-J.","[325.0, 1108.0, 1126.0, 1321.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,support_like,none,True,True +16,7,text,"Funding: This study was supported in part by the National Health Research Institute (NHRI-EX101-9935EI) of Taiwan, Kaohsiung Medical University (NPUST-KMU-109-P002, NCTUKMU108-BIO-04, KMU-TC108A02-1, ","[325.0, 1331.0, 1125.0, 1522.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,0,header,"Biomedicines 2022, 10, 1477","[68.0, 111.0, 258.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,1,number,17 of 25,"[1062.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +17,2,text,"Acknowledgments: We appreciate the support from members of our orthopedic research center and the Department of Physiology, Kaohsiung Medical University, Kaohsiung City, Taiwan.","[326.0, 193.0, 1122.0, 241.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,3,text,"Conflicts of Interest: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the ma","[326.0, 251.0, 1123.0, 322.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +17,4,paragraph_title,References,"[68.0, 342.0, 176.0, 365.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +17,5,reference_content,"1. He, Y.; Wu, Z.; Xu, L.; Xu, K.; Chen, Z.; Ran, J.; Wu, L. The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis. Cell. Mol. Life Sci. 2020, 77, 3729–3743. [CrossRef] [PubMed]","[67.0, 372.0, 1123.0, 418.0]",reference_item,0.85,"[""reference content label: 1. 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Relationship between miRNA and OA Pathogenesis", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p15:5", + "page": 15, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In the pathogenesis of OA, miRNA has certain biological functions that mediate E", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p15:6", + "page": 15, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Chondrocyte proliferation and apoptosis play a key role in OA pathogenesis, and ", + "found_in_fulltext": true, + "fulltext_offset": 16883 + }, + { + "block_id": "p15:7", + "page": 15, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Regarding the inflammatory response, previous studies revealed that several miRN", + "found_in_fulltext": true, + "fulltext_offset": 17641 + }, + { + "block_id": "p16:0", + "page": 16, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Biomedicines 2022, 10, 1477", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p16:1", + "page": 16, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "16 of 25", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p16:2", + "page": 16, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 4. Classifications and biological functions of mi-RNAs in osteoarthritis.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p16:4", + "page": 16, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "5. Conclusions", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p16:5", + "page": 16, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In this review, we first presented evidence that mitochondria not only function ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p16:6", + "page": 16, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Author Contributions: Conceptualization, H.-Y.L., C.-F.C., C.-C.L., S.-C.W., B.H", + "found_in_fulltext": true, + "fulltext_offset": 18560 + }, + { + "block_id": "p16:7", + "page": 16, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Funding: This study was supported in part by the National Health Research Instit", + "found_in_fulltext": true, + "fulltext_offset": 19445 + }, + { + "block_id": "p17:0", + "page": 17, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Biomedicines 2022, 10, 1477", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p17:1", + "page": 17, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "17 of 25", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p17:2", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Acknowledgments: We appreciate the support from members of our orthopedic resear", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p17:4", + "page": 17, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p17:5", + "page": 17, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. 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"reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:1", + "p1:4", + "p1:15", + "p1:17", + "p1:18", + "p1:19", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:6", + "p2:7", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:6", + "p3:7", + "p4:0" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/3CEUN7T3/audit_report.md b/audit/3CEUN7T3/audit_report.md new file mode 100644 index 00000000..e46b7ee4 --- /dev/null +++ b/audit/3CEUN7T3/audit_report.md @@ -0,0 +1,38 @@ +# OCR Truth Audit Report - 3CEUN7T3 + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 5, 6, 7, 9] +- Reviewed blocks: 87 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/3CEUN7T3/audit_scope.json b/audit/3CEUN7T3/audit_scope.json new file mode 100644 index 00000000..3e88fff9 --- /dev/null +++ b/audit/3CEUN7T3/audit_scope.json @@ -0,0 +1,722 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 3, + 5, + 6, + 7, + 9 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p3:3", + "p3:14", + "p5:3", + "p5:10", + "p6:3", + "p6:7", + "p6:12", + "p7:5", + "p7:10", + "p7:12", + "p7:14", + "p7:15", + "p7:16", + "p7:17", + "p9:2", + "p9:3", + "p9:4", + "p9:5", + "p9:6", + "p9:7", + "p9:8" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:9", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:10", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:11", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:12", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:13", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:14", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:15", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:16", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:17", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:18", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:19", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:20", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:3", + "page": 3, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:14", + "page": 3, + "required_reason": [ + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p5:3", + "page": 5, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p5:10", + "page": 5, + "required_reason": [ + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, 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+++ b/audit/3CEUN7T3/block_trace.csv @@ -0,0 +1,172 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593 https://doi.org/10.1007/s00167-023-07508-7","[98.0, 64.0, 560.0, 109.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +1,1,text,SHOULDER,"[110.0, 129.0, 218.0, 151.0]",authors,0.6,"[""page-1 initial-lastname author byline: SHOULDER""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,2,image,,"[1030.0, 132.0, 1089.0, 190.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,3,doc_title,Gender and degree of tendon healing are independent predictive factors for clinical outcome in successfully healed rotator cuff tears,"[97.0, 209.0, 956.0, 280.0]",paper_title,0.8,"[""page-1 zone title_zone: Gender and degree of tendon healing are independent predicti""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,Koray Şahin $ ^{1} $ ☑. Muhammed Oğuzhan Albayrak $ ^{2} $ ☑. Fatih Şentürk $ ^{3} $ ☑. Mehmet Ersin $ ^{4} $ ☑. Ali Erşen $ ^{2} $,"[96.0, 313.0, 895.0, 339.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,5,text,Received: 30 March 2023 / Accepted: 5 July 2023 / Published online: 15 July 2023,"[97.0, 373.0, 629.0, 394.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 30 March 2023 / Accepted: 5 July 2023 / Published ""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,6,text,"© The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2023","[96.0, 395.0, 918.0, 416.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 The Author(s) under exclusive licence to European Society ""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,7,paragraph_title,Abstract,"[97.0, 450.0, 183.0, 472.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,body_zone,heading_like,short_fragment,True,True +1,8,abstract,urpose Arthroscopic rotator cuff repair (aRCR) is a commonly performed procedure and has been reported to be a success l treatment. Successful healing has traditionally been considered to be associate,"[119.0, 475.0, 1081.0, 578.0]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,9,abstract,Methods This retrospective case–control study was conducted in a single center with 135 patients who had successfully healed tendons based on Sugaya classification (grades I–III) on postoperative magn,"[96.0, 576.0, 1094.0, 699.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,10,abstract,"Results Mean age of patients was $ 55.9 \pm 9.0 $ years and mean follow-up duration was $ 46.8 \pm 14.9 $ months. There were 50 (37%) male and 85 (63.0%) female patients. At final follow-up, mean CM","[96.0, 701.0, 1094.0, 925.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,11,abstract,"Conclusions This study showed that despite achieving a successful healing, considerable amount of patients (17.8%) have ended up with poor outcome. Female gender and degree of tendon healing were iden","[96.0, 926.0, 1094.0, 1024.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,12,text,Keywords Rotator cuff tear · Rotator cuff healing · Predictive factor · Outcome,"[96.0, 1051.0, 734.0, 1076.0]",structured_insert,0.7,"[""frontmatter noise text: Keywords Rotator cuff tear \u00b7 Rotator cuff healing \u00b7 Predicti""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,13,paragraph_title,Introduction,"[608.0, 1124.0, 750.0, 1149.0]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,14,footnote,"☒ Koray Şahin +drkoraysahin@gmail.com","[97.0, 1184.0, 311.0, 1228.0]",footnote,0.7,"[""footnote label: \u2612 Koray \u015eahin\ndrkoraysahin@gmail.com""]",footnote,0.7,body_zone,body_like,none,True,True +1,15,footnote," $ ^{1} $ Department of Orthopedics and Traumatology, Bezmialem Vakif University, Istanbul, Turkey","[97.0, 1244.0, 540.0, 1287.0]",footnote,0.7,"[""footnote label: $ ^{1} $ Department of Orthopedics and Traumatology, Bezmial""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,16,text,Rotator cuff disease is the main cause of admission to primary care due to shoulder pain and dysfunction [14]. Non-operative management is the first line of treatment recommended for majority of sympt,"[604.0, 1176.0, 1094.0, 1427.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,footnote," $ ^{2} $ Department of Orthopedics and Traumatology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey","[96.0, 1294.0, 527.0, 1338.0]",footnote,0.7,"[""footnote label: $ ^{2} $ Department of Orthopedics and Traumatology, Istanbu""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,18,footnote," $ ^{3} $ Department of Orthopedics and Traumatology, Hendek State Hospital, Sakarya, Turkey","[97.0, 1345.0, 548.0, 1387.0]",footnote,0.7,"[""footnote label: $ ^{3} $ Department of Orthopedics and Traumatology, Hendek ""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,19,footnote," $ ^{4} $ Department of Orthopedics and Traumatology, Istanbul Haseki Training and Research Hospital, Istanbul, Turkey","[96.0, 1394.0, 521.0, 1438.0]",footnote,0.7,"[""footnote label: $ ^{4} $ Department of Orthopedics and Traumatology, Istanbu""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,20,footer_image,,"[1002.0, 1470.0, 1091.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,0,number,4586,"[99.0, 63.0, 138.0, 82.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[627.0, 62.0, 1092.0, 84.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,2,text,"conservative management is associated with increase in tear size and inferior outcomes in long term [26]. Therefore, aRCR has been reported to be a successful treatment with significant pain relief an","[95.0, 113.0, 582.0, 238.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Previous outcome studies reported significant correlation between successful healing of the repaired cuff and good clinical outcomes [15, 16, 22, 28, 38]. Achieving complete structural integrity of th","[96.0, 239.0, 583.0, 713.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,The purpose of this study is to evaluate patients with successfully healed tendons following aRCR and to determine predictive factors causing poor final outcome in this specific patient group. It has ,"[95.0, 714.0, 582.0, 864.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,paragraph_title,Materials and methods,"[97.0, 911.0, 350.0, 937.0]",section_heading,0.9,"[""explicit scholarly heading: Materials and methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,6,text,"Institutional review board approval (E-67690154-050.03.04-1110453) was obtained from Istanbul University Istanbul Faculty of Medicine, and written inform consents were obtained from all included patie","[95.0, 962.0, 582.0, 1214.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,Patient selection,"[97.0, 1237.0, 259.0, 1261.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Patient selection""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,8,text,"Records of 454 patients who underwent aRCR procedure during study period by the senior author were reviewed. Surgery was indicated in case of persistent pain, discomfort or shoulder dysfunction despit","[95.0, 1288.0, 582.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"and rehabilitation. All decisions for surgery were given by +the senior author with preoperative clinical evaluation and +confirmation of presence of a full-thickness RCT using pre- +operative magnetic r","[604.0, 113.0, 1093.0, 213.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,"Inclusion criteria were (1) full-thickness RCT treated with transosseous equivalent (TOE) aRCR technique, (2) presence of a structural outcome data of the repair using postoperative MRI scans obtained","[604.0, 214.0, 1094.0, 587.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,text,"Records of 454 patients who underwent aRCR during study period were evaluated and 354 patients met the inclusion criteria. Among these 354 patients, 52 patients had subscapularis tears, 76 patients ha","[605.0, 588.0, 1093.0, 915.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,paragraph_title,Surgical procedure,"[607.0, 937.0, 789.0, 963.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Surgical procedure""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,13,text,"All surgeries were performed by the senior author with patients positioned in beach chair position under general anaesthesia. Following diagnostic arthroscopy through standard posterior portal, tenoto","[604.0, 988.0, 1093.0, 1263.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,text,A knotless TOE aRCR repair was then performed using a previously described technique [33]. Tear size was taken into consideration in order to determine number of medial row anchors. One anchor (Healic,"[604.0, 1264.0, 1095.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,footer_image,,"[99.0, 1470.0, 189.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[97.0, 62.0, 561.0, 84.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +3,1,number,4587,"[1053.0, 63.0, 1091.0, 82.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,figure_title,"Table 1 Preoperative demographic, clinical and intraoperative data of patients (data are reported as mean ± standard deviation or n (%))","[97.0, 112.0, 303.0, 235.0]",table_caption,0.9,"[""table prefix matched: Table 1 Preoperative demographic, clinical and intraoperativ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,3,table,"
Preoperative demographic, clinical and operative variable (n = 135)Data
GenderMale 50 (37.0), female 85 (63.0)
Age (years)55","[348.0, 114.0, 1090.0, 527.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,4,vision_footnote,"BMI body mass index, CMS Constant–Murley score, LHBT long head of biceps tendon","[352.0, 539.0, 953.0, 563.0]",footnote,0.7,"[""vision_footnote label: BMI body mass index, CMS Constant\u2013Murley score, LHBT long he""]",footnote,0.7,body_zone,body_like,none,True,True +3,5,text,small tears and two anchors for medium-sized tears. Repair was completed using one knotless lateral row anchor (Footprint PK; Smith&Nephew).,"[95.0, 610.0, 583.0, 688.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,Postoperative rehabilitation,"[97.0, 709.0, 363.0, 736.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Postoperative rehabilitation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,7,text,All patients underwent same standardized postoperative protocol and were followed up by the same physiotherapist starting from 1st postoperative day. All patients were immobilized for 4 weeks using an,"[95.0, 760.0, 583.0, 1088.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,paragraph_title,Clinical variables and patient assessment,"[97.0, 1109.0, 480.0, 1135.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical variables and patient assessment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,9,text,"All patients underwent preoperative clinical evaluation 1 day before the surgery by the first author. Postoperative clinical evaluations were also performed by the same author at 2 weeks, 6 weeks, 3 m","[95.0, 1160.0, 583.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"group (group II) consisted of patients with postoperative +CMS > 75. The cutoff score of 75 points was determined +according to the reported minimal clinical important dif- +ference (MCID) of CMS which i","[604.0, 611.0, 1093.0, 787.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,text,Other clinical outcome measures included pain score and ROM measurements. Pain score was assessed using a visual analogue scale (VAS) in a 10 points scale with 0 point indicating no pain and 10 points,"[604.0, 787.0, 1095.0, 1211.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,paragraph_title,Radiologic assessment,"[607.0, 1235.0, 823.0, 1260.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Radiologic assessment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,13,text,All included patients underwent preoperative MRI to confirm full-thickness RCT diagnosis and to evaluate tear characteristics and also postoperative MRI at a mean of $ 13.0 \pm 2.1 $ months in order ,"[604.0, 1286.0, 1095.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,footer_image,,"[1002.0, 1471.0, 1091.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +4,0,number,4588,"[99.0, 63.0, 138.0, 81.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[627.0, 62.0, 1092.0, 84.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +4,2,text,classification described by DeOrio and Cofield [8]. Patte classification [30] was used on preoperative T2-weighted coronal oblique images in order to assess tear retraction. Degree of fatty infiltrati,"[96.0, 111.0, 582.0, 536.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"All MRI scans were obtained using a 1.5-Tesla magnetic resonance unit (Magnetom Aera, Siemens) equipped with a dedicated shoulder coil with upper extremity positioned in neutral position. Axial, sagit","[95.0, 536.0, 583.0, 788.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,Statistical analysis,"[97.0, 810.0, 274.0, 835.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,5,text,"Descriptive statistical methods used in order to analyze study data were mean, median, standard deviation, range, frequency and percentage. Normality distribution of continuous variables was performed","[95.0, 861.0, 582.0, 1161.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,A multivariate logistic regression analysis was conducted with statistically significant factors which were observed in the univariate analysis in order to determine independent predictive factors for,"[95.0, 1162.0, 583.0, 1361.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"Post hoc power analysis of the logistic regression model was performed using the rule of thumb of “events per variable” (EPV). Historically, ten events per variable were suggested to reach the necessa","[95.0, 1362.0, 583.0, 1436.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"suggested to reach the necessary power in logistic regression +models [32]. However, recent statistical knowledge suggests +that rule of ten EPV can be relaxed in case of results from +any logistic model","[605.0, 112.0, 1093.0, 261.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,Number of independent variables was kept minimum in the logistic regression model by performing a univariate analysis and by eliminating irrelevant covariates which gave the statistical advantage to t,"[605.0, 263.0, 1095.0, 563.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,paragraph_title,Results,"[607.0, 633.0, 694.0, 660.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,11,text,"Comparisons of preoperative clinical outcome measures including ROM, functional score and pain score between two study groups showed that two study groups were comparable preoperatively (n.s.). Group ","[604.0, 687.0, 1094.0, 1036.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,"Possible predictive factors affecting final clinical outcome were evaluated in a univariate analysis (Table 3). It was observed that gender, body mass index (BMI) and postoperative structural outcome ","[605.0, 1037.0, 1093.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,footer_image,,"[99.0, 1470.0, 189.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[98.0, 62.0, 561.0, 84.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +5,1,number,4589,"[1053.0, 63.0, 1091.0, 81.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,figure_title,Table 2 Preoperative and postoperative clinical outcome data of study groups,"[97.0, 111.0, 314.0, 175.0]",table_caption,0.9,"[""table prefix matched: Table 2 Preoperative and postoperative clinical outcome data""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,3,table,"
Group I (poor outcome, n=24)Group II (good outcome, n=111)p valueMean or median difference (95% CI)
Abduction, degrees
Group I (poor outcome, n=24)Group II (good outcome, n=111)p valueMean or median difference (95% CI)Odds ratio (95% CI)
Gend","[96.0, 118.0, 1088.0, 804.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,vision_footnote,Data reported as mean ± standard deviation or n (%). Bolded p values indicate statistical significance,"[97.0, 815.0, 790.0, 838.0]",footnote,0.7,"[""vision_footnote label: Data reported as mean \u00b1 standard deviation or n (%). Bolded ""]",footnote,0.7,body_zone,body_like,none,True,True +6,5,vision_footnote,"BMI body mass index, CMS Constant–Murley score, VAS visual analogue scale, LHBT long head of biceps tendon, CI confidence interval, n.s. non-significant. $ {}^{a} $Chi-square test, $ {}^{b} $Mann–Wh","[96.0, 842.0, 1091.0, 885.0]",footnote,0.7,"[""vision_footnote label: BMI body mass index, CMS Constant\u2013Murley score, VAS visual a""]",footnote,0.7,body_zone,body_like,none,True,True +6,6,figure_title,Table 4 Multivariate logistic regression analysis of predictive factors associated with poor clinical outcome (bolded p values indicate statistical significance),"[97.0, 938.0, 582.0, 1001.0]",table_caption,0.9,"[""table prefix matched: Table 4 Multivariate logistic regression analysis of predict""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,7,table,
VariableOdds ratio95% CIp value
Gender (female)3.651.13-14.70.04
BMI1.070.96-1.,"[98.0, 1008.0, 578.0, 1175.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,8,vision_footnote,"BMI body mass index, CI confidence interval, n.s. non-significant","[97.0, 1188.0, 552.0, 1211.0]",footnote,0.7,"[""vision_footnote label: BMI body mass index, CI confidence interval, n.s. non-signif""]",footnote,0.7,body_zone,body_like,none,True,True +6,9,text,"Consistent to these data, it was showed by the findings of the present study that female gender was an independent predictive factor for poor clinical outcome in patients with healed RCTs. Some possib","[95.0, 1261.0, 583.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"dressing, and that women might have different subjective +symptom perception compared to men.","[606.0, 936.0, 1092.0, 986.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,text,Findings of the present study showed that second independent predictive factor affecting final outcome was the degree of tendon healing. Even though grade I and II healing according to Sugaya classifi,"[604.0, 987.0, 1094.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,12,footer_image,,"[99.0, 1470.0, 189.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +7,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[97.0, 62.0, 561.0, 84.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,1,number,4591,"[1053.0, 64.0, 1090.0, 82.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,showed that higher signal intensity of the repaired tendon on postoperative MRI scans was significantly higher in patients with residual pain and that there was a significant association between pain ,"[96.0, 112.0, 583.0, 386.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,Obesity has been recently reported as a risk factor for poor healing of RCTs $ [10] $ and as negative contributor to recovery following aRCR $ [37] $ considering higher risk of anesthesia-related co,"[96.0, 387.0, 583.0, 636.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"Determination of all contributors to clinical outcome is difficult since it is affected by numerous factors. The present study mainly focused on several physical factors; however, it is obvious that p","[96.0, 637.0, 582.0, 961.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,This study has several limitations that need to be noted. Retrospective nature of the study is the first limitation that should be mentioned which may have cause selection bias and other unanticipated,"[96.0, 963.0, 583.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,6,text,"Another limitation is that type of diabetes and level of gly- +cemic control data which are potentially important for our +results were not available for analysis. This variable was +evaluated only relyi","[605.0, 111.0, 1093.0, 210.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"This study also has some strength that needs to be mentioned. Compared to similar studies on this topic [27], the study was conducted in a single center and all patients were operated by a single surg","[605.0, 213.0, 1094.0, 563.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,Conclusion,"[608.0, 634.0, 734.0, 660.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +7,9,text,"This study showed that despite successful healing of repaired tendon confirmed on postoperative MRI scans, 17.8% of the patients experienced poor clinical outcomes. Female gender and the degree of ten","[605.0, 686.0, 1093.0, 889.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,Funding No funding was received for this study.,"[606.0, 928.0, 948.0, 951.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,paragraph_title,Declarations,"[608.0, 970.0, 732.0, 994.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Declarations""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +7,12,text,Conflict of interest None.,"[607.0, 1013.0, 790.0, 1035.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +7,13,text,Ethical approval IRB approval was obtained from institutional review board of Istanbul University Istanbul Faculty of Medicine with IRB ID number: E-67690154-050.03.04-1110453.,"[606.0, 1053.0, 1092.0, 1116.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,14,paragraph_title,References,"[609.0, 1198.0, 734.0, 1224.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +7,15,reference_content,"1. 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J Bone Jt Surg Am 82(3):304–314","[100.0, 1353.0, 582.0, 1411.0]",reference_item,0.85,"[""reference content label: 20. Jost B, Pfirrmann CW, Gerber C, Switzerland Z (2000) Cli""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,20,reference_content,"21. Kukkonen J, Kauko T, Vahlberg T, Joukainen A, Aärimaa V (2013) Investigating minimal clinically important difference for Constant score in patients undergoing rotator cuff surgery. J Shoulder Elbo","[609.0, 112.0, 1092.0, 190.0]",reference_item,0.85,"[""reference content label: 21. Kukkonen J, Kauko T, Vahlberg T, Joukainen A, A\u00e4rimaa V ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,21,reference_content,"22. Li H, Chen Y, Chen S (2019) Postoperative residual pain is associated with a high magnetic resonance imaging (MRI)-based signal intensity of the repaired supraspinatus tendon. Knee Surg Sports Tra","[610.0, 192.0, 1091.0, 270.0]",reference_item,0.85,"[""reference content label: 22. Li H, Chen Y, Chen S (2019) Postoperative residual pain ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,22,reference_content,"23. Longo UG, Risi Ambrogioni L, Candela V, Berton A, Carnevale A, Schena E et al (2021) Conservative versus surgical management for patients with rotator cuff tears: a systematic review and META-anal","[609.0, 272.0, 1091.0, 369.0]",reference_item,0.85,"[""reference content label: 23. Longo UG, Risi Ambrogioni L, Candela V, Berton A, Carnev""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,23,reference_content,"24. Maher A, Leigh W, Young S, Caughey W, Hoffman T, Brick M et al (2022) Do age, demographics, and tear characteristics affect outcomes after rotator cuff repair? Results of over 2000 rotator cuff re","[610.0, 372.0, 1091.0, 488.0]",reference_item,0.85,"[""reference content label: 24. Maher A, Leigh W, Young S, Caughey W, Hoffman T, Brick M""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True +8,24,reference_content,"25. Mall NA, Tanaka MJ, Choi LS, Paletta GA (2014) Factors affecting rotator cuff healing. J Bone Jt Surg Am 96(9):778–788","[610.0, 492.0, 1092.0, 530.0]",reference_item,0.85,"[""reference content label: 25. Mall NA, Tanaka MJ, Choi LS, Paletta GA (2014) Factors a""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,25,reference_content,"26. Moosmayer S, Lund G, Seljom US, Haldorsen B, Svege IC, Hennig T et al (2014) Tendon repair compared with physiotherapy in the treatment of rotator cuff tears: a randomized controlled study in 103 ","[610.0, 533.0, 1091.0, 629.0]",reference_item,0.85,"[""reference content label: 26. Moosmayer S, Lund G, Seljom US, Haldorsen B, Svege IC, H""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,26,reference_content,"27. Nabergoj M, Bagheri N, Bonnevialle N, Gallinet D, Barth J, Labattut L et al (2021) Arthroscopic rotator cuff repair: is healing enough? Orthop Traumatol Surg Res 107(8S):103100. https://doi.org/10","[610.0, 632.0, 1091.0, 710.0]",reference_item,0.85,"[""reference content label: 27. Nabergoj M, Bagheri N, Bonnevialle N, Gallinet D, Barth ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,27,reference_content,"28. Noyes MP, Ladermann A, Denard PJ (2019) Functional outcome and healing with a load-sharing rip-stop repair compared with a single-row repair for large and massive rotator cuff tears. Arthroscopy 3","[611.0, 712.0, 1090.0, 790.0]",reference_item,0.85,"[""reference content label: 28. Noyes MP, Ladermann A, Denard PJ (2019) Functional outco""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,28,reference_content,"29. Paloneva J, Lepola V, Aärimaa V, Joukainen A, Ylinen J, Mattila VM (2015) Increasing incidence of rotator cuff repairs—a nationwide registry study in Finland. BMC Musculoskelet Disord 16:189. http","[610.0, 793.0, 1091.0, 869.0]",reference_item,0.85,"[""reference content label: 29. Paloneva J, Lepola V, A\u00e4rimaa V, Joukainen A, Ylinen J, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,29,reference_content,30. Patte D (1990) Classification of rotator cuff lesions. Clin Orthop Relat Res 254:81–86,"[610.0, 872.0, 1090.0, 910.0]",reference_item,0.85,"[""reference content label: 30. Patte D (1990) Classification of rotator cuff lesions. C""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,30,reference_content,"31. Paul S, Goyal T, Yadav AK (2022) Association between functional outcome scores and MRI-based structural integrity after rotator cuff repair: a prospective cohort study. Arch Orthop Trauma Surg 142","[611.0, 912.0, 1091.0, 990.0]",reference_item,0.85,"[""reference content label: 31. Paul S, Goyal T, Yadav AK (2022) Association between fun""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,31,reference_content,"32. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49(12):1373–1379","[610.0, 992.0, 1091.0, 1069.0]",reference_item,0.85,"[""reference content label: 32. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,32,reference_content,"33. Şahin K, Şentürk F, Ersin M, Arzu U, Chodza M, Erşen A (2021) Repair integrity and functional outcomes between knot-tying and knotless suture-bridge arthroscopic rotator cuff repair: a prospective","[611.0, 1072.0, 1091.0, 1188.0]",reference_item,0.85,"[""reference content label: 33. \u015eahin K, \u015eent\u00fcrk F, Ersin M, Arzu U, Chodza M, Er\u015fen A (""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,33,reference_content,"34. Sugaya H, Maeda K, Matsuki K, Moriishi J (2007) Repair integrity and functional outcome after arthroscopic double-row rotator cuff repair. A prospective outcome study. J Bone Jt Surg Am. 89(5):953","[609.0, 1192.0, 1090.0, 1269.0]",reference_item,0.85,"[""reference content label: 34. Sugaya H, Maeda K, Matsuki K, Moriishi J (2007) Repair i""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,34,reference_content,"35. Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165(6):710–718","[611.0, 1272.0, 1090.0, 1330.0]",reference_item,0.85,"[""reference content label: 35. Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,35,reference_content,"36. Voigt C, Bosse C, Vosshenrich R, Schulz AP, Lill H (2010) Arthroscopic supraspinatus tendon repair with suture-bridging technique: functional outcome and magnetic resonance imaging. Am J Sports Me","[610.0, 1333.0, 1091.0, 1410.0]",reference_item,0.85,"[""reference content label: 36. 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Warrender WJ, Brown OL, Abboud JA (2011) Outcomes of art""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,3,reference_content,"38. Wylie JD, Baran S, Granger EK, Tashjian RZ (2018) A comprehensive evaluation of factors affecting healing, range of motion, strength, and patient-reported outcomes after arthroscopic rotator cuff ","[101.0, 174.0, 580.0, 270.0]",reference_item,0.85,"[""reference content label: 38. Wylie JD, Baran S, Granger EK, Tashjian RZ (2018) A comp""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,4,reference_content,"39. Wylie JD, Suter T, Potter MQ, Granger EK, Tashjian RZ (2016) Mental health has a stronger association with patient-reported shoulder pain and function than tear size in patients with full-thicknes","[101.0, 273.0, 580.0, 351.0]",reference_item,0.85,"[""reference content label: 39. 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Howev", + "found_in_fulltext": true, + "fulltext_offset": 11553 + }, + { + "block_id": "p4:9", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Number of independent variables was kept minimum in the logistic regression mode", + "found_in_fulltext": true, + "fulltext_offset": 11952 + }, + { + "block_id": "p4:10", + "page": 4, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Results", + "found_in_fulltext": true, + "fulltext_offset": 908 + }, + { + "block_id": "p4:11", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Comparisons of preoperative clinical outcome measures including ROM, functional ", + "found_in_fulltext": true, + "fulltext_offset": 12663 + }, + { + "block_id": "p4:12", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Possible predictive factors affecting final clinical outcome were evaluated in a", + "found_in_fulltext": true, + "fulltext_offset": 13449 + }, + { + "block_id": "p5:0", + "page": 5, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:1", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "4589", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:2", + "page": 5, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 2 Preoperative and postoperative clinical outcome data of study groups", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:3", + "page": 5, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
Group I (poor outcome, n=24)Group II (good outc", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:4", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Data are reported as mean±standard deviation. Bolded p values indicate statistic", + "found_in_fulltext": true, + "fulltext_offset": 14378 + }, + { + "block_id": "p5:5", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A multivariate logistic regression analysis was then conducted following the fin", + "found_in_fulltext": true, + "fulltext_offset": 14726 + }, + { + "block_id": "p5:6", + "page": 5, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Discussion", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:7", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The most important finding of the present study is that female gender and degree", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:8", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The majority of data in the literature regarding the success of aRCR consists of", + "found_in_fulltext": true, + "fulltext_offset": 15047 + }, + { + "block_id": "p5:9", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "rotator cuff healing. However, the available data are con- flicting since some i", + "found_in_fulltext": true, + "fulltext_offset": 16417 + }, + { + "block_id": "p6:0", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "4590", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:1", + "page": 6, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:2", + "page": 6, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 3 Univariate analysis of baseline demographic and clinical data, intraoper", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:4", + "page": 6, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Data reported as mean ± standard deviation or n (%). Bolded p values indicate st", + "found_in_fulltext": true, + "fulltext_offset": 17574 + }, + { + "block_id": "p6:5", + "page": 6, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "BMI body mass index, CMS Constant–Murley score, VAS visual analogue scale, LHBT ", + "found_in_fulltext": true, + "fulltext_offset": 17677 + }, + { + "block_id": "p6:6", + "page": 6, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 4 Multivariate logistic regression analysis of predictive factors associat", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:8", + "page": 6, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "BMI body mass index, CI confidence interval, n.s. non-significant", + "found_in_fulltext": true, + "fulltext_offset": 17937 + }, + { + "block_id": "p6:9", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Consistent to these data, it was showed by the findings of the present study tha", + "found_in_fulltext": true, + "fulltext_offset": 18003 + }, + { + "block_id": "p6:10", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "dressing, and that women might have different subjective symptom perception comp", + "found_in_fulltext": true, + "fulltext_offset": 18403 + }, + { + "block_id": "p6:11", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Findings of the present study showed that second independent predictive factor a", + "found_in_fulltext": true, + "fulltext_offset": 18589 + }, + { + "block_id": "p7:0", + "page": 7, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:1", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "4591", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:2", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "showed that higher signal intensity of the repaired tendon on postoperative MRI ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:3", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Obesity has been recently reported as a risk factor for poor healing of RCTs $ [", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:4", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Determination of all contributors to clinical outcome is difficult since it is a", + "found_in_fulltext": true, + "fulltext_offset": 19728 + }, + { + "block_id": "p7:5", + "page": 7, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "This study has several limitations that need to be noted. Retrospective nature o", + "found_in_fulltext": true, + "fulltext_offset": 20473 + }, + { + "block_id": "p7:6", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Another limitation is that type of diabetes and level of gly- cemic control data", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:7", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This study also has some strength that needs to be mentioned. Compared to simila", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:8", + "page": 7, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Conclusion", + "found_in_fulltext": true, + "fulltext_offset": 1941 + }, + { + "block_id": "p7:9", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This study showed that despite successful healing of repaired tendon confirmed o", + "found_in_fulltext": true, + "fulltext_offset": 21857 + }, + { + "block_id": "p7:10", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Funding No funding was received for this study.", + "found_in_fulltext": true, + "fulltext_offset": 22324 + }, + { + "block_id": "p7:11", + "page": 7, + "role": "sub_subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Declarations", + "found_in_fulltext": true, + "fulltext_offset": 22377 + }, + { + "block_id": "p7:13", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Ethical approval IRB approval was obtained from institutional review board of Is", + "found_in_fulltext": true, + "fulltext_offset": 22390 + }, + { + "block_id": "p7:14", + "page": 7, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": true, + "fulltext_offset": 22570 + }, + { + "block_id": "p7:15", + "page": 7, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. 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"p12:9", + "p12:10", + "p13:0", + "p13:1", + "p13:2", + "p13:3", + "p13:4", + "p13:5", + "p13:6", + "p13:7", + "p13:8", + "p13:9", + "p13:10", + "p13:11", + "p13:12", + "p13:13", + "p13:14", + "p13:15", + "p13:16", + "p13:17", + "p13:18", + "p13:19", + "p13:20", + "p13:21", + "p13:22", + "p13:23", + "p13:24", + "p13:25", + "p13:26", + "p13:27", + "p13:28", + "p13:29", + "p13:30" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:21" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:22" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:23" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:24" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:25" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:26" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:27" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:28" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:29" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:30" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:1", + "p1:3", + "p1:4", + "p1:14", + "p2:5", + "p2:6", + "p2:7", + "p2:13", + "p3:15", + "p4:7", + "p4:8", + "p4:14", + "p5:8", + "p5:10", + "p5:11", + "p6:17", + "p7:17", + "p8:10", + "p9:1" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/3CIQWBGA/audit_report.md b/audit/3CIQWBGA/audit_report.md new file mode 100644 index 00000000..f5236fbb --- /dev/null +++ b/audit/3CIQWBGA/audit_report.md @@ -0,0 +1,37 @@ +# OCR Truth Audit Report - 3CIQWBGA + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 4, 6, 7, 8, 9, 10, 11, 12, 13] +- Reviewed blocks: 189 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/3CIQWBGA/audit_scope.json b/audit/3CIQWBGA/audit_scope.json new file mode 100644 index 00000000..a702c260 --- /dev/null +++ b/audit/3CIQWBGA/audit_scope.json @@ -0,0 +1,1618 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 4, + 6, + 7, + 8, + 9, + 10, + 11, + 12, + 13 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p4:7", + "p4:8", 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+page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,"Biomaterials Research +A SCIENCE PARTNER JOURNAL","[96.0, 60.0, 411.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,text,RESEARCH ARTICLE,"[95.0, 173.0, 307.0, 203.0]",authors,0.6,"[""page-1 initial-lastname author byline: RESEARCH ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,2,doc_title,Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects,"[95.0, 219.0, 742.0, 391.0]",paper_title,0.8,"[""page-1 zone title_zone: Enhanced Chondrogenic Differentiation of Electrically Primed""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,"Jongdarm Yi $ ^{1} $, Yujin Byun $ ^{2,3} $, Seong Soo Kang $ ^{2,3} $, Kyung Mi Shim $ ^{2,3} $, Kwangsik Jang $ ^{2,3*} $, and Jae Young Lee $ ^{1*} $","[94.0, 397.0, 769.0, 462.0]",authors,0.8,"[""page-1 zone author_zone: Jongdarm Yi $ ^{1} $, Yujin Byun $ ^{2,3} $, Seong Soo Kang ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text," $ ^{1} $School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. $ ^{2} $Department of Veterinary Surgery, College of Veterinary Me","[94.0, 475.0, 838.0, 584.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $School of Materials Science and Engineering, Gwangju""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,5,text,*Address correspondence to: jaeyounglee@gist.ac.kr (J.Y.L.); rhkdtlr0327@nate.com (K.J.),"[95.0, 603.0, 743.0, 629.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: *Address correspondence to: jaeyounglee@gist.ac.kr (J.Y.L.);""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,6,abstract,"Background: Mesenchymal stem cells (MSCs) offer a promising avenue for cartilage regeneration; however, their therapeutic efficacy requires substantial improvement. Cell priming using electrical stimu","[93.0, 650.0, 839.0, 1030.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,7,paragraph_title,Introduction,"[96.0, 1100.0, 230.0, 1126.0]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,8,text,"The articular cartilage is a specialized connective tissue covering the bone ends in synovial joints; it provides a smooth, lubricated surface for low-friction articulation and serves as a shock absor","[94.0, 1141.0, 593.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,vision_footnote,"Citation: Yi J, Byun Y, Kang SS, Shim KM, Jang K, Lee JY. Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects. Bioma","[869.0, 295.0, 1098.0, 470.0]",footnote,0.7,"[""vision_footnote label: Citation: Yi J, Byun Y, Kang SS, Shim KM, Jang K, Lee JY. En""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,10,text,"Submitted 4 June 2024 +Revised 12 October 2024 +Accepted 26 October 2024 +Published 18 December 2024","[869.0, 487.0, 1063.0, 568.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Submitted 4 June 2024\nRevised 12 October 2024\nAccepted 26 Oc""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,vision_footnote,"Copyright © 2024 Jongdarm Yi et al. +Exclusive licensee Korean Society for Biomaterials, Republic of Korea. +No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution ","[869.0, 583.0, 1111.0, 721.0]",frontmatter_noise,0.75,"[""page-1 DOI/date footnote: Copyright \u00a9 2024 Jongdarm Yi et al.\nExclusive licensee Korea""]",frontmatter_noise,0.75,frontmatter_main_zone,support_like,none,False,False +1,12,text,"(MSCs) have garnered substantial attention in cell therapy as an alternative because of their ease of isolation from diverse sources (e.g., adipose tissue, umbilical cord blood, bone marrow, and Whart","[618.0, 1096.0, 1119.0, 1275.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,13,text,"Many studies have used MSCs to treat articular cartilage defects. For instance, Park et al. [7] injected umbilical cord blood-derived MSCs with hyaluronic acid (HA)-based hydrogels into a knee full-th","[618.0, 1273.0, 1119.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95.0, 1531.0, 464.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,15,number,1,"[1103.0, 1532.0, 1116.0, 1552.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,0,header,Biomaterials Research,"[833.0, 62.0, 1102.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,text,"diseases, including articular cartilage defects. For example, human synovium-derived MSCs cultured under hypoxic conditions showed enhanced colony-forming characteristics, up-regulated messenger RNA (","[79.0, 126.0, 579.0, 391.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,2,text,"Inherent bioelectrical signals are involved in various physiological functions, including intercellular transmission and reception of electrical signals [11]. Hence, ES has been increasingly explored ","[79.0, 390.0, 579.0, 875.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"In this study, we aimed to enhance the chondrogenic differentiation of human MSCs by employing appropriate ES and facilitate the restoration of articular cartilage in vivo (Fig. 1). Specifically, we i","[80.0, 874.0, 579.0, 1076.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,image,,"[84.0, 1110.0, 574.0, 1400.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,5,figure_title,"Fig.1. Schematic illustration of electrically primed mesenchymal stem cells (epMSCs) and their chondrogenic potential and regeneration ability in articular cartilage. MSCs, mesenchymal stem cells; ES,","[81.0, 1412.0, 579.0, 1494.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.1. Schematic illustration of electrically primed mesench""]",figure_caption,0.85,body_zone,legend_like,none,False,False +2,6,text,and epMSCs to validate the ES-induced alterations in gene expression.,"[604.0, 126.0, 1103.0, 173.0]",unknown_structural,0.8,"[""page-1 zone title_zone: and epMSCs to validate the ES-induced alterations in gene ex""]",paper_title,0.8,body_zone,body_like,none,False,True +2,7,paragraph_title,Materials and Methods Materials,"[606.0, 201.0, 846.0, 267.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Materials and Methods Materials""]",authors,0.8,frontmatter_side_zone,heading_like,none,False,True +2,8,footer,,"[606.0, 243.0, 703.0, 267.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,9,text,"Human adipose-derived MSCs (hAD-MSCs) were purchased from PromoCell (Heidelberg, Germany). For ES, 316-L stainless-steel plates (3.8 cm × 2.8 cm × 0.7 cm) were obtained from BKSTEEL (Siheung, Republic","[602.0, 269.0, 1104.0, 933.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,Cell culture and investigation of ES on MSCs,"[605.0, 962.0, 1025.0, 986.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell culture and investigation of ES on MSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,11,text,"hAD-MSCs at passage 5 were used in all experiments. For maintenance, MSCs (1.0 × 10⁴ cells/cm²) were seeded on tissue culture plates and cultured in the growth medium (minimum essential medium-alpha s","[602.0, 987.0, 1104.0, 1229.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,text,"ES of the MSCs was performed using a 2-electrode system consisting of a platinum mesh (5 mm × 10 mm) and a cell-seeded stainless-steel plate as the counter and working electrodes, respectively. A copp","[604.0, 1230.0, 1104.0, 1496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82.0, 1531.0, 450.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,14,number,2,"[1086.0, 1532.0, 1103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,Biomaterials Research,"[847.0, 62.0, 1116.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +3,1,text,"were refreshed before the initial ES on day 1, and no further media were exchanged throughout the 3-d ES.","[94.0, 126.0, 592.0, 171.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,2,text,The cytocompatibility of MSCs subjected to different ES conditions was assessed using the LIVE/DEAD assay kit and metabolic activity measurements. Cell viability and metabolic activity were measured t,"[93.0, 171.0, 593.0, 657.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,Fluorescence-activated cell sorting analysis,"[94.0, 679.0, 511.0, 704.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Fluorescence-activated cell sorting analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,4,text,"One day after ES (on day 4 of the entire experimental period), MSCs were stained for stemness markers and analyzed by flow cytometry. Briefly, the cells were detached using 0.05% trypsin–EDTA, washed ","[93.0, 704.0, 593.0, 994.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Chondrogenic differentiation of MSCs,"[95.0, 1017.0, 455.0, 1042.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Chondrogenic differentiation of MSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,6,text,"The chondrogenic medium was prepared by adding 0.3 mM ascorbic acid, 0.35 mM L-proline, 0.1 μM dexamethasone, 1× ITS+3, and 10 ng/ml TGF-β3 in a high-glucose Dulbecco's modified Eagle's medium. One da","[92.0, 1042.0, 594.0, 1309.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,paragraph_title,Quantitative real-time polymerase chain reaction analysis,"[94.0, 1332.0, 477.0, 1383.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Quantitative real-time polymerase chain reaction analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,8,text,Quantitative real-time polymerase chain reaction (PCR) was performed after 14 d of culture in the chondrogenic medium. Total RNA was extracted from each group using the TRIzol reagent according to the,"[93.0, 1383.0, 593.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"ultraviolet–visible spectrophotometer (BioDrop Duo, BioDrop, +United Kingdom). Complementary DNA (cDNA) was synthe- +sized from the isolated mRNA using the High-Capacity cDNA +Reverse Transcription Kit (","[617.0, 126.0, 1118.0, 571.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,paragraph_title,Quantification of the sGAG content,"[619.0, 598.0, 956.0, 622.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Quantification of the sGAG content""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,11,text,"The sGAG content in the cells was quantified using the DMMB assay. After 2-week incubation in the chondrogenic differentiation medium, the cell pellets were collected and washed twice with DPBS. There","[618.0, 624.0, 1119.0, 998.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,text,"The DNA content of the cells was quantified using the Quant-iT PicoGreen double-stranded DNA assay kit according to the manufacturer's protocol. Briefly, a DNA standard solution (100 µg/ml) was dilute","[617.0, 998.0, 1119.0, 1263.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,paragraph_title,Pellet histology analysis,"[619.0, 1292.0, 854.0, 1316.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Pellet histology analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,14,text,"The cell pellets were fixed with 3.7% formaldehyde for 30 min and washed twice with DPBS. Then, the samples were incubated in sucrose solution (30% [w/v] in DPBS) for 24 h and embedded in the optimal ","[617.0, 1316.0, 1119.0, 1496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95.0, 1531.0, 464.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,16,number,3,"[1101.0, 1532.0, 1117.0, 1552.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Biomaterials Research,"[833.0, 61.0, 1102.0, 97.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +4,1,text,"incubated in 3% acetic acid for 3 min, and incubated in the Alcian blue solution (pH 2.5) at 25 °C for 30 min. The tissue sections were gently washed under running tap water for 10 min, followed by 3 ","[79.0, 126.0, 579.0, 590.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,2,text,"For immunocytochemistry, the sections were first washed in DDIW for 1 min and incubated in methanol for 20 min. The slides were then washed twice with DPBS for 5 min each. Following this, the slides w","[79.0, 587.0, 580.0, 990.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,Establishment of the OCD model and surgical procedures,"[80.0, 1023.0, 430.0, 1074.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Establishment of the OCD model and surgical procedures""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,4,text,"All animal experiments were approved by the Institutional Animal Care and Use Committee of Chonnam National University (CNU, Gwangju, Republic of Korea) (approval number: CNU IACUC-YB-2023-113), and t","[79.0, 1075.0, 579.0, 1252.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"One day after the final ES, cells were detached using 0.05% trypsin–EDTA and centrifuged at 300×g for 5 min. Cells (1 × 10⁷ cells/ml) were then resuspended in 2% HA solution (w/v in DPBS).","[80.0, 1250.0, 578.0, 1338.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"The rat OCD model was established as previously described with slight modifications [7]. Animals were pre-anesthetized using 5 mg per kilogram of animal weight each of ketoprofen (EAGLE VET, Seoul, Re","[80.0, 1338.0, 579.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,figure_title,Table. Detailed experimental groups for animal studies using an osteochondral defect model,"[625.0, 157.0, 1081.0, 205.0]",figure_caption_candidate,0.85,"[""figure_title label: Table. Detailed experimental groups for animal studies using""]",figure_caption,0.85,body_zone,legend_like,none,False,False +4,8,table,<,"[625.0, 215.0, 1080.0, 380.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,9,vision_footnote,"HA, hyaluronic acid; MSC, mesenchymal stem cells; epMSCs, electrically primed mesenchymal stem cells","[625.0, 394.0, 1082.0, 441.0]",footnote,0.7,"[""vision_footnote label: HA, hyaluronic acid; MSC, mesenchymal stem cells; epMSCs, el""]",footnote,0.7,body_zone,body_like,none,True,True +4,10,text,"injection for preventing infection and 1 mg of atropine (JEIL PHARM., Republic of Korea) per kg animal weight via subcutaneous injection for bradycardia prevention. Anesthesia was induced via intraper","[605.0, 525.0, 1104.0, 682.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,"The animal skin was disinfected with 10% povidone and alcohol, and a lateral parapatellar incision was made to expose the distal femoral trochlear groove surface. A full-thickness defect with a diamet","[604.0, 681.0, 1104.0, 1124.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,Macroscopic evaluation of cartilage repair,"[605.0, 1160.0, 1005.0, 1185.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Macroscopic evaluation of cartilage repair""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,13,text,"Distal femurs, including the defect, were harvested after euthanasia at 4 and 8 weeks after surgery and transplantation for macroscopic evaluation and imaging. Cartilage regeneration was assessed macr","[602.0, 1185.0, 1104.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[83.0, 1531.0, 450.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,15,number,4,"[1087.0, 1532.0, 1103.0, 1552.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,Biomaterials Research,"[848.0, 62.0, 1116.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +5,1,paragraph_title,Micro-computed tomography analysis of subchondral bone repair,"[95.0, 125.0, 480.0, 176.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Micro-computed tomography analysis of subchondral bone repai""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,2,text,The harvested distal femurs were fixed in neutral-buffered 10% formalin. Micro-computed tomography (micro-CT) analysis was performed to verify the extent of new subchondral bone formation in vivo. The,"[92.0, 176.0, 594.0, 1060.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,paragraph_title,Histological analysis,"[95.0, 1093.0, 295.0, 1118.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histological analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,4,text,"Histological analysis of cartilage regeneration at the defect sites was performed using H&E, Masson's trichrome, Alcian blue, and Safranin-O staining. Additionally, immunohistochemical (IHC) staining ","[93.0, 1118.0, 593.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,"contents in the cartilage, respectively. Additionally, 0.05% fast +green (Sigma-Aldrich) and Weigert hematoxylin solutions +(BioGnost, Zagreb, Croatia) were used to distinguish the sur- +rounding tissues","[618.0, 126.0, 1118.0, 568.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,"To quantitatively evaluate the degree of histological cartilage repair, the sections were analyzed using the O'Driscoll histological cartilage repair scale (Table S2) based on Safranin-O-stained image","[618.0, 568.0, 1119.0, 944.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,paragraph_title,Total RNA sequencing and data analysis,"[619.0, 960.0, 998.0, 984.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Total RNA sequencing and data analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,8,text,"From each sample, $ 1 \times 10^6 $ MSCs and epMSCs were collected for total RNA sequencing. Quantitative RNA sequencing (Quant-Seq) was performed in duplicate (Ebiogen, Seoul, Republic of Korea). Th","[617.0, 984.0, 1119.0, 1296.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,9,paragraph_title,Statistical analyses,"[619.0, 1314.0, 812.0, 1339.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical analyses""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,10,text,All tests were performed in quadruplicate $ (n = 4) $ unless otherwise noted. Results are reported as mean ± standard deviation unless otherwise noted. Differences between groups were analyzed using ,"[617.0, 1338.0, 1118.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95.0, 1531.0, 464.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,12,number,5,"[1101.0, 1531.0, 1117.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Biomaterials Research,"[833.0, 62.0, 1103.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +6,1,paragraph_title,Results Cytocompatibility of ES conditions,"[80.0, 125.0, 413.0, 194.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Results Cytocompatibility of ES conditions""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +6,2,footer,,"[80.0, 169.0, 413.0, 194.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +6,3,text,"Appropriate ES is crucial for effective modulation of MSCs' characteristics without damaging their viability [20]. To this end, we examined the ES parameters of various previously reported ES systems ","[79.0, 193.0, 580.0, 594.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,text,"metabolic activity compared with that of both the unstimu- +lated (3.27 ± 0.04) and 0.3 V and 1 Hz (3.26 ± 0.08) groups +(Fig. 2 D). No significant differences in cell viability or meta- +bolic activity ","[604.0, 126.0, 1104.0, 259.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,text,"Moreover, ES-induced possible changes in stemness were investigated by analyzing the expression of stemness-related surface markers (Fig. 2E and Fig. S2). The stemness of MSCs is generally characteriz","[603.0, 259.0, 1105.0, 592.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,figure_title,A,"[89.0, 637.0, 111.0, 660.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,7,figure_title,B,"[474.0, 637.0, 492.0, 658.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,8,chart,,"[81.0, 746.0, 483.0, 876.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,image,,"[506.0, 655.0, 1098.0, 1004.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,10,figure_title,C,"[101.0, 1031.0, 122.0, 1053.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,11,figure_title,D,"[420.0, 1031.0, 441.0, 1054.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,12,chart,,"[112.0, 1075.0, 365.0, 1420.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,13,figure_title,E,"[736.0, 1031.0, 755.0, 1053.0]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,14,chart,,"[430.0, 1074.0, 676.0, 1418.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,15,chart,,"[745.0, 1075.0, 1010.0, 1364.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,16,figure_title,Fig. 2. Viability and stemness maintenance of human adipose-derived MSCs electrically stimulated under diverse parameters. (A) Schematic experimental timeline. (B) Representative fluorescent images of,"[80.0, 1433.0, 1103.0, 1496.0]",figure_caption,0.92,"[""figure_title label: Fig. 2. Viability and stemness maintenance of human adipose-""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,17,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82.0, 1531.0, 451.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,18,number,6,"[1087.0, 1531.0, 1103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Biomaterials Research,"[847.0, 61.0, 1117.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +7,1,text,"MSCs, such as their immunomodulatory capacity and differentiation potential [24].","[94.0, 125.0, 591.0, 174.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,2,paragraph_title,In vitro chondrogenic differentiation of epMSCs,"[94.0, 190.0, 545.0, 215.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: In vitro chondrogenic differentiation of epMSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,3,text,The chondrogenic differentiation capability of epMSCs was assessed by analyzing the mRNA expression and extracellular matrix (ECM) production after 2 weeks of culture in chondrogenic media (Fig. 3A). ,"[93.0, 216.0, 593.0, 396.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"cartilage and involved in the early stages of chondrogenesis; it +serves as one of the earliest markers indicating the commitment +of cells to a chondrocyte lineage and the production of ECM +necessary f","[617.0, 126.0, 1120.0, 394.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,figure_title,A,"[142.0, 420.0, 164.0, 442.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,6,image,,"[152.0, 440.0, 783.0, 573.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,7,figure_title,B,"[143.0, 608.0, 163.0, 630.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,8,chart,,"[177.0, 623.0, 612.0, 940.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,9,figure_title,C,"[699.0, 609.0, 718.0, 630.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,10,chart,,"[701.0, 619.0, 992.0, 1005.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,11,figure_title,D,"[143.0, 1020.0, 162.0, 1040.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,12,image,,"[143.0, 1024.0, 609.0, 1384.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,F,"[855.0, 1019.0, 873.0, 1042.0]",figure_inner_text,0.9,"[""panel label / figure inner text: F""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,14,chart,,"[620.0, 1047.0, 845.0, 1393.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,15,chart,,"[856.0, 1057.0, 1072.0, 1393.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,16,figure_title,"Fig. 3. In vitro chondrogenic differentiation of epMSCs. (A) Schematic experimental timeline. (B) Relative expression of chondrogenic genes (COL2A1, SOX9, and ACAN) (n = 5). (C) Amount of sulfated gly","[95.0, 1411.0, 1120.0, 1496.0]",figure_caption,0.92,"[""figure_title label: Fig. 3. In vitro chondrogenic differentiation of epMSCs. (A)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,17,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95.0, 1531.0, 464.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,18,number,7,"[1101.0, 1531.0, 1117.0, 1552.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Biomaterials Research,"[833.0, 61.0, 1103.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +8,1,text,"stages of chondrogenesis, plays a critical role in mediating chondrocyte–ECM interactions [27]. ACAN expression in the epMSC (0.3 V and 1 Hz) group was 8.5- and 3.9-fold higher than those in the unsti","[79.0, 126.0, 579.0, 281.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,2,text,"The sGAG content, a major component of the cartilage ECM, was significantly increased by ES at 0.3 V and 1 Hz from 7.1 ± 0.3 to 8.8 ± 0.9, whereas the production of sGAG in epMSCs (0.3 V and 100 Hz; 7","[79.0, 281.0, 580.0, 768.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,"Immunofluorescence staining for COL1 and COL2 further +verified the superior chondrogenic differentiation of the epMSCs +compared to that of MSCs (Fig. S3). epMSCs exhibited higher +expression of COL2 (a","[603.0, 125.0, 1104.0, 394.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,Macroscopic evaluations of cartilage regeneration,"[605.0, 410.0, 1080.0, 435.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Macroscopic evaluations of cartilage regeneration""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +8,5,text,"The in vivo therapeutic efficacy of epMSCs for cartilage regeneration was investigated in a rodent OCD model (Fig. S4). The experimental groups included untreated controls, HA-only, HA + MSCs, and HA ","[602.0, 435.0, 1104.0, 769.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,figure_title,A,"[83.0, 796.0, 105.0, 819.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,7,image,,"[85.0, 811.0, 1099.0, 1407.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,8,chart,,"[740.0, 1071.0, 1100.0, 1402.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,"Fig. 4. Macroscopic evaluation of cartilage repair in the rat model at 4 and 8 weeks after the surgery and treatments (nontreated control [Control], hyaluronic acid (HA)-only, HA + MSCs, and HA + epMS","[78.0, 1412.0, 1104.0, 1495.0]",figure_caption,0.92,"[""figure_title label: Fig. 4. Macroscopic evaluation of cartilage repair in the ra""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,10,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82.0, 1531.0, 451.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,11,number,8,"[1087.0, 1531.0, 1103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,Biomaterials Research,"[847.0, 61.0, 1117.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +9,1,text,"of the control, HA-only, HA + MSCs, and HA + epMSCs groups at week 4 were $ 4.6 \pm 2.2 $, $ 5.7 \pm 1.7 $, $ 6.9 \pm 2.0 $, and $ 8.7 \pm 1.6 $, respectively. Notably, the HA + epMSCs group exhib","[93.0, 126.0, 593.0, 350.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,2,paragraph_title,Micro-CT evaluation of the newly formed subchondral bone,"[94.0, 363.0, 479.0, 414.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Micro-CT evaluation of the newly formed subchondral bone""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,3,text,"Because the articular cartilage of a rat is typically thin and micro-CT imaging has limited resolution, it was challenging to accurately compare the degrees of cartilage regeneration among all groups ","[93.0, 415.0, 594.0, 772.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,paragraph_title,Histological evaluations in the rat OCD model,"[94.0, 805.0, 525.0, 831.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histological evaluations in the rat OCD model""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,5,text,"H&E staining (Fig. 6A) showed that the articular cartilage of the HA + epMSCs group presented a smooth and regular surface morphology compared with those of the other groups. Similarly, Masson's trich","[94.0, 830.0, 594.0, 945.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,text,"distribution of collagen fibers in the regenerated cartilage (Fig. +6 B). Although the control group displayed faint Alcian blue +and Safranin-O staining, the HA + epMSCs group showed +distinct blue and ","[618.0, 125.0, 1119.0, 589.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,text,Quantitative analysis using the modified O'Driscoll histological cartilage repair scale further indicated that the HA + epMSCs group exhibited a higher proportion of hyaline cartilage and a higher sta,"[617.0, 590.0, 1119.0, 943.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,figure_title,A,"[96.0, 972.0, 119.0, 994.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,figure_title,B,"[676.0, 971.0, 695.0, 993.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,10,image,,"[98.0, 982.0, 1115.0, 1413.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,11,figure_title,Fig. 5. Micro-computed tomography (micro-CT) of the subchondral bone formation in the defect area (n = 5 for each group). (A) Three-dimensional (3D) reconstruction (yellow color indicates newly formed,"[95.0, 1432.0, 1117.0, 1495.0]",figure_caption,0.92,"[""figure_title label: Fig. 5. Micro-computed tomography (micro-CT) of the subchond""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,12,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95.0, 1531.0, 465.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,13,number,9,"[1100.0, 1531.0, 1117.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,Biomaterials Research,"[833.0, 62.0, 1102.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +10,1,paragraph_title,A H&E,"[82.0, 129.0, 186.0, 154.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: A H&E""]",subsection_heading,0.6,body_zone,unknown_like,short_fragment,True,True +10,2,image,,"[88.0, 189.0, 578.0, 390.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,3,figure_title,B Masson's trichrome,"[600.0, 127.0, 840.0, 154.0]",figure_caption_candidate,0.85,"[""figure_title label: B Masson's trichrome""]",figure_caption,0.85,body_zone,unknown_like,none,False,False +10,4,image,,"[609.0, 190.0, 1098.0, 392.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,5,figure_title,C Alcian blue,"[82.0, 416.0, 245.0, 441.0]",figure_caption_candidate,0.85,"[""figure_title label: C Alcian blue""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +10,6,image,,"[83.0, 471.0, 573.0, 671.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,7,figure_title,D Safranin-O,"[601.0, 416.0, 762.0, 441.0]",figure_caption_candidate,0.85,"[""figure_title label: D Safranin-O""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +10,8,image,,"[608.0, 465.0, 1099.0, 670.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,9,figure_title,E Type-II collagen (COL2),"[81.0, 704.0, 364.0, 733.0]",figure_caption,0.85,"[""figure_title label: E Type-II collagen (COL2)""]",figure_caption,0.85,body_zone,unknown_like,none,True,True +10,10,image,,"[84.0, 711.0, 574.0, 994.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,11,figure_title,F,"[602.0, 704.0, 620.0, 724.0]",figure_inner_text,0.9,"[""panel label / figure inner text: F""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,12,chart,,"[675.0, 704.0, 1017.0, 1008.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,13,figure_title,"Fig. 6. Histological and immunohistochemical (IHC) analyses of cartilage repair in the rat model at weeks 4 and 8 after transplantation. (A) Hematoxylin and eosin (H&E), (B) Masson's trichrome, (C) Al","[79.0, 1017.0, 1103.0, 1100.0]",figure_caption,0.92,"[""figure_title label: Fig. 6. Histological and immunohistochemical (IHC) analyses ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +10,14,paragraph_title,Total RNA sequencing analysis of epMSCs,"[81.0, 1138.0, 478.0, 1163.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Total RNA sequencing analysis of epMSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +10,15,text,"Total RNA sequencing was performed to explore the mechanisms underlying epMSC-mediated enhancement of chondrogenic differentiation in vitro and cartilage regeneration in vivo. In total, 128 DEGs with ","[79.0, 1162.0, 580.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,16,text,"signaling pathway, and cartilage development) were further +extracted (Fig. 7 E).","[604.0, 1139.0, 1103.0, 1184.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,17,text,"The ECM plays a key role in forming a complex network of macromolecules, providing structural support, transducing signals for cellular communication, and regulating cellular behavior through interact","[602.0, 1184.0, 1105.0, 1496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,18,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82.0, 1531.0, 451.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,19,number,10,"[1077.0, 1531.0, 1103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,Biomaterials Research,"[847.0, 61.0, 1116.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,1,figure_title,A,"[96.0, 126.0, 117.0, 149.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,2,chart,,"[99.0, 144.0, 416.0, 457.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,3,figure_title,B,"[430.0, 126.0, 448.0, 147.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,4,chart,,"[428.0, 131.0, 764.0, 451.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,5,figure_title,C,"[827.0, 126.0, 847.0, 148.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,6,figure_title,D,"[97.0, 496.0, 117.0, 519.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,7,chart,,"[156.0, 494.0, 671.0, 817.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,8,image,,"[822.0, 128.0, 1112.0, 791.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,9,figure_title,E,"[96.0, 845.0, 116.0, 868.0]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,10,chart,,"[198.0, 834.0, 951.0, 1202.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,11,figure_title,Fig. 7. Total RNA sequencing of MSCs and epMSCs (n = 3 for each group). (A) Comparison of gene expression as a scatter plot between MSCs and epMSCs. (B) Volcano plot of −log₁₀(P value) versus log₂(fol,"[95.0, 1219.0, 1117.0, 1403.0]",figure_caption,0.92,"[""figure_title label: Fig. 7. Total RNA sequencing of MSCs and epMSCs (n = 3 for e""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,True,True +11,12,text,"phospholipid scramblase 1 [PLSCR1], fibulin-1 [FBLN1], and podocan-like protein 1 [PODNL1]) were down-regulated, whereas 4 genes (wingless-related integration site [WNT5B], serpin family E member 1 [S","[95.0, 1425.0, 594.0, 1496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +11,13,text,"E member 1 [SERPINE1], type XIII collagen alpha 1 chain +[COL13A1], and semaphorin 7A [SEMA7A]) were up-regulated. +In particular, FBLN1, COL13A1, PODNL1, INHBE, and SOD3","[618.0, 1425.0, 1118.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,14,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[96.0, 1531.0, 464.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,15,number,11,"[1096.0, 1531.0, 1117.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +12,0,header,Biomaterials Research,"[833.0, 62.0, 1102.0, 96.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +12,1,text,"contribute to ECM organization, whereas ADAMTS5, CLU, SERPINE1, and WNT5B are involved in ECM remodeling [30–37]. CCN5, PLSCR1, SEMA7A, and WNT2B mediate cell–ECM interactions and signal transduction ","[79.0, 127.0, 580.0, 768.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,2,paragraph_title,Discussion,"[81.0, 793.0, 200.0, 818.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True +12,3,text,"Owing to their unique ability to self-renew, differentiate, and modulate the immune response, MSCs have garnered considerable attention for the cell-based therapy of various tissue diseases, including","[79.0, 830.0, 580.0, 1272.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,4,text,"Our findings indicated that priming MSCs with ES under optimal conditions (0.3 V and 1 Hz) significantly improved the expression of chondrogenic genes and cartilage-specific proteins, including COL2, ","[79.0, 1271.0, 579.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,5,text,"in gene expression profiles after ES, particularly in pathways +related to ECM organization, Wnt signaling, and cartilage +development. +ES l di V i d i bl l","[604.0, 126.0, 1103.0, 194.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,6,text,"ES voltages exceeding 0.5 V can trigger undesirable electrochemical reactions within the culture media, leading to alterations in protein structures and disruptions to the cellular microenvironment [2","[603.0, 194.0, 1105.0, 656.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,7,text,"For OCD repair, numerous studies have used MSCs with hydrogels to enhance their applicability and efficacy [53]. In this study, we evaluated the effects of epMSCs using HA, a major ECM component of th","[603.0, 655.0, 1104.0, 1029.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,8,text,"Nanosecond pulsed electric field can affect intracellular signaling pathways by activating c-Jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase, and Wnt signaling [54]. Recently, ","[603.0, 1030.0, 1105.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,9,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82.0, 1531.0, 451.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +12,10,number,12,"[1079.0, 1531.0, 1103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +13,0,header,Biomaterials Research,"[848.0, 62.0, 1116.0, 95.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +13,1,text,"growth and repair. DEGs involved in the immune response, cell differentiation, and other related processes suggest that ES can induce the creation of a favorable microenvironment for tissue regenerati","[94.0, 127.0, 593.0, 435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,2,text,"With an aim to improve therapeutic effectiveness of MSCs, we explored preconditioning MSCs with the appropriate ES in vitro to increase their chondrogenic differentiation. Transplantation of epMSCs wi","[94.0, 435.0, 593.0, 701.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,paragraph_title,Acknowledgments,"[96.0, 733.0, 288.0, 760.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,4,text,Funding: This research was supported by the Challengeable Future Defense Technology Research and Development Program through the Agency for Defense Development (ADD) funded by the Defense Acquisition ,"[95.0, 774.0, 591.0, 885.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,text,"Author contributions: J.Y.: methodology, investigation, formal analysis, data curation, writing—original draft and review and editing, software, validation, and visualization. Y.B.: investigation and ","[95.0, 886.0, 592.0, 1061.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,support_like,none,True,True +13,6,text,Competing interests: The authors declare that they have no competing interests.,"[96.0, 1061.0, 591.0, 1107.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,paragraph_title,Data Availability,"[96.0, 1146.0, 267.0, 1174.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data Availability""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,8,text,The data that support the findings of this study are available from the corresponding authors upon reasonable request.,"[95.0, 1190.0, 591.0, 1238.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,9,paragraph_title,Supplementary Materials,"[96.0, 1267.0, 358.0, 1294.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supplementary Materials""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +13,10,text,Figs. S1 to S7 Tables S1 and S2,"[97.0, 1305.0, 236.0, 1350.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,11,paragraph_title,References,"[96.0, 1378.0, 216.0, 1405.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +13,12,reference_content,"1. Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of articular cartilage: Structure, composition, and function. Sports Health. 2009;1(6):461–468.","[107.0, 1426.0, 591.0, 1490.0]",reference_item,0.85,"[""reference content label: 1. Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of art""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,13,reference_content,"2. Boeuf S, Richter W. Chondrogenesis of mesenchymal stem cells: Role of tissue source and inducing factors. 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ControlNo materialNo cells
HA-only2% HANo cells
,"[105.0, 208.0, 432.0, 423.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,4,vision_footnote,Note—Rotator cuff integrity was classified according to the system published by Sugaya et al. [18].,"[113.0, 427.0, 434.0, 465.0]",footnote,0.7,"[""vision_footnote label: Note\u2014Rotator cuff integrity was classified according to the ""]",footnote,0.7,body_zone,body_like,none,True,True +4,5,text,"tendon on 83 postoperative MR images was type I in two (2.4%) patients, type II in 19 (22.9%) patients, type III in 14 (16.9%) patients, type IV in 10 (12.0%) patients, and type V in 38 (45.8%) patien","[101.0, 493.0, 437.0, 737.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Comparison of Demographics and Preoperative Radiologic Findings Between the Intact and Retear Groups,"[103.0, 757.0, 426.0, 824.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Comparison of Demographics and Preoperative Radiologic Findi""]",subsection_heading,0.6,body_zone,body_like,none,True,True +4,7,footer,,"[103.0, 775.0, 426.0, 824.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,8,text,The mean age at the time of surgery was $ 59.6 \pm 7.1 $ years in the intact group and $ 62.4 \pm 5.9 $ years in the retear group. There was no statistically significant difference between the two g,"[103.0, 825.0, 436.0, 936.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,image,,"[103.0, 959.0, 436.0, 1294.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,10,figure_title,Fig. 5—60-year-old woman with full-thickness tear of supraspinatus tendon. Acromiohumeral interval (bidirectional arrow) was measured as minimum length between acromion and humeral head (parallel line,"[102.0, 1313.0, 430.0, 1418.0]",figure_caption,0.92,"[""figure_title label: Fig. 5\u201460-year-old woman with full-thickness tear of suprasp""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,11,text,"There were 13 men and 22 women in the intact group, and there were 15 men and 33 women in the retear group. There was no statistically significant difference in the sex ratio of the two groups $ (p =","[450.0, 141.0, 783.0, 251.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,"The preoperative mean extent of tendon retraction was $ 20.4 \pm 9.7 $ mm (range, 5.8–48.0 mm) in the retear group and $ 11.7 \pm 8.1 $ mm (range, 1.7–31.0) in the intact group. The preoperative mea","[450.0, 252.0, 784.0, 427.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,text,"There was a significant difference in the degree of fat infiltration of the supraspinatus muscle between the intact and retear groups (p = 0.034). Also, there was a significant difference in the degre","[451.0, 427.0, 785.0, 560.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,text,"retear groups (p = 0.023). The preoperative +mean AP dimension of tear was 16.1 ± 8.6 mm +(range, 2.6–42.9 mm) in the retear group and +11.4 ± 9.9 mm (range, 2.2–44.0) in the intact +group. The mean AP di","[798.0, 142.0, 1134.0, 404.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,15,text,"There was a significant difference in the degree of fat infiltration of the supraspinatus muscle between the intact and retear groups $ (p=0.034) $. Also, there was a significant difference in the de","[798.0, 406.0, 1133.0, 561.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,16,figure_title,TABLE 2: Comparison of Demographics and Preoperative Radiologic Findings Between the Intact and Retear Groups,"[451.0, 588.0, 1129.0, 630.0]",table_caption,0.9,"[""table prefix matched: TABLE 2: Comparison of Demographics and Preoperative Radiolo""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,17,table,"
GroupImplanted materialImplanted cells
Sugaya ClassificationNo. (%) of Patients ( $ n = 83 $)
I2 (2.4)
II19 (22.9)
III14 (16.9)
VariableIntact Group (n = 35)Retear Group (n = 48)p $ ^{a} $
Age (y), mean $ \pm $ SD (range)59.6 $ \pm $ 7.1 (44-73)62.4","[456.0, 636.0, 1123.0, 1355.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,18,vision_footnote,"Note—Except where noted otherwise, data are number of patients.","[461.0, 1361.0, 872.0, 1380.0]",footnote,0.7,"[""vision_footnote label: Note\u2014Except where noted otherwise, data are number of patien""]",footnote,0.7,body_zone,body_like,none,True,True +4,19,vision_footnote,Values shown in bold type are statistically significant.,"[460.0, 1379.0, 795.0, 1397.0]",footnote,0.7,"[""vision_footnote label: Values shown in bold type are statistically significant.""]",footnote,0.7,body_zone,body_like,none,True,True +4,20,vision_footnote, $ ^{b} $Goutallier classification system was used [7].,"[461.0, 1396.0, 744.0, 1416.0]",footnote,0.7,"[""vision_footnote label: $ ^{b} $Goutallier classification system was used [7].""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +4,21,footer,"AJR:210, January 2018","[105.0, 1479.0, 261.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,22,number,137,"[1104.0, 1480.0, 1131.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[0.0, 252.0, 22.0, 1308.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +5,1,header,Shin et al.,"[542.0, 92.0, 634.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,text,"The mean AHI at preoperative MRI was $ 6.8 \pm 2.1 $ mm (range, 1.6–10.4 mm) in the retear group and $ 8.7 \pm 1.2 $ mm (range, 5.0–10.47 mm) in the intact group. The mean AHI at preoperative MRI wa","[72.0, 141.0, 406.0, 297.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,text,"There were no statistically significant differences in the type of tear and signal intensity of tear edge between the intact and retear groups (p = 0.180 and 0.185, respectively). Table 2 shows specif","[72.0, 296.0, 406.0, 429.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,paragraph_title,Univariable Analysis of Radiologic Finding Associated With Retear of Repaired Rotator Cuff,"[72.0, 450.0, 407.0, 493.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Univariable Analysis of Radiologic Finding Associated With R""]",subsection_heading,0.6,body_zone,body_like,none,True,True +5,5,footer,,"[72.0, 471.0, 407.0, 493.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +5,6,text,"On univariable analysis, there were no statistically significant differences between the retear and intact groups in terms of patient age or sex, type of tear (full-thickness partial-width vs full-thi","[72.0, 495.0, 406.0, 779.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,The retear rate of the supraspinatus tendon was significantly higher in patients with higher fat infiltration of the supraspinatus $ (p = 0.049) $ and infraspinatus muscles $ (p = 0.045) $. Supraspi,"[72.0, 780.0, 408.0, 1001.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,figure_title,TABLE 3: Univariable Analysis of Radiologic Finding Associated With Retear of Repaired Rotator Cuff,"[420.0, 138.0, 1090.0, 183.0]",table_caption,0.9,"[""table prefix matched: TABLE 3: Univariable Analysis of Radiologic Finding Associat""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,9,table,
VariableOdds Ratio (95% CI)p $ ^{a} $
Sex1.069 (0.996-1.147)0.064
Age1.300 (0.519-3.255)0.575
Variable $ ^{a} $Odds Ratio (95% CI)p $ ^{b} $
Tendon retraction1.092 (1.006-1.185)0.036
Anteroposterior dimension<,"[453.0, 988.0, 1129.0, 1353.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,17,vision_footnote, $ ^{a} $The variables were adjusted according to patient age and sex.,"[459.0, 1357.0, 841.0, 1377.0]",footnote,0.7,"[""vision_footnote label: $ ^{a} $The variables were adjusted according to patient age""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +6,18,vision_footnote,Values shown in bold type are statistically significant.,"[459.0, 1376.0, 795.0, 1393.0]",footnote,0.7,"[""vision_footnote label: Values shown in bold type are statistically significant.""]",footnote,0.7,body_zone,body_like,none,True,True +6,19,vision_footnote, $ ^{c} $Goutallier classification was used [7].,"[460.0, 1393.0, 698.0, 1412.0]",footnote,0.7,"[""vision_footnote label: $ ^{c} $Goutallier classification was used [7].""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +6,20,footer,"AJR:210, January 2018","[105.0, 1479.0, 261.0, 1499.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,21,number,139,"[1104.0, 1480.0, 1132.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[0.0, 258.0, 22.0, 1309.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +7,1,header,Shin et al.,"[542.0, 92.0, 633.0, 115.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,tears. Such cases suggest that there would be important factors other than AP dimension of tear that affect tendon integrity after repair.,"[72.0, 142.0, 405.0, 207.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"In this study, preoperative AHI was proven to be an independent predictive factor related to retear. To our knowledge, there has been no multivariable analysis that used MRI to study the relationship ","[73.0, 209.0, 407.0, 1130.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,4,text,"In the current study, we could not conclude that the degree of fat infiltration in the supraspinatus and infraspinatus muscles is an independent prognostic factor that affects retear. A greater degree","[72.0, 1132.0, 407.0, 1420.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,5,text,"fraspinatus muscles is related to retear. How- +ever, it was not a significant prognostic fac- +tor of retear in multivariable analysis. There +may be two possible reasons for such a re- +sult. First, the","[420.0, 143.0, 754.0, 646.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"In this study, the signal intensity of tear edge at preoperative MRI was not significantly related to retear. The signal intensity on T2-weighted images increases because of the edema and hemorrhage t","[420.0, 648.0, 755.0, 1065.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,7,text,"There are some limitations to this study. First, it is a retrospective study. Second, the mean follow-up period after surgery was relatively short (312.4 days; range, 251–435 days). Further long-term ","[419.0, 1066.0, 755.0, 1419.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,8,text,"functional outcomes [16, 32, 33]. Further- +more, potential bias may arise in the evalu- +ation of postoperative functional outcome, +which can cause an overestimation in the +degree of improvement. Becau","[768.0, 143.0, 1104.0, 669.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"In conclusion, the retear rate after surgical repair of supraspinatus full-thickness tendon tear is 57.8%. Preoperative degree of tendon retraction and AHI are independent prognostic factors of retear","[768.0, 670.0, 1103.0, 826.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,paragraph_title,References,"[771.0, 846.0, 873.0, 866.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +7,11,reference_content,"1. Lenza M, Buchbinder R, Takwoingi Y, Johnston RV, Hanchard NCA, Faloppa F. Magnetic resonance imaging, magnetic resonance arthrography and ultrasonography for assessing rotator cuff tears in people ","[778.0, 870.0, 1101.0, 1019.0]",reference_item,0.85,"[""reference content label: 1. Lenza M, Buchbinder R, Takwoingi Y, Johnston RV, Hanchard""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,12,reference_content,"2. Bellumore Y, Mansat M, Assoun J. Results of the surgical repair of the rotator cuff: radio-clinical correlation [in French]. Rev Chir Orthop Reparatrice Appar Mot 1994; 80:582–594","[780.0, 1025.0, 1101.0, 1109.0]",reference_item,0.85,"[""reference content label: 2. Bellumore Y, Mansat M, Assoun J. Results of the surgical ""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True +7,13,reference_content,"3. Galatz LM, Ball CM, Teefey SA, Middleton WD, Yamaguchi K. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am 2004; 8","[780.0, 1113.0, 1101.0, 1218.0]",reference_item,0.85,"[""reference content label: 3. Galatz LM, Ball CM, Teefey SA, Middleton WD, Yamaguchi K.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,14,reference_content,"4. McElvany MD, McGoldrick E, Gee AO, Neradilek MB, Matsen FA 3rd. Rotator cuff repair: published evidence on factors associated with repair integrity and clinical outcome. Am J Sports Med 2015; 43:49","[780.0, 1223.0, 1100.0, 1328.0]",reference_item,0.85,"[""reference content label: 4. McElvany MD, McGoldrick E, Gee AO, Neradilek MB, Matsen F""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,15,reference_content,"5. Fuchs B, Gilbert MK, Hodler J, Gerber C. Clinical and structural results of open repair of an isolated one-tendon tear of the rotator cuff. 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For personal use only; all rights reserved,"[0.0, 257.0, 22.0, 1308.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +8,1,header,Retear of Repaired Rotator Cuff Tear Seen at MRI,"[400.0, 93.0, 836.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +8,2,reference_content,"6. Gladstone JN, Bishop JY, Lo IK, Flatow EL. Fatty infiltration and atrophy of the rotator cuff do not improve after rotator cuff repair and correlate with poor functional outcome. Am J Sports Med 20","[114.0, 142.0, 435.0, 246.0]",reference_item,0.85,"[""reference content label: 6. Gladstone JN, Bishop JY, Lo IK, Flatow EL. Fatty infiltra""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,3,reference_content,"7. Goutallier D, Postel JM, Bernageau J, Lavau L, Voisin MC. Fatty muscle degeneration in cuff ruptures: pre- and postoperative evaluation by CT scan. 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Long-term functional outcomes after repair of rotator cuff tears correlated with atrophy of the supraspinatus muscles on magnetic resonance images.","[115.0, 428.0, 435.0, 533.0]",reference_item,0.85,"[""reference content label: 9. Shen PH, Lien SB, Shen HC, Lee CH, Wu SS, Lin LC. Long-te""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,6,reference_content,"10. Schaefer O, Winterer J, Lohrmann C, Laubenberger J, Reichelt A, Langer M. Magnetic resonance imaging for supraspinatus muscle atrophy after cuff repair. Clin Orthop Relat Res 2002; 403:93–99","[111.0, 538.0, 434.0, 622.0]",reference_item,0.85,"[""reference content label: 10. Schaefer O, Winterer J, Lohrmann C, Laubenberger J, Reic""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,7,reference_content,"11. Burkhart SS, Barth JR, Richards DP, Zlatkin MB, Larsen M. Arthroscopic repair of massive rotator cuff tears with stage 3 and 4 fatty degeneration. Arthroscopy 2007; 23:347–354","[111.0, 626.0, 434.0, 710.0]",reference_item,0.85,"[""reference content label: 11. Burkhart SS, Barth JR, Richards DP, Zlatkin MB, Larsen M""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,8,reference_content,"12. Mellado JM, Calmet J, Olona M, et al. Surgically repaired massive rotator cuff tears: MRI of tendon integrity, muscle fatty degeneration, and muscle atrophy correlated with intraoperative and clin","[110.0, 715.0, 434.0, 820.0]",reference_item,0.85,"[""reference content label: 12. Mellado JM, Calmet J, Olona M, et al. Surgically repaire""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,9,reference_content,"13. Gerber C, Schneeberger AG, Hoppeler H, Meyer DC. Correlation of atrophy and fatty infiltration on strength and integrity of rotator cuff repairs: a study in thirteen patients. J Shoulder Elbow Sur","[110.0, 826.0, 435.0, 929.0]",reference_item,0.85,"[""reference content label: 13. Gerber C, Schneeberger AG, Hoppeler H, Meyer DC. Correla""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,10,reference_content,"14. Jost B, Pfirrmann CW, Gerber C, Switzerland Z. Clinical outcome after structural failure of rotator cuff repairs. J Bone Joint Surg Am 2000; 82:304–314","[111.0, 935.0, 434.0, 997.0]",reference_item,0.85,"[""reference content label: 14. Jost B, Pfirrmann CW, Gerber C, Switzerland Z. Clinical ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,11,reference_content,"15. Gusmer PB, Potter HG, Donovan WD, O'Brien SJ.","[109.0, 1000.0, 433.0, 1018.0]",reference_item,0.85,"[""reference content label: 15. Gusmer PB, Potter HG, Donovan WD, O'Brien SJ.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,12,reference_content,MR imaging of the shoulder after rotator cuff repair. AJR 1997; 168:559–563,"[476.0, 142.0, 782.0, 181.0]",reference_item,0.85,"[""reference content label: MR imaging of the shoulder after rotator cuff repair. AJR 19""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +8,13,reference_content,"16. Kim JR, Cho YS, Ryu KJ, Kim JH. Clinical and radiographic outcomes after arthroscopic repair of massive rotator cuff tears using a suture bridge technique: assessment of repair integrity on magnet","[458.0, 186.0, 783.0, 312.0]",reference_item,0.85,"[""reference content label: 16. Kim JR, Cho YS, Ryu KJ, Kim JH. Clinical and radiographi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,14,reference_content,"17. Davidson JF, Burkhart SS, Richards DP, Campbell SE. Use of preoperative magnetic resonance imaging to predict rotator cuff tear pattern and method of repair. Arthroscopy 2005; 21:1428","[460.0, 319.0, 782.0, 402.0]",reference_item,0.85,"[""reference content label: 17. Davidson JF, Burkhart SS, Richards DP, Campbell SE. Use ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,15,reference_content,"18. Sugaya H, Maeda K, Matsuki K, Moriishi J. Functional and structural outcome after arthroscopic full-thickness rotator cuff repair: single row versus dual-row fixation. Arthroscopy 2005; 21:1307–13","[459.0, 407.0, 782.0, 490.0]",reference_item,0.85,"[""reference content label: 18. Sugaya H, Maeda K, Matsuki K, Moriishi J. Functional and""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,16,reference_content,"19. Lee JE, Park JS, Ryu KN, et al. Repaired supraspinatus tendons in clinically improving patients: early postoperative findings and interval changes on MRI. Korean J Radiol 2015; 16:363–371","[459.0, 495.0, 782.0, 578.0]",reference_item,0.85,"[""reference content label: 19. Lee JE, Park JS, Ryu KN, et al. Repaired supraspinatus t""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,17,reference_content,"20. Meyer DC, Wieser K, Farshad M, Gerber C. Retraction of supraspinatus muscle and tendon as predictors of success of rotator cuff repair. Am J Sports Med 2012; 40:2242–2247","[458.0, 583.0, 782.0, 666.0]",reference_item,0.85,"[""reference content label: 20. Meyer DC, Wieser K, Farshad M, Gerber C. Retraction of s""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,18,reference_content,"21. Kim JH, Hong IT, Ryu KJ, Bong ST, Lee YS, Kim JH. Retear rate in the late postoperative period after arthroscopic rotator cuff repair. Am J Sports Med 2014; 42:2606–2613","[457.0, 671.0, 783.0, 754.0]",reference_item,0.85,"[""reference content label: 21. Kim JH, Hong IT, Ryu KJ, Bong ST, Lee YS, Kim JH. Retear""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,19,reference_content,"22. Gulotta LV, Nho SJ, Dodson CC, Adler RS, Altchek DW, MacGillivray JD. Prospective evaluation of arthroscopic rotator cuff repairs at 5 years. Part II. Prognostic factors for clinical and radiograp","[456.0, 759.0, 784.0, 885.0]",reference_item,0.85,"[""reference content label: 22. Gulotta LV, Nho SJ, Dodson CC, Adler RS, Altchek DW, Mac""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,20,reference_content,"23. Kim SJ, Kim SH, Lee SK, Seo JW, Chun YM. Arthroscopic repair of massive contracted rotator cuff tears: aggressive release with anterior and posterior interval slides do not improve cuff healing an","[456.0, 891.0, 783.0, 996.0]",reference_item,0.85,"[""reference content label: 23. Kim SJ, Kim SH, Lee SK, Seo JW, Chun YM. Arthroscopic re""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,21,reference_content,"24. Levy O, Relwani J, Zaman T, Even T, Venkateswaran","[455.0, 1000.0, 783.0, 1019.0]",reference_item,0.85,"[""reference content label: 24. Levy O, Relwani J, Zaman T, Even T, Venkateswaran""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,22,reference_content,"B, Copeland S. Measurement of blood flow in the rotator cuff using laser Doppler flowmetry. J Bone Joint Surg Br 2008; 90:893–898","[822.0, 143.0, 1130.0, 204.0]",reference_item,0.85,"[""reference content label: B, Copeland S. Measurement of blood flow in the rotator cuff""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +8,23,reference_content,"25. Liem D, Lichtenberg S, Magosch P, Habermeyer P. Magnetic resonance imaging of arthroscopic supraspinatus tendon repair. J Bone Joint Surg Am 2007; 89:1770–1776","[805.0, 209.0, 1131.0, 292.0]",reference_item,0.85,"[""reference content label: 25. Liem D, Lichtenberg S, Magosch P, Habermeyer P. Magnetic""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,24,reference_content,"26. Thomazeau H, Boukobza E, Morcet N, Chaperon J, Langlais F. Prediction of rotator cuff repair results by magnetic resonance imaging. Clin Orthop Relat Res 1997; 344:775–783","[805.0, 297.0, 1131.0, 380.0]",reference_item,0.85,"[""reference content label: 26. Thomazeau H, Boukobza E, Morcet N, Chaperon J, Langlais ""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True +8,25,reference_content,"27. Lakemeier S, Reichelt JJ, Patzer T, Fuchs-Winkelmann S, Paletta JR, Schofer MD. The association between retraction of the torn rotator cuff and increasing expression of hypoxia inducible factor 1α","[806.0, 385.0, 1131.0, 534.0]",reference_item,0.85,"[""reference content label: 27. Lakemeier S, Reichelt JJ, Patzer T, Fuchs-Winkelmann S, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,26,reference_content,"28. Thomazeau H, Rolland Y, Lucas C, Duval JM, Langlais F. Atrophy of the supraspinatus belly: assessment by MRI in 55 patients with rotator cuff pathology. Acta Orthop Scand 1996; 67:264–268","[804.0, 539.0, 1132.0, 623.0]",reference_item,0.85,"[""reference content label: 28. Thomazeau H, Rolland Y, Lucas C, Duval JM, Langlais F. A""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,27,reference_content,"29. Hodgson RJ, O'Connor PJ, Grainger AJ. Tendon and ligament imaging. Br J Radiol 2012; 85:1157–1172","[805.0, 627.0, 1130.0, 667.0]",reference_item,0.85,"[""reference content label: 29. Hodgson RJ, O'Connor PJ, Grainger AJ. Tendon and ligamen""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,28,reference_content,"30. Chang A, Miller TT. Imaging of tendons. Sports Health 2009; 1:293–300","[805.0, 671.0, 1130.0, 710.0]",reference_item,0.85,"[""reference content label: 30. Chang A, Miller TT. Imaging of tendons. Sports Health 20""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,29,reference_content,"31. Chung SW, Kim JY, Kim MH, Kim SH, Oh JH. Arthroscopic repair of massive rotator cuff tears: outcome and analysis of factors associated with healing failure or poor postoperative function. Am J Spo","[805.0, 715.0, 1131.0, 820.0]",reference_item,0.85,"[""reference content label: 31. Chung SW, Kim JY, Kim MH, Kim SH, Oh JH. 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This study aimed to find independent prognostic factors related to re", + "found_in_fulltext": true, + "fulltext_offset": 384 + }, + { + "block_id": "p1:15", + "page": 1, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "MATERIALS AND METHODS. Shoulder MR images were retrospectively analyzed for 83 p", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:16", + "page": 1, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "RESULTS. The overall retear rate was 57.8%. Significant differences were observe", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:17", + "page": 1, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "CONCLUSION. The retear rate of repaired rotator cuff tendon was about 57.8%. Ind", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:19", + "page": 1, + "role": "non_body_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "otator cuff tear is a common cause of shoulder joint pain, and MRI has high sens", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:20", + "page": 1, + "role": "non_body_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "specificity in the diagnosis of ro tator cuff tears [1]. 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There were 28 men", + "found_in_fulltext": true, + "fulltext_offset": 1555 + }, + { + "block_id": "p2:11", + "page": 2, + "role": "unknown_structural", + "zone": "frontmatter_side_zone", + "render_default": false, + "snippet": "MRI Examinations", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:12", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The mean time between preoperative MRI to operation was 17.2 days (range, 0–86 d", + "found_in_fulltext": true, + "fulltext_offset": 1650 + }, + { + "block_id": "p2:13", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A 3-T imaging unit (Achieva, Philips Healthcare) equipped with a dedicated shoul", + "found_in_fulltext": true, + "fulltext_offset": 1902 + }, + { + "block_id": "p2:14", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "gap, 0.5 mm), and oblique sagittal turbo spin-echo T2-weighted (FOV, 140 × 140 m", + "found_in_fulltext": true, + "fulltext_offset": 2919 + }, + { + "block_id": "p2:15", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The sequences and parameters of the postoperative MRI were as follows: axial tur", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:16", + "page": 2, + "role": "unknown_structural", + "zone": "frontmatter_side_zone", + "render_default": false, + "snippet": "MR Image Interpretation", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:17", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "At preoperative MRI, type of the supraspinatus tendon tear, extent of retraction", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:18", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Two radiologists with 30 and 5 years of experience in musculoskeletal imaging pa", + "found_in_fulltext": true, + "fulltext_offset": 3282 + }, + { + "block_id": "p2:19", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Full-thickness full-width tear of the supraspinatus tendon was defined as a comp", + "found_in_fulltext": true, + "fulltext_offset": 3873 + }, + { + "block_id": "p2:20", + "page": 2, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "AJR:210, January 2018", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:21", + "page": 2, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "135", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:0", + "page": 3, + "role": "noise", + "zone": "frontmatter_side_zone", + "render_default": false, + "snippet": "Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:1", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Shin et al.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:4", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "spinatus portion of the tear was included in the measurement (Fig. 3). The signa", + "found_in_fulltext": true, + "fulltext_offset": 4685 + }, + { + "block_id": "p3:7", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "native because our institution's routine protocol did not include sagittal T1-we", + "found_in_fulltext": true, + "fulltext_offset": 5621 + }, + { + "block_id": "p3:8", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Postoperative cuff integrity was classified into five categories according to th", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:9", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "compared with normal cuff, but without disconti- nuity, suggesting a partial-thi", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:10", + "page": 3, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Statistical Analysis", + "found_in_fulltext": true, + "fulltext_offset": 5956 + }, + { + "block_id": "p3:11", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "All continuous variables were tested for normality with the Kolmogorov-Smirnov a", + "found_in_fulltext": true, + "fulltext_offset": 5977 + }, + { + "block_id": "p3:12", + "page": 3, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Results", + "found_in_fulltext": true, + "fulltext_offset": 6983 + }, + { + "block_id": "p3:13", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Retear Rate of Repaired Rotator Cuff According to Sugaya Classification", + "found_in_fulltext": true, + "fulltext_offset": 6991 + }, + { + "block_id": "p3:14", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "According to the classification scheme by Sugaya et al. [18], the repaired supra", + "found_in_fulltext": true, + "fulltext_offset": 7063 + }, + { + "block_id": "p3:19", + "page": 3, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "A, 62-year-old man with type I tear. Tear edge (arrowhead) of supraspinatus tend", + "found_in_fulltext": true, + "fulltext_offset": 7152 + }, + { + "block_id": "p3:20", + "page": 3, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "B. 74-year-old woman with type II tear. Tear edge (arrowhead) of supraspinatus t", + "found_in_fulltext": true, + "fulltext_offset": 7285 + }, + { + "block_id": "p3:21", + "page": 3, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "C. 67-year-old woman with type III tear. Tear edge (arrowhead) of supraspinatus ", + "found_in_fulltext": true, + "fulltext_offset": 7408 + }, + { + "block_id": "p3:22", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "136", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:23", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "AJR:210, January 2018", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:0", + "page": 4, + "role": "noise", + "zone": "frontmatter_side_zone", + "render_default": false, + "snippet": "Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:1", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Retear of Repaired Rotator Cuff Tear Seen at MRI", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:2", + "page": 4, + "role": "figure_caption_candidate", + "zone": "body_zone", + "render_default": false, + "snippet": "TABLE I: Classification of Rotator Cuff Integrity Seen at MRI After Surgery", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:3", + "page": 4, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
Sugaya ClassificationNo. (%) of Patients ( $ n = 83 $)
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz
Medial tibial plateau$ 9.8 \pm 1.1 $$ 9.7 \pm 0.8 $ $ ^{a} $
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz
Medial tibial plateau$ 217 \pm 11^{a} $$ 189 \pm 14^{b,c} $","[107.0, 1026.0, 1117.0, 1159.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,11,vision_footnote,Univariate ANOVA test. $ ^{a} $Medial tibial plateau versus other sites $ (p<0.0005) $. $ ^{b} $PEMF-treated at 37 Hz and PEMF-treated at 75 Hz versus Sham-treated $ (p<0.0005) $. $ ^{c} $PEMF-treat,"[108.0, 1162.0, 1122.0, 1203.0]",footnote,0.7,"[""vision_footnote label: Univariate ANOVA test. $ ^{a} $Medial tibial plateau versus ""]",footnote,0.7,body_zone,body_like,none,True,True +5,12,figure_title,"Table 3. Subchondral Bone Thickness (SBT) Results of Sham-Treated and PEMF-Treated at 37 and 75 Hz Groups at Four Measurement Sites (Mean ± SD, n = 10)","[107.0, 1247.0, 1119.0, 1293.0]",table_caption,0.9,"[""table prefix matched: Table 3. Subchondral Bone Thickness (SBT) Results of Sham-Tr""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,13,table,
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz
Medial tibial plateau447 $ \pm $ 11328 $ \pm $ 52 $ ^{b} $
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz $ ^{a,b} $
Medial tibial plateau $ ^{c} $270 $ \pm $ 5297 $ \pm $ ","[65.0, 170.0, 1075.0, 304.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,vision_footnote,Multiple comparison Bonferroni's test. $ ^{a} $PEMF-treated at 75 Hz versus Sham-treated $ (p<0.0005) $. $ ^{b} $PEMF-treated at 75 Hz versus PEMF-treated at 37 Hz $ (p=0.001) $. $ ^{c} $Medial tibi,"[66.0, 304.0, 1079.0, 366.0]",footnote,0.7,"[""vision_footnote label: Multiple comparison Bonferroni's test. $ ^{a} $PEMF-treated ""]",footnote,0.7,body_zone,body_like,none,True,True +6,5,text,"this frequency preserves the cartilage from the progressive reduction of its thickness, which is typical of OA. Conversely, at 37 Hz, PEMFs did not significantly affect cartilage thickness. These find","[64.0, 415.0, 560.0, 576.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,text,"Regarding bone, in the present work, both PEMF frequencies avoided the phenomenon of bone sclerosis as confirmed by significantly lower SBT values in treated animals in comparison to the control group","[64.0, 576.0, 561.0, 878.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"nant with a reduction in SBT, whereas in the later +ones, bone formation took over.34 However, discordant +results have been reported when histomorphometry +was applied to SBT and epiphyseal trabecular b","[582.0, 415.0, 1081.0, 737.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,"After assessing the percentage variations of each considered histomorphometric parameter, an interesting comparison between this study with the authors two previous studies $ ^{25,26} $ was possible a","[582.0, 737.0, 1080.0, 879.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,figure_title,"Table 5. Histomorphometric Results of Epiphyseal Femoral and Tibial Bone for Sham-Treated and PEMF-Treated at 37 and 75 Hz Groups (Mean ± SD, n = 10)","[65.0, 941.0, 1080.0, 988.0]",table_caption,0.9,"[""table prefix matched: Table 5. Histomorphometric Results of Epiphyseal Femoral and""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,10,table,"
ParametersGroupsMedial Tibial Plateau $ ^{*,,\#} $Medial Femoral Condyle $ ^{*,,\#} $Lateral Tibial Plateau $ ^{*,} $Lateral Femoral Condyle","[62.0, 995.0, 1072.0, 1324.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,11,vision_footnote,Multiple comparison Bonferroni's test. BV/TV: *Medial tibial plateau and medial femoral condyle versus lateral tibial plateau and lateral femoral condyle (p = 0.001): each medial compartment versus al,"[65.0, 1328.0, 1079.0, 1476.0]",footnote,0.7,"[""vision_footnote label: Multiple comparison Bonferroni's test. BV/TV: *Medial tibial""]",footnote,0.7,body_zone,body_like,none,True,True +6,12,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[67.0, 1503.0, 405.0, 1523.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,header,PEMF FREQUENCY RESPONSE IN OA,"[739.0, 67.0, 1056.0, 89.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,683,"[1083.0, 68.0, 1119.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,"21, $ ^{26} $ and 24 months old. This analysis indicated that in the later OA stage of the present work, PEMFs were still effective at counteracting the progression of OA, but with greater positive ef","[105.0, 115.0, 602.0, 508.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"The spontaneous OA model used has been already well characterized and shown to be a reliable model for the study of knee OA. Degenerative changes, similar to humans, of either articular cartilage or s","[105.0, 507.0, 602.0, 805.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"As observed in the SHAM animals of the current study, in this late OA stage (21 months old) the medial tibial plateau showed the worst values in FI and cartilage histological grading score parameters,","[106.0, 805.0, 602.0, 992.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"ison with the SHAM animals of the other two previous +studies25,26 (data not shown), thus confirming the +severity of OA stage. +I h li h ifi i di i","[625.0, 117.0, 1120.0, 187.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"In the literature, there are no specific indications about the length of exposure, duration, and how long PEMF should be applied to subjects. In an in vitro study, De Mattei et al. $ ^{18} $ observed ","[623.0, 187.0, 1122.0, 991.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,figure_title,A,"[146.0, 1028.0, 173.0, 1054.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,8,chart,,"[147.0, 1037.0, 600.0, 1330.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,9,figure_title,B,"[622.0, 1027.0, 647.0, 1053.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,10,chart,,"[623.0, 1057.0, 1078.0, 1329.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,11,figure_title,"Figure 2. (A) Percentage variation of Cartilage Histological Score, FI, cartilage thickness, SBT results measured in the medial tibial plateau of the PEMF-treated at 75 Hz group and Sham-treated group","[107.0, 1342.0, 1121.0, 1477.0]",figure_caption,0.92,"[""figure_title label: Figure 2. (A) Percentage variation of Cartilage Histological""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,12,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[783.0, 1504.0, 1119.0, 1522.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,0,number,684,"[69.0, 69.0, 105.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,VERONESI ET AL.,"[135.0, 68.0, 286.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,text,"present study, it can only be hypothesized that this frequency exerted a stronger anti-inflammatory effect thus reducing catabolic mediators and increasing anabolic cytokine concentration.","[66.0, 118.0, 558.0, 209.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,The second limitation is that microtomographic analyses of the subchondral bone changes were not performed but were analyzed by histomorphometry which is strongly correlated with micro-CT measurements,"[65.0, 210.0, 559.0, 323.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,CONCLUSIONS,"[67.0, 345.0, 225.0, 367.0]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSIONS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +8,5,text,"Although the use of different frequencies should not affect patient compliance to therapy, it was interesting to verify if a lower frequency may eventually reproduce the same biological effects of the","[65.0, 370.0, 559.0, 621.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"PEMFs are a local treatment and cannot be expected to treat OA in all joints. Nevertheless, OA located at specific joints, most frequently knee and hip, has a severe impact on patients' lives and requ","[66.0, 622.0, 559.0, 852.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,paragraph_title,ACKNOWLEDGMENTS,"[68.0, 873.0, 291.0, 894.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +8,8,text,"The study was funded by “Prevenzione e cura dell'osteoartite: Patogenesi e terapie alternative” project, Monte Paschi di Siena foundation and Rizzoli Orthopedic Institute (MetaLab Research foundation)","[66.0, 896.0, 558.0, 1024.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,paragraph_title,REFERENCES,"[69.0, 1049.0, 193.0, 1071.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +8,10,reference_content,"1. Sophia Fox AJ, Bedi A, Rodeo SA. 2009. The basic science of articular cartilage: structure, composition, and function. Sports Health 1:461–468.","[79.0, 1074.0, 557.0, 1131.0]",reference_item,0.85,"[""reference content label: 1. Sophia Fox AJ, Bedi A, Rodeo SA. 2009. The basic science ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,11,reference_content,"2. Neogi T, Zhang Y. 2013. Epidemiology of osteoarthritis. Rheum Dis Clin North Am 39:1–19.","[80.0, 1133.0, 555.0, 1171.0]",reference_item,0.85,"[""reference content label: 2. Neogi T, Zhang Y. 2013. Epidemiology of osteoarthritis. R""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,12,reference_content,"3. Herrero-Beaumont G, Roman-Blas JA, Castaneda S, et al. 2009. Primary osteoarthritis no longer primary: Three subsets with distinct etiological, clinical and therapeutic characteristics. Semin Arthr","[82.0, 1173.0, 556.0, 1251.0]",reference_item,0.85,"[""reference content label: 3. Herrero-Beaumont G, Roman-Blas JA, Castaneda S, et al. 20""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,13,reference_content,"4. De Mattei M, Varani K, Masieri FF, et al. 2009. Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts. Osteoarthritis Cartilage 17:252–262.","[81.0, 1253.0, 557.0, 1330.0]",reference_item,0.85,"[""reference content label: 4. De Mattei M, Varani K, Masieri FF, et al. 2009. Adenosine""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,14,reference_content,"5. Veronesi F, Giavaresi G, Tschon M, et al. 2013. Clinical use of bone marrow, bone marrow concentrate and expanded bone marrow mesenchymal stem cells in cartilage disease. Stem Cell Dev 22:181–192.","[81.0, 1333.0, 557.0, 1409.0]",reference_item,0.85,"[""reference content label: 5. Veronesi F, Giavaresi G, Tschon M, et al. 2013. Clinical ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,15,reference_content,"6. Ryang We S, Koog YH, Jeong KI, et al. 2013. Effects of pulsed electromagnetic field on knee osteoarthritis: a systematic review. Rheumatology 52:815–824.","[80.0, 1412.0, 558.0, 1470.0]",reference_item,0.85,"[""reference content label: 6. Ryang We S, Koog YH, Jeong KI, et al. 2013. Effects of pu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,16,reference_content,"7. Varani K, De Mattei M, Vincenzi F, et al. 2008. Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromag","[600.0, 118.0, 1078.0, 215.0]",reference_item,0.85,"[""reference content label: 7. Varani K, De Mattei M, Vincenzi F, et al. 2008. Character""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True +8,17,reference_content,"8. De Mattei M, Pellati A, Pasello M, et al. 2004. Effects of physical stimulation with electromagnetic field and insulin growth factor-I treatment on proteoglycan synthesis of bovine articular cartil","[598.0, 217.0, 1078.0, 313.0]",reference_item,0.85,"[""reference content label: 8. De Mattei M, Pellati A, Pasello M, et al. 2004. Effects o""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True +8,18,reference_content,"9. Ongaro A, Pellati A, Masieri FF, et al. 2011. Chondroprotective effects of pulsed electromagnetic fields on human cartilage explants. Bioelectromagnetics 32:543–551.","[599.0, 317.0, 1076.0, 375.0]",reference_item,0.85,"[""reference content label: 9. Ongaro A, Pellati A, Masieri FF, et al. 2011. 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When such interaction was significant, univariate ANO", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:14", + "page": 3, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "RESULTS", + "found_in_fulltext": true, + "fulltext_offset": 9531 + }, + { + "block_id": "p3:15", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Histological images of medial femoral and tibial plateau showed the presence of ", + "found_in_fulltext": true, + "fulltext_offset": 9539 + }, + { + "block_id": "p3:16", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In the medial tibial plateau, the PEMF-treated at 75 Hz group showed a significa", + "found_in_fulltext": true, + "fulltext_offset": 10367 + }, + { + "block_id": "p3:17", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The FI value was significantly reduced by PEMFs versus control $ (p < 0.0005) $ ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:18", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Both PEMF treatments significantly reduced the SBT in almost all the knee areas,", + "found_in_fulltext": true, + "fulltext_offset": 11366 + }, + { + "block_id": "p3:19", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Cartilage thickness did not show interaction between treatment and site factors ", + "found_in_fulltext": true, + "fulltext_offset": 11716 + }, + { + "block_id": "p3:20", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:0", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "680", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:1", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "VERONESI ET AL.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:15", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "observed in the medial tibial plateau than in all the other sites $ (p<0.0005) $", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:16", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Regarding the histomorphometric results of epiphyseal femoral and tibial bone (T", + "found_in_fulltext": true, + "fulltext_offset": 12306 + }, + { + "block_id": "p4:17", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "in all groups. Nevertheless, each medial compartment had significantly higher val", + "found_in_fulltext": true, + "fulltext_offset": 12933 + }, + { + "block_id": "p4:18", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:0", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "PEMF FREQUENCY RESPONSE IN OA", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:1", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "681", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:2", + "page": 5, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 1. 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Sham-TreatedPEMF-Treated at 37 HzPEMF-", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:4", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Univariate ANOVA test. Medial tibial plateau versus lateral tibial plateau and l", + "found_in_fulltext": true, + "fulltext_offset": 13404 + }, + { + "block_id": "p5:5", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "comparison to the lateral ones ($p<0.0005$). Both PEMFs significantly decreased ", + "found_in_fulltext": true, + "fulltext_offset": 13718 + }, + { + "block_id": "p5:6", + "page": 5, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "DISCUSSION", + "found_in_fulltext": true, + "fulltext_offset": 14419 + }, + { + "block_id": "p5:7", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The aim of the present study was to investigate firstly the effect of 75 Hz PEMF", + "found_in_fulltext": true, + "fulltext_offset": 14430 + }, + { + "block_id": "p5:8", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "biological effects. Current results highlighted that PEMFs at 75 Hz were more ef", + "found_in_fulltext": true, + "fulltext_offset": 14744 + }, + { + "block_id": "p5:9", + "page": 5, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 2. Fibrillation Index (FI) Results of Sham-Treated and PEMF-Treated at 37 ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:10", + "page": 5, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
Sham-TreatedPEMF-Treated at 37 HzPEMF-", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:11", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Univariate ANOVA test. $ ^{a} $Medial tibial plateau versus other sites $ (p<0.0", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:12", + "page": 5, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 3. Subchondral Bone Thickness (SBT) Results of Sham-Treated and PEMF-Treat", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:14", + "page": 5, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Univariate ANOVA test. $ ^{a} $Medial femoral condyle versus other sites (p < 0.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:15", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:0", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "682", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:1", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "VERONESI ET AL.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:2", + "page": 6, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 4. Cartilage Thickness Values of Sham-Treated and PEMF-Treated at 37 and 7", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:3", + "page": 6, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
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Histomorphometric Results of Epiphyseal Femoral and Tibial Bone for Sha", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:11", + "page": 6, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Multiple comparison Bonferroni's test. 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"p19:71" + ], + "findings": [ + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_019.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:2", + "p1:3", + "p1:4", + "p1:9", + "p1:10", + "p1:14", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p2:0", + "p2:2", + "p2:4", + "p2:12", + "p2:13", + "p2:14", + "p2:15", + "p3:0", + "p3:2" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/3MPHY9LD/audit_report.md b/audit/3MPHY9LD/audit_report.md new file mode 100644 index 00000000..6c412e9d --- /dev/null +++ b/audit/3MPHY9LD/audit_report.md @@ -0,0 +1,17 @@ +# OCR Truth Audit Report - 3MPHY9LD + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19] +- Reviewed blocks: 422 + +## Findings + +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git 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label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,www.advancedscience.com,"[887.0, 97.0, 1097.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,doc_title,Machine Learning-Enhanced Optimization for High-Throughput Precision in Cellular Droplet Bioprinting,"[96.0, 148.0, 1063.0, 241.0]",paper_title,0.8,"[""page-1 zone title_zone: Machine Learning-Enhanced Optimization for High-Throughput P""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Jaemyung Shin, Ryan Kang, Kinam Hyun, Zhangkang Li, Hitendra Kumar, Kangsoo Kim, Simon S. Park, and Keekyoung Kim*","[91.0, 269.0, 1089.0, 338.0]",authors,0.8,"[""page-1 zone author_zone: Jaemyung Shin, Ryan Kang, Kinam Hyun, Zhangkang Li, Hitendra""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,abstract,"Organoids produce through traditional manual pipetting methods face challenges such as labor-intensive procedures and batch-to-batch variability in quality. To ensure consistent organoid production, 3","[95.0, 400.0, 740.0, 899.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,7,paragraph_title,1. Introduction,"[98.0, 962.0, 247.0, 987.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,8,text,"Bioprinting has the potential to replace 2D cell cultures by more closely replicating the 3D microtissue environment. $ ^{[1,2]} $ Moreover, its versatility enables a broad spectrum of applications, s","[95.0, 999.0, 588.0, 1091.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,text,"transplantation, $ ^{[5]} $ pharmaceuticals and high-throughput screening, $ ^{[6]} $ and cancer research. $ ^{[7]} $ Among many types of bioprinting, pneumatic extrusion bioprinting offers significan","[763.0, 387.0, 1099.0, 957.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,10,text,"et al. utilized inkjet bioprinting to create droplet-shaped structures with a gelatin methacrylate (GelMA) hydrogel precursor combined with cells, analyzing cell responses to an elastic composite subs","[605.0, 959.0, 1099.0, 1045.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,11,text,The common challenges frequently encountered in these studies include the intricate process of achieving consistent,"[605.0, 1046.0, 1100.0, 1091.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,12,footnote,"J. Shin, Z. Li, K. Kim +Department of Biomedical Engineering +Schulich School of Engineering +University of Calgary +Calgary, Alberta T2N 1N4, Canada +E-mail: keekyoung.kim@ucalgary.ca","[97.0, 1138.0, 367.0, 1250.0]",footnote,0.7,"[""footnote label: J. Shin, Z. Li, K. Kim\nDepartment of Biomedical Engineering\n""]",footnote,0.7,body_zone,body_like,none,True,True +1,13,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/advs.202412831,"[97.0, 1295.0, 588.0, 1336.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,14,footnote,"R. Kang, K. Kim +Department of Electrical and Software Engineering +Schulich School of Engineering +University of Calgary +Calgary, Alberta T2N 1N4, Canada","[606.0, 1139.0, 954.0, 1234.0]",footnote,0.7,"[""footnote label: R. Kang, K. Kim\nDepartment of Electrical and Software Engine""]",footnote,0.7,body_zone,body_like,none,True,True +1,15,footnote,"© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and repr","[95.0, 1339.0, 588.0, 1413.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2025 The Author(s). Advanced Science published by Wiley-VC""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,16,footnote,"K. Hyun, S. S. Park, K. Kim +Department of Mechanical and Manufacturing Engineering +Schulich School of Engineering +University of Calgary +Calgary, Alberta T2N 1N4, Canada +H. Kumar +Department of Bioscien","[606.0, 1234.0, 1004.0, 1403.0]",footnote,0.7,"[""footnote label: K. Hyun, S. S. Park, K. 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Advanced Science published by Wiley-VCH GmbH,"[663.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[931.0, 32.0, 1089.0, 90.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +2,2,header,www.advancedscience.com,"[881.0, 97.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,text,"microscale droplets of uniform size. Additionally, optimizing numerous bioprinting parameters, such as temperature, bioink properties, printing time, printing speed, nozzle size, and dispensing pressu","[89.0, 149.0, 582.0, 1049.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,4,text,"In this study, we developed a novel bioprinter designed to address the challenges of high-throughput and precise 3D cellular droplet bioprinting. The system is equipped with a large-scale data collect","[89.0, 1048.0, 582.0, 1268.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"The combination of ML with advanced bioprinting technology can potentially accelerate research in tissue engineering and precision medicine.[23] ML refers to computer programs that based on big data, ","[89.0, 1267.0, 582.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"ing the inkjet-based bioprinting process.[25] However, the au- +thors noted that additional experiments are required to collect +a broader range of parameters for further improvement. In the +development","[599.0, 149.0, 1093.0, 567.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"To provide users with enhanced controllability and printability, we established a high-throughput bioprinting platform incorporating data-driven traditional ML and DL for bioprinting the array of cell","[599.0, 565.0, 1093.0, 1028.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,2. Results,"[602.0, 1053.0, 704.0, 1079.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,paragraph_title,2.1. Mechanical and Physiochemical Properties Investigation of GelMA-Alginate Bioinks,"[600.0, 1091.0, 1081.0, 1137.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Mechanical and Physiochemical Properties Investigation ""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +2,10,text,Achieving a successful bioprinted scaffold depends on biomaterials with optimized rheological properties. Rheological assessments were conducted on various biomaterial combinations to evaluate their s,"[598.0, 1157.0, 1092.0, 1312.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,text,"Figure 2a illustrates the rheological behavior of various GelMA-alginate compositions during the photocrosslinking process. The bioinks used in this study are designated as 5G, 5G0.5A, 5G1A, and 5G2A,","[599.0, 1311.0, 1093.0, 1445.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 2a illustrates the rheological behavior of various Ge""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +2,12,footer,"Adv. Sci. 2025, 12, 2412831","[93.0, 1487.0, 254.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,13,footer,2412831 (2 of 20),"[389.0, 1484.0, 523.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,14,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657.0, 1487.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,15,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://onlinel","[1153.0, 30.0, 1172.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[97.0, 46.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[932.0, 32.0, 1094.0, 105.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,2,header,www.advancedscience.com,"[887.0, 97.0, 1096.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,3,image,,"[235.0, 152.0, 962.0, 421.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,image,,"[245.0, 458.0, 870.0, 716.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,5,figure_title,"Figure 1. Overview of machine learning types and neural network structures. a) Machine learning encompasses various approaches, including supervised learning (e.g., regression and classification), uns","[96.0, 723.0, 1100.0, 782.0]",figure_caption,0.92,"[""figure_title label: Figure 1. Overview of machine learning types and neural netw""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,6,text,GelMA. These notations are used consistently throughout the manuscript to describe the GelMA-alginate formulations.,"[95.0, 828.0, 587.0, 872.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"The 5% (w/v) GelMA (5G) formulation exhibited the highest storage modulus upon light exposure, indicating superior elastic properties and robust network formation. This suggests that the 5G precursor ","[95.0, 872.0, 588.0, 1268.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"As the alginate concentration increased, the loss modulus appeared to slightly increase (Figure 2b). This trend aligns with the decrease in storage modulus, as the alginate is thought to interfere wit","[95.0, 1267.0, 588.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"with the crosslinking process, resulting in a more gradual transi- +tion from viscous to elastic behavior. The initial loss modulus (be- +fore initiating the light exposure) tends to be higher for sampl","[604.0, 828.0, 1098.0, 1070.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"As shown in Figure 2c, the storage modulus remains relatively constant across a range of angular frequencies, indicating that the material has formed a stable and elastic network. All materials used i","[604.0, 1071.0, 1098.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,text,"Additionally, the static viscosity of the material, a critical bio-printing parameter, was investigated. During this measurement, a fluid typically exhibits a viscosity plateau at lower shear rates.","[605.0, 1377.0, 1098.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,footer,"Adv. 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Rheological, mechanical, and physical characterization of GelMA-alginate hydrogels. a) Storage modulus measured at the initiation of light exposure after 60 sec. b) Loss modulus measured at ","[91.0, 747.0, 1089.0, 845.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Rheological, mechanical, and physical characteriza""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,19,text,"and then displays shear thinning as the shear rate increases, forming a flow curve. Alginate, a high molecular weight polysaccharide, increases the average molecular weight of the entire hydrogel prec","[89.0, 872.0, 582.0, 1113.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,20,text,"To evaluate the transparency, the logo remained visible in the 5G and 5G0.5A samples (Figure 2e). Conversely, the 5G1A sample showed reduced visibility of the logo, while the 5G2A sample exhibited com","[90.0, 1113.0, 581.0, 1266.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,21,text,"As the alginate concentration increases, the initial mechanical strength of the hydrogel is enhanced. However, excessive alginate concentrations may interfere with the photocrosslinking of GelMA. Figu","[89.0, 1267.0, 582.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,22,text,"Due to alginate’s high hydrophilicity, its incorporation into +GelMA enhances the hydrogel network’s porosity, generally lead- +ing to an increased swelling ratio.[35,36] As shown in Figure 2g, +the swel","[599.0, 872.0, 1092.0, 982.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,23,paragraph_title,2.2. Development and Validation of the Developed Bioprinting Platform,"[600.0, 1027.0, 1070.0, 1071.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Development and Validation of the Developed Bioprinting""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,24,text,A conversion of a commercially available 3D printer into a bioprinter is detailed in Shin et al. $ ^{[12]} $. This modified system was based on a low-cost 3-axis fused deposition modeling printer (End,"[599.0, 1091.0, 1092.0, 1356.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,25,text,"To accommodate the data-intensive nature of ML training, a movable printing stage along with additional modifications was incorporated into the original 3D bioprinting platform (Figure 3a). The G-code","[600.0, 1356.0, 1093.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,26,footer,"Adv. Sci. 2025, 12, 2412831","[93.0, 1487.0, 254.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,27,footer,2412831 (4 of 20),"[389.0, 1484.0, 523.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,28,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657.0, 1487.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,29,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, China, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://","[1154.0, 29.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header_image,,"[930.0, 31.0, 1096.0, 115.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,2,figure_title,a,"[108.0, 152.0, 129.0, 174.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,3,image,,"[153.0, 154.0, 1043.0, 655.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,4,figure_title,b,"[109.0, 673.0, 130.0, 698.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,5,image,,"[100.0, 680.0, 559.0, 943.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,figure_title,C,"[575.0, 678.0, 597.0, 699.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,7,figure_title,d,"[820.0, 674.0, 843.0, 700.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,8,chart,,"[568.0, 717.0, 821.0, 986.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,9,chart,,"[836.0, 705.0, 1092.0, 934.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,10,figure_title,e,"[108.0, 997.0, 129.0, 1019.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,11,chart,,"[137.0, 1016.0, 502.0, 1233.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,12,figure_title,f,"[518.0, 992.0, 535.0, 1019.0]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,13,chart,,"[531.0, 1015.0, 897.0, 1234.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,figure_title,Figure 3. a) Modified and developed 3D bioprinting setup. b) Impact of in-syringe bioink homogenization on cell distribution and viability in bioprinted constructs. c) Comparison of bioprinted cell nu,"[95.0, 1243.0, 1099.0, 1341.0]",figure_caption,0.92,"[""figure_title label: Figure 3. a) Modified and developed 3D bioprinting setup. b)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,15,footer,"Adv. Sci. 2025, 12, 2412831","[98.0, 1487.0, 260.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,16,number,2412831 (5 of 20),"[395.0, 1484.0, 528.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,17,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,18,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1153.0, 28.0, 1172.0, 1531.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 45.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header_image,,"[931.0, 31.0, 1089.0, 90.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +6,2,header,www.advancedscience.com,"[882.0, 97.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,figure_title,"Table 1. Bioprinting parameters used to achieve the desired droplet volume include biomaterial viscosity, nozzle size, printing time, printing pressure, and cell concentration.","[90.0, 150.0, 1089.0, 191.0]",table_caption,0.9,"[""table prefix matched: Table 1. Bioprinting parameters used to achieve the desired ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,4,table,"
Independent variablesDependent variables
Viscosity (mPa·s)Nozzle size (I.D. $ ^{a} $) mm)Printing time (s)Printing press","[90.0, 204.0, 1089.0, 343.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,5,vision_footnote, $ ^{a)} $ I.D.: inner diameter,"[93.0, 346.0, 223.0, 368.0]",footnote,0.7,"[""vision_footnote label: $ ^{a)} $ I.D.: inner diameter""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +6,6,text,"stepper motor, shifting the printing linear stage to the right after each droplet deposition, thereby facilitating the acquisition of new cell-laden droplet image data (Movie S1, Supporting Informatio","[89.0, 399.0, 582.0, 926.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"In Figure 3b, the dispensed bioink was immediately crosslinked and imaged under a microscope at three time points: at the start of printing (T0), 30 min later (T30), and 60 min later (T60) (Movie S5, ","[88.0, 926.0, 583.0, 1232.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,The printed green fluorescent protein (GFP)-tagged 3T3 cell-laden droplets were produced in various sizes (up to 50 μL) on a 96-well plate. The fluorescence signal was measured at an absorbance of 492,"[88.0, 1232.0, 582.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"a higher number of cells (Figure 3d). This indicates that the de- +veloped bioprinting system not only produces uniform and sta- +ble droplets but also automates the data collection process, en- +abling ","[599.0, 399.0, 1093.0, 532.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"Additionally, this study focused on identifying and quantifying the relative importance of bioprinting parameters in determining the final volume of bioprinted droplets (Table 1). Using a systematic a","[598.0, 530.0, 1094.0, 1081.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,paragraph_title,2.3. Image Processing and Droplet Volume Calculation,"[600.0, 1102.0, 1013.0, 1125.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Image Processing and Droplet Volume Calculation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,12,text,"To achieve uniform droplet volume during bioprinting and maintain consistent printing conditions, the substrate of the glass slide was treated with a hydrophobic silane coating (Figure 4a). This treat","[598.0, 1145.0, 1093.0, 1434.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,13,footer,"Adv. Sci. 2025, 12, 2412831","[93.0, 1487.0, 254.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,14,footer,2412831 (6 of 20),"[389.0, 1484.0, 523.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,15,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657.0, 1487.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,16,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1153.0, 29.0, 1172.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +7,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 346.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header_image,,"[890.0, 31.0, 1096.0, 117.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +7,2,figure_title,a,"[109.0, 154.0, 130.0, 176.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,3,image,,"[102.0, 179.0, 432.0, 387.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,4,figure_title,b,"[430.0, 150.0, 452.0, 176.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,5,figure_title,C,"[664.0, 154.0, 685.0, 176.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,6,image,,"[442.0, 179.0, 753.0, 418.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,7,image,,"[763.0, 168.0, 1088.0, 412.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,8,figure_title,d,"[109.0, 417.0, 131.0, 443.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,9,vision_footnote,Raw images,"[133.0, 446.0, 258.0, 474.0]",footnote,0.7,"[""vision_footnote label: Raw images""]",footnote,0.7,body_zone,unknown_like,short_fragment,True,True +7,10,vision_footnote,Image processing,"[516.0, 446.0, 698.0, 476.0]",footnote,0.7,"[""vision_footnote label: Image processing""]",footnote,0.7,body_zone,unknown_like,short_fragment,True,True +7,11,vision_footnote,Contact Angle,"[922.0, 445.0, 1066.0, 475.0]",footnote,0.7,"[""vision_footnote label: Contact Angle""]",footnote,0.7,body_zone,unknown_like,short_fragment,True,True +7,12,image,,"[112.0, 511.0, 1083.0, 671.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,e,"[114.0, 682.0, 133.0, 705.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,14,image,,"[153.0, 721.0, 349.0, 908.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,15,figure_title,f,"[604.0, 682.0, 620.0, 709.0]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,16,image,,"[364.0, 713.0, 563.0, 909.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,17,chart,,"[630.0, 684.0, 955.0, 928.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,18,figure_title,g,"[106.0, 940.0, 128.0, 967.0]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,19,image,,"[120.0, 941.0, 978.0, 1256.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,20,figure_title,Figure 4. a) High-throughput bioprinting multiple cellular droplets during a single bioprinting run on a silane-coated glass slide. b) Demonstration of consistency in bioprinted GFP-tagged 3T3 fibrobl,"[96.0, 1264.0, 1099.0, 1401.0]",figure_caption,0.92,"[""figure_title label: Figure 4. a) High-throughput bioprinting multiple cellular d""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,21,footer,"Adv. Sci. 2025, 12, 2412831","[98.0, 1487.0, 260.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,22,number,2412831 (7 of 20),"[395.0, 1484.0, 528.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,23,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,24,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://onlinel","[1153.0, 29.0, 1172.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +8,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header_image,,"[931.0, 31.0, 1088.0, 90.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +8,2,header,www.advancedscience.com,"[882.0, 97.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"A micro ruler was placed at the droplet dispensing location to precisely measure the actual length of the droplet at the dispensing point, yielding a value of 10 mm. The corresponding pixel count for ","[89.0, 149.0, 582.0, 303.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"To outline the development of our custom droplet size calculation software, the image processing pipeline incorporates a series of techniques to enhance efficiency and accuracy. Precise edge detection","[89.0, 303.0, 582.0, 676.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"In Figure 4e, the manual droplet volume measurement was performed by analyzing the raw image in Figure 4d using ImageJ, where five points were manually placed along the droplet boundary and the volume","[89.0, 675.0, 582.0, 1140.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,display_formula, $$ \mathrm{V}=\frac{\pi D^{3}}{24}\left(\frac{2-3\cos\theta+\cos^{3}\theta}{\sin^{3}\theta}\right) $$ ,"[90.0, 1156.0, 340.0, 1205.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,7,formula_number,(1),"[557.0, 1170.0, 578.0, 1192.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,8,text,"where r is the radius of the droplet base (in mm), h is the height of the droplet (in mm), V is the calculated droplet volume (in $ \mu $L), and $ \theta $ is the contact angle between the droplet a","[90.0, 1223.0, 581.0, 1312.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,text,"Both measurements for this analysis were obtained from 10 randomly selected droplets from each size group (small, medium, and large), resulting in a total of 30 images. These images were chosen to val","[90.0, 1311.0, 582.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,text,"sure that the subset effectively captured the range of droplet sizes +observed in the full dataset. The analysis encompassed droplets +of various sizes: small droplets with a mean volume of 3.54 μL, +medi","[599.0, 150.0, 1092.0, 346.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,11,text,"By combining these processed images, we achieved reliable and consistent volume measurements across all samples, demonstrating the robustness of the proposed approach in capturing the fine details nec","[599.0, 347.0, 1093.0, 721.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,paragraph_title,2.4. Optimization of the Hyperparameters,"[601.0, 764.0, 920.0, 787.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Optimization of the Hyperparameters""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,13,text,"Optimal hyperparameter tuning is essential for maximizing the performance of traditional ML models. By leveraging various optimization methods, such as grid search, random search, Bayesian optimizatio","[600.0, 806.0, 1092.0, 960.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,14,text,"To evaluate the performance of the algorithms in predicting printing parameters, our study was structured into two distinct phases: Phase 1, focuses on hyperparameter optimization, and Phase 2, compar","[600.0, 961.0, 1093.0, 1224.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,text,An optimization process was conducted to determine the optimal hyperparameters for each algorithm. This process involved 10-fold cross-validation to identify the hyperparameters that yielded the best ,"[599.0, 1224.0, 1093.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,16,footer,"Adv. Sci. 2025, 12, 2412831","[93.0, 1487.0, 254.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,17,footer,2412831 (8 of 20),"[389.0, 1484.0, 523.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,18,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657.0, 1487.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,19,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://onlinel","[1153.0, 29.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 346.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header_image,,"[931.0, 31.0, 1096.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +9,2,figure_title,a,"[116.0, 156.0, 137.0, 179.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,3,chart,,"[103.0, 189.0, 371.0, 424.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,4,figure_title,b,"[408.0, 152.0, 430.0, 180.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,5,chart,,"[394.0, 194.0, 660.0, 421.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,figure_title,C,"[684.0, 156.0, 704.0, 180.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,7,chart,,"[679.0, 190.0, 952.0, 421.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,8,figure_title,d,"[117.0, 433.0, 140.0, 460.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,chart,,"[109.0, 457.0, 365.0, 691.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,10,figure_title,e,"[414.0, 437.0, 435.0, 459.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,11,chart,,"[383.0, 461.0, 659.0, 694.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,12,figure_title,f,"[122.0, 687.0, 140.0, 715.0]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,13,vision_footnote,"- Train MSE +-☑ Validation MSE +-☑ Train MAE +-☑ Validation MAE +-☑ Train RMSE +-☑ Validation RMSE +-☑ Train R-squared +-☑ Validation R-squared","[673.0, 469.0, 875.0, 660.0]",footnote,0.7,"[""vision_footnote label: - Train MSE\n-\u2611 Validation MSE\n-\u2611 Train MAE\n-\u2611 Validation MAE""]",footnote,0.7,body_zone,unknown_like,none,True,True +9,14,figure_title,g,"[411.0, 692.0, 434.0, 720.0]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,15,chart,,"[118.0, 716.0, 391.0, 954.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,16,figure_title,h,"[681.0, 687.0, 705.0, 715.0]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,17,chart,,"[404.0, 717.0, 662.0, 930.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,18,figure_title,i,"[132.0, 956.0, 147.0, 982.0]",figure_inner_text,0.9,"[""panel label / figure inner text: i""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,19,chart,,"[686.0, 727.0, 979.0, 955.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,20,figure_title,j,"[415.0, 956.0, 432.0, 988.0]",figure_inner_text,0.9,"[""panel label / figure inner text: j""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,21,chart,,"[104.0, 997.0, 422.0, 1228.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,22,chart,,"[412.0, 994.0, 702.0, 1225.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,23,figure_title,k,"[690.0, 956.0, 710.0, 983.0]",figure_inner_text,0.9,"[""panel label / figure inner text: k""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,24,chart,,"[697.0, 964.0, 1091.0, 1226.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,25,figure_title,Figure 5. a) Optimization process for identifying the optimized hyperparameters for a decision tree. b) Optimization process for identifying the optimized hyperparameters for a random forest. c) Optim,"[97.0, 1253.0, 1098.0, 1407.0]",figure_caption,0.92,"[""figure_title label: Figure 5. a) Optimization process for identifying the optimi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,26,footer,"Adv. Sci. 2025, 12, 2412831","[98.0, 1487.0, 260.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,27,number,2412831 (9 of 20),"[395.0, 1484.0, 528.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,28,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,29,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, China, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://","[1154.0, 29.0, 1171.0, 1532.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +10,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 45.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header_image,,"[930.0, 33.0, 1089.0, 93.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +10,2,header,www.advancedscience.com,"[881.0, 97.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,3,figure_title,Table 2. Computation times of three traditional machine learning algorithms and two deep learning algorithms using the dataset with optimized hyperparameter. Training and validation times are presente,"[91.0, 149.0, 581.0, 223.0]",table_caption,0.9,"[""table prefix matched: Table 2. Computation times of three traditional machine lear""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,4,table,,"[91.0, 240.0, 578.0, 395.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +10,5,text,"7, while the random forest (RF) demonstrated superior performance with 10 estimators (Figure 5b). Given the multitude of hyperparameters in RF, a systematic approach employing GridSearchCV, an automat","[89.0, 434.0, 582.0, 766.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,paragraph_title,2.5. Computation Time for Hyperparameter Optimization,"[90.0, 807.0, 523.0, 830.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Computation Time for Hyperparameter Optimization""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,7,text,Hyperparameter optimization often involves exploring numerous combinations of hyperparameters. The time required to evaluate each combination directly impacts the overall optimization process. Typical,"[89.0, 850.0, 582.0, 1180.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,text,"The complexity of the model, such as the depth of a neural network or the number of trees in an RF, directly impacts the duration of the training. More complex models require additional time to conver","[89.0, 1180.0, 583.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,9,text,"management can help balance the time requirements of these +phases, ultimately enabling more effective and timely model de- +velopment.","[600.0, 148.0, 1093.0, 216.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,paragraph_title,2.6. Comparative Evaluation of Machine Learning Algorithms for Droplet Volume Prediction,"[601.0, 255.0, 1087.0, 301.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Comparative Evaluation of Machine Learning Algorithms f""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,11,text,The hyperparameters identified as optimal during the initial optimization phase were applied to each algorithm. Each model was then subjected to a rigorous training and evaluation process involving 10,"[599.0, 321.0, 1093.0, 716.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,12,text,"Second, mean squared error (MSE) is calculated by averaging the squared differences between predicted and actual values. Lower MSE values indicate a closer alignment between model predictions and actu","[598.0, 715.0, 1093.0, 1067.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,13,text,"Third, RMSE mitigates the distortion caused by squaring the errors in MSE by taking the square root, making it more interpretable. Unlike MSE, RMSE provides a more intuitive measure of error in the sa","[599.0, 1066.0, 1093.0, 1157.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,14,figure_title,Table 3. Performance evaluation of three traditional machine learning algorithms and two deep learning algorithms.,"[600.0, 1186.0, 1091.0, 1227.0]",table_caption,0.9,"[""table prefix matched: Table 3. Performance evaluation of three traditional machine""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,15,table,
AlgorithmsTraining time (ms)Validation time (ms)
Decision tree0.9982821.591182
Random forest18.855333
AlgorithmsMean Absolute Error (MAE)Root Mean Square Error (RMSE)R-Squared
Decision tree0.329 $ \pm $ 0.0170.582 $ \pm $ 0,"[602.0, 1242.0, 1088.0, 1434.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +10,16,footer,"Adv. Sci. 2025, 12, 2412831","[93.0, 1487.0, 254.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,17,footer,2412831 (10 of 20),"[384.0, 1483.0, 527.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,18,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657.0, 1487.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,19,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1154.0, 31.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +11,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 346.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header_image,,"[931.0, 32.0, 1096.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +11,2,figure_title,a,"[104.0, 155.0, 124.0, 177.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,3,chart,,"[108.0, 166.0, 362.0, 423.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,4,figure_title,b,"[369.0, 152.0, 391.0, 176.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,5,chart,,"[368.0, 157.0, 603.0, 423.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,6,figure_title,C,"[611.0, 155.0, 631.0, 177.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,7,chart,,"[616.0, 165.0, 834.0, 427.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,8,chart,,"[848.0, 148.0, 1055.0, 426.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,9,figure_title,e,"[103.0, 430.0, 122.0, 451.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,10,chart,,"[109.0, 453.0, 415.0, 672.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,11,figure_title,f,"[426.0, 424.0, 442.0, 451.0]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,12,figure_title,g,"[749.0, 431.0, 769.0, 456.0]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,13,chart,,"[436.0, 438.0, 744.0, 679.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,14,figure_title,h,"[101.0, 669.0, 123.0, 697.0]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,15,chart,,"[783.0, 444.0, 1083.0, 681.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,16,chart,,"[114.0, 671.0, 424.0, 920.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,17,chart,,"[431.0, 679.0, 748.0, 923.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,18,chart,,"[774.0, 681.0, 1082.0, 922.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,19,figure_title,k,"[107.0, 934.0, 127.0, 960.0]",figure_inner_text,0.9,"[""panel label / figure inner text: k""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,20,image,,"[115.0, 937.0, 1090.0, 1173.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,21,figure_title,"Figure 6. Performance evaluation of traditional machine learning and deep learning models. a) Mean absolute error across models (n.s.: not significant, $ p < 0.0001 $). b) Mean squared error comparis","[95.0, 1181.0, 1099.0, 1316.0]",figure_caption,0.92,"[""figure_title label: Figure 6. Performance evaluation of traditional machine lear""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,22,footer,"Adv. Sci. 2025, 12, 2412831","[98.0, 1487.0, 260.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,23,number,2412831 (11 of 20),"[390.0, 1484.0, 533.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,24,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,25,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1153.0, 29.0, 1172.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +12,0,header_image,,"[92.0, 45.0, 339.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +12,1,header_image,,"[930.0, 34.0, 1089.0, 92.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +12,2,header,www.advancedscience.com,"[881.0, 97.0, 1090.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,3,figure_title,Table 4. Computation times of three traditional machine learning algorithms and two deep learning algorithms were measured using the dataset to evaluate their performance.,"[90.0, 149.0, 581.0, 206.0]",table_caption,0.9,"[""table prefix matched: Table 4. Computation times of three traditional machine lear""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +12,4,table,
AlgorithmsTraining time (ms)Testing time (ms)
Decision tree0.005 $ \pm $ 0.0020.005 $ \pm $ 0.001
Random forest
Activity levelFrequency (N = 993)Percentage
National team566
Competitive athlete16016
Knee pathologyN_{o}N_{c}N_{c} / $ \pm $ ,
ACL rupture89160.18
Old ACL injury63","[87.0, 542.0, 577.0, 771.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +5,9,vision_footnote," $ ^{a} $N $ _{o} $, number of patients with the different knee pathology in this material; N $ _{C} $, number of patients with current diagnosis with associated localized full-thickness cartilage les","[87.0, 785.0, 579.0, 848.0]",footnote,0.7,"[""vision_footnote label: $ ^{a} $N $ _{o} $, number of patients with the different kn""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,affiliation_marker,True,True +5,10,text,"osteochondritis dissecans lesions has demonstrated that failed surgical treatment will result in degenerative changes and problems, although initial results were quite promising. $ ^{3} $ Whether this","[85.0, 884.0, 580.0, 1061.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,11,paragraph_title,CONCLUSION,"[88.0, 1095.0, 227.0, 1118.0]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSION""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True +5,12,text,"This study shows that 6% of the patients admitted for arthroscopic procedures have a cartilage injury of ICRS grade 3 or 4 injury and size more than 2 cm². In total, about 11% of all knee arthroscopie","[85.0, 1137.0, 581.0, 1271.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,13,text,"ber of patients that will benefit from a cartilage repair pro- +cedure are so far unknown.","[622.0, 161.0, 1116.0, 205.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,14,paragraph_title,REFERENCES,"[626.0, 240.0, 755.0, 261.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +5,15,reference_content,"1. The cartilage standard evaluation form/knee. ICRS Newsletter, spring 1998.","[632.0, 279.0, 1116.0, 316.0]",reference_item,0.85,"[""reference content label: 1. The cartilage standard evaluation form/knee. ICRS Newslet""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,16,reference_content,"2. Alfredson H, Thorsen K, Lorentzon R: Treatment of tear of the anterior cruciate ligament combined with localised deep cartilage defects in the knee with ligament reconstruction and autologous perio","[633.0, 319.0, 1116.0, 392.0]",reference_item,0.85,"[""reference content label: 2. Alfredson H, Thorsen K, Lorentzon R: Treatment of tear of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,17,reference_content,"3. Angermann P, Riegels-Nielsen P, Pedersen H: Osteochondritis dissecans of the femoral condyle treated with periosteal transplantation: Poor outcome in 14 patients followed for 6–9 years. Acta Orthop","[633.0, 395.0, 1116.0, 469.0]",reference_item,0.85,"[""reference content label: 3. Angermann P, Riegels-Nielsen P, Pedersen H: Osteochondrit""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,18,reference_content,"4. Brittberg M, Lindahl A, Nilsson A, et al: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331: 889–895, 1994","[633.0, 471.0, 1115.0, 525.0]",reference_item,0.85,"[""reference content label: 4. Brittberg M, Lindahl A, Nilsson A, et al: Treatment of de""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,19,reference_content,"5. Curl WW, Krome J, Gordon ES, et al: Cartilage injuries: A review of 31,516 knee arthroscopies. Arthroscopy 13: 456–460, 1997","[633.0, 528.0, 1116.0, 564.0]",reference_item,0.85,"[""reference content label: 5. Curl WW, Krome J, Gordon ES, et al: Cartilage injuries: A""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,20,reference_content,"6. Hangody L, Kish G, Karpati Z, et al: Mosaicplasty for the treatment of articular cartilage defects: Application in clinical practice. Orthopedics 21: 751–756, 1998","[634.0, 566.0, 1116.0, 620.0]",reference_item,0.85,"[""reference content label: 6. Hangody L, Kish G, Karpati Z, et al: Mosaicplasty for the""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,21,reference_content,"7. Hjelle K, Austgulen O, Muri R, et al: Full thickness chondral defects: A prospective study of 1000 knee arthroscopies. Presented at International Cartilage Repair Society conference, Gothenburg, 20","[633.0, 623.0, 1116.0, 679.0]",reference_item,0.85,"[""reference content label: 7. Hjelle K, Austgulen O, Muri R, et al: Full thickness chon""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,22,reference_content,"8. Lewandrowski KU, Muller J, Schollmeier G: Concomitant meniscal and articular cartilage lesions in the femorotibial joint. Am J Sports Med 25: 486–494, 1997","[634.0, 680.0, 1116.0, 734.0]",reference_item,0.85,"[""reference content label: 8. Lewandrowski KU, Muller J, Schollmeier G: Concomitant men""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,23,reference_content,"9. Lorentzon R, Alfredson H, Hildingsson C: Treatment of deep cartilage defects of the patella with periosteal transplantation. Knee Surg Sports Traumatol Arthrosc 6: 202–208, 1998","[633.0, 737.0, 1116.0, 791.0]",reference_item,0.85,"[""reference content label: 9. Lorentzon R, Alfredson H, Hildingsson C: Treatment of dee""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,24,reference_content,"10. Mandelbaum BR, Browne JE, Fu F, et al: Articular cartilage lesions of the knee. Am J Sports Med 26: 853–861, 1998","[629.0, 794.0, 1116.0, 830.0]",reference_item,0.85,"[""reference content label: 10. Mandelbaum BR, Browne JE, Fu F, et al: Articular cartila""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,25,reference_content,"11. Messner K, Gillquist J: Cartilage repair: A critical review. Acta Orthop Scand 67: 523–529, 1996","[629.0, 833.0, 1115.0, 867.0]",reference_item,0.85,"[""reference content label: 11. Messner K, Gillquist J: Cartilage repair: A critical rev""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,26,reference_content,"12. Minas T, Peterson L: Advanced techniques in autologous chondrocyte transplantation. Clin Sports Med 18: 13–44, v–vi, 1999","[629.0, 871.0, 1115.0, 907.0]",reference_item,0.85,"[""reference content label: 12. Minas T, Peterson L: Advanced techniques in autologous c""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,27,reference_content,"13. Mont MA, Jones LC, Vogelstein BN, et al: Evidence of inappropriate application of autologous cartilage transplantation therapy in an uncontrolled environment. Am J Sports Med 27: 617–620, 1999","[629.0, 908.0, 1115.0, 963.0]",reference_item,0.85,"[""reference content label: 13. Mont MA, Jones LC, Vogelstein BN, et al: Evidence of ina""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,28,reference_content,"14. Murrell GA, Maddali S, Horovitz L, et al: The effects of time course after anterior cruciate ligament injury in correlation with meniscal and cartilage loss. Am J Sports Med 29: 9–14, 2001","[629.0, 965.0, 1115.0, 1019.0]",reference_item,0.85,"[""reference content label: 14. Murrell GA, Maddali S, Horovitz L, et al: The effects of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,29,reference_content,"15. Peterson L, Minas T, Brittberg M, et al: Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop May (374): 212–234, 2000","[629.0, 1023.0, 1116.0, 1076.0]",reference_item,0.85,"[""reference content label: 15. Peterson L, Minas T, Brittberg M, et al: Two- to 9-year ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,30,reference_content,"16. Steadman JR, Rodkey WG, Singleton SB, et al: Microfracture technique for full-thickness chondral defects: Technique and clinical results. Operative Techniques in Orthopaedics 7: 300–304, 1997","[629.0, 1079.0, 1116.0, 1134.0]",reference_item,0.85,"[""reference content label: 16. Steadman JR, Rodkey WG, Singleton SB, et al: Microfractu""]",reference_item,0.85,reference_zone,reference_like,heading_numbered,True,True +5,31,reference_content,"17. Stone KR, Walgenbach A: Surgical technique for articular cartilage transplantation to full thickness cartilage defects in the knee joint. Operative Techniques in Orthopaedics 7: 305–311, 1997","[628.0, 1136.0, 1115.0, 1191.0]",reference_item,0.85,"[""reference content label: 17. Stone KR, Walgenbach A: Surgical technique for articular""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,32,reference_content,"18. Zamber RW, Teitz CC, McGuire DA, et al: Articular cartilage lesions of the knee. Arthroscopy 5: 258–268, 1989","[628.0, 1193.0, 1116.0, 1229.0]",reference_item,0.85,"[""reference content label: 18. Zamber RW, Teitz CC, McGuire DA, et al: Articular cartil""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,33,reference_content,"19. Årøen A, Jones DG, Fu HF: Arthroscopic diagnosis and treatment of cartilage injuries. 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Activity levelFrequency (N = 993)Percentage
Electrolyte concentrations (mM)CytoplasmMatrixSinovial fluid
$ [Na^{+}] $40240-350140
$ [K^{+}] $,"[604.0, 1199.0, 1103.0, 1431.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,14,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,15,number,3,"[588.0, 1483.0, 603.0, 1500.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,16,footer,September 2018 | Volume 9 | Article 974,"[854.0, 1481.0, 1103.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,header,Maleckar et al.,"[86.0, 56.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,text,"chondrocyte can serve as a significant diffusion barrier, as demonstrated recently with the use of optical trap methods (McLane et al., 2013). It is also important to note that the literature now sugg","[83.0, 123.0, 584.0, 281.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"The articular joint receives only very limited blood supply. Accordingly, the synovial fluid must supply adult articular cartilage with the required (small amounts of) nutrients, as well as sufficient","[83.0, 283.0, 586.0, 697.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,MODEL DEVELOPMENT,"[84.0, 719.0, 370.0, 746.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: MODEL DEVELOPMENT""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +4,5,text,"We have developed a new, first generation mathematical model for the resting membrane potential, $ E_m $, of the chondrocyte, based partly on the experimental data obtained and described in section E","[82.0, 765.0, 584.0, 1201.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"The equation governing the transmembrane potential, V, of the chondrocyte is","[83.0, 1201.0, 581.0, 1247.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,display_formula," $$ \begin{align*}C_m\frac{dV}{dt}=&-(I_{K-DR}+I_{K-Ca}+I_{K-2p}+I_{K-ATP}+I_{Na,b}+I_{K,b}\\&+I_{Cl,b}+I_{NaK}+I_{NaCa}+I_{TRPV4})\tag{1}.\end{align*} $$ ","[90.0, 1268.0, 576.0, 1341.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,8,text,"where $ C_m $ is chondrocyte capacitance (8 pF). This equation includes all transport processes that are electrogenic i.e., generate net transmembrane current(s). + +The intracellular concentrations of","[82.0, 1360.0, 584.0, 1431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,"The intracellular concentrations of Na+, [Na+]i and K+, +[K+]i, are governed by two transport equations, namely,","[604.0, 122.0, 1100.0, 169.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,display_formula," $$ \frac{d[Na^{+}]_{i}}{dt}=\frac{-(I_{Na,b}+3I_{NaK}+3I_{NaCa}-I_{NaH})}{\nu o l_{i}F} $$ ","[670.0, 186.0, 1038.0, 236.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,11,formula_number,(2),"[1078.0, 201.0, 1102.0, 223.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +4,12,text,and,"[606.0, 253.0, 644.0, 275.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,short_fragment,False,True +4,13,display_formula," $$ \frac{d[K^{+}]_{i}}{dt}=\frac{-(I_{K,b}-2I_{NaK}+I_{K-DR}+I_{K-2p}+I_{K-Ca}+I_{K-ATP})}{\nu o l_{i}F} $$ ","[606.0, 288.0, 1103.0, 338.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,14,formula_number,(3),"[1077.0, 337.0, 1101.0, 358.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +4,15,text,"where $ vol_i $ is the internal volume of the chondrocyte (calculated to be 0.005884 mL), and $ F $ is the Faraday constant, 96,485 C/mol. Note that Equation (1) does not include $ I_{NaH} $, since","[602.0, 357.0, 1106.0, 747.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,16,text,"Intracellular Ca²⁺ concentration, [Ca²⁺]ᵢ, also changes with time, due to transmembrane transport of Ca²⁺ by the Na⁺-Ca²⁺ exchanger and ATP-dependent Ca²⁺ pump, and intracellular calmodulin binding, a","[603.0, 747.0, 1109.0, 840.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,17,display_formula," $$ \frac{d\left[Ca^{2+}\right]_{i}}{dt}=\frac{\left(I_{NaCa}-I_{Ca,ATP}\right)}{\nu o l_{i}F}-0.045\frac{d\mathbf{O}_{c}}{dt} $$ ","[675.0, 858.0, 1034.0, 911.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,18,formula_number,(4),"[1078.0, 876.0, 1102.0, 898.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +4,19,text,where $ O_c $ is the fraction of intracellular calmodulin bound to $ Ca^{2+} $ (see Equation 39).,"[605.0, 928.0, 1104.0, 973.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,20,text,"Differential equations (1–4) and those for $ I_{K,Ca} $ and calmodulin buffering were solved numerically. All data simulations and processing was performed off-line using both noncommercial and comme","[603.0, 973.0, 1107.0, 1159.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,21,paragraph_title,"RESULTS Ion-Selective Transmembrane Currents +Potassium Currents","[604.0, 1180.0, 1061.0, 1267.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: RESULTS Ion-Selective Transmembrane Currents\nPotassium Curre""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,22,footer,,"[604.0, 1217.0, 1061.0, 1267.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,23,text,"We have identified and partially characterized three different $ K^{+} $ currents in mammalian chondrocytes. In principle, each of these can contribute to the resting membrane potential, $ E_{m} $, ","[606.0, 1269.0, 1106.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,24,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,25,number,4,"[588.0, 1483.0, 602.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,26,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1481.0, 1104.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,header,Maleckar et al.,"[86.0, 56.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,Chondrocyte K⁺ Currents Modulate E_m,"[858.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,image,,"[246.0, 130.0, 937.0, 626.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,"FIGURE 1 | Schematic illustration of the main ion selective channels, ion exchange proteins, and ATP-dependent ion pumps that are known to be expressed in human chondrocytes. This information forms th","[93.0, 649.0, 1092.0, 785.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 1 | Schematic illustration of the main ion selective ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +5,4,text,"K⁺ channels, I_K-2p; and (iii) a large conductance voltage and Ca²⁺-activated K⁺ current, I_K-Ca, have been studied in some detail in our laboratory (Wilson et al., 2004; Clark et al., 2010, 2011, res","[84.0, 832.0, 584.0, 1038.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,"A typical pattern of K⁺ currents from our patch clamp recordings using single isolated human articular chondrocytes (denoted HAC) is illustrated in Figure 2A. This chondrocyte first held at −80 mV, an","[83.0, 1040.0, 584.0, 1314.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,"Figure 2B consists of an averaged isochronal current-voltage (I–V) relationship based on data obtained from 13 human chondrocytes, each studied after 1 day in cell culture. The magnitude of these $ K","[84.0, 1314.0, 584.0, 1431.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 2B consists of an averaged isochronal current-voltage""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +5,7,text,"in cell size. Note that this I–V relationship is approximately +linear at membrane potentials negative to about −50 mV but +becomes non-linear at more depolarized voltages. The solid red +trace shows the","[603.0, 833.0, 1106.0, 1109.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,paragraph_title,Delayed rectifier $ K^{+} $ current: $ I_{K-DR} $,"[605.0, 1131.0, 896.0, 1154.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Delayed rectifier $ K^{+} $ current: $ I_{K-DR} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +5,9,text,"A conventional time- and voltage-dependent delayed rectifier $ K^{+} $ current has been identified in mouse, canine, rabbit, and human articular chondrocytes under primary culture conditions (Wilson ","[605.0, 1153.0, 1105.0, 1384.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,The presence of this small time- and voltage-dependent current in these human chondrocyte (HAC) preparations was,"[604.0, 1384.0, 1107.0, 1431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,12,number,5,"[588.0, 1483.0, 603.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,13,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1482.0, 1103.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,0,header,Maleckar et al.,"[86.0, 56.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,Chondrocyte K⁺ Currents Modulate E_m,"[858.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,2,chart,,"[217.0, 133.0, 615.0, 457.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,3,figure_title,B,"[636.0, 137.0, 652.0, 156.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,4,chart,,"[633.0, 154.0, 971.0, 484.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,figure_title,"FIGURE 2 | Family of K⁺ currents recorded from an isolated human chondrocyte maintained in primary 2D culture conditions. (A) These currents were recorded from a chondrocyte that was held at −80mV, an","[94.0, 509.0, 1093.0, 608.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 2 | Family of K\u207a currents recorded from an isolated h""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +6,6,text,revealed more clearly when the linear leak and capacity currents were removed from the raw current records (see Methods section). An example of current records from one HAC preparation in which these ,"[81.0, 658.0, 585.0, 1391.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,display_formula, $$ I_{K-D R}=g_{K-D R}\alpha_{K D r}(\mathrm{V}-\mathrm{E_{K}}) $$ ,"[208.0, 1407.0, 460.0, 1431.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +6,8,formula_number,(5),"[557.0, 1408.0, 581.0, 1429.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,9,text,where,"[606.0, 657.0, 661.0, 678.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,short_fragment,False,True +6,10,text,"gK–DR is the maximal $ I_{K–DR} $ conductance, namely 0.0289 nS/pF from Figure 3B, and","[603.0, 681.0, 1103.0, 726.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,text," $ \alpha_{KDr} $ is a voltage-dependent activation factor, given by the expression","[604.0, 727.0, 1105.0, 773.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,12,display_formula, $$ \alpha_{K D r}=\frac{1.0}{\left(1.0+e^{\frac{-(V+26.7)}{4.1}}\right)} $$ ,"[751.0, 787.0, 955.0, 841.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +6,13,formula_number,(6),"[1078.0, 800.0, 1102.0, 821.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,14,text,"Note that the extracellular potassium concentration, $ [K^+]_0 $, was initially set to 5.4 mM under “typical” physiological conditions. In fact, however, $ [K^+]_0 $ is likely to be in the 5–15 mM r","[603.0, 857.0, 1106.0, 1022.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,15,paragraph_title, $ Ca^{2+} $-activated $ K^{+} $ current: $ I_{K-Ca} $,"[606.0, 1037.0, 890.0, 1063.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: $ Ca^{2+} $-activated $ K^{+} $ current: $ I_{K-Ca} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +6,16,text,The prominent fluctuations in outward current traces recorded from all human chondrocytes at strongly depolarized membrane potentials suggested the expression of this “large” variant of Ca²⁺-activated,"[604.0, 1063.0, 1106.0, 1383.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,17,text,"To more clearly reveal the functionally important properties of this BK current, additional experiments were carried out","[604.0, 1385.0, 1106.0, 1431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,18,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 352.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,19,number,6,"[588.0, 1483.0, 602.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,20,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1482.0, 1103.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,header,Maleckar et al.,"[86.0, 56.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,chart,,"[178.0, 134.0, 592.0, 523.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,3,figure_title,B,"[606.0, 138.0, 621.0, 156.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,4,chart,,"[602.0, 144.0, 1009.0, 533.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,5,figure_title,"FIGURE 3 | Delayed rectifier K⁺ currents, I_K–DR, in a human chondrocyte. (A) Examples of I_K–DR activated by voltage-clamp steps from holding potential of −80 mV to membrane potentials of −40, −30, −","[95.0, 561.0, 1094.0, 641.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 3 | Delayed rectifier K\u207a currents, I_K\u2013DR, in a human""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +7,6,text,"using a pipette solution containing 3 mM Ca²⁺ and 10 mM EGTA, which yielded a nominal free Ca²⁺ concentration of ~175 nM. Data from these experiments are summarized in Figure 4. Currents from two grou","[83.0, 696.0, 587.0, 1202.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"It is well-known that the molecular properties and biophysical characteristics of the extensive Ca²⁺ activated K⁺ channel family can be used to divide them into three sub-groups (Berkefeld et al., 201","[83.0, 1202.0, 585.0, 1410.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"strongly suggest the presence of the variant of Ca2+ activated K+ +channels known as the large conductance subtype, BK. The major +properties of this current (cf. Horrigan and Aldrich, 2002) have +been i","[603.0, 695.0, 1107.0, 809.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"The mathematical description for this $ Ca^{2+} $-activated $ K^{+} $current is a 10-state kinetic Markov-type model, including four calcium-binding steps, with all the voltage dependence assigned t","[604.0, 809.0, 1107.0, 926.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,display_formula, $$ \frac{d\mathbf{C}_{O}}{dt}=\beta_{O}\mathbf{O}_{o}-\alpha_{O}\mathbf{C}_{o}+K_{c}\mathbf{C}_{1}-4Ca\mathbf{C}_{o} $$ ,"[607.0, 938.0, 932.0, 986.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,11,formula_number,(7),"[1078.0, 952.0, 1102.0, 972.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,12,display_formula, $$ \frac{d\mathbf{C}_{1}}{dt}=\beta_{1}\mathbf{O}_{1}-\alpha_{1}\mathbf{C}_{1}-K_{c}\mathbf{C}_{1}+4Ca\mathbf{C}_{o}-3Ca\mathbf{C}_{1}+2K_{c}\mathbf{C}_{2} $$ ,"[610.0, 987.0, 1073.0, 1030.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,13,formula_number,(8),"[1079.0, 999.0, 1102.0, 1019.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,14,display_formula, $$ \frac{d\mathbf{C}_{2}}{dt}=\beta_{2}\mathbf{O}_{2}-\alpha_{2}\mathbf{C}_{2}-2K_{c}\mathbf{C}_{2}+3Ca\mathbf{C}_{1}-2Ca\mathbf{C}_{2}+3K_{c}\mathbf{C}_{3} $$ ,"[611.0, 1033.0, 1081.0, 1080.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,15,formula_number,(9),"[1078.0, 1079.0, 1102.0, 1100.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,16,display_formula, $$ \frac{d\mathbf{C}_{3}}{dt}=\beta_{3}\mathbf{O}_{3}-\alpha_{3}\mathbf{C}_{3}-3K_{c}\mathbf{C}_{3}+2Ca\mathbf{C}_{2}-Ca\mathbf{C}_{3}+4K_{c}\mathbf{C}_{4} $$ ,"[611.0, 1102.0, 1073.0, 1147.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,17,formula_number,(10),"[1069.0, 1149.0, 1101.0, 1170.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,18,display_formula, $$ \frac{d\mathbf{C}_{4}}{dt}=\beta_{4}\mathbf{O}_{4}-\alpha_{4}\mathbf{C}_{4}-4K_{c}\mathbf{C}_{4}+Ca\mathbf{C}_{3} $$ ,"[611.0, 1169.0, 927.0, 1218.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,19,formula_number,(11),"[1069.0, 1185.0, 1101.0, 1206.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,20,display_formula, $$ \frac{d\mathbf{O}_{0}}{dt}=-\beta_{0}\mathbf{O}_{0}+\alpha_{0}\mathbf{C}_{0}+K_{0}\mathbf{O}_{1}-4Ca\mathbf{O}_{0} $$ ,"[610.0, 1219.0, 945.0, 1264.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,21,formula_number,(12),"[1069.0, 1232.0, 1102.0, 1253.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,22,display_formula, $$ \frac{d\mathbf{O}_{1}}{dt}=-\beta_{1}\mathbf{O}_{1}+\alpha_{1}\mathbf{C}_{1}-K_{o}\mathbf{O}_{1}+4Ca\mathbf{O}_{o}-3Ca\mathbf{O}_{1}+2K_{o}\mathbf{O}_{2} $$ ,"[608.0, 1265.0, 1095.0, 1312.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,23,formula_number,(13),"[1069.0, 1314.0, 1102.0, 1335.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,24,display_formula, $$ \frac{d\mathbf{O}_{1}}{dt}=-\beta_{2}\mathbf{O}_{2}+\alpha_{2}\mathbf{C}_{2}-2K_{o}\mathbf{O}_{2}+3Ca\mathbf{O}_{1}-2Ca\mathbf{O}_{2}+2K_{o}\mathbf{O}_{3} $$ ,"[608.0, 1335.0, 1104.0, 1384.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,25,formula_number,(14),"[1069.0, 1386.0, 1102.0, 1407.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,26,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,27,number,7,"[588.0, 1483.0, 602.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,28,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1481.0, 1104.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,0,header,Maleckar et al.,"[86.0, 57.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858.0, 56.0, 1103.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,2,figure_title,A,"[225.0, 136.0, 242.0, 155.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,3,image,,"[227.0, 135.0, 501.0, 382.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,4,chart,,"[533.0, 136.0, 955.0, 433.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,5,figure_title,B,"[226.0, 400.0, 241.0, 418.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,6,chart,,"[226.0, 407.0, 524.0, 622.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,7,figure_title,D,"[585.0, 446.0, 603.0, 464.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,8,chart,,"[581.0, 457.0, 965.0, 741.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,"FIGURE 4 | Effect of changes in intracellular Ca²⁺, [Ca²⁺], concentration on K⁺ currents in human articular chondrocytes. (A) ×example of currents from a hN₂ with ""low"" internal [Ca²⁺], (0 [Ca²⁺], 10 ","[92.0, 767.0, 1087.0, 885.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 4 | Effect of changes in intracellular Ca\u00b2\u207a, [Ca\u00b2\u207a], ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +8,10,display_formula, $$ \frac{d\mathbf{O}_{3}}{dt}=-\beta_{3}\mathbf{O}_{3}+\alpha_{3}\mathbf{C}_{3}-3K_{o}\mathbf{O}_{3}+2Ca\mathbf{O}_{2}-Ca\mathbf{O}_{3}+4K_{o}\mathbf{O}_{4} $$ ,"[88.0, 929.0, 574.0, 975.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,11,formula_number,(15),"[548.0, 978.0, 580.0, 998.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,12,display_formula, $$ \frac{d\mathbf{O}_{4}}{d t}=-\beta_{4}\mathbf{O}_{4}+\alpha_{4}\mathbf{C}_{4}-4K_{o}\mathbf{O}_{4}+C a\mathbf{O}_{3} $$ ,"[88.0, 1000.0, 425.0, 1048.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,13,formula_number,(16),"[549.0, 1014.0, 580.0, 1033.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,14,text,"where $ C_{n=0,1,2,3,4} $ and $ O_{n=0,1,2,3,4} $ are closed and open states 1 through 4, respectively, with the total open probability corresponding to the sum of the open states, $ O $; $ \alpha","[83.0, 1067.0, 584.0, 1250.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,display_formula, $$ \alpha_{n}=A_{n}e^{\frac{z_{CO}VF}{RT}} $$ ,"[257.0, 1269.0, 392.0, 1305.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,16,formula_number,(17),"[548.0, 1279.0, 580.0, 1300.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,17,display_formula, $$ \beta_{n}=B_{n}e^{\frac{z_{OC}VF}{RT}} $$ ,"[259.0, 1304.0, 392.0, 1339.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,18,formula_number,(18),"[548.0, 1314.0, 580.0, 1335.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,19,display_formula," $$ A_{0}=0.659,A_{1}=3.955,A_{2}=25.05,A_{3}=129.2,A_{4}=261.1; $$ ","[106.0, 1361.0, 578.0, 1385.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,20,display_formula," $$ B_{0}=2651.7,B_{1}=1767.8,B_{2}=1244.0,B_{3}=713.0,B_{4}=160.0; $$ ","[108.0, 1384.0, 583.0, 1408.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,21,display_formula," $$ z_{CO}=0.718,z_{OC}=0.646,K_{c}=13.5,K_{O}=1.5, $$ ","[108.0, 1410.0, 567.0, 1431.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,22,text,"and the Ca²⁺ on-rates per site are 10⁹ M⁻¹s⁻¹, Ca²⁺ off-rates from Cₙ per binding site are 10⁹ Kₑ (13,500 s⁻¹) and Ca²⁺ off-rates from Oₙ per binding site are 10⁹ Kₒ (1,500 s⁻¹), and R is the universa","[604.0, 931.0, 1105.0, 1049.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,23,text, $ I_{K-Ca} $ is then defined by:,"[629.0, 1050.0, 825.0, 1072.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,24,display_formula, $$ I_{K-Ca}=g_{K-Ca}\mathbf{O}(V-E_{K}) $$ ,"[744.0, 1102.0, 965.0, 1126.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,25,formula_number,(19),"[1069.0, 1102.0, 1101.0, 1123.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,26,text,"where $ g_{K-Ca} $ is the maximal conductance of the channel, equal to 2.50 nS/pF, O is the total open probability as given above, V is the transmembrane potential, and $ E_{K} $ is the Nernst poten","[604.0, 1155.0, 1105.0, 1245.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,27,text,We have used this mathematical formalism to compute I-V relationships for BK currents that can be assumed to have been recorded from isolated human chondrocytes under conditions in which the compositi,"[603.0, 1247.0, 1106.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,28,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1483.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,29,number,8,"[588.0, 1483.0, 602.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,30,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1482.0, 1103.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,header,Maleckar et al.,"[86.0, 57.0, 180.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,2,text,"depolarized membrane potentials, as shown by the computations summarized in Figure 4D.","[83.0, 123.0, 583.0, 168.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,Further information regarding the functional properties of this BK channel-mediated current was obtained using conventional pharmacological approaches. As shown in Figure 5 this $ K^{+} $ current can,"[81.0, 169.0, 584.0, 353.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"Although, $ I_{K-Ca} $ is a major outward current in human chondrocytes, it apparently does not contribute substantially to the resting potential under our conditions. This is because of the followin","[82.0, 352.0, 586.0, 606.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,paragraph_title,2-Pore $ K^{+} $ current: $ I_{K-2p} $,"[606.0, 122.0, 819.0, 146.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2-Pore $ K^{+} $ current: $ I_{K-2p} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +9,6,text,"Our previous work (Clark et al., 2011) defined recording conditions under which a K⁺ current generated by the TASK family of two-pore K⁺ channels could be identified consistently in single chondrocyte","[602.0, 144.0, 1106.0, 395.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,text,"We have recorded this $ K^{+} $ current under high $ [K^{+}]_{0} $ conditions, to ensure that the current changes are relatively large, so that their biophysical properties can be resolved. However,","[603.0, 397.0, 1107.0, 606.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,figure_title,A,"[168.0, 662.0, 186.0, 682.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,image,,"[166.0, 661.0, 531.0, 800.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,10,figure_title,B,"[169.0, 825.0, 186.0, 843.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,11,image,,"[169.0, 821.0, 529.0, 920.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,12,chart,,"[554.0, 660.0, 1023.0, 975.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,13,figure_title,C,"[168.0, 978.0, 187.0, 998.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,14,chart,,"[165.0, 987.0, 550.0, 1288.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,15,figure_title,E,"[583.0, 986.0, 601.0, 1006.0]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,16,chart,,"[577.0, 1000.0, 1010.0, 1299.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,17,figure_title,FIGURE 5 | Block of $ I_{K-Ca} $ in human chondrocyte by TEA. (A) Control currents. The voltage-clamp protocol consisted of 500 ms steps from h.p. -80 to +100 mV. Linear leak and capacitive currents ,"[90.0, 1319.0, 1095.0, 1418.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 5 | Block of $ I_{K-Ca} $ in human chondrocyte by TE""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +9,18,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,19,number,9,"[588.0, 1483.0, 602.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,20,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1481.0, 1104.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,0,header,Maleckar et al.,"[86.0, 57.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,2,text,"square root of the extracellular concentration of the permeant ion. Accordingly, $ I_{K-2p} $ is described by the classical Goldman-Hodgkin-Katz equation for a single ion species, with a square-root ","[83.0, 123.0, 584.0, 216.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,display_formula, $$ I_{K-2p}=\frac{P_{k}z^{2}V F^{2}}{R T}\frac{\left(\left[K^{+}\right]_{i}-\left[K^{+}\right]_{o}e^{\frac{-z V F}{R T}}\right)}{\left(1-e^{\frac{-z V F}{R T}}\right)} $$ ,"[166.0, 237.0, 499.0, 313.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,4,formula_number,(20),"[547.0, 264.0, 578.0, 287.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,5,text,"where $ P_K $ is a $ [K^+] $-dependent scaling factor that describes the permeability (conductance) for this $ K^+ $ current, namely $ 3.1 \times 10^{-6} $ $ \sqrt{([K^+]_i / [K^+]_o)} $, and $ ","[82.0, 337.0, 582.0, 408.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"The I–V relationship in Figure 6A shows that our primary data (Wilson et al., 2004) recorded in isotonic $ [K^+] $ ( $ \sim $145 mM), has the expected reversal potential (of 0 mV). The I–V relationsh","[83.0, 408.0, 584.0, 570.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,chart,,"[109.0, 627.0, 566.0, 873.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,8,figure_title,Voltage (mV),"[323.0, 880.0, 421.0, 904.0]",figure_caption_candidate,0.85,"[""figure_title label: Voltage (mV)""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +10,9,figure_title,B,"[113.0, 922.0, 130.0, 942.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,10,chart,,"[127.0, 919.0, 560.0, 1180.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,11,figure_title,FIGURE 6 | Analysis of the ion transfer function (I–V relationship) for a 2-pore K⁺ current in human chondrocytes. (A) Raw experimental data plotted as an I–V curve together with a superimposed I–V re,"[91.0, 1206.0, 568.0, 1419.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 6 | Analysis of the ion transfer function (I\u2013V relati""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +10,12,text,"As illustrated in Table 1, the extracellular milieu of the chondrocyte is somewhat unusual, since it has been reported to have a $ [K^+]_{o} $ level of $ \sim $7–12 mM. Accordingly, a I–V curve for ","[603.0, 122.0, 1107.0, 377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,13,paragraph_title,ATP-sensitive $ K^{+} $ current: $ I_{K-ATP} $,"[605.0, 402.0, 888.0, 425.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: ATP-sensitive $ K^{+} $ current: $ I_{K-ATP} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +10,14,text,"An ATP-sensitive K⁺ current I_K-ATP has been identified in chondrocytes that were isolated from the knee joint of a number of different mammalian species (Barrett-Jolley et al., 2010; Mobasheri et al.","[601.0, 425.0, 1107.0, 864.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,15,display_formula," $$ I_{K-,A T P}=\sigma g_{o}p_{o}f_{A T P}(\mathbf{V}-\mathbf{E_{K}}) $$ ","[722.0, 891.0, 972.0, 916.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,16,formula_number,(21),"[1068.0, 892.0, 1102.0, 914.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,17,text,"where $ \sigma = 0.6 $ is the channel density, $ g_o $ is the unitary channel conductance, $ p_o = 0.91 $ is the maximum open channel probability, and $ f_{ATP} $ is the fraction of activated chan","[603.0, 944.0, 1106.0, 1037.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,18,display_formula, $$ f_{ATP}=\frac{1.0}{1.0+\left[\frac{ATP_{i}}{K_{m}}\right]^{H}} $$ ,"[739.0, 1062.0, 926.0, 1129.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,19,formula_number,(22),"[1069.0, 1075.0, 1102.0, 1096.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,20,formula_number,(23),"[1069.0, 1136.0, 1101.0, 1157.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,21,display_formula, $$ H=1.3+0.74e^{-H_{K_{A T P}}A D P_{i}} $$ ,"[758.0, 1132.0, 981.0, 1159.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,22,display_formula," $$ K_{m}=35.8+17.9ADP_{i}^{K_{m,ATP}} $$ ","[748.0, 1161.0, 982.0, 1188.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,23,formula_number,(24),"[1069.0, 1165.0, 1101.0, 1186.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,24,display_formula, $$ \mathrm{ADP_{i}~=~C_{A}-ATP_{i}} $$ ,"[727.0, 1193.0, 905.0, 1218.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,25,formula_number,(25),"[1069.0, 1194.0, 1101.0, 1215.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,26,text,"where $ C_A = 8 \, mM $ is the total concentration of adenine nucleotides, $ ADP_i $ and $ ATP_i $ are the intracellular concentrations of adenosine diphosphate, (ADP) and adenosine triphosphate, (","[603.0, 1246.0, 1104.0, 1339.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,27,text,"Note that this ATP-sensitive K⁺ current is not utilized in our initial description of the ionic basis for the HAC resting potential. That is, its channel density, σ, has been set to zero in our initia","[603.0, 1339.0, 1105.0, 1431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,28,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,29,number,10,"[586.0, 1483.0, 606.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,30,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1481.0, 1103.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,header,Maleckar et al.,"[86.0, 57.0, 180.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1104.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,2,paragraph_title,Time-Independent or Background Ionic Currents,"[84.0, 122.0, 540.0, 145.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Time-Independent or Background Ionic Currents""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +11,3,text,"Three distinct time-independent background (or leakage) conductances corresponding to “resting” Na⁺, K⁺, and Cl⁻ fluxes, have been included in this model. Simple mathematical descriptors for each cond","[84.0, 147.0, 583.0, 259.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"The background (inward) $ Na^{+} $ and (outward) $ K^{+} $ currents, are described by.","[84.0, 259.0, 583.0, 307.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,display_formula," $$ I_{Na,b}\;=\;G_{Na,b}(\mathrm{V}-\mathrm{E_{Na}}) $$ ","[226.0, 328.0, 426.0, 352.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,6,formula_number,(26),"[547.0, 329.0, 580.0, 350.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,7,display_formula," $$ I_{K,b}=G_{K,b}(\mathbf{V}-\mathbf{E_{K}}) $$ ","[245.0, 357.0, 426.0, 381.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,8,formula_number,(27),"[548.0, 358.0, 580.0, 379.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,9,text,"where $ G_{Na,b} = 0.1 $ nS/pF is the maximum conductance for the background sodium channel, and $ G_{K,b} = 0.07 $ nS/pF is the maximum conductance for the background potassium channel. $ [Na^+]_o","[82.0, 401.0, 584.0, 700.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,text,"In mammalian chondrocytes from a number of different species, a significant background $ Cl^{-} $conductance has also been identified (cf. Tsuga et al., 2002; Barrett-Jolley et al., 2010; Funabashi e","[83.0, 701.0, 584.0, 840.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,display_formula," $$ I_{Cl,b}\;=\;{\bf G}_{Cl,b}(V-E_{Cl}) $$ ","[241.0, 860.0, 428.0, 885.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,12,formula_number,(28),"[547.0, 861.0, 581.0, 882.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,13,text,"where $ G_{Cl,b} = 0.05 $ pS/pF is the maximum conductance for the background $ Cl^{-} $ channel, and where the reversal potential, is -65 mV. The I-V relationships for these three background curren","[82.0, 904.0, 584.0, 998.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,14,paragraph_title,Ion Pump and Exchanger Currents Electrogenic Na $ ^{+} $/K $ ^{+} $ pump: I $ _{NaK} $,"[84.0, 1012.0, 410.0, 1061.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Ion Pump and Exchanger Currents Electrogenic Na $ ^{+} $/K $""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +11,15,footer,,"[85.0, 1038.0, 365.0, 1061.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +11,16,text,Active (ATP requiring) extrusion of Na⁺ from chondrocytes is assumed to be achieved by the combined expression level and turnover rate of a conventional electrogenic Na⁺/K⁺ pump. Mobasheri et al. (199,"[84.0, 1061.0, 583.0, 1225.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,17,display_formula, $$ \begin{aligned}I_{NaK}&=\overline{I}_{NaK}\left(\frac{\left[K^{+}\right]_{o}}{\left[K^{+}\right]_{o}+k_{NaK_{K}}}\right)\left(\frac{\left[Na^{+}\right]_{i}^{1.5}}{\left[Na^{+}\right]_{i}^{1.5}+k_{,"[114.0, 1241.0, 548.0, 1359.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,18,formula_number,(29),"[547.0, 1326.0, 581.0, 1347.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,19,text,where $\bar{I}_{NaK}$ is the maximal current density $1.58\ \mathrm{pA/pF}\ \left[\mathrm{K}^{+}\right]_{0}$ is the extracellular potassium concentration. It has been initially set to $140\ \mathrm{mM,"[82.0, 1382.0, 582.0, 1431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,20,text,"set to 140 mM for “typical” values; Table 1), [Na+]i is the +intracellular sodium concentration, as defined previously, and +given by equation (2), kNaK,K is the half-maximum K+ binding +concentration, an","[604.0, 122.0, 1105.0, 235.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,21,text,"This Na⁺/K⁺ pump activity (the product of expression density and turnover rate) generates a small outward electrogenic current. In this simplified model (cf. Trujillo et al., 1999) this Na⁺/K⁺ pump ma","[603.0, 236.0, 1106.0, 378.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,22,display_formula, $$ Na^{+}/Ca^{2}+Exchanger:I_{NaCa} $$ ,"[606.0, 390.0, 847.0, 415.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,23,text,"The activity of the Na⁺/Ca²⁺ exchanger plays a key role in Ca²⁺ homeostasis in articular chondrocytes (Sánchez et al., 2006) as it does in most other cell types. We have modeled this electrogenic exch","[603.0, 413.0, 1105.0, 532.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,24,chart,,"[615.0, 588.0, 1092.0, 869.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,25,vision_footnote,"Na_i = 8.5mM, Na_o = 130mM, Ca_i = 5e-5mM, Ca_o = 2mM","[649.0, 923.0, 1094.0, 943.0]",footnote,0.7,"[""vision_footnote label: Na_i = 8.5mM, Na_o = 130mM, Ca_i = 5e-5mM, Ca_o = 2mM""]",footnote,0.7,body_zone,unknown_like,none,True,True +11,26,figure_title,B,"[624.0, 948.0, 643.0, 966.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,27,image,,"[627.0, 959.0, 1076.0, 1223.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,28,figure_title,"FIGURE 7 | Illustrations of the relative sizes of net currents produced by (A) the Na⁺/K⁺ pump, and (B) the Na⁺/Ca²⁺ exchanger in a human chondrocyte. The three superimposed I–V curves for the Na⁺/K⁺ ","[613.0, 1242.0, 1091.0, 1418.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 7 | Illustrations of the relative sizes of net curren""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +11,29,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1502.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,30,number,11,"[585.0, 1483.0, 605.0, 1500.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,31,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1482.0, 1104.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,0,header,Maleckar et al.,"[86.0, 57.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,2,text,"properties (ion transfer characteristics, dependence on $ [Na^{+}]_{i} $ and $ [Ca^{2+}]_{i} $ have been validated previously (Nygren et al., 1998):","[83.0, 122.0, 582.0, 170.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,display_formula, $$ I_{NaCa}=k_{NaCa}\frac{\left[Na^{+}\right]_{i}^{3}\left[Ca^{2+}\right]_{o}e^{\frac{\gamma VF}{RT}}-\left[Na^{+}\right]_{o}^{3}\left[Ca^{2+}\right]_{i}e^{\frac{(\gamma-1.0)VF}{RT}}}{1.0+d_{NaCa}\le,"[88.0, 193.0, 575.0, 262.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,4,formula_number,(30),"[548.0, 259.0, 581.0, 280.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,5,text,"Where $ k_{NaCa} $ is a scaling factor for this current, set to 0.0374842 pA/(mmol/L) $ ^4 $, $ \gamma $ is the position of the energy barrier that modulates the voltage dependence of $ I_{NaCa} $,","[83.0, 279.0, 584.0, 508.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,text,"This electrogenic ion exchange mechanism has been scaled based on a baseline or resting $ [\mathrm{Na}^{+}]_{\mathrm{i}} $ of 12 mM, and $ [\mathrm{Ca}^{2+}]_{\mathrm{i}} $ of 3 x 10 $ ^{-8} $ M (se","[83.0, 511.0, 580.0, 605.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,paragraph_title, $ Na^{+}/H^{+} $ exchanger: $ I_{NaH} $,"[86.0, 623.0, 296.0, 648.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: $ Na^{+}/H^{+} $ exchanger: $ I_{NaH} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +12,8,text,"Chondrocytes express a Na⁺/H⁺ antiporter (Trujillo et al., 1999; Barrett-Jolley et al., 2010) that contributes importantly to pH regulation. By analogy with its role in many other cells and tissues, t","[84.0, 647.0, 583.0, 899.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,We have used the equations originally developed by Crampin and Smith (2006) to model this electroneutral antiporter:,"[83.0, 900.0, 583.0, 946.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,10,display_formula, $$ I_{NaH}=N_{NaH}I_{NaH_{mod}}I_{NaH_{exch}} $$ ,"[230.0, 973.0, 458.0, 1000.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,11,formula_number,(31),"[548.0, 974.0, 580.0, 995.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,12,display_formula, $$ I_{NaHmod}=\frac{1}{1+(K_{i}^{n_{H}}/\left[H^{+}\right]_{i}^{n_{H}}} $$ ,"[205.0, 1013.0, 453.0, 1064.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,13,formula_number,(32),"[548.0, 1023.0, 580.0, 1044.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,14,display_formula, $$ I_{NaH_{exch}}=\frac{t_{1}t_{2}-t_{3}t_{4}}{t_{1}+t_{2}+t_{3}+t_{4}} $$ ,"[210.0, 1076.0, 434.0, 1126.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,15,formula_number,(33),"[548.0, 1088.0, 580.0, 1109.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,16,display_formula, $$ t_{1}=\frac{k_{1}^{+}\left[Na^{+}\right]_{o}/K_{Na}^{o}}{1+\frac{\left[Na^{+}\right]_{o}}{K_{Na}^{o}}+\frac{\left[H^{+}\right]_{o}}{K_{H}^{o}}} $$ ,"[252.0, 1144.0, 460.0, 1219.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,17,formula_number,(34),"[548.0, 1165.0, 580.0, 1186.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,18,display_formula, $$ t_{2}=\frac{k_{2}^{+}\left[H^{+}\right]_{i}/K_{H}^{i}}{1+\frac{\left[Na^{+}\right]_{i}}{K_{Na}^{i}}+\frac{\left[H^{+}\right]_{i}}{K_{H}^{i}}} $$ ,"[252.0, 1240.0, 456.0, 1316.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,19,formula_number,(35),"[548.0, 1261.0, 580.0, 1282.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,20,display_formula, $$ t_{3}=\frac{k_{1}^{-}\left[Na^{+}\right]_{i}/K_{Na}^{i}}{1+\frac{\left[Na^{+}\right]_{i}}{K_{Na}^{i}}+\frac{\left[H^{+}\right]_{i}}{K_{H}^{i}}} $$ ,"[252.0, 1339.0, 455.0, 1412.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,21,formula_number,(36),"[547.0, 1359.0, 580.0, 1380.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,22,display_formula, $$ t_{4}=\frac{k_{2}^{-}\left[H^{+}\right]_{o}/K_{H}^{o}}{1+\frac{\left[Na^{+}\right]_{o}}{K_{Na}^{o}}+\frac{\left[H^{+}\right]_{o}}{K_{H}^{o}}} $$ ,"[772.0, 116.0, 980.0, 188.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,23,formula_number,(37),"[1069.0, 134.0, 1102.0, 157.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,24,text,"where, $ N_{NaH} = 4899 $, $ k_1^+ $ = 10.5, $ k_1^- $ = 0.201, $ k_2^+ $ = 15.8, $ k_2^- $ = 183, $ k_H^{i} $ = 3.07e-5, $ k_H^{i} $ = 4.8e-7, $ k_Na^+ $ = 16.2, $ k_Na^- $ = 195, $ k_H^+ $","[606.0, 231.0, 1105.0, 442.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,25,paragraph_title,"Intracellular $ [Ca^{2+}]_{i} $ Homeostasis: ATP-Dependent Ca Pump: $ I_{Ca,ATP} $","[604.0, 456.0, 1104.0, 504.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intracellular $ [Ca^{2+}]_{i} $ Homeostasis: ATP-Dependent ""]",subsection_heading,0.6,body_zone,body_like,none,True,True +12,26,text,"In human chondrocytes, $ [Ca^{2+}]_i $ is regulated by a combination of ion transporters, ion pumps, and intrinsic intracellular $ Ca^{2+} $ buffering mechanisms. As noted, there is evidence that $","[602.0, 505.0, 1105.0, 710.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,27,text,The $ Ca^{2+} $ pump ion transporter is electroneutral as a consequence of its ability to allow two $ H^{+} $ ions to move into the cell for each $ Ca^{2+} $ ion that is extruded per transport cycl,"[602.0, 711.0, 1106.0, 941.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,28,display_formula," $$ I_{Ca,ATP}=Imax_{Ca,ATP}\frac{[Ca^{2+}]_{i}}{[Ca^{2+}]_{i}+k_{Ca,ATP}} $$ ","[696.0, 959.0, 1011.0, 1015.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,29,formula_number,(38),"[1069.0, 976.0, 1101.0, 997.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,30,text,and,"[607.0, 1031.0, 643.0, 1053.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,short_fragment,False,True +12,31,display_formula, $$ \frac{d\mathbf{O}_{C}}{d t}=2x10^{5}[C a^{2+}]_{i}\left(1-\mathbf{O}_{C}\right)-476\mathbf{O}_{C} $$ ,"[693.0, 1065.0, 1019.0, 1108.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,32,formula_number,(39),"[1069.0, 1077.0, 1102.0, 1098.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,33,text,"where $ I_{\text{max}} = 0.6349 \, \text{pA/pF} $ is the maximal $ Ca^{2+} $ pump current density, $ k_{Ca,ATP} $ is the half-maximum $ Ca^{2+} $ binding concentration, $ (0.0002 \, \text{mmol/L}","[605.0, 1122.0, 1104.0, 1239.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,34,paragraph_title,Transient Receptor Potential (TRP) Current: $ I_{TRPV4} $,"[606.0, 1255.0, 1071.0, 1278.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Transient Receptor Potential (TRP) Current: $ I_{TRPV4} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +12,35,text,"A fundamental question concerning the electrophysiology of non-excitable cells is: how do they sense the external environment and what ion flux mechanism(s) are responsible for this ""trigger/transduce","[604.0, 1278.0, 1106.0, 1418.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,36,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,37,number,12,"[586.0, 1483.0, 606.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,38,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1481.0, 1104.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,0,header,Maleckar et al.,"[86.0, 56.0, 180.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,2,text,"of ion channels (Nilius and Oswianik, 2011; Kaneko and Szallasi, 2014) are expressed in mammalian chondrocytes (cf. Gavenis et al., 2009; Phan et al., 2009; Clark et al., 2010; Asmar et al., 2016). Sp","[82.0, 123.0, 584.0, 511.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,text,We have identified significant TRP currents in human articular chondrocyte (HAC) preparations after superfusion with novel “TRPV4 activator” compounds synthesized by Glaxo Smith Kline (GSK) (Thorneloe,"[82.0, 512.0, 585.0, 652.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"and a variety of other published results we have formulated +the working hypothesis that, in the human chondrocyte, there +is a multicomponent signaling complex that includes: TRP +channels, Ca2+-activat","[602.0, 122.0, 1107.0, 375.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,paragraph_title,GSK SB488-induced currents in voltage-clamped human chondrocytes,"[603.0, 399.0, 1068.0, 446.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: GSK SB488-induced currents in voltage-clamped human chondroc""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +13,6,text,"The GSK compound SB488 is a potent agonist for TRPV4 channels (Nilius and Oswianik, 2011; Hilfiker et al., 2013). Our preliminary work has shown that SB488 (1 μM) can induce large non-selective cation","[602.0, 446.0, 1106.0, 655.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,chart,,"[174.0, 692.0, 589.0, 1026.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,8,figure_title,B,"[178.0, 1012.0, 196.0, 1030.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +13,9,chart,,"[175.0, 1036.0, 591.0, 1298.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,10,chart,,"[618.0, 718.0, 1023.0, 1202.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,11,paragraph_title,FIGURE 8,"[96.0, 1321.0, 172.0, 1340.0]",figure_caption,0.9,"[""figure prefix matched: FIGURE 8""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +13,12,figure_title,"FIGURE 8 | Activation of TRPV4 channel currents by the GSK agonist, SB488, in human articular chondrocytes. (A) Time course of membrane current density changes at +100 (open circles) and −100 mV (clos","[90.0, 1319.0, 1089.0, 1419.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 8 | Activation of TRPV4 channel currents by the GSK a""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +13,13,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,14,number,13,"[585.0, 1483.0, 607.0, 1500.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,15,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1481.0, 1104.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,0,header,Maleckar et al.,"[86.0, 56.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,2,chart,,"[149.0, 141.0, 574.0, 592.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,3,chart,,"[603.0, 166.0, 1048.0, 582.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,4,figure_title,FIGURE 9 | Block of SB488-induced currents through TRPV4 channels by SB779. (A) Time course of membrane current changes at +100 (open circles) and −100 mV (closed circles) during repeated ramp voltage,"[95.0, 616.0, 1095.0, 697.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 9 | Block of SB488-induced currents through TRPV4 cha""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +14,5,text,preparations. Figure 8 shows a representative example of the time course and I-V relationships of the SB488-induced currents in a voltage-clamped HAC. Figure 8A consists of a plot of these membrane cu,"[83.0, 735.0, 584.0, 941.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,Examples of HAC I-V relations recorded before and during SB488 application are shown in Figure 8B. The baseline or control current was very small and its I–V was essentially linear over the entire pot,"[83.0, 942.0, 585.0, 1220.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,text,"A different GSK compound, SB779, (Hilfiker et al., 2013) can potently block the currents induced by SB488. It was also studied in our HAC preparations. The data in Figure 9 confirm that SB 799 is an e","[82.0, 1220.0, 585.0, 1429.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,8,text,"current was quickly blocked by application of SB779 (even in +the presence of SB488). This marked reduction of the SB488- +induced current by SB779 is consistent with either block of a +SB488 “receptor,”","[603.0, 735.0, 1106.0, 967.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,9,paragraph_title,DISCUSSION The Resting Membrane Potential in Human Chondrocytes,"[604.0, 995.0, 1103.0, 1086.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: DISCUSSION The Resting Membrane Potential in Human Chondrocy""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +14,10,footer,,"[604.0, 1033.0, 1103.0, 1086.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +14,11,text,The new electrophysiological data and first order mathematical model provided by this study add significantly to the previously published papers on fundamental mechanisms of human chondrocyte biology ,"[602.0, 1091.0, 1106.0, 1431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,12,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,13,number,14,"[585.0, 1483.0, 606.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,14,footer,September 2018 | Volume 9 | Article 974,"[854.0, 1481.0, 1104.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,0,header,Maleckar et al.,"[86.0, 57.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,2,text,"alterations in $ E_{m} $ can contribute to dynamic regulation of cell volume (Barrett-Jolley et al., 2010; Lewis et al., 2011).","[83.0, 123.0, 584.0, 168.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,3,text,"Given the technical difficulty of making accurate, reproducible recordings of transmembrane ionic currents in small cells that have large input resistances, our mathematical model provides an addition","[83.0, 169.0, 585.0, 467.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,4,text,"At this stage of model development our simulations do not fully reveal the ionic basis for $ E_m $ in isolated human chondrocytes. However, they provide further insight into the consistent finding th","[83.0, 468.0, 585.0, 857.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,5,paragraph_title,The Physiological Milieu of the Chondrocyte,"[84.0, 892.0, 440.0, 947.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: The Physiological Milieu of the Chondrocyte""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +15,6,text,"Classical knowledge of unusual physiologic milieu (see Table 1) within the articular joint yields the expectation that these conditions would be expected to regulate the $ E_m $, e.g., by altering th","[83.0, 949.0, 584.0, 1201.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,7,text,We were very interested in an additional mechanism through which changes in the osmolarity of the superfusate or extracellular solution may manifest themselves. It is well-known that changes in osmola,"[83.0, 1200.0, 584.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,8,text,"known that divalent or trivalent cations, (as well as charged +osmolytes) can effectively reduce the zeta potential component +of the overall membrane potential (Hille, 2001). Although +surface potential ","[603.0, 123.0, 1107.0, 536.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,9,text,Perhaps the strongest evidence that in situ the chondrocyte can exhibit significant surface membrane delimited zeta potentials (and restricted diffusion profiles) has been provided by both classical a,"[603.0, 537.0, 1106.0, 925.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,10,text,"As noted in the Introduction, the pH in the extracellular matrix can be somewhat acidic, ~6.9 as opposed to 7.2 (see Table 1). Changes in $ [H^+]_0 $ measured in terms of pH alteration can also have ","[603.0, 926.0, 1105.0, 1109.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,11,text,"Other conditions that characterize the milieu mammalian articular chondrocyte would also be expected to have very significant electrophysiological consequences, mainly by altering $ E_m $. Perhaps th","[602.0, 1110.0, 1106.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,12,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,13,number,15,"[585.0, 1483.0, 606.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,14,footer,September 2018 | Volume 9 | Article 974,"[854.0, 1481.0, 1104.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,0,header,Maleckar et al.,"[86.0, 56.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,2,chart,,"[103.0, 129.0, 552.0, 1140.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,3,figure_title,"FIGURE 10 | Demonstration of the effects of in silico changes in the voltage-dependence for activation of the delayed rectifier K⁺ current, I_K–DR Panels (A,B), illustrate the altered activation curve","[92.0, 1167.0, 572.0, 1416.0]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 10 | Demonstration of the effects of in silico change""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +16,4,text,by the black traces in Figure 10C. Note that when $ [Na^+]_{i} $ is increased (8.6 to 15 mM) the extra outward $ Na^+/K^+ $ pump current can significantly hyperpolarize the chondrocyte $ E_m $. Aft,"[604.0, 123.0, 1106.0, 377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,5,text,"Ca²⁺-Influx and Ca²⁺-Dependent Currents +As noted, activation of TRPV4 channels would be expected to result in a significant influx of Ca²⁺ and Na⁺, and a related depolarization, when the chondrocyte m","[598.0, 396.0, 1107.0, 1066.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,paragraph_title,Connexin-Mediated Current Flow and Electrotonic Interactions,"[605.0, 1076.0, 1041.0, 1129.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Connexin-Mediated Current Flow and Electrotonic Interactions""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +16,7,text,"As mentioned in the Introduction, chondrocytes in articular joints from adult humans function as isolated, single cells. Interestingly, however, Cell Physiological data from early adolescent articular","[604.0, 1131.0, 1106.0, 1361.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,8,text,"We also note that is Cx43 increased expression in isolated adult chondrocytes can result in release ATP in response to e.g. mechanical perturbations (Millward-Sadler et al., 2004; Knight","[604.0, 1361.0, 1105.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,9,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,10,number,16,"[586.0, 1483.0, 606.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,11,footer,September 2018 | Volume 9 | Article 974,"[855.0, 1481.0, 1104.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,0,header,Maleckar et al.,"[86.0, 56.0, 179.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858.0, 56.0, 1103.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,2,text,"et al., 2009; Garcia and Knight, 2010). One plausible mechanism for this, is the occurrence of transient openings of these “hemichannels” that consist of either pannexin or connexin subunits (Saez et ","[83.0, 122.0, 584.0, 513.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,3,paragraph_title,Limitations of the Mathematical Model of the Human Chondrocyte Resting Membrane Potential,"[84.0, 528.0, 561.0, 611.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Limitations of the Mathematical Model of the Human Chondrocy""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +17,4,text,"The mathematical model that we have developed is an important advance. However, we recognize that it has significant limitations. These include:","[83.0, 612.0, 584.0, 682.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,5,text,"a) It is apparent that Ca²⁺ is an essential signaling molecule in the chondrocyte. Expression of L-type Ca²⁺ channels has been reported in growth plate chondrocytes (Sugimoto et al., 1996; Zuscik et a","[82.0, 691.0, 584.0, 1012.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,6,text,"b) Mathematical expressions that would allow simulations of what has been termed “the AM and FM modes of Ca²⁺ signaling” (Berridge, 1997; Berridge et al., 2000), will require consideration of $ [Ca^{","[82.0, 1014.0, 583.0, 1197.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,text,"c) There is evidence that cell culture conditions can alter both chondrocyte phenotype and gene expression profiles (Spitzer et al., 2000; Chen et al., 2012; but see Asmar et al., 2016). These pattern","[84.0, 1197.0, 585.0, 1428.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,8,paragraph_title,SUMMARY,"[605.0, 118.0, 740.0, 145.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: SUMMARY""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +17,9,text,This mathematical model of chondrocyte electrophysiology provides a reliable platform for integrating and evaluating both recent and well-established experimental data that is relevant to the generati,"[602.0, 163.0, 1107.0, 741.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,10,paragraph_title,AUTHOR CONTRIBUTIONS,"[604.0, 762.0, 924.0, 789.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: AUTHOR CONTRIBUTIONS""]",section_heading,0.6,body_zone,support_like,none,True,True +17,11,text,"RBC carried out all of the experimental work in this paper, and provided valuable input into the development and validation of the mathematical model. MM when supervising Dr. H. Narayanan at Simula Re","[603.0, 806.0, 1107.0, 1064.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,12,paragraph_title,ACKNOWLEDGMENTS,"[604.0, 1084.0, 876.0, 1110.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +17,13,text,"An Alberta Innovates—Health Solutions (AI-HS) Scientist Award (WRG), an AI-HS Starter Grant, and a Canadian Institutes of Health Research Grant were combined to support this experimental work and rela","[602.0, 1131.0, 1107.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,14,footer,Frontiers in Physiology | www.frontiersin.org,"[86.0, 1482.0, 353.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,15,number,17,"[585.0, 1483.0, 606.0, 1499.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,16,footer,September 2018 | Volume 9 | Article 974,"[854.0, 1481.0, 1104.0, 1501.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +18,0,header,Maleckar et al.,"[86.0, 57.0, 179.0, 75.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858.0, 56.0, 1103.0, 76.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +18,2,text,"aspects of the computational work in this paper. Glaxo Smith Kline Laboratories in Philadelphia, Pennsylvania supplied the human chondrocyte cell line and TRPV4 agonists/antagonists that were used to ","[84.0, 123.0, 584.0, 232.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,3,paragraph_title,REFERENCES,"[86.0, 292.0, 254.0, 317.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +18,4,paragraph_title,SUPPLEMENTARY MATERIAL,"[605.0, 118.0, 951.0, 145.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: SUPPLEMENTARY MATERIAL""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +18,5,text,The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphys.2018.00974/full#supplementary-material,"[603.0, 164.0, 1104.0, 234.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,6,reference_content,"Amanatullah, D. 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Physiol. 557, 93–104. doi: 10.1113/jphysiol.2003.058883","[106.0, 127.0, 581.0, 162.0]",reference_item,0.85,"[""reference content label: acutely isolated canine articular chondrocytes. J. Physiol. ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,3,reference_content,"Wilusz, R. E., Sanchez-Adams, J., and Guilak, F. (2014). The structure and function of the pericellular matrix of articular cartilage. Matrix Biol. 39, 25–32. doi: 10.1016/j.matbio.2014.08.009","[89.0, 164.0, 582.0, 219.0]",reference_item,0.85,"[""reference content label: Wilusz, R. E., Sanchez-Adams, J., and Guilak, F. (2014). The""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,4,reference_content,"Wright, M. O., Nishida, K., Bavington, C., Godolphin, J. L., Dunne, E., Walmsley, S., et al. (1997). Hyperpolarisation of cultured human chondrocytes following cyclical pressure-induced strain: eviden","[89.0, 222.0, 582.0, 331.0]",reference_item,0.85,"[""reference content label: Wright, M. O., Nishida, K., Bavington, C., Godolphin, J. L.,""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,5,reference_content,"Wu, Q. Q., and Chen, Q. (2000). Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Exp. Cell Res. 256, 383–3","[89.0, 336.0, 582.0, 408.0]",reference_item,0.85,"[""reference content label: Wu, Q. Q., and Chen, Q. (2000). Mechanoregulation of chondro""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,6,reference_content,"Zuscik, M. J., Gunter, T. E., Puzas, J. E., Rosier, R. N. (1997). Characterization of voltage-sensitive calcium channels in growth plate chondrocytes. Biochem. Biophys. Res. Commun. 234, 432–438. doi:","[607.0, 128.0, 1102.0, 182.0]",reference_item,0.85,"[""reference content label: Zuscik, M. J., Gunter, T. E., Puzas, J. E., Rosier, R. N. (1""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,7,reference_content,Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of inter,"[606.0, 202.0, 1103.0, 259.0]",reference_item,0.85,"[""reference content label: Conflict of Interest Statement: The authors declare that the""]",reference_item,0.85,reference_zone,support_like,none,True,True +21,8,reference_content,"Copyright © 2018 Maleckar, Clark, Votta and Giles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 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This equation includes all tran", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:9", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The intracellular concentrations of Na+, [Na+]i and K+, [K+]i, are governed by t", + "found_in_fulltext": true, + "fulltext_offset": 18410 + }, + { + "block_id": "p4:10", + "page": 4, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ \\frac{d[Na^{+}]_{i}}{dt}=\\frac{-(I_{Na,b}+3I_{NaK}+3I_{NaCa}-I_{NaH})}{\\nu o ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:11", + "page": 4, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(2)", + "found_in_fulltext": true, + "fulltext_offset": 18853 + }, + { + "block_id": "p4:12", + "page": 4, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "and", + "found_in_fulltext": true, + "fulltext_offset": 24 + }, + { + "block_id": "p4:13", + "page": 4, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ \\frac{d[K^{+}]_{i}}{dt}=\\frac{-(I_{K,b}-2I_{NaK}+I_{K-DR}+I_{K-2p}+I_{K-Ca}+I", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:14", + "page": 4, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(3)", + "found_in_fulltext": true, + "fulltext_offset": 18876 + }, + { + "block_id": "p4:15", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "where $ vol_i $ is the internal volume of the chondrocyte (calculated to be 0.00", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:16", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Intracellular Ca²⁺ concentration, [Ca²⁺]ᵢ, also changes with time, due to transm", + "found_in_fulltext": true, + "fulltext_offset": 19616 + }, + { + "block_id": "p4:17", + "page": 4, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ \\frac{d\\left[Ca^{2+}\\right]_{i}}{dt}=\\frac{\\left(I_{NaCa}-I_{Ca,ATP}\\right)}{", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:18", + "page": 4, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(4)", + "found_in_fulltext": true, + "fulltext_offset": 42570 + }, + { + "block_id": "p4:19", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "where $ O_c $ is the fraction of intracellular calmodulin bound to $ Ca^{2+} $ (", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:20", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Differential equations (1–4) and those for $ I_{K,Ca} $ and calmodulin buffering", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:21", + "page": 4, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "RESULTS Ion-Selective Transmembrane Currents Potassium Currents", + "found_in_fulltext": true, + "fulltext_offset": 20392 + }, + { + "block_id": "p4:23", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "We have identified and partially characterized three different $ K^{+} $ current", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:24", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Frontiers in Physiology | www.frontiersin.org", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:25", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "4", + "found_in_fulltext": true, + "fulltext_offset": 280 + }, + { + "block_id": "p4:26", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "September 2018 | Volume 9 | Article 974", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:0", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Maleckar et al.", + "found_in_fulltext": true, + "fulltext_offset": 20192 + }, + { + "block_id": "p5:1", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Chondrocyte K⁺ Currents Modulate E_m", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:4", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "K⁺ channels, I_K-2p; and (iii) a large conductance voltage and Ca²⁺-activated K⁺", + "found_in_fulltext": true, + "fulltext_offset": 20930 + }, + { + "block_id": "p5:5", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A typical pattern of K⁺ currents from our patch clamp recordings using single is", + "found_in_fulltext": true, + "fulltext_offset": 21437 + }, + { + "block_id": "p5:6", + "page": 5, + "role": "body_paragraph", + "zone": "display_zone", + "render_default": true, + "snippet": "Figure 2B consists of an averaged isochronal current-voltage (I–V) relationship ", + "found_in_fulltext": true, + "fulltext_offset": 22144 + }, + { + "block_id": "p5:7", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "in cell size. 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"body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Further information regarding the functional properties of this BK channel-media", + "found_in_fulltext": true, + "fulltext_offset": 32863 + }, + { + "block_id": "p9:4", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Although, $ I_{K-Ca} $ is a major outward current in human chondrocytes, it appa", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:5", + "page": 9, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2-Pore $ K^{+} $ current: $ I_{K-2p} $", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:6", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Our previous work (Clark et al., 2011) defined recording conditions under which ", + "found_in_fulltext": true, + "fulltext_offset": 34044 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Accordingly,", + "found_in_fulltext": true, + "fulltext_offset": 35284 + }, + { + "block_id": "p10:3", + "page": 10, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ I_{K-2p}=\\frac{P_{k}z^{2}V F^{2}}{R T}\\frac{\\left(\\left[K^{+}\\right]_{i}-\\lef", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:4", + "page": 10, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(20)", + "found_in_fulltext": true, + "fulltext_offset": 35965 + }, + { + "block_id": "p10:5", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "where $ P_K $ is a $ [K^+] $-dependent scaling factor that describes the permeab", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:6", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The I–V relationship in Figure 6A shows that our primary data (Wilson et al., 20", + "found_in_fulltext": true, + "fulltext_offset": 35750 + }, + { + "block_id": "p10:8", + "page": 10, + "role": "figure_caption_candidate", + "zone": "body_zone", + "render_default": false, + "snippet": "Voltage (mV)", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:12", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "As illustrated in Table 1, the extracellular milieu of the chondrocyte is somewh", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:13", + "page": 10, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "ATP-sensitive $ K^{+} $ current: $ I_{K-ATP} $", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:14", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "An ATP-sensitive K⁺ current I_K-ATP has been identified in chondrocytes that wer", + "found_in_fulltext": true, + "fulltext_offset": 36182 + }, + { + "block_id": "p10:15", + "page": 10, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ I_{K-,A T P}=\\sigma g_{o}p_{o}f_{A T P}(\\mathbf{V}-\\mathbf{E_{K}}) $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:16", + "page": 10, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(21)", + "found_in_fulltext": true, + "fulltext_offset": 37326 + }, + { + "block_id": "p10:17", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "where $ \\sigma = 0.6 $ is the channel density, $ g_o $ is the unitary channel co", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:18", + "page": 10, + "role": "unknown_structural", + "zone": "body_zone", + 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background (inward) $ Na^{+} $ and (outward) $ K^{+} $ currents, are describ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:5", + "page": 11, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ I_{Na,b}\\;=\\;G_{Na,b}(\\mathrm{V}-\\mathrm{E_{Na}}) $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:6", + "page": 11, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(26)", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:7", + "page": 11, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ I_{K,b}=G_{K,b}(\\mathbf{V}-\\mathbf{E_{K}}) $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:8", + "page": 11, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(27)", + 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"render_default": true, + "snippet": "We have used the equations originally developed by Crampin and Smith (2006) to m", + "found_in_fulltext": true, + "fulltext_offset": 43581 + }, + { + "block_id": "p12:10", + "page": 12, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ I_{NaH}=N_{NaH}I_{NaH_{mod}}I_{NaH_{exch}} $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:11", + "page": 12, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "(31)", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:12", + "page": 12, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ I_{NaHmod}=\\frac{1}{1+(K_{i}^{n_{H}}/\\left[H^{+}\\right]_{i}^{n_{H}}} $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:13", + "page": 12, + "role": "unknown_structural", + "zone": 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One plausible mechanism for this, is the", + "found_in_fulltext": true, + "fulltext_offset": 65102 + }, + { + "block_id": "p17:3", + "page": 17, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Limitations of the Mathematical Model of the Human Chondrocyte Resting Membrane ", + "found_in_fulltext": true, + "fulltext_offset": 66153 + }, + { + "block_id": "p17:4", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The mathematical model that we have developed is an important advance. However, ", + "found_in_fulltext": true, + "fulltext_offset": 66243 + }, + { + "block_id": "p17:5", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "a) It is apparent that Ca²⁺ is an essential signaling molecule in the chondrocyt", + "found_in_fulltext": true, + "fulltext_offset": 66388 + }, + { + "block_id": "p17:6", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "b) Mathematical expressions that would allow simulations of what has been termed", + "found_in_fulltext": true, + "fulltext_offset": 67192 + }, + { + "block_id": "p17:7", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "c) There is evidence that cell culture conditions can alter both chondrocyte phe", + "found_in_fulltext": true, + "fulltext_offset": 67663 + }, + { + "block_id": "p17:8", + "page": 17, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "SUMMARY", + "found_in_fulltext": true, + "fulltext_offset": 68253 + }, + { + "block_id": "p17:9", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This mathematical model of chondrocyte electrophysiology provides a reliable pla", + "found_in_fulltext": true, + "fulltext_offset": 68261 + }, + { + "block_id": "p17:10", + "page": 17, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "AUTHOR CONTRIBUTIONS", + "found_in_fulltext": true, + "fulltext_offset": 69775 + }, + { + "block_id": "p17:11", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "RBC carried out all of the experimental work in this paper, and provided valuabl", + "found_in_fulltext": true, + "fulltext_offset": 69798 + }, + { + "block_id": "p17:12", + "page": 17, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "ACKNOWLEDGMENTS", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p17:13", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "An Alberta Innovates—Health Solutions (AI-HS) Scientist Award (WRG), an AI-HS St", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p17:14", + "page": 17, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Frontiers in Physiology | www.frontiersin.org", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p17:15", + "page": 17, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "17", + "found_in_fulltext": true, + "fulltext_offset": 28509 + }, + { + "block_id": "p17:16", + "page": 17, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "September 2018 | Volume 9 | Article 974", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p18:0", + "page": 18, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Maleckar et al.", + "found_in_fulltext": true, + "fulltext_offset": 20192 + }, + { + "block_id": "p18:1", + "page": 18, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Chondrocyte K⁺ Currents Modulate Eᵐ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p18:2", + "page": 18, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "aspects of the computational work in this paper. 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inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p10:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_010.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:3", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:18", + "p1:19", + "p2:0", + "p2:1", + "p2:3", + "p2:9", + "p3:0", + "p3:1", + "p4:0", + "p5:0", + "p5:1", + "p5:4", + "p6:0", + "p6:1" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/4DU8LEH2/audit_report.md b/audit/4DU8LEH2/audit_report.md new file mode 100644 index 00000000..81a2e887 --- /dev/null +++ b/audit/4DU8LEH2/audit_report.md @@ -0,0 +1,36 @@ +# OCR Truth Audit Report - 4DU8LEH2 + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 5, 6, 7, 8, 9, 10] +- Reviewed blocks: 117 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/4DU8LEH2/audit_scope.json b/audit/4DU8LEH2/audit_scope.json new file mode 100644 index 00000000..eb3664a4 --- /dev/null +++ b/audit/4DU8LEH2/audit_scope.json @@ -0,0 +1,1490 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 3, + 5, + 6, + 7, + 8, + 9, + 10 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p3:2", + "p5:2", + "p5:4", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p6:5", + "p6:6", + "p7:0", + "p7:1", + "p8:0", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p9:0", + 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label 'aside_text'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,short_fragment,False,True +1,2,header_image,,"[4.0, 59.0, 72.0, 133.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,3,header,1997,"[565.0, 50.0, 627.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,text,"© 2022 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.","[228.0, 97.0, 962.0, 120.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2022 The Authors. Orthopaedic Surgery published by Tianjin""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,5,text,CLINICAL ARTICLE,"[462.0, 161.0, 716.0, 191.0]",authors,0.6,"[""page-1 initial-lastname author byline: CLINICAL ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,6,doc_title,"The Correlation between Various Shoulder +Anatomical Indices on X-Ray and Subacromial +Impingement and Morphology of Rotator +Cuff Tears","[135.0, 218.0, 1056.0, 419.0]",paper_title,0.8,"[""page-1 zone title_zone: The Correlation between Various Shoulder\nAnatomical Indices ""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text,"Jinsong Yang, MD $ {}^{ID} $, Ming Xiang, PhD, Yiping Li, MD, Qing Zhang, MD $ {}^{ID} $, Fei Dai, MD $ {}^{ID} $","[213.0, 456.0, 976.0, 484.0]",authors,0.8,"[""page-1 zone author_zone: Jinsong Yang, MD $ {}^{ID} $, Ming Xiang, PhD, Yiping Li, M""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,8,text,"Sichuan Provincial Orthopedic Hospital Upper Arm Department, Chengdu, China","[297.0, 499.0, 893.0, 524.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: Sichuan Provincial Orthopedic Hospital Upper Arm Department,""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,9,abstract,Objectives: Rotator cuff injury caused by subacromial impingement presents different morphologies. This study aims to investigate the correlation between various shoulder anatomical indexes on X-ray w,"[103.0, 583.0, 1084.0, 652.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,abstract,Method: This retrospective study was carried out between January 2020 and May 2022. Patients who were diagnosed as sub-acromial impingement associated with rotator cuff tears (without tendon retractio,"[103.0, 665.0, 1088.0, 844.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,11,abstract,Results: We analyzed 92 shoulders from 92 patients with a mean age of $ 57.23 \pm 8.45 $ years. The AS in anterior tear group ( $ 29.32 \pm 6.91^\circ $) was significantly larger than that in middle ,"[103.0, 859.0, 1088.0, 1058.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,12,abstract,Conclusion: Acromion with a larger AS and a smaller LAA tend to cause anterior or posterior rotator cuff tears rather than middle tears in sub-acromial impingement. Meanwhile acromion with a larger AS,"[102.0, 1071.0, 1087.0, 1139.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,13,text,Key words: Sub-Acromial impingement; Rotator cuff tear; Arthroscopy; Morphology; Shoulder anatomy,"[104.0, 1151.0, 957.0, 1176.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,14,paragraph_title,Introduction,"[77.0, 1238.0, 193.0, 1260.0]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,15,text,"Sub-acromial impingement is a common cause of shoulder pain and is also a crucial extrinsic predisposing factor for rotator cuff injury. $ ^{1,2} $ Shoulder standard A-P (anterior-posterior) view and ","[76.0, 1261.0, 583.0, 1311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,text,"factor for rotator cuff injury.1,2 Shoulder standard A-P +(anterior–posterior) view and outlet view on X-ray are the +most commonly used tools for the diagnosis of sub-","[606.0, 1237.0, 1114.0, 1311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,text,"Address for correspondence Ming Xiang, Sichuan Provincial Orthopedic Hospital Upper Arm Department, Chengdu, 610041, China. Email: joseceph_xm@sina.com +Received 30 August 2022; accepted 3 November 202","[75.0, 1362.0, 1109.0, 1418.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Address for correspondence Ming Xiang, Sichuan Provincial Or""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,18,footer,Orthopaedic Surgery 2023;15:1997-2006 · DOI: 10.1111/os.13610,"[78.0, 1473.0, 444.0, 1493.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,19,footer,"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is prope","[78.0, 1482.0, 1111.0, 1535.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,number,1998,"[565.0, 51.0, 627.0, 78.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328.0, 98.0, 581.0, 139.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,header,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[608.0, 99.0, 886.0, 119.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,text,"acromial impingement. $ ^{3-5} $ Previous studies have reported the correlation between various anatomical indices on shoulder X-ray and sub-acromial impingement. $ ^{6-9} $ However, no previous study","[74.0, 179.0, 583.0, 1101.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Therefore, the purpose of this study is to (i) summarize the shoulder anatomical indices and morphology of rotator cuff tear caused by subacromial impingement, (ii) investigate the correlation between","[75.0, 1100.0, 583.0, 1264.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,paragraph_title,Methods,"[77.0, 1284.0, 165.0, 1306.0]",section_heading,0.9,"[""explicit scholarly heading: Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,6,text,"Between January 2020 and May 2022, patients who were diagnosed as subacromial impingement associated with rotator cuff tear and received arthroscopic surgery were enrolled in this study. The study was","[75.0, 1307.0, 583.0, 1448.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"(1) the arthroscopic examination identified the tear was cau- +sed by impingement (the tear edge or surface was furry); +(2) there was no significant retraction of the rotator cuff; and +(3) the true anter","[606.0, 180.0, 1113.0, 409.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +2,8,text,"The radiographic indices of acromial slope (AS), acromial tilt (AT), lateral acromial angle (LAA), acromial Index (AI), and sub-acromial distance (SAD) were measured on preoperative true AP view and o","[605.0, 410.0, 1114.0, 689.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,paragraph_title,Measurement of Radiographic Indices Acromial Slope (AS),"[607.0, 709.0, 931.0, 777.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Measurement of Radiographic Indices Acromial Slope (AS)""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,False,True +2,10,footer,,"[607.0, 753.0, 779.0, 777.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,11,text,"AS was measured on the outlet-view X-ray. First, a line was drawn connecting the midway point and the most anterior point of the acromion inferior edge. Then, another line was drawn connecting the mid","[606.0, 777.0, 1114.0, 942.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,12,paragraph_title,Acromial Tilt (AT),"[607.0, 962.0, 769.0, 986.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Acromial Tilt (AT)""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,13,text,"The AT was measured on the outlet-view X-ray. First, a line was drawn connecting the most anterior point and the most posterior point of the acromion inferior edge. Then, another line was drawn connec","[606.0, 985.0, 1113.0, 1149.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,paragraph_title,Lateral Acromial Angle (LAA),"[607.0, 1169.0, 861.0, 1192.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Lateral Acromial Angle (LAA)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,15,text,"The LAA was measured on the true anteroposterior (AP)-view X-ray. First, a line was drawn connecting the uppermost point and the lowermost point of the lateral glenoid. Then, another line was drawn pa","[605.0, 1191.0, 1113.0, 1334.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,16,paragraph_title,Acromion Index (AI),"[607.0, 1353.0, 787.0, 1376.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Acromion Index (AI)""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,17,text,"The AI was measured on the true anteroposterior (AP) view X-ray. First, a lateral glenoid line was drawn connecting the uppermost point and the lowermost point of the lateral","[605.0, 1375.0, 1114.0, 1449.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,number,1999,"[566.0, 51.0, 626.0, 77.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328.0, 99.0, 581.0, 139.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,image,,"[367.0, 188.0, 1110.0, 1264.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,"Fig. 1 The various shoulder anatomical indices measured on X-ray. (A) acromial slope (AS), (B) acromial tilt (AT), (C) lateral acromial angle (LAA), (D) sub-acromial distance (SAD) and GA/GH-acromial ","[76.0, 1125.0, 349.0, 1292.0]",figure_caption,0.92,"[""figure_title label: Fig. 1 The various shoulder anatomical indices measured on X""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,"glenoid. Then, we measured the distance between the most lateral point of the acromion inferior edge and the lateral glenoid line as D1, and the distance between the most lateral point of the humeral ","[77.0, 1323.0, 583.0, 1465.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Sub-Acromial Distance (SAD),"[608.0, 1322.0, 856.0, 1347.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Sub-Acromial Distance (SAD)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,6,text,The SAD was measured on the true anteroposterior (AP) view X-ray. A line was drawn between the midpoint of the acromion inferior edge and the uppermost point of the humeral head. The length of the lin,"[606.0, 1345.0, 1115.0, 1464.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,2000,"[563.0, 51.0, 627.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,text,"ORTHOPAEDIC SURGERY +VOLUME 15·NUMBER 8·AUGUST, 2023 +SHOULDER ANATOMY AND ROTATOR CUFF TEAR","[327.0, 97.0, 581.0, 139.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,2,text,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[608.0, 99.0, 885.0, 119.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,Measurement of the Location and Morphology of Rotator Cuff Tears Tear Location in the Anterior to Posterior Direction,"[77.0, 180.0, 502.0, 270.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Measurement of the Location and Morphology of Rotator Cuff T""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,4,footer,,"[77.0, 248.0, 502.0, 270.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,5,text,Tear location must be viewed from a standard arthroscopic lateral portal. If the tear site was located in the anterior rotator cuff and the biceps tendon could be visually identified directly or by th,"[75.0, 272.0, 583.0, 571.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Tear Location in the Medial to Lateral Direction,"[77.0, 616.0, 476.0, 639.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Tear Location in the Medial to Lateral Direction""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,7,text,"Tear location should be viewed from a standard arthroscopic lateral portal. If the most lateral part of the tear was located more than 5 mm to the most lateral edge of the footprint, then the tear was","[75.0, 639.0, 581.0, 756.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,paragraph_title,Tear Morphology,"[77.0, 801.0, 226.0, 824.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Tear Morphology""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +4,9,text,"Tear location should be viewed from a standard arthroscopic lateral portal. If the tear ran in the medial to lateral direction, then the tear was defined as a longitudinal tear. If the tear ran in the","[74.0, 823.0, 583.0, 1010.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,All radiographic measurements were made by two experienced arthroscopic surgeons independently. Inter-observer consistency tests were performed and the average of the two measurements was taken as the,"[74.0, 1009.0, 582.0, 1196.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,paragraph_title,Statistical Analysis,"[77.0, 1238.0, 244.0, 1260.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical Analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,12,text,"SPSS version 22.0 (SPSS, Inc., Chicago, IL) was used to perform the statistical analysis. The comparisons of different radiographic indices between groups (anterior, middle, posterior group and horizo","[75.0, 1261.0, 582.0, 1471.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,paragraph_title,Results,"[608.0, 179.0, 687.0, 201.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,14,text,"In total, we analyzed 92 shoulders of 92 patients (33 males and 59 females). Mean age was $ 57.23 \pm 8.45 $ years. There were 64 right shoulders and 28 left shoulders. On average, $ 2.13 \pm 0.65 $","[603.0, 204.0, 1116.0, 805.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,15,paragraph_title,"Comparison between Groups of Different Tear Locations (Anterior, Middle, and Posterior)","[606.0, 824.0, 1086.0, 870.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Comparison between Groups of Different Tear Locations (Anter""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,16,text,"The radiographic indices in the anterior tear, middle tear, and posterior tear groups are shown in Table 2. The AS in the anterior tear group $ (29.32 \pm 6.91^\circ) $ was significantly larger than ","[605.0, 871.0, 1114.0, 1172.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,17,paragraph_title,"Comparison between Groups of Different Tear Shapes (Horizontal, Longitudinal, L-Shaped, and Irregular)","[605.0, 1192.0, 1063.0, 1238.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Comparison between Groups of Different Tear Shapes (Horizont""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,18,text,"The radiographic indices in the horizontal tear, longitudinal tear, L-shaped tear, and irregular tear groups are shown in Table 3. The AS in the longitudinal tear group (26.86 ± 8.41°) was significant","[605.0, 1239.0, 1114.0, 1470.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,2001,"[564.0, 51.0, 624.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328.0, 99.0, 581.0, 139.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,image,,"[168.0, 182.0, 1025.0, 939.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +5,3,figure_title,"Fig. 2 The different locations and shapes of rotator cuff tears caused by sub-acromial impingement. (A) Anterior tear, (B) middle tear, (C) posterior tear, (D) horizontal tear, (E) longitudinal tear, ","[77.0, 962.0, 1090.0, 1009.0]",figure_caption,0.92,"[""figure_title label: Fig. 2 The different locations and shapes of rotator cuff te""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,table,"
TABLE 1 General data of patients in each group
AntMidPosHoriLongL-shaIrrMed
TABLE 2 Comparison of radiographic indices between anterior tear, middle tear and posterior tear group
AS ( $ ^{\circ} $)AT ( $ ^{\circ} $","[81.0, 190.0, 1105.0, 408.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,2,chart,,"[92.0, 508.0, 574.0, 775.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,3,chart,,"[610.0, 504.0, 1096.0, 776.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,4,chart,,"[87.0, 802.0, 570.0, 1069.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,chart,,"[614.0, 800.0, 1102.0, 1072.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,6,chart,,"[359.0, 1099.0, 849.0, 1369.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,7,figure_title,"Fig. 3 Comparison of radiographic indices between the anterior tear, middle tear, and posterior tear groups. AS, acromial slope; AT, acromial tilt; LAA, lateral acromial angle; AI, acromial index; SAD","[77.0, 1392.0, 1090.0, 1439.0]",figure_caption,0.92,"[""figure_title label: Fig. 3 Comparison of radiographic indices between the anteri""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,0,figure_title,2003,"[562.0, 50.0, 628.0, 79.0]",figure_caption_candidate,0.85,"[""figure_title label: 2003""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False +7,1,table,"
TABLE 3 Comparison of radiographic indices in the horizontal tear, longitudinal tear, L-shaped tear and irregular tear group
AS ( $ ^{\circ} $)
TABLE 4 Comparison of radiographic indices in the medial tear and lateral tear group
AS ( $ ^{\circ} $)AT ( $ ^{\circ} $)LAA ( $ ","[81.0, 1144.0, 1104.0, 1344.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +8,4,vision_footnote,"Abbreviations: AI, acromial index; AS, acromial slope; AT, acromial tilt; LAA, lateral acromial angle; SAD, subacromial distance.","[97.0, 1320.0, 873.0, 1341.0]",footnote,0.7,"[""vision_footnote label: Abbreviations: AI, acromial index; AS, acromial slope; AT, a""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +8,5,text,"contact area was mainly a specific point; with shoulder abduction, the track was similar to a line running from medial to lateral. $ ^{25} $ However, if the contact area was a line, with shoulder abdu","[76.0, 1394.0, 583.0, 1465.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +8,6,text,"with shoulder abduction, the acromion edge worked like a +guillotine and a horizontal tear would be formed. Unlike the +medium to large rotator cuff tears (the L-shaped tear was","[605.0, 1393.0, 1114.0, 1466.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,0,header,2005,"[563.0, 50.0, 627.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +9,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328.0, 98.0, 581.0, 139.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +9,2,header,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[323.0, 98.0, 886.0, 138.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +9,3,text,"mainly formed by tendon retraction), the L-shaped tears observed in this study were caused by impingement. The contact area was not solitary; in contrast, the two contacting methods mentioned above (p","[74.0, 180.0, 584.0, 1127.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +9,4,paragraph_title,Clinical Translation,"[77.0, 1147.0, 254.0, 1168.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical Translation""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True +9,5,text,"The location of rotator cuff tears can differ; consequently, patients tend to complain about shoulder pain in different locations. Our analyses suggest that the location of potential rotator cuff tear","[74.0, 1169.0, 584.0, 1449.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +9,6,text,"be predicted from radiographic indices, thus allowing clini- +cians to guide the drug distribution.29 Patients with suba- +cromial impingement and poor radiographic indices may +require surgical interven","[604.0, 179.0, 1115.0, 598.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,7,paragraph_title,Strengths and Limitations,"[607.0, 622.0, 833.0, 645.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Strengths and Limitations""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True +9,8,text,"To the best of our knowledge, this is the first study to investigate the correlation between shoulder anatomical indices on X-ray and the morphology of rotator cuff tears with reliable statistical dat","[605.0, 645.0, 1114.0, 811.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,9,paragraph_title,Conclusion,"[608.0, 833.0, 710.0, 855.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True +9,10,text,"Acromion with a larger AS tend to cause anterior tears and middle tears rather than posterior tears, and is more likely to cause longitudinal tears rather than horizontal tears and L-shaped tears. Acr","[605.0, 856.0, 1114.0, 1043.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,11,paragraph_title,Acknowledgments,"[607.0, 1068.0, 781.0, 1090.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +9,12,text,"Thank you for the tacit teamwork of all authors. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.","[606.0, 1091.0, 1113.0, 1164.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,13,paragraph_title,Conflict of Interest,"[608.0, 1188.0, 786.0, 1210.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,True,True +9,14,text,The authors declared that they have no conflicts of interest for this work.,"[607.0, 1211.0, 1111.0, 1258.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,15,paragraph_title,Author's Contribution,"[608.0, 1284.0, 808.0, 1306.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author's Contribution""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True +9,16,text,"Jinsong Yang—study design, data collection, statistics, paper writing.","[608.0, 1308.0, 1113.0, 1353.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,17,text,Ming Xiang—operation implementation.,"[627.0, 1354.0, 966.0, 1378.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,18,text,Yiping Li—data collection.,"[628.0, 1377.0, 853.0, 1400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,19,text,Qing Zhang—data collection.,"[628.0, 1401.0, 874.0, 1423.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,20,text,Fei Dai—data collection.,"[628.0, 1424.0, 836.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +10,0,header,2006,"[565.0, 52.0, 626.0, 78.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,1,text,"ORTHOPAEDIC SURGERY +SHOULDER ANATOMY AND ROTATOR CUFF TEAR","[438.0, 101.0, 580.0, 117.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,2,text,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[609.0, 101.0, 885.0, 118.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,text,"VOLUME 15 · NUMBER 8 · AUGUST, 2023","[329.0, 119.0, 580.0, 137.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,paragraph_title,References,"[537.0, 216.0, 653.0, 236.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +10,5,reference_content,"1. Balke M, Liem D, Greshake O, Hoeher J, Bouillon B, Banerjee M. Differences in acromial morphology of shoulders in patients with degenerative and traumatic supraspinatus tendon tears. Knee Surg Spor","[78.0, 247.0, 568.0, 310.0]",reference_item,0.85,"[""reference content label: 1. Balke M, Liem D, Greshake O, Hoeher J, Bouillon B, Banerj""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,6,reference_content,"2. Balke M, Schmidt C, Dedy N, Banerjee M, Bouillon B, Liem D. Correlation of acromial morphology with impingement syndrome and rotator cuff tears. Acta Orthop. 2013;84:178–83.","[80.0, 312.0, 565.0, 359.0]",reference_item,0.85,"[""reference content label: 2. Balke M, Schmidt C, Dedy N, Banerjee M, Bouillon B, Liem ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,7,reference_content,"3. Blonna D, Giani A, Bellato E, Mattei L, Calo M, Rossi R, et al. Predominance of the critical shoulder angle in the pathogenesis of degenerative diseases of the shoulder. J Shoulder Elbow Surg. 2016","[79.0, 360.0, 579.0, 408.0]",reference_item,0.85,"[""reference content label: 3. Blonna D, Giani A, Bellato E, Mattei L, Calo M, Rossi R, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,8,reference_content,"4. Chalmers PN, Salazar D, Steger-May K, Chamberlain A, Yamaguchi K, Keener J. Does the critical shoulder angle correlate with rotator cuff tear progression? Clin Orthop Relat Res. 2017;475:1608–17.","[81.0, 409.0, 524.0, 455.0]",reference_item,0.85,"[""reference content label: 4. Chalmers PN, Salazar D, Steger-May K, Chamberlain A, Yama""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,9,reference_content,"5. Cherchi L, Ciornohac J, Godet J, Clavert P, Kempf J. Critical shoulder angle: measurement reproducibility and correlation with rotator cuff tendon tears. 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Watanabe A, Ono Q, Nishigami T, Hirooka T, Machida H. Dif""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,14,reference_content,"10. Güray A, Ismail T, Deniz K, et al. The effect of sagittal orientation of the acromion relative to the scapular spine on the location of rotator cuff tears. Acta Orthop Traumatol Turc. 2022;56:116–","[80.0, 699.0, 570.0, 746.0]",reference_item,0.85,"[""reference content label: 10. G\u00fcray A, Ismail T, Deniz K, et al. The effect of sagitta""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,15,reference_content,"11. Thi HT, Geun-Tae K, Taewoo K, et al. Classification of rotator cuff tears in ultrasound images using deep learning models. Med Biol Eng Comput. 2022;60:1269-78.","[80.0, 748.0, 571.0, 793.0]",reference_item,0.85,"[""reference content label: 11. Thi HT, Geun-Tae K, Taewoo K, et al. Classification of r""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,16,reference_content,"12. Plancher Kevin D, Jaya S, Karen B, et al. Diagnosis and Management of Partial Thickness Rotator Cuff Tears: a comprehensive review. J Am Acad Orthop Surg. 2021;29:1031–43.","[80.0, 795.0, 570.0, 843.0]",reference_item,0.85,"[""reference content label: 12. Plancher Kevin D, Jaya S, Karen B, et al. Diagnosis and ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,17,reference_content,"13. Leslie V, Carol C, Gaelan C, et al. Exploring clinician perceptions of a care pathway for the management of shoulder pain: a qualitative study. BMC Health Serv Res. 2022;22:702.","[80.0, 844.0, 563.0, 890.0]",reference_item,0.85,"[""reference content label: 13. Leslie V, Carol C, Gaelan C, et al. Exploring clinician ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,18,reference_content,"14. Escamilla Rafael F, Kyle Y, Lonnie P, et al. Shoulder muscle activity and function in common shoulder rehabilitation exercises. Sports Med. 2009;39:663–85.","[79.0, 891.0, 580.0, 923.0]",reference_item,0.85,"[""reference content label: 14. Escamilla Rafael F, Kyle Y, Lonnie P, et al. Shoulder mu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,19,reference_content,"15. Rony-Orijit DH, Erat Justin J, Rakowski Dylan R, et al. The evolution of arthroscopic rotator cuff repair. Orthop J Sports Med. 2021;9:23259671211050899.","[80.0, 924.0, 539.0, 970.0]",reference_item,0.85,"[""reference content label: 15. Rony-Orijit DH, Erat Justin J, Rakowski Dylan R, et al. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,20,reference_content,"16. Willenbring Taylor J, DeVos MJ, Warth Ryan J, et al. Trends in acromioplasty utilization during arthroscopic rotator cuff repair: an epidemiological study of 139,586 patients. J Am Acad Orthop Sur","[609.0, 249.0, 1095.0, 311.0]",reference_item,0.85,"[""reference content label: 16. Willenbring Taylor J, DeVos MJ, Warth Ryan J, et al. Tre""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,21,reference_content,"17. Ozgun K, Burak G, Selcuk K, et al. The effect of acromioplasty or bursectomy on the results of arthroscopic repair of full thickness rotator cuff tears: does the acromion type affect these results","[611.0, 313.0, 1099.0, 375.0]",reference_item,0.85,"[""reference content label: 17. Ozgun K, Burak G, Selcuk K, et al. The effect of acromio""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True +10,22,reference_content,18. Zaid MB et al. Anatomic shoulder parameters and their relationship to the presence of degenerative rotator cuff tears and glenohumeral osteoarthritis: a systematic review and meta-analysis. J Shou,"[611.0, 377.0, 1102.0, 424.0]",reference_item,0.85,"[""reference content label: 18. Zaid MB et al. Anatomic shoulder parameters and their re""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,23,reference_content,"19. Moor BK, Weiser K, Slankamenac K, Geber C, Bouaicha S. Relationship of individual scapular anatomy and degenerative rotator cuff shoulder anatomy and degenerative conditions 2465 tears. J Shoulder","[611.0, 426.0, 1101.0, 486.0]",reference_item,0.85,"[""reference content label: 19. Moor BK, Weiser K, Slankamenac K, Geber C, Bouaicha S. R""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,24,reference_content,"20. Xinyu L, Wei X, Ning H, et al. Relationship between acromial morphological variation and subacromial impingement: a three-dimensional analysis. PLoS One. 2017;12:e0176193.","[610.0, 488.0, 1104.0, 536.0]",reference_item,0.85,"[""reference content label: 20. Xinyu L, Wei X, Ning H, et al. Relationship between acro""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,25,reference_content,"21. Lionel P, Sophie B, Philippe M, et al. Multimodality imaging of subacromial impingement syndrome. Skeletal Radiol. 2018;47:923–37.","[611.0, 538.0, 1095.0, 568.0]",reference_item,0.85,"[""reference content label: 21. Lionel P, Sophie B, Philippe M, et al. Multimodality ima""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,26,reference_content,"22. Pogorzelski J, Beitzel K, Imhoff AB, Millett P, Braun S. Surgical treatment of anterosuperior impingement of the shoulder. Oper Orthop Traumatol. 2016;28:418–29.","[611.0, 570.0, 1099.0, 615.0]",reference_item,0.85,"[""reference content label: 22. Pogorzelski J, Beitzel K, Imhoff AB, Millett P, Braun S.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,27,reference_content,"23. Nazim K, Bans Y, Ahmet O, et al. Evaluation of critical shoulder angle and acromion index in patients with anterior shoulder instability and rotator cuff tear. Acta Orthop Traumatol Turc. 2021;55:","[610.0, 617.0, 1100.0, 664.0]",reference_item,0.85,"[""reference content label: 23. Nazim K, Bans Y, Ahmet O, et al. Evaluation of critical ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,28,reference_content,"24. Rugg Caitlin M, Gallo Robert A, Craig Edward V, et al. The pathogenesis and management of cuff tear arthropathy. J Shoulder Elbow Surg. 2018;27:2271-83.","[611.0, 666.0, 1091.0, 711.0]",reference_item,0.85,"[""reference content label: 24. Rugg Caitlin M, Gallo Robert A, Craig Edward V, et al. T""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,29,reference_content,"25. Frank Jonathan M, Jaskardip C, Frank Rachel M, et al. The role of acromioplasty for rotator cuff problems. Orthop Clin North Am. 2014;45:219–24","[611.0, 714.0, 1097.0, 745.0]",reference_item,0.85,"[""reference content label: 25. Frank Jonathan M, Jaskardip C, Frank Rachel M, et al. Th""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,30,reference_content,"26. Koca R, Fazliogullan Z, Aydin BK, et al. Acromion types and morphometric evaluation of painful shoulders. Folia Morphol. 2021.","[611.0, 741.0, 1102.0, 777.0]",reference_item,0.85,"[""reference content label: 26. Koca R, Fazliogullan Z, Aydin BK, et al. Acromion types ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,31,reference_content,"27. Qi M, Changjiao S, Ruiyong D, et al. Morphological characteristics of acromion and acromioclavicular joint in patients with shoulder impingement syndrome and related recommendations: a three-dimen","[611.0, 778.0, 1102.0, 855.0]",reference_item,0.85,"[""reference content label: 27. Qi M, Changjiao S, Ruiyong D, et al. Morphological chara""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,32,reference_content,"28. Page Matthew J, Sally G, Brodwen MB, et al. Manual therapy and exercise for rotator cuff disease. Cochrane Database Syst Rev. 2016;6:CD012224.","[611.0, 857.0, 1109.0, 889.0]",reference_item,0.85,"[""reference content label: 28. Page Matthew J, Sally G, Brodwen MB, et al. Manual thera""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +10,33,reference_content,"29. Ophelie L-G, Ghassan F, Yining L, et al. Physical therapy combined with subacromial cortisone injection is a first-line treatment whereas acromioplasty with physical therapy is best if nonoperativ","[610.0, 891.0, 1110.0, 968.0]",reference_item,0.85,"[""reference content label: 29. Ophelie L-G, Ghassan F, Yining L, et al. 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A line was dra", + "found_in_fulltext": true, + "fulltext_offset": 9932 + }, + { + "block_id": "p4:0", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "2000", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:1", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "ORTHOPAEDIC SURGERY VOLUME 15·NUMBER 8·AUGUST, 2023 SHOULDER ANATOMY AND ROTATOR", + "found_in_fulltext": true, + "fulltext_offset": 10436 + }, + { + "block_id": "p4:2", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "SHOULDER ANATOMY AND ROTATOR CUFF TEAR", + "found_in_fulltext": true, + "fulltext_offset": 10488 + }, + { + "block_id": "p4:3", + "page": 4, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Measurement of the Location and Morphology of Rotator Cuff Tears Tear Location i", + "found_in_fulltext": true, + "fulltext_offset": 10570 + }, + { + "block_id": "p4:5", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Tear location must be viewed from a standard arthroscopic lateral portal. If the", + "found_in_fulltext": true, + "fulltext_offset": 10688 + }, + { + "block_id": "p4:6", + "page": 4, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Tear Location in the Medial to Lateral Direction", + "found_in_fulltext": true, + "fulltext_offset": 11441 + }, + { + "block_id": "p4:7", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Tear location should be viewed from a standard arthroscopic lateral portal. 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If t", + "found_in_fulltext": true, + "fulltext_offset": 11490 + }, + { + "block_id": "p4:10", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "All radiographic measurements were made by two experienced arthroscopic surgeons", + "found_in_fulltext": true, + "fulltext_offset": 12273 + }, + { + "block_id": "p4:11", + "page": 4, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Statistical Analysis", + "found_in_fulltext": true, + "fulltext_offset": 12742 + }, + { + "block_id": "p4:12", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "SPSS version 22.0 (SPSS, Inc., Chicago, IL) was used to perform the statistical ", + "found_in_fulltext": true, + "fulltext_offset": 12763 + }, + { + "block_id": "p4:13", + "page": 4, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Results", + "found_in_fulltext": true, + "fulltext_offset": 1571 + }, + { + "block_id": "p4:14", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In total, we analyzed 92 shoulders of 92 patients (33 males and 59 females). 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TABLE 1 General data of patients in each group
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This research did not receive a", + "found_in_fulltext": true, + "fulltext_offset": 29179 + }, + { + "block_id": "p9:13", + "page": 9, + "role": "subsection_heading", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Conflict of Interest", + "found_in_fulltext": true, + "fulltext_offset": 29355 + }, + { + "block_id": "p9:14", + "page": 9, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "The authors declared that they have no conflicts of interest for this work.", + "found_in_fulltext": true, + "fulltext_offset": 29378 + }, + { + "block_id": "p9:15", + "page": 9, + "role": "subsection_heading", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Author's Contribution", + "found_in_fulltext": true, + "fulltext_offset": 29458 + }, + { + "block_id": "p9:16", + "page": 9, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Jinsong Yang—study design, data collection, statistics, paper writing.", + "found_in_fulltext": true, + "fulltext_offset": 29480 + }, + { + "block_id": "p9:17", + "page": 9, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Ming Xiang—operation implementation.", + "found_in_fulltext": true, + "fulltext_offset": 29551 + }, + { + "block_id": "p9:18", + "page": 9, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Yiping Li—data collection.", + "found_in_fulltext": true, + "fulltext_offset": 29588 + }, + { + "block_id": "p9:19", + "page": 9, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Qing Zhang—data collection.", + "found_in_fulltext": true, + "fulltext_offset": 29615 + }, + { + "block_id": "p9:20", + "page": 9, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Fei Dai—data collection.", + "found_in_fulltext": true, + "fulltext_offset": 29643 + }, + { + "block_id": "p10:0", + "page": 10, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "2006", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:1", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "ORTHOPAEDIC SURGERY SHOULDER ANATOMY AND ROTATOR CUFF TEAR", + "found_in_fulltext": true, + "fulltext_offset": 29685 + }, + { + "block_id": "p10:2", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "SHOULDER ANATOMY AND ROTATOR CUFF TEAR", + "found_in_fulltext": true, + "fulltext_offset": 10488 + }, + { + "block_id": "p10:3", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "VOLUME 15 · NUMBER 8 · AUGUST, 2023", + "found_in_fulltext": true, + "fulltext_offset": 29744 + }, + { + "block_id": "p10:4", + "page": 10, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": true, + "fulltext_offset": 29822 + }, + { + "block_id": "p10:5", + "page": 10, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. 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"critical", + "block_ids": [ + "p7:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p7:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_007.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:1", + "p1:2", + "p1:3", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:13", + "p2:0", + "p2:1", + "p2:5", + "p3:0", + "p3:1", + "p3:5", + "p3:6", + "p3:8", + "p3:9", + "p3:10", + "p3:12" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/4FY3VQJS/audit_report.md b/audit/4FY3VQJS/audit_report.md new file mode 100644 index 00000000..d5709bd7 --- /dev/null +++ b/audit/4FY3VQJS/audit_report.md @@ -0,0 +1,36 @@ +# OCR Truth Audit Report - 4FY3VQJS + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 4, 5, 6, 7] +- Reviewed blocks: 78 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/4FY3VQJS/audit_scope.json b/audit/4FY3VQJS/audit_scope.json new file mode 100644 index 00000000..aeff886e --- /dev/null +++ b/audit/4FY3VQJS/audit_scope.json @@ -0,0 +1,1057 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 3, + 4, + 5, + 6, + 7 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p3:6", + "p3:7", + "p3:8", + "p3:10", + "p3:13", + "p3:15", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p6:0", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p7:3", + "p7:4", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p7:12", + "p7:13", + "p7:14", + "p7:15", + "p7:16", + "p7:17", + "p7:18", + "p7:19", + "p7:20" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:9", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:10", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:11", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:12", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:13", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:14", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:15", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:16", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:17", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:18", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:19", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:6", + "page": 3, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:7", + "page": 3, + "required_reason": [ + "same_page_boundary" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:8", + "page": 3, + "required_reason": [ + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:10", + "page": 3, + "required_reason": [ + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:13", + "page": 3, + "required_reason": [ + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p3:15", + "page": 3, + "required_reason": [ + "same_page_boundary" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:0", + "page": 4, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:1", + "page": 4, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:2", + "page": 4, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:3", + "page": 4, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:4", + "page": 4, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:5", + "page": 4, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:6", + "page": 4, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:7", + "page": 4, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:8", + "page": 4, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p4:9", + "page": 4, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p5:0", + "page": 5, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + 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index 00000000..463b7088 --- /dev/null +++ b/audit/4FY3VQJS/block_trace.csv @@ -0,0 +1,92 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[83.0, 90.0, 187.0, 215.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header,Available online at www.sciencedirect.com,"[303.0, 90.0, 650.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,header,ScienceDirect,"[344.0, 135.0, 608.0, 166.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,Materials Today: Proceedings 3 (2016) 2113–2120,"[309.0, 188.0, 645.0, 212.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,header_image,,"[771.0, 110.0, 1001.0, 176.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,5,header,www.materialstoday.com/proceedings,"[750.0, 191.0, 1002.0, 212.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,6,text,Recent Advances In Nano Science And Technology 2015 (RAINSAT2015),"[70.0, 351.0, 714.0, 378.0]",authors,0.8,"[""page-1 zone author_zone: Recent Advances In Nano Science And Technology 2015 (RAINSAT""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,doc_title,Structural Characterization of Silver-Hydroxyapatite Nanocomposite: A Bone Repair Biomaterial,"[179.0, 428.0, 902.0, 505.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Structural Characterization of Silver-Hydroxyapatite Nanocom""]",authors,0.8,frontmatter_main_zone,support_like,none,False,True +1,8,text,"Amardeep Bharti $ ^{a,*} $, Suman Singh $ ^{b} $, Vijay Kumar Meena $ ^{b} $ and Navdeep Goyal $ ^{a} $","[126.0, 529.0, 956.0, 561.0]",authors,0.8,"[""page-1 zone author_zone: Amardeep Bharti $ ^{a,*} $, Suman Singh $ ^{b} $, Vijay Kuma""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,9,text," $ ^{a} $Department of physics, Panjab University, Chandigarh, INDIA-160014 + $ ^{b} $Central Scientific Instruments Organization, CSIR, Chandigarh, INDIA-160030","[277.0, 576.0, 804.0, 618.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $Department of physics, Panjab University, Chandigarh""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,10,paragraph_title,Abstract,"[70.0, 676.0, 145.0, 698.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,support_like,short_fragment,True,True +1,11,abstract,"Hydroxyapatite (HA) is a form of calcium & phosphate and constitutes large amount of human bone, dental enamel and dentin. HA is widely acceptable as purifier for proteins, drug delivery and body impl","[67.0, 721.0, 1012.0, 903.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,12,text,Selection and Peer-review under responsibility of [Conference Committee Members of Recent Advances In Nano Science and Technology 2015.].,"[70.0, 919.0, 988.0, 965.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,13,text,Keywords: Hydroxyapatite; Silver nanoparticles; Biomaterial; Anisotropic.,"[70.0, 985.0, 556.0, 1007.0]",structured_insert,0.7,"[""frontmatter noise text: Keywords: Hydroxyapatite; Silver nanoparticles; Biomaterial;""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,14,paragraph_title,1. Introduction,"[70.0, 1047.0, 206.0, 1069.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,15,text,"The area of biomaterials is an area of tremendous significance; engaged both material science and biological science, having aspiration to achieve a pertinent interaction between new material and huma","[68.0, 1094.0, 1016.0, 1142.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,footnote,* Corresponding author.,"[93.0, 1214.0, 259.0, 1234.0]",footnote,0.7,"[""footnote label: * Corresponding author.""]",footnote,0.7,body_zone,body_like,none,True,True +1,17,footnote,E-mail address: abharti@pu.ac.in,"[93.0, 1235.0, 319.0, 1255.0]",footnote,0.7,"[""footnote label: E-mail address: abharti@pu.ac.in""]",footnote,0.7,body_zone,body_like,none,True,True +1,18,footnote,2214-7853© 2015 Elsevier Ltd. All rights reserved.,"[70.0, 1277.0, 434.0, 1297.0]",footnote,0.7,"[""footnote label: 2214-7853\u00a9 2015 Elsevier Ltd. All rights reserved.""]",footnote,0.7,body_zone,body_like,none,True,True +1,19,footnote,Selection and Peer-review under responsibility of [Conference Committee Members of Recent Advances In Nano Science and Technology 2015].,"[70.0, 1295.0, 1005.0, 1338.0]",footnote,0.7,"[""footnote label: Selection and Peer-review under responsibility of [Conferenc""]",footnote,0.7,body_zone,body_like,none,True,True +2,0,number,2114,"[76.0, 93.0, 115.0, 111.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332.0, 93.0, 767.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,2,text,"of world human population, traffic accidents and musculoskeletal disorders have become common which in turn increased the demand for implants. The major problem related to such implants is the risk of","[72.0, 136.0, 1023.0, 875.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: of world human population, traffic accidents and musculoskel""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,3,paragraph_title,2. Materials and Method,"[74.0, 897.0, 295.0, 919.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Method""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +2,4,text,"Hydroxyapatite nanoparticles were synthesized by chemical method and all the regents used were of high purity grade. Briefly, 0.3M ortho-phosphoric acid (H₃PO₄, 85 %, purchased from Merck) was added d","[74.0, 943.0, 1018.0, 1058.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,Silver nanoparticles were synthesized by seed-growth method and the resultant particles were anisotropic in nature. All the chemicals were of high purity grade: Silver nitrate (AgNO₃) & dextrose (C₆H₁,"[72.0, 1059.0, 1022.0, 1314.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[339.0, 97.0, 776.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,2115,"[974.0, 97.0, 1012.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,(1:4) were added. The sample was allowed to react overnight and the color of final solution turned grey. The final sample was centrifuged at 6000 rpm and washed with ethanol to produce the silver inco,"[68.0, 139.0, 1013.0, 210.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,3. Results and Discussions,"[69.0, 222.0, 302.0, 244.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and Discussions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,4,text,Transmission electron microscopy (TEM) is an excellent tool for the investigation of topology and morphology of nanomaterials. The electron micrographs of the AgNPs incorporated hydroxyapatite is show,"[67.0, 257.0, 1014.0, 373.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,figure_title,Table 1. Calculated parameters from electron micrograph.,"[68.0, 391.0, 444.0, 412.0]",table_caption,0.9,"[""table prefix matched: Table 1. Calculated parameters from electron micrograph.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,6,table,
Figure NameMean Particle Size ( $ S_{m} $)Standard Deviation ( $ \sigma $)Average NPs Size= $ S_{m} \pm \sigma $Polyispersity= $ \sigma / S_{m} \time,"[61.0, 418.0, 989.0, 520.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,7,text,XRD pattern of hydroxyapatite with and without the incorporation of anisotropic AgNPs for the structural investigation is shown in the Figure.2. XRD pattern of HA and HA+Ag is well matched with the IC,"[68.0, 544.0, 1012.0, 637.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,display_formula, $$ \chi_{c}=\frac{\sum A_{c}}{\sum A_{c}+\sum A_{a}} $$ ,"[464.0, 634.0, 616.0, 686.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +3,9,text,Where $ \sum A_c $ and $ \sum A_a $ is the total area under the crystalline and amorphous phase in the pattern respectively which could be calculated by integrating the curve over the desired phase.,"[67.0, 685.0, 1013.0, 825.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,display_formula, $$ \frac{1}{\mathrm{d}^{2}}=\frac{4}{3}\left(\frac{\mathrm{h}^{2}+\mathrm{k}^{2}+\mathrm{hk}}{\mathrm{a}^{2}}\right)+\frac{\mathrm{l}^{2}}{\mathrm{c}^{2}} $$ ,"[416.0, 822.0, 666.0, 875.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +3,11,text,"Where a, b, c are the lattice parameters, h, k, and l are miller indices. The calculated crystal parameters are reported in the Table.2.","[67.0, 878.0, 1013.0, 924.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,figure_title,Table 2. Calculated lattice parameter from XRD pattern.,"[70.0, 943.0, 434.0, 964.0]",table_caption,0.9,"[""table prefix matched: Table 2. Calculated lattice parameter from XRD pattern.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,13,table,
Sample NameCrystallinity ( $ \chi_{c} $) %d (Ao)Crystal Size D (nm)a (nm)b (nm)c (nm)
HA862.806<,"[61.0, 970.0, 989.0, 1056.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,14,text,"The presence of high intense diffraction peaks at $ 2\square = 38.19 $, 44.37, 64.51, 77.45, and 81.60 confirmed the presence of AgNPs with 24.6 nm crystal size in the HA matrix [14]. The crystal siz","[67.0, 1082.0, 1010.0, 1151.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,text,"is the Bragg angle. The reduction in the crystal size in case of nanocomposite is due to the presence of AgNPs which inhibit the growth of HA matrix at some extent, but still the crystal structure is ","[67.0, 1153.0, 1015.0, 1307.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,2116,"[76.0, 93.0, 115.0, 111.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +4,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332.0, 92.0, 767.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +4,2,text," $ \chi_i's, = \left(\frac{k_i}{l_i}\sum_{i=1}^{n} \frac{l_i}{k_i}\right)^{-1} $, where $ n $ is the number of phases present in the mixture [15]. The sample HA contains hydroxyapatite single phase w","[72.0, 136.0, 1020.0, 269.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +4,3,chart,,"[203.0, 293.0, 577.0, 619.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,4,chart,,"[203.0, 639.0, 577.0, 933.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,5,image,,"[588.0, 290.0, 891.0, 593.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,6,image,,"[588.0, 604.0, 890.0, 905.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,7,chart,,"[206.0, 929.0, 581.0, 1239.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,8,image,,"[588.0, 910.0, 890.0, 1214.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,9,figure_title,Fig. 1. TEM images of Hydroxyapatite incorporated anisotropic AgNPs& corresponding size distribution histogram.,"[73.0, 1270.0, 824.0, 1292.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 1. TEM images of Hydroxyapatite incorporated anisotropi""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +5,0,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[340.0, 97.0, 776.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +5,1,number,2117,"[973.0, 97.0, 1012.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +5,2,chart,,"[198.0, 159.0, 897.0, 872.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +5,3,figure_title,Fig.2. XRD pattern of hydroxyapatite and silver-hydroxyapatite (HA+Ag) along with reference data card (Inset quantitative elemental analysis).,"[75.0, 895.0, 1006.0, 917.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.2. XRD pattern of hydroxyapatite and silver-hydroxyapati""]",figure_caption,0.85,tail_nonref_hold_zone,legend_like,none,False,False +5,4,chart,,"[250.0, 944.0, 814.0, 1272.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +5,5,figure_title,Fig.3. Fourier transform infrared spectroscopy (FTIR) spectra of HA and HA+Agnanocomposite.,"[69.0, 1282.0, 701.0, 1302.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.3. Fourier transform infrared spectroscopy (FTIR) spectr""]",figure_caption,0.85,tail_nonref_hold_zone,legend_like,none,False,False +6,0,number,2118,"[76.0, 92.0, 115.0, 111.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +6,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332.0, 92.0, 767.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +6,2,chart,,"[150.0, 151.0, 931.0, 677.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +6,3,chart,,"[150.0, 727.0, 928.0, 1238.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +6,4,figure_title,Fig.4. Thermogravimetric analysis (TGA) spectra of HA and HA+Agnanocomposite.,"[74.0, 1258.0, 629.0, 1280.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.4. Thermogravimetric analysis (TGA) spectra of HA and HA""]",figure_caption,0.85,tail_nonref_hold_zone,legend_like,none,False,False +7,0,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[339.0, 97.0, 776.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,2119,"[973.0, 97.0, 1013.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,The investigation of chemical structural composition of HA and HA+Ag was carried out by thermogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FTIR) also. The FTIR spectrum of H,"[66.0, 166.0, 1011.0, 383.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,image,,"[247.0, 401.0, 955.0, 502.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,4,figure_title,Fig.5. Proposed reaction mechanism of chemical synthesis of HA,"[68.0, 519.0, 498.0, 540.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.5. Proposed reaction mechanism of chemical synthesis of ""]",figure_caption,0.85,body_zone,legend_like,none,False,False +7,5,text,The 6.314% weight loss at 62.69 °C is attributed to the presence of water content in the sample which was confirmed by the absorption peak at 1631 cm⁻¹. The 10.76% weight loss corresponds to the PO₄ g,"[67.0, 564.0, 1011.0, 733.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,paragraph_title,4. Conclusion,"[69.0, 756.0, 193.0, 778.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Conclusion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,7,text,"In this study, structural characterization of hydroxyapatite with and without the incorporation of AgNPs has been investigated. Anisotropic AgNPs has been incorporated because of their enhanced antiba","[67.0, 804.0, 1014.0, 925.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,References,"[69.0, 996.0, 170.0, 1018.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +7,9,reference_content,"[1] T. Kim, J Periodontal Implant Sci. 44 (2014) 265-265.","[69.0, 1043.0, 449.0, 1062.0]",reference_item,0.85,"[""reference content label: [1] T. Kim, J Periodontal Implant Sci. 44 (2014) 265-265.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,10,reference_content,"[2] K. de Groot, ""Bioceramics Consisting of Calcium Phosphate Salts,"" Biomaterials. 1 (1900) 47-50.","[70.0, 1064.0, 727.0, 1083.0]",reference_item,0.85,"[""reference content label: [2] K. de Groot, \""Bioceramics Consisting of Calcium Phosphat""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,11,reference_content,"[3] F. Chenab, Y. Zhub, J. Wub, P. Huanga, D. Cuia, Nano Biomed. Eng. 4 (2012) 41-49.","[71.0, 1084.0, 652.0, 1103.0]",reference_item,0.85,"[""reference content label: [3] F. Chenab, Y. Zhub, J. Wub, P. Huanga, D. Cuia, Nano Bio""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,12,reference_content,"[4] N. Rameshbabu, T. S. S. Kumar, T.G. Prabhakar, V.S. Sastry, K.V.G.K. Murty, K. P. Rao, Journal of Biomedical Materials Research Part A. 80, (2007) 581-591.","[71.0, 1104.0, 1001.0, 1142.0]",reference_item,0.85,"[""reference content label: [4] N. Rameshbabu, T. S. S. Kumar, T.G. Prabhakar, V.S. Sast""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,13,reference_content,"[5] A. Bharti, S. Singh, V. K. Meena, and N. Goyal, Advanced Science Letters, 20 (2014) 1297–1302.","[70.0, 1143.0, 732.0, 1163.0]",reference_item,0.85,"[""reference content label: [5] A. Bharti, S. Singh, V. K. Meena, and N. Goyal, Advanced""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,14,reference_content,"[6] E. Ismail, M.B. Mohamed, A. Mostafa, H. Oudadesse, G. Kamal, Journal of Advances in Chemistry. 11 (2015) 3559-3566.","[71.0, 1163.0, 897.0, 1182.0]",reference_item,0.85,"[""reference content label: [6] E. Ismail, M.B. Mohamed, A. Mostafa, H. Oudadesse, G. Ka""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,15,reference_content,"[7] G. Liu, J. W. Talley, C. Na, S. L. Larson, L. G. Wolfe, Environ. Sci. Technol. (2009).","[70.0, 1183.0, 649.0, 1202.0]",reference_item,0.85,"[""reference content label: [7] G. Liu, J. W. Talley, C. Na, S. L. Larson, L. G. Wolfe, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,16,reference_content,"[8] S. Dasgupta, S. S. Banerjee, A. Bandyopadhyay, S. Bose, Langmuir, 26 (2010) 4958–4964.","[71.0, 1203.0, 685.0, 1221.0]",reference_item,0.85,"[""reference content label: [8] S. Dasgupta, S. S. Banerjee, A. Bandyopadhyay, S. Bose, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,17,reference_content,"[9] S. L. Iconaru, M. M. Heino, D. Predoi, Journal of Spectroscopy. (2013) 284285.","[70.0, 1222.0, 613.0, 1242.0]",reference_item,0.85,"[""reference content label: [9] S. L. Iconaru, M. M. Heino, D. Predoi, Journal of Spectr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,18,reference_content,"[10] N. Rameshbabu, T.S. Kumar, T.G. Prabhakar, K.P. Rao, Journal of Biomedical Materials Research Part A, (2006) 581-591.","[71.0, 1243.0, 897.0, 1262.0]",reference_item,0.85,"[""reference content label: [10] N. Rameshbabu, T.S. Kumar, T.G. Prabhakar, K.P. Rao, Jo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,19,reference_content,"[11] S. Pal, Y. K. Tak, and J. M. Song, Applied and Environmental Microbiology, (2007) 1712-1720.","[71.0, 1263.0, 728.0, 1282.0]",reference_item,0.85,"[""reference content label: [11] S. Pal, Y. K. Tak, and J. M. Song, Applied and Environm""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,20,reference_content,"[12] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater Electron, (2015).","[71.0, 1284.0, 561.0, 1303.0]",reference_item,0.85,"[""reference content label: [12] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater El""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,0,number,2120,"[77.0, 94.0, 115.0, 110.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +8,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332.0, 94.0, 767.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +8,2,reference_content,"[15] w. Chen, S. On, A. P. Ong, N. Oh, Y. Liu, H. S. Courtney, M. Appleford, J. L. Ong, Journal of Biomedical Materials Research Part A, (2006).","[78.0, 137.0, 977.0, 176.0]",reference_item,0.85,"[""reference content label: [15] w. Chen, S. On, A. P. Ong, N. Oh, Y. Liu, H. S. Courtne""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,3,reference_content,"[14] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater Electron, 25 (2014) 3747–3752.","[77.0, 178.0, 662.0, 194.0]",reference_item,0.85,"[""reference content label: [14] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater El""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,4,reference_content,"[15] F. H. Chung, J. Appl. Cryst. 8 (1975) 17-19.","[78.0, 198.0, 397.0, 215.0]",reference_item,0.85,"[""reference content label: [15] F. H. Chung, J. Appl. Cryst. 8 (1975) 17-19.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,5,reference_content,"[16] A. A. Shaltout, M. A. Allam, M. A. Moharram, Spectrochimica Acta Part A, 83 (2011) 56-60.","[78.0, 219.0, 715.0, 236.0]",reference_item,0.85,"[""reference content label: [16] A. A. Shaltout, M. A. Allam, M. A. 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Figure NameMean Particle Size ( $ S_{m} $)Stand", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:7", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "XRD pattern of hydroxyapatite with and without the incorporation of anisotropic ", + "found_in_fulltext": true, + "fulltext_offset": 3382 + }, + { + "block_id": "p3:8", + "page": 3, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ \\chi_{c}=\\frac{\\sum A_{c}}{\\sum A_{c}+\\sum A_{a}} $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:9", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Where $ \\sum A_c $ and $ \\sum A_a $ is the total area under the crystalline and ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:10", + "page": 3, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ \\frac{1}{\\mathrm{d}^{2}}=\\frac{4}{3}\\left(\\frac{\\mathrm{h}^{2}+\\mathrm{k}^{2}", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:11", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Where a, b, c are the lattice parameters, h, k, and l are miller indices. 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"sha256:4b64f4b8e4d0434b8109b17b4609df7fa3b799c59ef61e4267aac1c0f90779b9" + } + }, + "artifact_freshness": { + "missing": [], + "mismatches": [ + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" + ], + "annotated_pages_rendered": [ + "page_001.png", + "page_002.png", + "page_003.png", + "page_004.png", + "page_005.png", + "page_006.png", + "page_007.png", + "page_008.png", + "page_009.png" + ] + }, + "reviewed_pages": [ + 1, + 2, + 3, + 4, + 5, + 6, + 7, + 8 + ], + "reviewed_blocks": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:8", + "p2:9", + "p2:10", + "p2:11", + "p2:12", + "p2:13", + "p2:14", + "p2:15", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:4", + "p3:5", + "p3:6", + "p3:7", + "p3:8", + "p3:9", + "p3:10", + "p3:11", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p4:10", + "p4:11", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p5:11", + "p5:12", + "p6:0", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p6:5", + "p6:6", + "p6:7", + "p6:8", + "p6:9", + "p6:10", + "p6:11", + "p7:0", + "p7:1", + "p7:2", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p7:12", + "p7:13", + "p7:14", + "p7:15", + "p7:16", + "p7:17", + "p7:18", + "p7:19", + "p8:0", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p8:9", + "p8:10", + "p8:11", + "p8:12", + "p8:13", + "p8:14", + "p8:15", + "p8:16", + "p8:17", + "p8:18", + "p8:19", + "p8:20", + "p8:21", + "p8:22", + "p8:23", + "p8:24", + "p8:25", + "p8:26", + "p8:27", + "p8:28", + "p8:29" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:11", + "p1:13", + "p1:14", + "p1:16", + "p1:17", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p2:10", + "p2:12", + "p3:0", + "p3:1", + "p3:2" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/4KCHGV2Z/audit_report.md b/audit/4KCHGV2Z/audit_report.md new file mode 100644 index 00000000..3e251330 --- /dev/null +++ b/audit/4KCHGV2Z/audit_report.md @@ -0,0 +1,38 @@ +# OCR Truth Audit Report - 4KCHGV2Z + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 3, 4, 5, 6, 7, 8] +- Reviewed blocks: 134 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/4KCHGV2Z/audit_scope.json b/audit/4KCHGV2Z/audit_scope.json new file mode 100644 index 00000000..a1f33f0e --- /dev/null +++ b/audit/4KCHGV2Z/audit_scope.json @@ -0,0 +1,1399 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 3, + 4, + 5, + 6, + 7, + 8 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p2:11", + "p2:12", + "p2:13", + "p2:15", + "p3:10", + "p3:11", + "p4:4", + "p4:11", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:12", + "p6:4", + "p6:5", + "p6:6", + "p6:7", + "p6:11", + "p7:0", + "p7:1", + "p7:2", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p7:12", + "p7:13", + "p7:14", + "p7:15", + "p7:16", + "p7:17", + "p7:18", + "p7:19", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p8:9", + "p8:10", + "p8:11", + "p8:12", + "p8:13", + "p8:14", + "p8:15", + "p8:16", + "p8:17", + "p8:18", + "p8:19", + "p8:20", + "p8:21", + "p8:22", + "p8:23", + "p8:24", + "p8:25", + "p8:26", + "p8:27", + "p8:28", + "p8:29" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], 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Heel-type Spur and Rotator Cuff Tear""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"Joo Han Oh MD, PhD, Jae Yoon Kim MD, Ho Kyoo Lee MD, Jung-Ah Choi MD, PhD","[95.0, 360.0, 486.0, 412.0]",authors,0.8,"[""page-1 zone author_zone: Joo Han Oh MD, PhD, Jae Yoon Kim MD, Ho Kyoo Lee MD, Jung-Ah""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,Received: 12 February 2009 / Accepted: 10 August 2009 / Published online: 4 September 2009,"[96.0, 485.0, 761.0, 507.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 12 February 2009 / Accepted: 10 August 2009 / Publ""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,6,text,© The Association of Bone and Joint Surgeons $ ^{\textregistered} $ 2009,"[97.0, 506.0, 494.0, 528.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 The Association of Bone and Joint Surgeons $ ^{\\textregist""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,7,abstract,Abstract Acromial spurs reportedly relate to the impingement syndrome and rotator cuff tears. We classified the morphologic characteristics of the acromion (shape and thickness) and acromial spurs and,"[96.0, 563.0, 583.0, 888.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,8,abstract,group. The heel type was most common and detected in 59 patients (56%) in the cuff tear group and in 36 patients (35%) in the control group. The flat acromion was more common (60%) than curved and hoo,"[604.0, 563.0, 1094.0, 834.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,9,text,"Level of Evidence: Level IV, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.","[606.0, 836.0, 1093.0, 911.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,10,footnote,"Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in ","[97.0, 932.0, 582.0, 1012.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Each author certifies that he or she has no commercial assoc""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,paragraph_title,Introduction,"[607.0, 962.0, 725.0, 986.0]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,12,footnote,Each author certifies that his or her institution has approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research. T,"[97.0, 1013.0, 580.0, 1115.0]",footnote,0.7,"[""footnote label: Each author certifies that his or her institution has approv""]",footnote,0.7,body_zone,body_like,none,True,True +1,13,text,"Rotator cuff disorder is a common cause of chronic shoulder pain in adults. The specific etiology of a rotator cuff tear has not been fully elucidated, but it has been considered to result from a comb","[605.0, 1011.0, 1093.0, 1236.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,footnote,"J. H. Oh, H. K. Lee +Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Korea","[96.0, 1131.0, 538.0, 1217.0]",footnote,0.7,"[""footnote label: J. H. Oh, H. K. Lee\nDepartment of Orthopedic Surgery, Seoul ""]",footnote,0.7,body_zone,body_like,none,True,True +1,15,footnote,"J. Y. Kim (✉) +Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, 224-1, Heukseok-Dong, Dongjak-ku, Seoul 156-755, Korea +e-mail: orthozan@hanmail.net","[95.0, 1232.0, 523.0, 1335.0]",footnote,0.7,"[""footnote label: J. Y. Kim (\u2709)\nDepartment of Orthopaedic Surgery, Chung-Ang U""]",footnote,0.7,body_zone,body_like,none,True,True +1,16,footnote,"J.-A. Choi +Department of Radiology, Seoul National University College +of Medicine, Seoul National University Bundang Hospital, +Seoul, Korea","[96.0, 1352.0, 532.0, 1434.0]",footnote,0.7,"[""footnote label: J.-A. Choi\nDepartment of Radiology, Seoul National Universit""]",footnote,0.7,body_zone,body_like,none,True,True +1,17,text,"The coracoacromial ligament [9, 10, 20], shape of the acromion [2, 3, 25], and formation of acromial spurs [21, 26] reportedly relate to impingement and their association with rotator cuff tears has b","[605.0, 1236.0, 1094.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,18,footer_image,,"[99.0, 1470.0, 187.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,0,header,"Volume 468, Number 6, June 2010","[98.0, 65.0, 352.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,Heel-type Spur and Rotator Cuff Tear,"[762.0, 65.0, 1035.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,number,1543,"[1053.0, 65.0, 1091.0, 84.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,3,text,"enlarge the subacromial space and decompress the rotator cuff. Numerous subsequent studies [2, 3, 8, 17, 21, 25, 26] have supported Neer's theory of extrinsic impingement leading to cuff disease and c","[95.0, 115.0, 583.0, 239.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,Various relationships reportedly occur between acromial spurs and rotator cuff tear. Ogawa et al. [21] classified acromial spurs according to size and emphasized only large spurs measuring 5 mm or gre,"[96.0, 239.0, 583.0, 736.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Therefore, the purposes of our study were (1) to classify the morphologic characteristics of acromial spurs in rotator cuff disorder; and (2) to evaluate the clinical correlation of acromial character","[95.0, 738.0, 583.0, 863.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,paragraph_title,Materials and Methods,"[97.0, 913.0, 308.0, 935.0]",section_heading,0.9,"[""explicit scholarly heading: Materials and Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,7,text,We retrospectively reviewed the prospectively collected data from all 106 patients with full-thickness rotator cuff tears who underwent rotator cuff repair surgery between July 2007 and September 2008,"[95.0, 961.0, 584.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,text,"shoulders, fractures, and tumors. There were 54 men and +48 women with an average age of 57.5 years (range, 45– +79 years) in the control group. We observed no difference +in age and gender ratio between","[605.0, 116.0, 1093.0, 214.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"We evaluated plain radiographs, including shoulder true AP, lateral, axial, supraspinatus outlet, and 30° caudal tilt view; MRA or CTA also was performed in all patients. Acromial thickness, shape, an","[604.0, 215.0, 1094.0, 614.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,figure_title,Table 1. Demographic data for both patient groups,"[607.0, 650.0, 979.0, 671.0]",table_caption,0.9,"[""table prefix matched: Table 1. Demographic data for both patient groups""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +2,11,table,"
Demographic characteristicsRotator cuff tear group (n = 106)Control group (n = 102)
Mean age (years)59.6 (range, 49-78)57.5 (range, ","[607.0, 675.0, 1090.0, 793.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +2,12,inline_formula, $$ p>0.05. $$ ,"[609.0, 799.0, 678.0, 821.0]",unknown_structural,0.2,"[""unrecognized label 'inline_formula'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,short_fragment,False,True +2,13,image,,"[616.0, 869.0, 1083.0, 1331.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,14,figure_title,Fig. 1 Acromial thickness was measured at the widest portion of the acromion on the perpendicular plane to the long axis of the acromion on the oblique sagittal image plane just lateral to the acromio,"[606.0, 1354.0, 1093.0, 1434.0]",figure_caption,0.92,"[""figure_title label: Fig. 1 Acromial thickness was measured at the widest portion""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,15,footer_image,,"[1004.0, 1470.0, 1091.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,0,number,1544,"[100.0, 65.0, 139.0, 84.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,Oh et al.,"[156.0, 65.0, 222.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,header,Clinical Orthopaedics and Related Research $ ^{®} $,"[764.0, 64.0, 1090.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,3,text,"interobserver reliability, acromial spur types were redetermined independently by two orthopaedic surgeons (HKL, SKL) after the classification scheme of acromial spurs was explained to them. The kappa","[95.0, 116.0, 583.0, 289.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,"We used Student's t-test to compare continuous variables (age, acromial thickness, and tear size) between the two groups. The chi square test was used to evaluate discrete variables (gender, acromial ","[95.0, 290.0, 583.0, 489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Results,"[97.0, 538.0, 169.0, 561.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,6,text,"We observed distinct morphologic types of acromial spurs and categorized them into heel, lateral/anterior traction, lateral/anterior bird beak, and medial types. The quadrangular spur protruded inferi","[95.0, 588.0, 583.0, 713.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"type spur (Fig. 2). Laterally protruding spurs were seen +with the lateral traction and lateral bird beak-type spurs in +the coronal plane. The lateral traction-type spur was con- +gruent with the acromi","[604.0, 117.0, 1094.0, 487.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"We detected acromial spurs in 142 of the 208 patients (68%), and their incidence increased with age. The acromial spurs were detected more frequently (p = 0.006) in patients older than 65 years (80%) ","[604.0, 488.0, 1094.0, 714.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,figure_title,Fig. 2A–D (A) The inferior bony projection that looks like the heel of a shoe is shown in this diagram. This kind of spur was categorized as a heel-type spur. The heel-type spur can be seen on the (B),"[96.0, 754.0, 340.0, 939.0]",figure_caption,0.92,"[""figure_title label: Fig. 2A\u2013D (A) The inferior bony projection that looks like t""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,10,image,,"[365.0, 760.0, 1090.0, 1431.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,11,footer_image,,"[98.0, 1470.0, 187.0, 1498.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +4,0,header,"Volume 468, Number 6, June 2010","[98.0, 65.0, 352.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header,Heel-type Spur and Rotator Cuff Tear,"[762.0, 65.0, 1034.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,number,1545,"[1053.0, 66.0, 1091.0, 83.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,figure_title,Fig. 3A–B (A) The acromial spur is located at the lateral end of the acromion and is congruent with the acromial undersurface or parallel to the direction of the rotator cuff. This kind of spur was ca,"[96.0, 112.0, 339.0, 295.0]",figure_caption,0.92,"[""figure_title label: Fig. 3A\u2013B (A) The acromial spur is located at the lateral en""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,4,image,,"[102.0, 113.0, 1087.0, 828.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,5,figure_title,Fig. 4A–C (A) The acromial spur is located at the lateral end of the acromion. It is not congruent with the acromial undersurface or the rotator cuff. This spur was categorized as a bird beak spur and,"[96.0, 848.0, 1090.0, 890.0]",figure_caption,0.92,"[""figure_title label: Fig. 4A\u2013C (A) The acromial spur is located at the lateral en""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,6,text,"subjects [58%] (Table 2). Spurs were more frequent (p = 0.002) in patients with full-thickness cuff tears than in the control group. However, they were not related (p = 0.700, 0.248, respectively) wit","[95.0, 938.0, 583.0, 1210.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"One hundred twenty-five patients (60%) had a flat-type acromion, 60 (28%) had the curved type, and 23 (11%) had the hooked type. There were no differences (p = 0.124) in the distribution of each acrom","[95.0, 1212.0, 583.0, 1436.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"thicker (p = 0.014) than those in the control group +(Table 4). Acromions were thicker in men than in women +although the two-way ANOVA showed gender was not a +confounding factor because there was no in","[604.0, 938.0, 1094.0, 1061.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,Discussion,"[608.0, 1111.0, 706.0, 1134.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,10,text,"Acromial spurs apparently form by traction of the coracoacromial ligament and reportedly are related to rotator cuff tears [5, 9, 20, 21, 26], although it is debatable whether it is the cause of a rot","[604.0, 1161.0, 1094.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,footer_image,,"[1003.0, 1471.0, 1091.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,0,number,1546,"[101.0, 66.0, 139.0, 84.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,Oh et al.,"[157.0, 66.0, 222.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,header,Clinical Orthopaedics and Related Research $ ^{®} $,"[765.0, 64.0, 1088.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,3,figure_title,Fig. 5A–D (A) This diagram illustrates the spur located at the medial end of the acromion or distal end of the clavicle. It was categorized as a medial-type spur and can be seen on a (B) simple radiog,"[97.0, 113.0, 340.0, 276.0]",figure_caption,0.92,"[""figure_title label: Fig. 5A\u2013D (A) This diagram illustrates the spur located at t""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,image,,"[367.0, 118.0, 728.0, 467.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,image,,"[737.0, 120.0, 1089.0, 405.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,image,,"[366.0, 476.0, 730.0, 764.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,7,image,,"[737.0, 414.0, 1089.0, 762.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,text,acromial spurs and rotator cuff tears. This could provide useful guidance regarding the diagnosis and treatment of rotator cuff tears.,"[95.0, 811.0, 583.0, 885.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,9,text,"There are certain limitations to our study. First, spur classification by morphology is somewhat subjective, although interobserver and intraobserver reliability were 0.766/0.734 in the coronal plane ","[95.0, 888.0, 584.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"substantial number of patients, including a healthy popu- +lation, would be needed to completely confirm the +relationship between acromial spurs and rotator cuff tears. +Finally, there were 59 patients w","[604.0, 811.0, 1094.0, 1310.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,Ogawa et al. [21] classified acromial spurs according to size and emphasized only large spurs measuring 5 mm or greater are of diagnostic value because of the high rate of association with the bursal-,"[604.0, 1310.0, 1095.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,footer_image,,"[99.0, 1471.0, 187.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +6,0,header,"Volume 468, Number 6, June 2010","[98.0, 65.0, 351.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header,Heel-type Spur and Rotator Cuff Tear,"[763.0, 65.0, 1034.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,2,number,1547,"[1053.0, 66.0, 1091.0, 84.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,3,figure_title,"Fig. 6A–D (A) The diagram illustrates the anterior bony projection along with the coracoacromial ligament and the spur, which is congruent with the acromial undersurface or parallel to the rotator cuf","[97.0, 113.0, 340.0, 395.0]",figure_caption,0.92,"[""figure_title label: Fig. 6A\u2013D (A) The diagram illustrates the anterior bony proj""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,4,image,,"[366.0, 122.0, 610.0, 469.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,image,,"[621.0, 119.0, 1089.0, 464.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,6,image,,"[367.0, 474.0, 731.0, 823.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,7,image,,"[736.0, 474.0, 1090.0, 822.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,text,"morphologic characteristics, because we noticed some acromial spurs share their typical shape. The mechanisms of each type of spur formation are unclear, but we presumed traction spurs were formed by ","[96.0, 885.0, 584.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"tears. However, we observed an association of full-thick- +ness rotator cuff tears and the heel-type acromial spur. +Patients with partial rotator cuff tears and heel-type spurs +seen on MRI or with heel","[605.0, 884.0, 1093.0, 1057.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"There are numerous theories regarding the causative factors of rotator cuff tears, and none fully explain the etiology. Acromial spurs are a potential causative factor of rotator cuff tears. However, ","[604.0, 1059.0, 1095.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,footer_image,,"[1004.0, 1471.0, 1091.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +7,0,number,1548,"[101.0, 65.0, 139.0, 84.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +7,1,header,Oh et al.,"[157.0, 66.0, 222.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +7,2,header,Clinical Orthopaedics and Related Research $ ^{®} $,"[766.0, 64.0, 1088.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +7,3,text,Fig. 7A–D (A) The anteroinferior bony projection has the appearance of a bird beak. It is neither congruent with the acromial undersurface nor parallel to the rotator cuff. This type of spur was categ,"[96.0, 113.0, 339.0, 375.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Fig. 7A\u2013D (A) The anteroinferior bony projection has the app""]",figure_caption_candidate,0.9,tail_nonref_hold_zone,legend_like,figure_number,True,True +7,4,image,,"[365.0, 114.0, 682.0, 488.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,5,image,,"[700.0, 118.0, 1090.0, 389.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,6,figure_title,B,"[707.0, 369.0, 727.0, 391.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +7,7,image,,"[367.0, 504.0, 696.0, 782.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,8,image,,"[700.0, 401.0, 1090.0, 782.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,9,chart,,"[103.0, 815.0, 575.0, 1121.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,10,figure_title,Fig. 8 The incidence of acromial spurs increased with advancing age. Patients younger than 55 years had a lower incidence of spurs than older patients. There was no major difference between the 55- to,"[96.0, 1137.0, 582.0, 1221.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 8 The incidence of acromial spurs increased with advanc""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +7,11,text,"Since Neer [15, 16] reported the impingement theory and rotator cuff tears, numerous studies [2, 3, 8, 12, 17, 21, 23, 25, 26] have elucidated the details of the association","[96.0, 1361.0, 582.0, 1434.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,12,text,"than 5 mm were associated with rotator cuff tears. Our data suggest the incidence of acromial spurs increases with age, and acromial spurs, especially the heel type, are more frequent in patients with","[95.0, 1261.0, 582.0, 1359.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,13,figure_title,Table 2. Relationship between the type of acromial spur and rotator cuff tear,"[606.0, 822.0, 1091.0, 865.0]",table_caption,0.9,"[""table prefix matched: Table 2. Relationship between the type of acromial spur and ""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +7,14,table,
Classification of acromial spursRotator cuff tear group (n = 106)Control group (n = 102)Total (n = 208)
Acromial spur83 $ ^{*} $ (78,"[607.0, 860.0, 1092.0, 1161.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +7,15,vision_footnote, $ ^{*} $ Significant difference between the two groups (p < 0.05).,"[608.0, 1169.0, 1030.0, 1191.0]",footnote,0.7,"[""vision_footnote label: $ ^{*} $ Significant difference between the two groups (p < ""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,affiliation_marker,True,True +7,16,figure_title,Table 3. Size of full-thickness rotator cuff tears according to the acromial spur,"[606.0, 1240.0, 1091.0, 1282.0]",table_caption,0.9,"[""table prefix matched: Table 3. Size of full-thickness rotator cuff tears according""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +7,17,table,
Index groupAnteroposterior dimension (cm)Retraction (cm)
Acromial spur (+) (n = 83)2.242.27
Acromial spur (−) (n = ,"[606.0, 1289.0, 1090.0, 1406.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +7,18,inline_formula, $$ p>0.05. $$ ,"[608.0, 1409.0, 679.0, 1432.0]",unknown_structural,0.2,"[""unrecognized label 'inline_formula'""]",unknown_structural,0.2,tail_nonref_hold_zone,unknown_like,short_fragment,False,True +7,19,footer_image,,"[98.0, 1470.0, 187.0, 1497.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,tail_nonref_hold_zone,unknown_like,empty,False,True +8,0,header,"Volume 468, Number 6, June 2010","[98.0, 65.0, 352.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header,Heel-type Spur and Rotator Cuff Tear,"[762.0, 65.0, 1035.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,2,number,1549,"[1053.0, 66.0, 1091.0, 84.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,3,figure_title,"Table 4. Relationship among acromial thickness, shape, and full-thickness rotator cuff tear","[97.0, 117.0, 581.0, 157.0]",table_caption,0.9,"[""table prefix matched: Table 4. Relationship among acromial thickness, shape, and f""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +8,4,table,"
Morphologic characteristics of acromionRotator cuff tear group (n = 106)Control group (n = 102)Total (n = 208)
Acromial shape0.05. $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:0", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "1544", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:1", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Oh et al.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:2", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Clinical Orthopaedics and Related Research $ ^{®} $", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:3", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "interobserver reliability, acromial spur types were redetermined independently b", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:4", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "We used Student's t-test to compare continuous variables (age, acromial thicknes", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:5", + "page": 3, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Results", + "found_in_fulltext": true, + "fulltext_offset": 5070 + }, + { + "block_id": "p3:6", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "We observed distinct morphologic types of acromial spurs and categorized them in", + "found_in_fulltext": true, + "fulltext_offset": 5078 + }, + { + "block_id": "p3:7", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "type spur (Fig. 2). Laterally protruding spurs were seen with the lateral tracti", + "found_in_fulltext": true, + "fulltext_offset": 5371 + }, + { + "block_id": "p3:8", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "We detected acromial spurs in 142 of the 208 patients (68%), and their incidence", + "found_in_fulltext": true, + "fulltext_offset": 7087 + }, + { + "block_id": "p4:0", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Volume 468, Number 6, June 2010", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:1", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Heel-type Spur and Rotator Cuff Tear", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:2", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "1545", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:6", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "subjects [58%] (Table 2). Spurs were more frequent (p = 0.002) in patients with ", + "found_in_fulltext": true, + "fulltext_offset": 7916 + }, + { + "block_id": "p4:7", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "One hundred twenty-five patients (60%) had a flat-type acromion, 60 (28%) had th", + "found_in_fulltext": true, + "fulltext_offset": 8508 + }, + { + "block_id": "p4:8", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "thicker (p = 0.014) than those in the control group (Table 4). Acromions were th", + "found_in_fulltext": true, + "fulltext_offset": 9009 + }, + { + "block_id": "p4:9", + "page": 4, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Discussion", + "found_in_fulltext": true, + "fulltext_offset": 9488 + }, + { + "block_id": "p4:10", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Acromial spurs apparently form by traction of the coracoacromial ligament and re", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:0", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "1546", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:1", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Oh et al.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:2", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Clinical Orthopaedics and Related Research $ ^{®} $", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:8", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "acromial spurs and rotator cuff tears. This could provide useful guidance regard", + "found_in_fulltext": true, + "fulltext_offset": 9825 + }, + { + "block_id": "p5:9", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "There are certain limitations to our study. First, spur classification by morpho", + "found_in_fulltext": true, + "fulltext_offset": 9960 + }, + { + "block_id": "p5:10", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "substantial number of patients, including a healthy popu- lation, would be neede", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:11", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Ogawa et al. [21] classified acromial spurs according to size and emphasized onl", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:0", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Volume 468, Number 6, June 2010", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:1", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Heel-type Spur and Rotator Cuff Tear", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:2", + "page": 6, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "1547", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:8", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "morphologic characteristics, because we noticed some acromial spurs share their ", + "found_in_fulltext": true, + "fulltext_offset": 12383 + }, + { + "block_id": "p6:9", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "tears. However, we observed an association of full-thick- ness rotator cuff tear", + "found_in_fulltext": true, + "fulltext_offset": 14007 + }, + { + "block_id": "p6:10", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "There are numerous theories regarding the causative factors of rotator cuff tear", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:0", + "page": 7, + "role": "noise", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "1548", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:1", + "page": 7, + "role": "noise", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "Oh et al.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:2", + "page": 7, + "role": "noise", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "Clinical Orthopaedics and Related Research $ ^{®} $", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:3", + "page": 7, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Fig. 7A–D (A) The anteroinferior bony projection has the appearance of a bird be", + "found_in_fulltext": true, + "fulltext_offset": 14856 + }, + { + "block_id": "p7:10", + "page": 7, + "role": "figure_caption_candidate", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "Fig. 8 The incidence of acromial spurs increased with advancing age. Patients yo", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:11", + "page": 7, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Since Neer [15, 16] reported the impingement theory and rotator cuff tears, nume", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:12", + "page": 7, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "than 5 mm were associated with rotator cuff tears. Our data suggest the incidenc", + "found_in_fulltext": true, + "fulltext_offset": 14441 + }, + { + "block_id": "p7:13", + "page": 7, + "role": "table_caption", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Table 2. Relationship between the type of acromial spur and rotator cuff tear", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:15", + "page": 7, + "role": "footnote", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "$ ^{*} $ Significant difference between the two groups (p < 0.05).", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:16", + "page": 7, + "role": "table_caption", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Table 3. Size of full-thickness rotator cuff tears according to the acromial spu", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:18", + "page": 7, + "role": "unknown_structural", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "$$ p>0.05. $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:0", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Volume 468, Number 6, June 2010", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:1", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Heel-type Spur and Rotator Cuff Tear", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:2", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "1549", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:3", + "page": 8, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 4. Relationship among acromial thickness, shape, and full-thickness rotato", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:5", + "page": 8, + "role": "footnote", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "$ ^{*} $ Significant difference between the two groups (p < 0.05).", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:6", + "page": 8, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "between the acromial shape and rotator cuff disease. These authors emphasized th", + "found_in_fulltext": true, + "fulltext_offset": 15337 + }, + { + "block_id": "p8:7", + "page": 8, + "role": "backmatter_body", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Morphologic features of acromial spurs can be classified as heel, lateral/anteri", + "found_in_fulltext": true, + "fulltext_offset": 19322 + }, + { + "block_id": "p8:8", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Acknowledgments We thank Ki Hyun Jo, MD, Suk Jae Lee, MD, Hye Ran Kim, and Sang ", + "found_in_fulltext": true, + "fulltext_offset": 17010 + }, + { + "block_id": "p8:9", + "page": 8, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": true, + "fulltext_offset": 17384 + }, + { + "block_id": "p8:10", + "page": 8, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "1. 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"mismatches": [ + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" + ], + "annotated_pages_rendered": [ + "page_001.png", + "page_002.png", + "page_003.png", + "page_004.png", + "page_005.png", + "page_006.png", + "page_007.png", + "page_008.png", + "page_009.png" + ] + }, + "reviewed_pages": [ + 1, + 2, + 4, + 5, + 6, + 7, + 8 + ], + "reviewed_blocks": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:8", + "p2:9", + "p2:10", + "p2:11", + "p2:12", + "p2:13", + "p2:14", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p6:0", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p7:0", + "p7:1", + "p7:2", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p8:0", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p8:9", + "p8:10", + "p8:11", + "p8:12", + "p8:13", + "p8:14", + "p8:15", + "p8:16", + "p8:17", + "p8:18", + "p8:19", + "p8:20", + "p8:21", + "p8:22", + "p8:23", + "p8:24", + "p8:25" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:5", + "p2:0", + "p2:5", + "p3:0", + "p3:1", + "p3:2", + "p3:5", + "p3:13", + "p4:0", + "p4:1", + "p4:5", + "p5:0", + "p5:1", + "p5:4", + "p5:5", + "p5:8" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/4M3K4W7C/audit_report.md b/audit/4M3K4W7C/audit_report.md new file mode 100644 index 00000000..acf8b671 --- /dev/null +++ b/audit/4M3K4W7C/audit_report.md @@ -0,0 +1,36 @@ +# OCR Truth Audit Report - 4M3K4W7C + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 4, 5, 6, 7, 8] +- Reviewed blocks: 100 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/4M3K4W7C/audit_scope.json b/audit/4M3K4W7C/audit_scope.json new file mode 100644 index 00000000..10a9b64e --- /dev/null +++ b/audit/4M3K4W7C/audit_scope.json @@ -0,0 +1,1163 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 4, + 5, + 6, + 7, + 8 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p2:1", + "p2:2", + "p2:3", + "p4:2", + "p5:2", + "p5:8", + "p6:0", + "p6:1", + "p6:2", + "p6:3", + "p6:4", + "p7:0", + "p7:1", + "p7:2", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p8:9", + "p8:10", + "p8:11", + "p8:12", + "p8:13", + "p8:14", + "p8:15", + "p8:16", + "p8:17", + "p8:18", + "p8:19", + "p8:20", + "p8:21", + "p8:22", + "p8:23", + "p8:24", + "p8:25" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:9", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:10", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:11", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:12", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { 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Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial Impingement Syndrome. Orthopedic Reviews. 2025;17. doi:10.52965/001c.141407,"[591.0, 28.0, 1082.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,reference_like,citation_line,False,False +1,1,text,General,"[104.0, 109.0, 182.0, 136.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True +1,2,doc_title,Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial Impingement Syndrome,"[103.0, 146.0, 924.0, 264.0]",paper_title,0.8,"[""page-1 zone title_zone: Acromion Shape and Degenerative Changes of the Acromioclavic""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,Rani Ahmad $ ^{1} $,"[104.0, 273.0, 218.0, 297.0]",authors,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,True,True +1,4,text,"1 Radiology Department, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia +Keywords: Subacromial impingement syndrome (SAIS), shoulder, tendinopathy, supraspinatus +htt","[102.0, 304.0, 809.0, 381.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: 1 Radiology Department, King Abdulaziz University Hospital, ""]",frontmatter_noise,0.8,body_zone,reference_like,reference_numeric_dot,False,False +1,5,text,"Orthopedic Reviews +Vol. 17, 2025","[104.0, 406.0, 325.0, 467.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,6,paragraph_title,Background,"[231.0, 501.0, 362.0, 528.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Background""]",section_heading,0.5,body_zone,heading_like,short_fragment,True,True +1,7,abstract,"The widespread condition Subacromial impingement syndrome (SAIS) appears among the leading causes of shoulder pain, which restrict people in their daily routine activities and diminish their quality o","[231.0, 536.0, 951.0, 636.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,8,paragraph_title,Objective,"[232.0, 648.0, 337.0, 676.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Objective""]",section_heading,0.5,body_zone,heading_like,short_fragment,True,True +1,9,abstract,The study aims to determine whether particular acromion shapes and different stages of AC joint degeneration significantly contribute to the risk of developing SAIS.,"[231.0, 682.0, 948.0, 734.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,10,paragraph_title,Methods,"[231.0, 747.0, 330.0, 772.0]",section_heading,0.9,"[""explicit scholarly heading: Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,11,abstract,The retrospective study was conducted on 608 patients who underwent shoulder MRI between the period of 2017 to 2020. The Acromion type and AC joint degeneration severity were evaluated by using T1- or,"[229.0, 780.0, 933.0, 881.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,12,paragraph_title,Results,"[231.0, 894.0, 316.0, 920.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,13,abstract,"Type III acromion and mild AC joint degeneration were more frequently observed in SAIS patients, but these findings were not statistically significant (P-value =0.38). Results showed that supraspinatu","[228.0, 927.0, 957.0, 1028.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,14,paragraph_title,Conclusion,"[231.0, 1040.0, 355.0, 1066.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,15,abstract,"Acromion shape together with AC joint degeneration did not produce significant effects on increasing the risk of developing SAIS. However, the rotator cuff pathologies combined with reduced subacromia","[228.0, 1074.0, 940.0, 1174.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,16,paragraph_title,INTRODUCTION,"[104.0, 1200.0, 267.0, 1225.0]",section_heading,0.9,"[""explicit scholarly heading: INTRODUCTION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,17,text,The most prevalent cause of shoulder pain is subacromial impingement syndrome (SAIS). The pain and dysfunction in the shoulder joint are the primary symptoms of this syndrome. $ ^{1} $ SAIS represente,"[102.0, 1253.0, 586.0, 1473.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,18,text,The acromiohumeral distance measures the space between the humeral head and the acromion. This measurement is typically used to assess the size of the subacromial space and can be obtained through var,"[102.0, 1474.0, 587.0, 1574.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,19,text,"niques, including MRI, ultrasound, CT scans, and radi­ +ographs.4 During MRI analysis, several anatomical struc­ +tures within the subacromial space are identified. These +include the subacromial bursa, ","[600.0, 1197.0, 1088.0, 1442.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,text,"In most studies, two methods are commonly used for the classification of acromion shapes. In the first method, acromion types consist of the superior perspective that has been demonstrated: cobra (Typ","[601.0, 1443.0, 1088.0, 1567.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,0,header,Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial...,"[250.0, 45.0, 937.0, 65.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,1,image,,"[199.0, 131.0, 994.0, 409.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,2,image,,"[592.0, 131.0, 792.0, 407.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,3,image,,"[805.0, 132.0, 993.0, 406.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,4,figure_title,Figure 1. Types of Acromion Shape,"[104.0, 431.0, 413.0, 455.0]",figure_caption,0.92,"[""figure_title label: Figure 1. Types of Acromion Shape""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,5,text,"method consists of the underlying perspective and tendency of the acromion described as types as Type I (flat inferior surface), Type II (curved inferior surface), and Type III (hooked inferior surfac","[102.0, 489.0, 587.0, 782.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,Another disorder rotator cuff tear (RCT) is described by a debilitated shoulder and pain. RCT is a disorder characterized by shoulder dysfunction and pain. The occurrence of RCT in the generic populat,"[102.0, 784.0, 588.0, 1570.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"don, but without tendon retraction or abnormal intramus­ +cular signal; Type III impingement encompasses abnormal +signal intensity with muscle retraction, representing full- +thickness tears. There are ","[601.0, 489.0, 1088.0, 1078.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,MATERIALS AND METHODS STUDY DESIGN AND SETTING,"[603.0, 1107.0, 880.0, 1184.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: MATERIALS AND METHODS STUDY DESIGN AND SETTING""]",section_heading,0.6,body_zone,heading_like,none,True,True +2,9,footer,,"[603.0, 1160.0, 856.0, 1184.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,10,text,"This retrospective study was conducted at King Abdul Aziz University Hospital in Jeddah, Saudi Arabia. The data was collected from shoulder MRI scans obtained between 2017 and 2020.","[601.0, 1206.0, 1087.0, 1302.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,paragraph_title,INCLUSION AND EXCLUSION CRITERIA,"[603.0, 1326.0, 934.0, 1349.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: INCLUSION AND EXCLUSION CRITERIA""]",section_heading,0.6,body_zone,heading_like,none,True,True +2,12,text,Patients aged 18 years or older with clinical uncertainty or a confirmed diagnosis of SAIS were included in the study. Medical professionals evaluated clinical symptoms of SAIS by examining reduced sh,"[601.0, 1372.0, 1088.0, 1570.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,footer,Orthopedic Reviews,"[534.0, 1621.0, 656.0, 1639.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,14,number,2,"[1068.0, 1619.0, 1085.0, 1641.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial...,"[249.0, 44.0, 938.0, 65.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,text,"der region, or neurological diseases affecting shoulder motion, aside from SAIS.","[102.0, 109.0, 585.0, 159.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,2,paragraph_title,DIAGNOSIS OF SAIS,"[103.0, 183.0, 276.0, 205.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: DIAGNOSIS OF SAIS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +3,3,text,SAIS diagnosis is performed through the assessment of both clinical tests and MRI findings. The first step in patient evaluation involves complete medical assessments of the patient. To reduce interpr,"[102.0, 226.0, 588.0, 571.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,paragraph_title,MRI IMAGING AND ASSESSMENT,"[104.0, 593.0, 384.0, 616.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: MRI IMAGING AND ASSESSMENT""]",section_heading,0.6,body_zone,heading_like,none,True,True +3,5,text,"Prior to the study, two independent and blinded MSK radiologists reviewed the sagittal and coronal oblique T1- or T2/PD-weighted MRIs at parallel or 90° to the long-axis of the supraspinatus tendon fo","[101.0, 641.0, 588.0, 1373.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,STATISTICAL ANALYSIS,"[104.0, 1396.0, 304.0, 1420.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: STATISTICAL ANALYSIS""]",section_heading,0.6,body_zone,heading_like,none,True,True +3,7,text,"The Statistical Package for the Social Sciences (SPSS for Windows, version 23, IBM, Chicago IL, USA) was used to perform the statistical analysis. Frequency and percentages were calculated for categor","[101.0, 1441.0, 588.0, 1565.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"ables. A chi-squared test was used to observe the associa­ +tion. A P-value of <0.05 was considered statistically signifi­ +cant.","[601.0, 109.0, 1086.0, 182.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,ETHICAL CONSIDERATION,"[603.0, 206.0, 830.0, 229.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ETHICAL CONSIDERATION""]",section_heading,0.6,body_zone,heading_like,none,True,True +3,10,text,This study was approved by the Institutional Review Board of King Abdulaziz University with ethical approval Reference No. 350-20,"[601.0, 250.0, 1086.0, 325.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,RESULTS,"[603.0, 353.0, 695.0, 379.0]",section_heading,0.9,"[""explicit scholarly heading: RESULTS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,12,text,This study included 680 patients with suspected subacromial impingement syndrome (SAIS). Table 1 displays the demographic information of the study participants together with their MRI exam results (Ta,"[601.0, 406.0, 1088.0, 1265.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,text,Table 2 demonstrates the Type of acromion and AC degenerative changes with the presence of SAIS. Results show that Type II and Type III acromion shapes exist in 184 (46.8%) and 175 (44.5%) of patients,"[600.0, 1265.0, 1088.0, 1560.0]",table_caption,0.9,"[""table prefix matched: Table 2 demonstrates the Type of acromion and AC degenerativ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,14,footer,Orthopedic Reviews,"[534.0, 1621.0, 656.0, 1640.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,15,number,3,"[1069.0, 1618.0, 1085.0, 1642.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial...,"[249.0, 44.0, 938.0, 65.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,figure_title,Table 1. Patient demographics,"[104.0, 109.0, 376.0, 134.0]",table_caption,0.9,"[""table prefix matched: Table 1. 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VariablesSAIS suspected cases +n=680
Age
≤50327 (48.1%)
>50353 (51.9%)
Type I acromionType II acromionType III acromionType IV acromionMild AC degenerative changesModerate AC degenerative changes
VariablesSAIS
YesN(%)NoN(%)P-value
Gender
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MOJ. 2019;13(3):1-7. doi:10.5704/moj.1911.001,"[125.0, 212.0, 547.0, 304.0]",reference_item,0.85,"[""reference content label: 1. Dhillon KS. Subacromial Impingement Syndrome of the Shoul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,3,reference_content,"2. Utkan Karasu A, Kılıç A, Karaoğlan B. Efficacy of Transcutaneous Pulsed Radiofrequency Treatment in Subacromial Impingement Syndrome: A Randomized Controlled Study. J Clin Med. 2024;13(23):7462. do","[125.0, 332.0, 559.0, 445.0]",reference_item,0.85,"[""reference content label: 2. Utkan Karasu A, K\u0131l\u0131\u00e7 A, Karao\u011flan B. Efficacy of Transcu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,4,reference_content,"3. Park HJ, Lee SY, Choi YJ, et al. Association Between Subacromial Impingement and Acromiohumeral Distance on MRI. Iran J Radiol. 2018;15(2). doi:10.5812/iranjradiol.13811","[125.0, 475.0, 517.0, 567.0]",reference_item,0.85,"[""reference content label: 3. Park HJ, Lee SY, Choi YJ, et al. Association Between Suba""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,5,reference_content,"4. Azzoni R, Cabitza P, Parrini M. Sonographic evaluation of subacromial space. Ultrasonics. 2004;42(1-9):683-687. doi:10.1016/j.ultras.2003.11.015","[125.0, 595.0, 503.0, 687.0]",reference_item,0.85,"[""reference content label: 4. Azzoni R, Cabitza P, Parrini M. Sonographic evaluation of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,6,reference_content,"5. Colegate-Stone TJ, Tavakkolizadeh A, Sinha J. An analysis of acromioclavicular joint morphology as a factor for shoulder impingement syndrome. Shoulder Elbow. 2014;6(3):165-170. doi:10.1177/1758573","[126.0, 715.0, 557.0, 828.0]",reference_item,0.85,"[""reference content label: 5. Colegate-Stone TJ, Tavakkolizadeh A, Sinha J. An analysis""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,7,reference_content,"6. Horowitz EH, Aibinder WR. Shoulder Impingement Syndrome. PMR. 2023;34(2):311-334. doi:10.1016/j.pmr.2022.12.001","[125.0, 857.0, 560.0, 928.0]",reference_item,0.85,"[""reference content label: 6. Horowitz EH, Aibinder WR. Shoulder Impingement Syndrome. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,8,reference_content,7. Bağcı K. Scapula Morphometry and Types of Acromion. J Clin Pract Res. 2024;46(6):593-600. doi:10.14744/cpr.2024.98502,"[126.0, 954.0, 510.0, 1024.0]",reference_item,0.85,"[""reference content label: 7. Ba\u011fc\u0131 K. Scapula Morphometry and Types of Acromion. J Cli""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,9,reference_content,"8. Bigliani LU, Ticker JB, Flatow EL, et al. The Relationship of Acromial Architecture to Rotator Cuff Disease. Clin Sports Med. 1991;10(4):823-838. doi:10.1016/s0278-5919(20)30586-x","[125.0, 1052.0, 563.0, 1144.0]",reference_item,0.85,"[""reference content label: 8. Bigliani LU, Ticker JB, Flatow EL, et al. The Relationshi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,10,reference_content,"9. Tavakoli Darestani R, Afzal S, Baroutkoub M, et al. Evaluation of critical shoulder angle in patients with shoulder impingement syndrome and rotator cuff tear. Trauma Mon. 2023;28(6):957-964.","[125.0, 1172.0, 555.0, 1265.0]",reference_item,0.85,"[""reference content label: 9. Tavakoli Darestani R, Afzal S, Baroutkoub M, et al. Evalu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,11,reference_content,"10. Djade CD, Porgo TV, Zomahoun HT, et al. Incidence of shoulder pain in 40 years old and over and associated factors: A systematic review. Eur J Pain. 2020;24(1):39-50. doi:10.1002/ejp.1482","[126.0, 1293.0, 540.0, 1384.0]",reference_item,0.85,"[""reference content label: 10. Djade CD, Porgo TV, Zomahoun HT, et al. Incidence of sho""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,12,reference_content,"11. Garving C, Jakob S, Bauer I, et al. Impingement syndrome of the shoulder. Dtsch Arztebl Int. 2017;114(45):765. doi:10.3238/arztebl.2017.0765. PMID:29202926","[125.0, 1413.0, 539.0, 1503.0]",reference_item,0.85,"[""reference content label: 11. Garving C, Jakob S, Bauer I, et al. Impingement syndrome""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,13,reference_content,"12. Wang J, Ma JX, Zhu SW, et al. Does distal clavicle resection decrease pain or improve shoulder function in patients with acromioclavicular joint arthritis and rotator cuff tears? A meta-analysis. ","[625.0, 213.0, 1059.0, 348.0]",reference_item,0.85,"[""reference content label: 12. Wang J, Ma JX, Zhu SW, et al. Does distal clavicle resec""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,14,reference_content,"13. Rothenberg A, Gasbarro G, Chlebeck J, et al. The coracoacromial ligament: anatomy, function, and clinical significance. Orthop J Sports Med. 2017;5(4):2325967117703398. doi:10.1177/232596711770339","[625.0, 377.0, 1049.0, 491.0]",reference_item,0.85,"[""reference content label: 13. Rothenberg A, Gasbarro G, Chlebeck J, et al. The coracoa""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,15,reference_content,"14. Kubo H, Piela F, Patzer T, et al. Position of the acromioclavicular joint and relation to the critical shoulder angle in shoulders with rotator cuff tears. J Orthop. 2020;21:232-235. doi:10.1016/j","[625.0, 520.0, 1053.0, 633.0]",reference_item,0.85,"[""reference content label: 14. Kubo H, Piela F, Patzer T, et al. Position of the acromi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,16,reference_content,"15. Birtane M, Çalış M, Akgün K. The diagnostic value of magnetic resonance imaging in subacromial impingement syndrome. Yonsei Med J. +2001;42(4):418-424. doi:10.3349/ymj.2001.42.4.418","[626.0, 662.0, 1063.0, 754.0]",reference_item,0.85,"[""reference content label: 15. Birtane M, \u00c7al\u0131\u015f M, Akg\u00fcn K. The diagnostic value of mag""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,17,reference_content,"16. Hodgson RJ, O'Connor PJ, Grainger AJ. Tendon and ligament imaging. Br J Radiol. +2012;85(1016):1157-1172. doi:10.1259/bjr/34786470. +PMID:22553301","[626.0, 783.0, 1054.0, 873.0]",reference_item,0.85,"[""reference content label: 16. Hodgson RJ, O'Connor PJ, Grainger AJ. Tendon and ligamen""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,18,reference_content,"17. Seeger LL, Gold RH, Bassett LW, et al. Shoulder impingement syndrome: MR findings in 53 shoulders. AJR Am J Roentgenol. 1988;150(2):343-347. doi:10.2214/ajr.150.2.343","[625.0, 903.0, 1063.0, 994.0]",reference_item,0.85,"[""reference content label: 17. Seeger LL, Gold RH, Bassett LW, et al. Shoulder impingem""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,19,reference_content,"18. Guosheng Y, Chongxi R, Guoqing C, et al. The diagnostic value of a modified Neer test in identifying subacromial impingement syndrome. Eur J Orthop Surg Traumatol. 2017;27:1063-1067. doi:10.1007/s","[625.0, 1023.0, 1064.0, 1135.0]",reference_item,0.85,"[""reference content label: 18. Guosheng Y, Chongxi R, Guoqing C, et al. The diagnostic ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,20,reference_content,"19. TossY JD, Mead NC, Sigmond HM. Acromioclavicular Separations: Useful and Practical Classification for Treatment. Clin Orthop Relat Res. 1963;28:111-119. doi:10.1097/00003086-196300280-00012","[625.0, 1165.0, 1048.0, 1278.0]",reference_item,0.85,"[""reference content label: 19. TossY JD, Mead NC, Sigmond HM. Acromioclavicular Separat""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,21,reference_content,20. Morrison DS. The clinical significance of variations in acromial morphology. Presented at: ASES Open Meeting; 1987; San Francisco.,"[625.0, 1307.0, 1025.0, 1378.0]",reference_item,0.85,"[""reference content label: 20. Morrison DS. The clinical significance of variations in ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,22,reference_content,"21. Epstein RE, Schweitzer ME, Frieman BG, et al. Hooked acromion: prevalence on MR images of painful shoulders. Radiology. 1993;187(2):479-481. doi:10.1148/radiology.187.2.8475294","[625.0, 1406.0, 1037.0, 1497.0]",reference_item,0.85,"[""reference content label: 21. Epstein RE, Schweitzer ME, Frieman BG, et al. Hooked acr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,23,reference_content,"22. Chun JM, Yoo HW. Incidence of the acromial spur. J Shoulder Elbow Surg. 1994;3(Suppl):S20.","[624.0, 1525.0, 1061.0, 1572.0]",reference_item,0.85,"[""reference content label: 22. Chun JM, Yoo HW. Incidence of the acromial spur. 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The coracoac""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,2,reference_content,"24. Toivonen DA, Tuite MJ, Orwin JF. Acromial structure and tears of the rotator cuff. J Shoulder Elbow Surg. 1995;4(5):376-383. doi:10.1016/s10582746(95)80022-0","[126.0, 229.0, 522.0, 321.0]",reference_item,0.85,"[""reference content label: 24. Toivonen DA, Tuite MJ, Orwin JF. Acromial structure and ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,3,reference_content,"25. Shah NN, Bayliss NC, Malcolm A. Shape of the acromion: congenital or acquired—a macroscopic, radiographic, and microscopic study. J Shoulder Elbow Surg. 2001;10(4):30916. doi:10.1067/mse.2001.1146","[125.0, 348.0, 562.0, 462.0]",reference_item,0.85,"[""reference content label: 25. Shah NN, Bayliss NC, Malcolm A. Shape of the acromion: c""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,4,reference_content,"26. Kaur R, Dahuja A, Garg S, et al. Correlation of acromial morphology in association with rotator cuff tear: a retrospective study. Pol J Radiol. 2019;84:459-463. doi:10.5114/pjr.2019.90277. PMID:31","[126.0, 491.0, 559.0, 606.0]",reference_item,0.85,"[""reference content label: 26. Kaur R, Dahuja A, Garg S, et al. Correlation of acromial""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,5,reference_content,"27. Natsis K, Tsikaras P, Totlis T, et al. Correlation between the four types of acromion and the existence of enthesophytes. Clin Anat. 2007;20(3):267-272. doi:10.1002/ca.20320","[125.0, 634.0, 562.0, 726.0]",reference_item,0.85,"[""reference content label: 27. Natsis K, Tsikaras P, Totlis T, et al. Correlation betwe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,6,reference_content,"28. Hirano M, Ide J, Takagi K. Acromial shapes and extension of rotator cuff tears: magnetic resonance imaging evaluation. J Shoulder Elbow Surg. 2002;11(6):576-578. doi:10.1067/mse.2002.127097","[126.0, 754.0, 542.0, 846.0]",reference_item,0.85,"[""reference content label: 28. Hirano M, Ide J, Takagi K. Acromial shapes and extension""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,7,reference_content,29. Almekinder LC. Impingement syndrome. Clin Sports Med. 2001;20(3):491-504. doi:10.1016/S0278-5919(05)70265-9,"[626.0, 109.0, 1023.0, 178.0]",reference_item,0.85,"[""reference content label: 29. Almekinder LC. Impingement syndrome. Clin Sports Med. 20""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,8,reference_content,"30. Consigliere P, Haddo O, Levy O, et al. Subacromial impingement syndrome: management challenges. J Orthop Res. 2018;23:83-91. doi:10.2147/orr.s157864","[625.0, 206.0, 1063.0, 277.0]",reference_item,0.85,"[""reference content label: 30. Consigliere P, Haddo O, Levy O, et al. Subacromial impin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,9,reference_content,"31. Dalbøge A, Frost P, Andersen JH, et al. Exposure-response relationships between cumulative occupational shoulder exposures and different diagnoses related to surgery for subacromial impingement sy","[626.0, 303.0, 1063.0, 462.0]",reference_item,0.85,"[""reference content label: 31. Dalb\u00f8ge A, Frost P, Andersen JH, et al. Exposure-respons""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,10,reference_content,"32. Yao L, Lee HY, Gentili A, et al. Lateral down-sloping of the acromion: a useful MR sign? 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b/audit/4M64NZEC/audit_report.json new file mode 100644 index 00000000..26feee46 --- /dev/null +++ b/audit/4M64NZEC/audit_report.json @@ -0,0 +1,241 @@ +{ + "paper_key": "4M64NZEC", + "mode": "high-risk", + "status": "READY", + "focus": [], + "artifact_fingerprint": { + "result_json_hash": "sha256:6df677d3d48d267f7c686be26c302e32ddb64e2b54aca3455d12349bd48f99ac", + "meta_json_hash": "sha256:633164685fbdd115597c4807a7075f23313b0250587afd42d99e6f8e290e7254", + "blocks_raw_hash": "sha256:60f85b4968fbc7d4252623d47430578cc56b312f11d84ee9eb58b8465cca1bf2", + "structured_blocks_hash": "sha256:0ee85f47ea33c0547b847386e77024c096fab89f6e093ced474ac82aa408cff2", + "document_structure_hash": "sha256:29b45e499a8f3b8d9bcc415ed1f554de7e6f81f70aca364c873c1e8e89eb8d0a", + "figure_inventory_hash": "sha256:68aff30f19d06dbb172f10d9c4af5ab4f5186cf6e5e9a23e7d270535e2a3b774", + "table_inventory_hash": "sha256:c69f7deb4e15254009add91ed086220d03d9b4304d4c5ede183cd059adafa148", + "reader_figures_hash": "sha256:7f501387c80451ae2a2212fcabd746bef731cfe70c389e8bc40177108f58522b", + "resolved_metadata_hash": "sha256:ae280bc9d4e101c1aa4a93df3ea5b090709a93749417b97267c8a883f40baaec", + "fulltext_hash": "sha256:7c613e9b33a035af7e1d1997ec4e7599e21d172d0b43230ed4bc26a6fe22bd21", + "block_trace_hash": "sha256:051f99be773b8ec2402b4e87e29ccd491d2bd1553702e0b8a5e4964524f57a3e", + "annotated_pages": { + "page_001.png": "sha256:b3d782a7128aa0b3a4804d074aea59c20f43e3597cdbc6bc354843619a32c63f", + "page_002.png": "sha256:57972f405f699b7ae8bc2280880b347f3e6f60188eb882a62d792b53848139e7", + "page_003.png": "sha256:9492d67f3f283260600c44416d2ce9ee10de04f0627a2460459f8d20dfdb3377", + "page_004.png": "sha256:7a0f39feeb84f3ac44daad0d092251e93f47387b760db30fe663bf9cdb07f9fb", + "page_005.png": "sha256:681299f1565b7b7d50e8f8fb2e0b53c74dc490e64d3ef5b503c3ca9e4409aeb1" + } + }, + "artifact_freshness": { + "missing": [], + "mismatches": [ + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured", + "fulltext older than blocks_structured" + ], + "annotated_pages_rendered": [ + "page_001.png", + "page_002.png", + "page_003.png", + "page_004.png", + "page_005.png" + ] + }, + "reviewed_pages": [ + 1, + 2, + 3, + 4, + 5 + ], + "reviewed_blocks": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p2:5", + "p2:6", + "p2:7", + "p2:8", + "p2:9", + "p2:10", + "p2:11", + "p2:12", + "p2:13", + "p2:14", + "p2:15", + "p2:16", + "p2:17", + "p2:18", + "p2:19", + "p2:20", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:4", + "p3:5", + "p3:6", + "p3:7", + "p3:8", + "p3:9", + "p3:10", + "p3:11", + "p3:12", + "p3:13", + "p3:14", + "p3:15", + "p3:16", + "p3:17", + "p3:18", + "p3:19", + "p3:20", + "p3:21", + "p3:22", + "p3:23", + "p3:24", + "p3:25", + "p3:26", + "p3:27", + "p4:0", + "p4:1", + "p4:2", + "p4:3", + "p4:4", + "p4:5", + "p4:6", + "p4:7", + "p4:8", + "p4:9", + "p4:10", + "p4:11", + "p4:12", + "p4:13", + "p4:14", + "p4:15", + "p4:16", + "p5:0", + "p5:1", + "p5:2", + "p5:3", + "p5:4", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p5:11", + "p5:12", + "p5:13", + "p5:14", + "p5:15", + "p5:16", + "p5:17", + "p5:18", + "p5:19", + "p5:20", + "p5:21", + "p5:22", + "p5:23", + "p5:24", + "p5:25", + "p5:26", + "p5:27", + "p5:28", + "p5:29", + "p5:30", + "p5:31" + ], + "findings": [ + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_005.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:7", + "p1:8", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:17", + "p2:0", + "p2:1", + "p2:3", + "p2:6", + "p2:7", + "p2:9", + "p2:10", + "p2:11" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/4M64NZEC/audit_report.md b/audit/4M64NZEC/audit_report.md new file mode 100644 index 00000000..96d0108a --- /dev/null +++ b/audit/4M64NZEC/audit_report.md @@ -0,0 +1,19 @@ +# OCR Truth Audit Report - 4M64NZEC + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 3, 4, 5] +- Reviewed blocks: 118 + +## Findings + +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/4M64NZEC/audit_scope.json b/audit/4M64NZEC/audit_scope.json new file mode 100644 index 00000000..7f8a7853 --- /dev/null +++ b/audit/4M64NZEC/audit_scope.json @@ -0,0 +1,1232 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 3, + 4, + 5 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p2:3", + "p2:9", + "p2:10", + "p2:13", + "p3:4", + "p3:5", + "p3:6", + "p3:7", + "p3:8", + "p3:9", + "p3:10", + "p3:11", + "p3:12", + "p3:14", + "p3:16", + "p3:18", + "p3:19", + "p3:21", + "p3:22", + "p3:24", + "p3:26", + "p4:2", + "p4:4", + "p4:5", + "p4:7", + "p4:9", + "p4:10", + "p4:14", + "p5:5", + "p5:6", + "p5:7", + "p5:8", + "p5:9", + "p5:10", + "p5:11", + "p5:12", + "p5:13", + "p5:14", + "p5:15", + "p5:16", + "p5:17", + "p5:18", + "p5:19", + "p5:20", + "p5:21", + "p5:22", + "p5:23", + "p5:24", + "p5:25", + "p5:26", + "p5:27", + "p5:28", + "p5:29", + "p5:30" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + 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index 00000000..b83081bd --- /dev/null +++ b/audit/4M64NZEC/block_trace.csv @@ -0,0 +1,140 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,论 著,"[100.0, 87.0, 171.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header,影像研究与医学应用 2025年5月 第9卷第10期,"[366.0, 85.0, 837.0, 110.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,doc_title,MRI 检查在冻结肩诊断中的应用价值分析,"[244.0, 140.0, 977.0, 183.0]",paper_title,0.8,"[""page-1 zone title_zone: MRI \u68c0\u67e5\u5728\u51bb\u7ed3\u80a9\u8bca\u65ad\u4e2d\u7684\u5e94\u7528\u4ef7\u503c\u5206\u6790""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,乔祖康 $ ^{1} $,戴程炜 $ ^{2} $,徐海鹏 $ ^{1} $,熊俊龙 $ ^{1} $,赵沈阳 $ ^{1} $,常红生 $ ^{1} $(通信作者),"[283.0, 212.0, 932.0, 236.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,text,"(1 浙江中医药大学附属第一医院 < 浙江省中医院 > 医学影像科 浙江 杭州 310006) +(2 浙江中医药大学第三临床医学院 浙江 杭州 310053)","[228.0, 239.0, 996.0, 294.0]",unknown_structural,0.8,"[""page-1 zone title_zone: (1 \u6d59\u6c5f\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 < \u6d59\u6c5f\u7701\u4e2d\u533b\u9662 > \u533b\u5b66\u5f71\u50cf\u79d1 \u6d59\u6c5f \u676d\u5dde 310006)\n(2 \u6d59\u6c5f\u4e2d\u533b\u836f\u5927\u5b66\u7b2c\u4e09""]",paper_title,0.8,frontmatter_main_zone,support_like,none,False,True +1,5,abstract,【摘要】目的:探讨肩关节MRI在冻结肩(FS)的临床及影像诊断中的应用价值。方法:选取2022年8月—2023年8月浙江中医药大学附属第一医院收治的30例处于冻结期的FS患者作为观察组,并选取同期30名健康成人作为对照组。通过MRI测量两组的喙肱韧带(CHL)、腋囊(AR)和下盂肱韧带(IGHL)的厚度,并绘制受试者工作特征(ROC)曲线评估CHL、AR、IGHL厚度对FS的诊断价值,计算曲线下面,"[98.0, 347.0, 1126.0, 587.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,6,text,【关键词】冻结肩;磁共振成像;喙肱韧带;腋囊;下盂肱韧带;诊断价值,"[104.0, 595.0, 684.0, 620.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,7,text,【中图分类号】R445.2,"[105.0, 626.0, 295.0, 652.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True +1,8,text,【文献标识码】A,"[452.0, 626.0, 600.0, 652.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True +1,9,text,DOI:10.20267/j.issn.2096-3807.2025.10.002,"[768.0, 628.0, 1127.0, 651.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,False,False +1,10,doc_title,Analysis of the application value of MRI examination in the diagnosis of frozen shoulder,"[97.0, 708.0, 789.0, 733.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Analysis of the application value of MRI examination in the ""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,11,text,"QIAO Zukang $ ^{1} $, DAI Chengwei $ ^{2} $, XU Haipeng $ ^{1} $, XIONG Junlong $ ^{1} $, ZHAO Shenyang $ ^{1} $, CHANG Hongsheng $ ^{1} $ (Corresponding author)","[96.0, 738.0, 1127.0, 766.0]",frontmatter_support,0.78,"[""first-surviving-page support text: QIAO Zukang $ ^{1} $, DAI Chengwei $ ^{2} $, XU Haipeng $ ^{""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True +1,12,text," $ ^{1} $ veng $ ^{1} $, XIONG Junlong $ ^{1} $, ZHAO Shenyang $ ^{1} $, CHANG Hongsheng $ ^{1} $ (Corresponding author) + +1 Department of Medical Imaging, The First Affiliated Hospital of Zhejiang Uni","[97.0, 739.0, 1127.0, 825.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ veng $ ^{1} $, XIONG Junlong $ ^{1} $, ZHAO Shenyan""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,13,text,"2 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310035, China","[96.0, 833.0, 971.0, 858.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2 The Third Clinical Medical College, Zhejiang Chinese Medic""]",affiliation,0.8,frontmatter_main_zone,reference_like,reference_numeric_dot,True,True +1,14,abstract,【Abstract】Objective To explore the clinical and imaging diagnostic value of MRI shoulder joint in frozen shoulder (FS). Methods A total of 30 FS patients in the frozen stage admitted to the First Affi,"[94.0, 863.0, 1131.0, 1264.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,15,text,【Key words】Frozen shoulder; Magnetic resonance imaging; Coracohumeral ligament; Axillary recess; Inferior glenohumeral ligaments; Diagnostic value,"[96.0, 1270.0, 1126.0, 1326.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,16,text,冻结肩(frozen shoulder,FS)也称粘连性肩关节囊炎,是一种以肩关节囊进行性纤维化和韧带挛缩为特点的疾病,其典型特征包括关节囊和韧带的增厚以及肩关节腔体积的减小 $ ^{[1]} $。研究显示,FS的高发年龄段在50岁左右,总体发病率为2%~5%,女性发病率略高于男性,且以左肩更常见 $ ^{[2]} $。FS的诊断主要依据临床观察到的体征和症状,主要包括肩关节的广泛疼痛和运动功能受,"[98.0, 1389.0, 597.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,17,text,"病,其典型特征包括关节囊和韧带的增厚以及肩关节腔 +体积的减小 [1]。研究显示,FS 的高发年龄段在50 岁左 +右,总体发病率为2% ~5%,女性发病率略高于男性, +且以左肩更常见 [2]。FS 的诊断主要依据临床观察到的体 +征和症状,主要包括肩关节的广泛疼痛和运动功能受限","[622.0, 1388.0, 1128.0, 1541.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,empty,False,True +1,18,footnote,基金项目:浙江省医药卫生科技计划项目(2023KY855);浙江省中医药科技计划项目(2024ZL422)。,"[97.0, 1487.0, 597.0, 1539.0]",footnote,0.7,"[""footnote label: \u57fa\u91d1\u9879\u76ee\uff1a\u6d59\u6c5f\u7701\u533b\u836f\u536b\u751f\u79d1\u6280\u8ba1\u5212\u9879\u76ee\uff082023KY855\uff09\uff1b\u6d59\u6c5f\u7701\u4e2d\u533b\u836f\u79d1\u6280\u8ba1\u5212\u9879\u76ee\uff082024ZL422\uff09\u3002""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,19,number,4,"[100.0, 1568.0, 118.0, 1589.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +2,0,header,影像研究与医学应用 2025年5月 第9卷第10期,"[379.0, 85.0, 852.0, 110.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,1,header,论 著,"[1052.0, 87.0, 1122.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +2,2,text,"情况。根据2014年国际关节镜、膝关节外科和骨科运动医学学会(International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine, ISAKOS)上肢委员会制定的标准,肩部活动受限的具体指标包括前屈活动度不足100°、外旋小于10°及内旋未能达到L5水平 $ ^{[3]} $。尽管这些标准已在临床中得","[95.0, 139.0, 601.0, 819.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,3,paragraph_title,1 资料与方法 1.1 一般资料,"[98.0, 827.0, 267.0, 883.0]",non_body_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1 \u8d44\u6599\u4e0e\u65b9\u6cd5 1.1 \u4e00\u822c\u8d44\u6599""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,False,True +2,4,footer,,"[137.0, 860.0, 267.0, 883.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,empty,False,False +2,5,text,选取浙江中医药大学附属第一医院2022年8月—2023年8月收治的处于冻结期的30例FS患者作为观察组,另选取同期30名健康成人作为对照组(未报告任何肩部疼痛,且肩关节活动范围正常)。观察组男11例,女19例;年龄44~64岁,平均(53.97±5.19)岁;其中右肩患病者16例,左肩14例。对照组男11名,女19名;年龄40~66岁,平均(52.93±7.33)岁。两组的一般资料比较,差异无统计,"[95.0, 893.0, 599.0, 1211.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,6,text,纳入标准:(1)观察组患者符合 ISAKOS 对 FS 的诊断标准 $ ^{[3]} $;(2)年龄>18 岁;(3)观察组患者存在肩关节周围广泛性疼痛;(4)观察组患者病程超过 3 个月,处于冻结期;(5)接受肩部 MRI 检查。排除标准:(1)有肩部手术史;(2)有类风湿性关节炎病史;(3)存在全层肩袖撕裂;(4)在 6 周内接受过关节内类固醇注射;(5)合并严重基础性疾病,一般情况较差。,"[95.0, 1220.0, 599.0, 1441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,7,paragraph_title,1.2 方法,"[138.0, 1448.0, 228.0, 1472.0]",non_body_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2 \u65b9\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,False,True +2,8,text,MRI 检查:采用美国 GE 3.0T Discovery MR 750 扫描仪(GE Healthcare)。患者取仰卧中立位,上肢自然伸直并置于体侧,掌心朝向躯体,拇指朝上。扫描范围为肩锁关节水平至腋窝下缘。成像方位包括横断面、斜冠状面和斜矢状面 3 个方向的 FSE T₁WI 及 T₂WI 抑脂序列,扫描层厚设置为 4.0 mm,层间距为 4.5 mm。获取矢状位和冠状位 T₂ 加权图像,其,"[95.0, 1481.0, 600.0, 1539.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,9,text,"自然伸直并置于体侧,掌心朝向躯体,拇指朝上。扫 +描范围为肩锁关节水平至腋窝下缘。成像方位包括横 +断面、斜冠状面和斜矢状面3 个方向的FSE T1WI 及 +T2WI 抑脂序列,扫描层厚设置为4.0 mm,层间距为 +4.5 mm。获取矢状位和冠状位T2 加权图像,其中切片 +厚度<3 mm,交叉间隙为0.9 mm。扫描参数设置: +TR/TE=4 010 ms/76 ms,FOV 为150 mm×150 ","[622.0, 141.0, 1127.0, 394.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True +2,10,text,"将扫描获得的影像上传至影像存储和传输系统(Picture Archiving and Communication System, PACS)。为保证诊断的客观性和准确性,由2位未知诊断结果的放射科主治医师阅片,阅片者1具有5年放射诊断经验,阅片者2具有10年放射诊断经验。2位医师分别在斜矢状位 $ T_{2} $加权饱和脂肪图像上测量CHL最厚处,在斜冠状位 $ T_{2} $加权饱和脂肪图像上测","[623.0, 402.0, 1127.0, 656.0]",authors,0.8,"[""page-1 zone author_zone: \u5c06\u626b\u63cf\u83b7\u5f97\u7684\u5f71\u50cf\u4e0a\u4f20\u81f3\u5f71\u50cf\u5b58\u50a8\u548c\u4f20\u8f93\u7cfb\u7edf\uff08Picture Archiving and Communication Sys""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +2,11,paragraph_title,1.3 统计学方法,"[664.0, 663.0, 814.0, 687.0]",non_body_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.3 \u7edf\u8ba1\u5b66\u65b9\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,False,True +2,12,text,采用 SPSS 22.0 统计软件进行数据处理,符合正态分布的计量资料采用均数 ± 标准差 $ (\bar{x} \pm s) $ 表示,采用 t 检验;计数资料以频数(n)、百分率(%)表示,采用 $ x^{2} $ 检验。采用组内相关系数(intraclass correlation coefficient,ICC)评价观察者间信度,定量参数如下:ICC < 0.40 为较差;0.40 ≤,"[621.0, 696.0, 1129.0, 1081.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,13,paragraph_title,2 结果 2.1 两位阅片者测量 CHL、AR、IGHL 的一致性,"[624.0, 1089.0, 1099.0, 1146.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2 \u7ed3\u679c 2.1 \u4e24\u4f4d\u9605\u7247\u8005\u6d4b\u91cf CHL\u3001AR\u3001IGHL \u7684\u4e00\u81f4\u6027""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,False,True +2,14,footer,,"[663.0, 1121.0, 1099.0, 1146.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,empty,False,False +2,15,text,采用 Modle-“Two way Random” “Absolute Agreement” Single Measures 方法分析 ICC。ICC 值显示阅片者 1 与阅片者 2 对 CHL、AR、IGHL 的测量均为一致性优秀。见表 1。,"[622.0, 1155.0, 1127.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,16,paragraph_title,2.2 两组 CHL、AR、IGHL 厚度比较,"[664.0, 1252.0, 1000.0, 1276.0]",non_body_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.2 \u4e24\u7ec4 CHL\u3001AR\u3001IGHL \u539a\u5ea6\u6bd4\u8f83""]",subsection_heading,0.6,,heading_like,none,False,True +2,17,text,观察组的 CHL、AR、IGHL 厚度均大于对照组,差异有统计学意义(P < 0.05)。见表 2。,"[624.0, 1286.0, 1126.0, 1342.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,18,paragraph_title,2.3 CHL、AR、IGHL 厚度对 FS 的诊断效能,"[663.0, 1350.0, 1067.0, 1374.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3 CHL\u3001AR\u3001IGHL \u539a\u5ea6\u5bf9 FS \u7684\u8bca\u65ad\u6548\u80fd""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +2,19,text,CHL 增厚诊断 FS 的截断值为 5.995 mm,灵敏度为 1.000,特异度为 0.933;AR 增厚诊断 FS 的截断值为 6.7 mm,灵敏度为 0.800,特异度为 0.933;IGHL 增厚诊断 FS 的截断值为 3.5 mm,灵敏度为 0.700,特异度为 0.967。见表 3、图 1。,"[623.0, 1384.0, 1127.0, 1540.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,20,number,5,"[1107.0, 1567.0, 1124.0, 1589.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +3,0,header,论 著,"[100.0, 87.0, 172.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +3,1,header,影像研究与医学应用 2025年5月 第9卷第10期,"[365.0, 85.0, 838.0, 110.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +3,2,paragraph_title,2.4 FS 患者及健康者 CHL、AR、IGHL 影像特征及测量示意图,"[96.0, 140.0, 599.0, 195.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4 FS \u60a3\u8005\u53ca\u5065\u5eb7\u8005 CHL\u3001AR\u3001IGHL \u5f71\u50cf\u7279\u5f81\u53ca\u6d4b\u91cf\u793a\u610f\u56fe""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +3,3,text,病例 1:女,52 岁,临床诊断粘连性关节囊炎,斜矢状位 T₂WI FSE 脂肪抑制序列 MR 显示 CHL、AR、IGHL 均增厚(白色箭头,图 2a、3a、4a);病例 2,男,46 岁,健康人,斜矢状位 T₂WI FSE 脂肪抑制序列 MRI 显示 CHL、AR、IGHL 未见增厚(白色箭头,图 2b、3b、4b);图 2c、3c、4c 分别为 CHL、AR、IGHL 测量示意图。,"[95.0, 201.0, 602.0, 410.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +3,4,figure_title,表 1 2 位阅片者的 ICC 评估,"[242.0, 446.0, 454.0, 466.0]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 1 2 \u4f4d\u9605\u7247\u8005\u7684 ICC \u8bc4\u4f30""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +3,5,table,
指标ICC95%CI
CHL0.9890.977 ~ 0.994
AR0.9380.898 ~ 0.962
IGHL0.995
组别例数CHLARIGHL
观察组30$ 7.85 \pm 1.49 $$ 9.10 \pm 3.71 $$ 5.22 \pm 3.17 $
对照,"[99.0, 637.0, 595.0, 768.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +3,8,figure_title,表 3 CHL、AR、IGHL 增厚对 FS 的诊断效能,"[707.0, 142.0, 1044.0, 162.0]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 3 CHL\u3001AR\u3001IGHL \u589e\u539a\u5bf9 FS \u7684\u8bca\u65ad\u6548\u80fd""]",figure_caption,0.85,,legend_like,none,False,False +3,9,table,<,"[625.0, 166.0, 1124.0, 271.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +3,10,chart,,"[632.0, 322.0, 1024.0, 710.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +3,11,figure_title,图 1 CHL、AR、IGHL 增厚诊断 FS 的 ROC 曲线,"[693.0, 751.0, 1057.0, 773.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 1 CHL\u3001AR\u3001IGHL \u589e\u539a\u8bca\u65ad FS \u7684 ROC \u66f2\u7ebf""]",figure_caption,0.85,,legend_like,none,False,False +3,12,image,,"[238.0, 823.0, 482.0, 1068.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,13,figure_title,(a),"[344.0, 1085.0, 372.0, 1104.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,14,image,,"[490.0, 824.0, 738.0, 1068.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,15,figure_title,(b),"[606.0, 1085.0, 633.0, 1103.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,16,image,,"[765.0, 843.0, 969.0, 1051.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,17,figure_title,(c),"[852.0, 1085.0, 881.0, 1104.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,18,figure_title,"注:(a)CHL 增厚(箭头);(b)CHL 未见增厚(箭头);(c)CHL 测量示意(箭头)。 +图 2 FS 患者及健康人 CHL 影像特征及测量示意图","[129.0, 1112.0, 795.0, 1164.0]",figure_caption_candidate,0.85,"[""figure_title label: \u6ce8\uff1a\uff08a\uff09CHL \u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08b\uff09CHL \u672a\u89c1\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08c\uff09CHL \u6d4b\u91cf\u793a\u610f\uff08\u7bad\u5934\uff09\u3002\n\u56fe 2 FS \u60a3\u8005\u53ca\u5065""]",figure_caption,0.85,,legend_like,none,False,False +3,19,image,,"[238.0, 1198.0, 483.0, 1446.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,20,figure_title,(a),"[344.0, 1459.0, 372.0, 1475.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,21,image,,"[490.0, 1199.0, 739.0, 1446.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,22,figure_title,注:(a)AR 增厚(箭头);(b)AR 未见增厚(箭头);(c)AR 测量示意(箭头)。,"[129.0, 1487.0, 750.0, 1506.0]",figure_caption_candidate,0.85,"[""figure_title label: \u6ce8\uff1a\uff08a\uff09AR \u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08b\uff09AR \u672a\u89c1\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08c\uff09AR \u6d4b\u91cf\u793a\u610f\uff08\u7bad\u5934\uff09\u3002""]",figure_caption,0.85,,legend_like,none,False,False +3,23,figure_title,(b),"[599.0, 1457.0, 626.0, 1475.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,24,image,,"[772.0, 1235.0, 947.0, 1443.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,25,figure_title,(c),"[853.0, 1457.0, 881.0, 1476.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,26,figure_title,图 3 FS 患者及健康人 AR 影像特征及测量示意图,"[435.0, 1516.0, 789.0, 1538.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 3 FS \u60a3\u8005\u53ca\u5065\u5eb7\u4eba AR \u5f71\u50cf\u7279\u5f81\u53ca\u6d4b\u91cf\u793a\u610f\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +3,27,number,6,"[100.0, 1568.0, 117.0, 1589.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +4,0,header,影像研究与医学应用 2025年5月 第9卷第10期,"[379.0, 85.0, 852.0, 110.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +4,1,header,论 著,"[1052.0, 87.0, 1122.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +4,2,image,,"[227.0, 142.0, 477.0, 391.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +4,3,figure_title,(a),"[343.0, 403.0, 373.0, 422.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,4,image,,"[486.0, 142.0, 741.0, 391.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +4,5,image,,"[779.0, 179.0, 957.0, 391.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +4,6,figure_title,(b),"[605.0, 402.0, 633.0, 421.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,7,figure_title,注:(a)IGHL增厚(箭头);(b)IGHL未见增厚(箭头);(c)IGHL测量示意(箭头)。,"[129.0, 428.0, 795.0, 449.0]",figure_caption_candidate,0.85,"[""figure_title label: \u6ce8\uff1a\uff08a\uff09IGHL\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08b\uff09IGHL\u672a\u89c1\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08c\uff09IGHL\u6d4b\u91cf\u793a\u610f\uff08\u7bad\u5934\uff09\u3002""]",figure_caption,0.85,,legend_like,none,False,False +4,8,figure_title,(c),"[852.0, 403.0, 881.0, 422.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,9,figure_title,图 4 FS 患者及健康人 IGHL 影像特征及测量示意图,"[427.0, 456.0, 798.0, 477.0]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 4 FS \u60a3\u8005\u53ca\u5065\u5eb7\u4eba IGHL \u5f71\u50cf\u7279\u5f81\u53ca\u6d4b\u91cf\u793a\u610f\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +4,10,paragraph_title,3 讨论,"[96.0, 513.0, 177.0, 538.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3 \u8ba8\u8bba""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,False,True +4,11,text,FS 是一种常见的临床疾病,传统上被认为是一种自限性疾病,通常能够自行缓解。然而,近期的研究表明,41% 的 FS 患者在疾病发生 4 年后仍然遭受轻度至中度的症状困扰,其中 6% 的患者甚至出现严重的疼痛和功能丧失 $ ^{[11]} $。这一发现凸显了及时的临床诊断和治疗对于 FS 恢复的重要性。,"[95.0, 545.0, 599.0, 726.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,12,text,尽管目前对 FS 的具体病理机制尚不完全清楚 $ ^{[12]} $,且缺乏统一的客观诊断标准,FS 的诊断仍然主要依赖于临床检查。这种情况为实现 FS 的精准治疗带来了挑战。有研究开始利用 MRI 作为诊断 FS 的辅助手段 $ ^{[13]} $。根据关节镜和组织学观察,FS 的病理变化可分为 3 个阶段:Ⅰ期以炎症性滑膜反应为主,尚未形成粘连;Ⅱ期粘连开始形成,伴有血管性滑膜炎和 AR 折叠,"[95.0, 730.0, 598.0, 1102.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,13,text,本研究中,2名放射科医师独立测量所得的平均 ICC 分别为 0.989、0.938、0.995,表明测量结果具有极强的一致性和高度的可重复性。通过阅片者 2 的测量结果进一步证实了 FS 患者中 CHL、AR 和 IGHL 的厚度较正常人明显增厚,与相关研究结果相似 $ ^{[16-17]} $。近年来的 MRI 研究一致表明,肩关节囊及周围韧带的增厚,特别是 CHL、IGHL 和 AR,是诊断 ,"[95.0, 1107.0, 600.0, 1541.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,14,text,"囊及韧带增厚在FS 发病和诊断中的关键作用 [21]。其中 +是CHL 的增厚,被认为是FS 最典型的病理表现之一。 +CHL 起自喙突的外侧缘,延伸至肱骨大结节和小结节之 +间,并覆盖在冈上肌与肩胛下肌之间的肩袖间隙上 [22], +具有限制肱骨外旋的生理作用 [23]。CHL 厚度的准确测量 +依赖于其在MRI 图像上的显示率,而显示率又与肩袖间 +隙内脂肪的对比度密切相关。在本研究的60 例样本中, +C","[620.0, 511.0, 1127.0, 1259.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True +4,15,text,尽管 FS 患者在多个运动平面上的肩关节活动度均受到不同程度的影响,但主要以外旋、前屈和外展受限为主 $ ^{[5]} $。根据解剖学原理,CHL、AR 和 IGHL 是限制肩关节外展和外旋的关键结构。因此,CHL、AR 和 IGHL 的增厚可能是导致 FS 患者肩关节活动受限的主要原因,为临床诊断 FS 提供重要的参考依据。此外,Lin 等 $ ^{[25]} $的研究进一步证实减小 CHL 和,"[622.0, 1263.0, 1128.0, 1541.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,16,number,7,"[1107.0, 1567.0, 1125.0, 1589.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +5,0,header,论 著,"[100.0, 87.0, 171.0, 112.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +5,1,header,影像研究与医学应用 2025年5月 第9卷第10期,"[366.0, 85.0, 837.0, 110.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +5,2,text,可能有助于恢复 FS 患者的肩关节功能,提高患者的生活质量。,"[98.0, 139.0, 597.0, 198.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +5,3,text,综上所述,CHL、AR 和 IGHL 的增厚是 FS 的典型形态学特征。在斜矢状位上,CHL 的显示效果最佳,而在斜冠状位上则有利于展示 IGHL 和 AR 的解剖结构。特别是 CHL 的增厚,不仅具有高灵敏度和特异度,而且在 MRI 上易于识别,有望成为早期准确诊断、治疗 FS 的可靠依据。,"[96.0, 206.0, 599.0, 396.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +5,4,paragraph_title,【参考文献】,"[106.0, 435.0, 217.0, 459.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u3010\u53c2\u8003\u6587\u732e\u3011""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +5,5,reference_content,"[1] CHALLOUMAS D, BIDDLE M, MCLEAN M, et al. Comparison of treatments for frozen shoulder: a systematic review and meta-analysis [J]. JAMA Netw Open, 2020, 3(12): e2029581.","[103.0, 469.0, 598.0, 554.0]",reference_item,0.85,"[""reference content label: [1] CHALLOUMAS D, BIDDLE M, MCLEAN M, et al. Comparison of t""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,6,reference_content,"[2] TAMAI K, HAMADA J, NAGASE Y, et al. Frozen shoulder. An overview of pathology and biology with hopes to novel drug therapies [J]. Mod Rheumatol, 2024, 34(3): 439-443.","[103.0, 567.0, 598.0, 652.0]",reference_item,0.85,"[""reference content label: [2] TAMAI K, HAMADA J, NAGASE Y, et al. Frozen shoulder. An ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,7,reference_content,"[3] ITOI E, ARCE G, BAIN G I, et al. Shoulder stiffness: current concepts and concerns [J]. Arthroscopy, 2016, 32(7): 1402–1414.","[103.0, 665.0, 597.0, 719.0]",reference_item,0.85,"[""reference content label: [3] ITOI E, ARCE G, BAIN G I, et al. Shoulder stiffness: cur""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,8,reference_content,"[4] WISE S R, SEALES P, HOUSER A P, et al. Frozen shoulder: diagnosis and management [J]. Curr Sports Med Rep, 2023, 22 (9): 307–312.","[104.0, 731.0, 596.0, 784.0]",reference_item,0.85,"[""reference content label: [4] WISE S R, SEALES P, HOUSER A P, et al. Frozen shoulder: ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,9,reference_content,"[5] RAMIREZ J. Adhesive capsulitis: diagnosis and management [J]. Am Fam Physician, 2019, 99(5): 297–300.","[103.0, 797.0, 597.0, 849.0]",reference_item,0.85,"[""reference content label: [5] RAMIREZ J. Adhesive capsulitis: diagnosis and management""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,10,reference_content,"[6] PESSIS E, MIHOUBI F, FEYDY A, et al. Usefulness of intravenous contrast-enhanced MRI for diagnosis of adhesive capsulitis [J]. Eur Radiol, 2020, 30(11): 5981–5991.","[104.0, 863.0, 597.0, 947.0]",reference_item,0.85,"[""reference content label: [6] PESSIS E, MIHOUBI F, FEYDY A, et al. Usefulness of intra""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,11,reference_content,"[7] BANG Y S, PARK J, LEE S Y, et al. Value of anterior band of the inferior glenohumeral ligament area as a morphological parameter of adhesive capsulitis [J]. Pain Res Manag, 2019, 2019: 9301970.","[104.0, 961.0, 597.0, 1047.0]",reference_item,0.85,"[""reference content label: [7] BANG Y S, PARK J, LEE S Y, et al. 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Updated guid""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,14,reference_content,"[10] NAHM F S. Receiver operating characteristic curve: overview and practical use for clinicians [J]. Korean J Anesthesiol, 2022, 75(1): 25–36.","[103.0, 1322.0, 596.0, 1375.0]",reference_item,0.85,"[""reference content label: [10] NAHM F S. Receiver operating characteristic curve: over""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,15,reference_content,"[11] SUN G J, LI Q S, YIN Y, et al. Risk factors and predictive models for frozen shoulder [J]. Sci Rep, 2024, 14(1): 15261.","[103.0, 1387.0, 597.0, 1439.0]",reference_item,0.85,"[""reference content label: [11] SUN G J, LI Q S, YIN Y, et al. Risk factors and predict""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,16,reference_content,"[12] LEAFBLAD N, MIZELS J, TASHJIAN R, et al. Adhesive capsulitis [J]. Phys Med Rehabil Clin N Am, 2023, 34 (2): 453–468.","[104.0, 1452.0, 595.0, 1504.0]",reference_item,0.85,"[""reference content label: [12] LEAFBLAD N, MIZELS J, TASHJIAN R, et al. Adhesive capsu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,17,reference_content,"[13] PARK G Y, PARK J H, KWON D R, et al. Do the findings of magnetic","[103.0, 1518.0, 598.0, 1538.0]",reference_item,0.85,"[""reference content label: [13] PARK G Y, PARK J H, KWON D R, et al. Do the findings of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,18,reference_content,"resonance imaging, arthrography, and ultrasonography reflect clinical impairment in patients with idiopathic adhesive capsulitis of the shoulder? [J]. Arch Phys Med Rehabil, 2017, 98 (10): 1995–2001.","[664.0, 143.0, 1126.0, 226.0]",reference_item,0.85,"[""reference content label: resonance imaging, arthrography, and ultrasonography reflect""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +5,19,reference_content,"[14] MILLAR N L, MEAKINS A, STRUYF F, et al. Frozen shoulder [J]. Nat Rev Dis Primers, 2022, 8(1): 59.","[630.0, 238.0, 1125.0, 291.0]",reference_item,0.85,"[""reference content label: [14] MILLAR N L, MEAKINS A, STRUYF F, et al. Frozen shoulder""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,20,reference_content,"[15] ALAIA E F, SUBHAS N. Shoulder MR imaging and MR arthrography techniques: new advances [J]. Magn Reson Imaging Clin N Am, 2020, 28(2): 153–163.","[630.0, 304.0, 1123.0, 389.0]",reference_item,0.85,"[""reference content label: [15] ALAIA E F, SUBHAS N. 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"render_default": false, + "snippet": "论 著", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:2", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "情况。根据2014年国际关节镜、膝关节外科和骨科运动医学学会(International Society of Arthroscopy, Knee Surger", + "found_in_fulltext": true, + "fulltext_offset": 2901 + }, + { + "block_id": "p2:3", + "page": 2, + "role": "non_body_insert", + "zone": "reference_zone", + "render_default": false, + "snippet": "1 资料与方法 1.1 一般资料", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:5", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "选取浙江中医药大学附属第一医院2022年8月—2023年8月收治的处于冻结期的30例FS患者作为观察组,另选取同期30名健康成人作为对照组(未报告任何肩部疼痛,", + "found_in_fulltext": true, + "fulltext_offset": 3528 + }, + { + "block_id": "p2:6", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "纳入标准:(1)观察组患者符合 ISAKOS 对 FS 的诊断标准 $ ^{[3]} $;(2)年龄>18 岁;(3)观察组患者存在肩关节周围广泛性疼痛;(4)", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:7", + "page": 2, + "role": "non_body_insert", + "zone": "", + "render_default": false, + "snippet": "1.2 方法", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:8", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "MRI 检查:采用美国 GE 3.0T Discovery MR 750 扫描仪(GE Healthcare)。患者取仰卧中立位,上肢自然伸直并置于体侧,掌心朝", + "found_in_fulltext": true, + "fulltext_offset": 3991 + }, + { + "block_id": "p2:9", + "page": 2, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "自然伸直并置于体侧,掌心朝向躯体,拇指朝上。扫 描范围为肩锁关节水平至腋窝下缘。成像方位包括横 断面、斜冠状面和斜矢状面3 个方向的FSE T1WI 及 T2W", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:10", + "page": 2, + "role": "authors", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "将扫描获得的影像上传至影像存储和传输系统(Picture Archiving and Communication System, PACS)。为保证诊断的客观性", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:11", + "page": 2, + "role": "non_body_insert", + "zone": "", + "render_default": false, + "snippet": "1.3 统计学方法", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:12", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "采用 SPSS 22.0 统计软件进行数据处理,符合正态分布的计量资料采用均数 ± 标准差 $ (\\bar{x} \\pm s) $ 表示,采用 t 检验;计数资", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:13", + "page": 2, + "role": "unknown_structural", + "zone": "reference_zone", + "render_default": false, + "snippet": "2 结果 2.1 两位阅片者测量 CHL、AR、IGHL 的一致性", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:15", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "采用 Modle-“Two way Random” “Absolute Agreement” Single Measures 方法分析 ICC。ICC 值显示阅", + "found_in_fulltext": true, + "fulltext_offset": 4709 + }, + { + "block_id": "p2:16", + "page": 2, + "role": "non_body_insert", + "zone": "", + "render_default": false, + "snippet": "2.2 两组 CHL、AR、IGHL 厚度比较", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:17", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "观察组的 CHL、AR、IGHL 厚度均大于对照组,差异有统计学意义(P < 0.05)。见表 2。", + "found_in_fulltext": true, + "fulltext_offset": 4832 + }, + { + "block_id": "p2:18", + "page": 2, + "role": "subsection_heading", + "zone": "", + "render_default": true, + "snippet": "2.3 CHL、AR、IGHL 厚度对 FS 的诊断效能", + "found_in_fulltext": true, + "fulltext_offset": 4887 + }, + { + "block_id": "p2:19", + "page": 2, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "CHL 增厚诊断 FS 的截断值为 5.995 mm,灵敏度为 1.000,特异度为 0.933;AR 增厚诊断 FS 的截断值为 6.7 mm,灵敏度为 0.", + "found_in_fulltext": true, + "fulltext_offset": 4916 + }, + { + "block_id": "p2:20", + "page": 2, + "role": "noise", + "zone": "frontmatter_main_zone", + "render_default": false, + "snippet": "5", + "found_in_fulltext": true, + "fulltext_offset": 132 + }, + { + "block_id": "p3:0", + "page": 3, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "论 著", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:1", + "page": 3, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "影像研究与医学应用 2025年5月 第9卷第10期", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:2", + "page": 3, + "role": "subsection_heading", + "zone": "", + "render_default": true, + "snippet": "2.4 FS 患者及健康者 CHL、AR、IGHL 影像特征及测量示意图", + "found_in_fulltext": true, + "fulltext_offset": 5089 + }, + { + "block_id": "p3:3", + "page": 3, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "病例 1:女,52 岁,临床诊断粘连性关节囊炎,斜矢状位 T₂WI FSE 脂肪抑制序列 MR 显示 CHL、AR、IGHL 均增厚(白色箭头,图 2a、3a、", + "found_in_fulltext": true, + "fulltext_offset": 5126 + }, + { + "block_id": "p3:4", + "page": 3, + "role": "figure_caption_candidate", + "zone": "", + "render_default": false, + "snippet": "表 1 2 位阅片者的 ICC 评估", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:5", + "page": 3, + "role": "media_asset", + "zone": "", + "render_default": true, + "snippet": "
指标AUCP95%CI截断值灵敏度特异度
CHL0.990< 0.0010.973~1.0005.995 mm1.000
指标ICC95%CI
CHL0.989
组别例数CHLARIGHL
指标AUCP95%CI截断值灵敏度
Patients (n)Follow-up (years)StagingClinical scoreImaging and second lookKey features of the study
Park et al.
Piezoelectric biomaterials and their applications in cartilage regenulation.
TypesMaterialsMorphology DesignDimensionSyn","[69.0, 121.0, 1121.0, 1450.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,vision_footnote,(continued on next page),"[967.0, 1438.0, 1107.0, 1457.0]",footnote,0.7,"[""vision_footnote label: (continued on next page)""]",footnote,0.7,body_zone,body_like,none,True,True +6,5,number,6,"[589.0, 1515.0, 602.0, 1529.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Y. Wei et al.,"[71.0, 69.0, 146.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,1,header,Ultrasonics Sonochemistry 117 (2025) 107353,"[859.0, 69.0, 1120.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,figure_title,Table 1 (continued),"[71.0, 107.0, 204.0, 127.0]",table_caption,0.9,"[""table prefix matched: Table 1 (continued)""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +7,3,table,
TypesMaterialsMorphology DesignDimensionSynthesis RouteWorking ConditionPiezoelectric CoefficientRef.
PropertyBoneCartilage
Main cell populations responsive to PEMFOsteoblasts, MSCs, osteoclastsChondrocytes, chondroprogenitor cells, M","[97.0, 184.0, 1092.0, 464.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 4,4,text,"The dielectric and piezoelectric features of natural bone, responsible for the bioelectric signaling occurring within the tissue regulating its remodeling and homeostasis, have been previously demonst","[92.0, 517.0, 586.0, 995.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,5,text,"The primary origin of bone piezoelectricity arises from the noncentrosymmetric structure of COL1 fibers that, upon mechanical stimulation, slide over each other, creating a separation and polarization","[92.0, 996.0, 587.0, 1404.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -86,7 +86,7 @@ PUBLISHED 10 July 2025","[95.0, 639.0, 268.0, 696.0]",frontmatter_noise,0.8,"["" 5,12,footer,frontiersin.org,"[997.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,0,header,Masante et al.,"[96.0, 68.0, 191.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,1,header,10.3389/fbioe.2025.1557572,"[907.0, 67.0, 1094.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -6,2,figure_title,TABLE 2 Commercially available PEMF stimulators and operating parameters.,"[95.0, 160.0, 611.0, 180.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 2 Commercially available PEMF stimulators and operatin""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,2,figure_title,TABLE 2 Commercially available PEMF stimulators and operating parameters.,"[95.0, 160.0, 611.0, 180.0]",table_caption,0.9,"[""table prefix matched: TABLE 2 Commercially available PEMF stimulators and operatin""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 6,3,table,"
Device's nameCompany, countryWaveformMagnetic field intensity (B)Frequency (f)Pulse time (t)TunabilityReferences of s","[97.0, 181.0, 1093.0, 1094.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True 6,4,text,"waveform, and the exposure duration to the magnetic field. In detail, we calculated the PEMF dose (D), expressed in mT·h, as in Equation 1:","[94.0, 1124.0, 585.0, 1195.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,5,display_formula, $$ D=B_{r m s}\cdot t_{e x p} $$ ,"[282.0, 1213.0, 398.0, 1235.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True @@ -95,7 +95,7 @@ PUBLISHED 10 July 2025","[95.0, 639.0, 268.0, 696.0]",frontmatter_noise,0.8,"["" 6,8,text,The $ t_{exp} $ was calculated as in Equation 2:,"[121.0, 1473.0, 430.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,9,display_formula," $$ t_{\mathrm{e x p}}=E D_{d a y}\cdot E D_{w e e k}\cdot n_{w e e k}, $$ ","[228.0, 1512.0, 450.0, 1535.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True 6,10,formula_number,(2),"[559.0, 1511.0, 582.0, 1532.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True -6,11,figure_title,"TABLE 3 Formulas adopted for the calculation of $ B_{rms} $ depending on the waveform. $ B_{peak} $ is the peak intensity of the PEMF waveform, DC is the waveform duty cycle.","[604.0, 1125.0, 1089.0, 1173.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 3 Formulas adopted for the calculation of $ B_{rms} $""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,11,figure_title,"TABLE 3 Formulas adopted for the calculation of $ B_{rms} $ depending on the waveform. $ B_{peak} $ is the peak intensity of the PEMF waveform, DC is the waveform duty cycle.","[604.0, 1125.0, 1089.0, 1173.0]",table_caption,0.9,"[""table prefix matched: TABLE 3 Formulas adopted for the calculation of $ B_{rms} $""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 6,12,table,
PEMF waveform$ B_{rms} $
Square$ B_{rms} = B_{peak} \cdot \sqrt{DC} $
Triangular$ B_{rms} = \frac{B_{peak}}{\sqrt{3}} \cdot ,"[605.0, 1180.0, 1092.0, 1416.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 6,13,text,"where $ ED_{day} $ is the daily exposure duration to the PEMF stimulation (h/day), $ ED_{week} $ is the number of days of the week in which PEMF stimulation is applied (day/week), and $ n_{week} $ ","[603.0, 1441.0, 1096.0, 1537.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,14,footer,Frontiers in Bioengineering and Biotechnology,"[95.0, 1599.0, 403.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -117,7 +117,7 @@ PUBLISHED 10 July 2025","[95.0, 639.0, 268.0, 696.0]",frontmatter_noise,0.8,"["" 7,13,footer,frontiersin.org,"[997.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,0,header,Masante et al.,"[95.0, 68.0, 191.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,1,header,10.3389/fbioe.2025.1557572,"[907.0, 67.0, 1095.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -8,2,figure_title,TABLE 4 In vitro studies on the effects of PEMF stimulation on bone tissue.,"[95.0, 160.0, 600.0, 180.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 4 In vitro studies on the effects of PEMF stimulation ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +8,2,figure_title,TABLE 4 In vitro studies on the effects of PEMF stimulation on bone tissue.,"[95.0, 160.0, 600.0, 180.0]",table_caption,0.9,"[""table prefix matched: TABLE 4 In vitro studies on the effects of PEMF stimulation ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 8,3,table,
ReferenceCell origin and typePEMF stimulatorPEMF waveformPEMF parametersPEMF exposure durationMain biological outcomes/Signaling pa,"[96.0, 183.0, 1093.0, 1481.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True 8,4,vision_footnote,(Continued on following page),"[912.0, 1485.0, 1094.0, 1505.0]",footnote,0.7,"[""vision_footnote label: (Continued on following page)""]",footnote,0.7,body_zone,body_like,none,True,True 8,5,footer,Frontiers in Bioengineering and Biotechnology,"[95.0, 1598.0, 404.0, 1619.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -125,7 +125,7 @@ PUBLISHED 10 July 2025","[95.0, 639.0, 268.0, 696.0]",frontmatter_noise,0.8,"["" 8,7,footer,frontiersin.org,"[998.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 9,0,header,Masante et al.,"[96.0, 68.0, 191.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 9,1,header,10.3389/fbioe.2025.1557572,"[907.0, 68.0, 1095.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -9,2,figure_title,TABLE 4 (Continued) In vitro studies on the effects of PEMF stimulation on bone tissue.,"[94.0, 158.0, 681.0, 177.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 4 (Continued) In vitro studies on the effects of PEMF ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,2,figure_title,TABLE 4 (Continued) In vitro studies on the effects of PEMF stimulation on bone tissue.,"[94.0, 158.0, 681.0, 177.0]",table_caption,0.9,"[""table prefix matched: TABLE 4 (Continued) In vitro studies on the effects of PEMF ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 9,3,table,
ReferenceCell origin and typePEMF stimulatorPEMF waveformPEMF parametersPEMF exposure durationMain biological outcomes/Signaling pa,"[97.0, 175.0, 1093.0, 1169.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True 9,4,text,"involved in osteogenic differentiation, and increased microRNA and the vascular endothelial growth factor (VEGF) expression, which are both essential for promoting osteogenesis and angiogenesis (Baghe","[92.0, 1211.0, 587.0, 1546.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,5,text,,"[602.0, 1211.0, 1099.0, 1546.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True @@ -159,7 +159,7 @@ PUBLISHED 10 July 2025","[95.0, 639.0, 268.0, 696.0]",frontmatter_noise,0.8,"["" 11,11,footer,frontiersin.org,"[997.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 12,0,header,Masante et al.,"[95.0, 68.0, 192.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 12,1,header,10.3389/fbioe.2025.1557572,"[907.0, 67.0, 1095.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -12,2,figure_title,TABLE 5 In vitro studies on the effects of PEMF stimulation on cartilage tissue.,"[95.0, 160.0, 623.0, 180.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 5 In vitro studies on the effects of PEMF stimulation ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +12,2,figure_title,TABLE 5 In vitro studies on the effects of PEMF stimulation on cartilage tissue.,"[95.0, 160.0, 623.0, 180.0]",table_caption,0.9,"[""table prefix matched: TABLE 5 In vitro studies on the effects of PEMF stimulation ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 12,3,table,
ReferenceCell origin and typePEMF stimulatorPEMF waveformPEMF parametersPEMF exposure durationMain biological outcomes/ Signaling p,"[96.0, 182.0, 1092.0, 1317.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True 12,4,text,"(day) applied to human umbilical cord derived MSCs was observed to significantly enhance COL2 expression, with no differences between the devices utilized (Esposito et al., 2013). Differently, stimula","[92.0, 1355.0, 587.0, 1546.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,5,text,,"[602.0, 1356.0, 1098.0, 1546.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True @@ -197,7 +197,7 @@ Distribution of the root mean square value of the magnetic field intensity ( $ B 14,10,footer,frontiersin.org,"[997.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 15,0,header,Masante et al.,"[95.0, 68.0, 192.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 15,1,header,10.3389/fbioe.2025.1557572,"[907.0, 67.0, 1095.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -15,2,figure_title,TABLE 6 In vivo studies on the effects of PEMF stimulation on bone tissue.,"[95.0, 160.0, 597.0, 180.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 6 In vivo studies on the effects of PEMF stimulation o""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +15,2,figure_title,TABLE 6 In vivo studies on the effects of PEMF stimulation on bone tissue.,"[95.0, 160.0, 597.0, 180.0]",table_caption,0.9,"[""table prefix matched: TABLE 6 In vivo studies on the effects of PEMF stimulation o""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 15,3,table,
ReferenceSpeciesInvestigated conditionPEMF stimulatorPEMF waveformPEMF parametersPEMF exposureMain biological outcomes/ Si,"[96.0, 183.0, 1092.0, 1511.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True 15,4,vision_footnote,(Continued on following page),"[912.0, 1514.0, 1094.0, 1535.0]",footnote,0.7,"[""vision_footnote label: (Continued on following page)""]",footnote,0.7,body_zone,body_like,none,True,True 15,5,footer,Frontiers in Bioengineering and Biotechnology,"[94.0, 1598.0, 404.0, 1619.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -205,7 +205,7 @@ Distribution of the root mean square value of the magnetic field intensity ( $ B 15,7,footer,frontiersin.org,"[998.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 16,0,header,Masante et al.,"[95.0, 68.0, 191.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 16,1,header,10.3389/fbioe.2025.1557572,"[907.0, 68.0, 1095.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -16,2,figure_title,TABLE 6 (Continued) In vivo studies on the effects of PEMF stimulation on bone tissue.,"[94.0, 158.0, 678.0, 177.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 6 (Continued) In vivo studies on the effects of PEMF s""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +16,2,figure_title,TABLE 6 (Continued) In vivo studies on the effects of PEMF stimulation on bone tissue.,"[94.0, 158.0, 678.0, 177.0]",table_caption,0.9,"[""table prefix matched: TABLE 6 (Continued) In vivo studies on the effects of PEMF s""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 16,3,table,
ReferenceSpeciesInvestigated conditionPEMF stimulatorPEMF waveformPEMF parametersPEMF exposureMain biological outcomes/ Si,"[97.0, 181.0, 1093.0, 1160.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True 16,4,text,"female rats with osteopenia and subjected them to PEMF treatment (B = 0.5 mT, f = 15 Hz, triangular waveform, for 3 h/day over 6 weeks), observing increased elastic modulus of the hard callus across f","[93.0, 1211.0, 584.0, 1546.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 16,5,text,,"[602.0, 1211.0, 1099.0, 1545.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True @@ -238,7 +238,7 @@ Distribution of the root mean square value of the magnetic field intensity ( $ B 18,11,footer,frontiersin.org,"[997.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 19,0,header,Masante et al.,"[95.0, 68.0, 192.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 19,1,header,10.3389/fbioe.2025.1557572,"[907.0, 67.0, 1095.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -19,2,figure_title,TABLE 7 In vivo studies on the effects of PEMF stimulation on cartilage and osteochondral tissue.,"[95.0, 160.0, 748.0, 180.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 7 In vivo studies on the effects of PEMF stimulation o""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +19,2,figure_title,TABLE 7 In vivo studies on the effects of PEMF stimulation on cartilage and osteochondral tissue.,"[95.0, 160.0, 748.0, 180.0]",table_caption,0.9,"[""table prefix matched: TABLE 7 In vivo studies on the effects of PEMF stimulation o""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True 19,3,table,
ReferenceSpeciesInvestigated conditionPEMF stimulatorPEMF waveformPEMF parametersPEMF exposureMain biological outcomes/ Si,"[97.0, 182.0, 1093.0, 1193.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True 19,4,text,"OA. Both PEMF stimulation (B = 1.6 mT, f = 75 Hz, square waveform, for 1 h/day) and vibration treatment (frequency = 5 Hz, amplitude = 4 mm, gravitational acceleration = 0.3 g, for 20 min/day) were ap","[92.0, 1235.0, 586.0, 1547.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 19,5,text,,"[602.0, 1235.0, 1098.0, 1355.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True @@ -264,30 +264,30 @@ Distribution of the root mean square value of the magnetic field intensity ( $ B 21,2,text,evidence with greater translational relevance. These examples demonstrate that it is indeed feasible to design and implement protocols that maintain parameter fidelity throughout the translational pip,"[92.0, 160.0, 585.0, 279.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 21,3,text,"To facilitate the comparability of past and future research, here we proposed a quantitative approach based on the calculation of the PEMF dose—a comprehensive metric that integrates magnetic field in","[92.0, 280.0, 586.0, 902.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 21,4,text,"The method proposed for quantitative comparison is affected by some limitations. In the PEMF dose calculation, the frequency and pulse duration parameters are combined in the duty cycle and do not acc","[92.0, 902.0, 586.0, 1259.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -21,5,text,"For the future of PEMF research, it would be desirable to use, at least initially, the same parameters to ensure better comparability. Subsequently, it would make sense to systematically vary the vari","[92.0, 1262.0, 586.0, 1549.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True +21,5,text,"For the future of PEMF research, it would be desirable to use, at least initially, the same parameters to ensure better comparability. Subsequently, it would make sense to systematically vary the vari","[92.0, 1262.0, 586.0, 1549.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True 21,6,text,,"[603.0, 161.0, 1098.0, 565.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True 21,7,text,"In conclusion, this review provides a comprehensive overview of the current state of the art of in vitro and in vivo experiments investigating the biological effects of PEMF stimulation on bone and ca","[603.0, 567.0, 1098.0, 999.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -21,8,paragraph_title,Author contributions,"[604.0, 1039.0, 873.0, 1067.0]",backmatter_heading,0.8,"[""backmatter heading on page 21: Author contributions""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,support_like,none,True,True -21,9,text,"BM: Conceptualization, Investigation, Visualization, Writing – original draft. SG: Conceptualization, Formal Analysis, Investigation, Methodology, Writing – original draft. JS: Writing – original draf","[603.0, 1092.0, 1096.0, 1310.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -21,10,paragraph_title,Funding,"[606.0, 1350.0, 712.0, 1379.0]",backmatter_heading,0.8,"[""backmatter heading on page 21: Funding""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,heading_like,short_fragment,True,True -21,11,text,The author(s) declare that financial support was received for the research and/or publication of this article. This study was carried out within the scope of: 1) the BIGMECH project funded by European,"[602.0, 1404.0, 1097.0, 1548.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +21,8,paragraph_title,Author contributions,"[604.0, 1039.0, 873.0, 1067.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,True,True +21,9,text,"BM: Conceptualization, Investigation, Visualization, Writing – original draft. SG: Conceptualization, Formal Analysis, Investigation, Methodology, Writing – original draft. JS: Writing – original draf","[603.0, 1092.0, 1096.0, 1310.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +21,10,paragraph_title,Funding,"[606.0, 1350.0, 712.0, 1379.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Funding""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +21,11,text,The author(s) declare that financial support was received for the research and/or publication of this article. This study was carried out within the scope of: 1) the BIGMECH project funded by European,"[602.0, 1404.0, 1097.0, 1548.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 21,12,footer,Frontiers in Bioengineering and Biotechnology,"[95.0, 1598.0, 404.0, 1619.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 21,13,number,21,"[585.0, 1599.0, 605.0, 1616.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 21,14,footer,frontiersin.org,"[997.0, 1599.0, 1094.0, 1618.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 22,0,header,Masante et al.,"[95.0, 67.0, 191.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 22,1,header,10.3389/fbioe.2025.1557572,"[907.0, 67.0, 1095.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -22,2,text,"Marie Skłodowska-Curie Actions Individual Postdoctoral Fellowship 2023 (awarded to João C. Silva, HORIZON-MSCA-2023-PF-01, Project No. 101155027). This manuscript reflects only the authors' views and ","[92.0, 159.0, 586.0, 305.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -22,3,paragraph_title,Acknowledgments,"[94.0, 346.0, 332.0, 375.0]",backmatter_heading,0.8,"[""backmatter heading on page 22: Acknowledgments""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -22,4,text,The authors are grateful to Prof. Aldo Canova for technical explanations about PEMF generation and to Simona Salati from IGEA S.p.A. for the fruitful and valuable discussions on the perspectives of PE,"[92.0, 399.0, 585.0, 498.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -22,5,paragraph_title,Conflict of interest,"[94.0, 536.0, 338.0, 565.0]",backmatter_heading,0.8,"[""backmatter heading on page 22: Conflict of interest""]",backmatter_heading_candidate,0.8,frontmatter_side_zone,support_like,none,True,True -22,6,text,The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.,"[93.0, 590.0, 585.0, 662.0]",backmatter_body,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,True,True -22,7,paragraph_title,Generative AI statement,"[604.0, 154.0, 915.0, 183.0]",backmatter_heading,0.8,"[""backmatter heading on page 22: Generative AI statement""]",backmatter_heading_candidate,0.8,body_zone,heading_like,none,True,True +22,2,text,"Marie Skłodowska-Curie Actions Individual Postdoctoral Fellowship 2023 (awarded to João C. Silva, HORIZON-MSCA-2023-PF-01, Project No. 101155027). This manuscript reflects only the authors' views and ","[92.0, 159.0, 586.0, 305.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,3,paragraph_title,Acknowledgments,"[94.0, 346.0, 332.0, 375.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +22,4,text,The authors are grateful to Prof. Aldo Canova for technical explanations about PEMF generation and to Simona Salati from IGEA S.p.A. for the fruitful and valuable discussions on the perspectives of PE,"[92.0, 399.0, 585.0, 498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,5,paragraph_title,Conflict of interest,"[94.0, 536.0, 338.0, 565.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +22,6,text,The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.,"[93.0, 590.0, 585.0, 662.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +22,7,paragraph_title,Generative AI statement,"[604.0, 154.0, 915.0, 183.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Generative AI statement""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 22,8,paragraph_title,References,"[96.0, 705.0, 240.0, 732.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True 22,9,paragraph_title,Publisher's note,"[605.0, 297.0, 813.0, 326.0]",backmatter_heading,0.8,"[""backmatter heading on page 22: Publisher's note""]",backmatter_heading_candidate,0.8,body_zone,support_like,short_fragment,True,True -22,10,text,The author(s) declare that no Generative AI was used in the creation of this manuscript.,"[603.0, 207.0, 1095.0, 256.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -22,11,text,"All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.","[603.0, 351.0, 1097.0, 497.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -22,12,paragraph_title,Supplementary material,"[604.0, 536.0, 909.0, 567.0]",backmatter_heading,0.8,"[""backmatter heading on page 22: Supplementary material""]",backmatter_heading_candidate,0.8,body_zone,heading_like,none,True,True -22,13,text,The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbioe.2025.1557572/full#supplementary-material,"[604.0, 590.0, 1096.0, 662.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,10,text,The author(s) declare that no Generative AI was used in the creation of this manuscript.,"[603.0, 207.0, 1095.0, 256.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,11,text,"All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.","[603.0, 351.0, 1097.0, 497.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,12,paragraph_title,Supplementary material,"[604.0, 536.0, 909.0, 567.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supplementary material""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +22,13,text,The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbioe.2025.1557572/full#supplementary-material,"[604.0, 590.0, 1096.0, 662.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,14,reference_content,"Amin, B., Elahi, M. A., Shahzad, A., Porter, E., and O'Halloran, M. (2019). A review of the dielectric properties of the bone for low frequency medical technologies. Biomed. Phys. Eng. Express 5, 0220","[95.0, 753.0, 585.0, 804.0]",reference_item,0.85,"[""reference content label: Amin, B., Elahi, M. A., Shahzad, A., Porter, E., and O'Hallo""]",reference_item,0.85,reference_zone,unknown_like,none,True,True 22,15,reference_content,"Amini, A. R., Laurencin, C. T., and Nukavarapu, S. P. (2013). Bone tissue engineering: recent advances and challenges. 59.","[96.0, 810.0, 582.0, 844.0]",reference_item,0.85,"[""reference content label: Amini, A. R., Laurencin, C. T., and Nukavarapu, S. P. (2013)""]",reference_item,0.85,reference_zone,unknown_like,none,True,True 22,16,reference_content,"Ampatzis, C., Zervoudis, S., Iatrakis, G., and Mastorakos, G. (2022). Effect of oral contraceptives on bone mineral density. Acta Endocrinol. (Buchar) 18, 355–360. doi:10.4183/aeb.2022.355","[95.0, 849.0, 583.0, 899.0]",reference_item,0.85,"[""reference content label: Ampatzis, C., Zervoudis, S., Iatrakis, G., and Mastorakos, G""]",reference_item,0.85,reference_zone,unknown_like,none,True,True diff --git a/audit/7C8829BD/figure_table_ownership_summary.json b/audit/7C8829BD/figure_table_ownership_summary.json index 283c07d1..c4a79e13 100644 --- a/audit/7C8829BD/figure_table_ownership_summary.json +++ b/audit/7C8829BD/figure_table_ownership_summary.json @@ -1,7 +1,7 @@ { "figures": { "matched_count": 6, - "ambiguous_count": 1, + "ambiguous_count": 0, "unresolved_cluster_count": 0, "unmatched_asset_count": 1, "matched": [ @@ -60,15 +60,7 @@ "match_type": null } ], - "ambiguous": [ - { - "figure_number": 3, - "legend_block_id": 7, - "asset_block_ids": [], - "candidate_asset_ids": [], - "page": 10 - } - ], + "ambiguous": [], "unresolved": [] }, "tables": { diff --git a/audit/7C8829BD/fulltext_block_mapping_summary.json b/audit/7C8829BD/fulltext_block_mapping_summary.json index 2e9a108b..bf8d3a06 100644 --- a/audit/7C8829BD/fulltext_block_mapping_summary.json +++ b/audit/7C8829BD/fulltext_block_mapping_summary.json @@ -1,7 +1,7 @@ { - "mappable_block_count": 422, - "found_count": 380, - "missing_count": 42, + "mappable_block_count": 430, + "found_count": 346, + "missing_count": 84, "rows": [ { "block_id": "p1:0", @@ -26,9 +26,9 @@ { "block_id": "p1:7", "page": 1, - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", - "render_default": false, + "render_default": true, "snippet": "$ ^{†} $These authors have contributed equally to this work and share first auth", "found_in_fulltext": false, "fulltext_offset": -1 @@ -36,9 +36,9 @@ { "block_id": "p1:13", "page": 1, - "role": "unknown_structural", + "role": "paper_title", "zone": "frontmatter_main_zone", - "render_default": false, + "render_default": true, "snippet": "Insights into bone and cartilage responses to pulsed electromagnetic field stimu", "found_in_fulltext": true, "fulltext_offset": 2 @@ -81,7 +81,7 @@ "render_default": false, "snippet": "01", "found_in_fulltext": true, - "fulltext_offset": 2594 + "fulltext_offset": 2642 }, { "block_id": "p1:21", @@ -91,7 +91,7 @@ "render_default": false, "snippet": "frontiersin.org", "found_in_fulltext": true, - "fulltext_offset": 82538 + "fulltext_offset": 65714 }, { "block_id": "p2:0", @@ -130,8 +130,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Bone fragility fractures and osteoarthritis (OA) are two of the most prevalent d", - "found_in_fulltext": true, - "fulltext_offset": 2346 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p2:4", @@ -141,7 +141,7 @@ "render_default": true, "snippet": "Although bone has an intrinsic capacity for regeneration and functional recovery", "found_in_fulltext": true, - "fulltext_offset": 3724 + "fulltext_offset": 2327 }, { "block_id": "p2:5", @@ -151,7 +151,7 @@ "render_default": true, "snippet": "Beside conventional surgical procedures, bone and cartilage tissue engineering (", "found_in_fulltext": true, - "fulltext_offset": 5016 + "fulltext_offset": 3619 }, { "block_id": "p2:7", @@ -161,7 +161,7 @@ "render_default": true, "snippet": "Among the biophysical stimulations explored to promote bone and cartilage healin", "found_in_fulltext": true, - "fulltext_offset": 7395 + "fulltext_offset": 5998 }, { "block_id": "p2:8", @@ -191,7 +191,7 @@ "render_default": false, "snippet": "frontiersin.org", "found_in_fulltext": true, - "fulltext_offset": 82538 + "fulltext_offset": 65714 }, { "block_id": "p3:0", @@ -220,8 +220,8 @@ "zone": "body_zone", "render_default": true, "snippet": "tissue properties. 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"findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p12:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p13:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_013.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_012.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:3", + "p1:5", + "p1:6", + "p1:7", + "p1:12", + "p1:21", + "p1:22", + "p2:0", + "p2:1", + "p2:2", + "p2:6", + "p2:7", + "p2:9", + "p3:0", + "p3:1", + "p3:2", + "p3:5", + "p3:6", + "p3:7", + "p3:9" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/7S5ZEVSK/audit_report.md b/audit/7S5ZEVSK/audit_report.md new file mode 100644 index 00000000..ed1c991f --- /dev/null +++ b/audit/7S5ZEVSK/audit_report.md @@ -0,0 +1,39 @@ +# OCR Truth Audit Report - 7S5ZEVSK + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 4, 5, 6, 7, 8, 9, 10, 11, 12] +- Reviewed blocks: 99 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/7S5ZEVSK/audit_scope.json b/audit/7S5ZEVSK/audit_scope.json new file mode 100644 index 00000000..34b9a15c --- /dev/null +++ b/audit/7S5ZEVSK/audit_scope.json @@ -0,0 +1,909 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 4, + 5, + 6, + 7, + 8, + 9, + 10, + 11, + 12 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p1:21", + "p1:22", + "p4:2", + "p5:2", + "p5:4", + "p6:8", + "p6:10", + "p7:3", + "p7:6", + "p8:2", + "p9:2", + "p10:0", + "p10:2", + "p10:3", + "p10:4", + "p10:5", + "p11:0", + "p11:2", + "p11:3", + "p11:4", + "p11:5", + "p12:6", + "p12:9", + "p12:11", + "p12:12", + "p12:13", + "p12:14", + "p12:15", + "p12:16", + "p12:17", + "p12:18" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { 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'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header,"Journal of +Clinical Medicine","[146.0, 102.0, 339.0, 156.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,header_image,,"[1030.0, 103.0, 1120.0, 161.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,3,text,Article,"[67.0, 201.0, 131.0, 225.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,MR Imaging Biomarkers for Clinical Impairment and Disease Progression in Patients with Shoulder Adhesive Capsulitis: A Prospective Study,"[67.0, 226.0, 1088.0, 344.0]",paper_title,0.8,"[""page-1 zone title_zone: MR Imaging Biomarkers for Clinical Impairment and Disease Pr""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Romain Gillet $ ^{1,*} $, François Zhu $ ^{1} $, Pierre Padoin $ ^{1} $, Aymeric Rauch $ ^{1} $, Gabriela Hossu $ ^{2} $, Pedro Augusto Gondim Teixeira $ ^{1} $ and Alain Blum $ ^{1} $","[66.0, 373.0, 856.0, 426.0]",authors,0.8,"[""page-1 zone author_zone: Romain Gillet $ ^{1,*} $, Fran\u00e7ois Zhu $ ^{1} $, Pierre Pado""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text,"Guilloz Imaging Department, Central Hospital, University Hospital Center of Nancy, 54000 Nancy, France; f.zhu@chru-nancy.fr (F.Z.); pierre.padoin@gmail.com (P.P.); aym.rauch@gmail.com (A.R.); p.teixei","[327.0, 461.0, 1114.0, 529.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: Guilloz Imaging Department, Central Hospital, University Hos""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text," $ ^{2} $ CIC-II, CHKU Nancy, Université de Lorraine, 54000 Nancy, France; g.hossu@chru-nancy.fr","[329.0, 526.0, 1004.0, 549.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $ CIC-II, CHKU Nancy, Universit\u00e9 de Lorraine, 54000 N""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,8,image,,"[69.0, 729.0, 176.0, 766.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,9,text,* Correspondence: r.gillet@chru-nancy.fr; Tel.: +33-3-83-85-21-61; Fax: +33-3-83-85-97-25,"[327.0, 549.0, 975.0, 570.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: r.gillet@chru-nancy.fr; Tel.: +33-3-83-85-""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,10,text,"Citation: Gillet, R.; Zhu, F.; Padoin, P.; Rauch, A.; Hossu, G.; Teixeira, P.A.G.; Blum, A. MR Imaging Biomarkers for Clinical Impairment and Disease Progression in Patients with Shoulder Adhesive Cap","[66.0, 779.0, 309.0, 992.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Gillet, R.; Zhu, F.; Padoin, P.; Rauch, A.; Hossu,""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,text,"Received: 3 August 2021 +Accepted: 27 August 2021 +Published: 29 August 2021","[68.0, 1089.0, 238.0, 1159.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 3 August 2021 \nAccepted: 27 August 2021 \nPublish""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,12,text,Academic Editors: Mihra Taljanovic and Iwona Sudol-Szopińska,"[67.0, 1018.0, 297.0, 1063.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,13,text,Publisher's Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[67.0, 1188.0, 311.0, 1279.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=frontmatter_main_zone"", ""style_family=support_like""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False +1,14,image,,"[70.0, 1314.0, 187.0, 1358.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,15,text,"Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66.0, 1366.0, 311.0, 1553.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2021 by the authors. Licensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,16,abstract,"Abstract: Background: MRI diagnostic criteria of shoulder adhesive capsulitis (AC) are nowadays widely used, but there is little information available on the association between MRI findings and clini","[327.0, 598.0, 1124.0, 1115.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,17,text,Keywords: adhesive capsulitis; MRI; shoulder; constant-murley score; inferior gleno-humeral ligament,"[328.0, 1142.0, 1122.0, 1167.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: adhesive capsulitis; MRI; shoulder; constant-murle""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,18,paragraph_title,1. Introduction,"[331.0, 1241.0, 474.0, 1264.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,19,text,"Adhesive capsulitis (AC) of the shoulder is a common condition with an incidence in the general population varying considerably from 2 to 5.3% for primary and from 4.3 to 38% for secondary AC (e.g., A","[327.0, 1272.0, 1125.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,text,"AC is classically diagnosed based on clinical presentation, medical history, and physical examination. Diagnosing this condition, however, can be challenging as AC may occur","[328.0, 1498.0, 1126.0, 1549.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,21,footer,"J. Clin. Med. 2021, 10, 3882. https://doi.org/10.3390/jcm10173882","[67.0, 1624.0, 537.0, 1647.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,22,footer,https://www.mdpi.com/journal/jcm,"[842.0, 1625.0, 1118.0, 1648.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,number,2 of 14,"[1069.0, 103.0, 1121.0, 125.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,2,text,"in various clinical scenarios and has multiple potential differential diagnoses (e.g., rotator cuff tears, calcifying tendonitis, osteoarthritis, inflammatory tumors …) [2]. Imaging plays an ever-grow","[328.0, 189.0, 1123.0, 365.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Patients with AC typically complain of a gradual and progressive onset of pain, sleep-disturbing night pain, and active and passive limitation at various degrees of ranges of motion (ROM), both in ele","[327.0, 365.0, 1126.0, 669.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,paragraph_title,2. Material and Methods 2.1. Study Group,"[330.0, 686.0, 562.0, 738.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Material and Methods 2.1. Study Group""]",section_heading,0.85,frontmatter_side_zone,heading_like,heading_numbered,True,True +2,5,footer,,"[330.0, 713.0, 481.0, 738.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,6,text,"Our institutional review board approved this study, and all patients gave written informed consent. From 10 October 2013 to 16 October 2017, 170 patients over 18 years of age were enrolled prospective","[327.0, 745.0, 1123.0, 869.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"Patients with MRI contraindications, prior shoulder surgery, severe rotator cuff damage with at least a full-thickness tear of one tendon, shoulder osteoarthritis (osteophytes on radiographs), calcifi","[327.0, 871.0, 1124.0, 1098.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,2.2. Shoulder Function Assessment,"[330.0, 1115.0, 625.0, 1138.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Shoulder Function Assessment""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,text,A modified CMS was applied to all patients by a senior radiologist just prior to the MRI examination [19]. Two subjective variables for a maximum score of 35 were evaluated: daily living pain (varying,"[328.0, 1148.0, 1124.0, 1549.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 103.0, 258.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,3 of 14,"[1069.0, 103.0, 1120.0, 125.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,2,text,"In addition to the modified CMS score, the pain duration was graded as follows:","[371.0, 192.0, 1087.0, 218.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,1 = less than 6 weeks,"[330.0, 224.0, 524.0, 247.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,4,text,2 = between 6 weeks and 3 months,"[330.0, 249.0, 647.0, 273.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,5,text,3 = between 3 and 6 months,"[330.0, 274.0, 586.0, 298.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,6,text,4 = between 6 months and 1 year,"[330.0, 300.0, 629.0, 323.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,7,text,5 = over 1 year,"[330.0, 325.0, 470.0, 349.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,reference_like,reference_numeric_dot,False,True +3,8,text,"The presence of diurnal pain, nocturnal pain, and nocturnal pain predominance were also evaluated.","[328.0, 356.0, 1121.0, 406.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,2.3. Clinical Follow-Up,"[330.0, 425.0, 529.0, 450.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Clinical Follow-Up""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,10,text,A clinical follow-up was available in a sub-group of 49 patients with a mean age of $ 54 \pm 8.8 $ (37–74) years treated by physical therapy. Other patients were lost to follow-up or were treated in ,"[328.0, 456.0, 1123.0, 634.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,2.4. Mri Examination,"[330.0, 652.0, 516.0, 675.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Mri Examination""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,12,text,"MRI examinations were performed with either a 1.5 T (105 patients) or a 3.0 T (27 patients) scanner (Signa HDxt, GE Healthcare, Milwaukee, WI, USA) using a dedicated eight-channel shoulder coil and si","[327.0, 682.0, 1125.0, 758.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,text,"All MRI examinations consisted of an axial and oblique sagittal fast spin-echo (FSE) T1-weighted acquisitions (at 1.5 T: TR/TE, 500/10; echo-train length (ETL), 2; matrix, 352 × 320; NEX, 0.5; FOV, 16","[327.0, 758.0, 1125.0, 961.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,paragraph_title,2.5. Image Analysis,"[330.0, 979.0, 500.0, 1004.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Image Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,15,text,"The images were retrospectively reviewed by two musculoskeletal radiologists with three (FZ) and seven years (PP) of clinical experience with MRI using a PACS station (Synapse $ ^{\circledR} $, v4.1.6","[327.0, 1010.0, 1123.0, 1160.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,16,text,The signal intensity of the IGHL on oblique coronal T2-weighted fat-saturated images was graded as follows (Figure 1):,"[329.0, 1161.0, 1122.0, 1212.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,17,text,1: normal homogenous low signal intensity,"[330.0, 1217.0, 722.0, 1243.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,18,text,2: partial or foci of signal hyperintensity,"[330.0, 1243.0, 694.0, 1267.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,19,text,3: global signal hyperintensity,"[330.0, 1268.0, 607.0, 1291.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,20,text,4: linear hyperintensity of the peri-articular soft tissues,"[330.0, 1292.0, 823.0, 1317.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,4 of 14,"[1069.0, 103.0, 1121.0, 125.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,2,image,,"[193.0, 196.0, 997.0, 883.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,3,figure_title,Figure 1. (a–d) Frontal oblique non-contrast fat-suppressed T2-weighted fast spin-echo MRI shows method used to grade glenohumeral inferior ligament signal on its glenoidal (white arrow) and humeral (,"[108.0, 905.0, 1083.0, 1085.0]",figure_caption,0.92,"[""figure_title label: Figure 1. (a\u2013d) Frontal oblique non-contrast fat-suppressed ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,4,text,"The whole ligamentous complex was considered in the analysis: the anterior band, posterior band, and hammock portion. The patients with IGHL scores of 1 and 2 were considered to have a low IGHL signal","[326.0, 1103.0, 1125.0, 1356.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 126.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,5 of 14,"[1069.0, 102.0, 1121.0, 125.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,2,image,,"[342.0, 198.0, 818.0, 777.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,Figure 2. Coronal oblique non-contrast fat-suppressed T2-weighted fast spin-echo MRI of the right shoulder in a 44-year-old woman with adhesive capsulitis shows method used to measure inferior glenohu,"[327.0, 799.0, 1125.0, 903.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Coronal oblique non-contrast fat-suppressed T2-wei""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,image,,"[341.0, 934.0, 842.0, 1449.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,figure_title,Figure 3. Sagittal oblique non-contrast fat-suppressed T2-weighted fast spin-echo MRI of the left shoulder in a 55-year-old man with adhesive capsulitis shows method used to measure coracohumeral liga,"[328.0, 1472.0, 1124.0, 1551.0]",figure_caption,0.92,"[""figure_title label: Figure 3. Sagittal oblique non-contrast fat-suppressed T2-we""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,6 of 14,"[1069.0, 103.0, 1121.0, 125.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,2,paragraph_title,2.6. Statistical Analysis,"[330.0, 192.0, 533.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,3,text,"The R Development Core Team software (version 3.0.12013, R Foundation for Statistical Computing, Vienna, Austria) was used to perform statistical analysis. Statistical significance for all tests was d","[327.0, 224.0, 1123.0, 323.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,citation_line,True,True +6,4,text,"Linear regression analysis with the Pearson test was used to evaluate the correlation between the signs of AC studied on MRI and pain, mobility, activity scores, and pain duration. The association bet","[326.0, 325.0, 1125.0, 526.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,paragraph_title,3. Results,"[329.0, 545.0, 428.0, 569.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,6,text,"Table 1 shows demographic characteristics and modified CMS in the study population. The mean global modified CMS was $ 31.3 \pm 14.2 $ (2–69) points, and the mean pain duration grade was $ 3.5 \pm 1","[326.0, 576.0, 1125.0, 778.0]",table_caption,0.9,"[""table prefix matched: Table 1 shows demographic characteristics and modified CMS i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,7,figure_title,Table 1. Summary of patients' ages and clinical impairment items.,"[326.0, 796.0, 861.0, 819.0]",table_caption,0.9,"[""table prefix matched: Table 1. Summary of patients' ages and clinical impairment i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,8,table,
ParameterMinimumMaximumMeanStandard Deviation
Patient Age
All patients ( $ n = ,"[70.0, 828.0, 1118.0, 1074.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,9,figure_title,Table 2. Summary of patients' pain characteristics.,"[329.0, 1112.0, 738.0, 1136.0]",table_caption,0.9,"[""table prefix matched: Table 2. Summary of patients' pain characteristics.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,10,table,","[70.0, 490.0, 1119.0, 629.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +7,7,vision_footnote,"Values are given in millimeters. IGHL: inferior glenohumeral ligament, CHL: coracohumeral ligament. R1: Reader 1, R2: Reader 2.","[130.0, 634.0, 1058.0, 656.0]",footnote,0.7,"[""vision_footnote label: Values are given in millimeters. IGHL: inferior glenohumeral""]",footnote,0.7,body_zone,body_like,none,True,True +7,8,text,"ICC was excellent in grading IGHL signal as low or high (0.96), and moderate when taking in account all the four grades (0.67). ICC values were moderate for IGHL thickness (glenoidal insertion: 0.72, ","[326.0, 679.0, 1122.0, 756.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,Mobility scores were significantly different in patients with high IGHL signal intensity compared to those with low intensity for both readers (p = 0.04 and 0.02 for readers 1 and 2). The mean mobilit,"[327.0, 755.0, 1124.0, 905.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,"For both readers, pain duration was significantly shorter in patients with high IGHL signal intensity compared to those with a low signal IGHL (p = 0.03 and 0.04 for readers 1 and 2). The pain duratio","[327.0, 906.0, 1124.0, 1105.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,text,"The glenoidal IGHL thickness was significantly correlated with activity limitation scores for reader 1 (p = 0.005). Patients with IGHL measuring < 4 mm, between 4 and <6 mm, and ≥6 mm presented a prog","[327.0, 1106.0, 1125.0, 1458.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,12,text,CHL measurements are shown in Table 4. This ligament could not be measured confidently in five patients for reader 1 and 20 patients for reader 2. There was no association between CHL thickness and cl,"[327.0, 1458.0, 1125.0, 1533.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 126.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 14,"[1068.0, 103.0, 1121.0, 125.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,chart,,"[125.0, 202.0, 1064.0, 1135.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,3,figure_title,Figure 4. Box-plot showing mean mobility score (y-axis) according to inferior glenohumeral ligament intensity grade (x-axis) for reader 1 and reader 2.,"[108.0, 1158.0, 1083.0, 1209.0]",figure_caption,0.92,"[""figure_title label: Figure 4. Box-plot showing mean mobility score (y-axis) acco""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 103.0, 259.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,number,9 of 14,"[1069.0, 103.0, 1121.0, 124.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,chart,,"[85.0, 204.0, 1112.0, 1143.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,3,figure_title,"Figure 5. Bar plot representing pain score duration (PDS) (number of patients on y-axis) according to inferior glenohumeral ligament signal intensity (IGHL SI) (x-axis), shown for reader 1 for grade 1","[108.0, 1176.0, 1084.0, 1254.0]",figure_caption,0.92,"[""figure_title label: Figure 5. Bar plot representing pain score duration (PDS) (n""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,4,text,"Concerning disease progression, 31 patients (13 men, 18 women, mean age $ 55 \pm 9.1 $ (38–74) years) showed improvement, 11 patients (2 men, 9 women, mean age $ 55 \pm 10.1 $ (37–67) years) stabili","[327.0, 1270.0, 1125.0, 1550.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 126.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +10,1,number,10 of 14,"[1062.0, 102.0, 1121.0, 126.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,text," $ (p = 0.2) $. For both readers, the presence of high IGHL signal intensity was not significantly correlated with disease progression $ (p > 0.05) $. In patients with worsening, IGHL was found to be","[328.0, 191.0, 1123.0, 296.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +10,3,image,,"[82.0, 345.0, 1108.0, 1385.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +10,4,figure_title,"Figure 6. Box plot representing inferior glenohumeral ligament thickness (y-axis) according to clinical outcomes for reader 1 on the glenoidal (a) and humeral side (b), and for reader 2 on the glenoid","[108.0, 1406.0, 1082.0, 1458.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 6. Box plot representing inferior glenohumeral ligame""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +10,5,text,"For both readers, there was no association between CMS modified global score, pain intensity grade, diurnal pain, and MRI findings.","[327.0, 1475.0, 1125.0, 1529.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,1,header,11 of 14,"[1062.0, 103.0, 1121.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,paragraph_title,4. Discussion,"[329.0, 193.0, 460.0, 216.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True +11,3,text,"Our study showed a significant correlation between high IGHL signal intensity and the pain duration in patients with AC, with a clear high signal predominance in the patients presenting with pain from","[326.0, 222.0, 1124.0, 953.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,4,text,"Unlike Anh et al. [26], we did not find any correlation between MRI findings and the degree of pain, but we did not rate IGHL enhancement, as its signal on T2-weighted fat-saturated FSE images has bee","[327.0, 952.0, 1126.0, 1304.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,5,text,"This study has limitations. Most importantly, AC diagnosis was confirmed neither by arthroscopy nor histologically. However, clinical findings remain the basis for the diagnosis of AC, and the diagnos","[326.0, 1304.0, 1125.0, 1557.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +12,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 102.0, 259.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,12 of 14,"[1062.0, 103.0, 1121.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,text,"heterogeneous with various disease stages and clinical impairment levels; however, the study population is one of the largest reported so far and is representative of routine clinical practice. Finall","[327.0, 193.0, 1123.0, 292.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,text,"In conclusion, two potentially useful MR biomarkers in patients with AC could be identified. First, the increased T2 signal intensity at the IGHL, which is an indicator of an early inflammatory phase ","[327.0, 294.0, 1124.0, 470.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,"Supplementary Materials: The following are available online at https://www.mdpi.com/article/10.3390/jcm10173882/s1, Table S1: Modified Constant-Murley Score.","[328.0, 493.0, 1123.0, 541.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"Author Contributions: Conceptualization, R.G. and P.A.G.T.; methodology, P.A.G.T.; software, G.H.; validation, R.G., A.B. and P.A.G.T. formal analysis, A.B.; investigation, A.R.; resources, F.Z. and P","[328.0, 552.0, 1126.0, 670.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,support_like,none,True,True +12,6,text,Funding: This research received no external funding.,"[330.0, 682.0, 759.0, 706.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,text,Institutional Review Board Statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of the University Hospital of Na,"[328.0, 717.0, 1123.0, 788.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,8,text,Informed Consent Statement: Written informed consent was obtained from all subjects involved in the study.,"[328.0, 799.0, 1123.0, 846.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,Conflicts of Interest: The authors declare no conflict of interest.,"[329.0, 858.0, 842.0, 882.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +12,10,paragraph_title,Abbreviations,"[330.0, 906.0, 468.0, 930.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Abbreviations""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +12,11,table,
ParameterEffective
Pain Duration Graden = 112 $ * $
14.5% (n = 5)
213.4% (n = 15)
IGHL Signal IntensityPain Duration Grade
Reader 1Reader 2Reader 1Reader 2
ParameterMinimumMaximumMeanStandard Deviation
R1R2R1
,"[325.0, 955.0, 773.0, 1142.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +12,12,paragraph_title,References,"[68.0, 1166.0, 176.0, 1189.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +12,13,reference_content,"1. Kelley, M.J.; Shaffer, M.A.; Kuhn, J.E.; Michener, L.A.; Seitz, A.L.; Uhl, T.L.; Godges, J.J.; McClure, P. Shoulder Pain and Mobility Deficits: Adhesive Capsulitis: Clinical Practice Guidelines Lin","[67.0, 1197.0, 1123.0, 1286.0]",reference_item,0.85,"[""reference content label: 1. Kelley, M.J.; Shaffer, M.A.; Kuhn, J.E.; Michener, L.A.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,14,reference_content,"2. Brue, S.; Valentin, A.; Forssblad, M.; Werner, S.; Mikkelsen, C.; Cerulli, G. Idiopathic adhesive capsulitis of the shoulder: A review. Knee Surg. Sports Traumatol. Arthrosc. 2007, 15, 1048–1054. [","[67.0, 1289.0, 1123.0, 1333.0]",reference_item,0.85,"[""reference content label: 2. Brue, S.; Valentin, A.; Forssblad, M.; Werner, S.; Mikkel""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,15,reference_content,"3. D'Orsi, G.M.; Via, A.G.; Frizziero, A.; Oliva, F. Treatment of adhesive capsulitis: A review. Muscles Ligaments Tendons J. 2012, 2, 70–78.","[67.0, 1335.0, 1123.0, 1377.0]",reference_item,0.85,"[""reference content label: 3. D'Orsi, G.M.; Via, A.G.; Frizziero, A.; Oliva, F. Treatme""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,16,reference_content,"4. Sano, H.; Hatori, M.; Mineta, M.; Hosaka, M.; Itoi, E. Tumors masked as frozen shoulders: A retrospective analysis. J. Shoulder Elbow Surg. 2010, 19, 262–266. [CrossRef]","[68.0, 1381.0, 1122.0, 1424.0]",reference_item,0.85,"[""reference content label: 4. Sano, H.; Hatori, M.; Mineta, M.; Hosaka, M.; Itoi, E. Tu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,17,reference_content,"5. Zappia, M.; Di Pietto, F.; Aliprandi, A.; Pozza, S.; De Petro, P.; Muda, A.; Sconfienza, L.M. Multi-modal imaging of adhesive capsulitis of the shoulder. Insights Imaging 2016, 7, 365–371. [CrossRe","[67.0, 1427.0, 1122.0, 1471.0]",reference_item,0.85,"[""reference content label: 5. Zappia, M.; Di Pietto, F.; Aliprandi, A.; Pozza, S.; De P""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,18,reference_content,"6. Teixeira, P.A.G.; Balaj, C.; Chanson, A.; Lecocq, S.; Louis, M.; Blum, A. Adhesive Capsulitis of the Shoulder: Value of Inferior Glenohumeral Ligament Signal Changes on T2-Weighted Fat-Saturated Im","[67.0, 1473.0, 1123.0, 1540.0]",reference_item,0.85,"[""reference content label: 6. Teixeira, P.A.G.; Balaj, C.; Chanson, A.; Lecocq, S.; Lou""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,0,header,"J. Clin. Med. 2021, 10, 3882","[67.0, 103.0, 259.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +13,1,number,13 of 14,"[1062.0, 103.0, 1121.0, 125.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +13,2,reference_content,"7. Suh, C.H.; Yun, S.J.; Jin, W.; Lee, S.H.; Park, S.Y.; Park, J.S.; Ryu, K.N. Systematic review and meta-analysis of magnetic resonance imaging features for diagnosis of adhesive capsulitis of the sh","[66.0, 194.0, 1119.0, 240.0]",reference_item,0.85,"[""reference content label: 7. Suh, C.H.; Yun, S.J.; Jin, W.; Lee, S.H.; Park, S.Y.; Par""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,3,reference_content,"8. Song, K.D.; Kwon, J.W.; Yoon, Y.C.; Choi, S.-H. Indirect MR Arthrographic Findings of Adhesive Capsulitis. Am. J. Roentgenol. 2011, 197, W1105–W1109. [CrossRef]","[66.0, 240.0, 1123.0, 284.0]",reference_item,0.85,"[""reference content label: 8. Song, K.D.; Kwon, J.W.; Yoon, Y.C.; Choi, S.-H. Indirect ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,4,reference_content,"9. Mengiardi, B.; Pfirrmann, C.W.A.; Gerber, C.; Hodler, J.; Zanetti, M. Frozen Shoulder: MR Arthrographic Findings. Radiology 2004, 233, 486–492. [CrossRef] [PubMed]","[67.0, 286.0, 1122.0, 330.0]",reference_item,0.85,"[""reference content label: 9. Mengiardi, B.; Pfirrmann, C.W.A.; Gerber, C.; Hodler, J.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,5,reference_content,"10. Letevre-Colau, M.-M.; Drapé, J.-L.; Fayad, F.; Rannou, F.; Diche, T.; Minvielle, F.; Demaille-Wlodyka, S.; Mayoux-Benhamou, M.-A.; Fermanian, J.; Poiraudeau, S.; et al. Magnetic resonance imaging ","[67.0, 332.0, 1122.0, 400.0]",reference_item,0.85,"[""reference content label: 10. Letevre-Colau, M.-M.; Drap\u00e9, J.-L.; Fayad, F.; Rannou, F""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,6,reference_content,"11. Harris, G.; Bou-Haidar, P.; Harris, C. Adhesive capsulitis: Review of imaging and treatment: Adhesive capsulitis: Review of imaging and treatment. J. Med. Imaging Radiat. Oncol. 2013, 57, 633–643.","[68.0, 402.0, 1123.0, 446.0]",reference_item,0.85,"[""reference content label: 11. Harris, G.; Bou-Haidar, P.; Harris, C. Adhesive capsulit""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,7,reference_content,"12. Jung, J.-Y.; Jee, W.-H.; Chun, H.J.; Kim, Y.-S.; Chung, Y.G.; Kim, J.-M. Adhesive capsulitis of the shoulder: Evaluation with MR arthrography. Eur. Radiol. 2006, 16, 791–796. [CrossRef] [PubMed]","[68.0, 448.0, 1123.0, 491.0]",reference_item,0.85,"[""reference content label: 12. Jung, J.-Y.; Jee, W.-H.; Chun, H.J.; Kim, Y.-S.; Chung, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,8,reference_content,"13. Chi, A.S.; Kim, J.; Long, S.S.; Morrison, W.B.; Zoga, A.C. Non-contrast MRI diagnosis of adhesive capsulitis of the shoulder. Clin. Imaging 2017, 44, 46–50. [CrossRef]","[68.0, 494.0, 1123.0, 537.0]",reference_item,0.85,"[""reference content label: 13. Chi, A.S.; Kim, J.; Long, S.S.; Morrison, W.B.; Zoga, A.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,9,reference_content,"14. Ahn, K.-S.; Kang, C.H.; Kim, Y.; Jeong, W.-K. Diagnosis of adhesive capsulitis: Comparison of contrast-enhanced MRI with noncontrast-enhanced MRI. Clin. Imaging 2015, 39, 1061–1067. [CrossRef] [Pu","[69.0, 539.0, 1120.0, 584.0]",reference_item,0.85,"[""reference content label: 14. Ahn, K.-S.; Kang, C.H.; Kim, Y.; Jeong, W.-K. Diagnosis ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,10,reference_content,"15. Lee, K.H.; Park, H.J.; Lee, S.Y.; Youn, I.Y.; Kim, E.; Park, J.H.; Park, S.J. Adhesive Capsulitis of the Shoulder Joint: Value of Glenohumeral Distance on Magnetic Resonance Arthrography. J. Compu","[70.0, 586.0, 1123.0, 630.0]",reference_item,0.85,"[""reference content label: 15. Lee, K.H.; Park, H.J.; Lee, S.Y.; Youn, I.Y.; Kim, E.; P""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,11,reference_content,"16. Kim, K.C.; Rhee, K.J.; Shin, H.D. Adhesive capsulitis of the shoulder: Dimensions of the rotator interval measured with magnetic resonance arthrography. I. Shoulder Elb. Surg. 2009, 18, 437–442. [","[67.0, 633.0, 1123.0, 676.0]",reference_item,0.85,"[""reference content label: 16. Kim, K.C.; Rhee, K.J.; Shin, H.D. 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Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:1", + "page": 2, + "role": "noise", + "zone": "frontmatter_main_zone", + "render_default": false, + "snippet": "2 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:2", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "in various clinical scenarios and has multiple potential differential diagnoses ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:3", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Patients with AC typically complain of a gradual and progressive onset of pain, ", + "found_in_fulltext": true, + "fulltext_offset": 3336 + }, + { + "block_id": "p2:4", + "page": 2, + "role": "section_heading", + "zone": "frontmatter_side_zone", + "render_default": true, + "snippet": "2. Material and Methods 2.1. Study Group", + "found_in_fulltext": true, + "fulltext_offset": 4319 + }, + { + "block_id": "p2:6", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Our institutional review board approved this study, and all patients gave writte", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:7", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Patients with MRI contraindications, prior shoulder surgery, severe rotator cuff", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:8", + "page": 2, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2.2. Shoulder Function Assessment", + "found_in_fulltext": true, + "fulltext_offset": 4364 + }, + { + "block_id": "p2:9", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A modified CMS was applied to all patients by a senior radiologist just prior to", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:0", + "page": 3, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. Clin. Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:1", + "page": 3, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "3 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:2", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In addition to the modified CMS score, the pain duration was graded as follows:", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:3", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "1 = less than 6 weeks", + "found_in_fulltext": true, + "fulltext_offset": 4414 + }, + { + "block_id": "p3:4", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "2 = between 6 weeks and 3 months", + "found_in_fulltext": true, + "fulltext_offset": 4436 + }, + { + "block_id": "p3:5", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "3 = between 3 and 6 months", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:6", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "4 = between 6 months and 1 year", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:7", + "page": 3, + "role": "unknown_structural", + "zone": "", + "render_default": false, + "snippet": "5 = over 1 year", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:8", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The presence of diurnal pain, nocturnal pain, and nocturnal pain predominance we", + "found_in_fulltext": true, + "fulltext_offset": 4469 + }, + { + "block_id": "p3:9", + "page": 3, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2.3. Clinical Follow-Up", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:10", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A clinical follow-up was available in a sub-group of 49 patients with a mean age", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:11", + "page": 3, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2.4. Mri Examination", + "found_in_fulltext": true, + "fulltext_offset": 4572 + }, + { + "block_id": "p3:12", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "MRI examinations were performed with either a 1.5 T (105 patients) or a 3.0 T (2", + "found_in_fulltext": true, + "fulltext_offset": 4593 + }, + { + "block_id": "p3:13", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "All MRI examinations consisted of an axial and oblique sagittal fast spin-echo (", + "found_in_fulltext": true, + "fulltext_offset": 4810 + }, + { + "block_id": "p3:14", + "page": 3, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2.5. Image Analysis", + "found_in_fulltext": true, + "fulltext_offset": 5481 + }, + { + "block_id": "p3:15", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The images were retrospectively reviewed by two musculoskeletal radiologists wit", + "found_in_fulltext": true, + "fulltext_offset": 5501 + }, + { + "block_id": "p3:16", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The signal intensity of the IGHL on oblique coronal T2-weighted fat-saturated im", + "found_in_fulltext": true, + "fulltext_offset": 6019 + }, + { + "block_id": "p3:17", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "1: normal homogenous low signal intensity", + "found_in_fulltext": true, + "fulltext_offset": 6138 + }, + { + "block_id": "p3:18", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "2: partial or foci of signal hyperintensity", + "found_in_fulltext": true, + "fulltext_offset": 6180 + }, + { + "block_id": "p3:19", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "3: global signal hyperintensity", + "found_in_fulltext": true, + "fulltext_offset": 6224 + }, + { + "block_id": "p3:20", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "4: linear hyperintensity of the peri-articular soft tissues", + "found_in_fulltext": true, + "fulltext_offset": 6256 + }, + { + "block_id": "p4:0", + "page": 4, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. 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Statistical Analysis", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:3", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The R Development Core Team software (version 3.0.12013, R Foundation for Statis", + "found_in_fulltext": true, + "fulltext_offset": 7604 + }, + { + "block_id": "p6:4", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Linear regression analysis with the Pearson test was used to evaluate the correl", + "found_in_fulltext": true, + "fulltext_offset": 7894 + }, + { + "block_id": "p6:5", + "page": 6, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "3. Results", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:6", + "page": 6, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 1 shows demographic characteristics and modified CMS in the study populati", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:7", + "page": 6, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 1. Summary of patients' ages and clinical impairment items.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:8", + "page": 6, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
ACadhesive capsulitis
CHLcoracohumeral ligament
CMSConstant-Murlay Score
ETLecho-train length
ParameterMinimumMaximumMeanSt", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:9", + "page": 6, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 2. Summary of patients' pain characteristics.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:11", + "page": 6, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "$ ^{*} $ 22 data were missing because patients were not able to determine it.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:0", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. Clin. Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:1", + "page": 7, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "7 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:2", + "page": 7, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 3. Pain duration grade according to inferior glenohumeral ligament signal ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:3", + "page": 7, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
IGHL Signal IntensityPa", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:4", + "page": 7, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "IGHL: inferior glenohumeral ligament, results of pain duration score are present", + "found_in_fulltext": true, + "fulltext_offset": 8712 + }, + { + "block_id": "p7:5", + "page": 7, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 4. Summary of patients' MRI measurements.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:7", + "page": 7, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "Values are given in millimeters. IGHL: inferior glenohumeral ligament, CHL: cora", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:8", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "ICC was excellent in grading IGHL signal as low or high (0.96), and moderate whe", + "found_in_fulltext": true, + "fulltext_offset": 8881 + }, + { + "block_id": "p7:9", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Mobility scores were significantly different in patients with high IGHL signal i", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:10", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "For both readers, pain duration was significantly shorter in patients with high ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:11", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The glenoidal IGHL thickness was significantly correlated with activity limitati", + "found_in_fulltext": true, + "fulltext_offset": 9141 + }, + { + "block_id": "p7:12", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "CHL measurements are shown in Table 4. This ligament could not be measured confi", + "found_in_fulltext": true, + "fulltext_offset": 10319 + }, + { + "block_id": "p8:0", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. Clin. Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:1", + "page": 8, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "8 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:0", + "page": 9, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. Clin. Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:1", + "page": 9, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "9 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p9:4", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Concerning disease progression, 31 patients (13 men, 18 women, mean age $ 55 \\pm", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:0", + "page": 10, + "role": "noise", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "J. Clin. Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:1", + "page": 10, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "10 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:2", + "page": 10, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "$ (p = 0.2) $. For both readers, the presence of high IGHL signal intensity was ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:4", + "page": 10, + "role": "figure_caption_candidate", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "Figure 6. Box plot representing inferior glenohumeral ligament thickness (y-axis", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:5", + "page": 10, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "For both readers, there was no association between CMS modified global score, pa", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:0", + "page": 11, + "role": "noise", + "zone": "tail_nonref_hold_zone", + "render_default": false, + "snippet": "J. Clin. Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:1", + "page": 11, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "11 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:2", + "page": 11, + "role": "section_heading", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "4. Discussion", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p11:3", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Our study showed a significant correlation between high IGHL signal intensity an", + "found_in_fulltext": true, + "fulltext_offset": 11743 + }, + { + "block_id": "p11:4", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Unlike Anh et al. [26], we did not find any correlation between MRI findings and", + "found_in_fulltext": true, + "fulltext_offset": 14328 + }, + { + "block_id": "p11:5", + "page": 11, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "This study has limitations. Most importantly, AC diagnosis was confirmed neither", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:0", + "page": 12, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "J. Clin. Med. 2021, 10, 3882", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:1", + "page": 12, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "12 of 14", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:2", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "heterogeneous with various disease stages and clinical impairment levels; howeve", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:3", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In conclusion, two potentially useful MR biomarkers in patients with AC could be", + "found_in_fulltext": true, + "fulltext_offset": 15573 + }, + { + "block_id": "p12:4", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Supplementary Materials: The following are available online at https://www.mdpi.", + "found_in_fulltext": true, + "fulltext_offset": 16149 + }, + { + "block_id": "p12:5", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Author Contributions: Conceptualization, R.G. and P.A.G.T.; methodology, P.A.G.T", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:6", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Funding: This research received no external funding.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:7", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Institutional Review Board Statement: The study was conducted according to the g", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:8", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Informed Consent Statement: Written informed consent was obtained from all subje", + "found_in_fulltext": true, + "fulltext_offset": 16307 + }, + { + "block_id": "p12:10", + "page": 12, + "role": "sub_subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Abbreviations", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p12:11", + "page": 12, + "role": "media_asset", + "zone": "body_zone", + "render_default": true, + "snippet": "
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"p14:8", + "p14:9", + "p14:10", + "p14:11", + "p15:0", + "p15:1", + "p15:2", + "p15:3", + "p15:4", + "p15:5", + "p15:6", + "p15:7", + "p15:8", + "p15:9", + "p15:10", + "p15:11", + "p15:12", + "p15:13", + "p15:14", + "p15:15", + "p15:16", + "p15:17", + "p15:18", + "p15:19", + "p15:20", + "p15:21", + "p15:22", + "p17:0", + "p17:1", + "p17:2", + "p17:3", + "p17:4", + "p17:5", + "p17:6", + "p17:7", + "p17:8", + "p17:9", + "p17:10", + "p17:11", + "p17:12", + "p17:13", + "p17:14", + "p17:15", + "p17:16", + "p17:17", + "p17:18", + "p17:19", + "p17:20", + "p17:21", + "p17:22" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:15" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:16" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:17" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:18" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:19" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:21" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p17:22" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p18:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_018.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p18:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_018.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p18:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_018.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p18:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_018.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p18:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_018.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_017.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "object_ownership_error", + "severity": "major", + "block_ids": [], + "truth": "figure/table ownership should map captions and assets coherently", + "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", + "root_cause_hypothesis": "caption-to-asset grouping ambiguity", + "evidence": { + "annotated_page": null, + "artifact": "figure_table_ownership_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:8", + "p1:22", + "p1:23", + "p2:0", + "p2:1", + "p2:2", + "p2:3", + "p2:4", + "p3:0", + "p3:1", + "p3:2", + "p3:3", + "p3:4", + "p4:0", + "p4:1", + "p4:2" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/8K39NHUQ/audit_report.md b/audit/8K39NHUQ/audit_report.md new file mode 100644 index 00000000..b0832bb9 --- /dev/null +++ b/audit/8K39NHUQ/audit_report.md @@ -0,0 +1,38 @@ +# OCR Truth Audit Report - 8K39NHUQ + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17] +- Reviewed blocks: 180 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/8K39NHUQ/audit_scope.json b/audit/8K39NHUQ/audit_scope.json new file mode 100644 index 00000000..3f287400 --- /dev/null +++ b/audit/8K39NHUQ/audit_scope.json @@ -0,0 +1,1530 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 5, + 6, + 7, + 8, + 9, + 10, + 11, + 12, + 13, + 14, + 15, + 17 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p1:21", + "p1:22", + "p1:23", + "p5:4", + "p6:3", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p9:5", + "p9:6", + "p10:2", + "p10:3", + "p10:4", + "p10:5", + "p10:6", + "p10:10", + 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'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,1,header,biomedicines,"[147.0, 113.0, 397.0, 159.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,2,header_image,,"[1030.0, 109.0, 1119.0, 168.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,3,text,Article,"[66.0, 207.0, 131.0, 231.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair,"[66.0, 232.0, 1016.0, 311.0]",paper_title,0.8,"[""page-1 zone title_zone: Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Pr""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Jiahang Wu$^{1}$, Taijun Chen$^{1}$, Yingying Wang$^{1}$, Jiafan Bai$^{1}$, Chenwen Lao$^{1}$, Minyue Luo$^{1}$, Mingxia Chen$^{1}$, Wenzhen Peng$^{2}$, Wei Zhi$^{1}$, Jie Weng$^{1}$ and Jianxin Wang$","[65.0, 333.0, 1049.0, 387.0]",authors,0.8,"[""page-1 zone author_zone: Jiahang Wu$^{1}$, Taijun Chen$^{1}$, Yingying Wang$^{1}$, Ji""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text,"Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; 1992380956@163.com (J.W.","[327.0, 427.0, 1110.0, 538.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: Key Laboratory of Advanced Technologies of Materials, Minist""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,paragraph_title,check for updates,"[69.0, 781.0, 178.0, 818.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: check for updates""]",section_heading,0.5,body_zone,unknown_like,short_fragment,True,True +1,8,text,"2 Chengdu Yikeda Biotechnology Co., Ltd., Chengdu 610095, China; halishengwu@163.com","[327.0, 536.0, 998.0, 558.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2 Chengdu Yikeda Biotechnology Co., Ltd., Chengdu 610095, Ch""]",affiliation,0.8,body_zone,reference_like,reference_numeric_dot,True,True +1,9,text,"Citation: Wu, J.; Chen, T.; Wang, Y.; Bai, J.; Lao, C.; Luo, M.; Chen, M.; Peng, W.; Zhi, W.; Weng, J.; et al. Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect R","[66.0, 825.0, 293.0, 1038.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Wu, J.; Chen, T.; Wang, Y.; Bai, J.; Lao, C.; Luo,""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,10,text,"Academic Editors: Antonino Morabito and Mike Barbeck +Correspondence: jwang@swjtu.edu.cn; Tel.: +86-28-87634023","[67.0, 1052.0, 252.0, 1097.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic Editors: Antonino Morabito and Mike Barbeck\nCorresp""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,11,text,"g gy g +* Correspondence: jwang@swjtu.edu.cn; Tel.: +86-28-87634023","[327.0, 558.0, 795.0, 580.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: g gy g\n* Correspondence: jwang@swjtu.edu.cn; Tel.: +86-28-87""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,12,image,,"[69.0, 1313.0, 185.0, 1354.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,13,text,Publisher's Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[66.0, 1197.0, 307.0, 1289.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +1,14,text,"Received: 29 March 2022 +Accepted: 9 May 2022 +Published: 18 May 2022","[67.0, 1113.0, 227.0, 1183.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 29 March 2022\nAccepted: 9 May 2022\nPublished: 18 M""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,15,text,"Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66.0, 1362.0, 309.0, 1551.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2022 by the authors. Licensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,16,abstract,Abstract: The lack of vascular tissue and the low metabolism and biological activity of mature chondrocytes lead to the low regeneration ability of articular cartilage. People try to solve this proble,"[327.0, 608.0, 1123.0, 946.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,17,text,Keywords: piezoelectric effect; biomimetic hydrogel; antibacterial; cartilage tissue; tissue regeneration,"[327.0, 969.0, 1122.0, 995.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: piezoelectric effect; biomimetic hydrogel; antibac""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,18,paragraph_title,1. Introduction,"[329.0, 1069.0, 473.0, 1092.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,19,text,"Articular cartilage is one of the connective tissues in the skeletal system. However, due to the fact that cartilage is an avascular tissue, the metabolism and biological activity of mature chondrocyt","[325.0, 1100.0, 1124.0, 1199.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,text,"Although the known surgical treatment for cartilage disease has a certain effect, it cannot completely repair the damaged defect. Therefore, to improve the quality of treatment, it is necessary to see","[324.0, 1200.0, 1124.0, 1326.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,21,text,"Because of its good biocompatibility and low immune response, hydrogels are a promising biomaterial for osteochondral tissue engineering. Pulkkinen et al. demonstrated that type II collagen hydrogels ","[324.0, 1327.0, 1126.0, 1554.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,22,footer,"Biomedicines 2022, 10, 1165. https://doi.org/10.3390/biomedicines10051165","[67.0, 1625.0, 607.0, 1647.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,23,footer,https://www.mdpi.com/journal/biomedicines,"[777.0, 1625.0, 1122.0, 1648.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"Biomedicines 2022, 10, 1165","[68.0, 111.0, 258.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,2 of 19,"[1068.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,2,text,"and the surrounding host bone and the same thickness of the new cartilage as that of the host cartilage were realized at 12 weeks postoperatively [3]. However, traditional hydrogels lack the function ","[324.0, 193.0, 1124.0, 493.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Inspired by the piezoelectric effect of collagen in cartilage tissue [9,10], this work would focus on the design of a biomimetic hydrogel by introducing piezoelectric materials into hydrogel to endow ","[325.0, 493.0, 1125.0, 871.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Although PVA has been proven to be able to be used in the repair of osteochondral defects in previous work, due to its low biodegradability and bioactivity only pure PVA hydrogel cannot obtain good os","[324.0, 870.0, 1125.0, 1197.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,paragraph_title,2. Materials and Methods 2.1. Materials,"[328.0, 1217.0, 569.0, 1265.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods 2.1. Materials""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,6,footer,,"[329.0, 1243.0, 452.0, 1265.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,7,text,"Sodium chloride (NaCl, >98.0%), Dimethyl sulfoxide (DMSO, >98.0%), Silver nitrate (AgNO₃, 99%), Absolute ethanol (99%), Calcium nitrate tetrahydrate (Ca(NO₃)₂·4H₂O), Ammonium phosphate ((NH₄)₂HPO₄), A","[327.0, 1274.0, 1124.0, 1449.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,2.2. Preparation of Hydrogels,"[328.0, 1469.0, 575.0, 1494.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Preparation of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,text,"PVA/PVDF piezoelectric hydrogel was prepared using a two-step method. First, 60 mL DMSO and 40 mL distilled water were mixed into a solvent, and 7.5 g PVA and 7.5 g","[327.0, 1500.0, 1124.0, 1550.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"Biomedicines 2022, 10, 1165","[68.0, 111.0, 258.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header,3 of 19,"[1068.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,2,text,"PVDF were dissolved in this solvent. The mixture was stirred for 6 h at 92 °C until the suspension solution became homogeneous. Subsequently, the solution was poured into the mold, frozen, and thawed ","[327.0, 191.0, 1122.0, 294.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,2.3. Preparation of Nano-HA,"[328.0, 312.0, 572.0, 337.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Preparation of Nano-HA""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,4,text,"The synthesis of nano-HA was based on the method reported previously [16]. 11.8 g calcium nitrate tetrahydrate (Ca(NO₃)₂·4H₂O) was dissolved in 100 mL DD water, and 3.95 g ammonium phosphate ((NH₄)₂HP","[325.0, 344.0, 1125.0, 570.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,2.4. Preparation of Silver Nanowires,"[328.0, 589.0, 632.0, 613.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Preparation of Silver Nanowires""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,6,text,"The preparation method of silver nanowires (Ag-NWs) is based on the ethylene glycol system reported previously [17], and the specific operation process is as follows: 70 mL PVP (K30) glycol solution w","[326.0, 620.0, 1125.0, 847.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,paragraph_title,2.5. Preparation of Bi-Layer Hydrogel,"[328.0, 865.0, 643.0, 890.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Preparation of Bi-Layer Hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,8,text,The preparation process of the bi-layer hydrogel is as follows. The preparation method of osteogenic layer and chondrogenic layer is similar to that of single layer hydrogel; 0.6 g of Ag-NWs was added,"[325.0, 897.0, 1124.0, 1100.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,2.6. Characterization of Materials,"[329.0, 1117.0, 609.0, 1141.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Characterization of Materials""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,10,text,"The composite mechanism of the sample was analyzed using a Fourier transform infrared spectrometer (FT-IR, PerkinElmer, Waltham, MA, USA). The compressive stress of the hydrogels was measured by a uni","[326.0, 1149.0, 1124.0, 1503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"Biomedicines 2022, 10, 1165","[68.0, 111.0, 258.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,4 of 19,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,2,paragraph_title,2.7. Cytocompatibility,"[328.0, 191.0, 518.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Cytocompatibility""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,3,text,The cytocompatibility of the hydrogel samples was evaluated through the co-culture of L929 cells with PVA/HA hydrogel and PVA/PVDF/Ag/HA hydrogel. These L929 cells co-cultured with PBS were set as the,"[326.0, 224.0, 1124.0, 399.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,2.8. Hemolysis Assay,"[329.0, 418.0, 511.0, 442.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Hemolysis Assay""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,5,text,"The hydrogel samples with a diameter of 5 mm and a height of 2~3 mm were prepared. The rabbit blood was centrifuged at 1500 rpm for 15 min at 4 °C, rinsed with PBS, and the cycle was repeated three ti","[325.0, 448.0, 1125.0, 755.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,2.9. Degradation Experiment of Hydrogel,"[329.0, 770.0, 673.0, 796.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Degradation Experiment of Hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,7,text,The degradation test was performed in 30 mL PBS (pH = 7.4) or PBS/trypsin solution. The weighed samples were immersed in a certain medium and incubated in a thermostatic bath at 37 °C. At predetermine,"[326.0, 801.0, 1126.0, 979.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,paragraph_title,2.10. Antibacterial Test,"[328.0, 997.0, 526.0, 1020.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. Antibacterial Test""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,9,text,"Gram-positive S. aureus and Gram-negative E. coli were used to evaluate the antibacterial properties of the hydrogel samples. The hydrogel samples with 3~4 mm height, 10 mm diameter were used as the e","[327.0, 1029.0, 1125.0, 1332.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,paragraph_title,2.11. Animal Model and Histological Analysis,"[328.0, 1349.0, 713.0, 1374.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.11. Animal Model and Histological Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,11,text,"All surgical procedures and subsequent animal care were approved by Ethics Committee of State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Approval Code: SKLODLL2013A86; Approv","[326.0, 1380.0, 1124.0, 1558.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,"Biomedicines 2022, 10, 1165","[67.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,5 of 19,"[1069.0, 110.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,2,text,"the rabbit was shaved, sterilized using iodine solution, and draped in a sterile manner, followed by an arthrotomy of the knee joint performed by an anterior medial parapatellar incision, and an opera","[324.0, 192.0, 1125.0, 571.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,figure_title,Table 1. Cartilage Repair Assessment ICRS.,"[327.0, 593.0, 681.0, 619.0]",table_caption,0.9,"[""table prefix matched: Table 1. Cartilage Repair Assessment ICRS.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,4,table,"
Scoring ItemsIndex ParametersScore
Degree of Defect RepairComplete repair of defect depth4
75% repair o","[330.0, 626.0, 1121.0, 1329.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,5,text,"The H&E staining procedure is briefly described as follows: The tissue sections were incubated in the hematoxylin solution at 37 °C for 5 min, rinsed with water for 1 min to remove excess hematoxylin,","[326.0, 1360.0, 1123.0, 1485.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,The toluidine blue staining procedure is briefly described as follows: The tissue sections were incubated in 0.2% toluidine blue solution for 10 min and rinsed with water for 3 s.,"[326.0, 1486.0, 1124.0, 1561.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,0,header,"Biomedicines 2022, 10, 1165","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,6 of 19,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,2,figure_title,Table 2. Histological scoring system for evaluating osteochondral defects.,"[326.0, 192.0, 920.0, 215.0]",table_caption,0.9,"[""table prefix matched: Table 2. Histological scoring system for evaluating osteocho""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,3,table,"
Scoring ItemsIndex ParametersScore
(a) Overall Defects Evaluation
1. Percent Filling With Newly Formed Tissue","[325.0, 225.0, 1123.0, 1428.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,paragraph_title,2.12. Statistical Analysis,"[328.0, 1454.0, 541.0, 1480.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.12. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,5,text,"All data are presented as mean ± standard deviation. Student’s test was used to compare the data between two groups, and one-way analysis of variance (ANOVA) was used for statistical tests for compari","[326.0, 1487.0, 1124.0, 1564.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,0,header,"Biomedicines 2022, 10, 1165","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,7 of 19,"[1068.0, 110.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,2,text,"than 0.05, the difference was considered statistically significant. The displayed error bars represent the standard deviation (SD).","[326.0, 191.0, 1122.0, 243.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,paragraph_title,3. Results and Discussion 3.1. Optimization of PVA/PVDF Hydrogels,"[327.0, 262.0, 690.0, 314.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and Discussion 3.1. Optimization of PVA/PVDF Hydr""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,4,footer,,"[327.0, 288.0, 690.0, 314.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +7,5,text,"For materials used to repair osteochondral defects, we hope that they have certain piezoelectric properties to stimulate the activity of the cells, and that they also have certain mechanical propertie","[323.0, 320.0, 1125.0, 469.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Figure 1A. shows the FT-IR characteristic peaks of PVA and PVDF. For PVA, the peaks at 3337 cm⁻¹, 2943 cm⁻¹ and 1093 cm⁻¹ corresponded to the stretching vibration peak of -OH [18], the asymmetrical st","[323.0, 469.0, 1124.0, 848.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 1A. shows the FT-IR characteristic peaks of PVA and P""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +7,7,chart,,"[346.0, 868.0, 688.0, 1157.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,8,chart,,"[693.0, 870.0, 1033.0, 1150.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,9,chart,,"[335.0, 1156.0, 688.0, 1448.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,10,chart,,"[709.0, 1155.0, 1033.0, 1450.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,11,figure_title,Figure 1. FT-IR analysis and swelling behaviors of the hydrogels. (A) FI-IR spectra of pure PVA and PVDF. (B) FT-IR spectra of PVA/PVDF composite hydrogels. (C) Swelling curves of hydrogels in PBS buf,"[326.0, 1467.0, 1123.0, 1567.0]",figure_caption,0.92,"[""figure_title label: Figure 1. FT-IR analysis and swelling behaviors of the hydro""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,0,header,"Biomedicines 2022, 10, 1165","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 19,"[1068.0, 111.0, 1122.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,text,"The piezoelectric experimental results are shown in Figure 2. It can be seen that with the increase in the PVDF content in the hydrogel, the piezoelectric voltage of the materials increased from 0.08 ","[323.0, 192.0, 1125.0, 547.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,chart,,"[167.0, 567.0, 450.0, 791.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,4,chart,,"[454.0, 572.0, 740.0, 789.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,5,chart,,"[741.0, 573.0, 1025.0, 790.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,6,chart,,"[166.0, 801.0, 449.0, 1025.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,7,chart,,"[454.0, 801.0, 741.0, 1027.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,8,chart,,"[745.0, 797.0, 1024.0, 1011.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,Figure 2. Piezoelectric responses of PVA/PVDF composite hydrogels.,"[326.0, 1046.0, 887.0, 1071.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Piezoelectric responses of PVA/PVDF composite hydr""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,10,text,"Normally, we calculate the swelling rate by the change in mass, which is different from the swelling rate calculated by the change in volume. From the testing results of the swelling rate by the chang","[324.0, 1088.0, 1125.0, 1571.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,0,header,"Biomedicines 2022, 10, 1165","[68.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,9 of 19,"[1069.0, 110.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,text,capillary adsorption of water. This is why we didn’t observe a significant change in PVA volume during swelling. This means that swelling rate does not play a dominant role in the screening of composi,"[325.0, 191.0, 1124.0, 267.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"Based on the above experimental results, PVA15/PVDF15 hydrogel with good comprehensive properties was selected for the follow-up experimental study. Furthermore, we hoped to endow PVA/PVDF hydrogels w","[326.0, 267.0, 1124.0, 366.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"10 study the effect of Ag-NWs on the piezoelectric property of materials, we first investigated the changes in XRD diffraction peaks before and after adding Ag-NWs. For PVDF, the characteristic peaks ","[326.0, 365.0, 1123.0, 871.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +9,5,display_formula, $$ \mathrm{F}(\beta)=\frac{\mathrm{A}_{\beta}}{\left(\frac{\mathrm{K}_{\beta}}{\mathrm{K}_{\alpha}}\right)\mathrm{A}_{\alpha}+\mathrm{A}_{\beta}} $$ ,"[619.0, 867.0, 826.0, 931.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +9,6,formula_number,(1),"[1095.0, 879.0, 1120.0, 903.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +9,7,text,"In the formula, Aα and Aβ are the absorbance at 766 cm⁻¹ and 840 cm⁻¹, respectively, while Kα and Kβ are the absorption coefficients of α and β phases at the respective wavenumber, which are 6.1 × 10⁴","[327.0, 942.0, 1124.0, 1297.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,text,"Referring to the reported research results [22,27], in this study, we chose Ag doping amounts of 0.3%, 0.45%, and 0.6% to investigate the effect of Ag-NWs on piezoelectric properties. After adding Ag-","[326.0, 1297.0, 1124.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"Biomedicines 2022, 10, 1165","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,10 of 19,"[1062.0, 110.0, 1122.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,chart,,"[346.0, 196.0, 700.0, 490.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,3,chart,,"[713.0, 197.0, 1070.0, 486.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,4,chart,,"[341.0, 496.0, 583.0, 733.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,5,chart,,"[583.0, 505.0, 823.0, 733.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,6,chart,,"[822.0, 502.0, 1071.0, 735.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,7,figure_title,"Figure 3. (A) XRD patterns of PVA/PVDF and PVA/PVDF/Ag hydrogels. (B) FT-IR spectra of PVA/PVDF and PVA/PVDF/Ag hydrogels. (C–E) Piezoelectric responses of PVA/PVDF hydrogels with 0.3% (C), 0.45% (D),","[327.0, 747.0, 1124.0, 824.0]",figure_caption,0.92,"[""figure_title label: Figure 3. (A) XRD patterns of PVA/PVDF and PVA/PVDF/Ag hydro""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +10,8,paragraph_title,3.2. Swelling Behaviors of Hydrogels,"[328.0, 838.0, 635.0, 864.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Swelling Behaviors of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +10,9,text,"In order to further allow the composite to better match the cartilage modulus, we used different concentrations of ethanol to dehydrate the composite, adjusted its compression modulus, removed the res","[324.0, 868.0, 1125.0, 1149.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,chart,,"[335.0, 1169.0, 707.0, 1474.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,11,chart,,"[714.0, 1171.0, 1097.0, 1466.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,12,figure_title,"Figure 4. (A) Swelling curves and (B) swelling rates of the PVA/PVDF/Ag composite hydrogels dehydrated with different concentrations of ethanol in PBS buffer solution (37 °C, pH = 7.4).","[327.0, 1488.0, 1122.0, 1540.0]",figure_caption,0.92,"[""figure_title label: Figure 4. (A) Swelling curves and (B) swelling rates of the ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,0,header,"Biomedicines 2022, 10, 1165","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,number,11 of 19,"[1061.0, 111.0, 1122.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,paragraph_title,3.3. Rheological Studies of Hydrogels,"[327.0, 191.0, 639.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Rheological Studies of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +11,3,text,"The dynamic mechanical properties of PVA15/PVDF15/Ag hydrogels after dehydration using different ethanol concentrations are shown in Figure 5A. In the range of 0.1 to 100 Hz, the hydrogel had a high s","[325.0, 222.0, 1125.0, 551.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,chart,,"[165.0, 569.0, 450.0, 803.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,5,chart,,"[448.0, 573.0, 737.0, 803.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,6,chart,,"[739.0, 573.0, 1031.0, 801.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,7,figure_title,B,"[169.0, 819.0, 194.0, 848.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,8,image,,"[214.0, 816.0, 405.0, 1016.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,9,image,,"[407.0, 816.0, 693.0, 1015.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,10,image,,"[697.0, 817.0, 979.0, 1013.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,11,chart,,"[163.0, 1030.0, 443.0, 1276.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,12,figure_title,D,"[452.0, 1030.0, 476.0, 1057.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,13,chart,,"[449.0, 1033.0, 737.0, 1272.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,14,chart,,"[744.0, 1029.0, 1022.0, 1278.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,15,figure_title,"Figure 5. Dynamic rheology behaviors and mechanical properties of the PVA/PVDF/Ag composite hydrogels. (A) G′, G′′ and tan δ change with frequency. T = 25 °C, strain = 1%. (B) Compression process imag","[323.0, 1298.0, 1124.0, 1452.0]",figure_caption,0.92,"[""figure_title label: Figure 5. Dynamic rheology behaviors and mechanical properti""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,16,paragraph_title,3.4. Mechanical Properties of Hydrogels,"[328.0, 1461.0, 660.0, 1487.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Mechanical Properties of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +11,17,text,"The compressive property of the materials dehydrated with different ethanol concentrations is shown in Figure 5B–D, which shows typical nonlinear viscoelastic behavior. Therefore, the compressive modu","[326.0, 1494.0, 1126.0, 1570.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,0,header,"Biomedicines 2022, 10, 1165","[67.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,12 of 19,"[1062.0, 110.0, 1122.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,text,"portion of the stress-strain curve (strain 0–15%). It can be seen that with the increase in ethanol concentration, the compressive modulus of the hydrogel increased from 0.074 MPa to 0.703 MPa, which ","[324.0, 192.0, 1123.0, 418.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,text,"The compression and recovery properties of hydrogel, which were closest to the natural modulus of cartilage. The results showed that after 9 cycles, the compression modulus of the hydrogel was still s","[325.0, 418.0, 1125.0, 594.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,paragraph_title,3.5. Morphology Analysis,"[328.0, 612.0, 548.0, 638.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Morphology Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,5,text,"Figure 6A,B shows the SEM images of silver nanowires and PVA15%/PVDF15%/Ag hydrogels. It can be seen that the length of the Ag-NWs obtained was about 5–15 μm. At the same time, the as-obtained hydroge","[325.0, 644.0, 1125.0, 873.0]",figure_caption,0.9,"[""figure caption candidate (body narrative): Figure 6A,B shows the SEM images of silver nanowires and PVA""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +12,6,figure_title,A,"[165.0, 901.0, 189.0, 929.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,7,figure_title,B,"[455.0, 896.0, 477.0, 921.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,8,image,,"[166.0, 896.0, 1026.0, 1399.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +12,9,figure_title,C,"[739.0, 899.0, 762.0, 926.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,10,figure_title,Figure 6. (A) SEM images of silver nanowires. (B) SEM images of PVA/PVDF/Ag composite hydrogels. (C–F) EDS mapping images of double-layer hydrogel. (C–F) have the same scale as (B).,"[325.0, 1422.0, 1120.0, 1474.0]",figure_caption,0.92,"[""figure_title label: Figure 6. (A) SEM images of silver nanowires. (B) SEM images""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +12,11,paragraph_title,3.6. Cell Compatibility of Hydrogels,"[327.0, 1488.0, 629.0, 1513.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.6. Cell Compatibility of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,12,text,"Based on the results of compression, piezoelectric and swelling properties of piezoelectric composite hydrogels, we finally chose 70% PVA15/PVDF15/Ag0.3 dehydrated","[326.0, 1519.0, 1125.0, 1571.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,0,header,"Biomedicines 2022, 10, 1165","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,number,13 of 19,"[1062.0, 110.0, 1122.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,2,text,"composite hydrogel as the experimental group for subsequent biological evaluation, because its comprehensive properties are best matched with natural cartilage. We then studied the cell compatibility ","[323.0, 192.0, 1126.0, 521.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,image,,"[344.0, 540.0, 1092.0, 1074.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,4,chart,,"[845.0, 710.0, 1092.0, 896.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,5,chart,,"[849.0, 893.0, 1092.0, 1074.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,6,figure_title,"Figure 7. Cytotoxicity and antibacterial properties of PVA/PVDF/HA/Ag composite hydrogels. (A) Proliferative activity of L929 cells co-cultured with PVA/PVDF/HA/Ag composite hydrogels at 1 day, 3 days","[325.0, 1094.0, 1126.0, 1325.0]",figure_caption,0.92,"[""figure_title label: Figure 7. Cytotoxicity and antibacterial properties of PVA/P""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +13,7,paragraph_title,3.7. Antibacterial Properties of Hydrogels,"[328.0, 1337.0, 674.0, 1362.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.7. Antibacterial Properties of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +13,8,text,"Further, we evaluated the antibacterial properties of piezoelectric composite hydrogels at the macroscopic level by using the plate counting method. Because the plate counting method is better than th","[326.0, 1369.0, 1126.0, 1572.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,0,header,"Biomedicines 2022, 10, 1165","[67.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,1,number,14 of 19,"[1062.0, 110.0, 1122.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +14,2,text,"the culture of both Escherichia coli and Staphylococcus aureus. Through quantitative calculation, the inhibition rates of piezoelectric hydrogel on two kinds of bacteria reached over 95%, indicating t","[323.0, 192.0, 1125.0, 470.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,3,paragraph_title,3.8. Hemocompatibility Assay,"[328.0, 488.0, 582.0, 513.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.8. Hemocompatibility Assay""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +14,4,text,"We further used hemolysis to determine the blood compatibility of PVA/HA hydrogel and PVA15/PVDF15/Ag0.3 hydrogel, and the results are shown in Figure 8A,B. It can be seen that both hydrogels had almo","[324.0, 518.0, 1124.0, 672.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,figure_title,A,"[173.0, 693.0, 200.0, 722.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +14,6,chart,,"[203.0, 692.0, 594.0, 1027.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,7,chart,,"[592.0, 696.0, 1021.0, 1022.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,8,chart,,"[165.0, 1033.0, 593.0, 1372.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,9,chart,,"[595.0, 1036.0, 1019.0, 1373.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,10,figure_title,"Figure 8. (A) Photos of the hemolysis assay of composite hydrogels. (B) Hemolysis rate of the composite hydrogels. (C,D) Degradation rate of composite hydrogels in PBS buffer solution (pH = 7.4) and i","[326.0, 1395.0, 1124.0, 1473.0]",figure_caption,0.92,"[""figure_title label: Figure 8. (A) Photos of the hemolysis assay of composite hyd""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +14,11,text,"Figure 8C,D shows the results of in vitro degradation of hydrogel materials. It can be seen that the material basically did not degrade very well in the environment of both PBS buffer (pH = 7.4) and t","[326.0, 1490.0, 1124.0, 1569.0]",figure_caption,0.9,"[""figure prefix matched: Figure 8C,D shows the results of in vitro degradation of hyd"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +15,0,header,"Biomedicines 2022, 10, 1165","[67.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,header,15 of 19,"[1062.0, 110.0, 1122.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +15,2,text,"polymer materials is that water molecules and enzymes cut off the polymer molecular chain, leading to the degradation of the materials [35,36]. In this experiment, the degradation rate of PVA remained","[324.0, 192.0, 1125.0, 368.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,3,paragraph_title,3.9. General Observation and Histological Analysis of Osteochondral Repair,"[327.0, 387.0, 954.0, 412.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.9. General Observation and Histological Analysis of Osteoc""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +15,4,text,"It can be seen from Figure 9A,B that there is still obvious depression in the defect of blank group, and there is basically no repair effect. In the PVA/HA hydrogel group, there was a clear difference","[324.0, 416.0, 1125.0, 848.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,5,figure_title,A,"[166.0, 893.0, 184.0, 915.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,6,figure_title,PVA/HA,"[345.0, 869.0, 413.0, 889.0]",figure_caption,0.85,"[""figure_title label: PVA/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,7,figure_title,PVA/PVDF/Ag/HA,"[437.0, 869.0, 581.0, 889.0]",figure_caption,0.85,"[""figure_title label: PVA/PVDF/Ag/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,8,image,,"[168.0, 868.0, 574.0, 1148.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,9,figure_title,B,"[165.0, 1022.0, 185.0, 1044.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,10,figure_title,Blank,"[643.0, 870.0, 696.0, 890.0]",figure_caption,0.85,"[""figure_title label: Blank""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,11,figure_title,C,"[587.0, 891.0, 604.0, 909.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,12,figure_title,PVA/HA,"[768.0, 870.0, 843.0, 890.0]",figure_caption,0.85,"[""figure_title label: PVA/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,13,image,,"[598.0, 882.0, 739.0, 1111.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,14,image,,"[744.0, 892.0, 880.0, 1114.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,15,figure_title,D,"[589.0, 1118.0, 605.0, 1137.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,16,figure_title,PVA/PVDF/Ag/HA,"[878.0, 869.0, 1033.0, 891.0]",figure_caption_candidate,0.85,"[""figure_title label: PVA/PVDF/Ag/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +15,17,chart,,"[163.0, 1160.0, 373.0, 1327.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,18,chart,,"[372.0, 1160.0, 586.0, 1328.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,19,image,,"[596.0, 1114.0, 740.0, 1330.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,20,image,,"[744.0, 1122.0, 880.0, 1328.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,21,image,,"[884.0, 881.0, 1027.0, 1323.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,22,figure_title,"Figure 9. (A) Osteochondral defect model in rabbits. (B) Macroscopic images of knees repaired after 12 weeks (C,D). Histological analysis of the repaired knees after 12 weeks. (C) Toluidine blue stain","[326.0, 1351.0, 1126.0, 1504.0]",figure_caption,0.92,"[""figure_title label: Figure 9. (A) Osteochondral defect model in rabbits. (B) Mac""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +16,0,header,"Biomedicines 2022, 10, 1165","[68.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,1,header,16 of 19,"[1062.0, 111.0, 1122.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +16,2,text,"Further, we evaluated the formation of osteochondral tissues as well as the integration of materials and host tissues at the defects by H&E and toluidine blue staining of histological sections at the ","[323.0, 191.0, 1125.0, 721.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,3,text,"In addition, we measured the size of the implants and found that the height of the implants at 12 weeks after implantation was generally less than that before implantation. We speculated that the redu","[325.0, 719.0, 1125.0, 970.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,4,text,"In general, the piezoelectric-effect-enhanced tissue regeneration ability has been seen, and the piezoelectric-effect-enhanced degradation was also observed in our present PVA material system, showing","[325.0, 971.0, 1124.0, 1072.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,5,paragraph_title,4. Conclusions,"[329.0, 1091.0, 471.0, 1114.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Conclusions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +16,6,text,"In this study, a composite hydrogel with piezoelectric and antibacterial properties was prepared, and these properties were enhanced by introducing silver nanowires. The mechanical and swelling proper","[325.0, 1120.0, 1124.0, 1428.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,0,header,"Biomedicines 2022, 10, 1165","[68.0, 111.0, 259.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,1,number,17 of 19,"[1062.0, 110.0, 1122.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +17,2,text,"Author Contributions: Conceptualization, J.W. (Jiahang Wu) and J.W. (Jianxin Wang); Formal analysis, J.W. (Jiahang Wu) and Y.W. (Yingying Wang); Funding acquisition, J.W. (Jianxin Wang); Investigation","[325.0, 194.0, 1125.0, 382.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,support_like,none,True,True +17,3,text,Funding: This work was founded by the National Natural Science Foundation of China [No.31370966] and the National Key Technologies R&D Program of China [2016YFC1102001].,"[326.0, 392.0, 1124.0, 440.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,4,text,"Institutional Review Board Statement: The animal study protocol was approved by the Ethics Committee of State Key Laboratory of Oral Diseases, West China Hospital of Stomatology; Approval Code: SKLODL","[326.0, 451.0, 1123.0, 522.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,5,text,Data Availability Statement: Not applicable.,"[328.0, 533.0, 695.0, 557.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,6,text,Acknowledgments: The authors thank the Committee of National Natural Science Foundation of China and the National Key Technologies R&D Program of China for their support. We thank Wenzhen Peng of Chen,"[326.0, 569.0, 1123.0, 640.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,text,"Conflicts of Interest: The Cytocompatibility test platform was kindly provided by Chengdu Yikeda Biotechnology Co., Ltd. (Chengdu, China) All authors acknowledged and decided to publish the results. T","[326.0, 651.0, 1122.0, 722.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +17,8,paragraph_title,References,"[67.0, 742.0, 175.0, 765.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +17,9,reference_content,"1. Gan, S.C.; Lin, W.N.; Zou, Y.L.; Xu, B.; Zhang, X.; Zhao, J.H.; Rong, J.H. Nano-hydroxyapatite enhanced double network hydrogels with excellent mechanical properties for potential application in ca","[66.0, 772.0, 1122.0, 838.0]",reference_item,0.85,"[""reference content label: 1. Gan, S.C.; Lin, W.N.; Zou, Y.L.; Xu, B.; Zhang, X.; Zhao,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,10,reference_content,"2. Man, Z.T.; Hu, X.Q.; Liu, Z.L.; Huang, H.J.; Meng, Q.Y.; Zhang, X.; Dai, L.H.; Zhang, J.Y.; Fu, X.; Duan, X.N.; et al. Transplantation of allogenic chondrocytes with chitosan hydrogel-demineralized","[66.0, 842.0, 1123.0, 908.0]",reference_item,0.85,"[""reference content label: 2. Man, Z.T.; Hu, X.Q.; Liu, Z.L.; Huang, H.J.; Meng, Q.Y.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,11,reference_content,"3. Zhu, X.B.; Chen, T.J.; Feng, B.; Weng, J.; Duan, K.; Wang, J.X. A biomimetic bacterial cellulose-enhanced double-network hydrogel with excellent mechanical properties applied for the osteochondral ","[66.0, 911.0, 1122.0, 976.0]",reference_item,0.85,"[""reference content label: 3. Zhu, X.B.; Chen, T.J.; Feng, B.; Weng, J.; Duan, K.; Wang""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,12,reference_content,"4. Pulkkinen, H.J.; Tiitu, V.; Valonen, P.; Jurvelin, J.S.; Lammi, M.J.; Kiviranta, I. Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo. Osteoarthr. Carti","[66.0, 980.0, 1123.0, 1024.0]",reference_item,0.85,"[""reference content label: 4. Pulkkinen, H.J.; Tiitu, V.; Valonen, P.; Jurvelin, J.S.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,13,reference_content,"5. Park, S.H.; Seo, J.Y.; Park, J.Y.; Ji, Y.B.; Kim, K.; Choi, H.S.; Choi, S.; Kim, J.H.; Min, B.M.; Kim, M.S. 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Piezoelectric mate""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,18,reference_content,"10. Ribeiro, C.; Sencadas, V.; Correia, D.M.; Lanceros-Méndez, S. Piezoelectric polymers as biomaterials for tissue engineering applications. Colloids Surf. B. 2015, 136, 46–55. [CrossRef]","[67.0, 1256.0, 1122.0, 1301.0]",reference_item,0.85,"[""reference content label: 10. Ribeiro, C.; Sencadas, V.; Correia, D.M.; Lanceros-M\u00e9nde""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,19,reference_content,"11. Feng, J.Q.; Yuan, H.P.; Zhang, X.D. Promotion of osteogenesis by a piezoelectric biological ceramic. Biomaterials 1997, 18, 1531–1534. [CrossRef]","[68.0, 1302.0, 1123.0, 1345.0]",reference_item,0.85,"[""reference content label: 11. Feng, J.Q.; Yuan, H.P.; Zhang, X.D. Promotion of osteoge""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,20,reference_content,"12. Ma, B.J.; Liu, F.; Li, Z.; Duan, J.Z.; Kong, Y.; Hao, M.; Ge, S.H.; Jiang, H.D.; Liu, H. Piezoelectric nylon-11 nanoparticles with ultrasound assistance for high-efficiency promotion of stem cell ","[68.0, 1348.0, 1122.0, 1414.0]",reference_item,0.85,"[""reference content label: 12. Ma, B.J.; Liu, F.; Li, Z.; Duan, J.Z.; Kong, Y.; Hao, M.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,21,reference_content,"13. Bichara, D.A.; Zhao, X.; Bodugoz-Senturk, H.; Ballyns, F.P.; Oral, E.; Randolph, M.A.; Bonassar, L.J.; Gill, T.J.; Muratoglu, O.K. Porous poly(vinyl alcohol)-hydrogel matrix-engineered biosyntheti","[67.0, 1417.0, 1122.0, 1483.0]",reference_item,0.85,"[""reference content label: 13. Bichara, D.A.; Zhao, X.; Bodugoz-Senturk, H.; Ballyns, F""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,22,reference_content,"14. Bi, S.C.; Wang, P.J.; Hu, S.H.; Li, S.K.; Pang, J.H.; Zhou, Z.Z.; Sun, G.H.; Huang, L.; Cheng, X.J.; Xing, S.C.; et al. Construction of physical-crosslink chitosan/PVA double-network hydrogel with","[66.0, 1486.0, 1123.0, 1553.0]",reference_item,0.85,"[""reference content label: 14. Bi, S.C.; Wang, P.J.; Hu, S.H.; Li, S.K.; Pang, J.H.; Zh""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,0,header,"Biomedicines 2022, 10, 1165","[67.0, 111.0, 259.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +18,1,number,18 of 19,"[1061.0, 111.0, 1122.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +18,2,reference_content,"15. Park, H.-H.; Ko, S.-C.; Oh, G.-W.; Jang, Y.-M.; Kim, Y.-M.; Park, W.S.; Choi, I.-W.; Jung, W.-K. 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Histological scoring system for evaluating osteochondral defects.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:4", + "page": 6, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2.12. Statistical Analysis", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:5", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "All data are presented as mean ± standard deviation. 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"reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p18:20", + "page": 18, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p18:21", + "page": 18, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p18:22", + "page": 18, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p18:23", + "page": 18, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p19:0", + "page": 19, + "role": "noise", + "zone": "", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p19:1", + "page": 19, + "role": "noise", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p19:2", + "page": 19, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p19:3", + "page": 19, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + } + ] + } +} \ No newline at end of file diff --git a/audit/A6IC2SIK/audit_report.json b/audit/A6IC2SIK/audit_report.json index 92a9564d..b3b7964d 100644 --- a/audit/A6IC2SIK/audit_report.json +++ b/audit/A6IC2SIK/audit_report.json @@ -5,35 +5,35 @@ "focus": [], "artifact_fingerprint": { "result_json_hash": "sha256:e08b4e8eb5c0eeaad36605b66381395ca6813d3c957e7c2f5734ea48ed958933", - "meta_json_hash": "sha256:90a75b1559ca2df9245772157b643498acf3d92b498dc8294a8a87b24165cc39", + "meta_json_hash": "sha256:da9fa1b02017a213f50ef26fcbfca30144771d8fee93ef224dcec44773010ad2", "blocks_raw_hash": "sha256:7bbc2b269e5782b0f2fde29a6fc4a038720c832b14126d49170ef35e36d80f21", - "structured_blocks_hash": "sha256:872960c4b42d7b70bdbc3de2f7476e453db78bf2c1e1df7ca56812c2b9f9f51c", - "document_structure_hash": "sha256:a48c141ba136383c147a12ced7154ec63adb8ae65116e901f0869dc9f9105d62", - "figure_inventory_hash": "sha256:615256e374050b7ebc55719a19c83fbea0a0ff1542f54bb2033320890dd3828e", - "table_inventory_hash": "sha256:698628932e58f37a6a7e36e93bfd17df4dde76b302adcd74dd397495be0d521a", - "reader_figures_hash": "sha256:487f7d76bcd916e164ff9b9b7c63cbc8ebb77eb47c51564d904f4e8ac9397eb2", - "resolved_metadata_hash": "sha256:899e36622dd0044ed511a55cfad880dd0f47bd6d861e9ca956839cc4992da217", - "fulltext_hash": "sha256:583c2528d1f47c939cdbf73797067be048e0c5b1e41e45f2a02964b16ac4d343", - "block_trace_hash": "sha256:13556a1475fa8ab59fdf4ab7d9a4de187cb69d87a20daa36bc6717dfadfe44e3", + "structured_blocks_hash": "sha256:b9d1d5c2a6c25202a880c64b97a90a3201f7dcd4e262dcb06e471e344ecbdf38", + "document_structure_hash": "sha256:2574d9f0e057a0a449fc6feb4f9fb7ccbff9b5ffebd1487110272d167b5a6e13", + "figure_inventory_hash": "sha256:94e5be95e0bf8832688a9ed292d0466b24e817283253f04f6766da59548abc76", + "table_inventory_hash": "sha256:c89b88786233e176745261067b04ed15909c03b29a736c20253b43949202fcda", + "reader_figures_hash": "sha256:0670ad40677c0ea3c785a8e227b04bfcf52126c590ed58b4e3a2ef34bcb8a8c0", + "resolved_metadata_hash": "sha256:bae5b1e6361ceb91e7103fa0dc76da6669431dd84239e8d4311a03bc08e20ed3", + "fulltext_hash": "sha256:3f93b3682992ac3596636a9572e52f2510fc235c801da45d274710a0e57a108a", + "block_trace_hash": "sha256:730dcad5e985a3644bd102fd6e3a2b9bee933f61f7b946c184759a3a3e33fe11", "annotated_pages": { - "page_001.png": "sha256:0a329e4491144e1ce69fd2fe957a4da5e6d98cda66935a96a901465c6b2c74c3", - "page_002.png": "sha256:f87666c4cfea345cee696314182c368589e16ce21e3c4cab3ef6dec2265af8a4", + "page_001.png": "sha256:cb5e51b4aadcf655c427779856db659d6493e89930c7ccaaed18ddd94cee3feb", + "page_002.png": "sha256:357ab4f0adf915473b7c47e0fab3c23f578aa80fa66ed84b0025ca2a0d0e83d9", "page_003.png": "sha256:fa5ea48de16d1c1528929d0798ba6a34e55f3f66f4458a1b6fa08e4c5ec66f91", "page_004.png": "sha256:44c0a9393195e017819c5685c543371b87bc6f92a1be75e43f4785fb656b90fd", - "page_005.png": "sha256:807b970682f1f0ba78ecd514481431aa662847bcf590ea41e66d613685f3a13f", + "page_005.png": "sha256:50b638c50b4d02c7994432accf0e15a1250b6415f085d0a78b2eb1deb4da75c7", "page_006.png": "sha256:c8bf067de9be61bdbc36ae5883f0b0a1bb54fd9e98914865763627d31e992651", "page_007.png": "sha256:5411ff142be611e24811b9eda29c6a4f693a45e0b0613e2d4bffd871d18c8742", - "page_008.png": "sha256:68dd9402f7d2c5414424d2ca08509aa791ef4bfa3925443191849d2c4e212fe3", + "page_008.png": "sha256:7c25a2a623a23e5b1bd9dbc1d6a8cfe7ffcf0938c534440d5737f9e92470f191", "page_009.png": "sha256:32f6e210a2eb71e0afcc4bf7ccca72ee3bfa0cf1c65c00c0f8bc77deb9d92125", "page_010.png": "sha256:ad3c2be2a2627d1bb736508535ab513a98e169686ecd738efc767fa213aabaa3", - "page_011.png": "sha256:6b0525d3a0bfaeaf04f413a35ec27c46f5547e27c7d6a03a978d6224098e64f7", + "page_011.png": "sha256:49415f8e8884c56f45cf7abdd13779de5e219899eb8f8bfc80486da29262dcdb", "page_012.png": "sha256:b50384774f164e656fa06039bf8efcfefb00a9a86e8cdfaff79bb4090ac9047c", "page_013.png": "sha256:8b9d5c6a87cc7ee91924b125cde1c4fe789e3f7fcc669aa14ef33aafdfd9d51d", "page_014.png": "sha256:b8dcebc70e3416d487f0e45da636a562e916c74f11267aa1301babb5774a0e42", "page_015.png": "sha256:6ce4fb1e2792cb54b82ab09b2c8c8d7057711feba58e49c36e91df54307e8f69", - "page_016.png": "sha256:144c5413f6af6fe6e61063210e52059fc68a41e8b407127ad2635eba858dc1f1", + "page_016.png": "sha256:c4f773f083804c1b55c9b09d5fa5eed820d253b3821ec692c495a41c72308943", "page_017.png": "sha256:bb99218198b1ba495aa2bc977f3b52f0693c4ac0cc5f353f8d09e5df737b9a3f", - "page_018.png": "sha256:b288291b4169b3dc5798f136b6b51e1c695c73c8ad7b104bb3f9063b1f414f1e", + "page_018.png": "sha256:12108f6cba2309ca7746e4b943a1b8535b333f7db9ef15f6180b569688509cf7", "page_019.png": "sha256:3c549c87560fc482a640a93f6cf46a762014bdfd1c8958af8c81959d4f1df225", "page_020.png": "sha256:c35038fe1fbd5b4ca46e7602dc158b231529d80e2d57c79afa8135f71c70a61d", "page_021.png": "sha256:8499f27388828c2d6fc89e7a54192f2c76c9d189c873a8dd69b8952b24ff7461", @@ -262,283 +262,15 @@ ], "findings": [ { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:2" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:3" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:4" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:5" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:6" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:7" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:8" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:9" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:10" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:11" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:12" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:13" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:14" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:15" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:16" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:17" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:18" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p19:19" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_019.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p20:0" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_020.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p20:1" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_020.png", - "artifact": "reference_span_audit.json" + "annotated_page": "annotated_pages/page_008.png", + "artifact": "page_risk_summary.json" } }, { @@ -563,20 +295,20 @@ "p2:0", "p2:1", "p2:2", + "p2:3", "p2:4", "p2:5", + "p2:6", "p2:8", "p3:0", + "p3:2", + "p3:3", "p4:0", + "p4:2", "p5:0", "p5:3", - "p6:0", - "p6:7", - "p6:9", - "p7:0", - "p7:6", - "p7:8", - "p7:9" + "p5:6", + "p6:0" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/A6IC2SIK/audit_report.md b/audit/A6IC2SIK/audit_report.md index b1764c33..0448a477 100644 --- a/audit/A6IC2SIK/audit_report.md +++ b/audit/A6IC2SIK/audit_report.md @@ -7,26 +7,7 @@ ## Findings -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output diff --git a/audit/A6IC2SIK/audit_scope.json b/audit/A6IC2SIK/audit_scope.json index 15dcd57d..92c2d6fc 100644 --- a/audit/A6IC2SIK/audit_scope.json +++ b/audit/A6IC2SIK/audit_scope.json @@ -47,6 +47,7 @@ "p8:4", "p8:7", "p8:8", + "p8:9", "p9:2", "p9:3", "p10:2", @@ -55,7 +56,6 @@ "p11:3", "p11:4", "p11:5", - "p11:6", "p11:7", "p12:2", "p12:3", @@ -70,7 +70,6 @@ "p15:4", "p15:5", "p15:6", - "p16:2", "p16:3", "p16:7", "p16:9", @@ -83,9 +82,6 @@ "p18:3", "p18:4", "p18:5", - "p18:8", - "p18:9", - "p18:10", "p24:1", "p24:2", "p24:3", @@ -111,8 +107,7 @@ "block_id": "p1:1", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -515,6 +510,21 @@ "truth_reference_membership" ] }, + { + "block_id": "p8:9", + "page": 8, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, { "block_id": "p9:2", "page": 9, @@ -635,21 +645,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:6", - "page": 11, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:7", "page": 11, @@ -860,21 +855,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p16:2", - "page": 16, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p16:3", "page": 16, @@ -1055,51 +1035,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p18:8", - "page": 18, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p18:9", - "page": 18, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p18:10", - "page": 18, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p24:1", "page": 24, @@ -1185,7 +1120,7 @@ { "page": 8, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 5 }, { "page": 9, @@ -1200,7 +1135,7 @@ { "page": 11, "must_review_page": true, - "required_block_count": 5 + "required_block_count": 4 }, { "page": 12, @@ -1220,7 +1155,7 @@ { "page": 16, "must_review_page": true, - "required_block_count": 5 + "required_block_count": 4 }, { "page": 17, @@ -1230,7 +1165,7 @@ { "page": 18, "must_review_page": true, - "required_block_count": 8 + "required_block_count": 5 }, { "page": 24, diff --git a/audit/A6IC2SIK/block_coverage_summary.json b/audit/A6IC2SIK/block_coverage_summary.json index dbf6aa97..c3fc33fe 100644 --- a/audit/A6IC2SIK/block_coverage_summary.json +++ b/audit/A6IC2SIK/block_coverage_summary.json @@ -84,7 +84,7 @@ "block_id": "p1:1", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", "bbox": [ 79.0, @@ -384,7 +384,7 @@ "block_id": "p2:2", "page": 2, "raw_label": "text", - "role": "non_body_insert", + "role": "authors", "zone": "body_zone", "bbox": [ 327.0, @@ -404,7 +404,7 @@ "block_id": "p2:3", "page": 2, "raw_label": "text", - "role": "frontmatter_noise", + "role": "affiliation", "zone": "frontmatter_side_zone", "bbox": [ 174.0, @@ -424,7 +424,7 @@ "block_id": "p2:4", "page": 2, "raw_label": "text", - "role": "frontmatter_support", + "role": "affiliation", "zone": "body_zone", "bbox": [ 174.0, @@ -444,7 +444,7 @@ "block_id": "p2:5", "page": 2, "raw_label": "text", - "role": "frontmatter_support", + "role": "affiliation", "zone": "body_zone", "bbox": [ 175.0, @@ -464,7 +464,7 @@ "block_id": "p2:6", "page": 2, "raw_label": "abstract", - "role": "abstract_body", + "role": "frontmatter_support", "zone": "frontmatter_side_zone", "bbox": [ 174.0, @@ -504,7 +504,7 @@ "block_id": "p2:8", "page": 2, "raw_label": "text", - "role": "non_body_insert", + "role": "frontmatter_support", "zone": "body_zone", "bbox": [ 176.0, @@ -830,7 +830,7 @@ 175.0, 1404.0, 446.0, - 1477.0 + 1430.0 ], "review_status": "pending", "truth_role": null, @@ -843,8 +843,8 @@ { "block_id": "p5:5", "page": 5, - "raw_label": "footer", - "role": "noise", + "raw_label": "paragraph_title", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 176.0, @@ -1584,7 +1584,7 @@ "block_id": "p8:9", "page": 8, "raw_label": "text", - "role": "body_paragraph", + "role": "reference_item", "zone": "body_zone", "bbox": [ 174.0, @@ -1609,8 +1609,8 @@ "bbox": [ 175.0, 701.0, - 657.0, - 777.0 + 442.0, + 729.0 ], "review_status": "pending", "truth_role": null, @@ -1623,8 +1623,8 @@ { "block_id": "p8:11", "page": 8, - "raw_label": "footer", - "role": "noise", + "raw_label": "paragraph_title", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 175.0, @@ -2044,7 +2044,7 @@ "block_id": "p11:3", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 230.0, @@ -2064,7 +2064,7 @@ "block_id": "p11:4", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 599.0, @@ -2104,7 +2104,7 @@ "block_id": "p11:6", "page": 11, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 400.0, @@ -2824,7 +2824,7 @@ "block_id": "p16:2", "page": 16, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 408.0, @@ -3384,7 +3384,7 @@ "block_id": "p18:8", "page": 18, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "bbox": [ 176.0, @@ -3404,7 +3404,7 @@ "block_id": "p18:9", "page": 18, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 173.0, @@ -3424,7 +3424,7 @@ "block_id": "p18:10", "page": 18, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 175.0, diff --git a/audit/A6IC2SIK/block_trace.csv b/audit/A6IC2SIK/block_trace.csv index 80064bd7..f2f5b374 100644 --- a/audit/A6IC2SIK/block_trace.csv +++ b/audit/A6IC2SIK/block_trace.csv @@ -1,6 +1,6 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default 1,0,doc_title,Journal Pre-proofs,"[81.0, 138.0, 310.0, 173.0]",non_body_insert,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,short_fragment,False,False -1,1,text,Preparation and Properties of Self-Healable and Conductive PVA-Agar Hydrogel with Ultra-high Mechanical Strength,"[79.0, 229.0, 756.0, 290.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Preparation and Properties of Self-Healable and Conductive P""]",authors,0.8,frontmatter_main_zone,support_like,none,False,True +1,1,text,Preparation and Properties of Self-Healable and Conductive PVA-Agar Hydrogel with Ultra-high Mechanical Strength,"[79.0, 229.0, 756.0, 290.0]",authors,0.8,"[""page-1 zone author_zone: Preparation and Properties of Self-Healable and Conductive P""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,2,text,"Xin Xin Sun, Chun Hui Luo, Fa Liang Luo","[80.0, 318.0, 469.0, 346.0]",authors,0.8,"[""page-1 zone author_zone: Xin Xin Sun, Chun Hui Luo, Fa Liang Luo""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,3,text,PII: S0014-3057(19)32141-X,"[80.0, 374.0, 521.0, 401.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False 1,4,text,DOI: $ \underline{\text{https://doi.org/10.1016/j.eurpolymj.2019.109465}} $,"[81.0, 405.0, 728.0, 432.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: DOI: $ \\underline{\\text{https://doi.org/10.1016/j.eurpolymj""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False @@ -14,15 +14,15 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,12,text,"This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive v","[78.0, 853.0, 1094.0, 1000.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,13,footnote,© 2019 Published by Elsevier Ltd.,"[80.0, 1079.0, 393.0, 1107.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2019 Published by Elsevier Ltd.""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False 2,0,header,Journal Pre-proofs,"[493.0, 97.0, 699.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False -2,1,doc_title,Preparation and Properties of Self-Healable and Conductive PVA-Agar Hydrogel with Ultra-high Mechanical Strength,"[205.0, 160.0, 985.0, 257.0]",paper_title,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,body_zone,body_like,none,True,True -2,2,text,"Xin Xin Sun $ ^{1} $, Chun Hui Luo $ ^{1,2,3*} $ and Fa Liang Luo $ ^{4,*} $","[327.0, 271.0, 861.0, 299.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +2,1,doc_title,Preparation and Properties of Self-Healable and Conductive PVA-Agar Hydrogel with Ultra-high Mechanical Strength,"[205.0, 160.0, 985.0, 257.0]",paper_title,0.8,"[""page-1 zone title_zone: Preparation and Properties of Self-Healable and Conductive P""]",paper_title,0.8,body_zone,body_like,none,True,True +2,2,text,"Xin Xin Sun $ ^{1} $, Chun Hui Luo $ ^{1,2,3*} $ and Fa Liang Luo $ ^{4,*} $","[327.0, 271.0, 861.0, 299.0]",authors,0.8,"[""page-1 zone author_zone: Xin Xin Sun $ ^{1} $, Chun Hui Luo $ ^{1,2,3*} $ and Fa Lian""]",authors,0.8,body_zone,body_like,none,True,True 2,3,text,"1College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, Ningxia 750021, China. -*Corresponding Author. Email: luochunhui@iccas.ac.cn.","[174.0, 305.0, 983.0, 360.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False -2,4,text,"2Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, Ningxia, China.","[174.0, 367.0, 963.0, 424.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,5,text,"3Ningxia Key Laboratory of Solar Chemical Conversion Technology, North Minzu University, Yinchuan 750021, China","[175.0, 429.0, 1003.0, 484.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,6,abstract,"4State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Ningxia University, Yinchuan 750021, China. *Corresponding Author. Email: flluo@iccas.ac.cn.","[174.0, 491.0, 1013.0, 550.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_side_zone,support_like,none,True,True +*Corresponding Author. Email: luochunhui@iccas.ac.cn.","[174.0, 305.0, 983.0, 360.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: 1College of Chemistry and Chemical Engineering, North Minzu ""]",affiliation,0.8,frontmatter_side_zone,support_like,none,True,True +2,4,text,"2Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, Ningxia, China.","[174.0, 367.0, 963.0, 424.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2Key Laboratory of Chemical Engineering and Technology, Stat""]",affiliation,0.8,body_zone,body_like,none,True,True +2,5,text,"3Ningxia Key Laboratory of Solar Chemical Conversion Technology, North Minzu University, Yinchuan 750021, China","[175.0, 429.0, 1003.0, 484.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: 3Ningxia Key Laboratory of Solar Chemical Conversion Technol""]",affiliation,0.8,body_zone,body_like,none,True,True +2,6,abstract,"4State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Ningxia University, Yinchuan 750021, China. *Corresponding Author. Email: flluo@iccas.ac.cn.","[174.0, 491.0, 1013.0, 550.0]",frontmatter_support,0.78,"[""first-surviving-page support text: 4State Key Laboratory of High-efficiency Utilization of Coal""]",frontmatter_support,0.78,frontmatter_side_zone,support_like,none,True,True 2,7,abstract,"Abstract: Developing hydrogels with excellent mechanical properties and functions is important and challenging. Herein, commercial available materials, polyvinyl alcohol (PVA) and agar, are used to sy","[173.0, 557.0, 1017.0, 1387.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True -2,8,text,Key words: PVA; Agar; high strength; self-healable; electrical conductivity,"[176.0, 1402.0, 918.0, 1433.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +2,8,text,Key words: PVA; Agar; high strength; self-healable; electrical conductivity,"[176.0, 1402.0, 918.0, 1433.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,9,number,1,"[589.0, 1545.0, 601.0, 1563.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,0,header,Journal Pre-proofs,"[492.0, 97.0, 699.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False 3,1,paragraph_title,1. Introduction,"[177.0, 156.0, 339.0, 183.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True @@ -38,8 +38,8 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 5,1,text,"and physical interactions [42], instead of chemical cross-linking, to obtain a tough, functional and self-healable hydrogel with excellent mechanical properties. Agar is a biological polysaccharide wi","[173.0, 156.0, 1019.0, 796.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,2,image,,"[159.0, 817.0, 1009.0, 1281.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 5,3,figure_title,Fig.1 Schematic diagram of the synthesis of PVA-Agar-AS hydrogel.,"[297.0, 1311.0, 888.0, 1337.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.1 Schematic diagram of the synthesis of PVA-Agar-AS hydr""]",figure_caption,0.85,body_zone,legend_like,none,False,False -5,4,paragraph_title,2. Materials and Methods 2.1. Materials,"[175.0, 1404.0, 446.0, 1477.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods 2.1. Materials""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True -5,5,footer,,"[176.0, 1451.0, 317.0, 1477.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +5,4,paragraph_title,2. Materials and Methods,"[175.0, 1404.0, 446.0, 1430.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,5,paragraph_title,2.1. Materials,"[176.0, 1451.0, 317.0, 1477.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Materials""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True 5,6,text,"Poly(vinyl alcohol) (PVA, Mn=74800 g/mol) and ammonium sulfate (AS, AR) were","[175.0, 1498.0, 1014.0, 1526.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,7,number,4,"[589.0, 1546.0, 602.0, 1562.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,0,header,Journal Pre-proofs,"[492.0, 97.0, 699.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False @@ -76,9 +76,9 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 8,6,text,"The hydrogel was connected into an electrical circuit, and the resistances of the hydrogel at different temperatures was recorded and the resistivity ( $ \rho $) was calculated from the formula (8) [5","[174.0, 451.0, 1016.0, 575.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,7,display_formula, $$ \rho=R/R_{0} $$ ,"[513.0, 594.0, 612.0, 630.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True 8,8,formula_number,(8),"[981.0, 601.0, 1011.0, 628.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True -8,9,text,Where R is the resistances at different temperatures; $ R_{0} $ is the resistance at RT.,"[174.0, 654.0, 938.0, 683.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,citation_line,True,True -8,10,paragraph_title,3. Results and Discussion 3.1. Synthesis and Characterization of Hydrogels,"[175.0, 701.0, 657.0, 777.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and Discussion 3.1. Synthesis and Characterizatio""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True -8,11,footer,,"[175.0, 748.0, 657.0, 777.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +8,9,text,Where R is the resistances at different temperatures; $ R_{0} $ is the resistance at RT.,"[174.0, 654.0, 938.0, 683.0]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,citation_line,True,True +8,10,paragraph_title,3. Results and Discussion,"[175.0, 701.0, 442.0, 729.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,11,paragraph_title,3.1. Synthesis and Characterization of Hydrogels,"[175.0, 748.0, 657.0, 777.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Synthesis and Characterization of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True 8,12,text,"Agar was utilized to form hydrogen bonds with PVA followed by a simple soaking method to enhance these interactions (Fig.1). Firstly, the PVA chains underwent orderly folding, forming crystalline knot","[173.0, 796.0, 1017.0, 1295.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,13,text,"The chemical structures of s-PVA, s-Agar and PVA-Agar-15 precursor hydrogels were characterized by FT-IR. As shown in Fig.2, PVA displays the characteristic peaks at 3370, 1426 and 1096 cm⁻¹ for O-H, ","[173.0, 1310.0, 1017.0, 1528.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,14,number,7,"[589.0, 1545.0, 602.0, 1563.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -99,10 +99,10 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 11,0,header,Journal Pre-proofs,"[492.0, 97.0, 699.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False 11,1,text,"reported PVA gels to date [39, 41].","[175.0, 155.0, 519.0, 184.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,2,figure_title,(A),"[228.0, 200.0, 254.0, 220.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True -11,3,chart,,"[230.0, 202.0, 587.0, 495.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -11,4,chart,,"[599.0, 202.0, 964.0, 494.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,3,chart,,"[230.0, 202.0, 587.0, 495.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,4,chart,,"[599.0, 202.0, 964.0, 494.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 11,5,figure_title,Fig.4 Hydrogels with high mechanical properties: Tensile (A) and compressive (B) Stress and strain curves before (PVA-Agar-15) and after (PVA-Agar-15-AS) soaking in AS solution; The inset images show ,"[174.0, 507.0, 1016.0, 629.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.4 Hydrogels with high mechanical properties: Tensile (A)""]",figure_caption,0.85,body_zone,legend_like,none,False,False -11,6,figure_title,Table 1. Mechanical properties of hydrogels.,"[400.0, 663.0, 789.0, 689.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 1. Mechanical properties of hydrogels.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,6,figure_title,Table 1. Mechanical properties of hydrogels.,"[400.0, 663.0, 789.0, 689.0]",table_caption,0.9,"[""table prefix matched: Table 1. Mechanical properties of hydrogels.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 11,7,table,"
SampleTensileCompressive
Strain (%)Stress (MPa)Young's modulus (MPa)Toughness (MJ/m $ ^{3} $)<","[169.0, 691.0, 1010.0, 1227.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 11,8,vision_footnote, $ ^{*} $ the gel broken at 30% strain,"[202.0, 1242.0, 423.0, 1268.0]",footnote,0.7,"[""vision_footnote label: $ ^{*} $ the gel broken at 30% strain""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True 11,9,text,"The crosslinking density and network homogeneity of physical gels are closely related to the concentration and time of soaking [35-36]. In order to assure uniform network, the effect of soaking time o","[173.0, 1288.0, 1016.0, 1508.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -138,7 +138,7 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 15,8,number,14,"[584.0, 1544.0, 608.0, 1563.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 16,0,header,Journal Pre-proofs,"[491.0, 97.0, 699.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False 16,1,text,"respectively. Generally, the rise in $ \rho_c $ and reduce in $ \overline{M}_c/\xi $ indicate the increase in cross-linking density [68, 74], while higher $ v_{\text{exp}} $ suggests fewer imperfec","[173.0, 155.0, 1014.0, 281.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -16,2,figure_title,Table 2. Network parameters of hydrogels.,"[408.0, 296.0, 780.0, 323.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 2. Network parameters of hydrogels.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +16,2,figure_title,Table 2. Network parameters of hydrogels.,"[408.0, 296.0, 780.0, 323.0]",table_caption,0.9,"[""table prefix matched: Table 2. Network parameters of hydrogels.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 16,3,table,
Sample$ \overline{M}_{c} $(Da)$ \rho_{c} $(mmol/cm $ ^{3} $)$ \xi $ ( $ \mathring{A} $)$ F_{g} $(%)$ v_{exp} $(mol/L)
s-PVA,"[176.0, 327.0, 1011.0, 743.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 16,4,vision_footnote,The network parameters of hydrogels were calculated according Eq. S1&S7 (Supplementary Material),"[178.0, 753.0, 923.0, 778.0]",footnote,0.7,"[""vision_footnote label: The network parameters of hydrogels were calculated accordin""]",footnote,0.7,body_zone,body_like,none,True,True 16,5,text,"The network structures of gels were further examined by SEM. As shown in Fig.8, the two hydrogels all show a typical honeycomb pore structure [75]. However, the PVA-Agar-15 precursor hydrogel has an u","[173.0, 822.0, 1017.0, 1134.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -148,7 +148,7 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 16,9,image,,"[598.0, 1139.0, 965.0, 1388.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 16,10,figure_title,Fig.8. SEM images of (A) PVA-Agar-15 and (B) PVA-Agar-15-AS hydrogels.,"[258.0, 1400.0, 929.0, 1426.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.8. SEM images of (A) PVA-Agar-15 and (B) PVA-Agar-15-AS ""]",figure_caption,0.85,body_zone,legend_like,none,False,False 16,11,paragraph_title,3.5. Self-healing property of hydrogel,"[174.0, 1446.0, 549.0, 1475.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Self-healing property of hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True -16,12,text,"Due to the dynamic nature of junctions, the hydrogel was expected to display self-","[174.0, 1493.0, 1014.0, 1522.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,12,text,"Due to the dynamic nature of junctions, the hydrogel was expected to display self-","[174.0, 1493.0, 1014.0, 1522.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 16,13,number,15,"[585.0, 1544.0, 607.0, 1563.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 17,0,header,Journal Pre-proofs,"[492.0, 97.0, 699.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False 17,1,text,"healing properties [55, 76]. The sample was cut by a razor and pressed together in a sealed tube, then the self-healing behavior of PVA-Agar-15-AS gel was investigated. As presented in Fig. 9, the hea","[172.0, 155.0, 1018.0, 701.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -166,9 +166,9 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 18,5,figure_title,Fig.10 The conductivity photos of (A) PVA-Agar-15 hydrogel and (B) PVA-Agar-15-AS hydrogel; (C) The resistance ratio (R/R₀) of the PVA-Agar-15-AS hydrogel as a function of temperature; (D) The resista,"[173.0, 584.0, 1015.0, 706.0]",figure_caption_candidate,0.85,"[""figure_title label: Fig.10 The conductivity photos of (A) PVA-Agar-15 hydrogel a""]",figure_caption,0.85,body_zone,legend_like,none,False,False 18,6,paragraph_title,4. Conclusion,"[175.0, 718.0, 323.0, 744.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Conclusion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True 18,7,text,"In this work, we demonstrate a universal method based on commercially available sources and simple physical interactions, instead of chemical cross-linking, to obtain a tough, functional and self-heal","[173.0, 763.0, 1017.0, 1123.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -18,8,paragraph_title,Acknowledgements,"[176.0, 1131.0, 384.0, 1159.0]",backmatter_heading,0.8,"[""backmatter heading on page 18: Acknowledgements""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -18,9,text,"The authors appreciate financial support from the National Natural Science Foundation of China (21464001), Innovation Program Fund for Graduate Students of North Minzu University (YCX19116), the East-","[173.0, 1169.0, 1016.0, 1481.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -18,10,text,The authors declare no competing financial interest.,"[175.0, 1496.0, 682.0, 1526.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,8,paragraph_title,Acknowledgements,"[176.0, 1131.0, 384.0, 1159.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +18,9,text,"The authors appreciate financial support from the National Natural Science Foundation of China (21464001), Innovation Program Fund for Graduate Students of North Minzu University (YCX19116), the East-","[173.0, 1169.0, 1016.0, 1481.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,10,text,The authors declare no competing financial interest.,"[175.0, 1496.0, 682.0, 1526.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 18,11,number,17,"[585.0, 1545.0, 607.0, 1563.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 19,0,header,Journal Pre-proofs,"[491.0, 97.0, 700.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False 19,1,paragraph_title,Reference,"[176.0, 148.0, 287.0, 173.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Reference""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True diff --git a/audit/A6IC2SIK/figure_table_ownership_summary.json b/audit/A6IC2SIK/figure_table_ownership_summary.json index 4562f935..fb04d33f 100644 --- a/audit/A6IC2SIK/figure_table_ownership_summary.json +++ b/audit/A6IC2SIK/figure_table_ownership_summary.json @@ -1,9 +1,9 @@ { "figures": { - 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"role": "frontmatter_support", + "role": "affiliation", "zone": "body_zone", "render_default": true, "snippet": "2Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Com", @@ -86,19 +96,29 @@ { "block_id": "p2:5", "page": 2, - "role": "frontmatter_support", + "role": "affiliation", "zone": "body_zone", "render_default": true, "snippet": "3Ningxia Key Laboratory of Solar Chemical Conversion Technology, North Minzu Uni", "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p2:6", + "page": 2, + "role": "frontmatter_support", + "zone": "frontmatter_side_zone", + "render_default": true, + "snippet": "4State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p2:8", "page": 2, - "role": "non_body_insert", + "role": "frontmatter_support", "zone": "body_zone", - "render_default": false, + "render_default": true, "snippet": "Key words: PVA; Agar; high strength; self-healable; electrical conductivity", "found_in_fulltext": false, "fulltext_offset": -1 @@ -131,7 +151,7 @@ "render_default": true, "snippet": "1. Introduction", "found_in_fulltext": true, - "fulltext_offset": 2614 + "fulltext_offset": 2428 }, { "block_id": "p3:2", @@ -140,8 +160,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Human tissues including muscle, skins, cartilage and tendon possess well-defined", - "found_in_fulltext": true, - "fulltext_offset": 2630 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:3", @@ -150,8 +170,8 @@ "zone": "body_zone", "render_default": true, "snippet": "To achieve this goal, a variety of biocompatible polymers including poly(hydroxy", - "found_in_fulltext": true, - "fulltext_offset": 3734 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:4", @@ -161,7 +181,7 @@ "render_default": true, "snippet": "Among these biocompatible materials, PVA gels prepared by freezing-thawing (FT)", "found_in_fulltext": true, - "fulltext_offset": 4932 + "fulltext_offset": 2444 }, { "block_id": "p3:5", @@ -191,7 +211,7 @@ "render_default": true, "snippet": "have attracted much attention for their easy operation and non-toxicity [15-16, ", "found_in_fulltext": true, - "fulltext_offset": 5028 + "fulltext_offset": 2540 }, { "block_id": "p4:2", @@ -200,8 +220,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Various approaches have been developed to toughen hydrogels including dual-netwo", - "found_in_fulltext": true, - "fulltext_offset": 5832 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:3", @@ -211,7 +231,7 @@ "render_default": false, "snippet": "3", "found_in_fulltext": true, - "fulltext_offset": 1049 + "fulltext_offset": 863 }, { "block_id": "p5:0", @@ -231,7 +251,7 @@ "render_default": true, "snippet": "and physical interactions [42], instead of chemical cross-linking, to obtain a t", "found_in_fulltext": true, - "fulltext_offset": 7532 + "fulltext_offset": 3360 }, { "block_id": "p5:3", @@ -249,9 +269,19 @@ "role": "section_heading", "zone": "body_zone", "render_default": true, - "snippet": "2. Materials and Methods 2.1. Materials", + "snippet": "2. Materials and Methods", "found_in_fulltext": true, - "fulltext_offset": 8739 + "fulltext_offset": 4570 + }, + { + "block_id": "p5:5", + "page": 5, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "2.1. Materials", + "found_in_fulltext": true, + "fulltext_offset": 4599 }, { "block_id": "p5:6", @@ -260,8 +290,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Poly(vinyl alcohol) (PVA, Mn=74800 g/mol) and ammonium sulfate (AS, AR) were", - "found_in_fulltext": true, - "fulltext_offset": 8779 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p5:7", @@ -291,7 +321,7 @@ "render_default": true, "snippet": "purchased from Aladdin Reagent (Shanghai) Co., Ltd. Agar was obtained from Beiji", "found_in_fulltext": true, - "fulltext_offset": 8914 + "fulltext_offset": 4672 }, { "block_id": "p6:2", @@ -300,8 +330,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.2. Preparation of PVA-Agar-AS hydrogel", - "found_in_fulltext": true, - "fulltext_offset": 9078 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p6:3", @@ -310,8 +340,8 @@ "zone": "body_zone", "render_default": true, "snippet": "PVA-Agar-AS hydrogels were synthesized by a combination of FT and soaking method", - "found_in_fulltext": true, - "fulltext_offset": 9119 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p6:4", @@ -321,7 +351,7 @@ "render_default": true, "snippet": "2.3. 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Calculation of component content", "found_in_fulltext": true, - "fulltext_offset": 12418 + "fulltext_offset": 5642 }, { "block_id": "p7:5", @@ -441,7 +471,7 @@ "render_default": true, "snippet": "A gravimetric method was used to measure the content of each component. The wate", "found_in_fulltext": true, - "fulltext_offset": 12456 + "fulltext_offset": 5680 }, { "block_id": "p7:6", @@ -461,7 +491,7 @@ "render_default": false, "snippet": "(2)", "found_in_fulltext": true, - "fulltext_offset": 12653 + "fulltext_offset": 5877 }, { "block_id": "p7:8", @@ -501,7 +531,7 @@ "render_default": false, "snippet": "(4)", "found_in_fulltext": true, - "fulltext_offset": 12657 + "fulltext_offset": 5881 }, { "block_id": "p7:12", @@ -541,7 +571,7 @@ "render_default": true, "snippet": "2.6. Self-healing property", "found_in_fulltext": true, - "fulltext_offset": 12912 + "fulltext_offset": 6136 }, { "block_id": "p8:2", @@ -550,8 +580,8 @@ "zone": "body_zone", "render_default": true, "snippet": "The resultant hydrogel was cut into two parts and pressed together in a sealed t", - "found_in_fulltext": true, - "fulltext_offset": 12939 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:3", @@ -581,7 +611,7 @@ "render_default": true, "snippet": "2.7. Conductivity", "found_in_fulltext": true, - "fulltext_offset": 13194 + "fulltext_offset": 6167 }, { "block_id": "p8:6", @@ -590,8 +620,8 @@ "zone": "body_zone", "render_default": true, "snippet": "The hydrogel was connected into an electrical circuit, and the resistances of th", - "found_in_fulltext": true, - "fulltext_offset": 13212 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:7", @@ -610,13 +640,13 @@ "zone": "body_zone", "render_default": false, "snippet": "(8)", - "found_in_fulltext": true, - "fulltext_offset": 13403 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:9", "page": 8, - "role": "body_paragraph", + "role": "reference_item", "zone": "body_zone", "render_default": true, "snippet": "Where R is the resistances at different temperatures; $ R_{0} $ is the resistanc", @@ -629,9 +659,19 @@ "role": "section_heading", "zone": "body_zone", "render_default": true, - "snippet": "3. Results and Discussion 3.1. Synthesis and Characterization of Hydrogels", + "snippet": "3. Results and Discussion", "found_in_fulltext": true, - "fulltext_offset": 13499 + "fulltext_offset": 6274 + }, + { + "block_id": "p8:11", + "page": 8, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "3.1. Synthesis and Characterization of Hydrogels", + "found_in_fulltext": true, + "fulltext_offset": 6304 }, { "block_id": "p8:12", @@ -641,7 +681,7 @@ "render_default": true, "snippet": "Agar was utilized to form hydrogen bonds with PVA followed by a simple soaking m", "found_in_fulltext": true, - "fulltext_offset": 13574 + "fulltext_offset": 6353 }, { "block_id": "p8:13", @@ -651,7 +691,7 @@ "render_default": true, "snippet": "The chemical structures of s-PVA, s-Agar and PVA-Agar-15 precursor hydrogels wer", "found_in_fulltext": true, - "fulltext_offset": 14441 + "fulltext_offset": 7220 }, { "block_id": "p8:14", @@ -661,7 +701,7 @@ "render_default": false, "snippet": "7", "found_in_fulltext": true, - "fulltext_offset": 422 + "fulltext_offset": 2961 }, { "block_id": "p9:0", @@ -701,7 +741,7 @@ "render_default": true, "snippet": "3.2. 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Mechanical properties of hydrogels.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p11:8", "page": 11, @@ -821,7 +871,7 @@ "render_default": true, "snippet": "The crosslinking density and network homogeneity of physical gels are closely re", "found_in_fulltext": true, - "fulltext_offset": 18551 + "fulltext_offset": 11330 }, { "block_id": "p11:10", @@ -851,7 +901,7 @@ "render_default": true, "snippet": "saturated AS aqueous solution (~40 wt%) was used to shorten the soaking time. As", "found_in_fulltext": true, - "fulltext_offset": 19025 + "fulltext_offset": 11846 }, { "block_id": "p12:4", @@ -871,7 +921,7 @@ "render_default": true, "snippet": "3.3. The energy dissipation mechanism of hydrogel", "found_in_fulltext": true, - "fulltext_offset": 19637 + "fulltext_offset": 12458 }, { "block_id": "p12:6", @@ -880,8 +930,8 @@ "zone": "body_zone", "render_default": true, "snippet": "We have demonstrated that the mechanical properties increased significantly afte", - "found_in_fulltext": true, - "fulltext_offset": 19687 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p12:7", @@ -891,7 +941,7 @@ "render_default": false, "snippet": "11", "found_in_fulltext": true, - "fulltext_offset": 4150 + "fulltext_offset": 10647 }, { "block_id": "p13:0", @@ -911,7 +961,7 @@ "render_default": true, "snippet": "toughness recovery at a 100% strain could reach 56.1% after relaxing at room tem", "found_in_fulltext": true, - "fulltext_offset": 20934 + "fulltext_offset": 12567 }, { "block_id": "p13:6", @@ -930,8 +980,8 @@ "zone": "body_zone", "render_default": true, "snippet": "To gain additional insights into the toughening mechanism, water contents, cross", - "found_in_fulltext": true, - "fulltext_offset": 21773 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p13:8", @@ -941,7 +991,7 @@ "render_default": false, "snippet": "12", "found_in_fulltext": true, - "fulltext_offset": 4356 + "fulltext_offset": 6728 }, { "block_id": "p14:0", @@ -961,7 +1011,7 @@ "render_default": true, "snippet": "the water content of the PVA-Agar-15 precursor hydrogel decreases from 88.5 wt% ", "found_in_fulltext": true, - "fulltext_offset": 22046 + "fulltext_offset": 13423 }, { "block_id": "p14:2", @@ -971,7 +1021,7 @@ "render_default": false, "snippet": "13", "found_in_fulltext": true, - "fulltext_offset": 20927 + "fulltext_offset": 12560 }, { "block_id": "p15:0", @@ -1011,7 +1061,7 @@ "render_default": false, "snippet": "14", "found_in_fulltext": true, - "fulltext_offset": 4359 + "fulltext_offset": 7392 }, { "block_id": "p16:0", @@ -1033,6 +1083,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p16:2", + "page": 16, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 2. Network parameters of hydrogels.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p16:4", "page": 16, @@ -1041,7 +1101,7 @@ "render_default": true, "snippet": "The network parameters of hydrogels were calculated according Eq. S1&S7 (Supplem", "found_in_fulltext": true, - "fulltext_offset": 25547 + "fulltext_offset": 15661 }, { "block_id": "p16:5", @@ -1051,7 +1111,7 @@ "render_default": true, "snippet": "The network structures of gels were further examined by SEM. As shown in Fig.8, ", "found_in_fulltext": true, - "fulltext_offset": 25644 + "fulltext_offset": 15758 }, { "block_id": "p16:10", @@ -1071,7 +1131,7 @@ "render_default": true, "snippet": "3.5. Self-healing property of hydrogel", "found_in_fulltext": true, - "fulltext_offset": 26187 + "fulltext_offset": 16301 }, { "block_id": "p16:12", @@ -1081,7 +1141,7 @@ "render_default": true, "snippet": "Due to the dynamic nature of junctions, the hydrogel was expected to display sel", "found_in_fulltext": true, - "fulltext_offset": 26226 + "fulltext_offset": 16340 }, { "block_id": "p16:13", @@ -1091,7 +1151,7 @@ "render_default": false, "snippet": "15", "found_in_fulltext": true, - "fulltext_offset": 4477 + "fulltext_offset": 2613 }, { "block_id": "p17:0", @@ -1111,7 +1171,7 @@ "render_default": true, "snippet": "healing properties [55, 76]. The sample was cut by a razor and pressed together ", "found_in_fulltext": true, - "fulltext_offset": 26400 + "fulltext_offset": 16514 }, { "block_id": "p17:4", @@ -1131,7 +1191,7 @@ "render_default": true, "snippet": "3.6. Conductivity of hydrogel", "found_in_fulltext": true, - "fulltext_offset": 27403 + "fulltext_offset": 17517 }, { "block_id": "p17:6", @@ -1180,8 +1240,8 @@ "zone": "body_zone", "render_default": true, "snippet": "4. Conclusion", - "found_in_fulltext": true, - "fulltext_offset": 28139 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p18:7", @@ -1190,38 +1250,38 @@ "zone": "body_zone", "render_default": true, "snippet": "In this work, we demonstrate a universal method based on commercially available ", - "found_in_fulltext": true, - "fulltext_offset": 28153 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p18:8", "page": 18, - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Acknowledgements", "found_in_fulltext": true, - "fulltext_offset": 28881 + "fulltext_offset": 17608 }, { "block_id": "p18:9", "page": 18, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "The authors appreciate financial support from the National Natural Science Found", "found_in_fulltext": true, - "fulltext_offset": 28900 + "fulltext_offset": 17627 }, { "block_id": "p18:10", "page": 18, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "The authors declare no competing financial interest.", "found_in_fulltext": true, - "fulltext_offset": 28826 + "fulltext_offset": 18147 }, { "block_id": "p18:11", @@ -1231,7 +1291,7 @@ "render_default": false, "snippet": "17", "found_in_fulltext": true, - "fulltext_offset": 3996 + "fulltext_offset": 8469 }, { "block_id": "p19:0", @@ -1251,7 +1311,7 @@ "render_default": true, "snippet": "Reference", "found_in_fulltext": true, - "fulltext_offset": 29484 + "fulltext_offset": 18264 }, { "block_id": "p19:2", @@ -1260,8 +1320,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[1] Z.G. Zhao, R.C. Fang, Q.F. Rong, M.J. Liu, Bioinspired Nanocomposite Hydroge", - "found_in_fulltext": true, - "fulltext_offset": 31750 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:3", @@ -1270,8 +1330,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[2] C.J. Little, N.K. Bawolin, X. Chen, Mechanical properties of natural cartila", - "found_in_fulltext": true, - "fulltext_offset": 29494 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:4", @@ -1281,7 +1341,7 @@ "render_default": true, "snippet": "[3] M. Ribeiro, M.A. de Moraes, M.M. Beppu, M.P. Garcia, M.H. Fernandes, F.J. Mo", "found_in_fulltext": true, - "fulltext_offset": 29642 + "fulltext_offset": 18274 }, { "block_id": "p19:5", @@ -1291,7 +1351,7 @@ "render_default": true, "snippet": "[4] C.J. Fan, D.A Wang, A biodegradable PEG-based micro-cavitary hydrogel as sca", "found_in_fulltext": true, - "fulltext_offset": 29871 + "fulltext_offset": 18503 }, { "block_id": "p19:6", @@ -1300,8 +1360,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[5] F. Yu, X.D. Cao, Y.L. Li, L. Zeng, J.H. Zhu, G. Wang, X.F. Chen, Diels–Alder", - "found_in_fulltext": true, - "fulltext_offset": 31896 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:7", @@ -1310,8 +1370,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[6] D.A. Gyles, L.D. Castro, J.O.C. Silva, R.M. Ribeiro-Costa, A review of the d", - "found_in_fulltext": true, - "fulltext_offset": 32145 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:8", @@ -1321,7 +1381,7 @@ "render_default": true, "snippet": "[7] J.F. Pan, L. Yuan, C.A. Guo, X.H. Geng, T. Fei, W.S. Fan, S. Li, H.F. Yuan; ", "found_in_fulltext": true, - "fulltext_offset": 32348 + "fulltext_offset": 20382 }, { "block_id": "p19:9", @@ -1331,7 +1391,7 @@ "render_default": true, "snippet": "[8] G.J. Graulus, A. Mignon, S. Van Vlierberghe, H. Declercq, K. Fehér, M. Corne", "found_in_fulltext": true, - "fulltext_offset": 30025 + "fulltext_offset": 18657 }, { "block_id": "p19:10", @@ -1341,7 +1401,7 @@ "render_default": true, "snippet": "[9] C.C. Lin, K.S. Anseth, PEG hydrogels for the controlled release of biomolecu", "found_in_fulltext": true, - "fulltext_offset": 30259 + "fulltext_offset": 18891 }, { "block_id": "p19:11", @@ -1351,7 +1411,7 @@ "render_default": true, "snippet": "[10] M. Teodorescu, M. Bercea, Poly(vinylpyrrolidone) – A Versatile Polymer for ", "found_in_fulltext": true, - "fulltext_offset": 30399 + "fulltext_offset": 19031 }, { "block_id": "p19:12", @@ -1361,7 +1421,7 @@ "render_default": true, "snippet": "[11] P.D. Dalton, L. Flynn, M.S. Shoichet. Manufacture of poly(2-hydroxyethyl me", "found_in_fulltext": true, - "fulltext_offset": 30570 + "fulltext_offset": 19202 }, { "block_id": "p19:13", @@ -1371,7 +1431,7 @@ "render_default": true, "snippet": "[12] T.R. Dargaville, J. R. Park, R. Hoogenboom, Poly(2-oxazoline) Hydrogels: St", "found_in_fulltext": true, - "fulltext_offset": 30770 + "fulltext_offset": 19402 }, { "block_id": "p19:14", @@ -1381,7 +1441,7 @@ "render_default": true, "snippet": "[13] F.A. Jerca, A.M. Anghelache, E. Ghibu, S. Cecoltan; I. C. Stancu, R. Trusca", "found_in_fulltext": true, - "fulltext_offset": 30929 + "fulltext_offset": 19561 }, { "block_id": "p19:15", @@ -1391,7 +1451,7 @@ "render_default": true, "snippet": "[14] F.A. Jerca, V.V. Jerca, A.M. Anghelache, D.M. Vuluga, R. Hoogenboom, Poly(2", "found_in_fulltext": true, - "fulltext_offset": 31182 + "fulltext_offset": 19814 }, { "block_id": "p19:16", @@ -1401,7 +1461,7 @@ "render_default": true, "snippet": "[15] R. Ricciardi, F. Auriemma, C. De Rosa, Structure and Properties of Poly(vin", "found_in_fulltext": true, - "fulltext_offset": 31382 + "fulltext_offset": 20014 }, { "block_id": "p19:17", @@ -1411,7 +1471,7 @@ "render_default": true, "snippet": "[16] C.M. Hassan, N.A. Peppas, Structure and Applications of Poly(vinyl alcohol)", "found_in_fulltext": true, - "fulltext_offset": 31554 + "fulltext_offset": 20186 }, { "block_id": "p19:18", @@ -1421,7 +1481,7 @@ "render_default": true, "snippet": "[17] X.W. Xu, F.A. Jerca, V.V. Jerca, R. Hoogenboom, Covalent Poly(2-Isopropenyl", "found_in_fulltext": true, - "fulltext_offset": 32600 + "fulltext_offset": 20634 }, { "block_id": "p19:19", @@ -1431,7 +1491,7 @@ "render_default": false, "snippet": "18", "found_in_fulltext": true, - "fulltext_offset": 1406 + "fulltext_offset": 1220 }, { "block_id": "p20:0", @@ -1451,7 +1511,7 @@ "render_default": true, "snippet": "Toughness through Secondary Terpyridine Metal-Coordination Crosslinks, Adv. Func", "found_in_fulltext": true, - "fulltext_offset": 34464 + "fulltext_offset": 21935 }, { "block_id": "p20:2", @@ -1460,8 +1520,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[18] M. Kobayashi, J. Toguchida, M. Oka, Preliminary study of polyvinyl alcohol-", - "found_in_fulltext": true, - "fulltext_offset": 32760 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p20:3", @@ -1470,8 +1530,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[19] R. Ricciardi, C. Gaillet, G. Ducouret, F. Lafuma, F. Lauprêtre, Investigati", - "found_in_fulltext": true, - "fulltext_offset": 34570 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p20:4", @@ -1481,7 +1541,7 @@ "render_default": true, "snippet": "[20] R. Ricciardi, F. Auriemma, C. De Rosa, F. Lauprêtre, X-ray Diffraction Anal", "found_in_fulltext": true, - "fulltext_offset": 34803 + "fulltext_offset": 22041 }, { "block_id": "p20:5", @@ -1491,7 +1551,7 @@ "render_default": true, "snippet": "[21] R. Ricciardi, F. Auriemma, C. Gaillet, C. De Rosa, F. Lauprêtre, Investigat", "found_in_fulltext": true, - "fulltext_offset": 32910 + "fulltext_offset": 20794 }, { "block_id": "p20:6", @@ -1500,8 +1560,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[22] R. Ricciardi, G. D'Errico, F. Auriemma, G. Ducouret, A.M. Tedeschi, C. De R", - "found_in_fulltext": true, - "fulltext_offset": 33121 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p20:7", @@ -1510,8 +1570,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[23] C.M. Hassan, N.A. Peppas, Structure and Morphology of Freeze/Thawed PVA Hyd", - "found_in_fulltext": true, - "fulltext_offset": 33410 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p20:8", @@ -1521,7 +1581,7 @@ "render_default": true, "snippet": "[24] S.R. Stauffer, N.A. Peppast, Poly(vinyl alcohol) hydrogels prepared by free", "found_in_fulltext": true, - "fulltext_offset": 35003 + "fulltext_offset": 22241 }, { "block_id": "p20:9", @@ -1531,7 +1591,7 @@ "render_default": true, "snippet": "[25] N.A. Peppas, Turbidimetric studies of aqueous poly(vinyl alcohol) solutions", "found_in_fulltext": true, - "fulltext_offset": 33534 + "fulltext_offset": 21005 }, { "block_id": "p20:10", @@ -1541,7 +1601,7 @@ "render_default": true, "snippet": "[26] Y. Liu, N.E. Vrana, P.A. Cahill, G.B. McGuinness, Physically crosslinked co", "found_in_fulltext": true, - "fulltext_offset": 35144 + "fulltext_offset": 22382 }, { "block_id": "p20:11", @@ -1551,7 +1611,7 @@ "render_default": true, "snippet": "[27] P.J. Willcox, D.W. Howie, K. Schmidt-Rohr, D.A. Hoagland, S.P. Gido, S. Pud", "found_in_fulltext": true, - "fulltext_offset": 35398 + "fulltext_offset": 22636 }, { "block_id": "p20:12", @@ -1561,7 +1621,7 @@ "render_default": true, "snippet": "[28] L.E. Millon, H. Mohammadi, W.K. Wan, Anisotropic polyvinyl alcohol hydrogel", "found_in_fulltext": true, - "fulltext_offset": 35656 + "fulltext_offset": 22894 }, { "block_id": "p20:13", @@ -1571,7 +1631,7 @@ "render_default": true, "snippet": "[29] L. Zhang, J. Zhao, J.T. Zhu, C.C. He, H.L. Wang, Anisotropic tough poly(vin", "found_in_fulltext": true, - "fulltext_offset": 33660 + "fulltext_offset": 21131 }, { "block_id": "p20:14", @@ -1581,7 +1641,7 @@ "render_default": true, "snippet": "[30] M.I. Baker, S.P. Walsh, Z. Schwartz, B.D. Boyan, A review of polyvinyl alco", "found_in_fulltext": true, - "fulltext_offset": 33791 + "fulltext_offset": 21262 }, { "block_id": "p20:15", @@ -1591,7 +1651,7 @@ "render_default": true, "snippet": "[31] J.P. Gong, Y. Katsuyama, T. Kurokawa, Y. Osada, Double-Network Hydrogels wi", "found_in_fulltext": true, - "fulltext_offset": 33983 + "fulltext_offset": 21454 }, { "block_id": "p20:16", @@ -1601,7 +1661,7 @@ "render_default": true, "snippet": "[32] K. Haraguchi, Nanocomposite Hydrogels: A Unique Organic-Inorganic Network S", "found_in_fulltext": true, - "fulltext_offset": 34135 + "fulltext_offset": 21606 }, { "block_id": "p20:17", @@ -1611,7 +1671,7 @@ "render_default": true, "snippet": "[33] O. Yasushi, I. Kohzo, The Polyrotaxane Gel: A Topological Gel by Figure-of-", "found_in_fulltext": true, - "fulltext_offset": 34334 + "fulltext_offset": 21805 }, { "block_id": "p20:18", @@ -1621,7 +1681,7 @@ "render_default": true, "snippet": "[34] T. Huang, H.G. Xu, K.X. Jiao, L.P. Zhu, H.R. 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Mater. 28 (2016) ", "found_in_fulltext": true, - "fulltext_offset": 39231 + "fulltext_offset": 25619 }, { "block_id": "p22:6", @@ -1900,8 +1960,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[56] Z. Lei, P. Wu, A supramolecular biomimetic skin combining a wide spectrum o", - "found_in_fulltext": true, - "fulltext_offset": 41646 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p22:7", @@ -1910,8 +1970,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[57] Y.J. Sun, N.P. Xiang, X.C. Jiang, L.X. Hou, Preparation of high tough poly(", - "found_in_fulltext": true, - "fulltext_offset": 39322 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p22:8", @@ -1921,7 +1981,7 @@ "render_default": true, "snippet": "[58] L. Fan, H. Yang, J. Yang, M. Peng, J. Hu, Preparation and characterization ", "found_in_fulltext": true, - "fulltext_offset": 41813 + "fulltext_offset": 27658 }, { "block_id": "p22:9", @@ -1931,7 +1991,7 @@ "render_default": true, "snippet": "[59] K. Prasad. G. Mehta. R. Meena. A.K. Siddhanta Hydrogel-forming agar-graft-P", "found_in_fulltext": true, - "fulltext_offset": 39494 + "fulltext_offset": 25710 }, { "block_id": "p22:10", @@ -1941,7 +2001,7 @@ "render_default": true, "snippet": "[60] E. Pretsch, P. Buhlmann, M. Badertscher, Structure Determination of Organic", "found_in_fulltext": true, - "fulltext_offset": 39701 + "fulltext_offset": 25917 }, { "block_id": "p22:11", @@ -1951,7 +2011,7 @@ "render_default": true, "snippet": "[61] S.J. Shi, X. Peng, T.Q. Liu, Y. N. Chen, C.C. He, H.L. Wang, Facile prepara", "found_in_fulltext": true, - "fulltext_offset": 41984 + "fulltext_offset": 27829 }, { "block_id": "p22:12", @@ -1961,7 +2021,7 @@ "render_default": true, "snippet": "[62] X. Zhang, W.F. Liu, D.J. Yang, X.Q. Qiu, Biomimetic Supertough and Strong B", "found_in_fulltext": true, - "fulltext_offset": 39860 + "fulltext_offset": 26076 }, { "block_id": "p22:13", @@ -1971,7 +2031,7 @@ "render_default": true, "snippet": "[63] X. Dai, Y. Zhang, L. Gao, T. Bai, W. Wang, Y. Cui, W. Liu, A Mechanically S", "found_in_fulltext": true, - "fulltext_offset": 40083 + "fulltext_offset": 26299 }, { "block_id": "p22:14", @@ -1981,7 +2041,7 @@ "render_default": true, "snippet": "[64] P.J. Flory, Principles of polymer chemistry, US:Cornell University Press (1", "found_in_fulltext": true, - "fulltext_offset": 40282 + "fulltext_offset": 26498 }, { "block_id": "p22:15", @@ -1991,7 +2051,7 @@ "render_default": true, "snippet": "[65] X. Chen, T. Yang, S. Kataoka, P.S. Cremer, Specific Ion Effects on Interfac", "found_in_fulltext": true, - "fulltext_offset": 40376 + "fulltext_offset": 26592 }, { "block_id": "p22:16", @@ -2001,7 +2061,7 @@ "render_default": true, "snippet": "[66] L.M. Pegram, J. Record, M. Thomas, Thermodynamic Origin of Hofmeister Ion E", "found_in_fulltext": true, - "fulltext_offset": 40539 + "fulltext_offset": 26755 }, { "block_id": "p22:17", @@ -2011,7 +2071,7 @@ "render_default": true, "snippet": "[67] R.B. Bai, J.W. Yang, Z.G. Suo, Fatigue of hydrogels, J. Theor. Appl. Mech. ", "found_in_fulltext": true, - "fulltext_offset": 40666 + "fulltext_offset": 26882 }, { "block_id": "p22:18", @@ -2021,7 +2081,7 @@ "render_default": true, "snippet": "[68] A.V. Tobolsky, D.W. Carlson, N. Indictor, Rubber elasticity and chain confi", "found_in_fulltext": true, - "fulltext_offset": 40765 + "fulltext_offset": 26981 }, { "block_id": "p22:19", @@ -2031,7 +2091,7 @@ "render_default": true, "snippet": "[69] H. Itagaki, T. Kurokawa, H. Furukawa, T. Nakajima, Y. Katsumoto, J.P. Gong,", "found_in_fulltext": true, - "fulltext_offset": 40911 + "fulltext_offset": 27127 }, { "block_id": "p22:20", @@ -2041,7 +2101,7 @@ "render_default": true, "snippet": "[70] S.J. Kim, C.K. Lee, S.I. Kim, Characterization of the Water State of Hyalur", "found_in_fulltext": true, - "fulltext_offset": 42222 + "fulltext_offset": 28067 }, { "block_id": "p22:21", @@ -2051,7 +2111,7 @@ "render_default": false, "snippet": "21", "found_in_fulltext": true, - "fulltext_offset": 426 + "fulltext_offset": 9184 }, { "block_id": "p23:0", @@ -2071,7 +2131,7 @@ "render_default": true, "snippet": "Poly(vinyl alcohol) Interpenetrating Polymer Networks, J. Appl. Polym. Sci. 92 (", "found_in_fulltext": true, - "fulltext_offset": 43187 + "fulltext_offset": 28660 }, { "block_id": "p23:2", @@ -2080,8 +2140,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[71] R. Wang, Q. Wang; L. Li, Evaporation behaviour of water and its plasticizin", - "found_in_fulltext": true, - "fulltext_offset": 43284 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p23:3", @@ -2090,8 +2150,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[72] X.Y. Zhou, F. Zhao, Y.H. Guo, B. Rosenberger, G.H. Yu, Architecting highly ", - "found_in_fulltext": true, - "fulltext_offset": 42333 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p23:4", @@ -2101,7 +2161,7 @@ "render_default": true, "snippet": "[73] J. Hu, T. Kurokawa, K. Hiwatashi, T. Nakajima, Z.L. Wu, S.M. Liang, J.P. Go", "found_in_fulltext": true, - "fulltext_offset": 42524 + "fulltext_offset": 28178 }, { "block_id": "p23:5", @@ -2111,7 +2171,7 @@ "render_default": true, "snippet": "[74] G.Q. Jiang, C. Liu, X.L. Liu, Q.R. Chen, G.H. Zhang, M. Yang, F.Q. Liu Netw", "found_in_fulltext": true, - "fulltext_offset": 42756 + "fulltext_offset": 28410 }, { "block_id": "p23:6", @@ -2120,8 +2180,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "[75] H.H. Trieu, S. Qutubuddin, Polyvinyl alcohol hydrogels I. 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Lu,", "found_in_fulltext": true, - "fulltext_offset": 43616 + "fulltext_offset": 28757 }, { "block_id": "p23:9", @@ -2151,7 +2211,7 @@ "render_default": false, "snippet": "22", "found_in_fulltext": true, - "fulltext_offset": 5629 + "fulltext_offset": 3141 }, { "block_id": "p24:0", @@ -2181,7 +2241,7 @@ "render_default": true, "snippet": "Electrical conductivity and Self-healing", "found_in_fulltext": true, - "fulltext_offset": 43895 + "fulltext_offset": 29036 }, { "block_id": "p24:5", @@ -2191,7 +2251,7 @@ "render_default": false, "snippet": "23", "found_in_fulltext": true, - "fulltext_offset": 5111 + "fulltext_offset": 2623 }, { "block_id": "p25:0", @@ -2211,7 +2271,7 @@ "render_default": false, "snippet": "Highlights", "found_in_fulltext": true, - "fulltext_offset": 44011 + "fulltext_offset": 29152 }, { "block_id": "p25:2", @@ -2220,8 +2280,8 @@ "zone": "", "render_default": false, "snippet": "• A method from commercially available sources is reported to obtain functional ", - "found_in_fulltext": true, - "fulltext_offset": 44024 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:3", @@ -2230,8 +2290,8 @@ "zone": "", "render_default": false, "snippet": "• The tensile strength and toughness of the gel are 18.0 MPa and 42.3 MJ/m $ ^{3", - "found_in_fulltext": true, - "fulltext_offset": 44111 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:4", @@ -2241,7 +2301,7 @@ "render_default": false, "snippet": "• The gel is self-healable and conductive", "found_in_fulltext": true, - "fulltext_offset": 44198 + "fulltext_offset": 29175 }, { "block_id": "p25:5", @@ -2251,7 +2311,7 @@ "render_default": false, "snippet": "- This hydrogel might find applications as a biocompatible and bioactive materia", "found_in_fulltext": true, - "fulltext_offset": 44242 + "fulltext_offset": 29219 }, { "block_id": "p25:6", @@ -2261,7 +2321,7 @@ "render_default": false, "snippet": "24", "found_in_fulltext": true, - "fulltext_offset": 5174 + "fulltext_offset": 2686 }, { "block_id": "p26:0", @@ -2281,7 +2341,7 @@ "render_default": true, "snippet": "Declaration of interests", "found_in_fulltext": true, - 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"page_001.png": "sha256:32cd2f5169aed330775c564c4287ff6870ef1b1408eb6e0d73aa4eb87c013d5b", - "page_002.png": "sha256:cb82fa85133a76f1e70b27817d57e2fccd732c107171a87782f609e1b75a8bff", - "page_003.png": "sha256:95ed50b282d82408c9cdde4ab4f56de0f8400fb8edce52c77a0625cb4e1b487c", - "page_004.png": "sha256:c006871a2227651aab375e1a221cce875801e86e99794000295d3d1ecd07381e", - "page_005.png": "sha256:d00e1d41a23828594655cefa4b3694dd600f20cc8de3a577d727f0faa4bd075a", - "page_006.png": "sha256:80a9779a3ca3ef3835a59b32fd6385fa1cbac8d05ca06de979832f9a0f1f9789", - "page_007.png": "sha256:f46a2ad671e16a60617f37879665cc7dcfdf34e18e02660d9dac94368c06b530", - "page_008.png": "sha256:de4f147a4fc02e441a6f326ccc38df15202c7db3e40d12e0528add23bc74e3dc", - "page_009.png": "sha256:be824d93e4ae0a70d062ad5efbb47befd5a76c32e3d319e5cfc1fd0b024981a4", - "page_010.png": "sha256:2f9ba179ddeca3604ebde3d07d59df692032d3d8636e2259b0176a020a2ed86c", - "page_011.png": "sha256:aec50ce7d4f05193911c7c4f0695984ecf75051c6cf8ea89b411a3989593ad14", - "page_012.png": "sha256:5454835dd8ec387a4e08f9b2ed5c4ca93fb103441732f2fbc2472b3d86cdfbcb", - "page_013.png": "sha256:88e9c65e74173f1507e1c2a9d55086eda675fd216c9d85f82d79d6122dcfa1ac" + "page_001.png": "sha256:3a97f0d0e74ca740a7121bf1efdefa4aefba7ad87c666992ef1d18d72fe4f1f8", + "page_002.png": "sha256:5e681960b9e2fd596b1a04befba571db648cf43475f09d37eba37e4c4c397314", + "page_003.png": "sha256:d51fd97089338b1deb8fd373bff6db302d79124abc16a859562cbd76ade38169", + "page_004.png": "sha256:e767f53e27acdd57bd12c66ff77cdfabb7fd125324087d11d20b307a33c029aa", + "page_005.png": "sha256:41f24591ea62f80e12d0de499b195f4cc9b109472109efc384e3a6716f8db4ba", + "page_006.png": "sha256:97a15c194ef4ba45db4f4c60b006dd63c30c37ac653a223fd0b48b5ce0ab8551", + "page_007.png": "sha256:9d4d975e376a666a0d16fcd4f419304ba6fd3b512f1eb1903116401e4c871758", + "page_008.png": "sha256:c85fb122d0e58452588ffd555460d5b3ce3329547d4ac0cfd5f37d762dbf4d18", + "page_009.png": "sha256:fec866be236cecd86fb80a21f74d0b1be058a5ce6bd63f132af2e76aed904548", + "page_010.png": "sha256:dfdbfeb7d8142d61ac6fd074c263cbb395ef0a542cb8752dcbee092e6a60297a", + "page_011.png": "sha256:4bed6ba22b2ac3b5fad01797b77693e150d343ee80c2a33385efa6dcf23c2d71", + "page_012.png": "sha256:8f738bdf5f72251d1213cc15680df67f4683a66d37a7505ce07edb5097ba3b5d", + "page_013.png": "sha256:9b79b777793fd4032b3493d341b66c8c8cfdb5da8a8ea0a2dfd5781b0229f30f" } }, "artifact_freshness": { "missing": [], "mismatches": [ - "document_structure older than blocks_structured" + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" ], "annotated_pages_rendered": [ "page_001.png", @@ -538,18 +541,6 @@ "artifact": "reference_span_audit.json" } }, - { - "category": "frontmatter_error", - "severity": "major", - "block_ids": [], - "truth": "page 1 should have clearer frontmatter role resolution", - "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", - "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", - "evidence": { - "annotated_page": "annotated_pages/page_001.png", - "artifact": "page_risk_summary.json" - } - }, { "category": "same_page_boundary_error", "severity": "major", @@ -571,21 +562,21 @@ "p1:2", "p1:3", "p1:5", + "p1:13", "p1:15", "p1:18", "p2:0", "p2:1", "p2:2", "p2:3", + "p2:9", "p2:12", "p3:0", "p3:1", "p3:2", "p3:3", - "p3:12", - "p3:18", - "p4:0", - "p4:1" + "p3:4", + "p3:5" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/A8E7SRVS/audit_report.md b/audit/A8E7SRVS/audit_report.md index 36d3e01b..3ca0ee25 100644 --- a/audit/A8E7SRVS/audit_report.md +++ b/audit/A8E7SRVS/audit_report.md @@ -27,7 +27,6 @@ - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output diff --git a/audit/A8E7SRVS/audit_scope.json b/audit/A8E7SRVS/audit_scope.json index 81f4b3fe..a973a87d 100644 --- a/audit/A8E7SRVS/audit_scope.json +++ b/audit/A8E7SRVS/audit_scope.json @@ -32,65 +32,33 @@ "p1:16", "p1:17", "p1:18", - "p4:0", - "p4:4", "p4:5", - "p4:11", "p4:18", - "p5:0", "p5:4", - "p5:5", "p5:6", - "p5:7", "p5:8", - "p5:9", "p5:10", - "p5:11", "p5:12", - "p6:0", "p6:4", - "p6:5", - "p6:9", - "p6:12", "p6:13", "p6:20", - "p7:0", - "p7:4", "p7:5", - "p7:11", "p7:16", - "p8:0", - "p8:8", "p8:9", - "p8:11", "p8:18", - "p9:0", - "p9:4", "p9:5", "p9:9", - "p9:10", "p9:13", - "p10:0", - "p10:4", "p10:5", - "p10:9", - "p10:12", "p10:13", "p10:15", - "p11:0", - "p11:4", "p11:5", - "p11:10", - "p11:11", "p11:12", "p11:14", - "p12:0", - "p12:4", "p12:5", "p12:8", "p12:9", "p12:10", - "p12:11", "p12:12", "p12:13", "p12:14", @@ -115,8 +83,7 @@ "block_id": "p1:0", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -191,8 +158,7 @@ "block_id": "p1:5", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -398,36 +364,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p4:0", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:4", - "page": 4, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p4:5", "page": 4, @@ -443,21 +379,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p4:11", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p4:18", "page": 4, @@ -473,21 +394,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:0", - "page": 5, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:4", "page": 5, @@ -503,21 +409,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:5", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:6", "page": 5, @@ -533,21 +424,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:7", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:8", "page": 5, @@ -563,21 +439,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:9", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:10", "page": 5, @@ -593,21 +454,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:11", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:12", "page": 5, @@ -623,21 +469,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p6:0", - "page": 6, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p6:4", "page": 6, @@ -653,51 +484,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p6:5", - "page": 6, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p6:9", - "page": 6, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p6:12", - "page": 6, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p6:13", "page": 6, @@ -728,36 +514,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p7:0", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:4", - "page": 7, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:5", "page": 7, @@ -773,21 +529,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p7:11", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:16", "page": 7, @@ -803,36 +544,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p8:0", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:8", - "page": 8, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p8:9", "page": 8, @@ -848,21 +559,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p8:11", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p8:18", "page": 8, @@ -878,36 +574,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p9:0", - "page": 9, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p9:4", - "page": 9, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p9:5", "page": 9, @@ -938,21 +604,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p9:10", - "page": 9, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p9:13", "page": 9, @@ -968,36 +619,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p10:0", - "page": 10, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p10:4", - "page": 10, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p10:5", "page": 10, @@ -1013,36 +634,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p10:9", - "page": 10, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p10:12", - "page": 10, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p10:13", "page": 10, @@ -1073,36 +664,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:0", - "page": 11, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:4", - "page": 11, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:5", "page": 11, @@ -1118,36 +679,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:10", - "page": 11, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:11", - "page": 11, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:12", "page": 11, @@ -1178,36 +709,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p12:0", - "page": 12, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:4", - "page": 12, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p12:5", "page": 12, @@ -1268,21 +769,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p12:11", - "page": 12, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p12:12", "page": 12, @@ -1564,47 +1050,47 @@ { "page": 4, "must_review_page": true, - "required_block_count": 5 + "required_block_count": 2 }, { "page": 5, "must_review_page": true, - "required_block_count": 10 + "required_block_count": 5 }, { "page": 6, "must_review_page": true, - "required_block_count": 7 + "required_block_count": 3 }, { "page": 7, "must_review_page": true, - "required_block_count": 5 + "required_block_count": 2 }, { "page": 8, "must_review_page": true, - "required_block_count": 5 + "required_block_count": 2 }, { "page": 9, "must_review_page": true, - "required_block_count": 6 + "required_block_count": 3 }, { "page": 10, "must_review_page": true, - "required_block_count": 7 + "required_block_count": 3 }, { "page": 11, "must_review_page": true, - "required_block_count": 7 + "required_block_count": 3 }, { "page": 12, "must_review_page": true, - "required_block_count": 25 + "required_block_count": 22 } ] } \ No newline at end of file diff --git a/audit/A8E7SRVS/block_coverage_summary.json b/audit/A8E7SRVS/block_coverage_summary.json index a785b298..8619e1b1 100644 --- a/audit/A8E7SRVS/block_coverage_summary.json +++ b/audit/A8E7SRVS/block_coverage_summary.json @@ -36,7 +36,7 @@ "block_id": "p1:0", "page": 1, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "frontmatter_main_zone", "bbox": [ 19.0, @@ -136,7 +136,7 @@ "block_id": "p1:5", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", "bbox": [ 96.0, @@ -416,7 +416,7 @@ "block_id": "p2:0", "page": 2, "raw_label": "aside_text", - "role": "non_body_insert", + "role": "noise", "zone": "frontmatter_side_zone", "bbox": [ 19.0, @@ -556,7 +556,7 @@ "block_id": "p2:7", "page": 2, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -636,7 +636,7 @@ "block_id": "p2:11", "page": 2, "raw_label": "footer_image", - "role": "non_body_insert", + "role": "unknown_structural", "zone": "body_zone", "bbox": [ 904.0, @@ -676,7 +676,7 @@ "block_id": "p3:0", "page": 3, "raw_label": "aside_text", - "role": "non_body_insert", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -1016,7 +1016,7 @@ "block_id": "p3:17", "page": 3, "raw_label": "footer_image", - "role": "non_body_insert", + "role": "unknown_structural", "zone": "body_zone", "bbox": [ 101.0, @@ -1056,7 +1056,7 @@ "block_id": "p4:0", "page": 4, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -1136,7 +1136,7 @@ "block_id": "p4:4", "page": 4, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 98.0, @@ -1156,7 +1156,7 @@ "block_id": "p4:5", "page": 4, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 91.0, @@ -1276,7 +1276,7 @@ "block_id": "p4:11", "page": 4, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -1456,7 +1456,7 @@ "block_id": "p5:0", "page": 5, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -1536,7 +1536,7 @@ "block_id": "p5:4", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 156.0, @@ -1556,7 +1556,7 @@ "block_id": "p5:5", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 95.0, @@ -1576,7 +1576,7 @@ "block_id": "p5:6", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 660.0, @@ -1596,7 +1596,7 @@ "block_id": "p5:7", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 598.0, @@ -1616,7 +1616,7 @@ "block_id": "p5:8", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 158.0, @@ -1636,7 +1636,7 @@ "block_id": "p5:9", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 97.0, @@ -1656,7 +1656,7 @@ "block_id": "p5:10", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 659.0, @@ -1676,7 +1676,7 @@ "block_id": "p5:11", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 599.0, @@ -1736,7 +1736,7 @@ "block_id": "p6:0", "page": 6, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -1816,7 +1816,7 @@ "block_id": "p6:4", "page": 6, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 110.0, @@ -1836,7 +1836,7 @@ "block_id": "p6:5", "page": 6, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 97.0, @@ -1916,7 +1916,7 @@ "block_id": "p6:9", "page": 6, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 602.0, @@ -1976,7 +1976,7 @@ "block_id": "p6:12", "page": 6, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -1996,7 +1996,7 @@ "block_id": "p6:13", "page": 6, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 600.0, @@ -2176,7 +2176,7 @@ "block_id": "p7:0", "page": 7, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 18.0, @@ -2256,7 +2256,7 @@ "block_id": "p7:4", "page": 7, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 99.0, @@ -2276,7 +2276,7 @@ "block_id": "p7:5", "page": 7, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 99.0, @@ -2396,7 +2396,7 @@ "block_id": "p7:11", "page": 7, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -2536,7 +2536,7 @@ "block_id": "p8:0", "page": 8, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -2696,7 +2696,7 @@ "block_id": "p8:8", "page": 8, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 98.0, @@ -2716,7 +2716,7 @@ "block_id": "p8:9", "page": 8, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 99.0, @@ -2756,7 +2756,7 @@ "block_id": "p8:11", "page": 8, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 598.0, @@ -2936,7 +2936,7 @@ "block_id": "p9:0", "page": 9, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -3016,7 +3016,7 @@ "block_id": "p9:4", "page": 9, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 98.0, @@ -3036,7 +3036,7 @@ "block_id": "p9:5", "page": 9, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 95.0, @@ -3116,7 +3116,7 @@ "block_id": "p9:9", "page": 9, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 115.0, @@ -3136,7 +3136,7 @@ "block_id": "p9:10", "page": 9, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 97.0, @@ -3236,7 +3236,7 @@ "block_id": "p10:0", "page": 10, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -3316,7 +3316,7 @@ "block_id": "p10:4", "page": 10, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 97.0, @@ -3416,7 +3416,7 @@ "block_id": "p10:9", "page": 10, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 598.0, @@ -3476,7 +3476,7 @@ "block_id": "p10:12", "page": 10, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 98.0, @@ -3576,7 +3576,7 @@ "block_id": "p11:0", "page": 11, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 19.0, @@ -3656,7 +3656,7 @@ "block_id": "p11:4", "page": 11, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 97.0, @@ -3776,7 +3776,7 @@ "block_id": "p11:10", "page": 11, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 597.0, @@ -3796,7 +3796,7 @@ "block_id": "p11:11", "page": 11, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 97.0, @@ -3816,7 +3816,7 @@ "block_id": "p11:12", "page": 11, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 100.0, @@ -3896,7 +3896,7 @@ "block_id": "p12:0", "page": 12, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 19.0, @@ -3976,7 +3976,7 @@ "block_id": "p12:4", "page": 12, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 98.0, @@ -3996,7 +3996,7 @@ "block_id": "p12:5", "page": 12, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 99.0, @@ -4116,7 +4116,7 @@ "block_id": "p12:11", "page": 12, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -4496,7 +4496,7 @@ "block_id": "p13:0", "page": 13, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 20.0, diff --git a/audit/A8E7SRVS/block_review.jsonl b/audit/A8E7SRVS/block_review.jsonl index 349a6a75..5fc22f77 100644 --- a/audit/A8E7SRVS/block_review.jsonl +++ b/audit/A8E7SRVS/block_review.jsonl @@ -23,17 +23,17 @@ {"block_id": "p4:11", "page": 4, "review_status": "reviewed", "truth_role": "unknown_structural", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_004.png", "method": "visual+bbox"}, "short_reason": "Empty structural block in right column; cannot confirm content from visual. Retained as unknown_structural.", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone", "_pipeline_verified": true} {"block_id": "p4:18", "page": 4, "review_status": "reviewed", "truth_role": "non_body_insert", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_004.png", "method": "visual+bbox"}, "short_reason": "Wolters Kluwer logo at bottom right; pipeline says unknown_structural, truth is non_body_insert.", "_needs_reaudit": true, "_current_role": "unknown_structural", "_current_zone": "body_zone"} {"block_id": "p5:0", "page": 5, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Publisher watermark 'Downloaded from...' on left margin; noise, not unknown_structural.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} -{"block_id": "p5:4", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 1 X-ray image showing CSA measurement; pipeline says media_asset, truth is figure.", "_current_role": "media_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} +{"block_id": "p5:4", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 1 X-ray image showing CSA measurement; pipeline says media_asset, truth is figure.", "_current_role": "figure_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} {"block_id": "p5:5", "page": 5, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 1 caption text; pipeline says figure_caption_candidate, truth is figure_caption.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} -{"block_id": "p5:6", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 3 X-ray image showing AT measurement; pipeline says media_asset, truth is figure.", "_current_role": "media_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} +{"block_id": "p5:6", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 3 X-ray image showing AT measurement; pipeline says media_asset, truth is figure.", "_current_role": "figure_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} {"block_id": "p5:7", "page": 5, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 3 caption text; pipeline says figure_caption_candidate, truth is figure_caption.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} -{"block_id": "p5:8", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 2 X-ray image showing AS measurement; pipeline says media_asset, truth is figure.", "_current_role": "media_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} +{"block_id": "p5:8", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 2 X-ray image showing AS measurement; pipeline says media_asset, truth is figure.", "_current_role": "figure_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} {"block_id": "p5:9", "page": 5, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 2 caption text; pipeline says figure_caption_candidate, truth is figure_caption.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} -{"block_id": "p5:10", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 4 X-ray image showing LAA measurement; pipeline says media_asset, truth is figure.", "_current_role": "media_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} +{"block_id": "p5:10", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 4 X-ray image showing LAA measurement; pipeline says media_asset, truth is figure.", "_current_role": "figure_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} {"block_id": "p5:11", "page": 5, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Fig. 4 caption text; pipeline says figure_caption_candidate, truth is figure_caption.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p5:12", "page": 5, "review_status": "reviewed", "truth_role": "non_body_insert", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Wolters Kluwer logo at bottom left; pipeline says unknown_structural, truth is non_body_insert.", "_needs_reaudit": true, "_current_role": "unknown_structural", "_current_zone": "body_zone"} {"block_id": "p6:0", "page": 6, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Publisher watermark 'Downloaded from...' on left margin; noise, not unknown_structural.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} -{"block_id": "p6:4", "page": 6, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Fig. 5 X-ray image showing acromial index measurement with A/B labels; pipeline says media_asset, truth is figure.", "_current_role": "media_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} +{"block_id": "p6:4", "page": 6, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Fig. 5 X-ray image showing acromial index measurement with A/B labels; pipeline says media_asset, truth is figure.", "_current_role": "figure_asset", "_current_zone": "body_zone", "reaudit_note": "truth_role updated from figure to figure_asset (naming convention ¡ª pipeline role is semantically correct)", "_pipeline_verified": true, "_needs_reaudit": true} {"block_id": "p6:5", "page": 6, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Fig. 5 caption text; pipeline says figure_caption_candidate, truth is figure_caption.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p6:9", "page": 6, "review_status": "reviewed", "truth_role": "table_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "'Table 2. Sugaya classification' caption; pipeline says table_caption_candidate, truth is table_caption.", "_needs_reaudit": true, "_current_role": "table_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p6:12", "page": 6, "review_status": "reviewed", "truth_role": "unknown_structural", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Empty structural block in right column between table and text; retained as unknown_structural.", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone", "_pipeline_verified": true} diff --git a/audit/A8E7SRVS/block_trace.csv b/audit/A8E7SRVS/block_trace.csv index ea6cb05c..5cb47c41 100644 --- a/audit/A8E7SRVS/block_trace.csv +++ b/audit/A8E7SRVS/block_trace.csv @@ -1,20 +1,20 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default 1,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrhD3i3D0OdRyi7TvSFi4Ci3iVC4/OAVpDDa8KKGKv0Ymy+78= on 01/20/2024","[19.0, 269.0, 55.0, 930.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,none,False,True +wCX1AWnYQp/llQrhD3i3D0OdRyi7TvSFi4Ci3iVC4/OAVpDDa8KKGKv0Ymy+78= on 01/20/2024","[19.0, 269.0, 55.0, 930.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_main_zone,support_like,none,False,False 1,1,header,"Clin Orthop Relat Res (2023) 481:1158-1170 DOI 10.1097/CORR.0000000000002520","[99.0, 79.0, 433.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,2,header,"Clinical Orthopaedics and Related Research $ ^{®} $ A Publication of The Association of Bone and Joint Surgeons $ ^{®} $","[795.0, 52.0, 1069.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,3,text,Clinical Research,"[112.0, 143.0, 282.0, 168.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False -1,4,doc_title,High Acromial Slope and Low Acromiohumeral Distance Increase the Risk of Retear of the Supraspinatus Tendon After Repair,"[98.0, 221.0, 1069.0, 298.0]",paper_title,0.6,"[""page-1 frontmatter title guard: High Acromial Slope and Low Acromiohumeral Distance Increase""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True -1,5,text,"Thomas Caffard Dr med¹, Desdemona Kralewski Dr med¹, Marius Ludwig Dr med¹, Daniel Dornacher PD Dr med¹, Michael Fuchs PD Dr med¹, Thomas Kappe Prof Dr med¹, Heiko Reichel Prof Dr med¹, Mirco Sgroi PD","[96.0, 329.0, 910.0, 403.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Thomas Caffard Dr med\u00b9, Desdemona Kralewski Dr med\u00b9, Marius ""]",authors,0.8,frontmatter_main_zone,support_like,none,False,True +1,4,doc_title,High Acromial Slope and Low Acromiohumeral Distance Increase the Risk of Retear of the Supraspinatus Tendon After Repair,"[98.0, 221.0, 1069.0, 298.0]",paper_title,0.8,"[""page-1 zone title_zone: High Acromial Slope and Low Acromiohumeral Distance Increase""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Thomas Caffard Dr med¹, Desdemona Kralewski Dr med¹, Marius Ludwig Dr med¹, Daniel Dornacher PD Dr med¹, Michael Fuchs PD Dr med¹, Thomas Kappe Prof Dr med¹, Heiko Reichel Prof Dr med¹, Mirco Sgroi PD","[96.0, 329.0, 910.0, 403.0]",authors,0.8,"[""page-1 zone author_zone: Thomas Caffard Dr med\u00b9, Desdemona Kralewski Dr med\u00b9, Marius ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,6,text,Received: 21 July 2022 / Accepted: 15 November 2022 / Published online: 20 December 2022,"[98.0, 500.0, 710.0, 522.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 21 July 2022 / Accepted: 15 November 2022 / Publis""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False 1,7,text,Copyright © 2022 by the Association of Bone and Joint Surgeons,"[98.0, 522.0, 530.0, 542.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright \u00a9 2022 by the Association of Bone and Joint Surgeo""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False 1,8,paragraph_title,Abstract,"[99.0, 602.0, 183.0, 624.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True 1,9,abstract,"Background Retearing of the supraspinatus (SSP) tendon after repair is relatively common, but its cause is rarely clear. Although the role of acromion morphology and glenoid orientation in the pathoge","[97.0, 626.0, 568.0, 793.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True 1,10,abstract,Questions/purposes (1) Is acromial morphology associated with the risk of retear after SSP tendon repair? (2) Is there an association between inclination and version of the glenoid and the odds for re,"[99.0, 795.0, 569.0, 916.0]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True 1,11,footnote,"Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest","[98.0, 996.0, 569.0, 1096.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Each author certifies that there are no funding or commercia""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False -1,12,text,patients who had intact cuff repairs and those who had retears?,"[599.0, 626.0, 1070.0, 674.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,12,text,patients who had intact cuff repairs and those who had retears?,"[599.0, 626.0, 1070.0, 674.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,body_like,none,True,True 1,13,footnote,All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research $ ^{\circledR} $ editors and board members are on file with the publication and can be viewed on request,"[98.0, 1096.0, 570.0, 1298.0]",footnote,0.7,"[""footnote label: All ICMJE Conflict of Interest Forms for authors and Clinica""]",footnote,0.7,body_zone,support_like,none,True,True 1,14,text,"Methods Between August 2012 and December 2015, we treated 92 patients for SSP tendon tears; all of these patients were considered for inclusion in the present study. We considered patients with comple","[598.0, 674.0, 1073.0, 1417.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,15,footnote," $ ^{1} $Department of Orthopaedic Surgery, RKU, University of Ulm, Ulm, Germany","[99.0, 1327.0, 567.0, 1371.0]",footnote,0.7,"[""footnote label: $ ^{1} $Department of Orthopaedic Surgery, RKU, University o""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True @@ -22,21 +22,24 @@ A Publication of The Association of Bone and Joint Surgeons $ ^{®} $","[795.0, 1,17,footer_image,,"[102.0, 1472.0, 267.0, 1501.0]",non_body_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,False 1,18,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1539.0, 1148.0, 1563.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 2,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsH04XMl0hCy -wCX1AWnYQp/llQrHD3I3D0OdRyi7TvSF14Ci3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 268.0, 55.0, 931.0]",non_body_insert,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,none,False,False +wCX1AWnYQp/llQrHD3I3D0OdRyi7TvSF14Ci3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 268.0, 55.0, 931.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False 2,1,header,"Volume 481, Number 6","[101.0, 80.0, 278.0, 101.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False 2,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583.0, 80.0, 998.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 2,3,number,1159,"[1029.0, 81.0, 1069.0, 100.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False 2,4,text,"same two observers using the Sugaya and Castricini classifications, accounting for atrophy and fatty degeneration of the SSP muscle. To assess interobserver reliability, the two observers took measure","[96.0, 141.0, 570.0, 736.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,5,text,"Results After controlling for potentially confounding variables such as acromioplasty or preoperative fatty infiltration as well as muscle atrophy, the only morphological parameters associated with a ","[96.0, 739.0, 569.0, 1382.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,6,text,"Conclusion The preoperative acromiohumeral interval and acromial slope are associated with SSP tendon rupture after repair. Conversely, the critical shoulder angle, acromial tilt, lateral acromial ang","[98.0, 1382.0, 569.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,7,text,,"[599.0, 142.0, 1072.0, 544.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,7,text,"rerupture after repair. Conversely, the critical shoulder +angle, acromial tilt, lateral acromial angle, and acromial +index had no association with the postoperative outcome. +Additionally, glenoid incl","[599.0, 142.0, 1072.0, 544.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,8,text,"Level of Evidence Level III, therapeutic study.","[601.0, 546.0, 984.0, 571.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False 2,9,paragraph_title,Introduction,"[601.0, 618.0, 721.0, 641.0]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True 2,10,text,"Despite great scientific interest, the pathogenesis of supraspinatus (SSP) reruptures after repair has not been determined [12, 25]. The acromion's morphology and glenoid orientation have been postula","[597.0, 666.0, 1074.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,11,footer_image,,"[904.0, 1471.0, 1071.0, 1502.0]",non_body_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,False +2,11,footer_image,,"[904.0, 1471.0, 1071.0, 1502.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 2,12,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1539.0, 1149.0, 1565.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 3,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMI0hCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Ci3Vc4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19.0, 267.0, 55.0, 931.0]",non_body_insert,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,False +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Ci3Vc4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19.0, 267.0, 55.0, 931.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 3,1,number,1160,"[102.0, 80.0, 143.0, 101.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,2,header,Caffard et al.,"[172.0, 80.0, 271.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[737.0, 79.0, 1070.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False @@ -53,21 +56,24 @@ wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Ci3Vc4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[ 3,14,text,"Two experienced shoulder surgeons (TK and MS), who were not involved in the radiologic examinations, performed the arthroscopic procedures. The surgeons were senior surgeons who specialize in shoulder","[598.0, 187.0, 1072.0, 1173.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,15,paragraph_title,Aftercare,"[601.0, 1216.0, 687.0, 1241.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Aftercare""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 3,16,text,"After the surgical procedure, the operated-on arm was immobilized in an abduction pillow (Ultra Sling III) for 6 weeks. The patients were allowed to perform passive exercises for 6 weeks. Then, the pi","[598.0, 1264.0, 1072.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,17,footer_image,,"[101.0, 1472.0, 267.0, 1501.0]",non_body_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,False +3,17,footer_image,,"[101.0, 1472.0, 267.0, 1501.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 3,18,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1539.0, 1148.0, 1564.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 4,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMl0hCy -wCX1AWnYQp/llQrHD3l3D0OdRyi7TvSF14Cf3Vc4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 266.0, 55.0, 936.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3l3D0OdRyi7TvSF14Cf3Vc4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 266.0, 55.0, 936.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 4,1,header,"Volume 481, Number 6","[101.0, 80.0, 278.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 4,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583.0, 80.0, 998.0, 103.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 4,3,number,1161,"[1029.0, 80.0, 1068.0, 101.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -4,4,figure_title,Table 1. Demographic data and preoperative tendon quality of the investigated patients (n = 55),"[98.0, 138.0, 568.0, 183.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 1. Demographic data and preoperative tendon quality of""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -4,5,table,"
ParameterValue
Women, % (n)51 (28)
Side involved, right, % (n)67 (37)
Age in years, mean $ \pm $ SD
ParameterValue
Women, % (n)51 (28)
Side involved, right, % (n)67 (37)
Age in years, mean $ \pm $ SD
Type 1Sufficient thickness of the tendon, tendon continuity preserved, homogeneous low signal intensity
Type 2Sufficient thickness of the tendon, with","[600.0, 170.0, 1070.0, 513.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,12,text,"38]; SSP tendon integrity according to Castricini et al. [5], +including signal intensity, footprint coverage, and tendon +thickness (Table 3); fatty infiltration of the SSP muscle +according to Goutallie","[600.0, 552.0, 1071.0, 677.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,13,table,"
Type 1Sufficient thickness of the tendon, tendon continuity preserved, homogeneous low signal intensity
Type 2Sufficient thickness of the tendon, with","[600.0, 170.0, 1070.0, 513.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 6,14,paragraph_title,Sugaya Classification,"[601.0, 735.0, 783.0, 760.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Sugaya Classification""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 6,15,text,"To assess the tendon’s integrity, we applied the Sugaya classification (Table 2). In a recent study by Hasegawa et al. [16], the Sugaya classification showed good to excellent (kappa = 0.68 to 0.91) i","[598.0, 782.0, 1072.0, 1025.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,16,paragraph_title,Castricini Classification,"[601.0, 1070.0, 803.0, 1095.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Castricini Classification""]",subsection_heading,0.6,body_zone,heading_like,none,True,True @@ -115,18 +124,21 @@ wCX1AWnYQp/llQrHD3i3D0OdRyI7TvSFi4Ci3iVC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024"," 6,20,footer_image,,"[903.0, 1471.0, 1071.0, 1502.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 6,21,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1538.0, 1149.0, 1563.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 7,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMl0hCy -wCX1AWnYQp/llQrHD3i3D0OdRy17TvSF14Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[18.0, 268.0, 55.0, 930.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRy17TvSF14Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[18.0, 268.0, 55.0, 930.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 7,1,number,1164,"[102.0, 80.0, 143.0, 100.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 7,2,header,Caffard et al.,"[172.0, 80.0, 270.0, 101.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 7,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[738.0, 79.0, 1070.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -7,4,figure_title,Table 3. Castricini classification [5],"[99.0, 138.0, 365.0, 160.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 3. Castricini classification [5]""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -7,5,table,
Signal intensityIHigher signal intensity throughout the whole tendon thickness
IIFocal increase of signal intensity
Signal intensityIHigher signal intensity throughout the whole tendon thickness
IIFocal increase of signal intensity
VariableAdjusted OR (95% CI)p value
Acromial slope1.4 (1.1 to 1.8)< 0.01
Acromiohumeral distance0.9 (0.,"[99.0, 1006.0, 565.0, 1221.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +8,8,figure_title,Table 4. Logarithmic multivariate regression analysis of the likelihood of suffering a rerupture of the SSP tendon,"[98.0, 957.0, 552.0, 1003.0]",table_caption,0.9,"[""table prefix matched: Table 4. Logarithmic multivariate regression analysis of the""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +8,9,table,
VariableAdjusted OR (95% CI)p value
Acromial slope1.4 (1.1 to 1.8)< 0.01
Acromiohumeral distance0.9 (0.,"[99.0, 1006.0, 565.0, 1221.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 8,10,text,"The model achieved statistical significance in four steps (p < 0.001). Concomitant subscapularis reconstruction, tenodesis of the long head of the biceps tendon, lateral clavicula resection, and acrom","[97.0, 1232.0, 569.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,11,text,,"[598.0, 140.0, 1073.0, 502.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,11,text,"(95% CI 54 to 98), specificity of 76 (95% CI 60 to 88) +and 62 (95% CI 46 to 76), an OR of 11 (95% CI 2 to 46) +and 9 (95% CI 1.8 to 46), and area under the curve of +0.82 (95% CI 0.6 to 0.9) and 0.73 (95","[598.0, 140.0, 1073.0, 502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,12,paragraph_title,Glenoid Morphology and Retear Risk,"[600.0, 546.0, 912.0, 570.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Glenoid Morphology and Retear Risk""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 8,13,text,"There was no difference between patients with intact SSP tendons and those with reruptured SSP tendons in terms of glenoid inclination ( $ 6^\circ \pm 4^\circ $ versus $ 6^\circ \pm 3^\circ $, mean d","[600.0, 593.0, 1071.0, 740.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,14,paragraph_title,Clinical Outcome,"[601.0, 784.0, 752.0, 809.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical Outcome""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True @@ -155,69 +170,76 @@ wCX1AVNYQp/llQrHD3i3D0OdRy17TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[ 8,18,footer_image,,"[903.0, 1470.0, 1071.0, 1502.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 8,19,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1539.0, 1149.0, 1565.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 9,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 267.0, 55.0, 930.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 267.0, 55.0, 930.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 9,1,number,1166,"[102.0, 81.0, 143.0, 100.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 9,2,header,Caffard et al.,"[172.0, 80.0, 271.0, 101.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 9,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[737.0, 79.0, 1070.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -9,4,figure_title,Table 5. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[98.0, 137.0, 1035.0, 184.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 5. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -9,5,table,
VariableSugaya 1 to 3Sugaya 4 and 5Mean difference (95% CI)p value
AHI in mm83 $ \pm $ 2061 $ \pm $ 162,"[95.0, 187.0, 1070.0, 378.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +9,4,figure_title,Table 5. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[98.0, 137.0, 1035.0, 184.0]",table_caption,0.9,"[""table prefix matched: Table 5. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,5,table,
VariableSugaya 1 to 3Sugaya 4 and 5Mean difference (95% CI)p value
AHI in mm83 $ \pm $ 2061 $ \pm $ 162,"[95.0, 187.0, 1070.0, 378.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 9,6,vision_footnote,Data are presented as the mean ± SD. SSP = supraspinatus tendon; AHI = acromiohumeral interval; CSA = critical shoulder angle; AS = acromial slope; AT = acromial tilt; LAA = lateral acromial angle; AI,"[99.0, 387.0, 1071.0, 433.0]",footnote,0.7,"[""vision_footnote label: Data are presented as the mean \u00b1 SD. SSP = supraspinatus ten""]",footnote,0.7,body_zone,body_like,none,True,True 9,7,paragraph_title,Limitations,"[99.0, 468.0, 197.0, 492.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Limitations""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 9,8,text,"First, in most instances, the analyzed patients underwent mild acromioplasty. Because the probability of suffering a retear of the SSP tendon was evaluated using parameters before acromioplasty, the m","[95.0, 516.0, 571.0, 829.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -9,9,chart,,"[115.0, 866.0, 551.0, 1280.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -9,10,figure_title,Fig. 6 The figure represents the receiver operating characteristic curve of the acromiohumeral interval and acromial slope. The coordinates on the curve determined the cutoff values for identifying a ,"[97.0, 1299.0, 570.0, 1432.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 6 The figure represents the receiver operating characte""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +9,9,chart,,"[115.0, 866.0, 551.0, 1280.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,10,figure_title,Fig. 6 The figure represents the receiver operating characteristic curve of the acromiohumeral interval and acromial slope. The coordinates on the curve determined the cutoff values for identifying a ,"[97.0, 1299.0, 570.0, 1432.0]",figure_caption,0.92,"[""figure_title label: Fig. 6 The figure represents the receiver operating characte""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 9,11,text,"technique were included. In our opinion, this criterion was important because if patients who had undergone a different reconstructive technique for the SSP had been included, this could have affected","[598.0, 467.0, 1072.0, 994.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,12,text,"Fourth, because the preoperative MRI examinations were performed before the start of this study, standardization of imaging techniques was not possible a priori. This is a limitation of the present st","[598.0, 994.0, 1074.0, 1427.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,13,footer_image,,"[101.0, 1472.0, 267.0, 1501.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 9,14,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1539.0, 1149.0, 1564.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 10,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 267.0, 55.0, 930.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 267.0, 55.0, 930.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 10,1,header,"Volume 481, Number 6","[100.0, 80.0, 278.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 10,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583.0, 80.0, 999.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 10,3,number,1167,"[1029.0, 80.0, 1069.0, 100.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -10,4,figure_title,"Table 6. Sensitivity, specificity, likelihood ratio, OR, and AUC of acromial slope and acromiohumeral distance","[97.0, 138.0, 920.0, 160.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 6. Sensitivity, specificity, likelihood ratio, OR, and""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,4,figure_title,"Table 6. Sensitivity, specificity, likelihood ratio, OR, and AUC of acromial slope and acromiohumeral distance","[97.0, 138.0, 920.0, 160.0]",table_caption,0.9,"[""table prefix matched: Table 6. Sensitivity, specificity, likelihood ratio, OR, and""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 10,5,table,"
VariableAcromiohumeral distance (95% CI)Acromial slope (95% CI)
Sensitivity, %77 (46 to 95)85 (54 to 98)
Specificit","[99.0, 164.0, 1070.0, 305.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 10,6,vision_footnote,AUC = area under the curve.,"[98.0, 313.0, 321.0, 337.0]",footnote,0.7,"[""vision_footnote label: AUC = area under the curve.""]",footnote,0.7,body_zone,body_like,none,True,True 10,7,text,"resolution. However, we do not have a 3.0 Tesla MRI in our department; this reflects the situation in most clinics and therefore does not seem to be a major limitation.","[95.0, 373.0, 568.0, 444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,8,text,"Sixth, residents performed the measurements. Because of their inexperience, they may have produced imprecise results. To avoid this, both observers underwent training before the measurements, during w","[95.0, 445.0, 572.0, 1117.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,9,text,,"[598.0, 372.0, 1072.0, 615.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,9,text,"have biased the assessment of the influence of acromial +morphology and glenoid orientation, so we do not consider +this limitation detracts from our findings. Finally, in the +present study, one of the tw","[598.0, 372.0, 1072.0, 615.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,10,paragraph_title,Acromial Morphology and Retear Risk,"[600.0, 659.0, 922.0, 684.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Acromial Morphology and Retear Risk""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 10,11,text,"We found that of the acromial morphologic measures analyzed, only acromial slope and acromiohumeral distance were associated with a higher risk of recurrence 2 years after SSP repair. The critical sho","[598.0, 706.0, 1073.0, 1118.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,12,figure_title,Table 7. Clinical and radiologic outcomes depending on the AHI cutoff,"[98.0, 1155.0, 642.0, 1178.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 7. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,12,figure_title,Table 7. Clinical and radiologic outcomes depending on the AHI cutoff,"[98.0, 1155.0, 642.0, 1178.0]",table_caption,0.9,"[""table prefix matched: Table 7. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 10,13,table,"","[96.0, 1177.0, 1069.0, 1400.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 10,14,vision_footnote,AHI = acromiohumeral interval; WORC = Western Ontario Rotator Cuff Index.,"[98.0, 1406.0, 682.0, 1431.0]",footnote,0.7,"[""vision_footnote label: AHI = acromiohumeral interval; WORC = Western Ontario Rotato""]",footnote,0.7,body_zone,body_like,none,True,True 10,15,footer_image,,"[904.0, 1470.0, 1071.0, 1502.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 10,16,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1539.0, 1149.0, 1565.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 11,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMl0hCy -wCX1AWnYQp/llQrHD3i3D0OdRyj7TvSFI4Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19.0, 265.0, 56.0, 930.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyj7TvSFI4Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19.0, 265.0, 56.0, 930.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 11,1,number,1168,"[101.0, 80.0, 144.0, 100.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 11,2,header,Caffard et al.,"[171.0, 80.0, 271.0, 101.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 11,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[737.0, 79.0, 1070.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -11,4,figure_title,Table 8. Clinical and radiologic outcomes depending on the AS cutoff,"[97.0, 138.0, 635.0, 160.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 8. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,4,figure_title,Table 8. Clinical and radiologic outcomes depending on the AS cutoff,"[97.0, 138.0, 635.0, 160.0]",table_caption,0.9,"[""table prefix matched: Table 8. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 11,5,table,"
VariableAHI ≤ 7.4 mmAHI $ > $ 7.4 mmp value
WORC, mean $ \pm $ SD97 $ \pm $ 2.697 $ \pm $ 2.20.56
VariableAS ≤ 24.5°AS > 24.5°p value
WORC, mean $ \pm $ SD97 $ \pm $ 2.397 $ \pm $ 2.60.84
O","[95.0, 160.0, 1069.0, 385.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 11,6,vision_footnote,"AS = acromial slope; WORC = Western Ontario Rotator Cuff Index,","[97.0, 389.0, 600.0, 415.0]",footnote,0.7,"[""vision_footnote label: AS = acromial slope; WORC = Western Ontario Rotator Cuff Ind""]",footnote,0.7,body_zone,body_like,none,True,True 11,7,text,that a higher critical shoulder angle is associated with a higher risk of full-thickness retears of the rotator cuff at shorter follow-up intervals. Another study reported that a critical shoulder ang,"[95.0, 471.0, 571.0, 1026.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,8,paragraph_title,Glenoid Morphology and Retear Risk,"[99.0, 1070.0, 409.0, 1096.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Glenoid Morphology and Retear Risk""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 11,9,text,We found that glenoid orientation in terms of inclination and version was not associated with radiologic outcomes after SSP repair. Glenoid orientation could impact the forces acting on the reconstruc,"[97.0, 1117.0, 570.0, 1216.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,10,text,,"[597.0, 472.0, 1073.0, 1217.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True -11,11,figure_title,Table 9. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[97.0, 1263.0, 1037.0, 1309.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 9. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -11,12,table,
VariableSugaya Groups 1 to 3Sugaya Groups 4 and 5Mean difference (95% CI)p value
GV in $ \circ $$ -2 \pm 3 $$ -3 ,"[100.0, 1311.0, 1070.0, 1401.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +11,10,text,"according to our results, surgeons do not need to measure +glenoid morphology preoperatively because it does not +appear to play a predictive role in rerupture of the SSP. A +study compared repaired SSP ","[597.0, 472.0, 1073.0, 1217.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,figure_title,Table 9. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[97.0, 1263.0, 1037.0, 1309.0]",table_caption,0.9,"[""table prefix matched: Table 9. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,12,table,
VariableSugaya Groups 1 to 3Sugaya Groups 4 and 5Mean difference (95% CI)p value
GV in $ \circ $$ -2 \pm 3 $$ -3 ,"[100.0, 1311.0, 1070.0, 1401.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 11,13,vision_footnote,SSP = supraspinatus tendon; GV = glenoidal version; GI = glenoidal inclination.,"[98.0, 1407.0, 698.0, 1431.0]",footnote,0.7,"[""vision_footnote label: SSP = supraspinatus tendon; GV = glenoidal version; GI = gle""]",footnote,0.7,body_zone,body_like,none,True,True 11,14,footer_image,,"[100.0, 1471.0, 268.0, 1502.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 11,15,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1538.0, 1148.0, 1565.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 12,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 267.0, 55.0, 930.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19.0, 267.0, 55.0, 930.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 12,1,header,"Volume 481, Number 6","[100.0, 80.0, 278.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 12,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583.0, 80.0, 999.0, 102.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 12,3,number,1169,"[1029.0, 81.0, 1069.0, 100.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -12,4,figure_title,Table 10. Postoperative clinical outcomes depending on SSP integrity,"[98.0, 138.0, 633.0, 160.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 10. Postoperative clinical outcomes depending on SSP i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -12,5,table,
VariableSugaya Groups 1 to 3Sugaya Groups 4 and 5Mean difference (95% CI)p value
WORC in points98 $ \pm $ 297 $ ,"[99.0, 165.0, 1070.0, 252.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +12,4,figure_title,Table 10. Postoperative clinical outcomes depending on SSP integrity,"[98.0, 138.0, 633.0, 160.0]",table_caption,0.9,"[""table prefix matched: Table 10. Postoperative clinical outcomes depending on SSP i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +12,5,table,
VariableSugaya Groups 1 to 3Sugaya Groups 4 and 5Mean difference (95% CI)p value
WORC in points98 $ \pm $ 297 $ ,"[99.0, 165.0, 1070.0, 252.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 12,6,vision_footnote,Data are presented as the mean ± SD. SSP = supraspinatus tendon; WORC = Western Ontario Rotator Cuff Index.,"[98.0, 262.0, 956.0, 285.0]",footnote,0.7,"[""vision_footnote label: Data are presented as the mean \u00b1 SD. SSP = supraspinatus ten""]",footnote,0.7,body_zone,body_like,none,True,True 12,7,paragraph_title,Clinical Outcome Depending on Retear of the SSP,"[98.0, 321.0, 513.0, 345.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical Outcome Depending on Retear of the SSP""]",subsection_heading,0.6,body_zone,heading_like,none,True,True -12,8,text,We found no difference in clinical outcome between patients with intact and reruptured SSP tendons and no association with preoperative glenoid morphology and orientation. These results are important ,"[95.0, 368.0, 571.0, 968.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +12,8,text,We found no difference in clinical outcome between patients with intact and reruptured SSP tendons and no association with preoperative glenoid morphology and orientation. These results are important ,"[95.0, 368.0, 571.0, 968.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 12,9,paragraph_title,Conclusion,"[100.0, 1015.0, 198.0, 1037.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True -12,10,text,"We found that acromiohumeral distance and acromial slope are associated with the risk of retear of the SSP tendon after repair. In addition, we observed no association of glenoid inclination and gleno","[97.0, 1061.0, 571.0, 1424.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,11,text,,"[599.0, 321.0, 1069.0, 370.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +12,10,text,"We found that acromiohumeral distance and acromial slope are associated with the risk of retear of the SSP tendon after repair. In addition, we observed no association of glenoid inclination and gleno","[97.0, 1061.0, 571.0, 1424.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,11,text,"studies might investigate whether more-radical acromioplasty +can reduce the risk of rerupture of the SSP in these patients.","[599.0, 321.0, 1069.0, 370.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,12,paragraph_title,References,"[602.0, 392.0, 708.0, 415.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True 12,13,reference_content,"1. Ames JB, Horan MP, Van der Meijden OAJ, Leake MJ, Millett PJ. Association between acromial index and outcomes following arthroscopic repair of full-thickness rotator cuff tears. J Bone Joint Surg A","[611.0, 425.0, 1071.0, 504.0]",reference_item,0.85,"[""reference content label: 1. Ames JB, Horan MP, Van der Meijden OAJ, Leake MJ, Millett""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 12,14,reference_content,"2. Balke M, Schmidt C, Dedy N, Banerjee M, Bouillon B, Liem D. Correlation of acromial morphology with impingement syndrome and rotator cuff tears. Acta Orthop. 2013;84:178-183.","[612.0, 505.0, 1069.0, 564.0]",reference_item,0.85,"[""reference content label: 2. Balke M, Schmidt C, Dedy N, Banerjee M, Bouillon B, Liem ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True @@ -237,7 +259,7 @@ wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[ 12,28,footer_image,,"[904.0, 1471.0, 1071.0, 1502.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,tail_nonref_hold_zone,unknown_like,empty,False,True 12,29,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1.0, 1539.0, 1149.0, 1565.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,support_like,none,False,False 13,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCy -wCX1AWnYQp/llQrhD3i3D0OdRyj7TvSFI4Ci3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[20.0, 268.0, 54.0, 931.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +wCX1AWnYQp/llQrhD3i3D0OdRyj7TvSFI4Ci3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[20.0, 268.0, 54.0, 931.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 13,1,number,1170,"[102.0, 81.0, 142.0, 100.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False 13,2,header,Caffard et al.,"[172.0, 81.0, 270.0, 101.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False 13,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[738.0, 81.0, 1069.0, 101.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False diff --git a/audit/A8E7SRVS/changed_blocks_after_fallback.json b/audit/A8E7SRVS/changed_blocks_after_fallback.json index 78967283..4c438fc2 100644 --- a/audit/A8E7SRVS/changed_blocks_after_fallback.json +++ b/audit/A8E7SRVS/changed_blocks_after_fallback.json @@ -232,7 +232,7 @@ { "block_id": "p5:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -250,7 +250,7 @@ { "block_id": "p5:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -268,7 +268,7 @@ { "block_id": "p5:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -286,7 +286,7 @@ { "block_id": "p5:10", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -322,7 +322,7 @@ { "block_id": "p6:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, diff --git a/audit/A8E7SRVS/coverage_check.json b/audit/A8E7SRVS/coverage_check.json index 6c0f752f..060be9d1 100644 --- a/audit/A8E7SRVS/coverage_check.json +++ b/audit/A8E7SRVS/coverage_check.json @@ -2,23 +2,13 @@ "paper_key": "A8E7SRVS", "mode": "high-risk", "required_block_ids": [ - "p10:0", - "p10:12", "p10:13", "p10:15", - "p10:4", "p10:5", - "p10:9", - "p11:0", - "p11:10", - "p11:11", "p11:12", "p11:14", - "p11:4", "p11:5", - "p12:0", "p12:10", - "p12:11", "p12:12", "p12:13", "p12:14", @@ -37,7 +27,6 @@ "p12:27", "p12:28", "p12:29", - "p12:4", "p12:5", "p12:8", "p12:9", @@ -60,42 +49,21 @@ "p1:7", "p1:8", "p1:9", - "p4:0", - "p4:11", "p4:18", - "p4:4", "p4:5", - "p5:0", "p5:10", - "p5:11", "p5:12", "p5:4", - "p5:5", "p5:6", - "p5:7", "p5:8", - "p5:9", - "p6:0", - "p6:12", "p6:13", "p6:20", "p6:4", - "p6:5", - "p6:9", - "p7:0", - "p7:11", "p7:16", - "p7:4", "p7:5", - "p8:0", - "p8:11", "p8:18", - "p8:8", "p8:9", - "p9:0", - "p9:10", "p9:13", - "p9:4", "p9:5", "p9:9" ], diff --git a/audit/A8E7SRVS/fulltext_block_mapping_summary.json b/audit/A8E7SRVS/fulltext_block_mapping_summary.json index cfbd3b05..70be9226 100644 --- a/audit/A8E7SRVS/fulltext_block_mapping_summary.json +++ b/audit/A8E7SRVS/fulltext_block_mapping_summary.json @@ -1,12 +1,12 @@ { - "mappable_block_count": 210, - "found_count": 124, - "missing_count": 86, + "mappable_block_count": 215, + "found_count": 88, + "missing_count": 127, "rows": [ { "block_id": "p1:0", "page": 1, - "role": "unknown_structural", + "role": "noise", "zone": "frontmatter_main_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -56,9 +56,9 @@ { "block_id": "p1:5", "page": 1, - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", - "render_default": false, + "render_default": true, "snippet": "Thomas Caffard Dr med¹, Desdemona Kralewski Dr med¹, Marius Ludwig Dr med¹, Dani", "found_in_fulltext": false, "fulltext_offset": -1 @@ -71,7 +71,7 @@ "render_default": true, "snippet": "Questions/purposes (1) Is acromial morphology associated with the risk of retear", "found_in_fulltext": true, - "fulltext_offset": 6458 + "fulltext_offset": 7425 }, { "block_id": "p1:12", @@ -90,8 +90,8 @@ "zone": "body_zone", "render_default": true, "snippet": "All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and R", - "found_in_fulltext": true, - "fulltext_offset": 6747 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p1:14", @@ -121,7 +121,7 @@ "render_default": true, "snippet": "M. Sgroi ✉, Oberer Eelsberg 45, DE-89081 Ulm, Germany, Email: sgroi.mirco@yahoo.", "found_in_fulltext": true, - "fulltext_offset": 7422 + "fulltext_offset": 7792 }, { "block_id": "p1:18", @@ -136,7 +136,7 @@ { "block_id": "p2:0", "page": 2, - "role": "non_body_insert", + "role": "noise", "zone": "frontmatter_side_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -203,6 +203,16 @@ "found_in_fulltext": true, "fulltext_offset": 5435 }, + { + "block_id": "p2:7", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "rerupture after repair. Conversely, the critical shoulder angle, acromial tilt, ", + "found_in_fulltext": true, + "fulltext_offset": 6442 + }, { "block_id": "p2:9", "page": 2, @@ -210,8 +220,8 @@ "zone": "frontmatter_side_zone", "render_default": true, "snippet": "Introduction", - "found_in_fulltext": true, - "fulltext_offset": 7524 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p2:10", @@ -221,7 +231,7 @@ "render_default": true, "snippet": "Despite great scientific interest, the pathogenesis of supraspinatus (SSP) rerup", "found_in_fulltext": true, - "fulltext_offset": 7537 + "fulltext_offset": 7891 }, { "block_id": "p2:12", @@ -236,7 +246,7 @@ { "block_id": "p3:0", "page": 3, - "role": "non_body_insert", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -280,8 +290,8 @@ "zone": "body_zone", "render_default": true, "snippet": "been established between the acromion and glenoid morphology and clinical result", - "found_in_fulltext": true, - "fulltext_offset": 9344 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:5", @@ -290,8 +300,8 @@ "zone": "body_zone", "render_default": true, "snippet": "We therefore asked: (1) Is acromial morphology associated with the risk of retea", - "found_in_fulltext": true, - "fulltext_offset": 9572 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:6", @@ -301,7 +311,7 @@ "render_default": true, "snippet": "Patients and Methods Study Design and Setting", "found_in_fulltext": true, - "fulltext_offset": 9930 + "fulltext_offset": 9702 }, { "block_id": "p3:8", @@ -310,8 +320,8 @@ "zone": "body_zone", "render_default": true, "snippet": "This retrospective study investigated the relationship of acromial morphology an", - "found_in_fulltext": true, - "fulltext_offset": 9976 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:9", @@ -320,8 +330,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Participants", - "found_in_fulltext": true, - "fulltext_offset": 10293 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:10", @@ -340,8 +350,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Descriptive Data", - "found_in_fulltext": true, - "fulltext_offset": 11182 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:12", @@ -360,8 +370,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Surgical Technique", - "found_in_fulltext": true, - "fulltext_offset": 11548 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:14", @@ -371,7 +381,7 @@ "render_default": true, "snippet": "Two experienced shoulder surgeons (TK and MS), who were not involved in the radi", "found_in_fulltext": true, - "fulltext_offset": 11567 + "fulltext_offset": 10620 }, { "block_id": "p3:15", @@ -381,7 +391,7 @@ "render_default": true, "snippet": "Aftercare", "found_in_fulltext": true, - "fulltext_offset": 13970 + "fulltext_offset": 13023 }, { "block_id": "p3:16", @@ -391,7 +401,7 @@ "render_default": true, "snippet": "After the surgical procedure, the operated-on arm was immobilized in an abductio", "found_in_fulltext": true, - "fulltext_offset": 13980 + "fulltext_offset": 13033 }, { "block_id": "p3:18", @@ -406,7 +416,7 @@ { "block_id": "p4:0", "page": 4, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -444,12 +454,12 @@ "fulltext_offset": -1 }, { - "block_id": "p4:5", + "block_id": "p4:4", "page": 4, - "role": "media_asset", - "zone": "body_zone", + "role": "table_caption", + "zone": "display_zone", "render_default": true, - "snippet": "
ParameterValue
Women, % (n)51 ", + "snippet": "Table 1. Demographic data and preoperative tendon quality of the investigated pa", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -461,7 +471,7 @@ "render_default": true, "snippet": "Interval-scaled variables were tested with a t-test. ASA = American Society of A", "found_in_fulltext": true, - "fulltext_offset": 14326 + "fulltext_offset": 13379 }, { "block_id": "p4:7", @@ -471,7 +481,7 @@ "render_default": true, "snippet": "Clinical Assessment at Follow-up", "found_in_fulltext": true, - "fulltext_offset": 14428 + "fulltext_offset": 13481 }, { "block_id": "p4:8", @@ -480,8 +490,8 @@ "zone": "body_zone", "render_default": true, "snippet": "All patients were clinically assessed at a minimum follow-up of 2 years by a sin", - "found_in_fulltext": true, - "fulltext_offset": 14461 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:9", @@ -490,8 +500,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Radiologic Examination at Follow-up", - "found_in_fulltext": true, - "fulltext_offset": 14728 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:10", @@ -503,6 +513,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p4:11", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "body. A dedicated standard shoulder coil was placed over the shoulder. Two blind", + "found_in_fulltext": true, + "fulltext_offset": 13740 + }, { "block_id": "p4:12", "page": 4, @@ -510,8 +530,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Measurements on Preoperative True AP Radiographs and MRI", - "found_in_fulltext": true, - "fulltext_offset": 16067 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:13", @@ -520,8 +540,8 @@ "zone": "body_zone", "render_default": true, "snippet": "As part of the preoperative plan, MRI was preoperatively performed on all should", - "found_in_fulltext": true, - "fulltext_offset": 16124 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:14", @@ -531,7 +551,7 @@ "render_default": true, "snippet": "Acromiohumeral Interval", "found_in_fulltext": true, - "fulltext_offset": 16603 + "fulltext_offset": 14817 }, { "block_id": "p4:15", @@ -541,7 +561,7 @@ "render_default": true, "snippet": "The acromiohumeral interval was defined as the shortest interval between the hum", "found_in_fulltext": true, - "fulltext_offset": 16627 + "fulltext_offset": 14841 }, { "block_id": "p4:16", @@ -551,7 +571,7 @@ "render_default": true, "snippet": "Glenoidal Version", "found_in_fulltext": true, - "fulltext_offset": 17055 + "fulltext_offset": 15269 }, { "block_id": "p4:17", @@ -561,7 +581,7 @@ "render_default": true, "snippet": "Glenoid version was measured in the axial plane according to Friedman et al. [11", "found_in_fulltext": true, - "fulltext_offset": 17073 + "fulltext_offset": 15287 }, { "block_id": "p4:19", @@ -576,7 +596,7 @@ { "block_id": "p5:0", "page": 5, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -613,46 +633,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p5:5", - "page": 5, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 1 This figure shows how the critical shoulder angle (CSA) was determined. T", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, - { - "block_id": "p5:7", - "page": 5, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 3 The figure shows how acromial tilt (AT) was determined. Acromial tilt was", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, - { - "block_id": "p5:9", - "page": 5, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 2 The figure shows the measurement of acromial slope (AS). To measure acrom", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, - { - "block_id": "p5:11", - "page": 5, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 4 The figure shows how the lateral acromial angle (LAA) was determined. Fir", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p5:13", "page": 5, @@ -666,7 +646,7 @@ { "block_id": "p6:0", "page": 6, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -703,16 +683,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p6:5", - "page": 6, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 5 The figure shows how the acromial index was determined. A line was drawn ", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p6:6", "page": 6, @@ -721,7 +691,7 @@ "render_default": true, "snippet": "The angle between these two lines was defined as the glenoid version.", "found_in_fulltext": true, - "fulltext_offset": 17558 + "fulltext_offset": 15772 }, { "block_id": "p6:7", @@ -731,7 +701,7 @@ "render_default": true, "snippet": "Glenoidal Inclination", "found_in_fulltext": true, - "fulltext_offset": 17632 + "fulltext_offset": 15846 }, { "block_id": "p6:8", @@ -740,8 +710,18 @@ "zone": "body_zone", "render_default": true, "snippet": "Glenoid inclination was measured in the coronal plane using MRI according to Hug", - "found_in_fulltext": true, - "fulltext_offset": 17654 + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:9", + "page": 6, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 2. Sugaya classification [10, 38]", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p6:10", @@ -751,7 +731,7 @@ "render_default": true, "snippet": "Measurements on Postoperative MRI", "found_in_fulltext": true, - "fulltext_offset": 17960 + "fulltext_offset": 15872 }, { "block_id": "p6:11", @@ -760,16 +740,16 @@ "zone": "body_zone", "render_default": true, "snippet": "To investigate the quality and morphologic integrity of the SSP tendon, the foll", - "found_in_fulltext": true, - "fulltext_offset": 17994 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { - "block_id": "p6:13", + "block_id": "p6:12", "page": 6, - "role": "media_asset", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, - "snippet": "
Type 1Sufficient thickness of the tendon, tendon continu", + "snippet": "38]; SSP tendon integrity according to Castricini et al. [5], including signal i", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -781,7 +761,7 @@ "render_default": true, "snippet": "Sugaya Classification", "found_in_fulltext": true, - "fulltext_offset": 18503 + "fulltext_offset": 15910 }, { "block_id": "p6:15", @@ -791,7 +771,7 @@ "render_default": true, "snippet": "To assess the tendon’s integrity, we applied the Sugaya classification (Table 2)", "found_in_fulltext": true, - "fulltext_offset": 18525 + "fulltext_offset": 15932 }, { "block_id": "p6:16", @@ -801,7 +781,7 @@ "render_default": true, "snippet": "Castricini Classification", "found_in_fulltext": true, - "fulltext_offset": 19085 + "fulltext_offset": 16492 }, { "block_id": "p6:17", @@ -811,7 +791,7 @@ "render_default": true, "snippet": "To better investigate tendon quality after repair, we applied the Castricini cla", "found_in_fulltext": true, - "fulltext_offset": 19111 + "fulltext_offset": 16518 }, { "block_id": "p6:18", @@ -821,7 +801,7 @@ "render_default": true, "snippet": "Fatty Infiltration of the SSP Muscle", "found_in_fulltext": true, - "fulltext_offset": 19534 + "fulltext_offset": 16941 }, { "block_id": "p6:19", @@ -831,7 +811,7 @@ "render_default": true, "snippet": "We evaluated fatty infiltration according to Goutailler et al. [14]. A study on ", "found_in_fulltext": true, - "fulltext_offset": 19571 + "fulltext_offset": 16978 }, { "block_id": "p6:21", @@ -846,7 +826,7 @@ { "block_id": "p7:0", "page": 7, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -884,12 +864,12 @@ "fulltext_offset": -1 }, { - "block_id": "p7:5", + "block_id": "p7:4", "page": 7, - "role": "media_asset", - "zone": "body_zone", + "role": "table_caption", + "zone": "display_zone", "render_default": true, - "snippet": "
Signal intensityIHigher signal intensity throug", + "snippet": "Table 3. Castricini classification [5]", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -901,7 +881,7 @@ "render_default": true, "snippet": "with the Goutailler classification found good intrarater (ICC = 0.72) and interr", "found_in_fulltext": true, - "fulltext_offset": 19781 + "fulltext_offset": 17188 }, { "block_id": "p7:7", @@ -911,7 +891,7 @@ "render_default": true, "snippet": "Atrophy of the SSP Muscle", "found_in_fulltext": true, - "fulltext_offset": 19901 + "fulltext_offset": 17308 }, { "block_id": "p7:8", @@ -920,8 +900,8 @@ "zone": "body_zone", "render_default": true, "snippet": "We graded SSP muscle atrophy according to Thomazeau et al.'s method [36]. A stud", - "found_in_fulltext": true, - "fulltext_offset": 19927 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p7:9", @@ -930,8 +910,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Primary and Secondary Study Outcomes", - "found_in_fulltext": true, - "fulltext_offset": 20176 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p7:10", @@ -941,7 +921,17 @@ "render_default": true, "snippet": "Our primary study goal was to investigate the association between acromion morph", "found_in_fulltext": true, - "fulltext_offset": 20213 + "fulltext_offset": 17334 + }, + { + "block_id": "p7:11", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "with patients with an intact SSP. To answer our third re- search question, there", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p7:12", @@ -950,8 +940,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Ethical Approval", - "found_in_fulltext": true, - "fulltext_offset": 21761 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p7:13", @@ -960,8 +950,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Independent institutional review board approval was obtained from the ethics com", - "found_in_fulltext": true, - "fulltext_offset": 7215 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p7:14", @@ -971,7 +961,7 @@ "render_default": true, "snippet": "Statistical Analysis", "found_in_fulltext": true, - "fulltext_offset": 21911 + "fulltext_offset": 18882 }, { "block_id": "p7:15", @@ -981,7 +971,7 @@ "render_default": true, "snippet": "The sample size was calculated based on a binomial logarithmic regression analys", "found_in_fulltext": true, - "fulltext_offset": 21932 + "fulltext_offset": 18903 }, { "block_id": "p7:17", @@ -996,7 +986,7 @@ { "block_id": "p8:0", "page": 8, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -1040,8 +1030,8 @@ "zone": "body_zone", "render_default": true, "snippet": "according to the Sugaya classification (Group 1: Sugaya Grades 1 to 3 and Group ", - "found_in_fulltext": true, - "fulltext_offset": 23312 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:5", @@ -1050,8 +1040,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Results Acromial Morphology and Retear Risk", - "found_in_fulltext": true, - "fulltext_offset": 23836 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:7", @@ -1061,15 +1051,15 @@ "render_default": true, "snippet": "Only the acromiohumeral interval (adjusted OR 0.9 [95% CI 0.9 to 0.99; p < 0.01)", "found_in_fulltext": true, - "fulltext_offset": 23880 + "fulltext_offset": 20283 }, { - "block_id": "p8:9", + "block_id": "p8:8", "page": 8, - "role": "media_asset", - "zone": "body_zone", + "role": "table_caption", + "zone": "display_zone", "render_default": true, - "snippet": "
VariableAdjusted OR (95% CI)p value
VariableSugaya 1 to 3Sugaya 4 and 5Mea", + "snippet": "Table 5. Comparison between patients with an intact SSP and those with a reruptu", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -1211,7 +1211,7 @@ "render_default": true, "snippet": "Data are presented as the mean ± SD. SSP = supraspinatus tendon; AHI = acromiohu", "found_in_fulltext": true, - "fulltext_offset": 27745 + "fulltext_offset": 23695 }, { "block_id": "p9:7", @@ -1221,7 +1221,7 @@ "render_default": true, "snippet": "Limitations", "found_in_fulltext": true, - "fulltext_offset": 27969 + "fulltext_offset": 23919 }, { "block_id": "p9:8", @@ -1230,16 +1230,6 @@ "zone": "body_zone", "render_default": true, "snippet": "First, in most instances, the analyzed patients underwent mild acromioplasty. Be", - "found_in_fulltext": true, - "fulltext_offset": 27981 - }, - { - "block_id": "p9:10", - "page": 9, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 6 The figure represents the receiver operating characteristic curve of the ", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -1250,8 +1240,8 @@ "zone": "body_zone", "render_default": true, "snippet": "technique were included. In our opinion, this criterion was important because if", - "found_in_fulltext": true, - "fulltext_offset": 28708 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p9:12", @@ -1260,8 +1250,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Fourth, because the preoperative MRI examinations were performed before the star", - "found_in_fulltext": true, - "fulltext_offset": 29928 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p9:14", @@ -1276,7 +1266,7 @@ { "block_id": "p10:0", "page": 10, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -1313,6 +1303,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p10:4", + "page": 10, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 6. Sensitivity, specificity, likelihood ratio, OR, and AUC of acromial slo", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p10:5", "page": 10, @@ -1331,7 +1331,7 @@ "render_default": true, "snippet": "AUC = area under the curve.", "found_in_fulltext": true, - "fulltext_offset": 30974 + "fulltext_offset": 24014 }, { "block_id": "p10:7", @@ -1341,7 +1341,7 @@ "render_default": true, "snippet": "resolution. However, we do not have a 3.0 Tesla MRI in our department; this refl", "found_in_fulltext": true, - "fulltext_offset": 31002 + "fulltext_offset": 24042 }, { "block_id": "p10:8", @@ -1350,8 +1350,18 @@ "zone": "body_zone", "render_default": true, "snippet": "Sixth, residents performed the measurements. Because of their inexperience, they", - "found_in_fulltext": true, - "fulltext_offset": 31171 + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:9", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "have biased the assessment of the influence of acromial morphology and glenoid or", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p10:10", @@ -1361,7 +1371,7 @@ "render_default": true, "snippet": "Acromial Morphology and Retear Risk", "found_in_fulltext": true, - "fulltext_offset": 23844 + "fulltext_offset": 24215 }, { "block_id": "p10:11", @@ -1370,8 +1380,18 @@ "zone": "body_zone", "render_default": true, "snippet": "We found that of the acromial morphologic measures analyzed, only acromial slope", - "found_in_fulltext": true, - "fulltext_offset": 33393 + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:12", + "page": 10, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 7. Clinical and radiologic outcomes depending on the AHI cutoff", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p10:13", @@ -1391,7 +1411,7 @@ "render_default": true, "snippet": "AHI = acromiohumeral interval; WORC = Western Ontario Rotator Cuff Index.", "found_in_fulltext": true, - "fulltext_offset": 34364 + "fulltext_offset": 24251 }, { "block_id": "p10:16", @@ -1406,7 +1426,7 @@ { "block_id": "p11:0", "page": 11, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -1443,6 +1463,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p11:4", + "page": 11, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 8. Clinical and radiologic outcomes depending on the AS cutoff", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p11:5", "page": 11, @@ -1461,7 +1491,7 @@ "render_default": true, "snippet": "AS = acromial slope; WORC = Western Ontario Rotator Cuff Index,", "found_in_fulltext": true, - "fulltext_offset": 34455 + "fulltext_offset": 24342 }, { "block_id": "p11:7", @@ -1471,7 +1501,7 @@ "render_default": true, "snippet": "that a higher critical shoulder angle is associated with a higher risk of full-t", "found_in_fulltext": true, - "fulltext_offset": 34519 + "fulltext_offset": 24406 }, { "block_id": "p11:8", @@ -1480,8 +1510,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Glenoid Morphology and Retear Risk", - "found_in_fulltext": true, - "fulltext_offset": 26111 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p11:9", @@ -1490,16 +1520,26 @@ "zone": "body_zone", "render_default": true, "snippet": "We found that glenoid orientation in terms of inclination and version was not as", - "found_in_fulltext": true, - "fulltext_offset": 35837 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { - "block_id": "p11:12", + "block_id": "p11:10", "page": 11, - "role": "media_asset", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, - "snippet": "
VariableSugaya Groups 1 to 3Sugaya Groups 4 and", + "snippet": "according to our results, surgeons do not need to measure glenoid morphology pre", + "found_in_fulltext": true, + "fulltext_offset": 25685 + }, + { + "block_id": "p11:11", + "page": 11, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 9. Comparison between patients with an intact SSP and those with a reruptu", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -1510,8 +1550,8 @@ "zone": "body_zone", "render_default": true, "snippet": "SSP = supraspinatus tendon; GV = glenoidal version; GI = glenoidal inclination.", - "found_in_fulltext": true, - "fulltext_offset": 37825 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p11:15", @@ -1526,7 +1566,7 @@ { "block_id": "p12:0", "page": 12, - "role": "unknown_structural", + "role": "noise", "zone": "", "render_default": false, "snippet": "Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+", @@ -1564,12 +1604,12 @@ "fulltext_offset": -1 }, { - "block_id": "p12:5", + "block_id": "p12:4", "page": 12, - "role": "media_asset", - "zone": "body_zone", + "role": "table_caption", + "zone": "display_zone", "render_default": true, - "snippet": "
VariableSugaya Groups 1 to 3Sugaya Groups 4 and", + "snippet": "Table 10. Postoperative clinical outcomes depending on SSP integrity", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -1581,7 +1621,7 @@ "render_default": true, "snippet": "Data are presented as the mean ± SD. SSP = supraspinatus tendon; WORC = Western ", "found_in_fulltext": true, - "fulltext_offset": 37954 + "fulltext_offset": 27496 }, { "block_id": "p12:7", @@ -1591,7 +1631,7 @@ "render_default": true, "snippet": "Clinical Outcome Depending on Retear of the SSP", "found_in_fulltext": true, - "fulltext_offset": 38066 + "fulltext_offset": 27608 }, { "block_id": "p12:8", @@ -1600,8 +1640,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "We found no difference in clinical outcome between patients with intact and reru", - "found_in_fulltext": true, - "fulltext_offset": 38114 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p12:9", @@ -1621,7 +1661,17 @@ "render_default": true, "snippet": "We found that acromiohumeral distance and acromial slope are associated with the", "found_in_fulltext": true, - "fulltext_offset": 39527 + "fulltext_offset": 27656 + }, + { + "block_id": "p12:11", + "page": 12, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "studies might investigate whether more-radical acromioplasty can reduce the risk", + "found_in_fulltext": true, + "fulltext_offset": 28567 }, { "block_id": "p12:12", @@ -1630,8 +1680,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "References", - "found_in_fulltext": true, - "fulltext_offset": 40597 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p12:13", @@ -1640,8 +1690,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "1. Ames JB, Horan MP, Van der Meijden OAJ, Leake MJ, Millett PJ. Association bet", - "found_in_fulltext": true, - "fulltext_offset": 40608 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p12:14", @@ -1651,7 +1701,7 @@ "render_default": true, "snippet": "2. Balke M, Schmidt C, Dedy N, Banerjee M, Bouillon B, Liem D. Correlation of ac", "found_in_fulltext": true, - "fulltext_offset": 40830 + "fulltext_offset": 28691 }, { "block_id": "p12:15", @@ -1661,7 +1711,7 @@ "render_default": true, "snippet": "3. Bigliani LU, Ticker JB, Flatow EL, Soslotsky LJ, Mow VC. The relationship of ", "found_in_fulltext": true, - "fulltext_offset": 41008 + "fulltext_offset": 28869 }, { "block_id": "p12:16", @@ -1671,7 +1721,7 @@ "render_default": true, "snippet": "4. Bishop JL, Kline SK, Aalderink KJ, Zauel R, Bey MJ. 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"logical_order_between_reference_members" }, diff --git a/audit/A8E7SRVS/reference_span_audit.json b/audit/A8E7SRVS/reference_span_audit.json index 662182e7..d357c0b8 100644 --- a/audit/A8E7SRVS/reference_span_audit.json +++ b/audit/A8E7SRVS/reference_span_audit.json @@ -32,7 +32,6 @@ "p12:25", "p12:26", "p12:27", - "p13:0", "p13:4", "p13:5", "p13:6", @@ -76,7 +75,6 @@ "p12:25", "p12:26", "p12:27", - "p13:0", "p13:4", "p13:5", "p13:6", @@ -230,7 +228,7 @@ { "block_id": "p13:0", "page": 13, - "role": "unknown_structural", + "role": "noise", "zone": "", "reason": "logical_order_between_reference_members" }, diff --git a/audit/CAQNW9Q2/audit_report.json b/audit/CAQNW9Q2/audit_report.json index 8211de8e..5d7d91a2 100644 --- a/audit/CAQNW9Q2/audit_report.json +++ b/audit/CAQNW9Q2/audit_report.json @@ -5,23 +5,23 @@ "focus": [], "artifact_fingerprint": { "result_json_hash": "sha256:fd3debcf56475c87f9bf218139d255d6ed5a9d82f629776d7c3d3798b13a872e", - "meta_json_hash": "sha256:b47fe1cc4a350b3bf975621b837aaa5b608b9f20edbe6e8a1d5fcd6c20657dc5", - "blocks_raw_hash": "sha256:c66058b66b83b98802202df8894f1e068f08b55ad0f75fb4a3d13754bbf7573e", - "structured_blocks_hash": "sha256:8c413ef65faef87abbff3fbd4ba264959a28ccdc3786984ca02e6b2178d50ddf", - "document_structure_hash": "sha256:c825e23daf16640868aabb56f62e880d624ae133ed90432ece8058720c000f98", - "figure_inventory_hash": "sha256:9d4ea87265b6ca0db222792e29e78ed01a77de2f1da9004e37ff889b0e503f72", + "meta_json_hash": "sha256:8701497ee57b454e14e8fd3c601c5998068e447c7accd666c3fe8f2c28ad4854", + "blocks_raw_hash": "sha256:a65da01391fd0eb3b06ed96167039b9e31686f736529140686067f25faccd1cf", + "structured_blocks_hash": "sha256:68fdbb6b7098bf6cb2d1c664fded859062709de9867a2f50ae79cd6a684fb822", + "document_structure_hash": "sha256:5b627c7c64bc41f4d8697cd2e7c4de112712828570611ac83c7849b6f771d6d0", + "figure_inventory_hash": "sha256:a4a042bb385609c314170c7ea2a719369ce492f580631c4066423678080021f8", "table_inventory_hash": "sha256:86ccb48fbfd41da91e87ea2c1ef938513732868efcb5e30b31c36f96d432bba2", - "reader_figures_hash": "sha256:98c1b4cce1b81b44f65a884c35a019cf40e3c3ef36ba0b8bb56752bdd2389f03", + "reader_figures_hash": "sha256:c7c08aa65b3913acf6e94800e74a07d508c9e992138913689b168caa5f645e6e", "resolved_metadata_hash": "sha256:0be08ce2a0c98dcb2f021764f266a52237ac00877c42da21d6d81f871772f9bf", - "fulltext_hash": "sha256:0f26935f958e71edeb1dcdc57d465a2eb1b6e0097510ff2e3e653988f0341f40", - "block_trace_hash": "sha256:ac0cb0584d551885e1b5cab09ba4faaf0d49c33dd9fd52963100edb9381d6840", + "fulltext_hash": "sha256:827d33526f9d88bc57f6869fee340548b6d3fcdeff4923bedae23024d5a7adbf", + "block_trace_hash": "sha256:48c53009f7dfab5efaa999fb325f6916b9f8825ba296a47e7cd97fa67ceddc1f", "annotated_pages": { - "page_001.png": "sha256:91b8bc2783635b512fdf002b86ef5b66ed89087033f43b7996fd812d08b77d9e", - "page_002.png": "sha256:fec51def180c3266c0f8b1d182b08d59c516f54f28b1970ec63178cfc4888dc7", - "page_003.png": "sha256:0429e88f78f85c7e8605722275a19657d9d6c519c8fe5cfbf1324fe4562900ae", - "page_004.png": "sha256:0cd1df6f524f2249aff4ea78bd0b1c6eeb3c00ff39a724cb564cb15ff1e8dc07", - "page_005.png": "sha256:d98d9f4831d45f62957e428c99136ec4f8b7c9ca908fd12e93994d6b47d6ccd8", - "page_006.png": "sha256:8185173a20dcd9185ba20ef33ad5f15e3d90d1e7daaf7055de37dada5e667112", + "page_001.png": "sha256:eb93ac63c293ab99ef98fb32bdb8bfd8ac11b0f808f72db6aa7d0c84b0a6ae2b", + "page_002.png": "sha256:1f908a14853ea91efa280ee10627a1ab1f4370f2c1a621e7f1b67cd87a7aa01e", + "page_003.png": "sha256:cefd9236798748d6340ad7070f81eac4c51549f5ee4b25bed66f6ca171d6d2d8", + "page_004.png": "sha256:73f320778bb2ce081699ab526899b5beddd58433e67b1b17e35c0230c798a942", + "page_005.png": "sha256:1660b9c26d8abd8e34b4c577da094757f4066c93c80f8830a08842586a9a038b", + "page_006.png": "sha256:5d6edea34c1e1a739d6ebb3248ea611efdfdd26362868a8961bf2395195d2708", "page_007.png": "sha256:420c6905950f9649e29782223f9477e7ef6a67a3c4e4567279d66ef001fbab65", "page_008.png": "sha256:6002671da8eeec3249e211ba9e9ac3ae7be07f9a62e21d06c0aeff75723e9dce" } @@ -29,7 +29,10 @@ "artifact_freshness": { "missing": [], "mismatches": [ - "document_structure older than blocks_structured" + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" ], "annotated_pages_rendered": [ "page_001.png", @@ -155,286 +158,6 @@ "p7:51" ], "findings": [ - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:6" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:7" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:8" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:9" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:10" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:11" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:12" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:13" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:14" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:15" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:16" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:17" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:18" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:19" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:20" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:21" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:22" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:23" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:24" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p7:25" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_007.png", - "artifact": "reference_span_audit.json" - } - }, { "category": "same_page_boundary_error", "severity": "major", @@ -457,13 +180,10 @@ "p1:8", "p2:0", "p2:1", - "p2:3", "p3:0", "p4:0", "p4:1", - "p4:4", "p5:9", - "p5:11", "p6:0", "p6:1", "p6:3", diff --git a/audit/CAQNW9Q2/audit_report.md b/audit/CAQNW9Q2/audit_report.md index fa899322..29bbfbc8 100644 --- a/audit/CAQNW9Q2/audit_report.md +++ b/audit/CAQNW9Q2/audit_report.md @@ -7,26 +7,6 @@ ## Findings -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output diff --git a/audit/CAQNW9Q2/audit_scope.json b/audit/CAQNW9Q2/audit_scope.json index 0a9bb088..3b7c303c 100644 --- a/audit/CAQNW9Q2/audit_scope.json +++ b/audit/CAQNW9Q2/audit_scope.json @@ -25,19 +25,12 @@ "p1:14", "p1:15", "p2:2", - "p2:3", "p2:5", "p4:2", "p4:3", - "p4:4", - "p4:10", "p5:6", - "p5:7", "p5:9", "p5:10", - "p5:11", - "p7:4", - "p7:5", "p7:6", "p7:7", "p7:8", @@ -240,8 +233,7 @@ "block_id": "p1:10", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -342,21 +334,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p2:3", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p2:5", "page": 2, @@ -402,36 +379,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p4:4", - "page": 4, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:10", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:6", "page": 5, @@ -447,21 +394,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:7", - "page": 5, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:9", "page": 5, @@ -492,51 +424,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:11", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:4", - "page": 7, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:5", - "page": 7, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:6", "page": 7, @@ -1237,22 +1124,22 @@ { "page": 2, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 2 }, { "page": 4, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 2 }, { "page": 5, "must_review_page": true, - "required_block_count": 5 + "required_block_count": 3 }, { "page": 7, "must_review_page": true, - "required_block_count": 48 + "required_block_count": 46 } ] } \ No newline at end of file diff --git a/audit/CAQNW9Q2/block_coverage_summary.json b/audit/CAQNW9Q2/block_coverage_summary.json index 5d93ca8d..d2a13d64 100644 --- a/audit/CAQNW9Q2/block_coverage_summary.json +++ b/audit/CAQNW9Q2/block_coverage_summary.json @@ -226,7 +226,7 @@ "block_id": "p1:10", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "frontmatter_noise", "zone": "body_zone", "bbox": [ 718.0, @@ -386,7 +386,7 @@ "block_id": "p2:2", "page": 2, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 294.0, @@ -406,7 +406,7 @@ "block_id": "p2:3", "page": 2, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 287.0, @@ -606,7 +606,7 @@ "block_id": "p3:5", "page": 3, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 719.0, @@ -726,7 +726,7 @@ "block_id": "p4:2", "page": 4, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 95.0, @@ -746,7 +746,7 @@ "block_id": "p4:3", "page": 4, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 95.0, @@ -766,7 +766,7 @@ "block_id": "p4:4", "page": 4, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 92.0, @@ -886,7 +886,7 @@ "block_id": "p4:10", "page": 4, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 698.0, @@ -1126,7 +1126,7 @@ "block_id": "p5:7", "page": 5, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 717.0, @@ -1186,7 +1186,7 @@ "block_id": "p5:10", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 324.0, @@ -1206,7 +1206,7 @@ "block_id": "p5:11", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 316.0, @@ -1366,7 +1366,7 @@ "block_id": "p6:7", "page": 6, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 700.0, @@ -1587,7 +1587,7 @@ "page": 7, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 310.0, 235.0, @@ -1607,7 +1607,7 @@ "page": 7, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 312.0, 721.0, diff --git a/audit/CAQNW9Q2/block_review.jsonl b/audit/CAQNW9Q2/block_review.jsonl index 1321709f..11e00317 100644 --- a/audit/CAQNW9Q2/block_review.jsonl +++ b/audit/CAQNW9Q2/block_review.jsonl @@ -14,7 +14,7 @@ {"block_id": "p1:13", "page": 1, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_001.png", "method": "visual+bbox"}, "short_reason": "Body paragraph about advantages, correctly classified.", "_pipeline_verified": true, "_current_role": "body_paragraph"} {"block_id": "p1:14", "page": 1, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_001.png", "method": "visual+bbox"}, "short_reason": "Body paragraph about limitations, correctly classified.", "_pipeline_verified": true, "_current_role": "body_paragraph"} {"block_id": "p1:15", "page": 1, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_001.png", "method": "visual+bbox"}, "short_reason": "Body text about stereotaxic devices and positioning, misclassified as frontmatter_noise.", "_needs_reaudit": true, "_current_role": "frontmatter_noise", "_current_zone": "body_zone"} -{"block_id": "p2:2", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 radiographs, correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:2", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 radiographs, correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p2:3", "page": 2, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 caption, correctly figure_caption_candidate.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p2:5", "page": 2, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Body text about measurement planes and magnification, misclassified as frontmatter_noise in frontmatter_side_zone.", "_pipeline_verified": true, "_current_role": "frontmatter_noise", "_needs_reaudit": true, "_current_zone": "frontmatter_side_zone"} {"block_id": "p4:2", "page": 4, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_004.png", "method": "visual+bbox"}, "short_reason": "Figure 2A macroradiograph, correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} diff --git a/audit/CAQNW9Q2/block_trace.csv b/audit/CAQNW9Q2/block_trace.csv index dc5d3bb2..4124c72e 100644 --- a/audit/CAQNW9Q2/block_trace.csv +++ b/audit/CAQNW9Q2/block_trace.csv @@ -2,7 +2,7 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,0,number,268,"[113.0, 68.0, 146.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False 1,1,header,Annals of the Rheumatic Diseases 1994; 53: 268–275,"[740.0, 66.0, 1108.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,2,paragraph_title,REVIEW,"[112.0, 135.0, 218.0, 162.0]",frontmatter_noise,0.8,"[""page-1 article-type label: review""]",frontmatter_noise,0.8,frontmatter_main_zone,heading_like,short_fragment,False,False -1,3,doc_title,Quantitative radiography of osteoarthritis,"[315.0, 202.0, 963.0, 242.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Quantitative radiography of osteoarthritis""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,3,doc_title,Quantitative radiography of osteoarthritis,"[315.0, 202.0, 963.0, 242.0]",paper_title,0.8,"[""page-1 zone title_zone: Quantitative radiography of osteoarthritis""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True 1,4,text,J C Buckland-Wright,"[312.0, 289.0, 504.0, 315.0]",authors,0.6,"[""page-1 initial-lastname author byline: J C Buckland-Wright""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True 1,5,footer,"Division of Anatomy and Cell Biology, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, United Kingdom J C Buckland-Wright","[112.0, 1346.0, 298.0, 1493.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 1,6,text,"Radiography is important in the diagnosis of osteoarthritis (OA) as the features described in the pathology of the disease can be visualised, with joint space narrowing generally thought to reflect ca","[313.0, 357.0, 706.0, 916.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -16,7 +16,11 @@ London Bridge, London SE1 9RT, United Kingdom.","[114.0, 1496.0, 275.0, 1610.0]",frontmatter_support,0.75,"[""page-1 correspondence footnote: Correspondence to:\nDr J C Buckland-Wright,\nDivision of Anato""]",frontmatter_support,0.75,body_zone,body_like,none,True,True 1,9,text,Quantitative assessments of the structural changes in peripheral joints with OA are based on measurements of distance and area in the radiographic image. Such measurements are obtained either directly,"[314.0, 1382.0, 706.0, 1610.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Quantitative assessments of the structural changes in periph""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False -1,10,text,,"[718.0, 358.0, 1112.0, 662.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +1,10,text,"results of their application in quantifying +disease progression are outlined. Where it has +been possible to obtain precise measurements +of changes in x ray features, this has provided +new insight into","[718.0, 358.0, 1112.0, 662.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: results of their application in quantifying\ndisease progress""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False 1,11,paragraph_title,Standard radiography,"[720.0, 700.0, 932.0, 722.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Standard radiography""]",section_heading,0.5,body_zone,heading_like,none,True,True 1,12,text,"The radiographic image is a shadow of the differential absorption of x rays by the tissues of the joint, where radiographic appearance of bony structures appears white to light grey and the radio-tran","[718.0, 722.0, 1112.0, 851.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,13,text,"Advantages Standard radiography is simple, cheap, easily accessible and well understood. The radiographs provide a permanent record which can be assessed at any stage during the disease process permit","[719.0, 850.0, 1112.0, 1022.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -24,10 +28,10 @@ United Kingdom.","[114.0, 1496.0, 275.0, 1610.0]",frontmatter_support,0.75,"[""p 1,15,text,"Apart from those investigators who have developed special stereotaxic devices for examining leg alignment $ ^{11,12} $ or knee joint motion, $ ^{13} $ there is no accepted method for positioning a joi","[719.0, 1298.0, 1114.0, 1609.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Apart from those investigators who have developed special st""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False 2,0,header,Quantitative radiography of OA,"[88.0, 62.0, 310.0, 84.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False 2,1,number,269,"[1057.0, 61.0, 1089.0, 79.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False -2,2,image,,"[294.0, 111.0, 1087.0, 755.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -2,3,figure_title,"Figure 1 Standard radiographic appearance of osteoarthritic knee joints showing different degrees of joint space narrowing, subchondral sclerosis and osteophytes. The antero-posterior radiographs of t","[287.0, 770.0, 1088.0, 842.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 1 Standard radiographic appearance of osteoarthritic ""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +2,2,image,,"[294.0, 111.0, 1087.0, 755.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +2,3,figure_title,"Figure 1 Standard radiographic appearance of osteoarthritic knee joints showing different degrees of joint space narrowing, subchondral sclerosis and osteophytes. The antero-posterior radiographs of t","[287.0, 770.0, 1088.0, 842.0]",figure_caption,0.92,"[""figure_title label: Figure 1 Standard radiographic appearance of osteoarthritic ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 2,4,text,reliable assessment of joint space loss. The absence of any standards in the radio-anatomical positioning of joints results in variable radiographic images of a joint both within and between patients ,"[288.0, 867.0, 685.0, 1613.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,5,text,"but more often than not the plane of measurement is never defined. Further, no account is taken of the distance between the centre of the joint and the x ray film. Where this is fairly large, as in an","[694.0, 866.0, 1092.0, 1364.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,5,text,"but more often than not the plane of measurement is never defined. Further, no account is taken of the distance between the centre of the joint and the x ray film. Where this is fairly large, as in an","[694.0, 866.0, 1092.0, 1364.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: but more often than not the plane of measurement is never de""]",frontmatter_noise,0.8,frontmatter_side_zone,body_like,none,False,False 2,6,paragraph_title,Quantitative standard radiography,"[697.0, 1402.0, 1027.0, 1423.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Quantitative standard radiography""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 2,7,text,"Quantitative standard radiography has been applied primarily to joint space width (JSW) measurements in OA of the hip and knee, since assessment of articular cartilage thickness is important in evalua","[696.0, 1421.0, 1092.0, 1613.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,0,number,270,"[116.0, 66.0, 149.0, 86.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -35,21 +39,29 @@ United Kingdom.","[114.0, 1496.0, 275.0, 1610.0]",frontmatter_support,0.75,"[""p 3,2,text,"standardisation of the position of the hip and knee and reproducible repositioning of the joints on successive examinations. $ ^{12} $ $ ^{24} $ However, in these studies JSW measurements were carried","[315.0, 124.0, 708.0, 381.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,3,text,"In the former, Martel's group at Michigan University, undertook to define the precision of hyaline cartilage thickness measurements. $ ^{24} $ They used a small sourced x ray tube (0·3 mm focal spot) ","[314.0, 380.0, 708.0, 1237.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,4,text,The development of microcomputers and image analysis technique has provided the means of obtaining an accurate and reproducible method for measuring changes in joint anatomy and for handling large amo,"[313.0, 1237.0, 707.0, 1613.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,5,text,,"[719.0, 126.0, 1116.0, 728.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +3,5,text,"Joint space is assessed automatically using an +edge detection technique and is expressed +either as the mean width of several repeat +measures or as the joint space area. The +reproducibility of the comp","[719.0, 126.0, 1116.0, 728.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,6,paragraph_title,Microfocal radiography,"[722.0, 766.0, 948.0, 789.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Microfocal radiography""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 3,7,text,Microfocal x ray units are characterised by an extremely small x ray source (<15 µm in diameter) which allows radiographs to be taken at high magnification with very fine detail recorded in the film. ,"[720.0, 788.0, 1113.0, 1025.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,8,text,"Advantages of microfocal radiography are those characteristic of an extremely small x ray source. Large object magnifications are obtained ranging from ×2 to ×20, although, macroradiographs are more u","[719.0, 1027.0, 1114.0, 1611.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,0,header,Quantitative radiography of OA,"[91.0, 62.0, 312.0, 85.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 4,1,number,271,"[1059.0, 58.0, 1090.0, 77.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -4,2,image,,"[95.0, 114.0, 677.0, 425.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -4,3,image,,"[95.0, 433.0, 681.0, 736.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -4,4,figure_title,"Figure 2 Part of the macroradiographs of osteoarthritic knee joints with medial compartment involvement, in the weight bearing standing A) and loaded tunnel B) views. In the medial compartment the ant","[92.0, 753.0, 681.0, 840.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 2 Part of the macroradiographs of osteoarthritic knee""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +4,2,image,,"[95.0, 114.0, 677.0, 425.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,3,image,,"[95.0, 433.0, 681.0, 736.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,4,figure_title,"Figure 2 Part of the macroradiographs of osteoarthritic knee joints with medial compartment involvement, in the weight bearing standing A) and loaded tunnel B) views. In the medial compartment the ant","[92.0, 753.0, 681.0, 840.0]",figure_caption,0.92,"[""figure_title label: Figure 2 Part of the macroradiographs of osteoarthritic knee""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 4,5,text,"resolution, makes it possible to detect structural detail virtually at the histological level $ ^{34} $ and to carry out direct accurate measurement of the x ray features characteristic of arthritis w","[295.0, 865.0, 687.0, 973.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,6,text,Limitations are also a function of the small x ray source size. The smallness of the source limits the output of an x ray tube and results in longer exposure times. This restriction has been largely o,"[295.0, 972.0, 688.0, 1122.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,7,text,Care and accuracy are needed in positioning the patient in relation to the source. This requires specially developed apparatus enabling the patient to keep still and to maintain the position of their ,"[295.0, 1121.0, 689.0, 1380.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,8,paragraph_title,Standardisation of macroradiographic procedure,"[296.0, 1417.0, 656.0, 1459.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Standardisation of macroradiographic procedure""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 4,9,text,"Stereotaxic devices are used to position each patient accurately and reproducibly. The centre of the joint under examination (the middle phalanx in the hand, the joint space in the knee and the femora","[295.0, 1459.0, 689.0, 1607.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,10,text,,"[698.0, 113.0, 1095.0, 588.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,10,text,"knee radiography an image intensifier and +camera are used to screen the joint to ensure +that the tibial plateau is flat and parallel to the +central ray of the x ray beam and perpendicular +to the x ray","[698.0, 113.0, 1095.0, 588.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,11,text,The anatomical sites within the macroradiograph used in defining the boundaries for the measurement of a feature are described precisely. Steroscopic examination of the macroradiographs identified the,"[700.0, 586.0, 1094.0, 757.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,12,text,Femur: the distal convex margin of the condyle (fig 2).,"[703.0, 758.0, 1093.0, 800.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,13,text,"Tibia, medial compartment: a line extending from near the tibial spine to the medial or outer margin, across the centre of the floor of the articular fossa in the mid-coronal plane of the joint. This ","[701.0, 800.0, 1096.0, 1249.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -61,11 +73,15 @@ United Kingdom.","[114.0, 1496.0, 275.0, 1610.0]",frontmatter_support,0.75,"[""p 5,4,paragraph_title,Joint space width,"[313.0, 585.0, 480.0, 607.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Joint space width""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 5,5,text,Joint space narrowing is considered the most important radiological feature of OA but its accuracy in measuring true cartilage loss has been questioned. $ ^{16} $ To overcome this problem we carried o,"[311.0, 608.0, 706.0, 906.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,6,text,"In patients with early, but definite OA of the hand, JSW measurements showed that 56% of the patients had an increase in the interbone distance compared with the reference value obtained from healthy ","[313.0, 906.0, 706.0, 1058.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -5,7,text,,"[717.0, 117.0, 1112.0, 419.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +5,7,text,"wrist and hand joints, showed a significant +increase at the first carpo-metacarpal joint of +the wrist and in the proximal interphalangeal +joints of these patients.39 This feature appears +to represent ","[717.0, 117.0, 1112.0, 419.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,8,paragraph_title,"Relationship between changes in joint space, subchondral sclerosis and osteophytes","[717.0, 456.0, 1072.0, 521.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Relationship between changes in joint space, subchondral scl""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 5,9,text,The results of the studies of OA of the hand $ ^{38} $ and knee $ ^{45} $ showed that the extent of subchondral sclerosis and osteophytosis was significantly advanced in these joints in over half of t,"[717.0, 521.0, 1114.0, 1059.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -5,10,image,,"[324.0, 1090.0, 1102.0, 1539.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -5,11,figure_title,"Figure 3 Part of a macroradiograph of the metacarpo-phalangeal joints of a patient with hand OA, showing the mineralised cartilage zone extending into the existing articular cartilage space, contribut","[316.0, 1548.0, 1053.0, 1601.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 3 Part of a macroradiograph of the metacarpo-phalange""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +5,10,image,,"[324.0, 1090.0, 1102.0, 1539.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,11,figure_title,"Figure 3 Part of a macroradiograph of the metacarpo-phalangeal joints of a patient with hand OA, showing the mineralised cartilage zone extending into the existing articular cartilage space, contribut","[316.0, 1548.0, 1053.0, 1601.0]",figure_caption,0.92,"[""figure_title label: Figure 3 Part of a macroradiograph of the metacarpo-phalange""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 6,0,header,Quantitative radiography of OA,"[93.0, 67.0, 315.0, 89.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 6,1,number,273,"[1061.0, 68.0, 1093.0, 86.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,2,text,"cartilage, measured as joint space narrowing, is a late stage phenomenon of osteoarthritis.","[294.0, 124.0, 686.0, 168.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -73,7 +89,11 @@ United Kingdom.","[114.0, 1496.0, 275.0, 1610.0]",frontmatter_support,0.75,"[""p 6,4,text,"Evaluation of the pattern of joint space narrowing in the OA hand patients, during the study, showed no association between this feature and the pattern of normal force distribution in the hand, descr","[292.0, 465.0, 686.0, 959.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,5,text,"The results of these investigations show that by using accurate and precise radiographic procedures and methods of measurement, it is possible to detect early OA and to evaluate its severity and progr","[290.0, 957.0, 685.0, 1214.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,6,text,"The greater sensitivity of this technique, compared with standard radiography, has improved the chances of measuring the effect of a 'disease modifying' agent, particularly in patients with radiologic","[287.0, 1213.0, 683.0, 1614.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -6,7,text,,"[700.0, 124.0, 1096.0, 363.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +6,7,text,"just the signal or most painful knee, but also +the contra-lateral since nearly all of these joints +were found to be painful with clear radio- +pathological evidence of early OA; patients +with marked jo","[700.0, 124.0, 1096.0, 363.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,8,paragraph_title,Increasing the accuracy and reproducibility in standard radiography,"[700.0, 403.0, 1075.0, 447.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Increasing the accuracy and reproducibility in standard radi""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 6,9,footer,,"[700.0, 426.0, 1075.0, 447.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False 6,10,text,"As described above, quantitative microfocal radiography can measure progression, in hand and knee OA, within a reasonably short period of time, providing information on the natural history of the dise","[698.0, 441.0, 1093.0, 917.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -84,8 +104,8 @@ United Kingdom.","[114.0, 1496.0, 275.0, 1610.0]",frontmatter_support,0.75,"[""p 7,1,header,Buckland-Wright,"[986.0, 71.0, 1104.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False 7,2,text,analysis and overall reduce the time taken for the mensural procedures.,"[310.0, 127.0, 699.0, 173.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,3,paragraph_title,Conclusion,"[310.0, 212.0, 423.0, 233.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True -7,4,text,"To measure OA progression, it is necessary to establish a universally acceptable method for accurate and reproducible and quantitative assessment of changes in joint structure. This will require more ","[310.0, 235.0, 701.0, 705.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -7,5,text,"I wish to express my gratitude to Dr Charles Hutton for inviting me to write this article and to numerous colleagues who have collaborated in our studies in osteoarthritis, in particular Dr Diana Macf","[312.0, 721.0, 702.0, 827.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,4,text,"To measure OA progression, it is necessary to establish a universally acceptable method for accurate and reproducible and quantitative assessment of changes in joint structure. This will require more ","[310.0, 235.0, 701.0, 705.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"I wish to express my gratitude to Dr Charles Hutton for inviting me to write this article and to numerous colleagues who have collaborated in our studies in osteoarthritis, in particular Dr Diana Macf","[312.0, 721.0, 702.0, 827.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,6,reference_content,"1 Resnick D, Niwayama G. Degenerative diseases of extra-spinal locations. In: Resnick D, Niwayama G, eds. Diagnosis of bone and joint disorders, 2nd ed. Philadelphia: Saunders, 1988: 1365–479.","[323.0, 882.0, 700.0, 939.0]",reference_item,0.85,"[""reference content label: 1 Resnick D, Niwayama G. Degenerative diseases of extra-spin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 7,7,reference_content,"2 Altman R, Asch E, Block D, et al. Development of criteria for the classification and reporting of osteoarthritis. Arthritis Rheum 1986; 29: 1039–49.","[322.0, 939.0, 700.0, 982.0]",reference_item,0.85,"[""reference content label: 2 Altman R, Asch E, Block D, et al. Development of criteria ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 7,8,reference_content,"3 Altman R, Fries J F, Bloch D A, et al. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum 1987; 30: 1214–25.","[322.0, 982.0, 701.0, 1025.0]",reference_item,0.85,"[""reference content label: 3 Altman R, Fries J F, Bloch D A, et al. Radiographic assess""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/audit/CAQNW9Q2/changed_blocks_after_fallback.json b/audit/CAQNW9Q2/changed_blocks_after_fallback.json index b468ddc6..299b52c1 100644 --- a/audit/CAQNW9Q2/changed_blocks_after_fallback.json +++ b/audit/CAQNW9Q2/changed_blocks_after_fallback.json @@ -151,7 +151,7 @@ { "block_id": "p2:2", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, diff --git a/audit/CAQNW9Q2/coverage_check.json b/audit/CAQNW9Q2/coverage_check.json index b3052a79..c1c24010 100644 --- a/audit/CAQNW9Q2/coverage_check.json +++ b/audit/CAQNW9Q2/coverage_check.json @@ -19,16 +19,11 @@ "p1:8", "p1:9", "p2:2", - "p2:3", "p2:5", - "p4:10", "p4:2", "p4:3", - "p4:4", "p5:10", - "p5:11", "p5:6", - "p5:7", "p5:9", "p7:10", "p7:11", @@ -60,7 +55,6 @@ "p7:37", "p7:38", "p7:39", - "p7:4", "p7:40", "p7:41", "p7:42", @@ -71,7 +65,6 @@ "p7:47", "p7:48", "p7:49", - "p7:5", "p7:50", "p7:51", "p7:6", diff --git a/audit/CAQNW9Q2/fulltext_block_mapping_summary.json b/audit/CAQNW9Q2/fulltext_block_mapping_summary.json index e50a6c26..2bfd2fc1 100644 --- a/audit/CAQNW9Q2/fulltext_block_mapping_summary.json +++ b/audit/CAQNW9Q2/fulltext_block_mapping_summary.json @@ -1,7 +1,7 @@ { - "mappable_block_count": 139, - "found_count": 121, - "missing_count": 18, + "mappable_block_count": 140, + "found_count": 125, + "missing_count": 15, "rows": [ { "block_id": "p1:0", @@ -143,16 +143,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p2:3", - "page": 2, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Figure 1 Standard radiographic appearance of osteoarthritic knee joints showing ", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p2:4", "page": 2, @@ -233,6 +223,16 @@ "found_in_fulltext": true, "fulltext_offset": 8025 }, + { + "block_id": "p3:5", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Joint space is assessed automatically using an edge detection technique and is e", + "found_in_fulltext": true, + "fulltext_offset": 8835 + }, { "block_id": "p3:6", "page": 3, @@ -241,7 +241,7 @@ "render_default": true, "snippet": "Microfocal radiography", "found_in_fulltext": true, - "fulltext_offset": 10093 + "fulltext_offset": 11330 }, { "block_id": "p3:7", @@ -251,7 +251,7 @@ "render_default": true, "snippet": "Microfocal x ray units are characterised by an extremely small x ray source (<15", "found_in_fulltext": true, - "fulltext_offset": 10116 + "fulltext_offset": 11353 }, { "block_id": "p3:8", @@ -261,7 +261,7 @@ "render_default": true, "snippet": "Advantages of microfocal radiography are those characteristic of an extremely sm", "found_in_fulltext": true, - "fulltext_offset": 10609 + "fulltext_offset": 11846 }, { "block_id": "p4:0", @@ -283,16 +283,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p4:4", - "page": 4, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Figure 2 Part of the macroradiographs of osteoarthritic knee joints with medial ", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p4:5", "page": 4, @@ -301,7 +291,7 @@ "render_default": true, "snippet": "resolution, makes it possible to detect structural detail virtually at the histo", "found_in_fulltext": true, - "fulltext_offset": 11878 + "fulltext_offset": 13115 }, { "block_id": "p4:6", @@ -311,7 +301,7 @@ "render_default": true, "snippet": "Limitations are also a function of the small x ray source size. 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"zone": "tail_nonref_hold_zone", + "zone": "body_zone", "render_default": true, "snippet": "To measure OA progression, it is necessary to establish a universally acceptable", "found_in_fulltext": true, - "fulltext_offset": 26555 + "fulltext_offset": 29946 }, { "block_id": "p7:5", "page": 7, "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "render_default": true, "snippet": "I wish to express my gratitude to Dr Charles Hutton for inviting me to write thi", "found_in_fulltext": true, - "fulltext_offset": 27494 + "fulltext_offset": 30885 }, { "block_id": "p7:6", @@ -671,7 +681,7 @@ "render_default": true, "snippet": "1 Resnick D, Niwayama G. 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+ "p1:8", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p2:0", + "p2:7", + "p2:8", + "p2:9", + "p2:10", + "p3:0", + "p3:26", + "p3:27", + "p3:28", + "p3:29", + "p4:0" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/DAB9VMWW/audit_report.md b/audit/DAB9VMWW/audit_report.md new file mode 100644 index 00000000..fb9f8d94 --- /dev/null +++ b/audit/DAB9VMWW/audit_report.md @@ -0,0 +1,17 @@ +# OCR Truth Audit Report - DAB9VMWW + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 2, 3, 5, 7, 8, 9] +- Reviewed blocks: 167 + +## Findings + +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/DAB9VMWW/audit_scope.json b/audit/DAB9VMWW/audit_scope.json new file mode 100644 index 00000000..6e0277af --- /dev/null +++ b/audit/DAB9VMWW/audit_scope.json @@ -0,0 +1,1526 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 2, + 3, + 5, + 7, + 8, + 9 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p2:1", + "p2:2", + "p3:1", + "p3:3", + "p3:5", + "p3:7", + "p3:9", + "p3:12", + "p3:13", + "p3:16", + "p3:17", + "p3:18", + "p3:19", + "p3:20", + "p5:1", + 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+page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,RESEARCH ARTICLE,"[98.0, 53.0, 358.0, 82.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header_image,,"[1036.0, 1.0, 1191.0, 28.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,header,"ADVANCED MATERIALS +www.advmat.de","[934.0, 44.0, 1098.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,3,doc_title,"Capacitive-Coupling-Responsive Hydrogel Scaffolds +Offering Wireless In Situ Electrical Stimulation Promotes +Nerve Regeneration","[95.0, 147.0, 1039.0, 282.0]",paper_title,0.8,"[""page-1 zone title_zone: Capacitive-Coupling-Responsive Hydrogel Scaffolds\nOffering W""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"Ping Wu, Chao Xu, Xianghui Zou, Kun Yang, Yanping Xu, Xueyao Li, Xiaokun Li,* +Zhouguang Wang,* and Zhiqiang Luo*","[96.0, 314.0, 1005.0, 386.0]",authors,0.8,"[""page-1 zone author_zone: Ping Wu, Chao Xu, Xianghui Zou, Kun Yang, Yanping Xu, Xueyao""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,abstract,"Electrical stimulation (ES) has shown beneficial effects in repairing injured tissues. However, current ES techniques that use tissue-traversing leads and bulky external power suppliers have significa","[97.0, 446.0, 739.0, 946.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,6,paragraph_title,1. Introduction,"[766.0, 435.0, 914.0, 461.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,7,text,"Electrical stimulation (ES) has shown significant benefits in the repair and regeneration of damaged tissues including nerves, muscles, skin, bones, tendons, and ligaments. $ ^{[1]} $ In particular, i","[763.0, 472.0, 1099.0, 1065.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,"feasible. $ ^{[6]} $ Therefore, there is an urgent need to explore wireless ES without external bulky power sources and percutaneous leads for tissue-engineering applications.","[606.0, 1066.0, 1098.0, 1132.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,footnote,"P. Wu, C. Xu, X. Zou, K. Yang, Y. Xu, X. Li, Z. Luo +National Engineering Research Center for Nanomedicine +College of Life Science and Technology +Huazhong University of Science and Technology +Wuhan 430","[96.0, 1071.0, 572.0, 1356.0]",footnote,0.7,"[""footnote label: P. Wu, C. Xu, X. Zou, K. Yang, Y. Xu, X. Li, Z. Luo\nNational""]",footnote,0.7,body_zone,body_like,none,True,True +1,10,text,"To avoid invasive percutaneous leads during in vivo ES, implantable mini-sized devices that can generate electrical currents to assist in tissue regeneration have been explored. 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Mater. 2024, 36, 2310483","[98.0, 1487.0, 277.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,14,number,2310483 (1 of 10),"[530.0, 1484.0, 665.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,15,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 338.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[928.0, 44.0, 1092.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,2,image,,"[116.0, 167.0, 1072.0, 773.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,3,figure_title,"Figure 1. Schematics of wireless electrical stimulation based on conductive and biodegradable hydrogels for spinal cord repair. Owing to the capacitive coupling configuration, the electrostatic induct","[89.0, 785.0, 1095.0, 938.0]",figure_caption,0.92,"[""figure_title label: Figure 1. Schematics of wireless electrical stimulation base""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,4,text,"by an external magnetic field, and the ES delivered to the cuff electrodes wrapped around the damaged sciatic nerve facilitates peripheral nerve regeneration. Despite these advances, the application o","[89.0, 981.0, 582.0, 1179.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,We speculate that an electroactive biomaterial capable of functioning both as a biodegradable regeneration scaffold and wireless ES platform could overcome the aforementioned challenges. In this situa,"[90.0, 1180.0, 581.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"gel scaffold with capacitive-coupling wireless electrical gener- +ation capability for successful spinal cord injury (SCI) repair +(Figure 1). The biodegradable conductive scaffold was composed +of a chito","[600.0, 980.0, 1093.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,footer,"Adv. Mater. 2024, 36, 2310483","[93.0, 1487.0, 271.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,8,number,2310483 (2 of 10),"[524.0, 1484.0, 658.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,9,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,10,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155.0, 30.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[934.0, 44.0, 1097.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,2,figure_title,a,"[127.0, 159.0, 147.0, 181.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,3,image,,"[140.0, 159.0, 346.0, 355.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,b,"[355.0, 152.0, 373.0, 181.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,5,image,,"[377.0, 165.0, 577.0, 355.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,C,"[589.0, 157.0, 608.0, 181.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,7,image,,"[611.0, 172.0, 816.0, 359.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,8,figure_title,d,"[838.0, 154.0, 859.0, 181.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,9,chart,,"[836.0, 175.0, 1075.0, 382.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,10,figure_title,e,"[128.0, 372.0, 150.0, 393.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,11,figure_title,f,"[355.0, 366.0, 371.0, 394.0]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,12,chart,,"[120.0, 388.0, 361.0, 586.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,13,chart,,"[350.0, 376.0, 596.0, 590.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,14,figure_title,g,"[582.0, 372.0, 602.0, 399.0]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,15,figure_title,h,"[842.0, 367.0, 862.0, 395.0]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,16,chart,,"[586.0, 387.0, 826.0, 587.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,17,chart,,"[832.0, 396.0, 1082.0, 587.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,18,chart,,"[113.0, 589.0, 352.0, 801.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,19,chart,,"[362.0, 594.0, 837.0, 807.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,20,chart,,"[841.0, 593.0, 1070.0, 805.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,21,figure_title,Figure 2. Fabrication and characterization of CS/Gel/BP conductive hydrogels. a) TEM image of BP nanosheet. b) AFM image of BP nanosheet. c) SEM image of dehydrated CS/Gel/BP hydrogel. d) Rheological ,"[96.0, 817.0, 1101.0, 952.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Fabrication and characterization of CS/Gel/BP cond""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,22,text,enhancing neural regeneration and the regeneration of other tissues.,"[95.0, 982.0, 587.0, 1027.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,23,paragraph_title,2. Results and Discussion,"[96.0, 1054.0, 350.0, 1078.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Results and Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,24,text,"Biodegradable conductive hydrogels provide a conductive microenvironment that enhances the repair of electroactive tissues.[11] In this study, we explored a wireless ES strategy based on biodegradable","[95.0, 1091.0, 588.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,25,text,"(BP) nanosheets have been explored as conductive dopants for +constructing conductive hydrogels for neural tissue-engineering +applications.[14] BP nanosheets possess excellent biocompatibil- +ity and bi","[605.0, 981.0, 1099.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,26,footer,"Adv. Mater. 2024, 36, 2310483","[98.0, 1487.0, 277.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,27,number,2310483 (3 of 10),"[530.0, 1484.0, 664.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,28,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,29,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155.0, 32.0, 1171.0, 1536.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +4,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header_image,,"[928.0, 44.0, 1091.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +4,2,text,"located at 1156 and 1067 cm⁻¹, which can be assigned to the P=O and P−O oxygen functionalities, respectively, resulting from the surface oxidation of BP. Moreover, the peaks between ≈1280 and ≈1510 cm","[89.0, 148.0, 582.0, 325.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"After mixing the BP@PDA nanosheets evenly in the chitosan/gelatin solution, a stable composite chitosan/gelatin/black phosphorus (CS/Gel/BP) hydrogel (BCH) was formed by adding the crosslinking agent ","[89.0, 331.0, 583.0, 1246.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,text,Capacitive coupling technology is a promising near-field coupling approach for wireless power transfer developed for consumer electronics and vehicles.[16] To avoid complicated device construction usi,"[89.0, 1245.0, 582.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"responsive hydrogel scaffold with alternating current flow dur- +ing high-frequency charging and discharging can function as an +electroactive biomaterial for tissue engineering applications. The +CS/Gel/B","[598.0, 149.0, 1092.0, 655.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"Before investigating the in vitro NSC behavior on a conductive CS/Gel/BP hydrogel with electrostatic induction-driven in situ ES, the biocompatibility of the BCH was studied. A cell contact assay was ","[600.0, 654.0, 1093.0, 1094.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"To evaluate the effect of electrostatic-induction-driven in situ WES on cell proliferation, the cell growth density of NSCs on the CS/Gel/BP hydrogels was determined using Ki67 immunofluorescence stai","[599.0, 1094.0, 1093.0, 1443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,footer,"Adv. Mater. 2024, 36, 2310483","[93.0, 1487.0, 271.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,9,footer,2310483 (4 of 10),"[524.0, 1484.0, 658.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,10,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,11,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155.0, 30.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[97.0, 45.0, 346.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header_image,,"[934.0, 44.0, 1097.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,2,image,,"[123.0, 149.0, 332.0, 513.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,chart,,"[319.0, 157.0, 500.0, 332.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,4,chart,,"[523.0, 166.0, 666.0, 330.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,chart,,"[684.0, 167.0, 832.0, 330.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,chart,,"[348.0, 336.0, 500.0, 495.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,7,chart,,"[840.0, 166.0, 1070.0, 343.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,chart,,"[520.0, 337.0, 666.0, 505.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,9,chart,,"[685.0, 337.0, 841.0, 500.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,10,chart,,"[845.0, 348.0, 1073.0, 532.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,11,image,,"[113.0, 528.0, 447.0, 859.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,12,image,,"[455.0, 527.0, 629.0, 858.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,13,image,,"[629.0, 547.0, 776.0, 857.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,image,,"[778.0, 551.0, 925.0, 857.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,15,image,,"[925.0, 550.0, 1079.0, 858.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,16,chart,,"[113.0, 866.0, 362.0, 1069.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,17,chart,,"[352.0, 865.0, 583.0, 1058.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,18,chart,,"[584.0, 864.0, 825.0, 1057.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,19,figure_title,k,"[118.0, 1051.0, 138.0, 1077.0]",figure_inner_text,0.9,"[""panel label / figure inner text: k""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,20,chart,,"[830.0, 861.0, 1077.0, 1059.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,21,figure_title,m,"[582.0, 1055.0, 609.0, 1078.0]",figure_inner_text,0.9,"[""panel label / figure inner text: m""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,22,chart,,"[121.0, 1082.0, 356.0, 1244.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,23,figure_title,n,"[826.0, 1055.0, 847.0, 1078.0]",figure_inner_text,0.9,"[""panel label / figure inner text: n""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,24,chart,,"[356.0, 1082.0, 583.0, 1245.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,25,chart,,"[590.0, 1081.0, 831.0, 1244.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,26,chart,,"[838.0, 1079.0, 1075.0, 1244.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,27,figure_title,"Figure 3. BCH with wireless in situ ES promotes NSC proliferation, differentiation, and neurotrophic factor secretion. a) Schematic of wireless electrical stimulation (WES) for NSC regulation. b,c) Ef","[96.0, 1251.0, 1099.0, 1406.0]",figure_caption,0.92,"[""figure_title label: Figure 3. BCH with wireless in situ ES promotes NSC prolifer""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,28,footer,"Adv. Mater. 2024, 36, 2310483","[99.0, 1487.0, 276.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,29,number,2310483 (5 of 10),"[530.0, 1484.0, 664.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,30,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,31,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155.0, 30.0, 1171.0, 1542.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92.0, 46.0, 338.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +6,1,header_image,,"[929.0, 45.0, 1091.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +6,2,text,"in situ ES on NSC differentiation was also investigated. After 7 d of WES, with 20 min of treatment per day, immunofluorescence staining for Tuj1, a neural marker for neuron-specific microtubule eleme","[90.0, 149.0, 582.0, 805.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +6,3,text,"To investigate in vivo therapeutic effect of the wireless ES generated by the capacitive-coupling-responsive CS/Gel/BP hydrogel, an SCI model with a completely transected T9 segment was established us","[90.0, 807.0, 583.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +6,4,text,"2.75 V. Therefore, the in vivo and in vitro coupling efficiency for +power transmission appears to be similar.","[601.0, 148.0, 1092.0, 193.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,heading_numbered,True,True +6,5,text,"The effect of the BCH combined with electrostatic-induction-driven WES in promoting locomotor functional recovery was evaluated using Basso–Beattie–Bresnahan (BBB) locomotion scores recorded weekly, a","[599.0, 193.0, 1093.0, 609.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +6,6,text,Urinary system disorders are serious complications of spinal cord injury that cause irreversible pathological changes in the bladder and greatly affect the quality of life of patients. Effective recov,"[600.0, 611.0, 1093.0, 1114.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +6,7,text,"Luxol fast blue (LFB), a copper-phthalocyanine dye, combines with myelin in an ethanol solution to enhance the staining of the myelin sheath.[20] The histological morphologies of the cavity area and m","[599.0, 1114.0, 1094.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +6,8,footer,"Adv. Mater. 2024, 36, 2310483","[93.0, 1487.0, 271.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +6,9,footer,2310483 (6 of 10),"[524.0, 1484.0, 658.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +6,10,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +6,11,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. 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BCH with wireless in situ ES promotes SCI animal functional recovery and neural regeneration. a) BBB scores of rats in each group, n = 6. b) Weights of bladders in different groups, n = 4. c","[96.0, 1147.0, 1096.0, 1302.0]",figure_caption,0.92,"[""figure_title label: Figure 4. BCH with wireless in situ ES promotes SCI animal f""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,25,text,analysis results are shown in Figure 4g. The LFB staining ratio of the total area significantly increased in the ES-treated group at week 8 post-injury compared to that in the BCH or SCI groups (P < 0,"[95.0, 1332.0, 587.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +7,26,text,"ES-treated groups. These results demonstrate that the BCH com- +bined with the intermediate ES dose could synergistically and ef- +fectively improve pathological function after SCI.","[606.0, 1332.0, 1097.0, 1398.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +7,27,text,"The myelin sheath, the membrane that surrounds the axon, can act as an insulator to prevent the transmission of electrical","[607.0, 1400.0, 1098.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +7,28,footer,"Adv. Mater. 2024, 36, 2310483","[99.0, 1487.0, 276.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +7,29,number,2310483 (7 of 10),"[530.0, 1484.0, 664.0, 1507.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +7,30,footer,© 2024 Wiley-VCH GmbH,"[937.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +7,31,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. 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BCH with wireless in situ ES promotes neural stem cell differentiation and BDNF/c-fos expression. a) Representative images showing Tuj1 (red, a neural biomarker of neuron-specific microtubul","[90.0, 1109.0, 1090.0, 1226.0]",figure_caption,0.92,"[""figure_title label: Figure 5. BCH with wireless in situ ES promotes neural stem ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,13,text,"impulses from one axon to another. Myelination at the site of a nerve injury provides a protective barrier against axonal regeneration. Myelin basic protein (MBP), a special biomarker of myelination d","[89.0, 1266.0, 582.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +8,14,text,"nerves (Figure 4e). As shown in Figure 4h,i, the mean percentage +of MBP/NF200+ staining in the BCH-M group was much higher +than that in the SCI, BCH, BCH-L, or BCH-H groups, and the +mean percentage of","[599.0, 1267.0, 1093.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +8,15,footer,"Adv. Mater. 2024, 36, 2310483","[93.0, 1487.0, 271.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,16,number,2310483 (8 of 10),"[524.0, 1484.0, 658.0, 1508.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +8,17,footer,© 2024 Wiley-VCH GmbH,"[931.0, 1487.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,18,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155.0, 28.0, 1171.0, 1540.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98.0, 45.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +9,1,header_image,,"[934.0, 45.0, 1096.0, 116.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +9,2,text,"medium dose had a strong influence on strengthening remyelination. As shown in Figure S12 (Supporting Information), classic myelin-wrapped nerve fiber structures were observed in the nerve regeneratio","[95.0, 149.0, 587.0, 347.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"To assess the differentiation of endogenous NSC differentiation at the injury sites eight weeks after surgery, IF co-staining of Tuj1 and GFAP was performed (Figure 5a). $ ^{[22]} $ Tuj1 is a neural b","[96.0, 346.0, 588.0, 1028.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,4,paragraph_title,3. Conclusions,"[98.0, 1054.0, 244.0, 1078.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Conclusions""]",section_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True +9,5,text,"In this study, we developed a WES strategy, in which a capacitive-coupling-responsive conductive hydrogel served simultaneously as a biodegradable regeneration scaffold and in situ wireless ES platfor","[96.0, 1092.0, 587.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,6,text,"fectively promote functional repair by enhancing remyelination, +accelerating axonal regeneration, facilitating the differentiation +of endogenous NSCs, and activating calcium downstream signal- +ing path","[606.0, 149.0, 1098.0, 283.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,paragraph_title,Supporting Information,"[608.0, 324.0, 840.0, 351.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supporting Information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True +9,8,text,Supporting Information is available from the Wiley Online Library or from the author.,"[607.0, 361.0, 1096.0, 401.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,paragraph_title,Acknowledgements,"[608.0, 443.0, 801.0, 469.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +9,10,text,"P.W., C.X., and X.Z. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (82202352, 82302405, 81771974, and 82271629).","[606.0, 481.0, 1097.0, 540.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,11,paragraph_title,Conflict of Interest,"[608.0, 582.0, 792.0, 608.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,False,True +9,12,text,The authors declare no conflict of interest.,"[608.0, 620.0, 894.0, 641.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +9,13,paragraph_title,Data Availability Statement,"[609.0, 684.0, 872.0, 708.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data Availability Statement""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,14,text,The data that support the findings of this study are available from the corresponding author upon reasonable request.,"[606.0, 721.0, 1097.0, 761.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,15,paragraph_title,Keywords,"[608.0, 803.0, 707.0, 830.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Keywords""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +9,16,text,"biodegradable hydrogels, conductive hydrogels, neural regeneration, tissue engineering, wireless electrical stimulation","[607.0, 840.0, 1097.0, 881.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,17,text,"Received: October 9, 2023 +Revised: December 28, 2023 +Published online: January 14, 2024","[865.0, 902.0, 1097.0, 961.0]",backmatter_body,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,True,True +9,18,reference_content,"[1] a) L. 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Yang, Biomaterials 2020, 255, 120164.","[617.0, 1324.0, 1097.0, 1361.0]",reference_item,0.85,"[""reference content label: [3] Y. Zhao, Y. Liang, S. Ding, K. Zhang, H.-Q. Mao, Y. Yang""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +9,21,reference_content,"[4] Y. Ping, C. Xu, L. Xu, G. Liao, Y. Zhou, C. Deng, Y. Lan, F. Yu, J. Shi, L. Wang, Y. Xiao, X. Li, Front. Bioeng. Biotechnol. 2020, 8, 709.","[619.0, 1363.0, 1095.0, 1401.0]",reference_item,0.85,"[""reference content label: [4] Y. Ping, C. Xu, L. Xu, G. Liao, Y. Zhou, C. Deng, Y. Lan""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +9,22,reference_content,"[5] S. Xie, J. Huang, A. T. Pereira, L. Xu, D. Luo, Z. Li, BMEMat 2023, 1, 12038.","[618.0, 1404.0, 1095.0, 1440.0]",reference_item,0.85,"[""reference content label: [5] S. Xie, J. Huang, A. T. Pereira, L. Xu, D. Luo, Z. Li, B""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +9,23,footer,"Adv. Mater. 2024, 36, 2310483","[99.0, 1487.0, 277.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +9,24,footer,2310483 (9 of 10),"[530.0, 1484.0, 664.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +9,25,footer,© 2024 Wiley-VCH GmbH,"[938.0, 1487.0, 1096.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +9,26,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. 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Luo,", + "found_in_fulltext": true, + "fulltext_offset": 39401 + }, + { + "block_id": "p10:16", + "page": 10, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[19] L. Li, Y. Zhang, J. Mu, J. Chen, C. Zhang, H. Cao, J. Gao, Nano Lett. 2020,", + "found_in_fulltext": true, + "fulltext_offset": 39797 + }, + { + "block_id": "p10:17", + "page": 10, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[20] Y. Bi, W. Duan, J. Chen, T. You, S. Li, W. Jiang, M. Li, G. Wang, X. Pan, J", + "found_in_fulltext": true, + "fulltext_offset": 39888 + }, + { + "block_id": "p10:18", + "page": 10, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[21] W. Tai, W. Wu, L.-L. Wang, H. Ni, C. Chen, J. Yang, T. Zang, Y. Zou, X.-M. 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"p26:10", "p26:11", + "p35:0", + "p35:1", + "p35:2", + "p35:3", + "p35:4", "p37:0", "p37:1", "p37:2", @@ -206,8 +207,6 @@ "p39:17", "p39:18", "p39:19", - "p40:0", - "p40:1", "p41:0", "p41:1", "p41:2", @@ -525,6 +524,8 @@ "p2:3", "p2:4", "p2:5", + "p2:6", + "p2:7", "p13:1", "p21:1", "p35:2", @@ -536,7 +537,6 @@ "p38:7", "p38:10", "p38:15", - "p38:31", "p39:18", "p41:13" ], diff --git a/audit/DWQQK2YB/audit_report.md b/audit/DWQQK2YB/audit_report.md index 5a157e72..babd2a06 100644 --- a/audit/DWQQK2YB/audit_report.md +++ b/audit/DWQQK2YB/audit_report.md @@ -2,8 +2,8 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [2, 25, 26, 37, 38, 39, 40, 41] -- Reviewed blocks: 103 +- Reviewed pages: [2, 26, 35, 37, 38, 39, 41] +- Reviewed blocks: 100 ## Findings diff --git a/audit/DWQQK2YB/audit_scope.json b/audit/DWQQK2YB/audit_scope.json index 68fa4eed..d8d2c708 100644 --- a/audit/DWQQK2YB/audit_scope.json +++ b/audit/DWQQK2YB/audit_scope.json @@ -2,12 +2,11 @@ "mode": "high-risk", "selected_pages": [ 2, - 25, 26, + 35, 37, 38, 39, - 40, 41 ], "required_block_ids": [ @@ -19,12 +18,6 @@ "p2:5", "p2:6", "p2:7", - "p25:0", - "p25:1", - "p25:2", - "p25:3", - "p25:4", - "p25:5", "p26:0", "p26:1", "p26:2", @@ -37,6 +30,11 @@ "p26:9", "p26:10", "p26:11", + "p35:0", + "p35:1", + "p35:2", + "p35:3", + "p35:4", "p37:0", "p37:1", "p37:2", @@ -65,15 +63,11 @@ "p38:20", "p38:21", "p38:22", - "p38:23", "p38:24", - "p38:25", "p38:26", "p38:27", - "p38:28", "p38:29", "p38:30", - "p38:31", "p39:0", "p39:1", "p39:2", @@ -94,8 +88,6 @@ "p39:17", "p39:18", "p39:19", - "p40:0", - "p40:1", "p41:0", "p41:1", "p41:2", @@ -146,7 +138,7 @@ "block_id": "p2:2", "page": 2, "required_reason": [ - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -176,7 +168,7 @@ "block_id": "p2:4", "page": 2, "required_reason": [ - "frontmatter" + "needs_resolution" ], "minimum_fields": [ "block_id", @@ -232,96 +224,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p25:0", - "page": 25, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:1", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:2", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:3", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:4", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:5", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p26:0", "page": 26, @@ -502,6 +404,84 @@ "truth_reference_membership" ] }, + { + "block_id": "p35:0", + "page": 35, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p35:1", + "page": 35, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p35:2", + "page": 35, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p35:3", + "page": 35, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p35:4", + "page": 35, + "required_reason": [ + "backmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, { "block_id": "p37:0", "page": 37, @@ -521,8 +501,7 @@ "block_id": "p37:1", "page": 37, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -553,8 +532,7 @@ "block_id": "p37:3", "page": 37, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -600,8 +578,7 @@ "block_id": "p38:1", "page": 38, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -792,8 +769,7 @@ "block_id": "p38:13", "page": 38, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -840,8 +816,7 @@ "block_id": "p38:16", "page": 38, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -948,22 +923,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p38:23", - "page": 38, - "required_reason": [ - "backmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p38:24", "page": 38, @@ -980,22 +939,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p38:25", - "page": 38, - "required_reason": [ - "backmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p38:26", "page": 38, @@ -1028,22 +971,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p38:28", - "page": 38, - "required_reason": [ - "backmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p38:29", "page": 38, @@ -1076,21 +1003,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p38:31", - "page": 38, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p39:0", "page": 39, @@ -1110,8 +1022,7 @@ "block_id": "p39:1", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1142,8 +1053,7 @@ "block_id": "p39:3", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1174,8 +1084,7 @@ "block_id": "p39:5", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1206,8 +1115,7 @@ "block_id": "p39:7", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1270,8 +1178,7 @@ "block_id": "p39:11", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1286,8 +1193,7 @@ "block_id": "p39:12", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1334,8 +1240,7 @@ "block_id": "p39:15", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1350,8 +1255,7 @@ "block_id": "p39:16", "page": 39, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1410,37 +1314,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p40:0", - "page": 40, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p40:1", - "page": 40, - "required_reason": [ - "backmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p41:0", "page": 41, @@ -1460,8 +1333,7 @@ "block_id": "p41:1", "page": 41, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1492,8 +1364,7 @@ "block_id": "p41:3", "page": 41, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1524,8 +1395,7 @@ "block_id": "p41:5", "page": 41, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1556,8 +1426,7 @@ "block_id": "p41:7", "page": 41, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1604,8 +1473,7 @@ "block_id": "p41:10", "page": 41, "required_reason": [ - "backmatter", - "object_ownership" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1671,16 +1539,16 @@ "must_review_page": true, "required_block_count": 8 }, - { - "page": 25, - "must_review_page": true, - "required_block_count": 6 - }, { "page": 26, "must_review_page": true, "required_block_count": 12 }, + { + "page": 35, + "must_review_page": true, + "required_block_count": 5 + }, { "page": 37, "must_review_page": true, @@ -1689,18 +1557,13 @@ { "page": 38, "must_review_page": true, - "required_block_count": 32 + "required_block_count": 28 }, { "page": 39, "must_review_page": true, "required_block_count": 20 }, - { - "page": 40, - "must_review_page": true, - "required_block_count": 2 - }, { "page": 41, "must_review_page": true, diff --git a/audit/DWQQK2YB/block_coverage_summary.json b/audit/DWQQK2YB/block_coverage_summary.json index 245b6474..470e5a00 100644 --- a/audit/DWQQK2YB/block_coverage_summary.json +++ b/audit/DWQQK2YB/block_coverage_summary.json @@ -113,7 +113,7 @@ "page": 2, "raw_label": "text", "role": "unknown_structural", - "zone": "frontmatter_side_zone", + "zone": "frontmatter_main_zone", "bbox": [ 76.0, 101.0, @@ -132,8 +132,8 @@ "block_id": "p2:2", "page": 2, "raw_label": "doc_title", - "role": "unknown_structural", - "zone": "body_zone", + "role": "paper_title", + "zone": "frontmatter_main_zone", "bbox": [ 74.0, 155.0, @@ -152,8 +152,8 @@ "block_id": "p2:3", "page": 2, "raw_label": "text", - "role": "frontmatter_support", - "zone": "body_zone", + "role": "authors", + "zone": "frontmatter_main_zone", "bbox": [ 74.0, 355.0, @@ -172,8 +172,8 @@ "block_id": "p2:4", "page": 2, "raw_label": "text", - "role": "frontmatter_support", - "zone": "body_zone", + "role": "unknown_structural", + "zone": "frontmatter_main_zone", "bbox": [ 82.0, 535.0, @@ -192,8 +192,8 @@ "block_id": "p2:5", "page": 2, "raw_label": "text", - "role": "frontmatter_support", - "zone": "body_zone", + "role": "affiliation", + "zone": "frontmatter_main_zone", "bbox": [ 81.0, 645.0, @@ -212,8 +212,8 @@ "block_id": "p2:6", "page": 2, "raw_label": "text", - "role": "frontmatter_noise", - "zone": "frontmatter_side_zone", + "role": "frontmatter_support", + "zone": "frontmatter_main_zone", "bbox": [ 75.0, 811.0, @@ -232,8 +232,8 @@ "block_id": "p2:7", "page": 2, "raw_label": "text", - "role": "frontmatter_noise", - "zone": "frontmatter_side_zone", + "role": "frontmatter_support", + "zone": "frontmatter_main_zone", "bbox": [ 74.0, 864.0, @@ -2233,7 +2233,7 @@ "page": 25, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 75.0, 100.0, @@ -2252,8 +2252,8 @@ "block_id": "p25:2", "page": 25, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "tail_nonref_hold_zone", + "role": "subsection_heading", + "zone": "frontmatter_side_zone", "bbox": [ 76.0, 241.0, @@ -2272,8 +2272,8 @@ "block_id": "p25:3", "page": 25, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 75.0, 359.0, @@ -2292,8 +2292,8 @@ "block_id": "p25:4", "page": 25, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "tail_nonref_hold_zone", + "role": "sub_subsection_heading", + "zone": "body_zone", "bbox": [ 76.0, 444.0, @@ -2312,8 +2312,8 @@ "block_id": "p25:5", "page": 25, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 74.0, 518.0, @@ -3652,7 +3652,7 @@ "block_id": "p32:2", "page": 32, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "post_reference_backmatter_zone", "bbox": [ 81.0, @@ -3952,7 +3952,7 @@ "block_id": "p35:1", "page": 35, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "post_reference_backmatter_zone", "bbox": [ 76.0, @@ -4092,7 +4092,7 @@ "block_id": "p37:1", "page": 37, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 118.0, @@ -4112,7 +4112,7 @@ "block_id": "p37:2", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 114.0, @@ -4132,7 +4132,7 @@ "block_id": "p37:3", "page": 37, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 707.0, @@ -4192,7 +4192,7 @@ "block_id": "p38:1", "page": 38, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 94.0, @@ -4212,7 +4212,7 @@ "block_id": "p38:2", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 91.0, @@ -4252,7 +4252,7 @@ "block_id": "p38:4", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 92.0, @@ -4272,7 +4272,7 @@ "block_id": "p38:5", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 192.0, @@ -4332,7 +4332,7 @@ "block_id": "p38:8", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 193.0, @@ -4352,7 +4352,7 @@ "block_id": "p38:9", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 291.0, @@ -4392,7 +4392,7 @@ "block_id": "p38:11", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 295.0, @@ -4412,7 +4412,7 @@ "block_id": "p38:12", "page": 38, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 399.0, @@ -4432,7 +4432,7 @@ "block_id": "p38:13", "page": 38, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 620.0, @@ -4452,7 +4452,7 @@ "block_id": "p38:14", "page": 38, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 628.0, @@ -4492,7 +4492,7 @@ "block_id": "p38:16", "page": 38, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 427.0, @@ -4512,7 +4512,7 @@ "block_id": "p38:17", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 93.0, @@ -4532,7 +4532,7 @@ "block_id": "p38:18", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 427.0, @@ -4552,7 +4552,7 @@ "block_id": "p38:19", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 590.0, @@ -4572,7 +4572,7 @@ "block_id": "p38:20", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 701.0, @@ -4592,7 +4592,7 @@ "block_id": "p38:21", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 811.0, @@ -4612,7 +4612,7 @@ "block_id": "p38:22", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 923.0, @@ -4632,8 +4632,8 @@ "block_id": "p38:23", "page": 38, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 95.0, 637.0, @@ -4652,7 +4652,7 @@ "block_id": "p38:24", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 101.0, @@ -4672,8 +4672,8 @@ "block_id": "p38:25", "page": 38, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 243.0, 636.0, @@ -4692,7 +4692,7 @@ "block_id": "p38:26", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 248.0, @@ -4712,7 +4712,7 @@ "block_id": "p38:27", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 396.0, @@ -4732,8 +4732,8 @@ "block_id": "p38:28", "page": 38, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 648.0, 637.0, @@ -4752,7 +4752,7 @@ "block_id": "p38:29", "page": 38, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 522.0, @@ -4772,7 +4772,7 @@ "block_id": "p38:30", "page": 38, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 652.0, @@ -4792,7 +4792,7 @@ "block_id": "p38:31", "page": 38, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 73.0, @@ -4832,7 +4832,7 @@ "block_id": "p39:1", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 264.0, @@ -4872,7 +4872,7 @@ "block_id": "p39:3", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 593.0, @@ -4912,7 +4912,7 @@ "block_id": "p39:5", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 265.0, @@ -4952,7 +4952,7 @@ "block_id": "p39:7", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 521.0, @@ -5032,7 +5032,7 @@ "block_id": "p39:11", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 264.0, @@ -5052,7 +5052,7 @@ "block_id": "p39:12", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 526.0, @@ -5112,7 +5112,7 @@ "block_id": "p39:15", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 264.0, @@ -5132,7 +5132,7 @@ "block_id": "p39:16", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 550.0, @@ -5272,7 +5272,7 @@ "block_id": "p41:1", "page": 41, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 234.0, @@ -5292,7 +5292,7 @@ "block_id": "p41:2", "page": 41, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 236.0, @@ -5312,7 +5312,7 @@ "block_id": "p41:3", "page": 41, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 232.0, @@ -5332,7 +5332,7 @@ "block_id": "p41:4", "page": 41, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 255.0, @@ -5352,7 +5352,7 @@ "block_id": "p41:5", "page": 41, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 576.0, @@ -5372,7 +5372,7 @@ "block_id": "p41:6", "page": 41, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 589.0, @@ -5392,7 +5392,7 @@ "block_id": "p41:7", "page": 41, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 233.0, @@ -5412,7 +5412,7 @@ "block_id": "p41:8", "page": 41, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 258.0, @@ -5432,7 +5432,7 @@ "block_id": "p41:9", "page": 41, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 567.0, @@ -5452,7 +5452,7 @@ "block_id": "p41:10", "page": 41, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "post_reference_backmatter_zone", "bbox": [ 232.0, @@ -5472,7 +5472,7 @@ "block_id": "p41:11", "page": 41, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 241.0, @@ -5492,7 +5492,7 @@ "block_id": "p41:12", "page": 41, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "post_reference_backmatter_zone", "bbox": [ 601.0, diff --git a/audit/DWQQK2YB/block_review.jsonl b/audit/DWQQK2YB/block_review.jsonl index 494bc6d0..5fc9f93d 100644 --- a/audit/DWQQK2YB/block_review.jsonl +++ b/audit/DWQQK2YB/block_review.jsonl @@ -31,35 +31,35 @@ {"block_id": "p37:4", "page": 37, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_037.png", "method": "visual+bbox"}, "short_reason": "Figure 1 full caption text. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} {"block_id": "p38:0", "page": 38, "review_status": "reviewed", "truth_role": "frontmatter_noise", "truth_zone": "preproof_cover_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Journal Pre-proof watermark. Pipeline correct.", "_pipeline_verified": true, "_current_role": "frontmatter_noise"} {"block_id": "p38:1", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (a) for Figure 2. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} -{"block_id": "p38:2", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:2", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:3", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Concentration label 0 mg/mL within Figure 2 sub-panel. Pipeline figure_caption_candidate acceptable; zone must be display_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:4", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:5", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:4", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:5", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:6", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Concentration label 0.3 mg/mL. Pipeline figure_caption_candidate acceptable; zone must be display_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:7", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Concentration label 0.1 mg/mL. Pipeline figure_caption_candidate acceptable; zone must be display_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:8", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:9", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:8", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:9", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:10", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Concentration label 0.4 mg/mL. Pipeline figure_caption_candidate acceptable; zone must be display_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:11", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:11", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:12", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 bar chart sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:13", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (b) for Figure 2. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} {"block_id": "p38:14", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image sub-panel. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:15", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (c) for Figure 2. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:16", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (d) for Figure 2. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} -{"block_id": "p38:17", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:18", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:19", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:20", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:21", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:22", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:17", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:18", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:19", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:20", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:21", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:22", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:23", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (e) for Figure 2. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} -{"block_id": "p38:24", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:24", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:25", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (f) for Figure 2. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} -{"block_id": "p38:26", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:27", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:26", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:27", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:28", "page": 38, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (g) for Figure 2. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} -{"block_id": "p38:29", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p38:30", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:29", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p38:30", "page": 38, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p38:31", "page": 38, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_038.png", "method": "visual+bbox"}, "short_reason": "Figure 2 full caption. Pipeline figure_caption_candidate acceptable; zone display_zone correct.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p39:0", "page": 39, "review_status": "reviewed", "truth_role": "frontmatter_noise", "truth_zone": "preproof_cover_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_039.png", "method": "visual+bbox"}, "short_reason": "Journal Pre-proof watermark. Pipeline correct.", "_pipeline_verified": true, "_current_role": "frontmatter_noise"} {"block_id": "p39:1", "page": 39, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_039.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (a) for Figure 3. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} @@ -80,7 +80,7 @@ {"block_id": "p39:16", "page": 39, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_039.png", "method": "visual+bbox"}, "short_reason": "Sub-panel label (h) for Figure 3. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} {"block_id": "p39:17", "page": 39, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_039.png", "method": "visual+bbox"}, "short_reason": "Figure 3 arthroscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p39:18", "page": 39, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_039.png", "method": "visual+bbox"}, "short_reason": "Knee cartilage label within Figure 3. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone"} -{"block_id": "p39:19", "page": 39, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_039.png", "method": "visual+bbox"}, "short_reason": "Figure 3 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} +{"block_id": "p39:19", "page": 39, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_039.png", "method": "visual+bbox"}, "short_reason": "Figure 3 microscopy image. Pipeline media_asset correct; zone must be display_zone not post_reference_backmatter_zone.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "post_reference_backmatter_zone"} {"block_id": "p40:0", "page": 40, "review_status": "reviewed", "truth_role": "frontmatter_noise", "truth_zone": "preproof_cover_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_040.png", "method": "visual+bbox"}, "short_reason": "Journal Pre-proof watermark. Pipeline correct.", "_pipeline_verified": true, "_current_role": "frontmatter_noise"} {"block_id": "p40:1", "page": 40, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_040.png", "method": "visual+bbox"}, "short_reason": "Figure 3 full caption. Pipeline figure_caption_candidate acceptable; zone must be display_zone not post_reference_backmatter_zone.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "post_reference_backmatter_zone", "_pipeline_verified": true} {"block_id": "p41:0", "page": 41, "review_status": "reviewed", "truth_role": "frontmatter_noise", "truth_zone": "preproof_cover_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_041.png", "method": "visual+bbox"}, "short_reason": "Journal Pre-proof watermark. Pipeline correct.", "_pipeline_verified": true, "_current_role": "frontmatter_noise"} diff --git a/audit/DWQQK2YB/block_trace.csv b/audit/DWQQK2YB/block_trace.csv index 888ef58b..0c087433 100644 --- a/audit/DWQQK2YB/block_trace.csv +++ b/audit/DWQQK2YB/block_trace.csv @@ -1,13 +1,13 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default -2,0,header,Journal Pre-proof,"[502.0, 1.0, 832.0, 40.0]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p2 y=1/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False -2,1,text,TITLE,"[76.0, 101.0, 146.0, 128.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_side_zone,support_like,short_fragment,False,True +2,0,header,Journal Pre-proof,"[502.0, 1.0, 832.0, 40.0]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p2 y=1/1584"", ""page_1_preproof_cover_dropped_upstream""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +2,1,text,TITLE,"[76.0, 101.0, 146.0, 128.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True 2,2,doc_title,"Magnetoresponsive Stem Cell Spheroid-based Cartilage Recovery -Platform Utilizing Electromagnetic Fields","[74.0, 155.0, 1028.0, 268.0]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,body_zone,body_like,none,False,True -2,3,text,"Ami Yooa, †, Gwangjun Goa, b, †, Kim Tien Nguyena, b, Kyungmin Leea, b, Hyun-Ki Mina, Byungjeon Kanga","[74.0, 355.0, 1026.0, 445.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,4,text,"a. Korea Institute of Medical Microrobotics, 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju, 61011, Korea","[82.0, 535.0, 1028.0, 621.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,5,text,"b. School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Korea","[81.0, 645.0, 1028.0, 732.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,6,text,These authors contributed equally to this work.,"[75.0, 811.0, 548.0, 843.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False -2,7,text,"*Corresponding author: judyvet@jnu.ac.kr (J.H.), jop@jnu.ac.kr (J.-O.P.), and eunpyochoi@jnu.ac.kr (E.C.)","[74.0, 864.0, 1032.0, 953.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +Platform Utilizing Electromagnetic Fields","[74.0, 155.0, 1028.0, 268.0]",paper_title,0.8,"[""page-1 zone title_zone: Magnetoresponsive Stem Cell Spheroid-based Cartilage Recover""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +2,3,text,"Ami Yooa, †, Gwangjun Goa, b, †, Kim Tien Nguyena, b, Kyungmin Leea, b, Hyun-Ki Mina, Byungjeon Kanga","[74.0, 355.0, 1026.0, 445.0]",authors,0.8,"[""page-1 zone author_zone: Ami Yooa, \u2020, Gwangjun Goa, ba, †, Gwangjun Goa, b, †, Kim Tien Nguye", "found_in_fulltext": false, @@ -36,9 +36,9 @@ { "block_id": "p2:4", "page": 2, - "role": "frontmatter_support", - "zone": "body_zone", - "render_default": true, + "role": "unknown_structural", + "zone": "frontmatter_main_zone", + "render_default": false, "snippet": "a. Korea Institute of Medical Microrobotics, 43-26 Cheomdangwagi-ro, Buk-gu, Gwa", "found_in_fulltext": false, "fulltext_offset": -1 @@ -46,13 +46,33 @@ { "block_id": "p2:5", "page": 2, - "role": "frontmatter_support", - "zone": "body_zone", + "role": "affiliation", + "zone": "frontmatter_main_zone", "render_default": true, "snippet": "b. School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro", "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p2:6", + "page": 2, + "role": "frontmatter_support", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "These authors contributed equally to this work.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:7", + "page": 2, + "role": "frontmatter_support", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "*Corresponding author: judyvet@jnu.ac.kr (J.H.), jop@jnu.ac.kr (J.-O.P.), and eu", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p2:8", "page": 2, @@ -787,7 +807,7 @@ "block_id": "p25:1", "page": 25, "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "render_default": true, "snippet": "fields can provide effective potential therapeutic agents to promote the regener", "found_in_fulltext": true, @@ -796,8 +816,8 @@ { "block_id": "p25:2", "page": 25, - "role": "backmatter_heading", - "zone": "tail_nonref_hold_zone", + "role": "subsection_heading", + "zone": "frontmatter_side_zone", "render_default": true, "snippet": "Conflict of Interest", "found_in_fulltext": true, @@ -806,8 +826,8 @@ { "block_id": "p25:3", "page": 25, - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "render_default": true, "snippet": "All other authors declare that they have no competing interests.", "found_in_fulltext": true, @@ -816,8 +836,8 @@ { "block_id": "p25:4", "page": 25, - "role": "backmatter_heading", - "zone": "tail_nonref_hold_zone", + "role": "sub_subsection_heading", + "zone": "body_zone", "render_default": true, "snippet": "Acknowledgments", "found_in_fulltext": true, @@ -826,8 +846,8 @@ { "block_id": "p25:5", "page": 25, - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "render_default": true, "snippet": "A. Yoo and G. Go contributed equally to this work. We thank Medical Microrobot C", "found_in_fulltext": true, @@ -841,7 +861,7 @@ "render_default": true, "snippet": "References", "found_in_fulltext": true, - "fulltext_offset": 50524 + "fulltext_offset": 50523 }, { "block_id": "p26:2", @@ -851,7 +871,7 @@ "render_default": true, "snippet": "[1] C. Cooper, M.K. Javaid, N. Arden, Epidemiology of osteoarthritis, Atlas of o", "found_in_fulltext": true, - "fulltext_offset": 50535 + "fulltext_offset": 50534 }, { "block_id": "p26:3", @@ -861,7 +881,7 @@ "render_default": true, "snippet": "[2] P. Creamer, M. Hochberg, Why does osteoarthritis of the knee hurt--sometimes", "found_in_fulltext": true, - "fulltext_offset": 50656 + "fulltext_offset": 50655 }, { "block_id": "p26:4", @@ -871,7 +891,7 @@ "render_default": true, "snippet": "[3] L. Zhang, J. Hu, K.A. Athanasiou, The role of tissue engineering in articula", "found_in_fulltext": true, - "fulltext_offset": 50769 + "fulltext_offset": 50768 }, { "block_id": "p26:5", @@ -881,7 +901,7 @@ "render_default": true, "snippet": "[4] I. Uzieliene, P. Bernotas, A. Mobasheri, E. Bernotiene, The Role of Physical", "found_in_fulltext": true, - "fulltext_offset": 50922 + "fulltext_offset": 50921 }, { "block_id": "p26:6", @@ -891,7 +911,7 @@ "render_default": true, "snippet": "[5] E.B. Hunziker, Articular cartilage repair: basic science and clinical progre", "found_in_fulltext": true, - "fulltext_offset": 51095 + "fulltext_offset": 51094 }, { "block_id": "p26:7", @@ -901,7 +921,7 @@ "render_default": true, "snippet": "[6] C. Baugé, K. Boumédiene, Use of Adult Stem Cells for Cartilage Tissue Engine", "found_in_fulltext": true, - "fulltext_offset": 51272 + "fulltext_offset": 51271 }, { "block_id": "p26:8", @@ -911,7 +931,7 @@ "render_default": true, "snippet": "[7] A. Khademhosseini, Micro and nanoengineering of the cell microenvironment: t", "found_in_fulltext": true, - "fulltext_offset": 51435 + "fulltext_offset": 51434 }, { "block_id": "p26:9", @@ -921,7 +941,7 @@ "render_default": true, "snippet": "[8] H. Rubash, J. Berry, Revisions of hip and knee replacements in Canada, Canad", "found_in_fulltext": true, - "fulltext_offset": 51565 + "fulltext_offset": 51564 }, { "block_id": "p26:10", @@ -931,7 +951,7 @@ "render_default": true, "snippet": "[9] Y. Petrenko, E. Syková, Š. Kubinová, The therapeutic potential of three-dime", "found_in_fulltext": true, - "fulltext_offset": 51753 + "fulltext_offset": 51752 }, { "block_id": "p26:11", @@ -941,7 +961,7 @@ "render_default": true, "snippet": "[10] H. Dashtdar, H. Rothan, T. Tay, R.E. Raja Ahmad, R. Ali, L. Tay, et al., A ", "found_in_fulltext": true, - "fulltext_offset": 51931 + "fulltext_offset": 51930 }, { "block_id": "p27:1", @@ -951,7 +971,7 @@ "render_default": true, "snippet": "[11] N. Landázuri, S. Tong, J. Suo, G. Joseph, D. Weiss, D.J. Sutcliffe, et al.,", "found_in_fulltext": true, - "fulltext_offset": 52230 + "fulltext_offset": 52229 }, { "block_id": "p27:2", @@ -961,7 +981,7 @@ "render_default": true, "snippet": "[12] G. Go, J. Han, J. Zhen, S. Zheng, A. Yoo, M.-J. Jeon, et al., A Magneticall", "found_in_fulltext": true, - "fulltext_offset": 52448 + "fulltext_offset": 52447 }, { "block_id": "p27:3", @@ -971,7 +991,7 @@ "render_default": true, "snippet": "[13] S. Jeon, S. Kim, S. Ha, S. Lee, E. Kim, S.Y. Kim, et al., Magnetically actu", "found_in_fulltext": true, - "fulltext_offset": 52667 + "fulltext_offset": 52666 }, { "block_id": "p27:4", @@ -981,7 +1001,7 @@ "render_default": true, "snippet": "[14] M. van der Elst, C.P.A.T. Klein, J.M. de Blieck-Hogervorst, P. Patka, H.J.T", "found_in_fulltext": true, - "fulltext_offset": 52845 + "fulltext_offset": 52844 }, { "block_id": "p27:5", @@ -991,7 +1011,7 @@ "render_default": true, "snippet": "[15] M. J Martin, A. Muotri, F. Gage, A. Varki, Human embryonic stem cells expre", "found_in_fulltext": true, - "fulltext_offset": 53102 + "fulltext_offset": 53101 }, { "block_id": "p27:6", @@ -1001,7 +1021,7 @@ "render_default": true, "snippet": "[16] W. Mueller-Klieser, Three-dimensional cell cultures: From molecular mechani", "found_in_fulltext": true, - "fulltext_offset": 53226 + "fulltext_offset": 53225 }, { "block_id": "p27:7", @@ -1011,7 +1031,7 @@ "render_default": true, "snippet": "[17] D. Ciombor, G. Lester, R. Aaron, P. Neame, B. Caterson, Low Frequency EMF R", "found_in_fulltext": true, - "fulltext_offset": 53341 + "fulltext_offset": 53340 }, { "block_id": "p27:8", @@ -1021,7 +1041,7 @@ "render_default": true, "snippet": "[18] S. Mayer-Wagner, A. Passberger, B. Sievers, J. Aigner, B. Summer, T.S. Schi", "found_in_fulltext": true, - "fulltext_offset": 53498 + "fulltext_offset": 53497 }, { "block_id": "p27:9", @@ -1031,7 +1051,7 @@ "render_default": true, "snippet": "[19] J. Nowak, F. Wiekhorst, L. Trahms, S. Odenbach, The influence of hydrodynam", "found_in_fulltext": true, - "fulltext_offset": 53749 + "fulltext_offset": 53748 }, { "block_id": "p28:1", @@ -1041,7 +1061,7 @@ "render_default": true, "snippet": "[20] M. Kallumadil, M. Tada, T. Nakagawa, M. Abe, P. Southern, Q.A. Pankhurst, S", "found_in_fulltext": true, - "fulltext_offset": 53993 + "fulltext_offset": 53992 }, { "block_id": "p28:2", @@ -1051,7 +1071,7 @@ "render_default": true, "snippet": "[21] C. Ross, Mechanisms of extra low frequency electromagnetic field (ELF-EMF) ", "found_in_fulltext": true, - "fulltext_offset": 54198 + "fulltext_offset": 54197 }, { "block_id": "p28:3", @@ -1061,7 +1081,7 @@ "render_default": true, "snippet": "[22] J.E. Henrietta, M.-J.M. Eileen, ON THE VISCOSITY AND pH OF SYNOVIAL FLUID A", "found_in_fulltext": true, - "fulltext_offset": 54375 + "fulltext_offset": 54374 }, { "block_id": "p28:4", @@ -1071,7 +1091,7 @@ "render_default": true, "snippet": "[23] D. Choudhury, R. Walker, T. Roy, S. Paul, R. Mootanah, Performance of honed", "found_in_fulltext": true, - "fulltext_offset": 54549 + "fulltext_offset": 54548 }, { "block_id": "p28:5", @@ -1081,7 +1101,7 @@ "render_default": true, "snippet": "[24] C.J. Centeno, D. Busse, J. Kisiday, C. Keohan, M. Freeman, Increased knee c", "found_in_fulltext": true, - "fulltext_offset": 54709 + "fulltext_offset": 54708 }, { "block_id": "p28:6", @@ -1091,7 +1111,7 @@ "render_default": true, "snippet": "[25] U. Nöth, A.F. Steinert, R.S. Tuan, Technology Insight: adult mesenchymal st", "found_in_fulltext": true, - "fulltext_offset": 54941 + "fulltext_offset": 54940 }, { "block_id": "p28:7", @@ -1101,7 +1121,7 @@ "render_default": true, "snippet": "[26] http://www.medi-post.com/front/eng/stemcell/cartistem.do.", "found_in_fulltext": true, - "fulltext_offset": 55110 + "fulltext_offset": 55109 }, { "block_id": "p28:8", @@ -1111,7 +1131,7 @@ "render_default": true, "snippet": "[27] G. Kamei, T. Kobayashi, S. Ohkawa, W. Kongcharoensombat, N. Adachi, K. Taka", "found_in_fulltext": true, - "fulltext_offset": 55173 + "fulltext_offset": 55172 }, { "block_id": "p28:9", @@ -1121,7 +1141,7 @@ "render_default": true, "snippet": "[28] E.E. Mahmoud, G. Kamei, Y. Harada, R. Shimizu, N. Kamei, N. Adachi, et al.,", "found_in_fulltext": true, - "fulltext_offset": 55391 + "fulltext_offset": 55390 }, { "block_id": "p28:10", @@ -1131,7 +1151,7 @@ "render_default": true, "snippet": "[29] P.R. Baraniak, T.C. McDevitt, Scaffold-free culture of mesenchymal stem cel", "found_in_fulltext": true, - "fulltext_offset": 55612 + "fulltext_offset": 55611 }, { "block_id": "p29:1", @@ -1141,7 +1161,7 @@ "render_default": true, "snippet": "[30] Y. Yamaguchi, J. Ohno, A. Sato, H. Kido, T. Fukushima, Mesenchymal stem cel", "found_in_fulltext": true, - "fulltext_offset": 55804 + "fulltext_offset": 55803 }, { "block_id": "p29:2", @@ -1151,7 +1171,7 @@ "render_default": true, "snippet": "[31] U. De Simone, M. Roccio, L. Gribaldo, A. 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Gazeau, Universal cell labelling with anionic magnetic nanop", "found_in_fulltext": true, - "fulltext_offset": 56787 + "fulltext_offset": 56786 }, { "block_id": "p29:7", @@ -1201,7 +1221,7 @@ "render_default": true, "snippet": "[36] S. Salatin, A. Yari Khosroushahi, Overviews on the cellular uptake mechanis", "found_in_fulltext": true, - "fulltext_offset": 56909 + "fulltext_offset": 56908 }, { "block_id": "p29:8", @@ -1211,7 +1231,7 @@ "render_default": true, "snippet": "[37] K. Andreas, R. Georgieva, M. Ladwig, S. Mueller, M. Notter, M. Sittinger, e", "found_in_fulltext": true, - "fulltext_offset": 57096 + "fulltext_offset": 57095 }, { "block_id": "p29:9", @@ -1221,7 +1241,7 @@ "render_default": true, "snippet": "[38] G.n. Jutz, P. van Rijn, B. Santos Miranda, A. Böker, Ferritin: a versatile ", "found_in_fulltext": true, - "fulltext_offset": 57341 + "fulltext_offset": 57340 }, { "block_id": "p29:10", @@ -1231,7 +1251,7 @@ "render_default": true, "snippet": "[39] S. Sharifi, S. 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Lagarde, V.-A. Maraloiu, M.-G. Blanchin, F. Gendron, C. Wilhelm", "found_in_fulltext": true, - "fulltext_offset": 58344 + "fulltext_offset": 58343 }, { "block_id": "p30:5", @@ -1281,7 +1301,7 @@ "render_default": true, "snippet": "[44] T. Skotland, P.C. Sontum, I. Oulie, In vitro stability analyses as a model ", "found_in_fulltext": true, - "fulltext_offset": 58616 + "fulltext_offset": 58615 }, { "block_id": "p30:6", @@ -1291,7 +1311,7 @@ "render_default": true, "snippet": "[45] F. Mazuel, A. Espinosa, N. Luciani, M. Reffay, R. Le Borgne, L. Motte, et a", "found_in_fulltext": true, - "fulltext_offset": 58868 + "fulltext_offset": 58867 }, { "block_id": "p30:7", @@ -1301,7 +1321,7 @@ "render_default": true, "snippet": "[46] Y.-K. Chang, Y.-P. Liu, J. H Ho, S.-C. Hsu, O. Lee, Amine-surface-modified ", "found_in_fulltext": true, - "fulltext_offset": 59106 + "fulltext_offset": 59105 }, { "block_id": "p30:8", @@ -1311,7 +1331,7 @@ "render_default": true, "snippet": "[47] A. Heymer, D. 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Lin, Y.-C. Fu, C.K. Wang, S.-C. Wu, G.-J. Wang, et al., E", "found_in_fulltext": true, - "fulltext_offset": 60938 + "fulltext_offset": 60937 }, { "block_id": "p31:9", @@ -1401,7 +1421,7 @@ "render_default": true, "snippet": "[56] S. Muramatsu, M. Wakabayashi, T. Ohno, K. Amano, R. Ooishi, T. Sugahara, et", "found_in_fulltext": true, - "fulltext_offset": 61148 + "fulltext_offset": 61147 }, { "block_id": "p31:10", @@ -1411,7 +1431,7 @@ "render_default": true, "snippet": "[57] F. Torossian, A. Bisson, J.-P. Vannier, O. Boyer, M. Lamacz, TRPC expressio", "found_in_fulltext": true, - "fulltext_offset": 61336 + "fulltext_offset": 61335 }, { "block_id": "p32:1", @@ -1421,17 +1441,17 @@ "render_default": true, "snippet": "[58] R.G. LeBaron, K.A. Athanasiou, Ex vivo synthesis of articular cartilage, Bi", "found_in_fulltext": true, - "fulltext_offset": 63556 + "fulltext_offset": 61481 }, { "block_id": "p32:2", "page": 32, - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "post_reference_backmatter_zone", "render_default": true, "snippet": "Biographies", "found_in_fulltext": true, - "fulltext_offset": 61468 + "fulltext_offset": 61467 }, { "block_id": "p32:3", @@ -1441,7 +1461,7 @@ "render_default": true, "snippet": "Amr Yoo received her B.S. (2010) degrees from the Dep. of Applied Bioscience and", "found_in_fulltext": true, - "fulltext_offset": 61482 + "fulltext_offset": 61591 }, { "block_id": "p32:4", @@ -1451,7 +1471,7 @@ "render_default": true, "snippet": "Gwangjun Go received his B.S. (2013) and M.S. 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(a) Experimental setup of", "found_in_fulltext": true, - "fulltext_offset": 49505 - }, - { - "block_id": "p41:1", - "page": 41, - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", - "render_default": false, - "snippet": "(a)", - "found_in_fulltext": true, - "fulltext_offset": 49560 - }, - { - "block_id": "p41:3", - "page": 41, - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", - "render_default": false, - "snippet": "(b)", - "found_in_fulltext": true, - "fulltext_offset": 49602 - }, - { - "block_id": "p41:5", - "page": 41, - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", - "render_default": false, - "snippet": "(c)", - "found_in_fulltext": true, - "fulltext_offset": 49712 - }, - { - "block_id": "p41:7", - "page": 41, - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", - "render_default": false, - "snippet": "(d)", - "found_in_fulltext": true, - "fulltext_offset": 23424 - }, - { - "block_id": "p41:10", - "page": 41, - "role": "figure_caption_candidate", - "zone": "post_reference_backmatter_zone", - "render_default": false, - "snippet": "(e)", - "found_in_fulltext": true, - "fulltext_offset": 50068 + "fulltext_offset": 49437 }, { "block_id": "p41:13", diff --git a/audit/DWQQK2YB/page_risk_summary.json b/audit/DWQQK2YB/page_risk_summary.json index 84065347..1088f73f 100644 --- a/audit/DWQQK2YB/page_risk_summary.json +++ b/audit/DWQQK2YB/page_risk_summary.json @@ -420,18 +420,13 @@ }, { "page": 25, - "risk_score": 4, - "risk_reasons": [ - "same_page_boundary" - ], - "recommended_audit_targets": [ - "reading_order", - "same_page_boundary" - ], + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { - "body_paragraph": 1, + "body_paragraph": 3, "reference_item": 0, - "tail_like": 5, + "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, @@ -561,7 +556,7 @@ "counts": { "body_paragraph": 0, "reference_item": 0, - "tail_like": 7, + "tail_like": 6, "media_assets": 0, "table_like": 0, "captions": 0, @@ -609,20 +604,24 @@ }, { "page": 35, - "risk_score": 0, - "risk_reasons": [], - "recommended_audit_targets": [], + "risk_score": 3, + "risk_reasons": [ + "reader_object_gap" + ], + "recommended_audit_targets": [ + "object_ownership" + ], "counts": { "body_paragraph": 0, "reference_item": 0, - "tail_like": 1, + "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 3, "hold": 0, "unknown_structural": 0, "matched_figures": 0, - "ambiguous_figures": 0 + "ambiguous_figures": 1 } }, { @@ -645,9 +644,8 @@ }, { "page": 37, - "risk_score": 6, + "risk_score": 3, "risk_reasons": [ - "caption_asset_mismatch", "reader_object_gap" ], "recommended_audit_targets": [ @@ -659,7 +657,7 @@ "tail_like": 0, "media_assets": 1, "table_like": 0, - "captions": 3, + "captions": 1, "hold": 0, "unknown_structural": 0, "matched_figures": 1, @@ -683,7 +681,7 @@ "tail_like": 0, "media_assets": 19, "table_like": 0, - "captions": 12, + "captions": 6, "hold": 0, "unknown_structural": 0, "matched_figures": 1, @@ -707,7 +705,7 @@ "tail_like": 0, "media_assets": 10, "table_like": 0, - "captions": 9, + "captions": 1, "hold": 0, "unknown_structural": 0, "matched_figures": 0, @@ -716,13 +714,9 @@ }, { "page": 40, - "risk_score": 3, - "risk_reasons": [ - "reader_object_gap" - ], - "recommended_audit_targets": [ - "object_ownership" - ], + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { "body_paragraph": 0, "reference_item": 0, @@ -733,7 +727,7 @@ "hold": 0, "unknown_structural": 0, "matched_figures": 0, - "ambiguous_figures": 1 + "ambiguous_figures": 0 } }, { @@ -753,7 +747,7 @@ "tail_like": 0, "media_assets": 7, "table_like": 0, - "captions": 6, + "captions": 1, "hold": 0, "unknown_structural": 0, "matched_figures": 1, @@ -781,12 +775,11 @@ ], "selected_pages": [ 2, - 25, 26, + 35, 37, 38, 39, - 40, 41 ] } \ No newline at end of file diff --git a/audit/DWQQK2YB/reference_intrusion_candidates.json b/audit/DWQQK2YB/reference_intrusion_candidates.json index 4c1aee36..39bd02da 100644 --- a/audit/DWQQK2YB/reference_intrusion_candidates.json +++ b/audit/DWQQK2YB/reference_intrusion_candidates.json @@ -440,20 +440,6 @@ "role": "reference_item", "zone": "reference_zone", "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p32:0", - "page": 32, - "role": "frontmatter_noise", - "zone": "preproof_cover_zone", - "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p32:1", - "page": 32, - "role": "backmatter_body", - "zone": "post_reference_backmatter_zone", - "reason": "logical_order_between_reference_members" } ] } \ No newline at end of file diff --git a/audit/DWQQK2YB/reference_span_audit.json b/audit/DWQQK2YB/reference_span_audit.json index a47c6917..c86af4a2 100644 --- a/audit/DWQQK2YB/reference_span_audit.json +++ b/audit/DWQQK2YB/reference_span_audit.json @@ -9,10 +9,10 @@ "block_id": "p26:1" }, "end": { - "page": 32, + "page": 31, "column": 1, - "y": 99.0, - "block_id": "p32:1" + "y": 1369.0, + "block_id": "p31:10" }, "heading_block_id": "p26:1", "ordered_block_ids": [ @@ -73,8 +73,7 @@ "p31:7", "p31:8", "p31:9", - "p31:10", - "p32:1" + "p31:10" ], "inside_block_ids": [ "p26:1", @@ -134,12 +133,11 @@ "p31:7", "p31:8", "p31:9", - "p31:10", - "p32:1" + "p31:10" ], "explicitly_outside_nearby_block_ids": [ "p26:0", - "p32:2" + "p32:0" ], "intrusion_candidates": [ { @@ -582,20 +580,6 @@ "role": "reference_item", "zone": "reference_zone", "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p32:0", - "page": 32, - "role": "frontmatter_noise", - "zone": "preproof_cover_zone", - "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p32:1", - "page": 32, - "role": "backmatter_body", - "zone": "post_reference_backmatter_zone", - "reason": "logical_order_between_reference_members" } ] } diff --git a/audit/GTRPMM56/audit_report.json b/audit/GTRPMM56/audit_report.json index 75bda307..6796d7c3 100644 --- a/audit/GTRPMM56/audit_report.json +++ b/audit/GTRPMM56/audit_report.json @@ -5,35 +5,35 @@ "focus": [], "artifact_fingerprint": { "result_json_hash": "sha256:877d7ad7b153abd9c8eacd61ccb140b0da7caa16652226c56c5fa4442ab4aa01", - "meta_json_hash": "sha256:e01f201d87d53142f38d64f91f0c1954282293980011788202d60cf4e9d3e0f4", - "blocks_raw_hash": "sha256:a45237d48a879aa58853c17493006fac1f5227f6492b50dd0c135c016b8f2e4e", - "structured_blocks_hash": "sha256:93dbdc48690af90c8e28622b3f0aea7599adeb3da3af7e356057401c96c23b08", - "document_structure_hash": "sha256:839d002217d2f424434662b04e7b281bf8f6c99496130f6c1e7560967006fa35", - "figure_inventory_hash": "sha256:9993d326fbd51ac5c40097c2cc641f9942a49f25f73563188ba8726d710a666b", - "table_inventory_hash": "sha256:598767804b53212ac7a6960bd1c55d3e45bc28befcaed9c8e1403508c2e46825", - "reader_figures_hash": "sha256:8ee2742e5775a2d20d2b972c0e717393ecbc3b7ca49f655ec22d616e221868c3", - 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+ "p18:46", + "p18:47" ], "findings": [ { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:11" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:12" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:13" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:14" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:15" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:16" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:17" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:18" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:19" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:20" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:21" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:22" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:23" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:0" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:1" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:2" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:3" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:4" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:5" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:6" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "frontmatter_error", + "category": "same_page_boundary_error", "severity": "major", "block_ids": [], - "truth": "page 1 should have clearer frontmatter role resolution", - "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", - "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", "evidence": { - "annotated_page": "annotated_pages/page_001.png", + "annotated_page": "annotated_pages/page_014.png", "artifact": "page_risk_summary.json" } }, @@ -535,7 +304,7 @@ "pipeline_behavior": "page contains mixed body/reference/tail signals", "root_cause_hypothesis": "same-page boundary ambiguity", "evidence": { - "annotated_page": "annotated_pages/page_014.png", + "annotated_page": "annotated_pages/page_018.png", "artifact": "page_risk_summary.json" } }, @@ -563,18 +332,18 @@ "p1:8", "p1:9", "p2:0", + "p2:1", "p2:2", "p3:0", "p3:3", "p4:0", + "p4:1", + "p4:2", "p4:11", "p5:0", "p5:3", "p6:0", - "p7:0", - "p8:0", - "p8:3", - "p9:0" + "p6:1" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/GTRPMM56/audit_report.md b/audit/GTRPMM56/audit_report.md index 886ce79f..28a6b952 100644 --- a/audit/GTRPMM56/audit_report.md +++ b/audit/GTRPMM56/audit_report.md @@ -2,32 +2,12 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [1, 3, 5, 7, 8, 9, 10, 11, 12, 13, 14] -- Reviewed blocks: 154 +- Reviewed pages: [1, 3, 5, 7, 8, 9, 10, 11, 12, 13, 14, 18] +- Reviewed blocks: 202 ## Findings -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output diff --git a/audit/GTRPMM56/audit_scope.json b/audit/GTRPMM56/audit_scope.json index 3b8d5b8b..afa764e4 100644 --- a/audit/GTRPMM56/audit_scope.json +++ b/audit/GTRPMM56/audit_scope.json @@ -11,7 +11,8 @@ 11, 12, 13, - 14 + 14, + 18 ], "required_block_ids": [ "p1:0", @@ -27,22 +28,15 @@ "p1:10", "p3:1", "p3:3", - "p3:7", "p5:1", "p5:3", - "p5:5", "p7:0", "p7:1", - "p7:8", "p8:1", "p8:3", - "p9:4", "p9:6", - "p10:1", "p10:2", - "p11:1", "p11:2", - "p11:9", "p12:0", "p12:1", "p12:2", @@ -96,7 +90,6 @@ "p13:34", "p14:3", "p14:4", - "p14:5", "p14:9", "p14:11", "p14:12", @@ -109,7 +102,52 @@ "p14:19", "p14:20", "p14:21", - "p14:22" + "p14:22", + "p18:1", + "p18:2", + "p18:3", + "p18:4", + "p18:5", + "p18:6", + "p18:7", + "p18:8", + "p18:9", + "p18:10", + "p18:11", + "p18:12", + "p18:13", + "p18:14", + "p18:15", + "p18:16", + "p18:17", + "p18:18", + "p18:19", + "p18:20", + "p18:21", + "p18:22", + "p18:23", + "p18:24", + "p18:25", + "p18:26", + "p18:27", + "p18:28", + "p18:29", + "p18:30", + "p18:31", + "p18:32", + "p18:33", + "p18:34", + "p18:35", + "p18:36", + "p18:37", + "p18:38", + "p18:39", + "p18:40", + "p18:41", + "p18:42", + "p18:43", + "p18:44", + "p18:45" ], "required_blocks": [ { @@ -192,8 +230,7 @@ "block_id": "p1:5", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -310,21 +347,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p3:7", - "page": 3, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:1", "page": 5, @@ -355,21 +377,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:5", - "page": 5, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:0", "page": 7, @@ -400,21 +407,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p7:8", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p8:1", "page": 8, @@ -445,21 +437,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p9:4", - "page": 9, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p9:6", "page": 9, @@ -475,21 +452,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p10:1", - "page": 10, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p10:2", "page": 10, @@ -505,21 +467,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:1", - "page": 11, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:2", "page": 11, @@ -535,21 +482,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:9", - "page": 11, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p12:0", "page": 12, @@ -1073,8 +1005,7 @@ "block_id": "p13:18", "page": 13, "required_reason": [ - "backmatter", - "needs_resolution" + "backmatter" ], "minimum_fields": [ "block_id", @@ -1355,21 +1286,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p14:5", - "page": 14, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p14:9", "page": 14, @@ -1565,6 +1481,683 @@ "truth_zone", "truth_reference_membership" ] + }, + { + "block_id": "p18:1", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:2", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:3", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:4", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:5", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:6", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:7", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:8", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:9", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:10", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:11", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:12", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:13", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:14", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:15", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:16", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:17", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:18", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:19", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:20", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:21", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:22", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:23", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:24", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:25", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:26", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:27", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:28", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:29", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:30", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:31", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:32", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:33", + "page": 18, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:34", + "page": 18, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:35", + "page": 18, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:36", + "page": 18, + "required_reason": [ + "backmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:37", + "page": 18, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:38", + "page": 18, + "required_reason": [ + "backmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:39", + "page": 18, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:40", + "page": 18, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:41", + "page": 18, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p18:42", + "page": 18, + "required_reason": [ + "backmatter" + ], + 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"body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -3106,7 +3106,7 @@ "block_id": "p13:18", "page": 13, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 875.0, @@ -3546,8 +3546,8 @@ "block_id": "p14:5", "page": 14, "raw_label": "text", - "role": "unknown_structural", - "zone": "", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 605.0, 223.0, @@ -8746,8 +8746,8 @@ "block_id": "p18:34", "page": 18, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "", + "role": "sub_subsection_heading", + "zone": "tail_nonref_hold_zone", "bbox": [ 609.0, 589.0, @@ -8786,8 +8786,8 @@ "block_id": "p18:36", "page": 18, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "", + "role": "unknown_structural", + "zone": "tail_nonref_hold_zone", "bbox": [ 609.0, 782.0, @@ -8806,7 +8806,7 @@ "block_id": "p18:37", "page": 18, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 608.0, @@ -8826,8 +8826,8 @@ "block_id": "p18:38", "page": 18, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "", + "role": "unknown_structural", + "zone": "tail_nonref_hold_zone", "bbox": [ 610.0, 863.0, @@ -8846,7 +8846,7 @@ "block_id": "p18:39", "page": 18, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 610.0, diff --git a/audit/GTRPMM56/block_trace.csv b/audit/GTRPMM56/block_trace.csv index 05046a87..19e1da65 100644 --- a/audit/GTRPMM56/block_trace.csv +++ b/audit/GTRPMM56/block_trace.csv @@ -3,8 +3,8 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,1,header,https://doi.org/10.1038/s41584-025-01236-7,"[782.0, 80.0, 1125.0, 105.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,2,header,Check for updates,"[957.0, 184.0, 1126.0, 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Sections
Introduction
The anisotropic nature of articular cartilage
Collagen type II fibres in the articular cartilage matrix
ProteinFunctionInteraction with ECM componentsRefs.
Proteoglycans
VersicanA large bottlebrush chondroit","[75.0, 275.0, 1123.0, 1491.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 10,3,footer,Nature Reviews Rheumatology,"[75.0, 1523.0, 311.0, 1544.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 11,0,paragraph_title,Review article,"[77.0, 80.0, 308.0, 115.0]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False -11,1,figure_title,Table 1 (continued) | The function of articular cartilage proteoglycans and (glyco)proteins and their interactions with extracellular matrix (ECM) components,"[78.0, 222.0, 1057.0, 268.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 1 (continued) | The function of articular cartilage pr""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,1,figure_title,Table 1 (continued) | The function of articular cartilage proteoglycans and (glyco)proteins and their interactions with extracellular matrix (ECM) components,"[78.0, 222.0, 1057.0, 268.0]",table_caption,0.9,"[""table prefix matched: Table 1 (continued) | The function of articular cartilage pr""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 11,2,table,"
ProteinFunctionInteraction with ECM componentsRefs.
Other (glyco)proteins (continued)
ElastinA protein ","[77.0, 279.0, 1123.0, 667.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 11,3,vision_footnote,"Indicates small leucine-rich proteoglycans. BMP, bone morphogenetic protein; COMP, cartilage oligomeric matrix protein; ECM, extracellular matrix; FGF, fibroblast growth factor; GAG, glycosaminoglycan","[74.0, 673.0, 1077.0, 705.0]",footnote,0.7,"[""vision_footnote label: Indicates small leucine-rich proteoglycans. BMP, bone morpho""]",footnote,0.7,body_zone,body_like,none,True,True 11,4,text,"cartilage and can remain stable in vivo, as demonstrated in horses, in which implants remained stable for 6 months $ ^{167} $. However, this approach is only temporary as PCL is biodegradable and so w","[73.0, 739.0, 594.0, 915.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -116,7 +128,9 @@ Once skeletal maturity occurs, the collagen matrix cannot be further replaced $ 11,6,text,"The anisotropic organization of the ECM, particularly the alignment of collagen fibres, is essential not only for the mechanical performance of cartilage tissue $ ^{173} $ but also for other tissues, ","[73.0, 955.0, 594.0, 1409.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,7,paragraph_title,Approaches to inducing collagen alignment,"[74.0, 1427.0, 443.0, 1449.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Approaches to inducing collagen alignment""]",subsection_heading,0.6,body_zone,body_like,none,True,True 11,8,text,"For collagen type I, alignment can be achieved with fluid flow-induced shear forces, which induce collagen monomer orientation along the flow direction $ ^{182-186} $. Alternatively, tension-based met","[73.0, 1449.0, 594.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,9,text,,"[605.0, 737.0, 1128.0, 1343.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +11,9,text,"flow direction182–186. Alternatively, tension-based methods187,188 (such as +dip-pen nanolithography189, which relies on fibre stretching), can be +used to self-assemble the collagen monomers into netwo","[605.0, 737.0, 1128.0, 1343.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,10,text,"The application of these alignment techniques has not yet been explored for collagen type II fibres. In vivo, collagen type II fibres are thinner than collagen type I fibres, with less crystallinity a","[605.0, 1341.0, 1128.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,11,footer,Nature Reviews Rheumatology,"[76.0, 1523.0, 310.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 12,0,paragraph_title,Review article,"[77.0, 81.0, 307.0, 117.0]",noise,0.8,"[""running header: review article""]",noise,0.8,tail_nonref_hold_zone,heading_like,short_fragment,False,False @@ -165,7 +179,8 @@ A state of matter with properties between those of a liquid and a solid crystal, 13,17,text,"A high concentration of macromolecules in a confined space that influences molecular interactions and assembly. Nascent Newly formed or immature.","[608.0, 1178.0, 860.0, 1258.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -13,18,text,,"[875.0, 288.0, 1048.0, 334.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +13,18,text,"Nascent +Newly formed or immature.","[875.0, 288.0, 1048.0, 334.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 13,19,text,"Non-reducible crosslinks A non-reversible chemical bond that permanently stabilizes collagen fibrils.","[874.0, 352.0, 1111.0, 420.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 13,20,paragraph_title,Nucleator,"[875.0, 438.0, 962.0, 460.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Nucleator""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True @@ -197,7 +212,9 @@ networks.","[875.0, 953.0, 1113.0, 1043.0]",body_paragraph,0.6,"[""default body_ 14,2,paragraph_title,Challenges and considerations,"[74.0, 522.0, 397.0, 546.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Challenges and considerations""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 14,3,text,"This Review explores the basic biology of articular cartilage, from its cellular and ECM composition in adult tissue to postnatal development that gives rise to the complex tissue architecture. We emp","[73.0, 546.0, 594.0, 1041.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 14,4,text,Several knowledge gaps remain. Current literature focuses mainly on inducing chondrogenic differentiation for ECM production (both in cell and/or hydrogel-based therapies and in laboratory-grown impla,"[73.0, 1043.0, 594.0, 1496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -14,5,text,,"[605.0, 223.0, 1126.0, 331.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True +14,5,text,"of bioactive stimuli that drive ECM organization, such as mechanical +loading, bottom–up tissue growth, collagen fibrillogenesis and fibre +crosslinking, could lead to the development of tissues with th","[605.0, 223.0, 1126.0, 331.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,6,text,"Although this Review focused mainly on structural aspects, it is also important to consider the inflammatory environment that is often present at sites of cartilage defect, especially in OA and trauma","[605.0, 332.0, 1127.0, 569.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,7,paragraph_title,Conclusion,"[608.0, 587.0, 733.0, 610.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True 14,8,text,"As the field of tissue engineering advances, new approaches to chondral implants and collagen guidance will continue to emerge, enabling the development of more biomimetic constructs. By replicating t","[605.0, 610.0, 1128.0, 935.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -457,17 +474,17 @@ networks.","[875.0, 953.0, 1113.0, 1043.0]",body_paragraph,0.6,"[""default body_ 18,31,reference_content,"245. Sun, Y., Wang, T. L., Toh, W. S. & Pei, M. The role of laminins in cartilaginous tissues: from development to regeneration. Eur. Cell Mater. 34, 40 (2017).","[611.0, 448.0, 1090.0, 480.0]",reference_item,0.85,"[""reference content label: 245. Sun, Y., Wang, T. L., Toh, W. S. & Pei, M. The role of ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 18,32,reference_content,"246. Schminke, B., Frese, J., Bode, C., Goldring, M. B. & Miosge, N. Laminins and nidogens in the pericellular matrix of chondrocytes: their role in osteoarthritis and chondrogenic differentiation. Am","[611.0, 481.0, 1114.0, 526.0]",reference_item,0.85,"[""reference content label: 246. Schminke, B., Frese, J., Bode, C., Goldring, M. B. & Mi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 18,33,reference_content,"247. Batsalova, T. & Dzhambazov, B. Significance of type II collagen posttranslational modifications: from autoantigenesis to improved diagnosis and treatment of rheumatoid arthritis. Int. J. Mol. Sci","[610.0, 529.0, 1123.0, 575.0]",reference_item,0.85,"[""reference content label: 247. Batsalova, T. & Dzhambazov, B. Significance of type II ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True -18,34,paragraph_title,Acknowledgements,"[609.0, 589.0, 766.0, 607.0]",backmatter_heading,0.8,"[""backmatter heading on page 18: Acknowledgements""]",backmatter_heading_candidate,0.8,,unknown_like,short_fragment,True,True +18,34,paragraph_title,Acknowledgements,"[609.0, 589.0, 766.0, 607.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True 18,35,text,"A.P.M., M.d.R., K.I. and J.M. would like to acknowledge the support of the Dutch Research Council (NWO), project LS-NeoCarE (NWA1389.20.192) and the Gravitation Program ""Materials Driven Regeneration""","[607.0, 608.0, 1125.0, 769.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -18,36,paragraph_title,Author contributions,"[609.0, 782.0, 772.0, 799.0]",backmatter_heading,0.8,"[""backmatter heading on page 18: Author contributions""]",backmatter_heading_candidate,0.8,,support_like,none,True,True -18,37,text,"A.P.M. researched data for the article. A.P.M., J.M. and M.d.R. wrote the article. All authors contributed substantially to discussion of the content and reviewed and/or edited the manuscript before s","[608.0, 800.0, 1097.0, 849.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -18,38,paragraph_title,Competing interests,"[610.0, 863.0, 769.0, 880.0]",backmatter_heading,0.8,"[""backmatter heading on page 18: Competing interests""]",backmatter_heading_candidate,0.8,,unknown_like,short_fragment,True,True -18,39,text,The authors declare no competing interests.,"[610.0, 882.0, 854.0, 896.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,36,paragraph_title,Author contributions,"[609.0, 782.0, 772.0, 799.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True +18,37,text,"A.P.M. researched data for the article. A.P.M., J.M. and M.d.R. wrote the article. 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work.","[608.0, 976.0, 1112.0, 1010.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 18,43,text,Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[608.0, 1024.0, 1084.0, 1057.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True -18,44,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[608.0, 1071.0, 1103.0, 1137.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -18,45,text,© Springer Nature Limited 2025,"[610.0, 1151.0, 788.0, 1169.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,44,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[608.0, 1071.0, 1103.0, 1137.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,45,text,© Springer Nature Limited 2025,"[610.0, 1151.0, 788.0, 1169.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 18,46,footnote,"Regenerative Medicine Center Utrecht, Utrecht, the Netherlands. $ ^{2} $Department of Orthopedics, 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Se", - "found_in_fulltext": true, - "fulltext_offset": 11695 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:2", @@ -350,8 +370,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Chondroprogenitor cells that are present at the surface of the nascent joint con", - "found_in_fulltext": true, - "fulltext_offset": 12521 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:3", @@ -361,7 +381,7 @@ "render_default": true, "snippet": "Some daughter cells will halt hypertrophy as they migrate downwards and retain a", "found_in_fulltext": true, - "fulltext_offset": 13266 + "fulltext_offset": 10940 }, { "block_id": "p4:4", @@ -371,7 +391,7 @@ "render_default": true, "snippet": "Collagen type II fibres in the articular cartilage matrix", "found_in_fulltext": true, - "fulltext_offset": 14015 + "fulltext_offset": 11689 }, { "block_id": "p4:5", @@ -381,7 +401,7 @@ "render_default": true, "snippet": "Collagen is present in the articular ECM in the form of heterotypic fibres; typi", "found_in_fulltext": true, - "fulltext_offset": 14073 + "fulltext_offset": 11747 }, { "block_id": "p4:6", @@ -391,7 +411,7 @@ "render_default": true, "snippet": "Collagen biosynthesis", "found_in_fulltext": true, - "fulltext_offset": 14645 + "fulltext_offset": 12319 }, { "block_id": "p4:7", @@ -401,7 +421,17 @@ "render_default": true, "snippet": "Collagen type II biosynthesis begins with the transcription of the COL2A1 gene i", "found_in_fulltext": true, - "fulltext_offset": 15020 + "fulltext_offset": 12694 + }, + { + "block_id": "p4:8", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Collagen IIB is synthesized by adult chondrocytes and is the major form of colla", + "found_in_fulltext": true, + "fulltext_offset": 13197 }, { "block_id": "p4:9", @@ -411,7 +441,7 @@ "render_default": true, "snippet": "Fibrillogenesis and self-assembly", "found_in_fulltext": true, - "fulltext_offset": 16656 + "fulltext_offset": 15437 }, { "block_id": "p4:10", @@ -421,7 +451,7 @@ "render_default": true, "snippet": "Fibrillogenesis is a step-by-step process that begins when chondrocytes release ", "found_in_fulltext": true, - "fulltext_offset": 16690 + "fulltext_offset": 15471 }, { "block_id": "p4:11", @@ -471,7 +501,17 @@ "render_default": true, "snippet": "Cartilage collagen is further interconnected by crosslinking, which is mostly fa", "found_in_fulltext": true, - "fulltext_offset": 19596 + "fulltext_offset": 18377 + }, + { + "block_id": "p5:5", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "with aging89. 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Notably, colla", + "found_in_fulltext": true, + "fulltext_offset": 22157 }, { "block_id": "p6:7", @@ -551,7 +601,7 @@ "render_default": true, "snippet": "Collagen network formation in the superficial zone", "found_in_fulltext": true, - "fulltext_offset": 25261 + "fulltext_offset": 24207 }, { "block_id": "p6:8", @@ -561,7 +611,7 @@ "render_default": true, "snippet": "I tightly packed, tangentially oriented collagen fibres provide crucial support ", "found_in_fulltext": true, - "fulltext_offset": 25312 + "fulltext_offset": 24258 }, { "block_id": "p6:9", @@ -571,7 +621,7 @@ "render_default": true, "snippet": "Overall, newly synthesized collagen fibrils are dispersed in the surrounding ECM", "found_in_fulltext": true, - "fulltext_offset": 27256 + "fulltext_offset": 26202 }, { "block_id": "p6:10", @@ -601,7 +651,7 @@ "render_default": true, "snippet": "Additionally, increasing mechanical load promotes the alignment of collagen fibr", "found_in_fulltext": true, - "fulltext_offset": 28349 + "fulltext_offset": 27295 }, { "block_id": "p7:4", @@ -611,7 +661,7 @@ "render_default": true, "snippet": "tangential strains that could potentially pull the collagen fibres parallel to i", "found_in_fulltext": true, - "fulltext_offset": 28826 + "fulltext_offset": 27772 }, { "block_id": "p7:5", @@ -621,7 +671,7 @@ "render_default": true, "snippet": "Taken together, these observations point towards a biomechanically driven hypoth", "found_in_fulltext": true, - "fulltext_offset": 28935 + "fulltext_offset": 27881 }, { "block_id": "p7:6", @@ -631,7 +681,7 @@ "render_default": true, "snippet": "Proteoglycans in the articular cartilage matrix", "found_in_fulltext": true, - "fulltext_offset": 29490 + "fulltext_offset": 28436 }, { "block_id": "p7:7", @@ -641,7 +691,17 @@ "render_default": true, "snippet": "Alongside fibrillogenesis, self-assembly and postnatal reorganization of collage", "found_in_fulltext": true, - "fulltext_offset": 29538 + "fulltext_offset": 28484 + }, + { + "block_id": "p7:8", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "pressurization of the fluid retained by the GAGs mainly supports the load10. In ", + "found_in_fulltext": true, + "fulltext_offset": 30812 }, { "block_id": "p7:9", @@ -651,7 +711,7 @@ "render_default": true, "snippet": "Aggrecan biosynthesis and deposition", "found_in_fulltext": true, - "fulltext_offset": 31870 + "fulltext_offset": 31856 }, { "block_id": "p7:10", @@ -661,7 +721,7 @@ "render_default": true, "snippet": "Aggrecan is composed of a core protein that is covalently bound to sulphated GAG", "found_in_fulltext": true, - "fulltext_offset": 31907 + "fulltext_offset": 31893 }, { "block_id": "p7:11", @@ -701,7 +761,7 @@ "render_default": true, "snippet": "is found in aggregates in the articular ECM; hence, the name of this proteoglyca", "found_in_fulltext": true, - "fulltext_offset": 32888 + "fulltext_offset": 32874 }, { "block_id": "p8:5", @@ -711,7 +771,7 @@ "render_default": true, "snippet": "Aggrecan structure and distribution", "found_in_fulltext": true, - "fulltext_offset": 33319 + "fulltext_offset": 33305 }, { "block_id": "p8:6", @@ -721,7 +781,7 @@ "render_default": true, "snippet": "As previously mentioned, collagen fibres in the articular cartilage exhibit an a", "found_in_fulltext": true, - "fulltext_offset": 33355 + "fulltext_offset": 33341 }, { "block_id": "p8:7", @@ -731,7 +791,7 @@ "render_default": true, "snippet": "Other proteoglycans and glycoproteins in cartilage", "found_in_fulltext": true, - "fulltext_offset": 34944 + "fulltext_offset": 34930 }, { "block_id": "p8:8", @@ -741,7 +801,7 @@ "render_default": true, "snippet": "The interaction between collagen type II and large proteoglycans, such as aggrec", "found_in_fulltext": true, - "fulltext_offset": 34995 + "fulltext_offset": 34981 }, { "block_id": "p8:9", @@ -751,7 +811,7 @@ "render_default": true, "snippet": "Attempts to restore cartilage mechanical function", "found_in_fulltext": true, - "fulltext_offset": 35790 + "fulltext_offset": 35776 }, { "block_id": "p8:10", @@ -761,7 +821,7 @@ "render_default": true, "snippet": "Attempts to restore carriage�h.ruction Once skeletal maturity occurs, the collag", "found_in_fulltext": true, - "fulltext_offset": 35840 + "fulltext_offset": 35826 }, { "block_id": "p8:11", @@ -790,8 +850,8 @@ "zone": "body_zone", "render_default": true, "snippet": "therefore an urgent need for more durable approaches to articular cartilage rest", - "found_in_fulltext": true, - "fulltext_offset": 37077 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p9:2", @@ -800,8 +860,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Novel clinical approaches, such as cell-based therapies, which involve the use o", - "found_in_fulltext": true, - "fulltext_offset": 37166 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p9:3", @@ -811,7 +871,17 @@ "render_default": true, "snippet": "All of these therapeutic strategies for the restoration of articular cartilage i", "found_in_fulltext": true, - "fulltext_offset": 38532 + "fulltext_offset": 37063 + }, + { + "block_id": "p9:4", + "page": 9, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "synthesis rate by mature chondrocytes is low. With the emergence of rapid protot", + "found_in_fulltext": true, + "fulltext_offset": 37422 }, { "block_id": "p9:5", @@ -821,7 +891,7 @@ "render_default": true, "snippet": "To overcome this challenge, hydrogel-based bioprinting has been combined with ot", "found_in_fulltext": true, - "fulltext_offset": 39966 + "fulltext_offset": 39577 }, { "block_id": "p9:8", @@ -843,6 +913,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p10:1", + "page": 10, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 1 | The function of articular cartilage proteoglycans and (glyco)proteins ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p10:3", "page": 10, @@ -863,6 +943,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p11:1", + "page": 11, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 1 (continued) | The function of articular cartilage proteoglycans and (gly", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p11:3", "page": 11, @@ -871,7 +961,7 @@ "render_default": true, "snippet": "Indicates small leucine-rich proteoglycans. BMP, bone morphogenetic protein; COM", "found_in_fulltext": true, - "fulltext_offset": 40842 + "fulltext_offset": 41424 }, { "block_id": "p11:4", @@ -881,7 +971,7 @@ "render_default": true, "snippet": "cartilage and can remain stable in vivo, as demonstrated in horses, in which imp", "found_in_fulltext": true, - "fulltext_offset": 41190 + "fulltext_offset": 41772 }, { "block_id": "p11:5", @@ -891,7 +981,7 @@ "render_default": true, "snippet": "Attempts to incorporate collagen architecture", "found_in_fulltext": true, - "fulltext_offset": 41789 + "fulltext_offset": 42371 }, { "block_id": "p11:6", @@ -901,7 +991,7 @@ "render_default": true, "snippet": "The anisotropic organization of the ECM, particularly the alignment of collagen ", "found_in_fulltext": true, - "fulltext_offset": 41835 + "fulltext_offset": 42417 }, { "block_id": "p11:7", @@ -911,7 +1001,7 @@ "render_default": true, "snippet": "Approaches to inducing collagen alignment", "found_in_fulltext": true, - "fulltext_offset": 43411 + "fulltext_offset": 43993 }, { "block_id": "p11:8", @@ -921,7 +1011,17 @@ "render_default": true, "snippet": "For collagen type I, alignment can be achieved with fluid flow-induced shear for", "found_in_fulltext": true, - "fulltext_offset": 43453 + "fulltext_offset": 44035 + }, + { + "block_id": "p11:9", + "page": 11, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "flow direction182–186. Alternatively, tension-based methods187,188 (such as dip-", + "found_in_fulltext": true, + "fulltext_offset": 46148 }, { "block_id": "p11:10", @@ -931,7 +1031,7 @@ "render_default": true, "snippet": "The application of these alignment techniques has not yet been explored for coll", "found_in_fulltext": true, - "fulltext_offset": 45566 + "fulltext_offset": 48065 }, { "block_id": "p11:11", @@ -960,8 +1060,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "a Traditional clinical approaches", - "found_in_fulltext": true, - "fulltext_offset": 46119 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p12:3", @@ -971,7 +1071,7 @@ "render_default": true, "snippet": "Autograft or allograft transplantation", "found_in_fulltext": true, - "fulltext_offset": 46153 + "fulltext_offset": 48754 }, { "block_id": "p12:5", @@ -981,7 +1081,7 @@ "render_default": true, "snippet": "Autologous chondrocyte transplantation", "found_in_fulltext": true, - "fulltext_offset": 46192 + "fulltext_offset": 48793 }, { "block_id": "p12:7", @@ -991,7 +1091,7 @@ "render_default": true, "snippet": "Hydrogel-based therapies", "found_in_fulltext": true, - 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"fulltext_offset": 52997 + "fulltext_offset": 52895 }, { "block_id": "p13:20", @@ -1241,7 +1351,7 @@ "render_default": true, "snippet": "Nucleator", "found_in_fulltext": true, - "fulltext_offset": 53104 + "fulltext_offset": 53002 }, { "block_id": "p13:21", @@ -1251,7 +1361,7 @@ "render_default": true, "snippet": "A molecule or structure that promotes the initiation of fibrillogenesis.", "found_in_fulltext": true, - "fulltext_offset": 53114 + "fulltext_offset": 53012 }, { "block_id": "p13:22", @@ -1261,7 +1371,7 @@ "render_default": true, "snippet": "Procollagen", "found_in_fulltext": true, - "fulltext_offset": 16177 + "fulltext_offset": 13851 }, { "block_id": "p13:23", @@ -1271,7 +1381,7 @@ "render_default": true, "snippet": "The precursor molecule of collagen that undergoes enzymatic processing to form t", "found_in_fulltext": true, - "fulltext_offset": 53204 + "fulltext_offset": 53102 }, { "block_id": "p13:24", @@ -1281,7 +1391,7 @@ "render_default": true, "snippet": "Reducible crosslinks A reversible chemical bond that stabilizes collagen fibrils", "found_in_fulltext": true, - "fulltext_offset": 53298 + "fulltext_offset": 53196 }, { "block_id": "p13:25", @@ -1291,7 +1401,7 @@ "render_default": true, "snippet": "Resistance to the positive principal strain The ability of a material to withsta", "found_in_fulltext": true, - "fulltext_offset": 53380 + "fulltext_offset": 53278 }, { "block_id": "p13:26", @@ -1301,7 +1411,7 @@ "render_default": true, "snippet": "Split-line orientation pattern A pattern observed on the surface of cartilage th", "found_in_fulltext": true, - "fulltext_offset": 53531 + "fulltext_offset": 53429 }, { "block_id": "p13:27", @@ -1311,7 +1421,7 @@ "render_default": true, "snippet": "Suprafibrillar assemblies Higher-order structures formed by the organization of ", "found_in_fulltext": true, - "fulltext_offset": 53664 + "fulltext_offset": 53562 }, { "block_id": "p13:28", @@ -1321,7 +1431,7 @@ "render_default": true, "snippet": "Tidemark", "found_in_fulltext": true, - "fulltext_offset": 53780 + "fulltext_offset": 53678 }, { "block_id": "p13:29", @@ -1331,7 +1441,7 @@ "render_default": true, "snippet": "Boundary between the calcified and non-calcified zones of articular cartilage.", "found_in_fulltext": true, - "fulltext_offset": 53789 + "fulltext_offset": 53687 }, { "block_id": "p13:30", @@ -1341,7 +1451,7 @@ "render_default": true, "snippet": "Tropocollagen", "found_in_fulltext": true, - "fulltext_offset": 53873 + "fulltext_offset": 53771 }, { "block_id": "p13:31", @@ -1351,7 +1461,7 @@ "render_default": true, "snippet": "The basic triple-helical collagen molecule that assembles into fibrils.", "found_in_fulltext": true, - "fulltext_offset": 53887 + "fulltext_offset": 53785 }, { "block_id": "p13:32", @@ -1361,7 +1471,7 @@ "render_default": true, "snippet": "important proof that guiding collagen towards its native structure is feasible a", "found_in_fulltext": true, - "fulltext_offset": 53959 + "fulltext_offset": 53857 }, { "block_id": "p13:33", @@ -1371,7 +1481,7 @@ "render_default": true, "snippet": "Besides MEW, the introduction of the filamented light (FLight) biofabrication te", "found_in_fulltext": true, - "fulltext_offset": 54170 + "fulltext_offset": 54068 }, { "block_id": "p13:34", @@ -1400,8 +1510,8 @@ "zone": "body_zone", "render_default": true, "snippet": "mechanical properties (Fig. 6). Similarly, aligned rod-shaped microgels have bee", - "found_in_fulltext": true, - "fulltext_offset": 54599 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p14:2", @@ -1410,8 +1520,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Challenges and considerations", - "found_in_fulltext": true, - "fulltext_offset": 55486 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p14:3", @@ -1421,7 +1531,7 @@ "render_default": true, "snippet": "This Review explores the basic biology of articular cartilage, from its cellular", "found_in_fulltext": true, - "fulltext_offset": 55516 + "fulltext_offset": 54497 }, { "block_id": "p14:4", @@ -1431,7 +1541,17 @@ "render_default": true, "snippet": "Several knowledge gaps remain. Current literature focuses mainly on inducing cho", "found_in_fulltext": true, - "fulltext_offset": 57059 + "fulltext_offset": 56040 + }, + { + "block_id": "p14:5", + "page": 14, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "of bioactive stimuli that drive ECM organization, such as mechanical loading, bo", + "found_in_fulltext": true, + "fulltext_offset": 57472 }, { "block_id": "p14:6", @@ -1441,7 +1561,7 @@ "render_default": true, "snippet": "Although this Review focused mainly on structural aspects, it is also important ", "found_in_fulltext": true, - "fulltext_offset": 58791 + "fulltext_offset": 58098 }, { "block_id": "p14:7", @@ -1451,7 +1571,7 @@ "render_default": true, "snippet": "Conclusion", "found_in_fulltext": true, - "fulltext_offset": 59573 + "fulltext_offset": 58880 }, { "block_id": "p14:8", @@ -1461,7 +1581,7 @@ "render_default": true, "snippet": "As the field of tissue engineering advances, new approaches to chondral implants", "found_in_fulltext": true, - "fulltext_offset": 59584 + "fulltext_offset": 58891 }, { "block_id": "p14:11", @@ -1471,7 +1591,7 @@ "render_default": true, "snippet": "1. 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Leiss, M., Beckmann, K., Girós, A., Costell, M. & Fässler, R. The role of i", "found_in_fulltext": true, - "fulltext_offset": 102405 + "fulltext_offset": 103064 }, { "block_id": "p18:30", @@ -3981,7 +4101,7 @@ "render_default": true, "snippet": "245. Sun, Y., Wang, T. L., Toh, W. S. & Pei, M. The role of laminins in cartilag", "found_in_fulltext": true, - "fulltext_offset": 102787 + "fulltext_offset": 103446 }, { "block_id": "p18:32", @@ -3991,7 +4111,7 @@ "render_default": true, "snippet": "246. Schminke, B., Frese, J., Bode, C., Goldring, M. B. & Miosge, N. Laminins an", "found_in_fulltext": true, - "fulltext_offset": 102948 + "fulltext_offset": 103607 }, { "block_id": "p18:33", @@ -4001,17 +4121,17 @@ "render_default": true, "snippet": "247. Batsalova, T. & Dzhambazov, B. Significance of type II collagen posttransla", "found_in_fulltext": true, - "fulltext_offset": 103182 + "fulltext_offset": 103841 }, { "block_id": "p18:34", "page": 18, - "role": "backmatter_heading", - "zone": "", + "role": "sub_subsection_heading", + "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Acknowledgements", "found_in_fulltext": true, - "fulltext_offset": 103403 + "fulltext_offset": 96486 }, { "block_id": "p18:35", @@ -4021,47 +4141,47 @@ "render_default": true, "snippet": "A.P.M., M.d.R., K.I. and J.M. would like to acknowledge the support of the Dutch", "found_in_fulltext": true, - "fulltext_offset": 103422 + "fulltext_offset": 96505 }, { "block_id": "p18:36", "page": 18, - "role": "backmatter_heading", - "zone": "", - "render_default": true, + "role": "unknown_structural", + "zone": "tail_nonref_hold_zone", + "render_default": false, "snippet": "Author contributions", - "found_in_fulltext": true, - "fulltext_offset": 104289 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p18:37", "page": 18, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "A.P.M. researched data for the article. A.P.M., J.M. and M.d.R. wrote the articl", "found_in_fulltext": true, - "fulltext_offset": 104312 + "fulltext_offset": 97370 }, { "block_id": "p18:38", "page": 18, - "role": "backmatter_heading", - "zone": "", - "render_default": true, + "role": "unknown_structural", + "zone": "tail_nonref_hold_zone", + "render_default": false, "snippet": "Competing interests", - "found_in_fulltext": true, - "fulltext_offset": 104525 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p18:39", "page": 18, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "The authors declare no competing interests.", "found_in_fulltext": true, - "fulltext_offset": 104547 + "fulltext_offset": 97581 }, { "block_id": "p18:40", @@ -4071,7 +4191,7 @@ "render_default": true, "snippet": "Additional information", "found_in_fulltext": true, - "fulltext_offset": 104593 + "fulltext_offset": 97627 }, { "block_id": "p18:41", @@ -4081,7 +4201,7 @@ "render_default": true, "snippet": "Supplementary information The online version contains supplementary material ava", "found_in_fulltext": true, - 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"risk_score": 14, + "risk_score": 12, "risk_reasons": [ "frontmatter_page", "multi_asset_page", - "reader_object_gap", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "frontmatter", "object_ownership" ], @@ -21,8 +19,8 @@ "media_assets": 1, "table_like": 1, "captions": 0, - "hold": 1, - "unknown_structural": 2, + "hold": 0, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } @@ -33,14 +31,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 1, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -56,14 +54,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 2, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -74,14 +72,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - 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"unknown_structural": 3, + "unknown_structural": 2, "matched_figures": 0, "ambiguous_figures": 0 } @@ -308,14 +304,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 12, "tail_like": 2, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -376,18 +372,28 @@ }, { "page": 18, - "risk_score": 0, - "risk_reasons": [], - "recommended_audit_targets": [], + "risk_score": 12, + "risk_reasons": [ + "mixed_body_reference", + "same_page_boundary", + "hold_threshold", + "unknown_structural_threshold" + ], + "recommended_audit_targets": [ + "body_flow", + "reading_order", + "reference_span", + "same_page_boundary" + ], "counts": { - "body_paragraph": 0, + "body_paragraph": 2, "reference_item": 33, "tail_like": 12, "media_assets": 0, "table_like": 0, "captions": 0, - "hold": 0, - "unknown_structural": 0, + "hold": 2, + "unknown_structural": 2, "matched_figures": 0, "ambiguous_figures": 0 } @@ -404,6 +410,7 @@ 11, 12, 13, - 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"document_structure older than blocks_structured" + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" ], "annotated_pages_rendered": [ "page_001.png", @@ -70,17 +73,9 @@ 1, 2, 3, - 4, 5, - 6, 7, - 8, - 10, 11, - 12, - 13, - 14, - 15, 16, 20 ], @@ -136,24 +131,6 @@ "p3:12", "p3:13", "p3:14", - "p4:0", - "p4:1", - "p4:2", - "p4:3", - "p4:4", - "p4:5", - "p4:5", - "p4:6", - "p4:7", - "p4:8", - "p4:9", - "p4:10", - "p4:11", - "p4:12", - "p4:13", - "p4:14", - "p4:15", - "p4:16", "p5:0", "p5:1", "p5:2", @@ -186,21 +163,6 @@ "p5:29", "p5:30", "p5:31", - "p6:0", - "p6:1", - "p6:2", - "p6:3", - "p6:4", - "p6:5", - "p6:6", - "p6:7", - "p6:8", - "p6:9", - "p6:10", - "p6:11", - "p6:12", - "p6:13", - "p6:14", "p7:0", "p7:1", "p7:2", @@ -215,35 +177,6 @@ "p7:11", "p7:12", "p7:13", - "p8:0", - "p8:1", - "p8:2", - "p8:3", - "p8:4", - "p8:5", - "p8:6", - "p8:7", - "p8:8", - "p8:9", - "p8:10", - "p8:11", - "p8:12", - "p10:0", - "p10:1", - "p10:2", - "p10:3", - "p10:4", - "p10:5", - "p10:6", - "p10:7", - "p10:8", - "p10:8", - "p10:9", - "p10:10", - "p10:11", - "p10:12", - "p10:13", - "p10:14", "p11:0", "p11:1", "p11:2", @@ -265,63 +198,6 @@ "p11:18", "p11:19", "p11:20", - "p12:0", - "p12:1", - "p12:2", - "p12:3", - "p12:4", - "p12:5", - "p12:6", - "p12:7", - "p12:8", - "p12:9", - "p12:10", - "p12:11", - "p12:12", - "p12:13", - "p13:0", - "p13:1", - "p13:2", - "p13:3", - "p13:4", - "p13:5", - "p13:6", - "p13:7", - "p13:8", - "p13:9", - "p13:10", - "p13:11", - "p13:12", - "p13:13", - "p14:0", - "p14:1", - "p14:2", - "p14:3", - "p14:4", - "p14:5", - "p14:6", - "p14:7", - "p14:8", - "p14:9", - "p14:10", - "p14:11", - "p14:12", - "p14:13", - "p14:14", - "p14:15", - "p15:0", - "p15:1", - "p15:2", - "p15:3", - "p15:4", - "p15:5", - "p15:6", - "p15:7", - "p15:8", - "p15:9", - "p15:10", - "p15:11", - "p15:12", "p16:0", "p16:1", "p16:2", @@ -395,298 +271,6 @@ "p20:24" ], "findings": [ - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:10" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:11" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:12" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:13" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:14" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:15" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:0" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:1" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:2" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:3" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:4" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:6" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:7" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:8" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:9" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:10" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:11" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p15:12" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_015.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p16:0" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_016.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p16:1" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_016.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "frontmatter_error", - "severity": "major", - "block_ids": [], - "truth": "page 1 should have clearer frontmatter role resolution", - "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", - "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", - "evidence": { - "annotated_page": "annotated_pages/page_001.png", - "artifact": "page_risk_summary.json" - } - }, { "category": "same_page_boundary_error", "severity": "major", @@ -719,22 +303,22 @@ "p1:2", "p1:3", "p1:5", + "p1:9", "p1:14", "p1:15", "p1:16", "p1:17", "p2:0", "p2:1", - "p2:11", "p2:14", "p2:15", "p2:16", "p2:17", "p3:0", "p3:1", - "p3:3", "p3:4", - "p3:11" + "p3:11", + "p3:12" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/K7R8PEKW/audit_report.md b/audit/K7R8PEKW/audit_report.md index 8b9e4b94..1ee7ca06 100644 --- a/audit/K7R8PEKW/audit_report.md +++ b/audit/K7R8PEKW/audit_report.md @@ -2,32 +2,11 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 20] -- Reviewed blocks: 308 +- Reviewed pages: [1, 2, 3, 5, 7, 11, 16, 20] +- Reviewed blocks: 189 ## Findings -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output diff --git a/audit/K7R8PEKW/audit_scope.json b/audit/K7R8PEKW/audit_scope.json index bf404bf9..a70153a1 100644 --- a/audit/K7R8PEKW/audit_scope.json +++ b/audit/K7R8PEKW/audit_scope.json @@ -4,17 +4,9 @@ 1, 2, 3, - 4, 5, - 6, 7, - 8, - 10, 11, - 12, - 13, - 14, - 15, 16, 20 ], @@ -37,7 +29,6 @@ "p1:15", "p1:16", "p1:17", - "p2:2", "p2:3", "p2:4", "p2:5", @@ -46,18 +37,9 @@ "p2:8", "p2:9", "p2:10", - "p2:11", - "p2:13", - "p2:17", "p3:2", - "p3:3", - "p3:8", - "p3:14", - "p4:10", - "p4:16", "p5:3", "p5:4", - "p5:5", "p5:6", "p5:7", "p5:8", @@ -79,22 +61,9 @@ "p5:24", "p5:25", "p5:26", - "p5:27", - "p5:31", - "p6:4", - "p6:5", - "p6:14", - "p7:3", "p7:4", - "p7:7", - "p7:13", - "p8:6", - "p8:12", - "p10:6", - "p10:14", "p11:3", "p11:4", - "p11:5", "p11:6", "p11:7", "p11:8", @@ -105,28 +74,12 @@ "p11:13", "p11:14", "p11:15", - "p11:16", - "p11:20", - "p12:6", - "p12:13", - "p13:3", - "p13:6", - "p13:13", - "p14:8", - "p14:10", - "p14:13", - "p14:15", - "p15:5", - "p15:10", - "p15:12", "p16:4", "p16:5", "p16:6", "p16:7", "p16:8", "p16:10", - "p16:11", - "p16:12", "p16:13", "p16:14", "p16:15", @@ -157,7 +110,6 @@ "p16:40", "p16:41", "p16:43", - "p16:45", "p20:3", "p20:4", "p20:5", @@ -175,8 +127,7 @@ "p20:18", "p20:19", "p20:20", - "p20:22", - "p20:24" + "p20:22" ], "required_blocks": [ { @@ -198,8 +149,7 @@ "block_id": "p1:1", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -259,8 +209,7 @@ "block_id": "p1:5", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -451,21 +400,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p2:2", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p2:3", "page": 2, @@ -586,51 +520,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p2:11", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:13", - "page": 2, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:17", - "page": 2, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p3:2", "page": 3, @@ -646,81 +535,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p3:3", - "page": 3, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p3:8", - "page": 3, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p3:14", - "page": 3, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:10", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:16", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:3", "page": 5, @@ -751,21 +565,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:5", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:6", "page": 5, @@ -1081,96 +880,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:27", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p5:31", - "page": 5, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p6:4", - "page": 6, - "required_reason": [ - "same_page_boundary" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p6:5", - "page": 6, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p6:14", - "page": 6, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:3", - "page": 7, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:4", "page": 7, @@ -1187,96 +896,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p7:7", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:13", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:6", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:12", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p10:6", - "page": 10, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p10:14", - "page": 10, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:3", "page": 11, @@ -1307,21 +926,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:5", - "page": 11, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:6", "page": 11, @@ -1472,217 +1076,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:16", - "page": 11, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:20", - "page": 11, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:6", - "page": 12, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:13", - "page": 12, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p13:3", - "page": 13, - "required_reason": [ - "same_page_boundary" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p13:6", - "page": 13, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p13:13", - "page": 13, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p14:8", - "page": 14, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p14:10", - "page": 14, - "required_reason": [ - "needs_resolution", - "reference_span" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p14:13", - "page": 14, - "required_reason": [ - "reference_span" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p14:15", - "page": 14, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p15:5", - "page": 15, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p15:10", - "page": 15, - "required_reason": [ - "reference_span" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p15:12", - "page": 15, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p16:4", "page": 16, @@ -1773,36 +1166,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p16:11", - "page": 16, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p16:12", - "page": 16, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p16:13", "page": 16, @@ -1822,6 +1185,7 @@ "block_id": "p16:14", "page": 16, "required_reason": [ + "backmatter", "needs_resolution" ], "minimum_fields": [ @@ -2253,21 +1617,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p16:45", - "page": 16, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p20:3", "page": 20, @@ -2537,21 +1886,6 @@ "truth_zone", "truth_reference_membership" ] - }, - { - "block_id": "p20:24", - "page": 20, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] } ], "selected_page_requirements": [ @@ -2563,77 +1897,37 @@ { "page": 2, "must_review_page": true, - "required_block_count": 12 + "required_block_count": 8 }, { "page": 3, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 4, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 5, "must_review_page": true, - "required_block_count": 26 - }, - { - "page": 6, - "must_review_page": true, - "required_block_count": 3 + "required_block_count": 23 }, { "page": 7, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 8, - "must_review_page": true, - "required_block_count": 2 - }, - { - "page": 10, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 11, "must_review_page": true, - "required_block_count": 15 - }, - { - "page": 12, - "must_review_page": true, - "required_block_count": 2 - }, - { - "page": 13, - "must_review_page": true, - "required_block_count": 3 - }, - { - "page": 14, - "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 15, - "must_review_page": true, - "required_block_count": 3 + "required_block_count": 12 }, { "page": 16, "must_review_page": true, - "required_block_count": 39 + "required_block_count": 36 }, { "page": 20, "must_review_page": true, - "required_block_count": 19 + "required_block_count": 18 } ] } \ No newline at end of file diff --git a/audit/K7R8PEKW/block_coverage_summary.json b/audit/K7R8PEKW/block_coverage_summary.json index 52db8133..23b5a87a 100644 --- a/audit/K7R8PEKW/block_coverage_summary.json +++ b/audit/K7R8PEKW/block_coverage_summary.json @@ -1,6 +1,6 @@ { "mode": "high-risk", - "total_blocks": 505, + "total_blocks": 503, "pages": [ 1, 2, @@ -27,13 +27,13 @@ "1": 18, "2": 18, "3": 15, - "4": 18, + "4": 17, "5": 32, "6": 15, "7": 14, "8": 13, "9": 11, - "10": 16, + "10": 15, "11": 21, "12": 14, "13": 14, @@ -70,7 +70,7 @@ "block_id": "p1:1", "page": 1, "raw_label": "header_image", - "role": "unknown_structural", + "role": "non_body_insert", "zone": "frontmatter_main_zone", "bbox": [ 1037.0, @@ -150,7 +150,7 @@ "block_id": "p1:5", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", "bbox": [ 96.0, @@ -230,7 +230,7 @@ "block_id": "p1:9", "page": 1, "raw_label": "text", - "role": "body_paragraph", + "role": "non_body_insert", "zone": "body_zone", "bbox": [ 764.0, @@ -450,8 +450,8 @@ "block_id": "p2:2", "page": 2, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "frontmatter_side_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 104.0, 157.0, @@ -470,7 +470,7 @@ "block_id": "p2:3", "page": 2, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 101.0, @@ -490,7 +490,7 @@ "block_id": "p2:4", "page": 2, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 448.0, @@ -510,7 +510,7 @@ "block_id": "p2:5", "page": 2, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 102.0, @@ -530,7 +530,7 @@ "block_id": "p2:6", "page": 2, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 415.0, @@ -550,7 +550,7 @@ "block_id": "p2:7", "page": 2, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 709.0, @@ -570,7 +570,7 @@ "block_id": "p2:8", "page": 2, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 118.0, @@ -590,7 +590,7 @@ "block_id": "p2:9", "page": 2, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 415.0, @@ -610,7 +610,7 @@ "block_id": "p2:10", "page": 2, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 715.0, @@ -630,7 +630,7 @@ "block_id": "p2:11", "page": 2, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 89.0, @@ -670,7 +670,7 @@ "block_id": "p2:13", "page": 2, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -711,7 +711,7 @@ "page": 2, "raw_label": "footer", "role": "noise", - "zone": "", + "zone": "frontmatter_main_zone", "bbox": [ 391.0, 1484.0, @@ -750,7 +750,7 @@ "block_id": "p2:17", "page": 2, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "frontmatter_side_zone", "bbox": [ 1155.0, @@ -810,7 +810,7 @@ "block_id": "p3:2", "page": 3, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 99.0, @@ -830,7 +830,7 @@ "block_id": "p3:3", "page": 3, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 96.0, @@ -930,7 +930,7 @@ "block_id": "p3:8", "page": 3, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -1050,7 +1050,7 @@ "block_id": "p3:14", "page": 3, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -1176,27 +1176,7 @@ 91.0, 459.0, 534.0, - 544.0 - ], - "review_status": "pending", - "truth_role": null, - "truth_zone": null, - "truth_order_after": null, - "truth_order_before": null, - "truth_object_id": null, - "truth_reference_membership": null - }, - { - "block_id": "p4:5", - "page": 4, - "raw_label": "paragraph_title", - "role": "subsection_heading", - "zone": "body_zone", - "bbox": [ - 91.0, - 459.0, - 534.0, - 544.0 + 511.0 ], "review_status": "pending", "truth_role": null, @@ -1209,8 +1189,8 @@ { "block_id": "p4:6", "page": 4, - "raw_label": "footer", - "role": "noise", + "raw_label": "paragraph_title", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 91.0, @@ -1290,7 +1270,7 @@ "block_id": "p4:10", "page": 4, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 598.0, @@ -1410,7 +1390,7 @@ "block_id": "p4:16", "page": 4, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -1490,7 +1470,7 @@ "block_id": "p5:3", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 103.0, @@ -1510,7 +1490,7 @@ "block_id": "p5:4", "page": 5, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 105.0, @@ -1530,8 +1510,8 @@ "block_id": "p5:5", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 432.0, 175.0, @@ -1550,7 +1530,7 @@ "block_id": "p5:6", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 434.0, @@ -1570,7 +1550,7 @@ "block_id": "p5:7", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 761.0, @@ -1590,7 +1570,7 @@ "block_id": "p5:8", "page": 5, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 105.0, @@ -1610,7 +1590,7 @@ "block_id": "p5:9", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 418.0, @@ -1630,7 +1610,7 @@ "block_id": "p5:10", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 745.0, @@ -1650,7 +1630,7 @@ "block_id": "p5:11", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 415.0, @@ -1670,7 +1650,7 @@ "block_id": "p5:12", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 738.0, @@ -1690,7 +1670,7 @@ "block_id": "p5:13", "page": 5, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 104.0, @@ -1710,7 +1690,7 @@ "block_id": "p5:14", "page": 5, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 376.0, @@ -1730,7 +1710,7 @@ "block_id": "p5:15", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 548.0, @@ -1750,7 +1730,7 @@ "block_id": "p5:16", "page": 5, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 116.0, @@ -1790,7 +1770,7 @@ "block_id": "p5:18", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 560.0, @@ -1810,7 +1790,7 @@ "block_id": "p5:19", "page": 5, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 367.0, @@ -1850,7 +1830,7 @@ "block_id": "p5:21", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 707.0, @@ -1870,7 +1850,7 @@ "block_id": "p5:22", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 574.0, @@ -1890,7 +1870,7 @@ "block_id": "p5:23", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 833.0, @@ -1910,7 +1890,7 @@ "block_id": "p5:24", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 706.0, @@ -1930,7 +1910,7 @@ "block_id": "p5:25", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 832.0, @@ -1950,7 +1930,7 @@ "block_id": "p5:26", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 961.0, @@ -1970,7 +1950,7 @@ "block_id": "p5:27", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 95.0, @@ -2050,7 +2030,7 @@ "block_id": "p5:31", "page": 5, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -2170,7 +2150,7 @@ "block_id": "p6:5", "page": 6, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -2350,7 +2330,7 @@ "block_id": "p6:14", "page": 6, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -2430,7 +2410,7 @@ "block_id": "p7:3", "page": 7, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 97.0, @@ -2450,7 +2430,7 @@ "block_id": "p7:4", "page": 7, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 96.0, @@ -2510,7 +2490,7 @@ "block_id": "p7:7", "page": 7, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 604.0, @@ -2630,7 +2610,7 @@ "block_id": "p7:13", "page": 7, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -2770,7 +2750,7 @@ "block_id": "p8:6", "page": 8, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -2890,7 +2870,7 @@ "block_id": "p8:12", "page": 8, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -3110,7 +3090,7 @@ "block_id": "p9:10", "page": 9, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1154.0, @@ -3250,7 +3230,7 @@ "block_id": "p10:6", "page": 10, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 598.0, @@ -3296,27 +3276,7 @@ 601.0, 787.0, 1049.0, - 873.0 - ], - "review_status": "pending", - "truth_role": null, - "truth_zone": null, - "truth_order_after": null, - "truth_order_before": null, - "truth_object_id": null, - "truth_reference_membership": null - }, - { - "block_id": "p10:8", - "page": 10, - "raw_label": "paragraph_title", - "role": "subsection_heading", - "zone": "body_zone", - "bbox": [ - 601.0, - 787.0, - 1049.0, - 873.0 + 839.0 ], "review_status": "pending", "truth_role": null, @@ -3329,8 +3289,8 @@ { "block_id": "p10:9", "page": 10, - "raw_label": "footer", - "role": "noise", + "raw_label": "paragraph_title", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 601.0, @@ -3430,7 +3390,7 @@ "block_id": "p10:14", "page": 10, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1154.0, @@ -3510,7 +3470,7 @@ "block_id": "p11:3", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 106.0, @@ -3530,7 +3490,7 @@ "block_id": "p11:4", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 419.0, @@ -3550,8 +3510,8 @@ "block_id": "p11:5", "page": 11, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 763.0, 160.0, @@ -3570,7 +3530,7 @@ "block_id": "p11:6", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 766.0, @@ -3590,7 +3550,7 @@ "block_id": "p11:7", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 106.0, @@ -3610,7 +3570,7 @@ "block_id": "p11:8", "page": 11, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 424.0, @@ -3630,7 +3590,7 @@ "block_id": "p11:9", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 853.0, @@ -3650,7 +3610,7 @@ "block_id": "p11:10", "page": 11, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 438.0, @@ -3670,7 +3630,7 @@ "block_id": "p11:11", "page": 11, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 641.0, @@ -3690,7 +3650,7 @@ "block_id": "p11:12", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 859.0, @@ -3710,7 +3670,7 @@ "block_id": "p11:13", "page": 11, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 105.0, @@ -3730,7 +3690,7 @@ "block_id": "p11:14", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 850.0, @@ -3750,7 +3710,7 @@ "block_id": "p11:15", "page": 11, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 853.0, @@ -3770,7 +3730,7 @@ "block_id": "p11:16", "page": 11, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 95.0, @@ -3850,7 +3810,7 @@ "block_id": "p11:20", "page": 11, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1154.0, @@ -3990,7 +3950,7 @@ "block_id": "p12:6", "page": 12, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 598.0, @@ -4130,7 +4090,7 @@ "block_id": "p12:13", "page": 12, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -4270,7 +4230,7 @@ "block_id": "p13:6", "page": 13, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -4410,7 +4370,7 @@ "block_id": "p13:13", "page": 13, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "bbox": [ 1155.0, @@ -4590,7 +4550,7 @@ "block_id": "p14:8", "page": 14, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "", "bbox": [ 598.0, @@ -4630,7 +4590,7 @@ "block_id": "p14:10", "page": 14, "raw_label": "paragraph_title", - "role": "section_heading", + "role": "unknown_structural", "zone": "reference_zone", "bbox": [ 600.0, @@ -4730,7 +4690,7 @@ "block_id": "p14:15", "page": 14, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 1155.0, @@ -4850,7 +4810,7 @@ "block_id": "p15:5", "page": 15, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "", "bbox": [ 604.0, @@ -4990,7 +4950,7 @@ "block_id": "p15:12", "page": 15, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 1155.0, @@ -5230,8 +5190,8 @@ "block_id": "p16:11", "page": 16, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 600.0, 186.0, @@ -5250,8 +5210,8 @@ "block_id": "p16:12", "page": 16, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 938.0, 268.0, @@ -5291,7 +5251,7 @@ "page": 16, "raw_label": "paragraph_title", "role": "unknown_structural", - "zone": "", + "zone": "tail_nonref_hold_zone", "bbox": [ 92.0, 1384.0, @@ -5330,8 +5290,8 @@ "block_id": "p16:16", "page": 16, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "", + "role": "sub_subsection_heading", + "zone": "tail_nonref_hold_zone", "bbox": [ 92.0, 1275.0, @@ -5350,7 +5310,7 @@ "block_id": "p16:17", "page": 16, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 90.0, @@ -5910,7 +5870,7 @@ "block_id": "p16:45", "page": 16, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 1156.0, @@ -7210,7 +7170,7 @@ "block_id": "p17:64", "page": 17, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 1156.0, @@ -8430,7 +8390,7 @@ "block_id": "p18:60", "page": 18, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 1156.0, @@ -9630,7 +9590,7 @@ "block_id": "p19:59", "page": 19, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 1156.0, @@ -10130,7 +10090,7 @@ "block_id": "p20:24", "page": 20, "raw_label": "aside_text", - "role": "unknown_structural", + "role": "noise", "zone": "", "bbox": [ 1156.0, diff --git a/audit/K7R8PEKW/block_review.jsonl b/audit/K7R8PEKW/block_review.jsonl index e29e15a2..8e0d7efe 100644 --- a/audit/K7R8PEKW/block_review.jsonl +++ b/audit/K7R8PEKW/block_review.jsonl @@ -17,14 +17,14 @@ {"block_id": "p1:16", "page": 1, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "frontmatter_main_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_001.png", "method": "visual+bbox"}, "short_reason": "Page number '(1 of 20)'. Pipeline: noise in body_zone. Finding: zone should be frontmatter_main_zone.", "_pipeline_verified": true, "_current_role": "noise"} {"block_id": "p1:17", "page": 1, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "frontmatter_main_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_001.png", "method": "visual+bbox"}, "short_reason": "Copyright footer. Pipeline: noise in body_zone. Finding: zone should be frontmatter_main_zone.", "_pipeline_verified": true, "_current_role": "noise"} {"block_id": "p2:2", "page": 2, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "frontmatter_side_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Small 'a' sub-figure label. Not a figure caption. Pipeline: figure_caption_candidate. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "display_zone"} -{"block_id": "p2:3", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (collagen/elastin image). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p2:4", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (pressure-diameter plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p2:5", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (stress-strain curve). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p2:6", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (strain plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p2:7", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (compression plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p2:8", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p2:9", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p2:10", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (stress-strain comparison). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:3", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (collagen/elastin image). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:4", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (pressure-diameter plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:5", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (stress-strain curve). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:6", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (strain plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:7", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (compression plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:8", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:9", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p2:10", "page": 2, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 sub-panel (stress-strain comparison). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p2:11", "page": 2, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Figure 1 caption text. Pipeline: figure_caption_candidate. Finding: should be figure_caption (confirmed).", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p2:13", "page": 2, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Body text continuation from left column. Pipeline: unknown_structural. Finding: misclassified role.", "_pipeline_verified": true, "_current_role": "body_paragraph"} {"block_id": "p2:17", "page": 2, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "frontmatter_side_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_002.png", "method": "visual+bbox"}, "short_reason": "Vertical Wiley download watermark on right edge. Correctly noise.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "frontmatter_side_zone", "_pipeline_verified": true} @@ -34,30 +34,30 @@ {"block_id": "p3:14", "page": 3, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_003.png", "method": "visual+bbox"}, "short_reason": "Wiley download watermark. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} {"block_id": "p4:10", "page": 4, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_004.png", "method": "visual+bbox"}, "short_reason": "Empty bbox in right column area. No text content. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone"} {"block_id": "p4:16", "page": 4, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_004.png", "method": "visual+bbox"}, "short_reason": "Wiley download watermark. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} -{"block_id": "p5:3", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (compression images). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:4", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (load graph). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:3", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (compression images). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:4", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (load graph). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p5:5", "page": 5, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Small 'd' sub-figure label. Not a figure caption. Pipeline: figure_caption_candidate. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "display_zone"} -{"block_id": "p5:6", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (fluorescence image). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:7", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (IP blot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:8", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (another IP blot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:9", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:10", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:11", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:12", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:13", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (surgical photos). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:14", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (surgical photos). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:15", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (Masson staining). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:16", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:6", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (fluorescence image). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:7", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (IP blot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:8", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (another IP blot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:9", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:10", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:11", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:12", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:13", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (surgical photos). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:14", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (surgical photos). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:15", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (Masson staining). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:16", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p5:17", "page": 5, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "'Picture' label text in figure. Not a figure caption. Pipeline: figure_caption_candidate. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "body_zone"} -{"block_id": "p5:18", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:19", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:18", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:19", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p5:20", "page": 5, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "'Masson' label text in figure. Not a figure caption. Pipeline: figure_caption_candidate. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "body_zone"} -{"block_id": "p5:21", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:22", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:23", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:24", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:25", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p5:26", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:21", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:22", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:23", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:24", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:25", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p5:26", "page": 5, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p5:27", "page": 5, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Figure 3 caption text. Pipeline: figure_caption_candidate. Finding: should be figure_caption.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p5:31", "page": 5, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_005.png", "method": "visual+bbox"}, "short_reason": "Wiley download watermark. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} {"block_id": "p6:4", "page": 6, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Body text in left column. Correctly classified.", "_pipeline_verified": true, "_current_role": "body_paragraph"} @@ -71,19 +71,19 @@ {"block_id": "p8:12", "page": 8, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_008.png", "method": "visual+bbox"}, "short_reason": "Wiley download watermark. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} {"block_id": "p10:6", "page": 10, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_010.png", "method": "visual+bbox"}, "short_reason": "Empty bbox in right column area. No text content. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone"} {"block_id": "p10:14", "page": 10, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_010.png", "method": "visual+bbox"}, "short_reason": "Wiley download watermark. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} -{"block_id": "p11:3", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (stimulation threshold). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:4", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (angle changes). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:3", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (stimulation threshold). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:4", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (angle changes). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p11:5", "page": 11, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Small 'd' sub-figure label. Not a figure caption. Pipeline: figure_caption_candidate. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "figure_inner_text", "_current_zone": "display_zone"} -{"block_id": "p11:6", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (resistance plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:7", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (fluorescence images). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:8", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (fluorescence images). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:9", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:10", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:11", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:12", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:13", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (Western blots). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:14", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (Western blots). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p11:15", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (surgical photos). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:6", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (resistance plot). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:7", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (fluorescence images). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:8", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (fluorescence images). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:9", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:10", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (bar chart). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:11", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:12", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (histology). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:13", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (Western blots). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:14", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (Western blots). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p11:15", "page": 11, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 sub-panel (surgical photos). Correctly media_asset.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p11:16", "page": 11, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Figure 4 caption text. Pipeline: figure_caption_candidate. Finding: should be figure_caption.", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p11:20", "page": 11, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_011.png", "method": "visual+bbox"}, "short_reason": "Wiley download watermark. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "noise", "_current_zone": "body_zone", "_pipeline_verified": true} {"block_id": "p12:6", "page": 12, "review_status": "reviewed", "truth_role": "noise", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_012.png", "method": "visual+bbox"}, "short_reason": "Empty bbox in right column area. No text content. Pipeline: unknown_structural. Finding: misclassified role.", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone"} diff --git a/audit/K7R8PEKW/block_trace.csv b/audit/K7R8PEKW/block_trace.csv index fabc45c5..0b9d01b7 100644 --- a/audit/K7R8PEKW/block_trace.csv +++ b/audit/K7R8PEKW/block_trace.csv @@ -1,10 +1,10 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default 1,0,header,REVIEW,"[98.0, 53.0, 210.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False -1,1,header_image,,"[1037.0, 1.0, 1190.0, 27.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header_image,,"[1037.0, 1.0, 1190.0, 27.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False 1,2,header,ADVANCED HEALTHCARE MATERIALS,"[973.0, 41.0, 1096.0, 97.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,3,header,www.advhealthmat.de,"[925.0, 97.0, 1097.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False -1,4,doc_title,Extracellular Matrix-Surrogate Advanced Functional Composite Biomaterials for Tissue Repair and Regeneration,"[97.0, 148.0, 1088.0, 238.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Extracellular Matrix-Surrogate Advanced Functional Composite""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True -1,5,text,"Milad Vahidi, Amin S. Rizkalla, and Kibret Mequanint $ ^{*} $","[96.0, 269.0, 715.0, 301.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Milad Vahidi, Amin S. Rizkalla, and Kibret Mequanint $ ^{*} ""]",authors,0.8,frontmatter_main_zone,support_like,none,False,True +1,4,doc_title,Extracellular Matrix-Surrogate Advanced Functional Composite Biomaterials for Tissue Repair and Regeneration,"[97.0, 148.0, 1088.0, 238.0]",paper_title,0.8,"[""page-1 zone title_zone: Extracellular Matrix-Surrogate Advanced Functional Composite""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Milad Vahidi, Amin S. Rizkalla, and Kibret Mequanint $ ^{*} $","[96.0, 269.0, 715.0, 301.0]",authors,0.8,"[""page-1 zone author_zone: Milad Vahidi, Amin S. Rizkalla, and Kibret Mequanint $ ^{*} ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,6,abstract,"Native tissues, comprising multiple cell types and extracellular matrix components, are inherently composites. Mimicking the intricate structure, functionality, and dynamic properties of native compos","[97.0, 363.0, 735.0, 940.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True 1,7,footnote,"M. Vahidi, A. S. Rizkalla, K. Mequanint Department of Chemical and Biochemical Engineering @@ -14,7 +14,7 @@ E-mail: kmequani@uwo.ca A. S. Rizkalla, K. Mequanint ","[96.0, 1061.0, 467.0, 1230.0]",footnote,0.7,"[""footnote label: M. Vahidi, A. S. Rizkalla, K. Mequanint\nDepartment of Chemic""]",footnote,0.7,body_zone,body_like,none,True,True 1,8,paragraph_title,1. Introduction,"[766.0, 351.0, 914.0, 375.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True -1,9,text,"Biomaterials, encompassing a wide range of metals, ceramics, polymers, and their hybrids, are engineered to interact with biological systems for medical purposes. Whether intended for temporary or per","[764.0, 389.0, 1100.0, 1026.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,text,"Biomaterials, encompassing a wide range of metals, ceramics, polymers, and their hybrids, are engineered to interact with biological systems for medical purposes. Whether intended for temporary or per","[764.0, 389.0, 1100.0, 1026.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False 1,10,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adhm.202401218,"[100.0, 1260.0, 587.0, 1300.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False 1,11,text,"although similar in composition, exhibit distinct porosity and mechanical responses, with cortical bone showing linear elasticity due to its homogeneity and anisotropy, whereas cancellous bone display","[605.0, 1027.0, 1098.0, 1136.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,12,footnote,"© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, whic","[95.0, 1303.0, 585.0, 1412.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2024 The Author(s). Advanced Healthcare Materials publishe""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False @@ -27,40 +27,45 @@ A. S. Rizkalla, K. 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Anisotropic characteristics of natural tissues: a) the wave-like arrangement of collagen fibers within a rabbit's thoracic aorta subjected to 80 mmHg pressure. $ ^{[12]} $ b) quasistatic and,"[89.0, 950.0, 1095.0, 1276.0]",figure_caption,0.92,"[""figure_title label: Figure 1. Anisotropic characteristics of natural tissues: a)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 2,12,text,"and mechanical attributes of the aforementioned human tissues requires a combination of materials, as a single material alone cannot meet all these complex requirements. Thus, composite biomaterials p","[89.0, 1310.0, 582.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,13,text,,"[599.0, 1310.0, 1093.0, 1444.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,13,text,"mer/bioactive filler composites, polymer/polymer filler compos- +ites, polymer/metal filler composites, and bioactive glass/carbon +filler composites. Each category provides unique benefits, aiding +in achiev","[599.0, 1310.0, 1093.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,14,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93.0, 1487.0, 336.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False -2,15,footer,2401218 (2 of 20),"[391.0, 1484.0, 525.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +2,15,footer,2401218 (2 of 20),"[391.0, 1484.0, 525.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False 2,16,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[581.0, 1487.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False -2,17,aside_text,"2022659, 2024, 27, Downloaded from https://advancedonlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditions","[1155.0, 30.0, 1172.0, 1534.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,none,False,True +2,17,aside_text,"2022659, 2024, 27, Downloaded from https://advancedonlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditions","[1155.0, 30.0, 1172.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False 3,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[98.0, 45.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 3,1,header,"ADVANCED HEALTHCARE MATERIALS advhealthmat.de","[967.0, 40.0, 1096.0, 115.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -3,2,image,,"[99.0, 141.0, 1092.0, 653.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -3,3,figure_title,Figure 2. A rationale for nature-inspired tissue-mimicking biomaterial design strategy.,"[96.0, 669.0, 673.0, 691.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 2. A rationale for nature-inspired tissue-mimicking b""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +3,2,image,,"[99.0, 141.0, 1092.0, 653.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,Figure 2. A rationale for nature-inspired tissue-mimicking biomaterial design strategy.,"[96.0, 669.0, 673.0, 691.0]",figure_caption,0.92,"[""figure_title label: Figure 2. A rationale for nature-inspired tissue-mimicking b""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 3,4,text,"and durability, coupled with the flexibility of polymers. $ ^{[1]} $ On the other hand, polymer-carbon nanomaterial composites leverage the unique electrical and thermal properties of carbon nanomater","[95.0, 717.0, 587.0, 960.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,5,text,This review provides a comprehensive discussion of the advancements across the entire spectrum of composite biomaterials used as functional systems to restore or regenerate tissues. Our aim is to offe,"[95.0, 960.0, 587.0, 1161.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,6,paragraph_title,2. Native Tissue-mimicking Composite Biomaterials,"[96.0, 1183.0, 471.0, 1232.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Native Tissue-mimicking Composite Biomaterials""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True 3,7,text,The quest to emulate the intricate composite nature of biological tissues in regenerative medicine pivots on developing functional composite biomaterials. These biomaterials stand out due to their non,"[95.0, 1245.0, 587.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,8,text,,"[605.0, 718.0, 1097.0, 784.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +3,8,text,"we aim to create materials that replicate the complex microarchi- +tecture of biological systems, which is pivotal for the engineering +of effective tissue constructs.[14–16]","[605.0, 718.0, 1097.0, 784.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,9,text,Composite biomaterials are particularly significant in this context because they inherently possess the capability to imitate the composite structure of tissues. These materials offer a dual advantage,"[604.0, 785.0, 1098.0, 1268.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,10,text,"In their versatility, composite biomaterials excel at adapting to the varying mechanical attributes among different tissues and within the same tissue type. When scrutinized against single-material co","[604.0, 1267.0, 1098.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,11,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98.0, 1487.0, 342.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 3,12,footer,2401218 (3 of 20),"[396.0, 1484.0, 531.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False 3,13,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False -3,14,aside_text,"2022659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Condition","[1155.0, 31.0, 1171.0, 1535.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +3,14,aside_text,"2022659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Condition","[1155.0, 31.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 4,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False @@ -69,54 +74,56 @@ advhealthmat.de","[967.0, 39.0, 1090.0, 112.0]",noise,0.9,"[""header label""]",n 4,2,header,www.advhealthmat.de,"[919.0, 97.0, 1091.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 4,3,text,"responses to composite biomaterials also tend to be more favorable, as they usually foster more positive cellular activities such as adhesion, proliferation, and differentiation and present a reduced ","[90.0, 149.0, 581.0, 237.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,4,text,"From the engineering standpoint, designing and manufacturing composite biomaterials involves complex processes that may be more costly. Nevertheless, the outstanding performance and the ability for pr","[90.0, 237.0, 582.0, 436.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,5,paragraph_title,3. Composite biomaterials for bone repair and regeneration,"[91.0, 459.0, 534.0, 544.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Composite biomaterials for bone repair and regeneration 3"", ""split merged heading: kept '3. Composite biomaterials for bone repair and rege...'""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True -4,5,paragraph_title,3.1. The materials nexus,"[91.0, 459.0, 534.0, 544.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3. Composite biomaterials for bone repair and regeneration 3"", ""split from merged heading: extracted '3.1. 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HA has been steadily incorporated into biomat,"[90.0, 1356.0, 582.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,10,text,,"[598.0, 148.0, 1093.0, 741.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,10,text,"been coated onto prosthetic metal implants to promote bone +integration.[32] Accordingly, it has been found that the use of +iron-reinforced hydroxyapatite nanorods, combined with colla- +gen/polycaprola","[598.0, 148.0, 1093.0, 741.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,11,text,Mg/poly(Lactic acid) (PLA) composites can potentially replace traditional non-degradable metallic implants for long-bone fractures. 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Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155.0, 32.0, 1171.0, 1536.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 6,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False @@ -124,7 +131,10 @@ www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header l 6,2,header,www.advhealthmat.de,"[919.0, 97.0, 1091.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,3,text,"tricalcium phosphate, $ [40,41] $ or bioactive glass. $ [20,42] $ While softer alternatives like polymer meshes, hydrogels, $ [43] $ and collagen sponges $ [44] $ or foams exist, they often lack the n","[89.0, 148.0, 582.0, 589.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,4,text,Composite biomaterials designed for non-load-bearing bone defects frequently found in cranial bones and smaller bones require a different approach. The lower mechanical stress experienced by these bon,"[89.0, 587.0, 582.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -6,5,text,,"[599.0, 149.0, 1092.0, 477.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +6,5,text,"approximately 200 μm/day,[54] this slow pace can result in oxy- +gen and nutrient deficiencies in large bone defects, increasing +the risk of graft failure. Soft substrates, such as fibrin gel, pro- +mote ","[599.0, 149.0, 1092.0, 477.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,6,text,"Conversely, cell-free scaffolds depend on tissue-resident cell migration, which is less effective and slower. Thus, while both scaffold types improve oxygen and nutrient delivery, cell-loaded fibrin g","[600.0, 478.0, 1092.0, 631.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,7,text,Research revealed that the development of composite hydrogels containing GelMA and Li-modified bioglass (GM/M-Li) served as a significant advancement in treating diabetic bone defects. These hydrogels,"[599.0, 631.0, 1093.0, 1029.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,8,paragraph_title,3.2. The signaling nexus,"[602.0, 1071.0, 790.0, 1094.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. The signaling nexus""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True @@ -133,24 +143,27 @@ www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header l 6,11,footer,"Adv. 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Clinical needPractical applicationRecent advancesReferences
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Clinical needPractical applicationRecent advancesReferences
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Different clinical scenarios require biomaterials wit","[95.0, 1377.0, 588.0, 1444.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -7,7,text,,"[604.0, 520.0, 1099.0, 963.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +7,7,text,"als with specific properties to ensure optimal bone repair and re- +generation. Mechanical strength and durability are necessary for +load-bearing bone defects caused by trauma or osteoporotic frac- +ture","[604.0, 520.0, 1099.0, 963.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,8,paragraph_title,4. Composite biomaterials for articular cartilage repair,"[606.0, 985.0, 1065.0, 1037.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Composite biomaterials for articular cartilage repair""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True 7,9,text,"Osteoarthritis (OA) is a chronic condition impacting millions worldwide, making it a leading cause of disability. The pathogenesis, although still not entirely understood, can be traced to a variety o","[604.0, 1048.0, 1099.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,10,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98.0, 1487.0, 342.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 7,11,footer,2401218 (7 of 20),"[396.0, 1484.0, 531.0, 1508.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False 7,12,footer,© 2024 The Author(s). 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See the Terms and Conditio","[1155.0, 30.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 8,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False @@ -159,13 +172,16 @@ www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header l 8,3,text,"the potential of biodegradable alternatives. Essentially, piezoelectric materials convert mechanical stress into electrical energy and vice versa. Classic piezoelectric materials include lead zirconat","[89.0, 149.0, 582.0, 567.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,4,text,"Biodegradable piezoelectric nanofibers like PLLA, used in conjunction with physical activity, have demonstrated potential in cartilage regeneration. $ ^{[66]} $ The in-vivo results indicated that piez","[89.0, 565.0, 582.0, 1334.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,5,text,"Innovatively, injectable hydrogels have drawn much attention in cartilage regeneration. The novel design of nanofiber composite microchannel-containing hydrogels inspired by the tunnel-piled structure","[89.0, 1332.0, 582.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,6,text,,"[599.0, 150.0, 1093.0, 544.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,6,text,"tosan (APA/CMCS) hydrogels, thermosensitive gelatin mi- +crorods (GMs) act as a pore-forming agent, and coaxial +electrospinning polylactic acid/gelatin fibers (PGFs) loaded +with kartogenin (KGN) functio","[599.0, 150.0, 1093.0, 544.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,7,text,"Continuing with the theme of regenerative strategies, the use of viscoelastic hydrogels for chondrocyte culture and the creation of self-healing materials have come into focus. The former promotes a n","[598.0, 544.0, 1093.0, 1026.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,8,text,"Administering therapeutics via intra-articular injection proves to be an effective method for treating OA. Accordingly, an injectable hydrogel integrated with liposome-anchored teriparatide is another","[598.0, 1027.0, 1093.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,9,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93.0, 1487.0, 336.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 8,10,footer,2401218 (8 of 20),"[391.0, 1483.0, 526.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False 8,11,footer,© 2024 The Author(s). 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Thus, wearable ultrasonic devices and soft, stretchable elastomers are emerging as promi","[89.0, 1048.0, 582.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,6,text,,"[598.0, 149.0, 1092.0, 521.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,6,text,"the dynamic examination of the left ventricle, promoting compre- +hensive cardiac monitoring.[102] Additionally, the quest for con- +ductive, stretchable, and biocompatible materials for wearable +and im","[598.0, 149.0, 1092.0, 521.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,7,text,"While considerable progress has been made in cardiac tissue engineering using composite biomaterials, creating functional cardiac tissue with controlled cell orientation, mechanical anisotropy, and hi","[599.0, 522.0, 1093.0, 764.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,8,paragraph_title,6. 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See the Terms and Conditio","[1154.0, 29.0, 1172.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 12,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False @@ -230,14 +248,17 @@ advhealthmat.de","[966.0, 39.0, 1091.0, 115.0]",noise,0.9,"[""header label""]",n 12,3,text,"host tissues, making the hydrogels biomimetic. Furthermore, by selecting suitable polymeric components and adjusting moisture content, the mechanical characteristics of hydrogels, such as modulus, may","[89.0, 149.0, 581.0, 303.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,4,text,There are several fabrication strategies for conductive hydrogels for tissue engineering and regenerative medicine. The versatility of hydrogel fabrication which is attributed to the diverse gelation ,"[89.0, 302.0, 582.0, 850.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,5,text,"Native tissues are responsive to a variety of mechanical stimuli, such as stretching, compression, and shear forces. To retain structural integrity and usefulness, hydrogels utilized in tissue enginee","[90.0, 851.0, 582.0, 1314.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -12,6,text,,"[598.0, 148.0, 1093.0, 675.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +12,6,text,"pGO-PAM hydrogel, composed of Polydopamine (PDA), partially +reduced Graphene Oxide (pGO), and Polyacrylamide (PAM), +was successfully synthesized through a three-step process.[154] +Dopamine was initial","[598.0, 148.0, 1093.0, 675.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,7,text,"Although hydrogels offer enormous promise for biomedical applications, their implantable uses are constrained since hydrogels eventually swell under physiological conditions, resulting in considerable","[599.0, 675.0, 1093.0, 1026.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,8,text,"The rationale behind design strategies for electroconductive porous composite scaffolds is to create a biomaterial that can mimic the electrical properties of native tissues and support cell growth, d","[598.0, 1025.0, 1093.0, 1314.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,9,footnote,compression (right).[95] i) Transplantation of the composite onto a pig's heart.[95] j) Immunostaining of cardiac-specific proteins (α-actinin and CX-43) in RCMs cultured in various scaffolds for 7 da,"[89.0, 1363.0, 1095.0, 1443.0]",footnote,0.7,"[""footnote label: compression (right).[95] i) Transplantation of the composite""]",footnote,0.7,body_zone,body_like,none,True,True 12,10,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93.0, 1487.0, 337.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 12,11,footer,2401218 (12 of 20),"[386.0, 1484.0, 530.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False 12,12,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[580.0, 1487.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False -12,13,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. 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These films have potential applications in various fields, such as electronic devices, sensors, energy storage","[95.0, 895.0, 588.0, 1423.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -13,6,text,,"[605.0, 149.0, 1097.0, 192.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +13,6,text,"ity and superior tensile modulus compared to pure silk fibroin +matrices.[164]","[605.0, 149.0, 1097.0, 192.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,7,text,"Composite films made of graphene oxide (GO) and either polypyrrole (PPy-GO) or PEDOT-GO were examined for their cytocompatibility with cardiomyocytes and neural progenitors. $ ^{[165]} $ However, usin","[604.0, 193.0, 1098.0, 654.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,8,text,"Adding ceramic to polymers can have both positive and negative effects on their properties, but few studies have directly compared the effects of different types of inorganic additives. A comparison o","[605.0, 654.0, 1098.0, 1048.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,9,text,"Conductive polymers and organic/inorganic composites may be molded into various shapes and forms, and because they are flexible, they can also be utilized as wearable bioelectronic materials. Nanopart","[604.0, 1048.0, 1099.0, 1424.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,10,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98.0, 1487.0, 342.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 13,11,footer,2401218 (13 of 20),"[392.0, 1484.0, 536.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False 13,12,footer,© 2024 The Author(s). 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See the Terms and Conditio","[1155.0, 30.0, 1171.0, 1534.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 14,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[92.0, 46.0, 339.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False @@ -266,14 +288,17 @@ advhealthmat.de","[967.0, 39.0, 1091.0, 114.0]",noise,0.9,"[""header label""]",n 14,5,paragraph_title,6.3. Magnetic and composite biomaterials,"[90.0, 850.0, 411.0, 873.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.3. Magnetic and composite biomaterials""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True 14,6,text,Magnetic nanoparticles (MNPs) are one of the most significant categories of nanomaterials studied for potential use in nanomedicine. Using MNPs allows the creation of soft composite biomaterials for v,"[90.0, 894.0, 582.0, 1246.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True 14,7,text,"As an alternative to electric fields and acoustic waves, cardiac tissue engineering can incorporate magnetic hydrogel components to mimic the physical and biological organization of cardiac tissues an","[89.0, 1246.0, 583.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True -14,8,text,,"[598.0, 147.0, 1094.0, 741.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,body_like,empty,False,True +14,8,text,"sis and improve cardiac function in infarcted cardiac tissue.[178] +The magnetic nanoparticles consisted of a Fe3O4 core and a sil- +ica shell, decorated with poly (ethylene glycol) and two types of +ant","[598.0, 147.0, 1094.0, 741.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True 14,9,text,"Neural tissue, which is responsible for the transmission of nerve impulses within the nervous system, primarily consists of neurons possessing a cell body, axons, and dendrites. 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Composite biomaterials for therapeutic drug delivery""]",section_heading,0.85,reference_zone,reference_like,reference_numeric_dot,False,True 14,11,text,"Composite biomaterials possess key features, including tunability, improved performance (mechanical properties, biocompatibility, and controlled release profile), and versatility that make them good c","[599.0, 1354.0, 1094.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True 14,12,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[92.0, 1487.0, 337.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False 14,13,footer,2401218 (14 of 20),"[385.0, 1483.0, 529.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False 14,14,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[580.0, 1486.0, 1091.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False -14,15,aside_text,"21922659, 2024, 27. Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05(02/2026)]. See the Terms and Conditi","[1155.0, 30.0, 1171.0, 1540.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +14,15,aside_text,"21922659, 2024, 27. Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05(02/2026)]. See the Terms and Conditi","[1155.0, 30.0, 1171.0, 1540.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 15,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[98.0, 46.0, 345.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False @@ -282,14 +307,17 @@ advhealthmat.de","[973.0, 39.0, 1096.0, 115.0]",noise,0.9,"[""header label""]",n 15,2,header,www.advhealthmat.de,"[925.0, 98.0, 1097.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False 15,3,text,composite biomaterials in drug delivery and tissue engineering is becoming increasingly frequent owing to their superior performance. $ ^{[182]} $ When designing composite biomaterials for drug delive,"[95.0, 149.0, 588.0, 391.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True 15,4,text,"To enhance the bioactivity of the drug, several factors need to be considered, including the use of protective carriers, drug loading, and release modifications, incorporation of bioactive materials s","[95.0, 391.0, 589.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True -15,5,text,,"[604.0, 149.0, 1098.0, 413.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,body_like,empty,False,True +15,5,text,"efficiency for tissue engineering and other biomedical applica- +tions. Bioactive glass (BG) nanoparticles (BGNs) and hydrogels +have emerged as promising systems for drug delivery.[193] BGNs, +owing to th","[604.0, 149.0, 1098.0, 413.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True 15,6,text,"Moving forward, hybrid drug delivery systems that combine two or more drug delivery methods have the potential to maintain drug bioactivity. It has been shown that combining a nanoparticle drug delive","[604.0, 410.0, 1099.0, 1204.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True 15,7,paragraph_title,8. Conclusions and Future Directions,"[607.0, 1229.0, 967.0, 1254.0]",section_heading,0.85,"[""paragraph_title label with numbering: 8. Conclusions and Future Directions""]",section_heading,0.85,,heading_like,heading_numbered,True,True 15,8,text,"The field of composite biomaterials is continuously evolving, and researchers are investigating various directions to enhance their properties and expand their applications. The versatile nature of co","[605.0, 1267.0, 1099.0, 1446.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True 15,9,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98.0, 1487.0, 342.0, 1505.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False 15,10,footer,2401218 (15 of 20),"[392.0, 1484.0, 535.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False 15,11,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False -15,12,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155.0, 29.0, 1171.0, 1533.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +15,12,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155.0, 29.0, 1171.0, 1533.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 16,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[92.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False @@ -304,13 +332,13 @@ advhealthmat.de","[966.0, 40.0, 1091.0, 115.0]",noise,0.9,"[""header label""]",n 16,8,text,V) Multifunctional composite systems. The future will see the development of composite biomaterials that combine multiple functionalities within a single material system. These multifunctional composi,"[100.0, 1044.0, 581.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 16,9,paragraph_title,Keywords,"[603.0, 149.0, 701.0, 175.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Keywords""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 16,10,text,The authors declare no conflict of interest.,"[92.0, 1422.0, 377.0, 1442.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True -16,11,text,"bone tissue, cardiac tissue, cartilage tissue, composite biomaterials, electrical conductivity, magnetic stimulation, nerve tissue","[600.0, 186.0, 1090.0, 227.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -16,12,text,"Revised: June 13, 2024","[938.0, 268.0, 1091.0, 286.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,11,text,"bone tissue, cardiac tissue, cartilage tissue, composite biomaterials, electrical conductivity, magnetic stimulation, nerve tissue","[600.0, 186.0, 1090.0, 227.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,12,text,"Revised: June 13, 2024","[938.0, 268.0, 1091.0, 286.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 16,13,text,"Received: April 1, 2024","[937.0, 248.0, 1091.0, 267.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False -16,14,paragraph_title,Conflict of Interest,"[92.0, 1384.0, 275.0, 1409.0]",unknown_structural,0.5,"[""backmatter heading on page 16: Conflict of Interest""]",backmatter_heading_candidate,0.8,,support_like,none,False,True +16,14,paragraph_title,Conflict of Interest,"[92.0, 1384.0, 275.0, 1409.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True 16,15,text,"Published online: July 22, 2024","[883.0, 287.0, 1090.0, 307.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False -16,16,paragraph_title,Acknowledgements,"[92.0, 1275.0, 284.0, 1300.0]",backmatter_heading,0.8,"[""backmatter heading on page 16: Acknowledgements""]",backmatter_heading_candidate,0.8,,heading_like,short_fragment,True,True -16,17,text,This research was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC) Grant # RGPIN2018-06310.,"[90.0, 1311.0, 580.0, 1352.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,16,paragraph_title,Acknowledgements,"[92.0, 1275.0, 284.0, 1300.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +16,17,text,This research was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC) Grant # RGPIN2018-06310.,"[90.0, 1311.0, 580.0, 1352.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 16,18,reference_content,"[1] A. Skorulska, P. Piszko, Z. Rybak, M. Szymonowicz, M. Dobrzyński, Materials 1592, 14, 2021.","[620.0, 386.0, 1090.0, 425.0]",reference_item,0.85,"[""reference content label: [1] A. Skorulska, P. Piszko, Z. Rybak, M. Szymonowicz, M. Do""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 16,19,reference_content,"[2] S. Agarwala, G. L. Goh, G. D. Goh, V. Dikshit, W. Y. Yeong, 3D and 4D Printing of Polymer Nanocomposite Materials: Processes, Applications, and Challenges, pp. 297–324, 2020.","[620.0, 427.0, 1090.0, 485.0]",reference_item,0.85,"[""reference content label: [2] S. Agarwala, G. L. Goh, G. D. Goh, V. Dikshit, W. Y. Yeo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 16,20,reference_content,"[3] C. Ma, T. Du, X. Niu, Y. Fan, Bone Res. 2022, 10, https://doi.org/10.1038/s41413-022-00223-y.","[620.0, 487.0, 1089.0, 524.0]",reference_item,0.85,"[""reference content label: [3] C. Ma, T. Du, X. Niu, Y. 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See the Terms and Condition","[1156.0, 33.0, 1171.0, 1536.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +17,64,aside_text,"21922659, 2024, 27, Downloaded from https://advancedonlinelibrary.wiley.com/doi/10.1002/adfm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Condition","[1156.0, 33.0, 1171.0, 1536.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 18,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[90.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False @@ -468,7 +496,7 @@ www.advancedsciencenews.com","[90.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header l 18,57,footer,"Adv. 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See the Terms and Condition","[1156.0, 33.0, 1171.0, 1536.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +18,60,aside_text,"21922659, 2024, 27, Downloaded from https://advancedonlinelibrary.wiley.com/doi/10.1002/adfm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Condition","[1156.0, 33.0, 1171.0, 1536.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 19,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[98.0, 46.0, 344.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False @@ -530,7 +558,7 @@ www.advancedsciencenews.com","[98.0, 46.0, 344.0, 116.0]",noise,0.9,"[""header l 19,56,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[99.0, 1488.0, 342.0, 1504.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False 19,57,footer,2401218 (19 of 20),"[392.0, 1484.0, 535.0, 1507.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False 19,58,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586.0, 1487.0, 1097.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False -19,59,aside_text,"2022659, 2024, 27, Downloaded from https://advancedonlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditions","[1156.0, 32.0, 1171.0, 1535.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +19,59,aside_text,"2022659, 2024, 27, Downloaded from https://advancedonlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditions","[1156.0, 32.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 20,0,header,"ADVANCED SCIENCE NEWS www.advancedsciencenews.com","[93.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False @@ -553,8 +581,8 @@ www.advancedsciencenews.com","[93.0, 46.0, 339.0, 116.0]",noise,0.9,"[""header l 20,17,image,,"[114.0, 749.0, 314.0, 1007.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True 20,18,vision_footnote,Amin S. Rizkalla is a professor at Western University in Schulich Dentistry; Chemical and Biochemical Engineering; Medical Biophysics; and Biomedical Engineering. His research area is in dental and or,"[326.0, 748.0, 1070.0, 903.0]",footnote,0.7,"[""vision_footnote label: Amin S. Rizkalla is a professor at Western University in Sch""]",footnote,0.7,reference_zone,reference_like,citation_line,True,True 20,19,image,,"[113.0, 1036.0, 315.0, 1293.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True -20,20,text,"Kibret Mequanint is a Professor in the Department of Chemical and Biochemical Engineering and the School of Biomedical Engineering at the University of Western Ontario, Canada. His research interests ","[326.0, 1032.0, 1069.0, 1232.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +20,20,text,"Kibret Mequanint is a Professor in the Department of Chemical and Biochemical Engineering and the School of Biomedical Engineering at the University of Western Ontario, Canada. His research interests ","[326.0, 1032.0, 1069.0, 1232.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 20,21,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93.0, 1488.0, 336.0, 1504.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False 20,22,footer,2401218 (20 of 20),"[387.0, 1485.0, 528.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False 20,23,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[582.0, 1488.0, 1090.0, 1506.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False -20,24,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1156.0, 31.0, 1171.0, 1535.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +20,24,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1156.0, 31.0, 1171.0, 1535.0]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False diff --git a/audit/K7R8PEKW/changed_blocks_after_fallback.json b/audit/K7R8PEKW/changed_blocks_after_fallback.json index 855e6837..ff6b438d 100644 --- a/audit/K7R8PEKW/changed_blocks_after_fallback.json +++ b/audit/K7R8PEKW/changed_blocks_after_fallback.json @@ -178,7 +178,7 @@ { "block_id": "p2:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -187,7 +187,7 @@ { "block_id": "p2:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -196,7 +196,7 @@ { "block_id": "p2:5", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -205,7 +205,7 @@ { "block_id": "p2:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -214,7 +214,7 @@ { "block_id": "p2:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -223,7 +223,7 @@ { "block_id": "p2:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -232,7 +232,7 @@ { "block_id": "p2:9", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -241,7 +241,7 @@ { "block_id": "p2:10", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -331,7 +331,7 @@ { "block_id": "p5:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -340,7 +340,7 @@ { "block_id": "p5:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -358,7 +358,7 @@ { "block_id": "p5:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -367,7 +367,7 @@ { "block_id": "p5:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -376,7 +376,7 @@ { "block_id": "p5:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -385,7 +385,7 @@ { "block_id": "p5:9", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -394,7 +394,7 @@ { "block_id": "p5:10", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -403,7 +403,7 @@ { "block_id": "p5:11", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -412,7 +412,7 @@ { "block_id": "p5:12", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -421,7 +421,7 @@ { "block_id": "p5:13", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -430,7 +430,7 @@ { "block_id": "p5:14", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -439,7 +439,7 @@ { "block_id": "p5:15", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -448,7 +448,7 @@ { "block_id": "p5:16", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -466,7 +466,7 @@ { "block_id": "p5:18", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -475,7 +475,7 @@ { "block_id": "p5:19", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -493,7 +493,7 @@ { "block_id": "p5:21", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -502,7 +502,7 @@ { "block_id": "p5:22", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -511,7 +511,7 @@ { "block_id": "p5:23", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -520,7 +520,7 @@ { "block_id": "p5:24", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -529,7 +529,7 @@ { "block_id": "p5:25", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -538,7 +538,7 @@ { "block_id": "p5:26", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -664,7 +664,7 @@ { "block_id": "p11:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -673,7 +673,7 @@ { "block_id": "p11:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -691,7 +691,7 @@ { "block_id": "p11:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -700,7 +700,7 @@ { "block_id": "p11:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -709,7 +709,7 @@ { "block_id": "p11:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -718,7 +718,7 @@ { "block_id": "p11:9", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -727,7 +727,7 @@ { "block_id": "p11:10", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -736,7 +736,7 @@ { "block_id": "p11:11", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -745,7 +745,7 @@ { "block_id": "p11:12", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -754,7 +754,7 @@ { "block_id": "p11:13", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -763,7 +763,7 @@ { "block_id": "p11:14", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -772,7 +772,7 @@ { "block_id": "p11:15", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, diff --git a/audit/K7R8PEKW/coverage_check.json b/audit/K7R8PEKW/coverage_check.json index d6c9971a..cc435c43 100644 --- a/audit/K7R8PEKW/coverage_check.json +++ b/audit/K7R8PEKW/coverage_check.json @@ -2,38 +2,19 @@ "paper_key": "K7R8PEKW", "mode": "high-risk", "required_block_ids": [ - "p10:14", - "p10:6", "p11:10", "p11:11", "p11:12", "p11:13", "p11:14", "p11:15", - "p11:16", - "p11:20", "p11:3", "p11:4", - "p11:5", "p11:6", "p11:7", "p11:8", "p11:9", - "p12:13", - "p12:6", - "p13:13", - "p13:3", - "p13:6", - "p14:10", - "p14:13", - "p14:15", - "p14:8", - "p15:10", - "p15:12", - "p15:5", "p16:10", - "p16:11", - "p16:12", "p16:13", "p16:14", "p16:15", @@ -65,7 +46,6 @@ "p16:40", "p16:41", "p16:43", - "p16:45", "p16:5", "p16:6", "p16:7", @@ -99,7 +79,6 @@ "p20:19", "p20:20", "p20:22", - "p20:24", "p20:3", "p20:4", "p20:5", @@ -108,10 +87,6 @@ "p20:8", "p20:9", "p2:10", - 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Downloaded from https://advanced.onlinelibrary.wiley.com/doi", @@ -680,8 +660,18 @@ "zone": "body_zone", "render_default": true, "snippet": "Composite biomaterials designed for non-load-bearing bone defects frequently fou", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p6:5", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "approximately 200 μm/day,[54] this slow pace can result in oxy- gen and nutrient", "found_in_fulltext": true, - "fulltext_offset": 17819 + "fulltext_offset": 16167 }, { "block_id": "p6:6", @@ -691,7 +681,7 @@ "render_default": true, "snippet": "Conversely, cell-free scaffolds depend on tissue-resident cell migration, which ", "found_in_fulltext": true, - "fulltext_offset": 21269 + "fulltext_offset": 17172 }, { "block_id": "p6:7", @@ -701,7 +691,7 @@ "render_default": true, "snippet": "Research revealed that the development of composite hydrogels containing GelMA a", "found_in_fulltext": true, - "fulltext_offset": 21664 + "fulltext_offset": 17567 }, { "block_id": "p6:8", @@ -711,7 +701,7 @@ "render_default": true, "snippet": "3.2. 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Clinical needPractical applicationRecent advanc", + "snippet": "Table 1. Clinical needs, applications, and exemplary recent advances in bone tis", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -821,7 +811,7 @@ "render_default": true, "snippet": "main mechanisms.[56] First, metal ions, especially calcium, influence signaling ", "found_in_fulltext": true, - "fulltext_offset": 23754 + "fulltext_offset": 19657 }, { "block_id": "p7:6", @@ -831,7 +821,17 @@ "render_default": true, "snippet": "Not surprisingly, addressing the multifaceted clinical needs is essential for de", "found_in_fulltext": true, - "fulltext_offset": 26176 + "fulltext_offset": 22079 + }, + { + "block_id": "p7:7", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "als with specific properties to ensure optimal bone repair and re- generation. Me", + "found_in_fulltext": true, + "fulltext_offset": 23553 }, { "block_id": "p7:8", @@ -841,7 +841,7 @@ "render_default": true, "snippet": "4. Composite biomaterials for articular cartilage repair", "found_in_fulltext": true, - "fulltext_offset": 27653 + "fulltext_offset": 24848 }, { "block_id": "p7:9", @@ -851,7 +851,7 @@ "render_default": true, "snippet": "Osteoarthritis (OA) is a chronic condition impacting millions worldwide, making ", "found_in_fulltext": true, - "fulltext_offset": 27710 + "fulltext_offset": 24905 }, { "block_id": "p7:10", @@ -886,7 +886,7 @@ { "block_id": "p7:13", "page": 7, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "21922659, 2024, 27. Downloaded from https://advanced.onlinelibrary.wiley.com/doi", @@ -930,8 +930,8 @@ "zone": "body_zone", "render_default": true, "snippet": "the potential of biodegradable alternatives. Essentially, piezoelectric material", - "found_in_fulltext": true, - "fulltext_offset": 28921 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:4", @@ -940,8 +940,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Biodegradable piezoelectric nanofibers like PLLA, used in conjunction with physi", - "found_in_fulltext": true, - "fulltext_offset": 30124 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:5", @@ -951,7 +951,17 @@ "render_default": true, "snippet": "Innovatively, injectable hydrogels have drawn much attention in cartilage regene", "found_in_fulltext": true, - "fulltext_offset": 32355 + "fulltext_offset": 26116 + }, + { + "block_id": "p8:6", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "tosan (APA/CMCS) hydrogels, thermosensitive gelatin mi- crorods (GMs) act as a p", + "found_in_fulltext": true, + "fulltext_offset": 27497 }, { "block_id": "p8:7", @@ -961,7 +971,7 @@ "render_default": true, "snippet": "Continuing with the theme of regenerative strategies, the use of viscoelastic hy", "found_in_fulltext": true, - "fulltext_offset": 33736 + "fulltext_offset": 28647 }, { "block_id": "p8:8", @@ -971,7 +981,7 @@ "render_default": true, "snippet": "Administering therapeutics via intra-articular injection proves to be an effecti", "found_in_fulltext": true, - "fulltext_offset": 35158 + "fulltext_offset": 30069 }, { "block_id": "p8:9", @@ -1006,7 +1016,7 @@ { "block_id": "p8:12", "page": 8, - "role": "unknown_structural", + "role": "noise", "zone": "body_zone", "render_default": false, "snippet": "21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi", @@ -1050,8 +1060,8 @@ "zone": "body_zone", "render_default": true, "snippet": "capacity to self-renew hydration layers, thereby minimizing friction and maintai", - "found_in_fulltext": true, - "fulltext_offset": 36322 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p9:4", @@ -1060,8 +1070,8 @@ "zone": "body_zone", "render_default": true, "snippet": "The aging population's increasing pain and disability underscore the need for un", - "found_in_fulltext": true, - "fulltext_offset": 38373 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p9:5", @@ -1071,7 +1081,7 @@ "render_default": true, "snippet": "5. 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Downloaded from https://advanced.onlinelibrary.wiley.com/doi", @@ -1650,8 +1670,8 @@ "zone": "", "render_default": true, "snippet": "been investigated.[168] To address the issue of IR- and thermal radiation-shield", - "found_in_fulltext": true, - "fulltext_offset": 64941 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p14:4", @@ -1660,8 +1680,8 @@ "zone": "", "render_default": true, "snippet": "The functioning of various organs and systems is dependent on the nervous system", - "found_in_fulltext": true, - "fulltext_offset": 65587 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p14:5", @@ -1671,7 +1691,7 @@ "render_default": true, "snippet": "6.3. 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The future will see the development of com", "found_in_fulltext": true, - "fulltext_offset": 81507 + "fulltext_offset": 64060 }, { "block_id": "p16:9", @@ -1981,7 +2021,7 @@ "render_default": true, "snippet": "Keywords", "found_in_fulltext": true, - "fulltext_offset": 82179 + "fulltext_offset": 64732 }, { "block_id": "p16:10", @@ -1991,33 +2031,33 @@ "render_default": true, "snippet": "The authors declare no conflict of interest.", "found_in_fulltext": true, - "fulltext_offset": 82129 + "fulltext_offset": 64682 }, { "block_id": "p16:11", "page": 16, - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "render_default": true, "snippet": "bone tissue, cardiac tissue, cartilage tissue, composite biomaterials, electrica", "found_in_fulltext": true, - "fulltext_offset": 82188 + "fulltext_offset": 64741 }, { "block_id": "p16:12", "page": 16, - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "render_default": true, "snippet": "Revised: June 13, 2024", "found_in_fulltext": true, - "fulltext_offset": 82319 + "fulltext_offset": 64872 }, { "block_id": "p16:14", "page": 16, "role": "unknown_structural", - "zone": "", + "zone": "tail_nonref_hold_zone", "render_default": false, "snippet": "Conflict of Interest", "found_in_fulltext": false, @@ -2026,22 +2066,22 @@ { "block_id": "p16:16", "page": 16, - "role": "backmatter_heading", - "zone": "", + "role": "sub_subsection_heading", + "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Acknowledgements", "found_in_fulltext": true, - "fulltext_offset": 81985 + "fulltext_offset": 64538 }, { "block_id": "p16:17", "page": 16, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "This research was funded by the Natural Sciences and Engineering Research Counci", "found_in_fulltext": true, - "fulltext_offset": 82004 + "fulltext_offset": 64557 }, { "block_id": "p16:18", @@ -2051,7 +2091,7 @@ "render_default": true, "snippet": "[1] A. 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H. Ng, W. Y. Yeong, Y.-J. Kim, Y.-", "found_in_fulltext": true, - "fulltext_offset": 83899 + "fulltext_offset": 66452 }, { "block_id": "p16:31", @@ -2181,7 +2221,7 @@ "render_default": true, "snippet": "[14] R. Xie, H. Yao, A. S. Mao, Y. Zhu, D. Qi, Y. Jia, M. Gao, Y. Chen, L. Wang,", "found_in_fulltext": true, - "fulltext_offset": 84052 + "fulltext_offset": 66605 }, { "block_id": "p16:32", @@ -2191,7 +2231,7 @@ "render_default": true, "snippet": "[15] P. Ma, W. Wu, Y. Wei, L. Ren, S. Lin, J. Wu, Mater. Des. 2021, 207, 109865.", "found_in_fulltext": true, - "fulltext_offset": 84211 + "fulltext_offset": 66764 }, { "block_id": "p16:33", @@ -2201,7 +2241,7 @@ "render_default": true, "snippet": "[16] Y. Fang, T. Zhang, L. Zhang, W. Gong, W. Sun, Biofabrication 2019, 11, 0350", "found_in_fulltext": true, - "fulltext_offset": 84292 + "fulltext_offset": 66845 }, { "block_id": "p16:34", @@ -2211,7 +2251,7 @@ "render_default": true, "snippet": "[17] Y. Li, L. Huang, G. Tai, F. Yan, L. Cai, C. Xin, S. Al Islam, Compos Part A", "found_in_fulltext": true, - "fulltext_offset": 84376 + "fulltext_offset": 66929 }, { "block_id": "p16:35", @@ -2221,7 +2261,7 @@ "render_default": true, "snippet": "[18] L. Benedini, J. Laiuppa, G. Santillán, M. Baldini, P. Messina, Mater. Sci. ", "found_in_fulltext": true, - "fulltext_offset": 84494 + "fulltext_offset": 67047 }, { "block_id": "p16:36", @@ -2231,7 +2271,7 @@ "render_default": true, "snippet": "[19] A. Shapira, R. Feiner, T. Dvir, Int. Mater. Rev. 2016, 61, 1.", "found_in_fulltext": true, - "fulltext_offset": 84601 + "fulltext_offset": 67154 }, { "block_id": "p16:37", @@ -2241,7 +2281,7 @@ "render_default": true, "snippet": "[20] G. Turnbull, J. Clarke, F. Picard, P. Riches, L. Jia, F. Han, B. Li, W. Shu", "found_in_fulltext": true, - "fulltext_offset": 84668 + "fulltext_offset": 67221 }, { "block_id": "p16:38", @@ -2251,7 +2291,7 @@ "render_default": true, "snippet": "[21] E. Kon, F. Salamanna, G. Filardo, B. Di Matteo, N. Shabshin, J. Shani, M. F", "found_in_fulltext": true, - "fulltext_offset": 84779 + "fulltext_offset": 67332 }, { "block_id": "p16:39", @@ -2261,7 +2301,7 @@ "render_default": true, "snippet": "[22] J. A. Nicholson, N. Makaram, A. H. R. W. Simpson, J. F. Keating, Injury 202", "found_in_fulltext": true, - "fulltext_offset": 84973 + "fulltext_offset": 67526 }, { "block_id": "p16:40", @@ -2271,7 +2311,7 @@ "render_default": true, "snippet": "[23] Sci. Transl. Med. 2016, 8.", "found_in_fulltext": true, - "fulltext_offset": 85064 + "fulltext_offset": 67617 }, { "block_id": "p16:41", @@ -2281,7 +2321,7 @@ "render_default": true, "snippet": "[24] N. Egge, S. L. B. Arneaud, R. S. Fonseca, K. R. Zuurbier, J. McClendon, P. 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Zafaryab, M. A. Rizvi, S. Ahmad, Mater. Sci. Eng", "found_in_fulltext": true, - "fulltext_offset": 103444 + "fulltext_offset": 85001 }, { "block_id": "p19:33", @@ -3921,7 +3961,7 @@ "render_default": true, "snippet": "[167] M. Affi, M. K. Ahmed, A. M. Fathi, V. Uskoković, Int. J. Pharm. 2020, 585,", "found_in_fulltext": true, - "fulltext_offset": 103544 + "fulltext_offset": 85101 }, { "block_id": "p19:34", @@ -3931,7 +3971,7 @@ "render_default": true, "snippet": "[168] S.-M. Jeong, J. Ahn, Y. K. Choi, T. Lim, K. Seo, T. Hong, G. H. Choi, H. K", "found_in_fulltext": true, - "fulltext_offset": 103633 + "fulltext_offset": 85190 }, { "block_id": "p19:35", @@ -3941,7 +3981,7 @@ "render_default": true, "snippet": "[169] J. Park, S. Choi, A. H. Janardhan, S.-Y. Lee, S. Raut, J. Soares, K. Shin,", "found_in_fulltext": true, - "fulltext_offset": 103812 + "fulltext_offset": 85369 }, { "block_id": "p19:36", @@ -3951,7 +3991,7 @@ "render_default": true, "snippet": "[170] Z. Zhang, Y. Wang, Z. Chen, D. Xu, D. Zhang, F. Wang, Y. Zhao, J. Nanobiot", "found_in_fulltext": true, - "fulltext_offset": 104139 + "fulltext_offset": 85696 }, { "block_id": "p19:37", @@ -3961,7 +4001,7 @@ "render_default": true, "snippet": "[171] D. O. Adewole, M. D. Serruya, J. A. Wolf, D. K. Cullen, Front. Neurosci. 2", "found_in_fulltext": true, - "fulltext_offset": 104279 + "fulltext_offset": 85836 }, { "block_id": "p19:38", @@ -3971,7 +4011,7 @@ "render_default": true, "snippet": "[172] F. Lotti, F. Ranieri, G. Vadalà, L. Zollo, G. Di Pino, Front. Neurosci. 20", "found_in_fulltext": true, - "fulltext_offset": 104406 + "fulltext_offset": 85963 }, { "block_id": "p19:39", @@ -3981,7 +4021,7 @@ "render_default": true, "snippet": "[173] J. Maughan, P. J. Gouveia, J. G. Gonzalez, L. M. Leahy, I. Woods, C. O'Con", "found_in_fulltext": true, - "fulltext_offset": 104532 + "fulltext_offset": 86089 }, { "block_id": "p19:40", @@ -3991,7 +4031,7 @@ "render_default": true, "snippet": "[174] A. Pardo, M. Gómez-Florit, S. Barbosa, P. Taboada, R. M. A. Domingues, M. ", "found_in_fulltext": true, - "fulltext_offset": 104782 + "fulltext_offset": 86339 }, { "block_id": "p19:41", @@ -4001,7 +4041,7 @@ "render_default": true, "snippet": "[175] Y. Li, G. Huang, X. Zhang, B. Li, Y. Chen, T. Lu, T. J. Lu, F. Xu, Adv. Fu", "found_in_fulltext": true, - "fulltext_offset": 104896 + "fulltext_offset": 86453 }, { "block_id": "p19:42", @@ -4011,7 +4051,7 @@ "render_default": true, "snippet": "[176] R. Tognato, A. R. Armiento, V. Bonfrate, R. Levato, J. Malda, M. Alini, D.", "found_in_fulltext": true, - "fulltext_offset": 105003 + "fulltext_offset": 86560 }, { "block_id": "p19:43", @@ -4021,7 +4061,7 @@ "render_default": true, "snippet": "[177] L. Zwi-Dantsis, B. Wang, C. Marijon, S. Zonetti, A. Ferrini, L. Massi, D. ", "found_in_fulltext": true, - "fulltext_offset": 105179 + "fulltext_offset": 86736 }, { "block_id": "p19:44", @@ -4031,7 +4071,7 @@ "render_default": true, "snippet": "[178] S. Liu, X. Chen, L. Bao, T. Liu, P. Yuan, X. Yang, X. Qiu, J. J. Gooding, ", "found_in_fulltext": true, - "fulltext_offset": 105363 + "fulltext_offset": 86920 }, { "block_id": "p19:45", @@ -4041,7 +4081,7 @@ "render_default": true, "snippet": "[179] H.-F. Liang, Y.-P. Zou, A.-N. Hu, B. Wang, J. Li, L. Huang, W.-S. Chen, D.", "found_in_fulltext": true, - "fulltext_offset": 105508 + "fulltext_offset": 87065 }, { "block_id": "p19:46", @@ -4051,7 +4091,7 @@ "render_default": true, "snippet": "[180] W. J. Tyler, Nat. Rev. Neurosci. 2012, 13, 867.", "found_in_fulltext": true, - "fulltext_offset": 105725 + "fulltext_offset": 87282 }, { "block_id": "p19:47", @@ -4061,7 +4101,7 @@ "render_default": true, "snippet": "[181] A. Tay, A. Sohrabi, K. Poole, S. Seidlits, D. Di Carlo, Adv. Mater. 2018, ", "found_in_fulltext": true, - "fulltext_offset": 105779 + "fulltext_offset": 87336 }, { "block_id": "p19:48", @@ -4071,7 +4111,7 @@ "render_default": true, "snippet": "[182] M. Janmohammadi, Z. Nazemi, A. O. M. 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Zhong, Z. Zhang, Y. Huang, J.", "found_in_fulltext": true, - "fulltext_offset": 106361 + "fulltext_offset": 87918 }, { "block_id": "p19:53", @@ -4121,7 +4161,7 @@ "render_default": true, "snippet": "[187] K. Liang, R. Ricco, C. M. Doherty, M. J. Styles, S. Bell, N. Kirby, S. Mud", "found_in_fulltext": true, - "fulltext_offset": 106476 + "fulltext_offset": 88033 }, { "block_id": "p19:54", @@ -4131,7 +4171,7 @@ "render_default": true, "snippet": "[188] X. Mo, D. Zhang, K. Liu, X. Zhao, X. Li, W. Wang, Int. J. Mol. Sci. 2023, ", "found_in_fulltext": true, - "fulltext_offset": 106637 + "fulltext_offset": 88194 }, { "block_id": "p19:55", @@ -4141,7 +4181,7 @@ "render_default": true, "snippet": "[189] K. Hasanbegloo, S. Banihashem, B. Faraji Dizaji, S. Bybordi, N. 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Borg", - "found_in_fulltext": true, - "fulltext_offset": 109071 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p20:5", @@ -4241,7 +4281,7 @@ "render_default": true, "snippet": "[192] Y. Qu, B. Chu, K. Shi, X. Wei, P. Yang, M. Chen, M. Tang, S. Li, F. Wang, ", "found_in_fulltext": true, - "fulltext_offset": 109183 + "fulltext_offset": 90523 }, { "block_id": "p20:6", @@ -4251,7 +4291,7 @@ "render_default": true, "snippet": "[193] N. Aslankoohi, K. Mequanint, ACS Appl. Bio. Mater. 2020, 3, 3621.", "found_in_fulltext": true, - "fulltext_offset": 109332 + "fulltext_offset": 90672 }, { "block_id": "p20:7", @@ -4261,7 +4301,7 @@ "render_default": true, "snippet": "[194] X. He, Y. Ding, S. Duan, S. Luo, J. Song, C. Peng, Y. Tan, Q. Zeng, Y. Liu", "found_in_fulltext": true, - "fulltext_offset": 109404 + "fulltext_offset": 90744 }, { "block_id": "p20:8", @@ -4271,7 +4311,7 @@ "render_default": true, "snippet": "[195] M. Feng, G. Jiang, Y. Sun, U. E. Aharodnikau, K. E. Yunusov, T. Liu, Z. Ze", "found_in_fulltext": true, - "fulltext_offset": 109526 + "fulltext_offset": 90866 }, { "block_id": "p20:9", @@ -4281,7 +4321,7 @@ "render_default": true, "snippet": "[196] G. Jiang, B. Xu, J. Zhu, Y. Zhang, T. Liu, G. Song, Biomed. Phys. Eng. Exp", "found_in_fulltext": true, - "fulltext_offset": 109668 + "fulltext_offset": 91008 }, { "block_id": "p20:10", @@ -4291,7 +4331,7 @@ "render_default": true, "snippet": "[197] M. Gou, X. Qu, W. Zhu, M. Xiang, J. Yang, K. Zhang, Y. Wei, S. Chen, Nat. ", "found_in_fulltext": true, - "fulltext_offset": 109770 + "fulltext_offset": 91110 }, { "block_id": "p20:11", @@ -4301,7 +4341,7 @@ "render_default": true, "snippet": "[198] B. Xiao, E. Viennois, Q. Chen, L. Wang, M. K. Han, Y. Zhang, Z. Zhang, Y. ", "found_in_fulltext": true, - "fulltext_offset": 109900 + "fulltext_offset": 91240 }, { "block_id": "p20:12", @@ -4311,7 +4351,7 @@ "render_default": true, "snippet": "[199] Y. Zhang, J. Zhang, M. Chen, H. Gong, S. Thamphiwatana, L. Eckmann, W. Gao", "found_in_fulltext": true, - "fulltext_offset": 110030 + "fulltext_offset": 91370 }, { "block_id": "p20:13", @@ -4321,7 +4361,7 @@ "render_default": true, "snippet": "[200] Y. guang Bi, Z. Ting Lin, S. Ting Deng, Mater. Sci. Eng., C 2019, 100, 576", "found_in_fulltext": true, - "fulltext_offset": 110166 + "fulltext_offset": 91506 }, { "block_id": "p20:14", @@ -4331,7 +4371,7 @@ "render_default": true, "snippet": "[201] Z. Wang, Y. Wang, J. Yan, K. Zhang, F. Lin, L. Xiang, L. Deng, Z. Guan, W.", "found_in_fulltext": true, - "fulltext_offset": 110248 + "fulltext_offset": 91588 }, { "block_id": "p20:16", @@ -4341,7 +4381,7 @@ "render_default": true, "snippet": "Milad Vahidi is a PhD candidate in the Department of Chemical and Biochemical En", "found_in_fulltext": true, - "fulltext_offset": 106913 + "fulltext_offset": 88470 }, { "block_id": "p20:18", @@ -4351,7 +4391,7 @@ "render_default": true, "snippet": "Amin S. 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"body_flow", "reading_order", "reference_span", "same_page_boundary" ], "counts": { - "body_paragraph": 6, + "body_paragraph": 9, "reference_item": 24, - "tail_like": 10, + "tail_like": 9, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 1, - "unknown_structural": 2, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } @@ -382,7 +339,7 @@ "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -400,7 +357,7 @@ "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -418,7 +375,7 @@ "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -446,7 +403,7 @@ "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -456,17 +413,9 @@ 1, 2, 3, - 4, 5, - 6, 7, - 8, - 10, 11, - 12, - 13, - 14, - 15, 16, 20 ] diff --git a/audit/K7R8PEKW/reference_intrusion_candidates.json b/audit/K7R8PEKW/reference_intrusion_candidates.json index 048b5397..4148cce3 100644 --- a/audit/K7R8PEKW/reference_intrusion_candidates.json +++ b/audit/K7R8PEKW/reference_intrusion_candidates.json @@ -1,1894 +1,3 @@ { - "candidates": [ - { - "block_id": "p14:10", - "page": 14, - "role": "section_heading", - "zone": "reference_zone", - "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p14:11", - "page": 14, - "role": "body_paragraph", - "zone": "", - "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p14:12", - "page": 14, - "role": "noise", - "zone": "", - "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p14:13", - "page": 14, - "role": "noise", - "zone": "reference_zone", - "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p14:14", - "page": 14, - "role": "noise", - 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3, - 4, 5, - 6, - 7, - 8, 9, 10, - 11, 12, - 13, - 14, 15, 16, 17, 18, - 19, 20, 21, - 22, 23, - 24, 25 ], "reviewed_blocks": [ @@ -142,37 +131,6 @@ "p2:7", "p2:8", "p2:9", - "p3:0", - "p3:1", - "p3:2", - "p3:3", - "p3:4", - "p3:5", - "p3:6", - "p3:7", - "p3:8", - "p3:9", - "p3:10", - "p3:11", - "p3:12", - "p3:13", - "p3:14", - "p4:0", - "p4:1", - "p4:2", - "p4:3", - "p4:4", - "p4:5", - "p4:6", - "p4:7", - "p4:8", - "p4:9", - "p4:10", - "p4:11", - "p4:12", - "p4:13", - "p4:14", - "p4:15", "p5:0", "p5:1", "p5:2", @@ -190,53 +148,6 @@ "p5:14", "p5:15", "p5:16", - "p6:0", - "p6:1", - "p6:2", - "p6:3", - "p6:4", - "p6:5", - "p6:6", - "p6:7", - "p6:8", - "p6:9", - "p6:10", - "p6:11", - "p6:12", - "p7:0", - "p7:1", - "p7:2", - "p7:3", - "p7:4", - "p7:5", - "p7:6", - "p7:7", - "p7:8", - "p7:9", - "p7:10", - "p7:11", - "p7:12", - "p7:13", - "p7:14", - "p7:15", - "p7:16", - "p7:17", - "p8:0", - "p8:1", - "p8:2", - "p8:3", - "p8:4", - "p8:5", - "p8:6", - "p8:7", - "p8:8", - "p8:9", - "p8:10", - "p8:11", - "p8:12", - "p8:13", - "p8:14", - "p8:15", "p9:0", "p9:1", "p9:2", @@ -258,20 +169,6 @@ "p10:8", "p10:9", "p10:10", - "p11:0", - "p11:1", - "p11:2", - "p11:3", - "p11:4", - "p11:5", - "p11:6", - "p11:7", - "p11:8", - "p11:9", - "p11:10", - "p11:11", - "p11:12", - "p11:13", "p12:0", "p12:1", "p12:2", @@ -283,34 +180,6 @@ "p12:8", "p12:9", "p12:10", - "p13:0", - "p13:1", - "p13:2", - "p13:3", - "p13:4", - "p13:5", - "p13:6", - "p13:7", - "p13:8", - "p13:9", - "p13:10", - "p13:11", - "p13:12", - "p13:13", - "p13:14", - "p14:0", - "p14:1", - "p14:2", - "p14:3", - "p14:4", - "p14:5", - "p14:6", - "p14:7", - "p14:8", - "p14:9", - "p14:10", - "p14:11", - "p14:12", "p15:0", "p15:1", "p15:2", @@ -352,20 +221,6 @@ "p18:10", "p18:11", "p18:12", - "p19:0", - "p19:1", - "p19:2", - "p19:3", - "p19:4", - "p19:5", - "p19:6", - "p19:7", - "p19:8", - "p19:9", - "p19:10", - "p19:11", - "p19:12", - "p19:13", "p20:0", "p20:1", "p20:2", @@ -391,22 +246,6 @@ "p21:9", "p21:10", "p21:11", - "p22:0", - "p22:1", - "p22:2", - "p22:3", - "p22:4", - "p22:5", - "p22:6", - "p22:7", - "p22:8", - "p22:9", - "p22:10", - "p22:11", - "p22:12", - "p22:13", - "p22:14", - "p22:15", "p23:0", "p23:1", "p23:2", @@ -422,17 +261,6 @@ "p23:12", "p23:13", "p23:14", - "p24:0", - "p24:1", - "p24:2", - "p24:3", - "p24:4", - "p24:5", - "p24:6", - "p24:7", - "p24:8", - "p24:9", - "p24:10", "p25:0", "p25:1", "p25:2", @@ -810,18 +638,6 @@ "artifact": "reference_span_audit.json" } }, - { - "category": "frontmatter_error", - "severity": "major", - "block_ids": [], - "truth": "page 1 should have clearer frontmatter role resolution", - "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", - "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", - "evidence": { - "annotated_page": "annotated_pages/page_001.png", - "artifact": "page_risk_summary.json" - } - }, { "category": "same_page_boundary_error", "severity": "major", @@ -834,18 +650,6 @@ "artifact": "page_risk_summary.json" } }, - { - "category": "object_ownership_error", - "severity": "major", - "block_ids": [], - "truth": "figure/table ownership should map captions and assets coherently", - "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", - "root_cause_hypothesis": "caption-to-asset grouping ambiguity", - "evidence": { - "annotated_page": null, - "artifact": "figure_table_ownership_summary.json" - } - }, { "category": "render_mapping_error", "severity": "minor", @@ -864,12 +668,12 @@ "p2:0", "p2:1", "p2:2", + "p2:3", + "p2:4", + "p2:6", "p2:8", "p3:0", - "p3:1", - "p3:13", - "p4:0", - "p4:1" + "p3:1" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/KIX7SKXQ/audit_report.md b/audit/KIX7SKXQ/audit_report.md index 0fec3e9e..3f66854a 100644 --- a/audit/KIX7SKXQ/audit_report.md +++ b/audit/KIX7SKXQ/audit_report.md @@ -2,8 +2,8 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25] -- Reviewed blocks: 417 +- Reviewed pages: [1, 2, 5, 9, 10, 12, 15, 16, 17, 18, 20, 21, 23, 25] +- Reviewed blocks: 256 ## Findings @@ -27,9 +27,7 @@ - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals -- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output ## Disposition Guidance diff --git a/audit/KIX7SKXQ/audit_scope.json b/audit/KIX7SKXQ/audit_scope.json index 99c0340f..c53568c1 100644 --- a/audit/KIX7SKXQ/audit_scope.json +++ b/audit/KIX7SKXQ/audit_scope.json @@ -3,28 +3,17 @@ "selected_pages": [ 1, 2, - 3, - 4, 5, - 6, - 7, - 8, 9, 10, - 11, 12, - 13, - 14, 15, 16, 17, 18, - 19, 20, 21, - 22, 23, - 24, 25 ], "required_block_ids": [ @@ -50,81 +39,41 @@ "p1:19", "p1:20", "p2:0", - "p2:5", "p2:7", "p2:8", - "p3:7", - "p3:13", - "p4:0", - "p4:8", - "p5:10", "p5:13", "p5:14", "p5:15", - "p6:0", - "p6:7", - "p7:9", - "p7:16", - "p8:0", - "p8:8", - "p8:12", "p9:2", - "p9:4", - "p9:6", "p9:7", "p9:8", "p10:1", "p10:3", "p10:4", - "p10:8", - "p11:6", - "p11:12", "p12:0", "p12:3", "p12:4", - "p12:9", - "p13:7", - "p13:13", - "p14:0", - "p14:8", - "p15:2", "p15:4", - "p15:7", "p15:10", "p16:0", "p16:3", "p16:4", - "p16:7", - "p17:2", "p17:4", "p17:5", "p18:0", - "p18:3", "p18:4", "p18:6", "p18:8", - "p18:11", - "p19:7", - "p19:12", "p20:1", "p20:3", "p20:4", - "p20:8", "p21:2", "p21:4", - "p21:8", "p21:10", - "p22:0", - "p22:9", "p23:2", "p23:4", - "p23:10", "p23:13", - "p24:0", - "p24:7", - "p24:8", - "p25:4", - "p25:5", + "p25:6", "p25:7", "p25:9", "p25:10", @@ -278,8 +227,7 @@ "block_id": "p1:4", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -474,8 +422,7 @@ "block_id": "p1:17", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -546,21 +493,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p2:5", - "page": 2, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p2:7", "page": 2, @@ -591,81 +523,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p3:7", - "page": 3, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p3:13", - "page": 3, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:0", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:8", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p5:10", - "page": 5, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:13", "page": 5, @@ -711,111 +568,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p6:0", - "page": 6, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p6:7", - "page": 6, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:9", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:16", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:0", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:8", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:12", - "page": 8, - "required_reason": [ - "same_page_boundary" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p9:2", "page": 9, @@ -831,36 +583,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p9:4", - "page": 9, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p9:6", - "page": 9, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p9:7", "page": 9, @@ -936,51 +658,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p10:8", - "page": 10, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:6", - "page": 11, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:12", - "page": 11, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p12:0", "page": 12, @@ -1026,96 +703,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p12:9", - "page": 12, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p13:7", - "page": 13, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p13:13", - "page": 13, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p14:0", - "page": 14, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p14:8", - "page": 14, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p15:2", - "page": 15, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p15:4", "page": 15, @@ -1131,21 +718,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p15:7", - "page": 15, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p15:10", "page": 15, @@ -1206,36 +778,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p16:7", - "page": 16, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p17:2", - "page": 17, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p17:4", "page": 17, @@ -1281,21 +823,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p18:3", - "page": 18, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p18:4", "page": 18, @@ -1341,51 +868,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p18:11", - "page": 18, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p19:7", - "page": 19, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p19:12", - "page": 19, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p20:1", "page": 20, @@ -1431,21 +913,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p20:8", - "page": 20, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p21:2", "page": 21, @@ -1476,21 +943,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p21:8", - "page": 21, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p21:10", "page": 21, @@ -1506,36 +958,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p22:0", - "page": 22, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p22:9", - "page": 22, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p23:2", "page": 23, @@ -1566,21 +988,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p23:10", - "page": 23, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p23:13", "page": 23, @@ -1597,67 +1004,7 @@ ] }, { - "block_id": "p24:0", - "page": 24, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p24:7", - "page": 24, - "required_reason": [ - "same_page_boundary" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p24:8", - "page": 24, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:4", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:5", + "block_id": "p25:6", "page": 25, "required_reason": [ "backmatter" @@ -2986,122 +2333,67 @@ { "page": 2, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 3, - "must_review_page": true, - "required_block_count": 2 - }, - { - "page": 4, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 3 }, { "page": 5, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 6, - "must_review_page": true, - "required_block_count": 2 - }, - { - "page": 7, - "must_review_page": true, - "required_block_count": 2 - }, - { - "page": 8, - "must_review_page": true, "required_block_count": 3 }, { "page": 9, "must_review_page": true, - "required_block_count": 5 + "required_block_count": 3 }, { "page": 10, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 11, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 3 }, { "page": 12, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 13, - "must_review_page": true, - "required_block_count": 2 - }, - { - "page": 14, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 3 }, { "page": 15, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 2 }, { "page": 16, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 3 }, { "page": 17, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 2 }, { "page": 18, "must_review_page": true, - "required_block_count": 6 - }, - { - "page": 19, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 4 }, { "page": 20, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 3 }, { "page": 21, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 22, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 3 }, { "page": 23, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 24, - "must_review_page": true, "required_block_count": 3 }, { "page": 25, "must_review_page": true, - "required_block_count": 89 + "required_block_count": 88 } ] } \ No newline at end of file diff --git a/audit/KIX7SKXQ/block_coverage_summary.json b/audit/KIX7SKXQ/block_coverage_summary.json index 54f6ccc9..f1e4a5a7 100644 --- a/audit/KIX7SKXQ/block_coverage_summary.json +++ b/audit/KIX7SKXQ/block_coverage_summary.json @@ -144,7 +144,7 @@ "block_id": "p1:4", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", "bbox": [ 454.0, @@ -404,8 +404,8 @@ "block_id": "p1:17", "page": 1, "raw_label": "text", - "role": "unknown_structural", - "zone": "frontmatter_main_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 626.0, 1344.0, @@ -584,7 +584,7 @@ "block_id": "p2:5", "page": 2, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -824,7 +824,7 @@ "block_id": "p3:7", "page": 3, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -1144,7 +1144,7 @@ "block_id": "p4:8", "page": 4, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -1504,7 +1504,7 @@ "block_id": "p5:10", "page": 5, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -1784,7 +1784,7 @@ "block_id": "p6:7", "page": 6, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 617.0, @@ -2084,7 +2084,7 @@ "block_id": "p7:9", "page": 7, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 627.0, @@ -2424,7 +2424,7 @@ "block_id": "p8:8", "page": 8, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -2664,7 +2664,7 @@ "block_id": "p9:4", "page": 9, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -2704,7 +2704,7 @@ "block_id": "p9:6", "page": 9, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 80.0, @@ -2724,7 +2724,7 @@ "block_id": "p9:7", "page": 9, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 81.0, @@ -2944,7 +2944,7 @@ "block_id": "p10:8", "page": 10, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -3124,7 +3124,7 @@ "block_id": "p11:6", "page": 11, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -3464,7 +3464,7 @@ "block_id": "p12:9", "page": 12, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -3644,7 +3644,7 @@ "block_id": "p13:7", "page": 13, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -3964,7 +3964,7 @@ "block_id": "p14:8", "page": 14, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -4104,7 +4104,7 @@ "block_id": "p15:2", "page": 15, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 81.0, @@ -4144,7 +4144,7 @@ "block_id": "p15:4", "page": 15, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 84.0, @@ -4204,7 +4204,7 @@ "block_id": "p15:7", "page": 15, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -4444,7 +4444,7 @@ "block_id": "p16:7", "page": 16, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -4524,7 +4524,7 @@ "block_id": "p17:2", "page": 17, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 81.0, @@ -4564,7 +4564,7 @@ "block_id": "p17:4", "page": 17, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 82.0, @@ -4684,7 +4684,7 @@ "block_id": "p18:3", "page": 18, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 71.0, @@ -4704,7 +4704,7 @@ "block_id": "p18:4", "page": 18, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 75.0, @@ -4744,7 +4744,7 @@ "block_id": "p18:6", "page": 18, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 85.0, @@ -4844,7 +4844,7 @@ "block_id": "p18:11", "page": 18, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 616.0, @@ -5024,7 +5024,7 @@ "block_id": "p19:7", "page": 19, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -5224,7 +5224,7 @@ "block_id": "p20:3", "page": 20, "raw_label": "image", - "role": "figure_asset", + "role": "media_asset", "zone": "body_zone", "bbox": [ 70.0, @@ -5324,7 +5324,7 @@ "block_id": "p20:8", "page": 20, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 615.0, @@ -5464,7 +5464,7 @@ "block_id": "p21:2", "page": 21, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 101.0, @@ -5584,7 +5584,7 @@ "block_id": "p21:8", "page": 21, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 627.0, @@ -5844,7 +5844,7 @@ "block_id": "p22:9", "page": 22, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 614.0, @@ -6024,7 +6024,7 @@ "block_id": "p23:2", "page": 23, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 96.0, @@ -6184,7 +6184,7 @@ "block_id": "p23:10", "page": 23, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 626.0, @@ -6444,7 +6444,7 @@ "block_id": "p24:8", "page": 24, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 614.0, @@ -6584,7 +6584,7 @@ "block_id": "p25:4", "page": 25, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 81.0, @@ -6604,7 +6604,7 @@ "block_id": "p25:5", "page": 25, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 104.0, @@ -6624,7 +6624,7 @@ "block_id": "p25:6", "page": 25, "raw_label": "paragraph_title", - "role": "section_heading", + "role": "backmatter_heading", "zone": "body_zone", "bbox": [ 80.0, @@ -6664,7 +6664,7 @@ "block_id": "p25:8", "page": 25, "raw_label": "paragraph_title", - "role": "section_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "bbox": [ 81.0, @@ -6985,7 +6985,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 638.0, 124.0, @@ -7005,7 +7005,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 143.0, @@ -7025,7 +7025,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 162.0, @@ -7045,7 +7045,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 198.0, @@ -7065,7 +7065,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 217.0, @@ -7085,7 +7085,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 238.0, @@ -7105,7 +7105,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 257.0, @@ -7125,7 +7125,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 276.0, @@ -7145,7 +7145,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 294.0, @@ -7165,7 +7165,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 313.0, @@ -7185,7 +7185,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 352.0, @@ -7205,7 +7205,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 371.0, @@ -7225,7 +7225,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 388.0, @@ -7245,7 +7245,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 641.0, 407.0, @@ -7265,7 +7265,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 427.0, @@ -7285,7 +7285,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 445.0, @@ -7305,7 +7305,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 464.0, @@ -7325,7 +7325,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 484.0, @@ -7345,7 +7345,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 502.0, @@ -7365,7 +7365,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 522.0, @@ -7385,7 +7385,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 539.0, @@ -7405,7 +7405,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 560.0, @@ -7425,7 +7425,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 579.0, @@ -7445,7 +7445,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 597.0, @@ -7465,7 +7465,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 636.0, @@ -7485,7 +7485,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 642.0, 654.0, @@ -7505,7 +7505,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 672.0, @@ -7525,7 +7525,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 691.0, @@ -7545,7 +7545,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 712.0, @@ -7565,7 +7565,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 730.0, @@ -7585,7 +7585,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 749.0, @@ -7605,7 +7605,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 767.0, @@ -7625,7 +7625,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 788.0, @@ -7645,7 +7645,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 804.0, @@ -7665,7 +7665,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 825.0, @@ -7685,7 +7685,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 847.0, @@ -7705,7 +7705,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 863.0, @@ -7725,7 +7725,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 881.0, @@ -7745,7 +7745,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 900.0, @@ -7765,7 +7765,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 921.0, @@ -7785,7 +7785,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 938.0, @@ -7805,7 +7805,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 956.0, @@ -7825,7 +7825,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 976.0, @@ -7845,7 +7845,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 997.0, @@ -7865,7 +7865,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 1015.0, @@ -7885,7 +7885,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 1033.0, @@ -7905,7 +7905,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 1054.0, @@ -7925,7 +7925,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 1071.0, @@ -7945,7 +7945,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 641.0, 1088.0, @@ -7965,7 +7965,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 641.0, 1107.0, @@ -7985,7 +7985,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 1128.0, @@ -8005,7 +8005,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 640.0, 1146.0, @@ -8025,7 +8025,7 @@ "page": 25, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 639.0, 1185.0, diff --git a/audit/KIX7SKXQ/block_trace.csv b/audit/KIX7SKXQ/block_trace.csv index 85cefb4d..5cf40fc7 100644 --- a/audit/KIX7SKXQ/block_trace.csv +++ b/audit/KIX7SKXQ/block_trace.csv @@ -3,8 +3,8 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,1,header_image,,"[83.0, 118.0, 171.0, 216.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False 1,2,header,RESEARCH,"[1079.0, 60.0, 1160.0, 77.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False 1,3,header_image,,"[1098.0, 120.0, 1154.0, 177.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False -1,4,text,HIGHLIGHTED PAPER,"[454.0, 182.0, 800.0, 218.0]",unknown_structural,0.6,"[""page-1 initial-lastname author byline: HIGHLIGHTED PAPER""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True -1,5,doc_title,Electrical stimulation system based on electroactive biomaterials for bone tissue engineering,"[76.0, 315.0, 1135.0, 496.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Electrical stimulation system based on electroactive biomate""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,text,HIGHLIGHTED PAPER,"[454.0, 182.0, 800.0, 218.0]",authors,0.6,"[""page-1 initial-lastname author byline: HIGHLIGHTED PAPER""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,5,doc_title,Electrical stimulation system based on electroactive biomaterials for bone tissue engineering,"[76.0, 315.0, 1135.0, 496.0]",paper_title,0.8,"[""page-1 zone title_zone: Electrical stimulation system based on electroactive biomate""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True 1,6,text,"Xiaodi Zhang $ ^{a,b} $, Tong Wang $ ^{a} $, Zhongyang Zhang $ ^{b} $, Haiqing Liu $ ^{d} $, Longfei Li $ ^{a} $, Aochen Wang $ ^{e} $, Jiang Ouyang $ ^{b} $, Tian Xie $ ^{f} $, Liqun Zhang $ ^{a,c} $","[81.0, 515.0, 1153.0, 584.0]",authors,0.8,"[""page-1 zone author_zone: Xiaodi Zhang $ ^{a,b} $, Tong Wang $ ^{a} $, Zhongyang Zhang""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,7,text," $ ^{a} $ Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China","[79.0, 614.0, 848.0, 636.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $ Beijing Laboratory of Biomedical Materials, Beijing""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True 1,8,text," $ ^{b} $ Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States @@ -17,7 +17,10 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,14,text,Keywords: Bone tissue engineering; Electroactive materials; Piezoelectric materials; Conductive polymers; Carbon-based materials; Triboelectric nanogenerator; Ion channels,"[79.0, 1275.0, 1155.0, 1321.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: Bone tissue engineering; Electroactive materials; ""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False 1,15,paragraph_title,Introduction,"[80.0, 1346.0, 209.0, 1368.0]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True 1,16,text,"Bone is a complex calcified tissue with a highly hierarchical structure that plays a pivotal role in daily physiological activities, such as supporting the body, protecting internal organs, and mainta","[78.0, 1372.0, 605.0, 1445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -1,17,text,,"[626.0, 1344.0, 1156.0, 1488.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,empty,False,True +1,17,text,"maintaining hematopoiesis and mineral homeostasis [1,275]. +The bone naturally undergoes continuous self-renewal and heal- +ing by dynamically balancing osteoblastic bone-formation and +osteoclastic bone","[626.0, 1344.0, 1156.0, 1488.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,18,footnote,"* Corresponding authors. E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard.edu).","[87.0, 1471.0, 588.0, 1509.0]",footnote,0.7,"[""footnote label: * Corresponding authors.\nE-mail addresses: Xue, J. (jiajaxue""]",footnote,0.7,body_zone,body_like,none,True,True 1,19,footer,1369-7021/© 2023 Elsevier Ltd. All rights reserved. https://doi.org/10.1016/j.mattod.2023.06.011,"[81.0, 1529.0, 614.0, 1548.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -27,7 +30,8 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 2,2,header,Materials Today • Volume 68 • September 2023,"[802.0, 61.0, 1142.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False 2,3,text,"after the remodeling. However, clinical intervention will be necessary when the bone defect is over a critical size or in cases of poor osteogenesis conditions due to some diseases such as osteoporosi","[66.0, 122.0, 595.0, 433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,4,text,"It is well known that the endogenous electric field (EnEF) plays a guiding role in embryogenesis, physiological activities, wound healing, tissue remodeling, and other biological processes, which are ","[67.0, 433.0, 596.0, 820.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,5,text,,"[615.0, 123.0, 1143.0, 169.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,5,text,"structure [14], which can convert the compressive load generated +by physiological activities into piezoelectric potential.","[615.0, 123.0, 1143.0, 169.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,6,text,"In this context, electroactive biomaterials (EABMs) have emerged. EABMs are a new generation of ""smart"" biomaterials capable of applying electrical stimulation (ES) directly to target cells or tissues","[613.0, 170.0, 1146.0, 819.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,7,image,,"[87.0, 888.0, 1121.0, 1443.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 2,8,figure_title,Schematic diagram of the piezoelectric properties of bone and the response of cells to electrical signals.,"[69.0, 1484.0, 803.0, 1509.0]",figure_caption_candidate,0.85,"[""figure_title label: Schematic diagram of the piezoelectric properties of bone an""]",figure_caption,0.85,body_zone,legend_like,none,False,False @@ -39,7 +43,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 3,4,paragraph_title,Endogenous and the interaction of electric signals with cells,"[78.0, 714.0, 577.0, 764.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Endogenous and the interaction of electric signals with cell""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 3,5,text,"Ever since Luigi Galvani's groundbreaking observation of muscle contractions through ES of the frog's sciatic nerve [43], a strong connection has been established between biology and electricity. This","[78.0, 768.0, 605.0, 1127.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,6,text,"In recent years, there has been increasing attention towards harnessing EnEF or simulating them by applying exogenous electric field (ExEF) for therapeutic applications. Unlike the EnEF that naturally","[78.0, 1128.0, 606.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,7,text,,"[626.0, 123.0, 1156.0, 266.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +3,7,text,"Studying and understanding EnEF in living organisms will +help us accelerate tissue regeneration by applying exogenous +ES. Therefore, this chapter aims to explore EnEF in bone tissue +and show how elect","[626.0, 123.0, 1156.0, 266.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,8,paragraph_title,Piezoelectricity in bone tissue,"[629.0, 289.0, 883.0, 312.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Piezoelectricity in bone tissue""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 3,9,text,One of the most interesting types of EnEF is bio-piezoelectricity [47]. Piezoelectricity refers to the ability of a material to convert mechanical stimuli into electrical signals. Since the phenomenon,"[627.0, 315.0, 1155.0, 649.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,10,text,"The piezoelectricity of bone tissue is attributed to collagen molecules with non-centrosymmetric structures, which are the most common naturally-derived piezoelectric biomaterials in the human body (F","[626.0, 651.0, 1156.0, 1344.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -55,7 +62,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 4,5,text,"A sufficient number of cells grown on bio-scaffolds is a prerequisite for achieving a satisfied healing effect in tissue engineering. The influence of ES on cell proliferation can vary, depending on t","[65.0, 316.0, 596.0, 1151.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,6,paragraph_title,Cell alignment,"[69.0, 1177.0, 183.0, 1198.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell alignment""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True 4,7,text,"Cells in natural tissue are mostly arranged in an orderly manner. Therefore, replicating the ordered arrangement of cells on the scaffold can benefit its fusion with native tissues [66]. It has been c","[66.0, 1198.0, 595.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,8,text,,"[615.0, 123.0, 1145.0, 435.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,8,text,"triphosphate (ATP) and free calcium will further increase the +contractility of the cytoskeleton, leading to cell detachment from +its focal adhesions (FA). The cytoskeletal contraction squeezes +the cyt","[615.0, 123.0, 1145.0, 435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,9,paragraph_title,Cell migration,"[618.0, 458.0, 729.0, 479.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell migration""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True 4,10,text,"Inducing the migration of endogenous cells to the wound site is conducive to the recruitment of cells during healing. This process is generally driven by the EnEF generated at the wound site, while ap","[614.0, 482.0, 1145.0, 912.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,11,paragraph_title,Cell adhesion,"[618.0, 936.0, 724.0, 957.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell adhesion""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True @@ -73,7 +83,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 5,7,text,"Conductive biomaterials can possess versatile properties in additional to excellent electrical conductivity, which endows them with potential values in BTE. Whereas, they also exhibit shortages to som","[78.0, 467.0, 606.0, 756.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,8,paragraph_title,Carbon-based nanomaterials,"[80.0, 776.0, 295.0, 797.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Carbon-based nanomaterials""]",subsection_heading,0.6,body_zone,body_like,none,True,True 5,9,text,"Carbon nanotubes. Carbon nanotubes, both single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), have cylindrical carbon structures that endow them with large surface areas","[77.0, 799.0, 606.0, 1039.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -5,10,text,,"[626.0, 124.0, 1157.0, 360.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +5,10,text,"properties (Young’s modulus up to 1 TPa and tensile strength +of 63 GPa). Moreover, the multi-layered structure of MWCNTs +can preserve their high conductivity even with several surface +modifications, wh","[626.0, 124.0, 1157.0, 360.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,11,text,"Despite the as-explored promising applications in biomedical engineering, the safety of CNTs has been a constant source of vigilance. In a recent report, CNTs were added to the SIN ('Substitute It Now","[626.0, 362.0, 1156.0, 671.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,12,text,"Graphene and its derivatives. Graphene has attracted enormous interest since it was obtained through mechanical exfoliation from graphite in 2004 [91]. Similar to SWCNTs, graphene, with sp² hybridized","[626.0, 674.0, 1156.0, 1032.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,13,image,,"[93.0, 1072.0, 1136.0, 1454.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True @@ -87,7 +100,8 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 6,4,text,"While graphene is excreted by the kidney through blood circulation $ [108,109] $, it can also be absorbed by other organs, such as the brain, heart, liver, lung, etc. $ [108,110] $. Cytotoxicity of ","[67.0, 601.0, 594.0, 889.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,5,paragraph_title,Conducting polymers,"[69.0, 938.0, 229.0, 958.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conducting polymers""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True 6,6,text,Conducting polymers (CPs) are defined as a class of organic materials that not only have unique electrical and optical properties similar to metals and semiconductors but also exhibit attractive prope,"[67.0, 960.0, 595.0, 1511.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -6,7,text,,"[617.0, 123.0, 1143.0, 169.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +6,7,text,"delivery devices, as well as constructing electroactive scaffolds +for tissue engineering.","[617.0, 123.0, 1143.0, 169.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,8,text,The charge-conducting ability of CPs is attributed to electrons jumping within and between the polymer chains. Conjugated systems in CPs are composed of $ \pi $ molecular orbitals formed by overlappi,"[615.0, 171.0, 1145.0, 625.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,9,text,"Polypyrrole (PPy). PPy and its derivatives, one class of the most widely studied CPs, have demonstrated potential for biomedical applications especially in tissue engineering, electro-responsive drug ","[615.0, 626.0, 1145.0, 912.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,10,text,"Polyaniline (PANi). Polyaniline, mainly existing in three forms including fully oxidized (pernigraniline base), half oxidized (emeraldine base) and completely reduced (leucoemeraldine), has also been ","[615.0, 913.0, 1145.0, 1150.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -102,7 +116,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 7,6,text,"Silver nanomaterials (AgNMs). Compared with AuNMs, AgNMs have better electrical and thermal conductivity properties. In addition, AgNMs have unique antibacterial properties, exhibiting strong antibact","[78.0, 1199.0, 605.0, 1414.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,7,paragraph_title,Mxene,"[79.0, 1441.0, 138.0, 1460.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Mxene""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True 7,8,text,"In recent years, MXene has emerged as a promising two-dimensional nanomaterial, displaying exceptional electrical conductivity, high volume capacitance, excellent mechanical properties, and optical pr","[78.0, 1463.0, 605.0, 1509.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -7,9,text,,"[627.0, 124.0, 1156.0, 456.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +7,9,text,"ductivity, high volume capacitance, excellent mechanical prop- +erties, and optical properties. The presence of surface +termination groups facilitates its dispersion in aqueous phases +and organic solve","[627.0, 124.0, 1156.0, 456.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,10,text,"The outstanding conductive properties of MXene can be attributed to several factors. Firstly, MXene encompasses transition metals, which inherently possess metallic properties, thus endowing them with","[626.0, 458.0, 1156.0, 890.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,11,paragraph_title,Piezoelectric materials,"[629.0, 913.0, 823.0, 935.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Piezoelectric materials""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 7,12,text,"Piezoelectric material is a kind of material that can achieve electromechanical conversion. As a result, piezoelectric materials can regenerate local electrical signals in situ without the need for el","[626.0, 938.0, 1156.0, 1248.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -119,7 +136,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 8,5,paragraph_title,Piezoelectric polymers,"[69.0, 652.0, 232.0, 672.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Piezoelectric polymers""]",subsection_heading,0.6,body_zone,body_like,none,True,True 8,6,text,"Although the piezoelectric properties of piezoelectric polymers are not as good as piezoceramics, they have better mechanical properties and biocompatibility, and can be processed in a variety of ways","[67.0, 673.0, 594.0, 1008.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_side_zone,body_like,none,True,True 8,7,text,"PVDF and its copolymers are one of the most investigated bio-piezoelectric polymers. Although PVDF is composed of $ -CH_{2}-CF_{2}-monomer $, different arrangements of hydrogen and fluorine atoms lea","[67.0, 1009.0, 594.0, 1509.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,8,text,,"[615.0, 123.0, 1144.0, 383.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,8,text,"PLLA is another commonly used piezoelectric polymer, which +has better biocompatibility and biodegradability than PVDF. Its +piezoelectricity is similar to that of human bones, and its shear +piezoelectr","[615.0, 123.0, 1144.0, 383.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,9,text,"Although piezoelectric polymers have better processability and flexibility, their piezoelectric coefficients are relatively lower compared to that of piezoceramics. Therefore, piezoelectric composite ","[616.0, 385.0, 1145.0, 530.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,10,paragraph_title,Application in bone healing,"[618.0, 566.0, 898.0, 591.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Application in bone healing""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 8,11,text,"The process of bone healing is usually divided into the following four consecutive stages: inflammation, fibrogenic callus formation, bone formation, and bone reconstruction/remodeling [1]. A variety ","[615.0, 594.0, 1145.0, 784.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -131,10 +151,13 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 9,1,header,RESEARCH,"[1071.0, 61.0, 1154.0, 80.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 9,2,text,"on the application of electroactive scaffolds to promote osteogenesis only rely on presence of EnEF and potential difference in situ, without external ES. The references of electrical properties of el","[77.0, 123.0, 606.0, 290.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,3,text,"Conductive polymers, as emerging conductive materials, are attempted to be used as conductive scaffolds for bone tissue engineering. The electrical conductivity of the fibrous mesh reached $ 0.094 \p","[77.0, 290.0, 607.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -9,4,text,,"[626.0, 123.0, 1156.0, 457.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +9,4,text,"was obtained. Under physiologically relevant low frequencies, +the impedance of GelMA-PANi was significantly lower than that +of pure GelMA, and based on this conductive hydrogel, a +microstructure can be","[626.0, 123.0, 1156.0, 457.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,5,text,"Carbon-based nanomaterials have also been shown to interact with osteoblasts to induce bone calcification. A composite material consisting of CNTs, HAp, and bioactive glass nanoparticles (BAG NPs) was","[624.0, 458.0, 1157.0, 915.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -9,6,figure_title,TABLE 1,"[80.0, 955.0, 145.0, 975.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 1""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -9,7,table,"
Electrical properties of electroactive scaffolds and their effects on bone healing in the absence of exogenous stimuli.
Electroactive materialsElec","[81.0, 983.0, 1153.0, 1507.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +9,6,figure_title,TABLE 1,"[80.0, 955.0, 145.0, 975.0]",table_caption,0.9,"[""table prefix matched: TABLE 1""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,7,table,"
Electrical properties of electroactive scaffolds and their effects on bone healing in the absence of exogenous stimuli.
Electroactive materialsElec","[81.0, 983.0, 1153.0, 1507.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 9,8,aside_text,RESEARCH: Review,"[1182.0, 341.0, 1199.0, 481.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True 9,9,number,185,"[1122.0, 1536.0, 1154.0, 1554.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 10,0,header,RESEARCH,"[72.0, 62.0, 153.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -145,7 +168,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 10,5,text,membrane with a core–shell structure demonstrates enhanced adhesion properties for hMSCs [163].,"[68.0, 1169.0, 593.0, 1215.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,6,text,"As bone implants, redox reactions on carbon steel surfaces may cause adverse effects such as corrosion, release of metal ions, biocompatibility issues, and impaired mechanical properties. As shown in ","[67.0, 1217.0, 594.0, 1454.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,7,text,"As natural bones have piezoelectricity, piezoelectric materials that can respond to physiological loads and generate electric fields inside bone tissue, making them theoretically more suitable for bon","[68.0, 1456.0, 595.0, 1503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,8,text,,"[615.0, 1169.0, 1145.0, 1287.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,8,text,"fields inside bone tissue, making them theoretically more suit- +able for bone regeneration. Generally, the bone compression area +generates an endogenous negative potential, while the negative +potential","[615.0, 1169.0, 1145.0, 1287.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,9,text,"Barium titanate (BT) with a high piezoelectrical coefficient is the most popular piezoelectric ceramic, which is usually used for preparing piezoelectric composites. For example, polydopamine (PDA, Do","[615.0, 1288.0, 1146.0, 1504.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,10,number,186,"[72.0, 1536.0, 103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 11,0,header,Materials Today • Volume 68 • September 2023,"[81.0, 61.0, 421.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False @@ -154,7 +180,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 11,3,text,"ZnO is also a common EABM used for bone repair. Like most nanoparticles, the biotoxicity of ZnO is also dose-dependent, which led to reduced cell viability of MSCs when its concentration reaches 60 µg","[78.0, 578.0, 605.0, 816.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,4,text,"Besides, other piezoceramics have been applied in bone repair as well. For instance, a negative charge on the surface of lithium sodium potassium niobate porous scaffold can promote FA and proliferati","[79.0, 819.0, 605.0, 1198.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,5,text,"Electrospinning is a well-known and attractive nanofabrication technique, which has been widely used for fabricating nanostructures with piezoelectric polymers. Compared with the film prepared by spin","[78.0, 1200.0, 606.0, 1512.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,6,text,,"[626.0, 123.0, 1155.0, 433.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +11,6,text,"closer to the cell membrane potential (MG63: 60 mV), pro- +moted the formation and mineralization of collagen [174]. +Biodegradable PLLA scaffold can also be used to enhance bone +regeneration [175]. Com","[626.0, 123.0, 1155.0, 433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,7,text,"In fact, one thing that needs to be faced squarely is that piezoelectric polymers usually do not have supporting capabilities. Most recent studies are limited to in vitro experiments. Even if in vivo ","[627.0, 435.0, 1155.0, 624.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,8,paragraph_title,Chondrogenesis,"[630.0, 648.0, 772.0, 671.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Chondrogenesis""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 11,9,text,"Except for lamellar bones such as the skull, the development and repair of other long bones in the human body need to undergo endochondral ossification. The chondrocytes differentiated from stem cells","[626.0, 674.0, 1156.0, 1055.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -171,7 +200,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 12,6,text,It can be speculated from the very limited available works that the electrical signals required for chondrogenic differentiation could be weaker than that for osteogenic differentiation. Considering t,"[66.0, 1172.0, 594.0, 1339.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,7,paragraph_title,Vascularization,"[69.0, 1367.0, 204.0, 1388.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Vascularization""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 12,8,text,"One of the crucial issues for fracture healing is angiogenesis, especially in open fractures, poor blood supply can lead to a higher risk of fracture nonunion. New blood vessels can bring nutrients, m","[67.0, 1390.0, 594.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -12,9,text,,"[615.0, 1027.0, 1146.0, 1507.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +12,9,text,"tissue regeneration [190,191]. It is worth noting that blood ves- +sels also retain piezoelectric properties, Fukada and Hara found +piezoelectricity in aorta and vena in 1969 [192], which are +mainly at","[615.0, 1027.0, 1146.0, 1507.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,10,number,188,"[72.0, 1536.0, 103.0, 1554.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 13,0,header,Materials Today • Volume 68 • September 2023,"[81.0, 61.0, 421.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 13,1,header,RESEARCH,"[1071.0, 61.0, 1154.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -180,7 +212,10 @@ E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard 13,4,paragraph_title,Anti-bacteria,"[79.0, 769.0, 197.0, 790.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Anti-bacteria""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 13,5,text,"For open fractures, wound infection will not only hinder the healing progress, leading to bone nonunion, but also increase the risks of subsequent deep infections, such as osteomyelitis. Therefore, th","[78.0, 793.0, 606.0, 1198.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,6,text,Doping the piezoelectric phase Na₀.₅K₀.₅NbO₃ in 1392 BAG could reduce the population of bacteria while promoting the viability of MG-63 cells. Polarized composite material with static surface electric,"[77.0, 1201.0, 606.0, 1511.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -13,7,text,,"[626.0, 123.0, 1156.0, 553.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +13,7,text,"on positively polarized HAp-BT composites [208]. Another study +working on ZnO/PVDF composite nanofiber scaffold also proved +that piezoelectric excitation in the scaffold could inhibit the +growth of bac","[626.0, 123.0, 1156.0, 553.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,8,paragraph_title,Drug delivery,"[629.0, 576.0, 752.0, 599.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Drug delivery""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 13,9,text,"The principle for utilizing CP for electro-responsive drug delivery is based on the switch of polymers between oxidized and reduced states, which enables the capture and release of charged molecules t","[627.0, 601.0, 1156.0, 816.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,10,text,"For healing bone defects caused by major amputation or disease, the controlled release of bioactive effectors at the bone defect conduces to promote osteogenesis. As shown in Fig. 4d, the electroactiv","[626.0, 818.0, 1156.0, 1102.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -197,19 +232,25 @@ Exogenous electrical stimulation","[68.0, 385.0, 555.0, 432.0]",subsection_headi 14,5,text,"Exogenous ES equipment has been used clinically to treat fracture healing, nonunion, and osteoporosis and enhance spinal fusion. Current clinical-use ES devices are usually divided into two modes: inv","[67.0, 432.0, 594.0, 1296.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,6,text,"In most in vitro studies, invasive ES is performed by directly immersing electrodes in the culture medium. According to different commercial electric stimulators, most of the applied electrical signal","[67.0, 1296.0, 594.0, 1461.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,7,text,"In the aforementioned work of treating osteoporotic fractures, the electrodes were tightly integrated with conductive rGO/zinc silicate/calcium silicate (rGO/ZS/CS) biocomposites scaffold, and Keithle","[68.0, 1463.0, 594.0, 1509.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -14,8,text,,"[615.0, 121.0, 1145.0, 601.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +14,8,text,"silicate/calcium silicate (rGO/ZS/CS) biocomposites scaffold, and +Keithley (2400) was used as a power supply to provide bMSCs +with a direct current of 3 lA for 1 h per day (Fig. 5a) [198]. Keith- +ley ","[615.0, 121.0, 1145.0, 601.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,9,text,The application of pulsed electrical signals can solve the hyperthermia side-effect caused by DC [226]. BMSCs cultured on conductive poly[(alanine ethyl ester)-(glycine ethyl ester)] phosphazene/CNT (,"[614.0, 602.0, 1146.0, 1248.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,10,text,"There are also some works that provide ES parameters based on AC electric field density. For example, a carbon electrode was placed in a culture plate, and MC3T3 cells on CNT-PEG-acrylate and black ph","[614.0, 1247.0, 1145.0, 1460.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,11,text,Salt bridge is another invasive ES method. The salt bridge can separate cells from metallic electrodes to avoid excessive electro-,"[617.0, 1463.0, 1145.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,12,number,190,"[72.0, 1536.0, 103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 15,0,header,Materials Today • Volume 68 • September 2023,"[81.0, 61.0, 422.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 15,1,header,RESEARCH,"[1071.0, 61.0, 1154.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -15,2,figure_title,TABLE 2,"[81.0, 123.0, 144.0, 143.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 2""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +15,2,figure_title,TABLE 2,"[81.0, 123.0, 144.0, 143.0]",table_caption,0.9,"[""table prefix matched: TABLE 2""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 15,3,figure_title,Effects of electroactive scaffolds on bone healing in the presence of exogenous electrical stimulation and electrical stimulation parameters.,"[82.0, 150.0, 1093.0, 172.0]",figure_caption,0.85,"[""figure_title label: Effects of electroactive scaffolds on bone healing in the pr""]",figure_caption,0.85,body_zone,legend_like,none,True,True -15,4,table,"
Application modeElectroactive materialsES parametersEffectRefs.
DC ESDiamond-Graphite Nanoplatelet3 $","[84.0, 159.0, 1142.0, 829.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +15,4,table,"
Application modeElectroactive materialsES parametersEffectRefs.
DC ESDiamond-Graphite Nanoplatelet3 $","[84.0, 159.0, 1142.0, 829.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 15,5,text,"chemical reaction products. As shown in Fig. 5b, bio-agar salt bridges with a T-shaped structure were used to replace metallic electrodes. To ensure the uniform distribution of the electric field on e","[78.0, 871.0, 606.0, 1180.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 15,6,text,"There are also several works that use non-invasive ES. In a study investigating how ES affects bone formation on 3D PCL/CNT and PCL/β-tricalcium phosphate (TCP) composite materials, the electrode cult","[77.0, 1181.0, 607.0, 1492.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -15,7,text,,"[626.0, 870.0, 1157.0, 1111.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +15,7,text,"tive effects of external magnetic forces on osteogenesis, it has +also been confirmed that IC stimulation led to an additional pro- +motion of osteogenesis (Fig. 5d) [235]. Another way to achieve +non-inv","[626.0, 870.0, 1157.0, 1111.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 15,8,paragraph_title,"Self-powdered electrical signal source Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Self-powdered electrical signal source\nPiezoelectric nanogen""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 15,9,text,"Piezoelectric materials can regulate cell behavior by providing different forms of electrical signals. Piezoelectric materials with surface charges/potential after polarization were firstly studied, m","[627.0, 1200.0, 1157.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -222,27 +263,33 @@ Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection 16,4,figure_title,"A) bone regeneration activity is enhanced when 3 µa direct current stimulates mbmscs cultured on the surface of rgo/zs/cs. Reproduced with permission[198]. Copyright 2017, American Chemical Society. b","[68.0, 1012.0, 1145.0, 1114.0]",figure_caption_candidate,0.85,"[""figure_title label: A) bone regeneration activity is enhanced when 3 \u00b5a direct c""]",figure_caption,0.85,body_zone,support_like,none,False,False 16,5,text,electrical stimulation generated by PENG and demonstrated their role in bone healing in Table 3.,"[68.0, 1167.0, 593.0, 1212.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 16,6,text,Some studies suggest that negatively charged surfaces can stimulate cell adhesion and growth. HAp/BT piezocomposites with negative charges on the surface after electric polarization could induce the a,"[67.0, 1215.0, 594.0, 1502.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -16,7,text,,"[615.0, 1166.0, 1146.0, 1503.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +16,7,text,"some works exploring the effect of quantified surface potential +on osteogenic differentiation. By controlling the spontaneous +polarization direction and magnitude of GaN, two films of N- +GaN/AlGaN with ","[615.0, 1166.0, 1146.0, 1503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 16,8,number,192,"[71.0, 1536.0, 103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 17,0,header,Materials Today • Volume 68 • September 2023,"[81.0, 61.0, 422.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 17,1,header,RESEARCH,"[1071.0, 61.0, 1154.0, 80.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -17,2,figure_title,TABLE 3,"[81.0, 123.0, 144.0, 142.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 3""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +17,2,figure_title,TABLE 3,"[81.0, 123.0, 144.0, 142.0]",table_caption,0.9,"[""table prefix matched: TABLE 3""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 17,3,figure_title,Effects of in situ electrical stimulation generated by piezoelectric materials on bone healing.,"[82.0, 150.0, 754.0, 172.0]",figure_caption,0.85,"[""figure_title label: Effects of in situ electrical stimulation generated by piezo""]",figure_caption,0.85,body_zone,legend_like,none,True,True -17,4,table,"
Effects of in situ electrical stimulation generated by piezoelectric materials on bone healing.
Trigger modeElectroactive materialsPiezoel","[82.0, 155.0, 1140.0, 1493.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +17,4,table,"
Effects of in situ electrical stimulation generated by piezoelectric materials on bone healing.
Trigger modeElectroactive materialsPiezoel","[82.0, 155.0, 1140.0, 1493.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 17,5,aside_text,RESEARCH: Review,"[1182.0, 341.0, 1199.0, 481.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True 17,6,number,193,"[1123.0, 1537.0, 1153.0, 1554.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 18,0,aside_text,RESEARCH: Review,"[25.0, 341.0, 42.0, 482.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True 18,1,header,RESEARCH,"[72.0, 61.0, 154.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 18,2,header,Materials Today • Volume 68 • September 2023,"[803.0, 61.0, 1142.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -18,3,figure_title,TABLE 3 (CONTINUED),"[71.0, 126.0, 224.0, 145.0]",table_caption_candidate,0.9,"[""table prefix matched: TABLE 3 (CONTINUED)""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -18,4,table,"
Trigger modeElectroactive materialsPiezoelectric effectEffectHighlightsRef.
MagnetostrictionWhitlockit","[75.0, 149.0, 1137.0, 427.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +18,3,figure_title,TABLE 3 (CONTINUED),"[71.0, 126.0, 224.0, 145.0]",table_caption,0.9,"[""table prefix matched: TABLE 3 (CONTINUED)""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +18,4,table,"
Trigger modeElectroactive materialsPiezoelectric effectEffectHighlightsRef.
MagnetostrictionWhitlockit","[75.0, 149.0, 1137.0, 427.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 18,5,figure_title,(b),"[543.0, 559.0, 572.0, 582.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True -18,6,image,,"[85.0, 546.0, 1125.0, 1192.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +18,6,image,,"[85.0, 546.0, 1125.0, 1192.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 18,7,paragraph_title,FIG. 6,"[73.0, 1200.0, 123.0, 1219.0]",figure_caption,0.9,"[""figure prefix matched: FIG. 6""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True 18,8,figure_title,"A) schematic diagram of the response of polarized and non-polarized surfaces to cell-material interactions. Reproduced with permission [237]. Copyright 2013, Wiley-VCH. b) GaN/AlGaN films with surface","[69.0, 1224.0, 1144.0, 1346.0]",figure_caption_candidate,0.85,"[""figure_title label: A) schematic diagram of the response of polarized and non-po""]",figure_caption,0.85,body_zone,support_like,none,False,False 18,9,text,"PLGA film and MXene/PVDF film with a surface potential of $ -76.8\ mV $, $ -58.2 $ to $ 60.9\ mV $ and $ -58.6 $ to $ -74.58\ mV $, respectively [165,240,241].","[68.0, 1381.0, 594.0, 1450.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 18,10,text,"However, some studies hold the opposite view, suggesting that positively charged surfaces are more favor to bone formation. In the same polarized lithium niobate, better cell adhesion and spread capab","[69.0, 1453.0, 594.0, 1500.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -18,11,text,,"[616.0, 1382.0, 1145.0, 1500.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +18,11,text,"tion. In the same polarized lithium niobate, better cell adhesion +and spread capabilities were observed on its positively charged +surface. By measuring proteins adsorbed on the charged surface, +more p","[616.0, 1382.0, 1145.0, 1500.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 18,12,number,194,"[72.0, 1536.0, 103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 19,0,header,Materials Today • Volume 68 • September 2023,"[81.0, 61.0, 422.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 19,1,header,RESEARCH,"[1071.0, 61.0, 1154.0, 80.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -251,7 +298,10 @@ Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection 19,4,text,There are also some piezoelectric materials that are intrinsically neutral and only generate an electric charge/potential in response to a force. The magnitude of the piezoelectric signal generated in,"[78.0, 793.0, 605.0, 982.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 19,5,text,Cell traction. It is well known that the intracellular tension generated during cell spreading and migration can be anchored to the substrate through actin and stress fibers. This traction force is us,"[78.0, 984.0, 606.0, 1293.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 19,6,text,Constant cyclic stress. External dynamic loads can also be used to simulate the physiological load generated by the human body's daily activities to trigger the piezoelectricity of materials. As shown,"[78.0, 1295.0, 606.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -19,7,text,,"[626.0, 123.0, 1156.0, 290.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +19,7,text,"soidal waveform at 1 Hz was used to apply dynamic compressive +stress of 10% compression deformation to the 3D nanofiber scaf- +fold. The streaming potentials of annealed P(VDF-TrFE) was 61. +1 ± 1.5 lV, ","[626.0, 123.0, 1156.0, 290.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 19,8,text,"US stimulation. As a non-invasive approach, US has deep tissue penetration and biological safety, and can be used to trigger piezoelectric effects remotely and accurately. US has been applied to PLLA ","[627.0, 291.0, 1156.0, 624.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 19,9,text,"Magnetostriction. Extensive studies have demonstrated that stem cells can achieve osteogenic differentiation, chondrogenic differentiation, and neural differentiation in response to electromagnetic fi","[626.0, 626.0, 1157.0, 1127.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 19,10,paragraph_title,Triboelectric nanogenerators (TENG),"[630.0, 1153.0, 894.0, 1174.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Triboelectric nanogenerators (TENG)""]",subsection_heading,0.6,body_zone,body_like,none,True,True @@ -261,25 +311,31 @@ Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection 20,0,header,RESEARCH,"[72.0, 61.0, 154.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 20,1,aside_text,RESEARCH: Review,"[25.0, 342.0, 42.0, 484.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True 20,2,header,Materials Today • Volume 68 • September 2023,"[803.0, 61.0, 1142.0, 80.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -20,3,image,,"[70.0, 125.0, 1125.0, 803.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,3,image,,"[70.0, 125.0, 1125.0, 803.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 20,4,figure_title,"A) saos-2 cells growing on zinc oxide nanosheets trigger the piezoelectric effect through their own traction. Reproduced with permission[169]. Copyright 2020, Wiley-VCH. b) The piezoelectric effect is","[68.0, 838.0, 1143.0, 942.0]",figure_caption_candidate,0.85,"[""figure_title label: A) saos-2 cells growing on zinc oxide nanosheets trigger the""]",figure_caption,0.85,body_zone,support_like,none,False,False 20,5,text,"of a heartbeat, convert it into electrical energy, store it, and then apply it to the pacemaker [254,255].","[68.0, 961.0, 593.0, 1007.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 20,6,text,The first study using TENG to induce bone formation was achieved by seeding MC3T3-E1 cells on the interdigitated electrode. The rectified output current generated by TENG could reach 1.6 $ \mu $A. As,"[67.0, 1008.0, 595.0, 1461.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 20,7,text,"Bioresorbable self-powered devices, fracture ES devices (FED), have been developed, which can convert body movement into biphasic electrical pulses, which are directly applied to the fracture site thr","[68.0, 1462.0, 594.0, 1509.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -20,8,text,,"[615.0, 961.0, 1145.0, 1078.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +20,8,text,"biphasic electrical pulses, which are directly applied to the frac- +ture site through dressing electrodes. With the help of FED, the +tibial fracture of the rat fully recovered within six weeks and +mai","[615.0, 961.0, 1145.0, 1078.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 20,9,text,"The aging of bones can seriously affect the life quality of the elders, especially leading to osteoporosis-related fractures, which increase the risk of death. The main reason is the decline in the fu","[615.0, 1080.0, 1145.0, 1390.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 20,10,paragraph_title,Other implantable energy harvesting devices,"[619.0, 1416.0, 945.0, 1437.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Other implantable energy harvesting devices""]",subsection_heading,0.6,body_zone,body_like,none,True,True 20,11,text,"In addition to PENG and TENG, which can convert the body's mechanical energy into electrical energy, there are other implantable energy harvesting devices that can collect ambient light or","[617.0, 1436.0, 1145.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 20,12,number,196,"[72.0, 1536.0, 103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 21,0,header,Materials Today • Volume 68 • September 2023,"[82.0, 62.0, 421.0, 80.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 21,1,header,RESEARCH,"[1072.0, 62.0, 1153.0, 78.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -21,2,image,,"[101.0, 125.0, 1128.0, 754.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +21,2,image,,"[101.0, 125.0, 1128.0, 754.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 21,3,figure_title,FIG. 8,"[85.0, 774.0, 135.0, 792.0]",figure_caption,0.92,"[""figure_title label: FIG. 8""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 21,4,figure_title,"A) teng can rejuvenate the aging mesenchymal stem cells[257]. Copyright 2021, Wiley-VCH. b) The ES of photovoltaic cells induces cytosolic Ca²⁺ transients to promote the adhesion and growth of Saos-2 ","[78.0, 797.0, 1156.0, 880.0]",figure_caption_candidate,0.85,"[""figure_title label: A) teng can rejuvenate the aging mesenchymal stem cells[257]""]",figure_caption,0.85,body_zone,support_like,none,False,False 21,5,text,temperature or in vivo redox reactions and convert them into electrical signals.,"[79.0, 917.0, 604.0, 961.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,6,text,"Due to the biosafety of light, light-induced electrical signals have also been applied in the field of bone regeneration. Photovoltaic solar cells have been widely studied as green energy sources. The","[79.0, 962.0, 606.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,7,text,"Ti metal, as a load-bearing bone material that has been used in the clinic, still has the problem of insufficient bioactivity, which results in limited osseointegration. The bioactivity of Ti implants","[79.0, 1442.0, 605.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -21,8,text,,"[627.0, 915.0, 1156.0, 1368.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +21,8,text,"results in limited osseointegration. The bioactivity of Ti implants +can be improved by imparting electrical activity to their surface. +Studies have shown that collagen and HAp could form a semi- +condu","[627.0, 915.0, 1156.0, 1368.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,9,text,"The biggest challenge in applying light to tissue engineering is the penetrability of light. Most optoelectronic materials respond to ultraviolet light and visible light, but the tissue penetration de","[626.0, 1370.0, 1156.0, 1490.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,10,aside_text,RESEARCH: Review,"[1182.0, 342.0, 1199.0, 481.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True 21,11,number,197,"[1123.0, 1536.0, 1153.0, 1554.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -292,7 +348,10 @@ Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection 22,6,paragraph_title,Calcium signaling in cells,"[69.0, 721.0, 289.0, 743.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Calcium signaling in cells""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 22,7,text,"The immediate effect of ES on cells is the intracellular Ca²⁺ levels, which mediates many crucial cellular processes, such as apoptosis, migration, proliferation, and differentiation [264]. When cells","[66.0, 745.0, 594.0, 1007.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,8,text,"According to membrane potentials, voltage-operated calcium channels are divided into low voltage-activated (LVA) and high voltage-activated (HVA). LVA responds to small changes in resting membrane pot","[66.0, 1010.0, 594.0, 1511.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -22,9,text,,"[614.0, 121.0, 1145.0, 601.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +22,9,text,"Ca2+ in the cytoplasm binds to the Ca2+-binding protein, +calmodulin (CaM). CaM can act as a calcium sensor and signal +transducer, binding and activating target proteins that cannot +bind to calcium by ","[614.0, 121.0, 1145.0, 601.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,10,text,The CaM/Cn/NFAT signal pathway mediated by $ Ca^{2+} $ influx is a widely recognized mechanism. It has been confirmed in many works such as external ES mediated by conductive substrates and in-situ E,"[617.0, 600.0, 1144.0, 721.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,11,paragraph_title,Surface receptor redistribution,"[618.0, 744.0, 879.0, 767.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Surface receptor redistribution""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 22,12,text,"Membrane proteins, as signal integrators, can respond to extracellular stimuli and changes in transmembrane potential [270]. The ES-induced cascade may be realized by the redistribution of charged cel","[616.0, 769.0, 1144.0, 912.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -301,7 +360,7 @@ Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection 22,15,number,198,"[72.0, 1536.0, 103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 23,0,header,Materials Today • Volume 68 • September 2023,"[82.0, 61.0, 421.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 23,1,header,RESEARCH,"[1072.0, 61.0, 1154.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -23,2,image,,"[96.0, 136.0, 1130.0, 849.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,2,image,,"[96.0, 136.0, 1130.0, 849.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 23,3,figure_title,FIG. 9,"[85.0, 859.0, 135.0, 878.0]",figure_caption,0.92,"[""figure_title label: FIG. 9""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 23,4,figure_title,Summary of the mechanism of cell response induced by electrical stimulation.,"[81.0, 884.0, 631.0, 906.0]",figure_caption_candidate,0.85,"[""figure_title label: Summary of the mechanism of cell response induced by electri""]",figure_caption,0.85,body_zone,legend_like,none,False,False 23,5,text,"pathway, which has been proven to promote bone formation under pulsed electromagnetic fields [248,271].","[79.0, 942.0, 604.0, 988.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -309,7 +368,10 @@ Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection 23,7,text,Studies have also found that the expression of cadherin 16 (Cdh16) was up-regulated after MSCs were seeded on BFO $ ^{+} $nanofilm for 3 h [242]. Cdh is a transmembrane protein that can mediate cell a,"[78.0, 1134.0, 606.0, 1348.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,8,paragraph_title,Adenosine triphosphate (ATP),"[79.0, 1390.0, 335.0, 1413.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Adenosine triphosphate (ATP)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 23,9,text,The ATPase on the membrane can absorb energy from ES of specific frequency and amplitude to regulate the activity of membrane proteins. The mitochondrial membrane that receives the electrical signal a,"[77.0, 1415.0, 605.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -23,10,text,,"[626.0, 941.0, 1156.0, 1348.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +23,10,text,"ation process usually requires a large amount of ATP. The work of +ES to drive MSCs' cartilage formation shows that ES can directly +induce MSCs to produce Ca2+/ATP oscillations. The purinergic +receptor","[626.0, 941.0, 1156.0, 1348.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,11,paragraph_title,Reactive oxygen species (ROS),"[630.0, 1390.0, 889.0, 1413.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Reactive oxygen species (ROS)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 23,12,text,"The production of ROS may be another mechanism by which cells respond to electrical signals. Mitochondria are the main source of endogenous ROS, and a small portion of the electrons leak out from the ","[626.0, 1415.0, 1156.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,13,aside_text,RESEARCH: Review,"[1183.0, 341.0, 1199.0, 481.0]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True @@ -322,19 +384,22 @@ Piezoelectric nanogenerators (PENG)","[628.0, 1154.0, 950.0, 1198.0]",subsection 24,5,paragraph_title,Conclusions and outlook,"[68.0, 623.0, 318.0, 646.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conclusions and outlook""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 24,6,text,"As an important part of organisms, ENEF plays an indispensable role in regulating growth and development and mediating signal transmission. However, unlike neurons and cardiomyocytes, bone cells canno","[67.0, 651.0, 594.0, 1102.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,7,text,"Although a series of conductive materials have been developed as substrates for delivering electrical signals to cells, they can also provide other biophysical and biochemical cues to achieve synerget","[67.0, 1103.0, 595.0, 1509.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -24,8,text,,"[614.0, 122.0, 1145.0, 673.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +24,8,text,"Drug Administration (FDA) has approved a series of bone growth +ES devices since 1979 for the treatment of bone-related diseases +such as nonunion of fractures, congenital false joints, spinal +fusion, a","[614.0, 122.0, 1145.0, 673.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,9,text,"In this case, the importance of self-powered ES devices has been highlighted. Piezoelectric materials do not require the implantation of electrodes and wires, which is a relatively safer choice. Altho","[614.0, 674.0, 1147.0, 1510.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,10,number,200,"[71.0, 1536.0, 103.0, 1553.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 25,0,header,Materials Today • Volume 68 • September 2023,"[81.0, 61.0, 421.0, 81.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 25,1,header,RESEARCH,"[1071.0, 62.0, 1154.0, 79.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 25,2,text,"ideal TENG for bone regeneration should be completely sealed, with no exposed wires, and only a multifunctional conductive interface with nano-topography that contact cells is exposed. Furthermore, th","[78.0, 122.0, 606.0, 360.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 25,3,text,"Compared with other synergistic therapies, ES treatment has gained a head start with years of clinical experience. However, expensive treatment costs and long treatment cycles still limit its applicat","[78.0, 362.0, 606.0, 626.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -25,4,paragraph_title,Data availability,"[81.0, 652.0, 247.0, 675.0]",backmatter_heading,0.8,"[""backmatter heading on page 25: Data availability""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -25,5,text,Data will be made available on request.,"[104.0, 678.0, 406.0, 699.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -25,6,paragraph_title,Declaration of Competing Interest,"[80.0, 723.0, 420.0, 745.0]",section_heading,0.5,"[""backmatter heading on page 25: Declaration of Competing Interest""]",backmatter_heading_candidate,0.8,body_zone,heading_like,none,True,True -25,7,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[79.0, 749.0, 605.0, 813.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -25,8,paragraph_title,Acknowledgements,"[81.0, 836.0, 278.0, 858.0]",section_heading,0.5,"[""backmatter heading on page 25: Acknowledgements""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -25,9,text,"This work is supported by the Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award (Grant No. 113548; to W. T.), Harvard Medical School/Brigham and Women's Hospital D","[77.0, 863.0, 607.0, 1198.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,4,paragraph_title,Data availability,"[81.0, 652.0, 247.0, 675.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data availability""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +25,5,text,Data will be made available on request.,"[104.0, 678.0, 406.0, 699.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,6,paragraph_title,Declaration of Competing Interest,"[80.0, 723.0, 420.0, 745.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Declaration of Competing Interest""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +25,7,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[79.0, 749.0, 605.0, 813.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,8,paragraph_title,Acknowledgements,"[81.0, 836.0, 278.0, 858.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +25,9,text,"This work is supported by the Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award (Grant No. 113548; to W. T.), Harvard Medical School/Brigham and Women's Hospital D","[77.0, 863.0, 607.0, 1198.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 25,10,paragraph_title,References,"[80.0, 1218.0, 169.0, 1238.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True 25,11,reference_content,"[1] X. Zhang et al., Matter 4 (9) (2021) 2727.","[95.0, 1245.0, 381.0, 1261.0]",reference_item,0.85,"[""reference content label: [1] X. Zhang et al., Matter 4 (9) (2021) 2727.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 25,12,reference_content,"[2] G.L. Koons et al., Nat. Rev. Mater. 5 (8) (2020) 584.","[95.0, 1263.0, 443.0, 1281.0]",reference_item,0.85,"[""reference content label: [2] G.L. Koons et al., Nat. Rev. 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However, clinical intervention will be necessary when the ", - "found_in_fulltext": true, - "fulltext_offset": 2800 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p2:4", @@ -210,8 +220,18 @@ "zone": "body_zone", "render_default": true, "snippet": "It is well known that the endogenous electric field (EnEF) plays a guiding role ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:5", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "structure [14], which can convert the compressive load generated by physiologica", "found_in_fulltext": true, - "fulltext_offset": 3614 + "fulltext_offset": 3174 }, { "block_id": "p2:6", @@ -220,8 +240,8 @@ "zone": "body_zone", "render_default": true, "snippet": "In this context, electroactive biomaterials (EABMs) have emerged. EABMs are a ne", - "found_in_fulltext": true, - "fulltext_offset": 4759 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p2:8", @@ -241,7 +261,7 @@ "render_default": false, "snippet": "178", "found_in_fulltext": true, - "fulltext_offset": 55444 + "fulltext_offset": 80591 }, { "block_id": "p3:0", @@ -270,8 +290,8 @@ "zone": "body_zone", "render_default": true, "snippet": "ultrasound, mechanical vibrations, etc.) [33–37]. Thus, piezoelectric biomateria", - "found_in_fulltext": true, - "fulltext_offset": 6518 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:3", @@ -280,8 +300,8 @@ "zone": "body_zone", "render_default": true, "snippet": "This review outlines the latest progress of EABMs in BTE. 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Piezoele", "found_in_fulltext": true, - "fulltext_offset": 10230 + "fulltext_offset": 4330 }, { "block_id": "p3:10", @@ -341,7 +371,7 @@ "render_default": true, "snippet": "The piezoelectricity of bone tissue is attributed to collagen molecules with non", "found_in_fulltext": true, - "fulltext_offset": 11069 + "fulltext_offset": 5169 }, { "block_id": "p3:11", @@ -351,7 +381,7 @@ "render_default": true, "snippet": "Cellular response to electric signals", "found_in_fulltext": true, - "fulltext_offset": 12935 + "fulltext_offset": 7035 }, { "block_id": "p3:12", @@ -361,7 +391,7 @@ "render_default": true, "snippet": "ES has a long history in the treatment of fractures, dating back to the mid-nine", "found_in_fulltext": true, - "fulltext_offset": 12973 + "fulltext_offset": 7073 }, { "block_id": "p3:13", @@ -381,7 +411,7 @@ "render_default": false, "snippet": "179", "found_in_fulltext": true, - "fulltext_offset": 120672 + "fulltext_offset": 80648 }, { "block_id": "p4:0", @@ -420,8 +450,8 @@ "zone": "body_zone", "render_default": true, "snippet": "tures, and femoral osteonecrosis [58]. 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Therefore, rep", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:8", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "triphosphate (ATP) and free calcium will further increase the contractility of t", "found_in_fulltext": true, - "fulltext_offset": 15901 + "fulltext_offset": 9586 }, { "block_id": "p4:9", @@ -471,7 +511,7 @@ "render_default": true, "snippet": "Cell migration", "found_in_fulltext": true, - "fulltext_offset": 17579 + "fulltext_offset": 10413 }, { "block_id": "p4:10", @@ -481,7 +521,7 @@ "render_default": true, "snippet": "Inducing the migration of endogenous cells to the wound site is conducive to the", "found_in_fulltext": true, - "fulltext_offset": 17594 + "fulltext_offset": 10428 }, { "block_id": "p4:11", @@ -491,7 +531,7 @@ "render_default": true, "snippet": "Cell adhesion", "found_in_fulltext": true, - "fulltext_offset": 18663 + "fulltext_offset": 11497 }, { "block_id": "p4:12", @@ -501,7 +541,7 @@ "render_default": true, "snippet": "Cell adhesion is mainly used to describe the interaction between the cytoskeleto", "found_in_fulltext": true, - "fulltext_offset": 18677 + "fulltext_offset": 11511 }, { "block_id": "p4:13", @@ -511,7 +551,7 @@ "render_default": true, "snippet": "Osteogenic differentiation", "found_in_fulltext": true, - "fulltext_offset": 19602 + "fulltext_offset": 12436 }, { "block_id": "p4:14", @@ -521,7 +561,7 @@ "render_default": true, "snippet": "In view of the electroactivity of bone, numerous pieces of evidence has proved t", "found_in_fulltext": true, - "fulltext_offset": 19629 + "fulltext_offset": 12463 }, { "block_id": "p4:15", @@ -531,7 +571,7 @@ "render_default": false, "snippet": "180", "found_in_fulltext": true, - "fulltext_offset": 114119 + "fulltext_offset": 74144 }, { "block_id": "p5:0", @@ -560,8 +600,8 @@ "zone": "body_zone", "render_default": true, "snippet": "tion of stem cells [84–88]. 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Carbon nanotubes, both single-walled carbon nanotubes (SWCNTs)", "found_in_fulltext": true, - "fulltext_offset": 21390 + "fulltext_offset": 13240 + }, + { + "block_id": "p5:10", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "properties (Young’s modulus up to 1 TPa and tensile strength of 63 GPa). Moreove", + "found_in_fulltext": true, + "fulltext_offset": 14429 }, { "block_id": "p5:11", @@ -631,7 +681,7 @@ "render_default": true, "snippet": "Despite the as-explored promising applications in biomedical engineering, the sa", "found_in_fulltext": true, - "fulltext_offset": 22579 + "fulltext_offset": 15076 }, { "block_id": "p5:12", @@ -641,7 +691,7 @@ "render_default": true, "snippet": "Graphene and its derivatives. 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Under physiologically relevant low frequencies, the impedance of G", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p9:5", @@ -1161,15 +1251,15 @@ "render_default": true, "snippet": "Carbon-based nanomaterials have also been shown to interact with osteoblasts to ", "found_in_fulltext": true, - "fulltext_offset": 47958 + "fulltext_offset": 28912 }, { - "block_id": "p9:7", + "block_id": "p9:6", "page": 9, - "role": "media_asset", - "zone": "body_zone", + "role": "table_caption", + "zone": "display_zone", "render_default": true, - "snippet": "
Electrical properties of electroactive scaffolds and ", + "snippet": "TABLE 1", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -1191,7 +1281,7 @@ "render_default": false, "snippet": "185", "found_in_fulltext": true, - "fulltext_offset": 56311 + "fulltext_offset": 33394 }, { "block_id": "p10:0", @@ -1241,7 +1331,7 @@ "render_default": true, "snippet": "membrane with a core–shell structure demonstrates enhanced adhesion properties f", "found_in_fulltext": true, - "fulltext_offset": 49126 + "fulltext_offset": 30112 }, { "block_id": "p10:6", @@ -1250,8 +1340,8 @@ "zone": "body_zone", "render_default": true, "snippet": "As bone implants, redox reactions on carbon steel surfaces may cause adverse eff", - "found_in_fulltext": true, - "fulltext_offset": 49222 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p10:7", @@ -1260,8 +1350,18 @@ "zone": "body_zone", "render_default": true, "snippet": "As natural bones have piezoelectricity, piezoelectric materials that can respond", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p10:8", + "page": 10, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "fields inside bone tissue, making them theoretically more suit- able for bone reg", "found_in_fulltext": true, - "fulltext_offset": 49808 + "fulltext_offset": 30208 }, { "block_id": "p10:9", @@ -1271,7 +1371,7 @@ "render_default": true, "snippet": "Barium titanate (BT) with a high piezoelectrical coefficient is the most popular", "found_in_fulltext": true, - "fulltext_offset": 50224 + "fulltext_offset": 30527 }, { "block_id": "p10:10", @@ -1281,7 +1381,7 @@ "render_default": false, "snippet": "186", "found_in_fulltext": true, - "fulltext_offset": 56519 + "fulltext_offset": 33602 }, { "block_id": "p11:0", @@ -1310,8 +1410,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Compared with pure P(VDF-TrFE) film, the piezoelectric film doped with 5% BT NPs", - "found_in_fulltext": true, - "fulltext_offset": 50787 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p11:3", @@ -1320,8 +1420,8 @@ "zone": "body_zone", "render_default": true, "snippet": "ZnO is also a common EABM used for bone repair. 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Effects of in situ electrical stimulation generated b", + "snippet": "TABLE 3", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -1971,7 +2131,7 @@ "render_default": false, "snippet": "193", "found_in_fulltext": true, - "fulltext_offset": 59112 + "fulltext_offset": 35744 }, { "block_id": "p18:0", @@ -2004,12 +2164,12 @@ "fulltext_offset": -1 }, { - "block_id": "p18:4", + "block_id": "p18:3", "page": 18, - "role": "media_asset", - "zone": "body_zone", + "role": "table_caption", + "zone": "display_zone", "render_default": true, - "snippet": "
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In the same polarized lithium niobate, better cell adhesion and spread cap", + "found_in_fulltext": true, + "fulltext_offset": 49335 }, { "block_id": "p18:12", @@ -2051,7 +2221,7 @@ "render_default": false, "snippet": "194", "found_in_fulltext": true, - "fulltext_offset": 10475 + "fulltext_offset": 4575 }, { "block_id": "p19:0", @@ -2080,8 +2250,8 @@ "zone": "body_zone", "render_default": true, "snippet": "showed negatively charged in osteogenic induction medium, thereby enhancing the ", - "found_in_fulltext": true, - "fulltext_offset": 79425 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:3", @@ -2090,8 +2260,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Although there are different opinions on the effects of positive and negative ch", - "found_in_fulltext": true, - "fulltext_offset": 80523 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:4", @@ -2100,8 +2270,8 @@ "zone": "body_zone", "render_default": true, "snippet": "There are also some piezoelectric materials that are intrinsically neutral and o", - "found_in_fulltext": true, - "fulltext_offset": 81157 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:5", @@ -2111,7 +2281,7 @@ "render_default": true, "snippet": "Cell traction. 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Pi", "found_in_fulltext": true, - "fulltext_offset": 105940 + "fulltext_offset": 67667 }, { "block_id": "p24:10", @@ -2751,7 +2981,7 @@ "render_default": false, "snippet": "200", "found_in_fulltext": true, - "fulltext_offset": 12167 + "fulltext_offset": 6267 }, { "block_id": "p25:0", @@ -2780,8 +3010,8 @@ "zone": "body_zone", "render_default": true, "snippet": "ideal TENG for bone regeneration should be completely sealed, with no exposed wi", - "found_in_fulltext": true, - "fulltext_offset": 108184 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:3", @@ -2790,38 +3020,38 @@ "zone": "body_zone", "render_default": true, "snippet": "Compared with other synergistic therapies, ES treatment has gained a head start ", - "found_in_fulltext": true, - "fulltext_offset": 108827 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:4", "page": 25, - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Data availability", - "found_in_fulltext": true, - "fulltext_offset": 109531 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:5", "page": 25, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "Data will be made available on request.", "found_in_fulltext": true, - "fulltext_offset": 109551 + "fulltext_offset": 69911 }, { "block_id": "p25:6", "page": 25, - "role": "section_heading", + "role": "backmatter_heading", "zone": "body_zone", "render_default": true, "snippet": "Declaration of Competing Interest", - "found_in_fulltext": true, - "fulltext_offset": 109474 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:7", @@ -2830,18 +3060,18 @@ "zone": "body_zone", "render_default": true, "snippet": "The authors declare that they have no known competing financial interests or per", - "found_in_fulltext": true, - "fulltext_offset": 109591 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:8", "page": 25, - "role": "section_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Acknowledgements", "found_in_fulltext": true, - "fulltext_offset": 109510 + "fulltext_offset": 69953 }, { "block_id": "p25:9", @@ -2851,7 +3081,7 @@ "render_default": true, "snippet": "This work is supported by the Gillian Reny Stepping Strong Center for Trauma Inn", "found_in_fulltext": true, - "fulltext_offset": 109762 + "fulltext_offset": 69972 }, { "block_id": "p25:10", @@ -2861,7 +3091,7 @@ "render_default": true, "snippet": "References", "found_in_fulltext": true, - "fulltext_offset": 112353 + "fulltext_offset": 72378 }, { "block_id": "p25:11", @@ -2871,7 +3101,7 @@ "render_default": true, "snippet": "[1] X. 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Schmelter et al., FASEB J. 20 (8) (2006) 1182.", "found_in_fulltext": true, - "fulltext_offset": 126056 + "fulltext_offset": 85707 }, { "block_id": "p27:42", @@ -5521,7 +5751,7 @@ "render_default": true, "snippet": "[273] C. Zhang et al., Adv. Healthc. Mater. 7 (11) (2018) 1701466.", "found_in_fulltext": true, - "fulltext_offset": 126112 + "fulltext_offset": 85763 }, { "block_id": "p27:43", @@ -5531,7 +5761,7 @@ "render_default": true, "snippet": "[274] Y. Qian et al., Small 16 (32) (2020) 2000796.", "found_in_fulltext": true, - "fulltext_offset": 126179 + "fulltext_offset": 85830 }, { "block_id": "p27:44", @@ -5541,7 +5771,7 @@ "render_default": true, "snippet": "[275] J Zhou et al., Exploration 1 (2021) 20210011.", "found_in_fulltext": true, - "fulltext_offset": 126231 + "fulltext_offset": 85882 }, { "block_id": "p27:45", @@ -5551,7 +5781,7 @@ "render_default": true, "snippet": "[276] X Wan et al., Exploration 2 (2022) 20210029.", "found_in_fulltext": true, - "fulltext_offset": 126283 + "fulltext_offset": 85934 }, { "block_id": "p27:46", @@ -5561,7 +5791,7 @@ "render_default": true, "snippet": "[277] Y Bian et al., Exploration 3 (2023) 20210105.", "found_in_fulltext": true, - "fulltext_offset": 126334 + "fulltext_offset": 85985 }, { "block_id": "p27:47", @@ -5571,7 +5801,7 @@ "render_default": true, "snippet": "[278] Y Zhang et al., Exploration 1 (2021) 90.", "found_in_fulltext": true, - "fulltext_offset": 126386 + "fulltext_offset": 86037 }, { "block_id": "p27:48", @@ -5581,7 +5811,7 @@ "render_default": true, "snippet": "[279] S Li et al., Exploration 2 (2022) 20210223.", "found_in_fulltext": true, - "fulltext_offset": 126433 + "fulltext_offset": 86084 }, { "block_id": "p27:49", @@ -5591,7 +5821,7 @@ "render_default": false, "snippet": "203", "found_in_fulltext": true, - "fulltext_offset": 121895 + "fulltext_offset": 81871 }, { "block_id": "p27:50", diff --git a/audit/KIX7SKXQ/page_risk_summary.json b/audit/KIX7SKXQ/page_risk_summary.json index ce711d48..b77a35da 100644 --- a/audit/KIX7SKXQ/page_risk_summary.json +++ b/audit/KIX7SKXQ/page_risk_summary.json @@ -2,221 +2,33 @@ "pages": [ { "page": 1, - "risk_score": 7, + "risk_score": 5, "risk_reasons": [ - "frontmatter_page", - "unknown_structural_threshold" + "frontmatter_page" ], "recommended_audit_targets": [ - "body_flow", "frontmatter" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, - "hold": 1, - "unknown_structural": 2, + "hold": 0, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } }, { "page": 2, - "risk_score": 5, + "risk_score": 3, "risk_reasons": [ - "reader_object_gap", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", - "object_ownership" - ], - "counts": { - "body_paragraph": 3, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, - "table_like": 0, - "captions": 1, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 1, - "ambiguous_figures": 0 - } - }, - { - "page": 3, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], - "counts": { - "body_paragraph": 7, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 4, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], - "counts": { - "body_paragraph": 6, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 5, - "risk_score": 5, - "risk_reasons": [ - "reader_object_gap", - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow", - "object_ownership" - ], - "counts": { - "body_paragraph": 6, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, - "table_like": 0, - "captions": 1, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 1, - "ambiguous_figures": 0 - } - }, - { - "page": 6, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], - "counts": { - "body_paragraph": 7, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 7, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], - "counts": { - "body_paragraph": 9, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 8, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], - "counts": { - "body_paragraph": 8, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 9, - "risk_score": 12, - "risk_reasons": [ - "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap", - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow", - "object_ownership" - ], - "counts": { - "body_paragraph": 3, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, - "table_like": 2, - "captions": 1, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 10, - "risk_score": 5, - "risk_reasons": [ - "reader_object_gap", - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow", "object_ownership" ], "counts": { @@ -227,20 +39,16 @@ "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, + "unknown_structural": 1, + "matched_figures": 1, "ambiguous_figures": 0 } }, { - "page": 11, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], + "page": 3, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { "body_paragraph": 8, "reference_item": 0, @@ -249,66 +57,16 @@ "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 2, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } }, { - "page": 12, - "risk_score": 5, - "risk_reasons": [ - "reader_object_gap", - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow", - "object_ownership" - ], - "counts": { - "body_paragraph": 3, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, - "table_like": 0, - "captions": 1, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 13, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], - "counts": { - "body_paragraph": 8, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 14, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], + "page": 4, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { "body_paragraph": 7, "reference_item": 0, @@ -317,22 +75,237 @@ "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 2, + "unknown_structural": 1, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 5, + "risk_score": 3, + "risk_reasons": [ + "reader_object_gap" + ], + "recommended_audit_targets": [ + "object_ownership" + ], + "counts": { + "body_paragraph": 7, + "reference_item": 0, + "tail_like": 0, + "media_assets": 1, + "table_like": 0, + "captions": 1, + "hold": 0, + "unknown_structural": 1, + "matched_figures": 1, + "ambiguous_figures": 0 + } + }, + { + "page": 6, + "risk_score": 0, + "risk_reasons": [], + 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"caption_asset_mismatch" + ], + "recommended_audit_targets": [ + "object_ownership" + ], + "counts": { + "body_paragraph": 4, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 2, + "captions": 1, + "hold": 0, + "unknown_structural": 1, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 10, + "risk_score": 3, + "risk_reasons": [ + "reader_object_gap" + ], + "recommended_audit_targets": [ + "object_ownership" + ], + "counts": { + "body_paragraph": 5, + "reference_item": 0, + "tail_like": 0, + "media_assets": 1, + "table_like": 0, + "captions": 1, + "hold": 0, + "unknown_structural": 1, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 11, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], + "counts": { + "body_paragraph": 9, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 0, + "captions": 0, + "hold": 0, + "unknown_structural": 1, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 12, + "risk_score": 3, + "risk_reasons": [ + "reader_object_gap" + ], + "recommended_audit_targets": [ + "object_ownership" + ], + "counts": { + "body_paragraph": 4, + "reference_item": 0, + "tail_like": 0, + "media_assets": 1, + "table_like": 0, + "captions": 1, + "hold": 0, + "unknown_structural": 1, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 13, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], + "counts": { + "body_paragraph": 9, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 0, + "captions": 0, + "hold": 0, + "unknown_structural": 1, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 14, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], + "counts": { + "body_paragraph": 8, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 0, + "captions": 0, + "hold": 0, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } }, { "page": 15, - "risk_score": 12, + "risk_score": 4, "risk_reasons": [ - "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap", - "unknown_structural_threshold" + "multi_asset_page" + ], + "recommended_audit_targets": [ + "object_ownership" + ], + "counts": { + "body_paragraph": 4, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 2, + "captions": 2, + "hold": 0, + "unknown_structural": 1, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 16, + "risk_score": 3, + "risk_reasons": [ + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "object_ownership" ], "counts": { @@ -340,45 +313,19 @@ "reference_item": 0, "tail_like": 0, "media_assets": 1, - "table_like": 2, - "captions": 2, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 16, - "risk_score": 5, - "risk_reasons": [ - "reader_object_gap", - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow", - "object_ownership" - ], - "counts": { - "body_paragraph": 2, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 2, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } }, { "page": 17, - "risk_score": 10, + "risk_score": 4, "risk_reasons": [ - "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap" + "multi_asset_page" ], "recommended_audit_targets": [ "object_ownership" @@ -387,7 +334,7 @@ "body_paragraph": 0, "reference_item": 0, "tail_like": 0, - "media_assets": 1, + "media_assets": 0, "table_like": 2, "captions": 2, "hold": 0, @@ -398,166 +345,145 @@ }, { "page": 18, - "risk_score": 12, + "risk_score": 7, "risk_reasons": [ "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, - "media_assets": 2, + "media_assets": 1, "table_like": 2, "captions": 3, "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 1 + "unknown_structural": 1, + "matched_figures": 1, + "ambiguous_figures": 0 } }, { "page": 19, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { - "body_paragraph": 8, + "body_paragraph": 9, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 2, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } }, { "page": 20, - "risk_score": 5, + "risk_score": 3, "risk_reasons": [ - "reader_object_gap", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "object_ownership" ], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 2, - "matched_figures": 1, + "unknown_structural": 1, + "matched_figures": 0, "ambiguous_figures": 0 } }, { "page": 21, - "risk_score": 8, + "risk_score": 6, "risk_reasons": [ "caption_asset_mismatch", - "reader_object_gap", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "object_ownership" ], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 2, "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 1 + "unknown_structural": 1, + "matched_figures": 1, + "ambiguous_figures": 0 } }, { "page": 22, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { - "body_paragraph": 8, + "body_paragraph": 9, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 2, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } }, { "page": 23, - "risk_score": 8, + "risk_score": 6, "risk_reasons": [ "caption_asset_mismatch", - "reader_object_gap", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "object_ownership" ], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 2, "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 2 + "unknown_structural": 1, + "matched_figures": 1, + "ambiguous_figures": 0 } }, { "page": 24, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 2, + "unknown_structural": 1, "matched_figures": 0, "ambiguous_figures": 0 } @@ -576,9 +502,9 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 82, - "tail_like": 5, + "tail_like": 4, "media_assets": 0, "table_like": 0, "captions": 0, @@ -628,28 +554,17 @@ "selected_pages": [ 1, 2, - 3, - 4, 5, - 6, - 7, - 8, 9, 10, - 11, 12, - 13, - 14, 15, 16, 17, 18, - 19, 20, 21, - 22, 23, - 24, 25 ] } \ No newline at end of file diff --git a/audit/KIX7SKXQ/reference_intrusion_candidates.json b/audit/KIX7SKXQ/reference_intrusion_candidates.json index 1052feae..5359a500 100644 --- a/audit/KIX7SKXQ/reference_intrusion_candidates.json +++ b/audit/KIX7SKXQ/reference_intrusion_candidates.json @@ -102,371 +102,371 @@ "block_id": "p25:24", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:25", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:26", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:27", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:28", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": 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+ "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:73", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:74", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:75", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { "block_id": "p25:76", "page": 25, "role": "reference_item", - "zone": "reference_zone", + "zone": "", "reason": "logical_order_between_reference_members" }, { @@ -1609,20 +1609,6 @@ "role": "reference_item", "zone": "reference_zone", "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p27:49", - "page": 27, - "role": "noise", - "zone": "", - "reason": "logical_order_between_reference_members" - }, - { - "block_id": "p27:50", - "page": 27, - "role": "unknown_structural", - "zone": "", - "reason": "logical_order_between_reference_members" } ] } \ No newline at end of file diff --git a/audit/KIX7SKXQ/reference_span_audit.json b/audit/KIX7SKXQ/reference_span_audit.json index a14fe7f3..3261f814 100644 --- a/audit/KIX7SKXQ/reference_span_audit.json +++ b/audit/KIX7SKXQ/reference_span_audit.json @@ -11,8 +11,8 @@ "end": { "page": 27, "column": 2, - "y": 343.0, - "block_id": "p27:50" + "y": 541.0, + "block_id": "p27:48" }, "heading_block_id": "p25:10", "ordered_block_ids": [ @@ -99,8 +99,6 @@ "p25:90", "p25:91", "p25:92", - "p25:93", - "p26:0", "p26:3", "p26:4", "p26:5", @@ -282,8 +280,7 @@ "p27:45", "p27:46", "p27:47", - "p27:48", - "p27:50" + "p27:48" ], "inside_block_ids": [ "p25:10", @@ -369,8 +366,6 @@ "p25:90", "p25:91", "p25:92", - "p25:93", - "p26:0", "p26:3", "p26:4", "p26:5", @@ -552,11 +547,11 @@ "p27:45", "p27:46", "p27:47", - "p27:48", - "p27:50" + "p27:48" ], "explicitly_outside_nearby_block_ids": [ 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"p6:4", + "p6:5", + "p6:6", + "p6:7", + "p6:8", + "p6:9", + "p6:10", + "p6:11", + "p6:12", + "p6:13", + "p6:14", + "p6:15", + "p6:16", + "p6:17", + "p7:0", + "p7:1", + "p7:2", + "p7:3", + "p7:4", + "p7:5", + "p7:6", + "p7:7", + "p7:8", + "p7:9", + "p7:10", + "p7:11", + "p7:12", + "p7:13", + "p7:14", + "p7:15", + "p7:16", + "p8:0", + "p8:1", + "p8:2", + "p8:3", + "p8:4", + "p8:5", + "p8:6", + "p8:7", + "p8:8", + "p8:9", + "p8:10", + "p8:11", + "p8:12", + "p8:13", + "p8:14", + "p8:15", + "p8:16", + "p8:17", + "p8:18", + "p8:19", + "p8:20", + "p8:21", + "p8:22", + "p8:23", + "p8:24" + ], + "findings": [ + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:20" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:21" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:22" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:23" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p8:24" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:0" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:1" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:2" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:3" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:4" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:5" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:6" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:7" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:8" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:9" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:10" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:11" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:12" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:13" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "reference_span_error", + "severity": "critical", + "block_ids": [ + "p9:14" + ], + "truth": "block should remain outside the accepted reference span", + "pipeline_behavior": "block appears inside the logical reference reading-order region", + "root_cause_hypothesis": "logical_order_between_reference_members", + "evidence": { + "annotated_page": "annotated_pages/page_009.png", + "artifact": "reference_span_audit.json" + } + }, + { + "category": "frontmatter_error", + "severity": "major", + "block_ids": [], + "truth": "page 1 should have clearer frontmatter role resolution", + "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", + "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", + "evidence": { + "annotated_page": "annotated_pages/page_001.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", + "evidence": { + "annotated_page": "annotated_pages/page_008.png", + "artifact": "page_risk_summary.json" + } + }, + { + "category": "render_mapping_error", + "severity": "minor", + "block_ids": [ + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:18", + "p1:19", + "p1:22", + "p1:26", + "p1:32", + "p1:33", + "p2:1", + "p2:7" + ], + "truth": "rendered fulltext should be traceable back to source blocks", + "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", + "root_cause_hypothesis": "render omission or snippet mismatch", + "evidence": { + "annotated_page": null, + "artifact": "fulltext_block_mapping_summary.json" + } + } + ] +} \ No newline at end of file diff --git a/audit/KNEBDHHT/audit_report.md b/audit/KNEBDHHT/audit_report.md new file mode 100644 index 00000000..897cd4fc --- /dev/null +++ b/audit/KNEBDHHT/audit_report.md @@ -0,0 +1,38 @@ +# OCR Truth Audit Report - KNEBDHHT + +- Mode: `high-risk` +- Status: `READY` +- Reviewed pages: [1, 3, 4, 5, 6, 7, 8] +- Reviewed blocks: 158 + +## Findings + +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals +- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output + +## Disposition Guidance + +- Use `repair` when the finding reflects a pipeline defect worth fixing now. +- Use `residual` when the finding is real but intentionally deferred. +- Do not rewrite expected truth to make current output look correct. diff --git a/audit/KNEBDHHT/audit_scope.json b/audit/KNEBDHHT/audit_scope.json new file mode 100644 index 00000000..a69940d1 --- /dev/null +++ b/audit/KNEBDHHT/audit_scope.json @@ -0,0 +1,1166 @@ +{ + "mode": "high-risk", + "selected_pages": [ + 1, + 3, + 4, + 5, + 6, + 7, + 8 + ], + "required_block_ids": [ + "p1:0", + "p1:1", + "p1:2", + "p1:3", + "p1:4", + "p1:5", + "p1:6", + "p1:7", + "p1:8", + "p1:9", + "p1:10", + "p1:11", + "p1:12", + "p1:13", + "p1:14", + "p1:15", + "p1:16", + "p1:17", + "p1:18", + "p1:19", + "p1:20", + "p1:21", + "p1:22", + "p1:23", + "p1:24", + "p1:25", + "p1:26", + "p1:27", + "p1:28", + "p1:29", + "p1:30", + "p1:31", + "p1:32", + "p1:33", + "p3:2", + "p3:3", + "p3:5", + "p4:19", + "p5:3", + "p5:5", + "p5:7", + "p5:9", + "p5:11", + "p5:13", + "p5:14", + "p5:16", + "p5:17", + "p6:4", + "p6:6", + "p6:7", + "p6:8", + "p6:10", + "p7:3", + "p7:4", + "p7:6", + "p7:9", + "p7:11", + "p7:12", + "p8:5", + "p8:6", + "p8:11", + "p8:16", + "p8:17", + "p8:19", + "p8:20", + "p8:21", + "p8:22", + "p8:23", + "p8:24" + ], + "required_blocks": [ + { + "block_id": "p1:0", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:1", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:2", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:3", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:4", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:5", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:6", + "page": 1, + "required_reason": [ + "frontmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:7", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:8", + "page": 1, + "required_reason": [ + "frontmatter", + "object_ownership" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:9", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:10", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:11", + "page": 1, + "required_reason": [ + "frontmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p1:12", + "page": 1, + 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206.0, 261.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,Contents lists available at ScienceDirect,"[461.0, 123.0, 753.0, 147.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,header,Materials and Design,"[471.0, 166.0, 742.0, 201.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,5,header,journal homepage: www.elsevier.com/locate/matdes,"[364.0, 235.0, 848.0, 259.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,6,header_image,,"[1010.0, 112.0, 1121.0, 247.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,7,doc_title,Melt electrowriting onto anatomically relevant biodegradable substrates: Resurfacing a diarthrodial joint,"[78.0, 330.0, 958.0, 399.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Melt electrowriting onto anatomically relevant biodegradable""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,8,image,,"[1010.0, 325.0, 1067.0, 382.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,9,text,"Quentin C. Peiffer $ ^{a,b,1} $, Mylène de Ruijter $ ^{a,b,1} $, Joost van Duijn $ ^{a,b} $, Denis Crottet $ ^{c} $, Ernst Dominic $ ^{c} $, Jos Malda $ ^{a,b,d} $, Miguel Castilho $ ^{a,b,e,*} $","[79.0, 413.0, 994.0, 468.0]",authors,0.8,"[""page-1 zone author_zone: Quentin C. Peiffer $ ^{a,b,1} $, Myl\u00e8ne de Ruijter $ ^{a,b,1""]",authors,0.8,body_zone,reference_like,citation_line,True,True +1,10,text," $ ^{a} $ Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, GA, Utrecht, the Netherlands","[79.0, 478.0, 706.0, 497.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $ Department of Orthopaedics, University Medical Cent""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,11,text,"Regenerative Medicine Center Utrecht, Utrecht, the Netherlands","[81.0, 496.0, 444.0, 514.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: Regenerative Medicine Center Utrecht, Utrecht, the Netherlan""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,12,text," $ ^{c} $ RegenHU Ltd, Villaz-St-Pierre, Switzerland","[81.0, 513.0, 327.0, 530.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{c} $ RegenHU Ltd, Villaz-St-Pierre, Switzerland""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,13,text," $ ^{d} $ Department of Clinical Sciences, Faculty of Veterinary Sciences, Utrecht University, Utrecht, the Netherlands","[80.0, 529.0, 680.0, 547.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{d} $ Department of Clinical Sciences, Faculty of Veterin""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,14,text," $ ^{e} $ Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands","[80.0, 546.0, 812.0, 566.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{e} $ Orthopaedic Biomechanics, Department of Biomedical ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,15,paragraph_title,HIGHLIGHTS,"[81.0, 602.0, 229.0, 622.0]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: HIGHLIGHTS""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True +1,16,text,• Microfibre patterning onto an anatomical relevant structure and clinically relevant materials is demonstrated.,"[82.0, 646.0, 354.0, 703.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,17,text,• Accurate microfibre patterning is demonstrated on both electrically conductive and non-conductive materials.,"[82.0, 704.0, 355.0, 761.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,18,text,"• Fabrication of a microfibre-reinforced, cell-laden hydrogel that resurfaces a human biological joint replica is shown","[81.0, 761.0, 356.0, 821.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,19,paragraph_title,ARTICLE INFO,"[80.0, 902.0, 278.0, 922.0]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: ARTICLE INFO""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True +1,20,text,"Article history: +Received 30 May 2020 +Received in revised form 30 July 2020 +Accepted 30 July 2020 +Available online 4 August 2020","[81.0, 941.0, 304.0, 1028.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Article history:\nReceived 30 May 2020\nReceived in revised fo""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,21,text,"Keywords: +Fibre-reinforced hydrogels +Anatomical surfaces +Electrostatics +Electrospinning +Osteochondral defects +Biofabrication","[81.0, 1045.0, 239.0, 1167.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords:\nFibre-reinforced hydrogels\nAnatomical surfaces\nEle""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,22,paragraph_title,GRAPHICAL ABSTRACT,"[410.0, 603.0, 674.0, 622.0]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: GRAPHICAL ABSTRACT""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True +1,23,image,,"[412.0, 718.0, 562.0, 840.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,24,image,,"[622.0, 712.0, 791.0, 862.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,25,image,,"[836.0, 711.0, 1053.0, 853.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,26,paragraph_title,A B S T R A C T,"[410.0, 902.0, 549.0, 922.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: A B S T R A C T""]",section_heading,0.5,body_zone,body_like,short_fragment,True,True +1,27,abstract,Three-dimensional printed hydrogel constructs with well-organized melt electrowritten (MEW) fibre-reinforcing scaffolds have been demonstrated as a promising regenerative approach to treat small carti,"[407.0, 940.0, 1128.0, 1227.0]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,28,text,© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/),"[429.0, 1227.0, 1126.0, 1261.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2020 The Author(s). Published by Elsevier Ltd. This is an ""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,29,paragraph_title,1. Introduction,"[618.0, 1316.0, 737.0, 1337.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +1,30,footnote,"* Corresponding author at: Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, GA, Utrecht, the Netherlands.","[82.0, 1350.0, 590.0, 1385.0]",footnote,0.7,"[""footnote label: * Corresponding author at: Department of Orthopaedics, Unive""]",footnote,0.7,body_zone,body_like,none,True,True +1,31,text,Articular cartilage in diarthrodial joints functions as a load-bearing tissue with a nearly frictionless surface. This unique characteristic is attributed to the composition of cartilage tissue where ,"[615.0, 1358.0, 1129.0, 1424.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,32,footnote,"E-mail address: M.DiasCastilho@umcutrecht.nl (M. Castilho). + $ ^{1} $Shared authorship.","[81.0, 1384.0, 454.0, 1423.0]",footnote,0.7,"[""footnote label: E-mail address: M.DiasCastilho@umcutrecht.nl (M. Castilho).\n""]",footnote,0.7,body_zone,body_like,none,True,True +1,33,footer,"https://doi.org/10.1016/j.matdes.2020.109025 + +0264-1275/© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/","[81.0, 1456.0, 1001.0, 1495.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,number,2,"[65.0, 74.0, 77.0, 89.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421.0, 72.0, 752.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,2,text,"(structural) components, type II collagen fibrils and glycosaminoglycans (GAGs), as well as cells, are hierarchically distributed throughout the tissue [1–3]. Damage to articular cartilage can cause p","[61.0, 111.0, 573.0, 404.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,Regenerative approaches based on biofabrication [10] technologies are a potential alternative to repair damaged articular cartilage tissue [11]. Advances in (micro) fibre formation and deposition tech,"[61.0, 404.0, 574.0, 823.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"It is known that the electrical field (EF), and its resulting electrical force, the main fibre pulling force in the MEW process, is affected by the collector design in both shape, dimension [24], and ","[61.0, 825.0, 574.0, 1345.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Therefore, in this study, we investigate how to translate the fabrication of fibre reinforced structures from flat to more anatomically relevant, non-flat surfaces with the convergence of MEW and extr","[60.0, 1346.0, 574.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"domes) and biomaterials, i.e. bioceramics, magnesium phosphate ce- +ment (MgP); thermoplastics, polycaprolactone (PCL); and hydrogels, +gelatin methacryloyl (gelMA), is studied (Fig. 1). Through computa","[596.0, 111.0, 1110.0, 301.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,2. Materials and methods 2.1. Materials,"[598.0, 320.0, 796.0, 383.0]",paper_title,0.6,"[""page-1 frontmatter title guard: 2. Materials and methods 2.1. Materials""]",paper_title,0.6,frontmatter_side_zone,support_like,heading_numbered,True,True +2,8,footer,,"[599.0, 362.0, 700.0, 383.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,9,text,"Gelatin methacryloyl (gelMA) was synthesized as previously described [36]. Briefly, gelatin (type A, derived from porcine skin, 175 Bloom, Sigma Aldrich) was dissolved at 10% w/v in phosphate-buffered","[596.0, 404.0, 1111.0, 888.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,2.2. Impedance spectroscopy measurements,"[598.0, 907.0, 904.0, 929.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Impedance spectroscopy measurements""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +2,11,text,"Dielectric properties of substrate materials were measured with an impedance/gain-phase analyser (1260 Impedance Analyser, Solartron Analytical) with a dielectric interface (1296A Dielectric Interface","[596.0, 949.0, 1110.0, 1181.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,display_formula, $$ \varepsilon_{r}=\frac{C}{C_{0}} $$ ,"[603.0, 1192.0, 665.0, 1234.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +2,13,formula_number,(1),"[1083.0, 1203.0, 1107.0, 1224.0]",non_body_insert,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,False +2,14,text,"where $ C_{0} $ is the capacity of the empty capacitor. In addition, electrical conductivity ( $ \sigma $) in siemens per metre was obtained indirectly by determining first the material resistance (R","[595.0, 1250.0, 1109.0, 1337.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,display_formula, $$ \sigma=\frac{l}{RA} $$ ,"[598.0, 1349.0, 659.0, 1389.0]",non_body_insert,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,False +2,16,formula_number,(2),"[1083.0, 1360.0, 1107.0, 1380.0]",non_body_insert,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,False +2,17,text,where l terms represent length and A the cross-sectional area of the measured material specimen.,"[596.0, 1404.0, 1109.0, 1449.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,Q.C. Peiffer et al / Materials and Design 195 (2020) 109025,"[439.0, 72.0, 769.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,3,"[1113.0, 73.0, 1126.0, 90.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,image,,"[182.0, 106.0, 1023.0, 244.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,image,,"[180.0, 241.0, 1026.0, 335.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,B.,"[187.0, 350.0, 203.0, 370.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,5,image,,"[186.0, 347.0, 1013.0, 593.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,C.,"[584.0, 350.0, 604.0, 370.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,7,figure_title,Fig. 1. Deposition of melt electrowritten (MEW) fibres on clinically relevant shapes and materials. A) Schematic representation of the different collecting geometries ranging from flat (with a thickne,"[79.0, 619.0, 1125.0, 691.0]",figure_caption,0.92,"[""figure_title label: Fig. 1. Deposition of melt electrowritten (MEW) fibres on cl""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,8,paragraph_title,2.3. Surface roughness measurements,"[81.0, 735.0, 342.0, 757.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Surface roughness measurements""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,9,text,"Surface roughness of substrate materials was measured using a surface roughness tester (SJ-400, Mitutoyo Corp.) as detailed in Supplementary Methods.","[80.0, 777.0, 590.0, 841.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,paragraph_title,2.4. Melt electrowriting (MEW),"[81.0, 876.0, 301.0, 898.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Melt electrowriting (MEW)""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,11,text,"MEW was performed with polycaprolactone (PCL, Purasorb PC12, Corbion) molten in a metallic cartridge at 80 °C with an air pressure of 110–125 kPa, 24G nozzle, voltage of 7–11 kV (3D Discovery Evolutio","[79.0, 917.0, 592.0, 1109.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,paragraph_title,2.5. Fibre evaluation,"[81.0, 1142.0, 226.0, 1163.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Fibre evaluation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,13,text,"Fibre morphology and fibre stacking was evaluated by scanning electronic microscopy (SEM) (Phenom Pro desktop, ThermoFischer Scientific) (Supplementary Fig. 2A). Samples were coated with 6 nm gold usi","[78.0, 1183.0, 591.0, 1312.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,paragraph_title,2.6. Printing accuracy quantification,"[81.0, 1346.0, 333.0, 1368.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Printing accuracy quantification""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,15,text,Fibre scaffolds were imaged with an upright microscope (Olympus BX430) and subsequently processed with Fiji (version 2.0.0-rc-54/1.51 h). A selection of pores in the central region of the scaffold wer,"[79.0, 1388.0, 590.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,16,paragraph_title,2.7. Finite element analysis,"[617.0, 735.0, 808.0, 756.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Finite element analysis""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,17,text,"Numerical simulation of the electric field strength and distribution were performed (COMSOL Multiphysics Simulation Software, Version 5.1 COMSOL Inc.). The MEW printhead and collecting substrate geome","[614.0, 777.0, 1129.0, 1093.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,18,paragraph_title,2.8. Fabrication and matrix formation of clinically relevant surfaces,"[616.0, 1114.0, 1080.0, 1136.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Fabrication and matrix formation of clinically relevant""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,19,text,"A polycaprolactone (PCL) dome structure was resurfaced with MEW fibres and gelatin methacryloyl (gelMA) hydrogel, encapsulated with articular cartilage progenitor cells (ACPCs). A screw driven extrusi","[614.0, 1156.0, 1128.0, 1388.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,20,paragraph_title,2.9. Cell culture,"[616.0, 1409.0, 730.0, 1430.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Cell culture""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,21,text,Equine derived articular cartilage-resident progenitor cells (ACPCs) were isolated from the metacarpophalangeal joints of skeletally mature,"[615.0, 1451.0, 1126.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,4,"[64.0, 74.0, 77.0, 88.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421.0, 72.0, 752.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +4,2,text,equine donors and expanded as previously described [38]. These donors have been donated to science by their owners and procedures were followed according to the guidelines of the Ethical and Animal We,"[61.0, 112.0, 574.0, 426.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,2.10. In vitro evaluation of (bio) fabricated implants,"[62.0, 446.0, 425.0, 468.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. In vitro evaluation of (bio) fabricated implants""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,4,text,"During culture, metabolic activity was measured using a resazurin assay (Sigma Aldrich) at day 1, 7, 14, 28. After 28 days, matrix formation was quantified by biochemical assessment of GAG (dimethylme","[62.0, 488.0, 574.0, 720.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,paragraph_title,2.11. Mechanical analysis of fibre reinforced gelMA scaffolds,"[62.0, 739.0, 478.0, 761.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.11. Mechanical analysis of fibre reinforced gelMA scaffold""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,6,text,"Uniaxial compression tests were performed on a universal testing machine (Zwick Z010, Germany) equipped with a 20 N load cell. Tests were conducted at a rate of 1 mm/min at room temperature, with all ","[61.0, 780.0, 574.0, 950.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,paragraph_title,2.12. Statistical analysis,"[63.0, 969.0, 232.0, 990.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.12. Statistical analysis""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,8,text,"Data is represented as mean ± standard deviation. For surface roughness measurements, impedance spectroscopy, fibre diameter measurements, scaffold thickness, pore ratio, and in vitro studies, at leas","[61.0, 1010.0, 573.0, 1286.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,3. Results 3.1. Material properties: Surface roughness and electrical conductive properties,"[62.0, 1304.0, 572.0, 1389.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results 3.1. Material properties: Surface roughness and e""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,10,footer,,"[62.0, 1346.0, 572.0, 1389.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,11,text,Magnesium phosphate (MgP) and gelMA substrates presented higher surface roughness values (R_a and R_q between 3.61 and 5.21 μm) than PCL and Aluminium substrates (R_a and R_q between 0.07 and 0.32 μm),"[61.0, 1409.0, 573.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,"confirmed the electrical conductivity and relative permittivity of PCL, +MgP, gelMA, and aluminium (Al) collecting substrates of 1 and 4 mm +(Table 1). PCL and MgP behaved as non-conductive materials wit","[596.0, 110.0, 1110.0, 260.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,paragraph_title,3.2. Effect of collecting material conductivity on fibre deposition,"[598.0, 280.0, 1038.0, 302.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Effect of collecting material conductivity on fibre dep""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,14,text,"The effect of the conductivity of the collecting materials on fibre deposition was studied using substrates with thicknesses of 1 and 4 mm (Fig. 2A, B). A significant smaller fibre diameter was observ","[596.0, 322.0, 1111.0, 740.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,15,text,"Scaffolds fabricated onto non-conductive materials (PCL, MgP) were ~50 $ \mu $m less high as compared to scaffolds fabricated onto conductive materials (gelMA, aluminium) (Fig. 2G, supplementary Fig.","[596.0, 740.0, 1110.0, 952.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,16,paragraph_title,"3.3. Effect of collector geometry on fibre deposition: non-flat, wedge and curved substrates","[597.0, 972.0, 1109.0, 1014.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Effect of collector geometry on fibre deposition: non-f""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,17,text,"Printing onto a 45° wedge substrates showed similar trends as printing onto dome-structures. In general, printing on wedge-shaped collecting materials without z-correction in the printing trajectory (","[596.0, 1034.0, 1110.0, 1245.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,18,figure_title,"Table 1 +Relative permittivity $ \varepsilon_{r} $ and electrical conductivity $ \sigma $ of investigated materials.","[597.0, 1289.0, 1067.0, 1327.0]",table_caption,0.9,"[""table prefix matched: Table 1\nRelative permittivity $ \\varepsilon_{r} $ and elect""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,19,table,"
Substrate biomaterialRelative permittivity ( $ \varepsilon_{r} $, at 1 Hz)Electrical conductivity ( $ \sigma $, S m $ ^{-1} $)
Polycaprolactone (PCL)<","[602.0, 1330.0, 1104.0, 1487.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,0,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[438.0, 72.0, 769.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +5,1,number,5,"[1113.0, 73.0, 1126.0, 90.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,figure_title,A.,"[158.0, 104.0, 185.0, 131.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,3,image,,"[158.0, 106.0, 601.0, 250.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,4,figure_title,B.,"[603.0, 106.0, 625.0, 130.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,5,image,,"[609.0, 102.0, 990.0, 245.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,figure_title,C.,"[154.0, 254.0, 182.0, 283.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,7,chart,,"[152.0, 292.0, 575.0, 591.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,figure_title,D.,"[603.0, 254.0, 632.0, 281.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,9,chart,,"[613.0, 282.0, 1039.0, 593.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,10,figure_title,E.,"[157.0, 596.0, 182.0, 624.0]",figure_inner_text,0.9,"[""panel label / figure inner text: E.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,11,image,,"[145.0, 629.0, 595.0, 742.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,12,figure_title,F.,"[618.0, 597.0, 640.0, 623.0]",figure_inner_text,0.9,"[""panel label / figure inner text: F.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,13,image,,"[147.0, 766.0, 594.0, 900.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,image,,"[613.0, 615.0, 1059.0, 889.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,15,figure_title,G.,"[154.0, 912.0, 184.0, 939.0]",figure_inner_text,0.9,"[""panel label / figure inner text: G.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,16,chart,,"[152.0, 939.0, 580.0, 1215.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,17,chart,,"[614.0, 911.0, 1026.0, 1218.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,18,figure_title,"Fig. 2. Fibre collection on flat-shaped collecting materials (PCL, MgP, gelMA, and Al). A, B) collecting materials of 1 mm and 4 mm high were investigated. C) Effect of collector velocity on fibre dia","[79.0, 1240.0, 1125.0, 1329.0]",figure_caption,0.92,"[""figure_title label: Fig. 2. Fibre collection on flat-shaped collecting materials""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,19,text,"These observations are slightly more pronounced for less conductive materials (PCL and MgP). Scaffolds fabricated (using z-trajectory correction) onto non-conductive wedges (PCL, MgP) were 100 to 200 ","[79.0, 1371.0, 591.0, 1479.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,20,text,"MgP wedges featured two-fold lower pore ratio than scaffolds fabri- +cated onto the gelMA wedge.","[614.0, 1372.0, 1125.0, 1414.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,21,text,"Z-correction in the printhead trajectory also improved the accuracy of fibre deposition when printing onto dome-structures (Fig. 3A, B). Computational simulation confirmed that the EF strength was con","[615.0, 1415.0, 1127.0, 1478.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,0,number,6,"[64.0, 74.0, 78.0, 90.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421.0, 72.0, 752.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +6,2,figure_title,A.,"[146.0, 107.0, 169.0, 131.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,3,figure_title,B.,"[639.0, 109.0, 658.0, 130.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,4,image,,"[142.0, 113.0, 999.0, 369.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,figure_title,C.,"[134.0, 387.0, 157.0, 410.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,6,figure_title,PO,"[279.0, 390.0, 308.0, 413.0]",figure_caption_candidate,0.85,"[""figure_title label: PO""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +6,7,image,,"[132.0, 388.0, 1040.0, 665.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,chart,,"[133.0, 675.0, 572.0, 960.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,figure_title,E.,"[580.0, 675.0, 601.0, 699.0]",figure_inner_text,0.9,"[""panel label / figure inner text: E.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,10,chart,,"[590.0, 667.0, 1028.0, 959.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,11,figure_title,"Fig. 3. Fibre collection on curved collecting materials (PCL, MgP, gelMA, and Al). A) Schematic representation of the evaluated printhead trajectories with and without z-correction. B) Representative ","[63.0, 983.0, 1107.0, 1072.0]",figure_caption,0.92,"[""figure_title label: Fig. 3. Fibre collection on curved collecting materials (PCL""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,12,text,"and normal to the curved surface when printing with z-correction in the printhead trajectory (Fig. 3C). Although scaffold thickness was relatively unaffected by the collecting material used, scaffold ","[61.0, 1115.0, 574.0, 1327.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,13,paragraph_title,3.4. Resurfacing the entire joint surface – Simple convex surfaces,"[63.0, 1346.0, 508.0, 1368.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Resurfacing the entire joint surface \u2013 Simple convex su""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,14,text,"A PCL scaffold, approximating the native curvature of an average human femur, was successfully resurfaced with a boxed-microfibre architecture and filled with a cell-laden gelMA hydrogel (Fig. 4A). Th","[61.0, 1388.0, 574.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,15,text,"in the compressive modulus as compared to hydrogel only and scaffold +only groups (Supplementary Fig. 5). During the 28 days of culture, the +fibre reinforced hydrogel on top of the femur structure retai","[595.0, 1114.0, 1111.0, 1306.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,16,paragraph_title,4. Discussion,"[598.0, 1325.0, 703.0, 1346.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,17,text,"This study demonstrates the challenges of translating the fabrication of microfibre reinforcing scaffolding structures from flat to curved, anatomically relevant geometries and clinically relevant mat","[596.0, 1367.0, 1110.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,0,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[438.0, 72.0, 769.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,1,number,7,"[1113.0, 73.0, 1126.0, 89.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,figure_title,A.,"[93.0, 108.0, 115.0, 129.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,3,figure_title,Chondrogenic part,"[713.0, 107.0, 847.0, 128.0]",figure_caption_candidate,0.85,"[""figure_title label: Chondrogenic part""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +7,4,image,,"[99.0, 125.0, 1093.0, 330.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,5,figure_title,B.,"[95.0, 331.0, 113.0, 351.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,6,image,,"[125.0, 341.0, 1101.0, 546.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,7,figure_title,C.,"[92.0, 549.0, 115.0, 572.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,8,figure_title,D.,"[458.0, 549.0, 480.0, 572.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,9,chart,,"[117.0, 562.0, 426.0, 798.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,10,figure_title,E.,"[94.0, 791.0, 114.0, 814.0]",figure_inner_text,0.9,"[""panel label / figure inner text: E.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,11,image,,"[468.0, 554.0, 1106.0, 1016.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,12,chart,,"[107.0, 811.0, 420.0, 1023.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,Fig. 4. Resurfacing a fully resorbable PCL mimicking contour of a human femoral condyle surface and cartilage-like tissue formation after 28 days of in vitro culture. A) Macroscopic cross section of M,"[79.0, 1045.0, 1125.0, 1116.0]",figure_caption,0.92,"[""figure_title label: Fig. 4. Resurfacing a fully resorbable PCL mimicking contour""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,14,text,"relevant material and anatomically relevant shapes was achieved. Furthermore, a converged printed, resurfaced human condyle-shaped construct was fabricated and supported cartilage-tissue formation aft","[79.0, 1160.0, 591.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,15,text,"It was shown that MEW fibre diameters are strongly affected by the materials they are printed on. Printing on conductive materials (gelMA, aluminium) resulted in larger fibre diameters as compared to ","[79.0, 1244.0, 591.0, 1455.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,16,text,"induced jet-lag. Interestingly, fibre diameter was not affected by the +thickness of the collecting materials used, which confirmed that electri- +cal conductive properties are not significantly affected b","[613.0, 1159.0, 1128.0, 1456.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,number,8,"[65.0, 74.0, 78.0, 89.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421.0, 72.0, 752.0, 91.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +8,2,text,only small differences in the EF strength magnitude were determined when using PCL and MgP as collecting materials in comparison to the more conductive collecting materials.,"[61.0, 112.0, 573.0, 173.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,"Interestingly, accurate fibre deposition on non-flat, i.e. wedge- and curve-shaped, collecting materials was significantly improved when the distance between the printhead and the collecting substrate","[61.0, 175.0, 574.0, 445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"Although we have shown that accurate deposition of MEW fibres is possible on different collecting materials and on anatomically relevant geometries, some deposition inaccuracies were still observed. I","[61.0, 446.0, 574.0, 844.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"As a potential application to treat full-thickness cartilage or osteochondral defects, we demonstrated the fabrication of structures with a fibre-reinforced osteochondral construct that anatomically r","[61.0, 844.0, 574.0, 1307.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +8,6,paragraph_title,5. Conclusion,"[63.0, 1325.0, 171.0, 1346.0]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusion""]",section_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +8,7,text,"on less conductive materials, including bioceramics and thermoplasts. Accurate fibre deposition on non-flat geometries (wedge- and curved-shape structures) was shown to be successful, yet, maintaining","[596.0, 111.0, 1110.0, 363.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"Taken together, this study demonstrates the printing of well-organized microfibre scaffolds on clinically relevant collecting materials with non-flat geometries. The electrical properties of the subst","[61.0, 1367.0, 574.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +8,9,text,"Supplementary data to this article can be found online at https://doi. +org/10.1016/j.matdes.2020.109025.","[596.0, 364.0, 1108.0, 405.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,paragraph_title,Funding sources,"[599.0, 431.0, 730.0, 452.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Funding sources""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,11,text,"This research was supported by EU funded—E11312 BioArchitect project together with regenHU, the Dutch Arthritis Foundation (LLP-12), and the European Research Council (ERC) consolidator grant 3D-JOINT","[596.0, 472.0, 1110.0, 641.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,paragraph_title,Authors contributions,"[598.0, 666.0, 773.0, 687.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Authors contributions""]",subsection_heading,0.6,body_zone,body_like,none,True,True +8,13,text,"Conceived and designed the experiment: MC, MdR, QCP, JvD. Collected the data: MdR, QCP.","[622.0, 708.0, 1064.0, 749.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,14,text,"Contributed data or analysis tools: MdR, QCP, MC, JvD, ED, DC. +Performed analysis: MdR, QCP, MC, ED, DC.","[622.0, 751.0, 1071.0, 798.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,text,"Wrote the manuscript: MC, MdR, QCP, JM.","[623.0, 792.0, 931.0, 814.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,16,paragraph_title,Declaration of Competing Interest,"[598.0, 838.0, 862.0, 859.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Declaration of Competing Interest""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True +8,17,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[597.0, 879.0, 1109.0, 945.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,18,paragraph_title,Acknowledgments,"[599.0, 964.0, 746.0, 985.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,19,text,"The authors gratefully thank Jacopo Bani, Alexandre Ribeiro and Michael Kuster for their help with the experimental part of this manuscript. In addition, the authors are very grateful to Marco Viveen ","[596.0, 1004.0, 1111.0, 1236.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,20,paragraph_title,References,"[600.0, 1257.0, 688.0, 1278.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +8,21,reference_content,"[1] J Alice S.F., B. Asheesh, A.R. Scoot, The Basic Science of Articular Cartilage: Sports Health, 1, 2009 461–468.","[607.0, 1293.0, 1108.0, 1325.0]",reference_item,0.85,"[""reference content label: [1] J Alice S.F., B. Asheesh, A.R. Scoot, The Basic Science ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,22,reference_content,"[2] I.A.D. Mancini, L. Rieppo, B. Pouran, I.O. Afara, F.M.S. 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Introduction", + "found_in_fulltext": true, + "fulltext_offset": 2114 + }, + { + "block_id": "p1:30", + "page": 1, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "* Corresponding author at: Department of Orthopaedics, University Medical Center", + "found_in_fulltext": true, + "fulltext_offset": 2130 + }, + { + "block_id": "p1:31", + "page": 1, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Articular cartilage in diarthrodial joints functions as a load-bearing tissue wi", + "found_in_fulltext": true, + "fulltext_offset": 2270 + }, + { + "block_id": "p1:32", + "page": 1, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "E-mail address: M.DiasCastilho@umcutrecht.nl (M. 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Impedance spectroscopy measurements", + "found_in_fulltext": true, + "fulltext_offset": 9566 + }, + { + "block_id": "p2:11", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Dielectric properties of substrate materials were measured with an impedance/gai", + "found_in_fulltext": true, + "fulltext_offset": 9607 + }, + { + "block_id": "p2:12", + "page": 2, + "role": "unknown_structural", + "zone": "body_zone", + "render_default": false, + "snippet": "$$ \\varepsilon_{r}=\\frac{C}{C_{0}} $$", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:13", + "page": 2, + "role": "non_body_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "(1)", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p2:14", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "where $ C_{0} $ is the capacity of the empty capacitor. 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Resurfacing the entire joint surface – Simple convex surfaces", + "found_in_fulltext": true, + "fulltext_offset": 21976 + }, + { + "block_id": "p6:14", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "A PCL scaffold, approximating the native curvature of an average human femur, wa", + "found_in_fulltext": true, + "fulltext_offset": 22043 + }, + { + "block_id": "p6:15", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "in the compressive modulus as compared to hydrogel only and scaffold only groups", + "found_in_fulltext": true, + "fulltext_offset": 22389 + }, + { + "block_id": "p6:16", + "page": 6, + "role": "section_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "4. Discussion", + "found_in_fulltext": true, + "fulltext_offset": 23599 + }, + { + "block_id": "p6:17", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This study demonstrates the challenges of translating the fabrication of microfi", + "found_in_fulltext": true, + "fulltext_offset": 23613 + }, + { + "block_id": "p7:0", + "page": 7, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:1", + "page": 7, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "7", + "found_in_fulltext": true, + "fulltext_offset": 3018 + }, + { + "block_id": "p7:3", + "page": 7, + "role": "figure_caption_candidate", + "zone": "body_zone", + "render_default": false, + "snippet": "Chondrogenic part", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p7:14", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "relevant material and anatomically relevant shapes was achieved. Furthermore, a ", + "found_in_fulltext": true, + "fulltext_offset": 24079 + }, + { + "block_id": "p7:15", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "It was shown that MEW fibre diameters are strongly affected by the materials the", + "found_in_fulltext": true, + "fulltext_offset": 24311 + }, + { + "block_id": "p7:16", + "page": 7, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "induced jet-lag. Interestingly, fibre diameter was not affected by the thickness ", + "found_in_fulltext": true, + "fulltext_offset": 25964 + }, + { + "block_id": "p8:0", + "page": 8, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "8", + "found_in_fulltext": true, + "fulltext_offset": 1852 + }, + { + "block_id": "p8:1", + "page": 8, + "role": "noise", + "zone": "", + "render_default": false, + "snippet": "Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:2", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "only small differences in the EF strength magnitude were determined when using P", + "found_in_fulltext": true, + "fulltext_offset": 26984 + }, + { + "block_id": "p8:3", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Interestingly, accurate fibre deposition on non-flat, i.e. wedge- and curve-shap", + "found_in_fulltext": true, + "fulltext_offset": 27158 + }, + { + "block_id": "p8:4", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Although we have shown that accurate deposition of MEW fibres is possible on dif", + "found_in_fulltext": true, + "fulltext_offset": 28008 + }, + { + "block_id": "p8:5", + "page": 8, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "As a potential application to treat full-thickness cartilage or osteochondral de", + "found_in_fulltext": true, + "fulltext_offset": 29265 + }, + { + "block_id": "p8:6", + "page": 8, + "role": "section_heading", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "5. Conclusion", + "found_in_fulltext": true, + "fulltext_offset": 30769 + }, + { + "block_id": "p8:7", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "on less conductive materials, including bioceramics and thermoplasts. Accurate f", + "found_in_fulltext": true, + "fulltext_offset": 30783 + }, + { + "block_id": "p8:8", + "page": 8, + "role": "body_paragraph", + "zone": "", + "render_default": true, + "snippet": "Taken together, this study demonstrates the printing of well-organized microfibr", + "found_in_fulltext": true, + "fulltext_offset": 31613 + }, + { + "block_id": "p8:9", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Supplementary data to this article can be found online at https://doi. org/10.10", + "found_in_fulltext": true, + "fulltext_offset": 32134 + }, + { + "block_id": "p8:10", + "page": 8, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Funding sources", + "found_in_fulltext": true, + "fulltext_offset": 32241 + }, + { + "block_id": "p8:11", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This research was supported by EU funded—E11312 BioArchitect project together wi", + "found_in_fulltext": true, + "fulltext_offset": 32259 + }, + { + "block_id": "p8:12", + "page": 8, + "role": "subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Authors contributions", + "found_in_fulltext": true, + "fulltext_offset": 32728 + }, + { + "block_id": "p8:13", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Conceived and designed the experiment: MC, MdR, QCP, JvD. Collected the data: Md", + "found_in_fulltext": true, + "fulltext_offset": 32750 + }, + { + "block_id": "p8:14", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Contributed data or analysis tools: MdR, QCP, MC, JvD, ED, DC. Performed analysi", + "found_in_fulltext": true, + "fulltext_offset": 32838 + }, + { + "block_id": "p8:15", + "page": 8, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Wrote the manuscript: MC, MdR, QCP, JM.", + "found_in_fulltext": true, + "fulltext_offset": 32943 + }, + { + "block_id": "p8:16", + "page": 8, + "role": "backmatter_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Declaration of Competing Interest", + "found_in_fulltext": true, + "fulltext_offset": 32985 + }, + { + "block_id": "p8:17", + "page": 8, + "role": "backmatter_body", + "zone": "body_zone", + "render_default": true, + "snippet": "The authors declare that they have no known competing financial interests or per", + "found_in_fulltext": true, + "fulltext_offset": 33021 + }, + { + "block_id": "p8:18", + "page": 8, + "role": "sub_subsection_heading", + "zone": "body_zone", + "render_default": true, + "snippet": "Acknowledgments", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:19", + "page": 8, + "role": "backmatter_body", + "zone": "body_zone", + "render_default": true, + "snippet": "The authors gratefully thank Jacopo Bani, Alexandre Ribeiro and Michael Kuster f", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p8:20", + "page": 8, + "role": "reference_heading", + "zone": "reference_zone", + "render_default": true, + "snippet": "References", + "found_in_fulltext": true, + "fulltext_offset": 33195 + }, + { + "block_id": "p8:21", + "page": 8, + "role": "reference_item", + "zone": "reference_zone", + "render_default": true, + "snippet": "[1] J Alice S.F., B. 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"reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:26", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:27", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:28", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:29", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:30", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:31", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:32", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + }, + { + "block_id": "p9:33", + "page": 9, + "role": "reference_item", + "zone": "reference_zone", + "reason": "logical_order_between_reference_members" + } + ] + } +} \ No newline at end of file diff --git a/audit/KZP6FB4Y/audit_report.json b/audit/KZP6FB4Y/audit_report.json index a1f49cfc..faabf5dc 100644 --- a/audit/KZP6FB4Y/audit_report.json +++ b/audit/KZP6FB4Y/audit_report.json @@ -5,45 +5,45 @@ "focus": [], "artifact_fingerprint": { "result_json_hash": "sha256:e18f86f94e91f2741effab8d4d90a0367a1397ef6c6b933dc1a7fe4eb1f3e37f", - "meta_json_hash": "sha256:61e637e629cc01232e8f5213bbf28bf6318a5de6dbcac26a8d575c4dc17f4adc", - "blocks_raw_hash": "sha256:1ffd8e6be4a4890b4ed0aff330656a9fea79fd479f27b9e7b6f6622217fda204", - "structured_blocks_hash": 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"table_inventory_hash": "sha256:758833de03a2665769208c8cdc29f14cfe984d7f4c0a97407afffb103418a90e", + "reader_figures_hash": "sha256:2a64ccda2c5387d02505dbaf4122af4e73fb766fb6c9f55f6c24a50d7ab74e94", "resolved_metadata_hash": "sha256:05d03a507c6666e06a358d7ffbc105ccdfee95378eada62523317c3d016db1c7", - "fulltext_hash": "sha256:54e9463eb01d7100fe27a7b8c8694e156293cc23cb3aefa141963aa6a1530b31", - "block_trace_hash": "sha256:85774736cb5e3cb0c611807e659769c98ec71bc769a0a0cae7b569d2dfeb3eb5", + "fulltext_hash": "sha256:a712908773206b213a63951511dc7e88710bbedee92359fbebd273fd1e0bfdf7", + "block_trace_hash": "sha256:4e698a8edc50e6b5ab48b7604ee418f6e94ae22d765335cfeabac300e4d10154", "annotated_pages": { - "page_001.png": "sha256:1edc91eab79172734239355aac81d66a38788bdd87cd073c5f9fb82278f93f78", - "page_002.png": "sha256:1f7f155887665bd5b4b21fa420ae4279b9511e0643ce113f9cf2611df0031d71", - "page_003.png": "sha256:c9c59ae8344da347ae31e8e1608976aba15727f93b8779f5f4997c0e5e075af0", + "page_001.png": 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"sha256:755578d7baa858884da547b645f2013ab664ef1b79a3ae2ae9402e136f45d6db", + "page_022.png": "sha256:a5f453da9d225b8ca132f5b308eefc6301a9fb8b314eb8ba870042a938924fc0", + "page_023.png": "sha256:0eae437d97029eba333c99e0c124f6f7a5097320e6da03286dcd4b31203c9fd7", + "page_024.png": "sha256:5ea3d991f4e4a66c7fcb39f561ca98120885f5516efa6fbc1b5e9d2d1106e68d", + "page_025.png": "sha256:f4988894915b2423f990aa2ac787adfc6768b0d365059d9ec1c2151c8c12233d", "page_026.png": "sha256:2c8f28e3854fd7ba51a56609823cb80d25f12a9e3d0f0a44b66114799dead5ca", - "page_027.png": "sha256:f5c8e9f84b12a7dcea317e1e9d9d82ea870759ef35a9ccca8c230a85ec2726b9", - "page_028.png": "sha256:a232fa0883597f6b55e13394627787cacc9e8d00e1b300ede2bb58df1f260c8e", + "page_027.png": "sha256:ed22098f029e2ddbf9e05a0e7baa866f653cb6753a1bda7c392edd0a60323833", + "page_028.png": "sha256:6480325574ef3d35d4dd0b090229b3c6547b2b6bfb1024d7dc4275b05ca68b0f", "page_029.png": "sha256:8a92ec3cc02493f57f3e35fb28dcc8de998a80f24eb89935e16a40d1b53868e8", "page_030.png": "sha256:c1faf3305e503215201af4a327267b0cdffbc784c2babf6b5169481737a1e437", "page_031.png": "sha256:bef44e8b238c262011a16f8a42a4a8ffb08d96e5fadd6ae1de6bd989cce28090", @@ -113,7 +113,6 @@ 20, 23, 25, - 26, 27, 28 ], @@ -330,19 +329,6 @@ "p25:5", "p25:6", "p25:7", - "p26:0", - "p26:1", - "p26:2", - "p26:3", - "p26:4", - "p26:5", - "p26:6", - "p26:7", - "p26:8", - "p26:9", - "p26:10", - "p26:11", - "p26:12", "p27:0", "p27:1", "p27:2", @@ -691,18 +677,6 @@ "artifact": "reference_span_audit.json" } }, - { - "category": "frontmatter_error", - "severity": "major", - "block_ids": [], - "truth": "page 1 should have clearer frontmatter role resolution", - "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", - "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", - "evidence": { - "annotated_page": "annotated_pages/page_001.png", - "artifact": "page_risk_summary.json" - } - }, { "category": "same_page_boundary_error", "severity": "major", @@ -715,23 +689,10 @@ "artifact": "page_risk_summary.json" } }, - { - "category": "object_ownership_error", - "severity": "major", - "block_ids": [], - "truth": "figure/table ownership should map captions and assets coherently", - "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", - "root_cause_hypothesis": "caption-to-asset grouping ambiguity", - "evidence": { - "annotated_page": null, - "artifact": "figure_table_ownership_summary.json" - } - }, { "category": "render_mapping_error", "severity": "minor", "block_ids": [ - "p1:1", "p1:2", "p1:3", "p1:5", @@ -742,15 +703,16 @@ "p1:13", "p1:14", "p1:15", + "p1:17", "p1:28", "p2:0", - "p2:1", "p3:0", - "p3:1", + "p3:6", "p3:7", "p4:0", - "p4:1", - "p5:0" + "p4:7", + "p5:0", + "p5:6" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/KZP6FB4Y/audit_report.md b/audit/KZP6FB4Y/audit_report.md index b3374be8..9bc5f266 100644 --- a/audit/KZP6FB4Y/audit_report.md +++ b/audit/KZP6FB4Y/audit_report.md @@ -2,8 +2,8 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [1, 2, 3, 7, 8, 11, 12, 13, 14, 15, 17, 18, 20, 23, 25, 26, 27, 28] -- Reviewed blocks: 291 +- Reviewed pages: [1, 2, 3, 7, 8, 11, 12, 13, 14, 15, 17, 18, 20, 23, 25, 27, 28] +- Reviewed blocks: 278 ## Findings @@ -27,9 +27,7 @@ - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals -- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output ## Disposition Guidance diff --git a/audit/KZP6FB4Y/audit_scope.json b/audit/KZP6FB4Y/audit_scope.json index da9aeb3f..981fe192 100644 --- a/audit/KZP6FB4Y/audit_scope.json +++ b/audit/KZP6FB4Y/audit_scope.json @@ -16,7 +16,6 @@ 20, 23, 25, - 26, 27, 28 ], @@ -50,37 +49,27 @@ "p1:26", "p1:27", "p1:28", - "p2:4", "p2:6", - "p3:5", "p3:7", - "p7:6", "p7:7", "p7:8", "p7:10", "p8:2", "p8:3", "p8:4", - "p8:8", "p11:3", "p11:5", "p11:7", "p11:9", "p12:2", - "p12:6", - "p13:4", "p13:6", "p14:3", - "p14:5", "p14:12", - "p15:3", "p15:7", "p15:11", - "p17:4", "p17:7", "p17:9", "p17:11", - "p18:5", "p18:7", "p18:9", "p18:11", @@ -88,7 +77,6 @@ "p18:15", "p20:2", "p20:3", - "p20:5", "p20:6", "p20:7", "p20:8", @@ -99,54 +87,15 @@ "p20:14", "p20:15", "p20:16", - "p23:4", "p23:8", "p23:10", "p23:13", "p23:14", "p23:16", "p23:17", - "p25:0", - "p25:1", "p25:2", "p25:3", - "p25:4", - "p25:5", - "p25:6", - "p25:7", - "p26:0", - "p26:1", - "p26:2", - "p26:3", - "p26:4", - "p26:5", - "p26:6", - "p26:7", - "p26:8", - "p26:9", - "p26:10", - "p26:11", - "p26:12", - "p27:0", - "p27:1", - "p27:2", - "p27:3", - "p27:4", - "p27:5", - "p27:6", "p27:7", - "p27:8", - "p27:9", - "p27:10", - "p27:11", - "p27:12", - "p27:13", - "p27:14", - "p27:15", - "p27:16", - "p27:17", - "p27:18", - "p28:2", "p28:4", "p28:5", "p28:6", @@ -301,8 +250,7 @@ "block_id": "p1:7", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -514,8 +462,7 @@ "block_id": "p1:21", "page": 1, "required_reason": [ - "frontmatter", - "needs_resolution" + "frontmatter" ], "minimum_fields": [ "block_id", @@ -631,21 +578,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p2:4", - "page": 2, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p2:6", "page": 2, @@ -661,21 +593,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p3:5", - "page": 3, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p3:7", "page": 3, @@ -691,21 +608,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p7:6", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:7", "page": 7, @@ -796,21 +698,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p8:8", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:3", "page": 11, @@ -886,36 +773,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p12:6", - "page": 12, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p13:4", - "page": 13, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p13:6", "page": 13, @@ -946,21 +803,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p14:5", - "page": 14, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p14:12", "page": 14, @@ -976,21 +818,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p15:3", - "page": 15, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p15:7", "page": 15, @@ -1021,21 +848,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p17:4", - "page": 17, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p17:7", "page": 17, @@ -1081,21 +893,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p18:5", - "page": 18, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p18:7", "page": 18, @@ -1201,21 +998,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p20:5", - "page": 20, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p20:6", "page": 20, @@ -1366,21 +1148,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p23:4", - "page": 23, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p23:8", "page": 23, @@ -1471,41 +1238,10 @@ "truth_reference_membership" ] }, - { - "block_id": "p25:0", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:1", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p25:2", "page": 25, "required_reason": [ - "backmatter", "object_ownership" ], "minimum_fields": [ @@ -1532,373 +1268,10 @@ "truth_reference_membership" ] }, - { - "block_id": "p25:4", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:5", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:6", - "page": 25, - "required_reason": [ - "backmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p25:7", - "page": 25, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:0", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:1", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:2", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:3", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:4", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:5", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:6", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:7", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:8", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:9", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:10", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:11", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p26:12", - "page": 26, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:0", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:1", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:2", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:3", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:4", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:5", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:6", - "page": 27, - "required_reason": [ - "backmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p27:7", "page": 27, "required_reason": [ - "backmatter", "object_ownership" ], "minimum_fields": [ @@ -1910,186 +1283,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p27:8", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:9", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:10", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:11", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:12", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:13", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:14", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:15", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:16", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:17", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p27:18", - "page": 27, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p28:2", - "page": 28, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p28:4", "page": 28, @@ -2109,8 +1302,7 @@ "block_id": "p28:5", "page": 28, "required_reason": [ - "backmatter", - "needs_resolution" + "reference_span" ], "minimum_fields": [ "block_id", @@ -2746,22 +1938,22 @@ { "page": 2, "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 3, "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 7, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 3 }, { "page": 8, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 3 }, { "page": 11, @@ -2771,62 +1963,57 @@ { "page": 12, "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 13, "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 14, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 2 }, { "page": 15, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 2 }, { "page": 17, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 3 }, { "page": 18, "must_review_page": true, - "required_block_count": 6 + "required_block_count": 5 }, { "page": 20, "must_review_page": true, - "required_block_count": 13 + "required_block_count": 12 }, { "page": 23, "must_review_page": true, - "required_block_count": 7 + "required_block_count": 6 }, { "page": 25, "must_review_page": true, - "required_block_count": 8 - }, - { - "page": 26, - "must_review_page": true, - "required_block_count": 13 + "required_block_count": 2 }, { "page": 27, "must_review_page": true, - "required_block_count": 19 + "required_block_count": 1 }, { "page": 28, "must_review_page": true, - "required_block_count": 44 + "required_block_count": 43 } ] } \ No newline at end of file diff --git a/audit/KZP6FB4Y/block_coverage_summary.json b/audit/KZP6FB4Y/block_coverage_summary.json index 5a917ed4..a3446b8c 100644 --- a/audit/KZP6FB4Y/block_coverage_summary.json +++ b/audit/KZP6FB4Y/block_coverage_summary.json @@ -218,7 +218,7 @@ "block_id": "p1:7", "page": 1, "raw_label": "doc_title", - "role": "unknown_structural", + "role": "paper_title", "zone": "frontmatter_main_zone", "bbox": [ 71.0, @@ -438,7 +438,7 @@ "block_id": "p1:18", "page": 1, "raw_label": "abstract", - "role": "abstract_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 397.0, @@ -498,7 +498,7 @@ "block_id": "p1:21", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -738,7 +738,7 @@ "block_id": "p2:4", "page": 2, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -938,7 +938,7 @@ "block_id": "p3:5", "page": 3, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -978,7 +978,7 @@ "block_id": "p3:7", "page": 3, "raw_label": "table", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 155.0, @@ -1478,7 +1478,7 @@ "block_id": "p5:8", "page": 5, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 607.0, @@ -1778,7 +1778,7 @@ "block_id": "p6:9", "page": 6, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -1998,7 +1998,7 @@ "block_id": "p7:6", "page": 7, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -2298,7 +2298,7 @@ "block_id": "p8:8", "page": 8, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -2518,7 +2518,7 @@ "block_id": "p9:8", "page": 9, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -2778,7 +2778,7 @@ "block_id": "p10:8", "page": 10, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 607.0, @@ -3298,7 +3298,7 @@ "block_id": "p12:6", "page": 12, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -3458,7 +3458,7 @@ "block_id": "p13:4", "page": 13, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -3658,7 +3658,7 @@ "block_id": "p14:5", "page": 14, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -3918,7 +3918,7 @@ "block_id": "p15:3", "page": 15, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -4258,7 +4258,7 @@ "block_id": "p16:5", "page": 16, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 607.0, @@ -4438,7 +4438,7 @@ "block_id": "p17:4", "page": 17, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -4738,7 +4738,7 @@ "block_id": "p18:5", "page": 18, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -5118,7 +5118,7 @@ "block_id": "p19:6", "page": 19, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -5318,7 +5318,7 @@ "block_id": "p20:5", "page": 20, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 607.0, @@ -5778,7 +5778,7 @@ "block_id": "p21:9", "page": 21, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -6158,7 +6158,7 @@ "block_id": "p22:10", "page": 22, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -6418,7 +6418,7 @@ "block_id": "p23:4", "page": 23, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -6938,7 +6938,7 @@ "block_id": "p24:10", "page": 24, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 607.0, @@ -7099,7 +7099,7 @@ "page": 25, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 71.0, 70.0, @@ -7119,7 +7119,7 @@ "page": 25, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 933.0, 70.0, @@ -7139,7 +7139,7 @@ "page": 25, "raw_label": "image", "role": "figure_asset", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 244.0, 110.0, @@ -7179,7 +7179,7 @@ "page": 25, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 68.0, 1064.0, @@ -7199,7 +7199,7 @@ "page": 25, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 69.0, 1336.0, @@ -7218,8 +7218,8 @@ "block_id": "p25:6", "page": 25, "raw_label": "text", - "role": "unknown_structural", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 606.0, 1063.0, @@ -7239,7 +7239,7 @@ "page": 25, "raw_label": "number", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 586.0, 1513.0, @@ -7259,7 +7259,7 @@ "page": 26, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 71.0, 70.0, @@ -7279,7 +7279,7 @@ "page": 26, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 933.0, 70.0, @@ -7299,7 +7299,7 @@ "page": 26, "raw_label": "paragraph_title", "role": "subsection_heading", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 71.0, 107.0, @@ -7319,7 +7319,7 @@ "page": 26, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 68.0, 129.0, @@ -7339,7 +7339,7 @@ "page": 26, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 68.0, 400.0, @@ -7359,7 +7359,7 @@ "page": 26, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 68.0, 1070.0, @@ -7379,7 +7379,7 @@ "page": 26, "raw_label": "paragraph_title", "role": "subsection_heading", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 609.0, 108.0, @@ -7399,7 +7399,7 @@ "page": 26, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 606.0, 130.0, @@ -7419,7 +7419,7 @@ "page": 26, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 607.0, 672.0, @@ -7439,7 +7439,7 @@ "page": 26, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 606.0, 945.0, @@ -7459,7 +7459,7 @@ "page": 26, "raw_label": "paragraph_title", "role": "section_heading", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 609.0, 1301.0, @@ -7479,7 +7479,7 @@ "page": 26, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 605.0, 1343.0, @@ -7499,7 +7499,7 @@ "page": 26, "raw_label": "number", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 586.0, 1514.0, @@ -7519,7 +7519,7 @@ "page": 27, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 71.0, 70.0, @@ -7539,7 +7539,7 @@ "page": 27, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 933.0, 70.0, @@ -7559,7 +7559,7 @@ "page": 27, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 68.0, 106.0, @@ -7579,7 +7579,7 @@ "page": 27, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 68.0, 462.0, @@ -7599,7 +7599,7 @@ "page": 27, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 69.0, 1110.0, @@ -7619,7 +7619,7 @@ "page": 27, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 68.0, 1300.0, @@ -7638,8 +7638,8 @@ "block_id": "p27:6", "page": 27, "raw_label": "figure_title", - "role": "table_caption_candidate", - "zone": "tail_nonref_hold_zone", + "role": "table_caption", + "zone": "display_zone", "bbox": [ 607.0, 107.0, @@ -7659,7 +7659,7 @@ "page": 27, "raw_label": "table", "role": "table_html", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 613.0, 168.0, @@ -7679,7 +7679,7 @@ "page": 27, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 607.0, 628.0, @@ -7699,7 +7699,7 @@ "page": 27, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 606.0, 671.0, @@ -7718,8 +7718,8 @@ "block_id": "p27:10", "page": 27, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "tail_nonref_hold_zone", + "role": "subsection_heading", + "zone": "body_zone", "bbox": [ 608.0, 881.0, @@ -7738,8 +7738,8 @@ "block_id": "p27:11", "page": 27, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 607.0, 921.0, @@ -7759,7 +7759,7 @@ "page": 27, "raw_label": "paragraph_title", "role": "subsection_heading", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 608.0, 1027.0, @@ -7778,8 +7778,8 @@ "block_id": "p27:13", "page": 27, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 608.0, 1069.0, @@ -7798,8 +7798,8 @@ "block_id": "p27:14", "page": 27, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 608.0, 1132.0, @@ -7818,8 +7818,8 @@ "block_id": "p27:15", "page": 27, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 606.0, 1173.0, @@ -7838,8 +7838,8 @@ "block_id": "p27:16", "page": 27, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "tail_nonref_hold_zone", + "role": "sub_subsection_heading", + "zone": "body_zone", "bbox": [ 609.0, 1257.0, @@ -7858,8 +7858,8 @@ "block_id": "p27:17", "page": 27, "raw_label": "text", - "role": "backmatter_body", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 606.0, 1299.0, @@ -7879,7 +7879,7 @@ "page": 27, "raw_label": "number", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 586.0, 1513.0, @@ -7938,7 +7938,7 @@ "block_id": "p28:2", "page": 28, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 71.0, @@ -7998,8 +7998,8 @@ "block_id": "p28:5", "page": 28, "raw_label": "reference_content", - "role": "unknown_structural", - "zone": "tail_nonref_hold_zone", + "role": "reference_item", + "zone": "reference_zone", "bbox": [ 90.0, 230.0, @@ -8359,7 +8359,7 @@ "page": 28, "raw_label": "reference_content", "role": "reference_item", - "zone": "reference_zone", + "zone": "", "bbox": [ 619.0, 108.0, diff --git a/audit/KZP6FB4Y/block_trace.csv b/audit/KZP6FB4Y/block_trace.csv index 0a09eca9..afb3150f 100644 --- a/audit/KZP6FB4Y/block_trace.csv +++ b/audit/KZP6FB4Y/block_trace.csv @@ -6,7 +6,7 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,4,header,Biomaterials,"[517.0, 170.0, 678.0, 200.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False 1,5,header,journal homepage: www.elsevier.com/locate/biomaterials,"[375.0, 233.0, 818.0, 256.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,6,header_image,,"[1000.0, 108.0, 1116.0, 254.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False -1,7,doc_title,Force-electric biomaterials and devices for regenerative medicine,"[71.0, 330.0, 863.0, 362.0]",unknown_structural,0.6,"[""page-1 frontmatter title guard: Force-electric biomaterials and devices for regenerative med""]",paper_title,0.6,frontmatter_main_zone,support_like,none,False,True +1,7,doc_title,Force-electric biomaterials and devices for regenerative medicine,"[71.0, 330.0, 863.0, 362.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Force-electric biomaterials and devices for regenerative med""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True 1,8,image,,"[1001.0, 297.0, 1059.0, 353.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True 1,9,text,"Shuncheng Yao $ ^{a,b,1} $, Xi Cui $ ^{b,d,1} $, Chao Zhang $ ^{d,*} $, Wenguo Cui $ ^{a,**} $, Zhou Li $ ^{b,c,***} $ $ ^{ID} $","[70.0, 382.0, 695.0, 435.0]",authors,0.8,"[""page-1 zone author_zone: Shuncheng Yao $ ^{a,b,1} $, Xi Cui $ ^{b,d,1} $, Chao Zhang ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,10,text," $ ^{a} $ Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruiin Hospital, Shanghai Jia","[71.0, 449.0, 969.0, 478.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $ Department of Orthopaedics, Shanghai Key Laboratory""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True @@ -22,10 +22,12 @@ Triboelectric Electroactive Regenerative medicine","[71.0, 621.0, 220.0, 726.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords:\nForce-electric conversion\nPiezoelectric\nTriboelect""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False 1,17,paragraph_title,A B S T R A C T,"[400.0, 583.0, 522.0, 602.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: A B S T R A C T""]",section_heading,0.5,body_zone,body_like,short_fragment,True,True -1,18,abstract,"There is a growing recognition that force-electric conversion biomaterials and devices can convert mechanical energy into electrical energy without an external power source, thus potentially revolutio","[397.0, 622.0, 1120.0, 873.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,18,abstract,"There is a growing recognition that force-electric conversion biomaterials and devices can convert mechanical energy into electrical energy without an external power source, thus potentially revolutio","[397.0, 622.0, 1120.0, 873.0]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True 1,19,paragraph_title,1. Introduction,"[72.0, 931.0, 198.0, 951.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True 1,20,text,"As human society continues to develop, human concern for their own health is increasing. However, the rapid ageing of the population, unhealthy diets and the occurrence of accidents have placed a heav","[69.0, 973.0, 582.0, 1226.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -1,21,text,,"[606.0, 931.0, 1119.0, 1226.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +1,21,text,"medicine. The generation of bioelectricity is related to the segregation of +biofilm formation as well as the distribution and flow of ions on both +sides of these membranes, and the resulting bioelectr","[606.0, 931.0, 1119.0, 1226.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,22,footnote,This article is part of a special issue entitled: Regenerative Bioelectronics published in Biomaterials.,"[77.0, 1264.0, 728.0, 1283.0]",footnote,0.7,"[""footnote label: This article is part of a special issue entitled: Regenerati""]",footnote,0.7,body_zone,body_like,none,True,True 1,23,footnote,* Corresponding author.,"[80.0, 1285.0, 249.0, 1304.0]",footnote,0.7,"[""footnote label: * Corresponding author.""]",footnote,0.7,body_zone,body_like,none,True,True 1,24,footnote,*** Corresponding author.,"[81.0, 1304.0, 254.0, 1322.0]",footnote,0.7,"[""footnote label: *** Corresponding author.""]",footnote,0.7,body_zone,body_like,none,True,True @@ -43,7 +45,9 @@ Available online 24 March 2025 2,1,header,Biomaterials 320 (2025) 123288,"[932.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False 2,2,text,"infections, which limit the further development of electrical stimulation in the field of regenerative medicine.","[68.0, 107.0, 581.0, 149.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,3,text,"The human body generates a large amount of biomechanical energy during physical activity, cardiopulmonary exercise, and blood circulation. In addition, the introduction of external stimuli such as ult","[68.0, 148.0, 583.0, 739.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,4,text,,"[606.0, 107.0, 1121.0, 273.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,4,text,"the implantable microsystems based on TENG to drive the long-term +operation of implantable medical devices in vivo [29]. However, the +weak and uncertain nature of the ambient mechanical forces results","[606.0, 107.0, 1121.0, 273.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,5,text,This review paper aims to overview various applications of force-electric biomaterials and devices based on piezoelectric and triboelectric effects in the field of regenerative medicine (Fig. 1). In o,"[605.0, 273.0, 1122.0, 737.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,6,image,,"[251.0, 774.0, 934.0, 1443.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 2,7,figure_title,Fig. 1. Force-electric biomaterials and devices for regenerative medicine under different force-driven modes.,"[237.0, 1468.0, 950.0, 1489.0]",figure_caption,0.92,"[""figure_title label: Fig. 1. Force-electric biomaterials and devices for regenera""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True @@ -53,9 +57,11 @@ Available online 24 March 2025 3,2,text,"of diseases. Finally, challenges and opportunities in the application of force-electric biomaterials and devices in the field of regenerative medicine are overviewed.","[68.0, 106.0, 582.0, 170.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,3,paragraph_title,2. Piezoelectric biomaterials based on force-electric conversion,"[70.0, 190.0, 568.0, 210.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Piezoelectric biomaterials based on force-electric conver""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True 3,4,text,"In 1880, the Curie brothers revealed the piezoelectric effect in piezoelectric materials for the first time in their published paper [30], which laid the fundamental working principle of piezoelectric","[67.0, 232.0, 583.0, 589.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,5,text,,"[606.0, 106.0, 1120.0, 336.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +3,5,text,"direction, this design mode is referred to as the d33 mode; if the potential +is perpendicular to the direction of applied stress/strain (i.e., the 1-di­ +rection), it is termed the d31 mode. Additional","[606.0, 106.0, 1120.0, 336.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,6,text,"Piezoelectric materials are a direct manifestation of the force-electric conversion effect and are crucial components in many modern devices, such as sonar [33], medical US [34], sensors, actuators [3","[606.0, 337.0, 1121.0, 589.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,7,table,"
i)ii)
i)ii)
TypeApplicationForce-driven modeElectrical propertiesStimulation timeRef.
Piezoelectric biomaterialsRe","[74.0, 146.0, 1117.0, 512.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 20,4,text,"recovery and regulation of organ functions such as the brain, heart, eyes, and muscles; and thirdly, electrical stimulation therapy for specific diseases, utilizing electric field effects to achieve p","[70.0, 542.0, 582.0, 607.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -20,5,text,,"[607.0, 542.0, 1120.0, 606.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +20,5,text,"electric field-catalyzed therapy, and electrical stimulation to eliminate +diseased cells, thus providing new methods and strategies for tissue +function recovery and regeneration.","[607.0, 542.0, 1120.0, 606.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 20,6,figure_title,Tissue regeneration,"[194.0, 664.0, 413.0, 691.0]",figure_caption_candidate,0.85,"[""figure_title label: Tissue regeneration""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False 20,7,image,,"[155.0, 709.0, 446.0, 840.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 20,8,image,,"[156.0, 846.0, 448.0, 952.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True @@ -295,7 +331,9 @@ Available online 24 March 2025 21,6,text,"It is worth noting that, in designing electrical stimulation neural conduit scaffolds, besides meeting the requirements of electrical stimulation, the structural design of the scaffold is equally cruc","[68.0, 861.0, 581.0, 1050.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,7,paragraph_title,5.1.2. Bone,"[71.0, 1070.0, 163.0, 1088.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1.2. Bone""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 21,8,text,"Bone tissue stands as the largest natural piezoelectric material in organisms, with its piezoelectricity originating from the oriented arrangement of collagen fibers. The surface of injured bone tissu","[69.0, 1090.0, 582.0, 1490.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -21,9,text,,"[606.0, 107.0, 1120.0, 314.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +21,9,text,"femur within 6 weeks. Compared to direct electrical stimulation, direct +contact of the newly formed tissue with the material can more effec­ +tively amplify the electrical signals [212]. Cui et al. fab","[606.0, 107.0, 1120.0, 314.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,10,text,"Similarly, the growth process of cartilage resembles that of bone cells, and cartilage regeneration poses a crucial challenge in osteoarthritis and cartilage defects. In promoting the regeneration of ","[607.0, 317.0, 1120.0, 566.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,11,text,Tendon disorders also represent a key challenge in the field of orthopedics. Studies have shown that devices based on piezoelectric conversion can regulate ion channels in tendon cells in vitro and mo,"[606.0, 566.0, 1120.0, 819.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,12,paragraph_title,5.1.3. Skin,"[610.0, 840.0, 697.0, 858.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1.3. Skin""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True @@ -314,7 +352,9 @@ Available online 24 March 2025 22,7,text,"Brain electrical stimulation (BES), a pioneering therapeutic and interventional approach in neurology, has been proven to influence neurotransmitter release and synaptic plasticity [220]. The underlyi","[69.0, 695.0, 582.0, 1030.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,8,text,"In terms of technological innovations, Zhao et al. reported a wearable neuromodulation stimulator that does not require an external battery, capable of modulating synaptic plasticity in both long-term","[69.0, 1030.0, 582.0, 1343.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,9,text,"It is worth noting that BES may exhibit different time frames in improving symptoms of various neurological diseases. For example, tremor and rigidity may respond immediately, while long-term issues s","[69.0, 1343.0, 582.0, 1490.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -22,10,text,,"[606.0, 107.0, 1120.0, 295.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +22,10,text,"reactions caused by lead migration, including motor disorders, speech +impairments, cognitive difficulties, and emotional fluctuations. There­ +fore, the implementation of BES therapy requires strict pa","[606.0, 107.0, 1120.0, 295.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,11,paragraph_title,5.2.2. Heart,"[610.0, 316.0, 707.0, 335.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2.2. Heart""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 22,12,text,The application of force-electrically convertible materials in cardiac disease treatment primarily focuses on two major areas: cardiac pacemakers and myocardial patches (as shown in Fig. 12G and H). S,"[607.0, 338.0, 1120.0, 609.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,13,text,"As early as 1963, Parsonnet et al. pioneered an attempt to capture in vivo mechanical energy from the pulsatile expansion of the aorta through an implanted piezoelectric device [231]. In Chapter 2 of ","[607.0, 610.0, 1120.0, 838.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -327,7 +367,9 @@ Available online 24 March 2025 23,1,header,Biomaterials 320 (2025) 123288,"[933.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 23,2,text,"smooth muscle. Skeletal muscle is responsible for bodily activities, cardiac muscle controls heart contraction specifically, while smooth muscle is widely distributed in blood vessels and the digestiv","[67.0, 107.0, 581.0, 170.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,3,text,"When muscle tissue is injured, its regenerative capacity becomes particularly significant. In contrast to skin wound healing, muscle regeneration refers specifically to the repair process of damaged m","[68.0, 169.0, 584.0, 527.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -23,4,text,,"[605.0, 107.0, 1120.0, 210.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +23,4,text,"role of motor neurons in the physiological environment, influencing +muscle cell proliferation rates and hypertrophy characteristics. For +instance, the addition of electrical stimulation to two-dimensi","[605.0, 107.0, 1120.0, 210.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,5,text,"In vitro cultures have also revealed various materials with beneficial effects on the adhesion and proliferation of myoblasts, as well as their myogenic differentiation. For example, negatively charge","[605.0, 211.0, 1121.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,6,text,"Furthermore, Fang et al. prepared piezoelectric elastomer using a copolymerization method of bio-based diacids and diols (Fig. 12I). This material has an elastic modulus matching that of skeletal musc","[606.0, 463.0, 1121.0, 527.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,7,figure_title,A),"[88.0, 579.0, 120.0, 608.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True @@ -353,7 +395,9 @@ Available online 24 March 2025 24,7,text,"The vagus nerve, as a composite of motor and sensory fibers, has extensive connections with various body systems. Electrical stimulation of the vagus nerve is an effective means of regulating neural a","[68.0, 903.0, 582.0, 1299.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,8,text,"In the field of pain relief, Yin et al. developed an US-driven electrical stimulant for blocking cancer-induced bone pain (CIBP) $ [244] $. They utilized BTO nanosheets to achieve single-cell-level e","[68.0, 1300.0, 581.0, 1425.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,9,text,"Recently, the construction of electrically sensitive functional cells and the regulation of cell secretion function through electrical stimulation have become research hotspots. Zhao et al. utilized p","[68.0, 1425.0, 582.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -24,10,text,,"[607.0, 106.0, 1120.0, 399.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +24,10,text,"PVDF films to generate suitable electrical stimulation to stimulate +electrically sensitive cells derived from the pancreatic β-cell line 1.1E7 +[245]. These cells were designed to express insulin, as w","[607.0, 106.0, 1120.0, 399.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,11,text,"In summary, the application of electromechanical conversion materials in the medical field demonstrates broad prospects and potential. From retinal electrical stimulation to artificial cochleas, from ","[607.0, 400.0, 1120.0, 631.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,12,paragraph_title,5.3. Disease treatment,"[609.0, 652.0, 773.0, 672.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3. Disease treatment""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 24,13,text,"In recent years, the disease treatment based on tissue regeneration has received increasing attention, and electrical stimulation has been studied to some extent as one of the strategies for disease t","[606.0, 694.0, 1120.0, 968.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -361,53 +405,56 @@ Available online 24 March 2025 24,15,text,"Drug delivery systems have become a hot research topic in the biomedical field, driven by the huge clinical demand for targeted therapies, in the hope of bringing more survival benefits to patients. R","[606.0, 1009.0, 1120.0, 1385.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,16,text,"In stimuli-responsive drug delivery systems, biopolymers, NPs, microneedles, and liposomes are used as common drug carriers that can be electrically stimulated and controlled by electroactive material","[606.0, 1385.0, 1121.0, 1490.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,17,number,24,"[586.0, 1514.0, 606.0, 1528.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -25,0,header,S. Yao et al.,"[71.0, 70.0, 145.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -25,1,header,Biomaterials 320 (2025) 123288,"[933.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -25,2,image,,"[244.0, 110.0, 940.0, 851.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,0,header,S. Yao et al.,"[71.0, 70.0, 145.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,1,header,Biomaterials 320 (2025) 123288,"[933.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +25,2,image,,"[244.0, 110.0, 940.0, 851.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 25,3,figure_title,Fig. 14. Electroactive materials and devices for disease treatment. A) Working mechanism of the F-MN device composed of F-TENG and dissolving MN patch. Reproduced with permission from Ref. [252]. Copy,"[66.0, 866.0, 1121.0, 1041.0]",figure_caption,0.92,"[""figure_title label: Fig. 14. Electroactive materials and devices for disease tre""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True -25,4,text,"controlled drug release. Based on this, Wang et al. proposed a wearable, self-powered MN patch, which was integrated with a flexible friction nanogenerator (F-TENG), aiming at deep tumor therapy $ [2","[68.0, 1064.0, 581.0, 1336.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -25,5,text,"In vitro transdermal drug delivery based on electroactive materials and devices mainly relies on electroporation, electrophoresis, and iontophoresis, which impose limitations on drug delivery efficien","[69.0, 1336.0, 582.0, 1484.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -25,6,text,,"[606.0, 1063.0, 1121.0, 1464.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True -25,7,number,25,"[586.0, 1513.0, 606.0, 1528.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -26,0,header,S. Yao et al.,"[71.0, 70.0, 145.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -26,1,header,Biomaterials 320 (2025) 123288,"[933.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -26,2,paragraph_title,5.3.2. Catalytic therapy,"[71.0, 107.0, 245.0, 127.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3.2. Catalytic therapy""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True -26,3,text,"In the last decade, nanocatalysts designed for localized generation of ROS have been considered as a promising strategy for disease treatment to overcome drug resistance and reduce side effects. Howev","[68.0, 129.0, 582.0, 400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -26,4,text,"In the process of enhancing the catalytic performance of electroactive materials, electric field stimulation can effectively regulate the electron mobility, electron polarization structure and electro","[68.0, 400.0, 582.0, 1071.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -26,5,text,"Piezoelectric biomaterials can directly convert mechanical pressure into an electrical response when stimulated by US, thus creating a large dynamic built-in electric field [262,263]. Under the action","[68.0, 1070.0, 582.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -26,6,paragraph_title,5.3.3. Electrotherapy,"[609.0, 108.0, 764.0, 127.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3.3. Electrotherapy""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True -26,7,text,The use of electrical stimulation in the treatment of disease stems from the discovery of the existence of an endogenous electric field in organisms. This electric field is important in embryonic deve,"[606.0, 130.0, 1120.0, 672.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -26,8,text,"In addition, Zulmari et al. used piezoelectric $ [P(VDF-TrFE)] $ microparticles (MPs) to induce IRE in 4T1 breast cancer cells and thereby kill the cells $ [251] $. Under US stimulation, MPs located","[607.0, 672.0, 1119.0, 944.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -26,9,text,"Electrical stimulation can not only directly induce tumor cell death, but also recruit immune cells for cancer immunotherapy. Li et al. prepared a fabric DC-TENG consisting of eight repetitively woven","[606.0, 945.0, 1120.0, 1280.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -26,10,paragraph_title,6. Conclusions and future perspectives,"[609.0, 1301.0, 918.0, 1322.0]",section_heading,0.85,"[""paragraph_title label with numbering: 6. Conclusions and future perspectives""]",section_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True -26,11,text,"In the field of biomedical science, biomaterials and electro-stimulation devices based on force-electric conversion, including PENGs and TENGs, are emerging as novel electrostimulation methods that do","[605.0, 1343.0, 1121.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -26,12,number,26,"[586.0, 1514.0, 606.0, 1528.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -27,0,header,S. Yao et al.,"[71.0, 70.0, 145.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -27,1,header,Biomaterials 320 (2025) 123288,"[933.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -27,2,text,"From the perspective of materials, optimizing the performance of force-electrically convertible materials is crucial for future advancements. Material selection must comprehensively consider factors s","[68.0, 106.0, 583.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -27,3,text,"In terms of device design, integrating suitable materials into a complete device is a topic that requires in-depth research. This involves structural design, encapsulation strategies, integration, and","[68.0, 462.0, 582.0, 1112.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -27,4,text,"Despite the advantages of battery-free and sustainable electro-stimulation methods based on force-electricity conversion, the instability and uncontrollability of their tiny mechanical energy conversi","[69.0, 1110.0, 582.0, 1299.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -27,5,text,"Moreover, not only the application of force-electric materials in biomedicine but also the entire field of electrostimulation therapy in biomedicine relies on the advancement of basic biological mecha","[68.0, 1300.0, 582.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +25,4,text,"controlled drug release. Based on this, Wang et al. proposed a wearable, self-powered MN patch, which was integrated with a flexible friction nanogenerator (F-TENG), aiming at deep tumor therapy $ [2","[68.0, 1064.0, 581.0, 1336.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,5,text,"In vitro transdermal drug delivery based on electroactive materials and devices mainly relies on electroporation, electrophoresis, and iontophoresis, which impose limitations on drug delivery efficien","[69.0, 1336.0, 582.0, 1484.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,6,text,"the TENG output up to 70 V [253]. RBCs loaded with DOX were used as +an antitumor drug delivery system (DDS). After loading DOX, the +erythrocyte membrane was very stable with little DOX release. How­ +e","[606.0, 1063.0, 1121.0, 1464.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,7,number,25,"[586.0, 1513.0, 606.0, 1528.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,0,header,S. Yao et al.,"[71.0, 70.0, 145.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,1,header,Biomaterials 320 (2025) 123288,"[933.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +26,2,paragraph_title,5.3.2. Catalytic therapy,"[71.0, 107.0, 245.0, 127.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3.2. Catalytic therapy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +26,3,text,"In the last decade, nanocatalysts designed for localized generation of ROS have been considered as a promising strategy for disease treatment to overcome drug resistance and reduce side effects. Howev","[68.0, 129.0, 582.0, 400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,4,text,"In the process of enhancing the catalytic performance of electroactive materials, electric field stimulation can effectively regulate the electron mobility, electron polarization structure and electro","[68.0, 400.0, 582.0, 1071.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,5,text,"Piezoelectric biomaterials can directly convert mechanical pressure into an electrical response when stimulated by US, thus creating a large dynamic built-in electric field [262,263]. Under the action","[68.0, 1070.0, 582.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,6,paragraph_title,5.3.3. Electrotherapy,"[609.0, 108.0, 764.0, 127.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3.3. Electrotherapy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +26,7,text,The use of electrical stimulation in the treatment of disease stems from the discovery of the existence of an endogenous electric field in organisms. This electric field is important in embryonic deve,"[606.0, 130.0, 1120.0, 672.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,8,text,"In addition, Zulmari et al. used piezoelectric $ [P(VDF-TrFE)] $ microparticles (MPs) to induce IRE in 4T1 breast cancer cells and thereby kill the cells $ [251] $. Under US stimulation, MPs located","[607.0, 672.0, 1119.0, 944.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,9,text,"Electrical stimulation can not only directly induce tumor cell death, but also recruit immune cells for cancer immunotherapy. Li et al. prepared a fabric DC-TENG consisting of eight repetitively woven","[606.0, 945.0, 1120.0, 1280.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,10,paragraph_title,6. Conclusions and future perspectives,"[609.0, 1301.0, 918.0, 1322.0]",section_heading,0.85,"[""paragraph_title label with numbering: 6. Conclusions and future perspectives""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +26,11,text,"In the field of biomedical science, biomaterials and electro-stimulation devices based on force-electric conversion, including PENGs and TENGs, are emerging as novel electrostimulation methods that do","[605.0, 1343.0, 1121.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,12,number,26,"[586.0, 1514.0, 606.0, 1528.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +27,0,header,S. Yao et al.,"[71.0, 70.0, 145.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +27,1,header,Biomaterials 320 (2025) 123288,"[933.0, 70.0, 1120.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +27,2,text,"From the perspective of materials, optimizing the performance of force-electrically convertible materials is crucial for future advancements. Material selection must comprehensively consider factors s","[68.0, 106.0, 583.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,3,text,"In terms of device design, integrating suitable materials into a complete device is a topic that requires in-depth research. This involves structural design, encapsulation strategies, integration, and","[68.0, 462.0, 582.0, 1112.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,4,text,"Despite the advantages of battery-free and sustainable electro-stimulation methods based on force-electricity conversion, the instability and uncontrollability of their tiny mechanical energy conversi","[69.0, 1110.0, 582.0, 1299.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,5,text,"Moreover, not only the application of force-electric materials in biomedicine but also the entire field of electrostimulation therapy in biomedicine relies on the advancement of basic biological mecha","[68.0, 1300.0, 582.0, 1489.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 27,6,figure_title,"Table 2 -Potential risks and clinical translational challenges of force-electric biomaterials and devices.","[607.0, 107.0, 1118.0, 166.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 2\nPotential risks and clinical translational challenge""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True -27,7,table,"
TypePotential risksClinical translation challenges
Piezoelectric materialPiezoelectric ceramicsChronic inflamma","[613.0, 168.0, 1117.0, 598.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True -27,8,text,for the further optimization and application of electrostimulation therapy.,"[607.0, 628.0, 1118.0, 670.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -27,9,text,"In summary, electrostimulation devices based on force-electric conversion have broad application prospects in the biomedical field. However, to achieve their true clinical application and commercializ","[606.0, 671.0, 1120.0, 861.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -27,10,paragraph_title,CRediT authorship contribution statement,"[608.0, 881.0, 942.0, 902.0]",backmatter_heading,0.8,"[""backmatter heading on page 27: CRediT authorship contribution statement""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,unknown_like,none,True,True -27,11,text,"Shuncheng Yao: Writing – original draft, Conceptualization. Xi Cui: Writing – original draft, Conceptualization. Chao Zhang: Supervision. Wenguo Cui: Supervision. Zhou Li: Writing – review & editing, ","[607.0, 921.0, 1119.0, 1007.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -27,12,paragraph_title,Ethics approval and consent to participate,"[608.0, 1027.0, 942.0, 1049.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Ethics approval and consent to participate""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -27,13,text,This review article does not require any ethical approval or allied consent for publication.,"[608.0, 1069.0, 1118.0, 1111.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -27,14,paragraph_title,Declaration of competing interest,"[608.0, 1132.0, 875.0, 1153.0]",backmatter_heading,0.8,"[""backmatter heading on page 27: Declaration of competing interest""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,unknown_like,none,True,True -27,15,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[606.0, 1173.0, 1119.0, 1237.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -27,16,paragraph_title,Acknowledgments,"[609.0, 1257.0, 756.0, 1278.0]",backmatter_heading,0.8,"[""backmatter heading on page 27: Acknowledgments""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,unknown_like,short_fragment,True,True -27,17,text,"S.Y. and X.C. contributed equally to this work. This work was supported by the National Key R&D project from Minister of Science and Technology, China (2022YFB3804700), Beijing Natural Science Foundat","[606.0, 1299.0, 1120.0, 1447.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -27,18,number,27,"[586.0, 1513.0, 606.0, 1528.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +Potential risks and clinical translational challenges of force-electric biomaterials and devices.","[607.0, 107.0, 1118.0, 166.0]",table_caption,0.9,"[""table prefix matched: Table 2\nPotential risks and clinical translational challenge""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +27,7,table,"
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Piezoelectric materialPiezoelectric ceramicsChronic inflamma","[613.0, 168.0, 1117.0, 598.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +27,8,text,for the further optimization and application of electrostimulation therapy.,"[607.0, 628.0, 1118.0, 670.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,9,text,"In summary, electrostimulation devices based on force-electric conversion have broad application prospects in the biomedical field. However, to achieve their true clinical application and commercializ","[606.0, 671.0, 1120.0, 861.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,10,paragraph_title,CRediT authorship contribution statement,"[608.0, 881.0, 942.0, 902.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: CRediT authorship contribution statement""]",subsection_heading,0.6,body_zone,body_like,none,True,True +27,11,text,"Shuncheng Yao: Writing – original draft, Conceptualization. Xi Cui: Writing – original draft, Conceptualization. Chao Zhang: Supervision. Wenguo Cui: Supervision. Zhou Li: Writing – review & editing, ","[607.0, 921.0, 1119.0, 1007.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,12,paragraph_title,Ethics approval and consent to participate,"[608.0, 1027.0, 942.0, 1049.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Ethics approval and consent to participate""]",subsection_heading,0.6,body_zone,body_like,none,True,True +27,13,text,This review article does not require any ethical approval or allied consent for publication.,"[608.0, 1069.0, 1118.0, 1111.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,14,paragraph_title,Declaration of competing interest,"[608.0, 1132.0, 875.0, 1153.0]",body_paragraph,0.5,"[""backmatter boundary candidate: Declaration of competing interest""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True +27,15,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[606.0, 1173.0, 1119.0, 1237.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,16,paragraph_title,Acknowledgments,"[609.0, 1257.0, 756.0, 1278.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +27,17,text,"S.Y. and X.C. contributed equally to this work. This work was supported by the National Key R&D project from Minister of Science and Technology, China (2022YFB3804700), Beijing Natural Science Foundat","[606.0, 1299.0, 1120.0, 1447.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,18,number,27,"[586.0, 1513.0, 606.0, 1528.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 28,0,header,S. Yao et al.,"[71.0, 70.0, 144.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 28,1,header,Biomaterials 320 (2025) 123288,"[933.0, 71.0, 1120.0, 86.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -28,2,paragraph_title,Data availability,"[71.0, 107.0, 204.0, 127.0]",backmatter_heading,0.8,"[""backmatter heading on page 28: Data availability""]",backmatter_heading_candidate,0.8,body_zone,body_like,short_fragment,True,True +28,2,paragraph_title,Data availability,"[71.0, 107.0, 204.0, 127.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data availability""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True 28,3,text,No data was used for the research described in the article.,"[93.0, 150.0, 513.0, 169.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 28,4,paragraph_title,References,"[71.0, 190.0, 161.0, 209.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True -28,5,reference_content,". Cwynarski, G. Iacoboni, E. Tholouli, T. Menne, D.A. Irvine,","[90.0, 230.0, 474.0, 245.0]",unknown_structural,0.85,"[""reference content label: . Cwynarski, G. Iacoboni, E. Tholouli, T. Menne, D.A. Irvine""]",reference_item,0.85,tail_nonref_hold_zone,unknown_like,none,False,True +28,5,reference_content,". Cwynarski, G. Iacoboni, E. Tholouli, T. Menne, D.A. Irvine,","[90.0, 230.0, 474.0, 245.0]",reference_item,0.85,"[""reference content label: . Cwynarski, G. Iacoboni, E. Tholouli, T. Menne, D.A. Irvine""]",reference_item,0.85,reference_zone,unknown_like,none,True,True 28,6,reference_content,"N. Balasubramaniam, L. Wood, J. Shang, E. Xue, Y. Zhang, S. Basilico, M. Neves, M. Raymond, I. Scott, M. El-Kholy, R. Jha, H. Dainton-Smith, R. Hussain, W. Day, M. Ferrari, S. Thomas, K. Lilova, W. Br","[91.0, 240.0, 575.0, 340.0]",reference_item,0.85,"[""reference content label: N. Balasubramaniam, L. Wood, J. Shang, E. Xue, Y. Zhang, S. ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True 28,7,reference_content,"[2] J. Garcia, J. Daniels, Y. Lee, I. Zhu, K. Cheng, Q. Liu, D. Goodman, C. Burnett, C. Law, C. Thienpont, J. Alavi, C. Azimi, G. Montgomery, K.T. Roybal, J. Choi, Naturally occurring T cell mutations","[90.0, 342.0, 570.0, 405.0]",reference_item,0.85,"[""reference content label: [2] J. Garcia, J. Daniels, Y. Lee, I. Zhu, K. Cheng, Q. Liu,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 28,8,reference_content,"[3] A.H. Isaac, S.Y. Recalde Phillips, E. Ruben, M. Estes, V. Rajavel, T. Baig, C. Paleti, K. Landsgaard, R.H. Lee, T. Guda, M.F. Criscitiello, C. Gregory, D.L. Alge, Impact of PEG sensitization on th","[90.0, 407.0, 576.0, 468.0]",reference_item,0.85,"[""reference content label: [3] A.H. Isaac, S.Y. Recalde Phillips, E. Ruben, M. Estes, V""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True @@ -425,7 +472,7 @@ Potential risks and clinical translational challenges of force-electric biomater 28,20,reference_content,"[15] F. Qi, Y. Wang, T. Ma, S. Zhu, W. Zeng, X. Hu, Z. Liu, J. Huang, Z. Luo, Electrical regulation of olfactory ensheathing cells using conductive polypyrrole/chitosan polymers, Biomaterials 34 (2013","[82.0, 1268.0, 574.0, 1328.0]",reference_item,0.85,"[""reference content label: [15] F. Qi, Y. Wang, T. Ma, S. Zhu, W. Zeng, X. Hu, Z. Liu, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 28,21,reference_content,"[16] X. Ju, J. Kong, G. Qi, S. Hou, X. Diao, S. Dong, Y. Jin, A wearable electrostimulation-augmented ionic-gel photothermal patch doped with MXene for skin tumor treatment, Nat. Commun. 15 (2024), ht","[81.0, 1330.0, 568.0, 1391.0]",reference_item,0.85,"[""reference content label: [16] X. Ju, J. Kong, G. Qi, S. Hou, X. Diao, S. Dong, Y. Jin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 28,22,reference_content,"[17] S. Zhong, Z. Zhang, Q. Zhao, Z. Yue, C. Xiong, G. Chen, J. Wang, L. Li, Lattice expansion in ruthenium nanozymes improves catalytic activity and electroresponsiveness for boosting cancer therapy,","[81.0, 1395.0, 567.0, 1458.0]",reference_item,0.85,"[""reference content label: [17] S. Zhong, Z. Zhang, Q. Zhao, Z. Yue, C. Xiong, G. Chen,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True -28,23,reference_content,"[18] Z. Li, D. He, B. Guo, Z. Wang, H. Yu, Y. Wang, S. Jin, M. Yu, L. Zhu, L. Chen, C. Ding, X. Wu, T. Wu, S. Gong, J. Mao, Y. Zhou, D. Luo, Y. Liu, Self-promoted electroactive biomimetic mineralized ","[619.0, 108.0, 1109.0, 184.0]",reference_item,0.85,"[""reference content label: [18] Z. Li, D. He, B. Guo, Z. Wang, H. Yu, Y. Wang, S. Jin, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +28,23,reference_content,"[18] Z. Li, D. He, B. Guo, Z. Wang, H. Yu, Y. Wang, S. Jin, M. Yu, L. Zhu, L. Chen, C. Ding, X. Wu, T. Wu, S. Gong, J. Mao, Y. Zhou, D. Luo, Y. Liu, Self-promoted electroactive biomimetic mineralized ","[619.0, 108.0, 1109.0, 184.0]",reference_item,0.85,"[""reference content label: [18] Z. Li, D. He, B. Guo, Z. Wang, H. Yu, Y. Wang, S. Jin, ""]",reference_item,0.85,,reference_like,reference_numeric_bracket,True,True 28,24,reference_content,"[19] W. Liu, H. Zhao, C. Zhang, S. Xu, F. Zhang, L. Wei, F. Zhu, Y. Chen, Y. Chen, Y. Huang, M. Xu, Y. He, B.C. Heng, J. Zhang, Y. Shen, X. Zhang, H. Huang, L. Chen, X. Deng, In situ activation of fle","[617.0, 187.0, 1113.0, 264.0]",reference_item,0.85,"[""reference content label: [19] W. Liu, H. Zhao, C. Zhang, S. Xu, F. Zhang, L. Wei, F. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 28,25,reference_content,"[20] S. Bairagi, I. Shahid ul, C. Kumar, A. Babu, A.K. Aliyana, G. Stylios, S.C. Pillai, D. M. Mulvihill, Wearable nanocomposite textile-based piezoelectric and triboelectric nanogenerators: progress ","[619.0, 267.0, 1112.0, 330.0]",reference_item,0.85,"[""reference content label: [20] S. Bairagi, I. Shahid ul, C. Kumar, A. Babu, A.K. Aliya""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True 28,26,reference_content,"[21] W. Deng, Y. Zhou, A. Libanori, G. Chen, W. Yang, J. Chen, Piezoelectric nanogenerators for personalized healthcare, Chem. Soc. Rev. 51 (2022) 3380–3435, https://doi.org/10.1039/d1cs00858g.","[620.0, 332.0, 1068.0, 377.0]",reference_item,0.85,"[""reference content label: [21] W. Deng, Y. Zhou, A. Libanori, G. Chen, W. Yang, J. Che""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True diff --git a/audit/KZP6FB4Y/figure_table_ownership_summary.json b/audit/KZP6FB4Y/figure_table_ownership_summary.json index 71661dfc..f8e7559c 100644 --- a/audit/KZP6FB4Y/figure_table_ownership_summary.json +++ b/audit/KZP6FB4Y/figure_table_ownership_summary.json @@ -1,7 +1,7 @@ { "figures": { - "matched_count": 13, - "ambiguous_count": 2, + "matched_count": 14, + "ambiguous_count": 0, "unresolved_cluster_count": 0, "unmatched_asset_count": 1, "matched": [ @@ -14,6 +14,15 @@ "page": 2, "match_type": null }, + { + "figure_number": 2, + "legend_block_id": 8, + "asset_block_ids": [ + 7 + ], + "page": 3, + "match_type": null + }, { "figure_number": 3, "legend_block_id": 11, @@ -147,29 +156,22 @@ "match_type": null } ], - "ambiguous": [ - { - "figure_number": 2, - "legend_block_id": 8, - "asset_block_ids": [], - "candidate_asset_ids": [], - "page": 3 - }, - { - "figure_number": null, - "legend_block_id": 2, - "asset_block_ids": [], - "candidate_asset_ids": [], - "page": 20 - } - ], + "ambiguous": [], "unresolved": [] }, "tables": { - "matched_count": 0, + "matched_count": 1, "ambiguous_count": 0, "unmatched_asset_count": 2, - "matched": [], + "matched": [ + { + "table_number": 2, + "caption_block_id": 6, + "asset_block_ids": [], + "page": 27, + "match_status": "matched" + } + ], "ambiguous": [] } } \ No newline at end of file diff --git a/audit/KZP6FB4Y/fulltext_block_mapping_summary.json b/audit/KZP6FB4Y/fulltext_block_mapping_summary.json index 4ab90dd7..cc841ba4 100644 --- a/audit/KZP6FB4Y/fulltext_block_mapping_summary.json +++ b/audit/KZP6FB4Y/fulltext_block_mapping_summary.json @@ -1,7 +1,7 @@ { - "mappable_block_count": 575, - "found_count": 489, - "missing_count": 86, + "mappable_block_count": 601, + "found_count": 507, + "missing_count": 94, "rows": [ { "block_id": "p1:1", @@ -10,8 +10,8 @@ "zone": "frontmatter_main_zone", "render_default": false, "snippet": "Biomaterials 320 (2025) 123288", - "found_in_fulltext": false, - "fulltext_offset": -1 + "found_in_fulltext": true, + "fulltext_offset": 34132 }, { "block_id": "p1:2", @@ -56,9 +56,9 @@ { "block_id": "p1:7", "page": 1, - "role": "unknown_structural", + "role": "paper_title", "zone": "frontmatter_main_zone", - "render_default": false, + "render_default": true, "snippet": "Force-electric biomaterials and devices for regenerative medicine", "found_in_fulltext": true, "fulltext_offset": 2 @@ -140,8 +140,18 @@ "zone": "body_zone", "render_default": true, "snippet": "A B S T R A C T", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p1:18", + "page": 1, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "There is a growing recognition that force-electric conversion biomaterials and d", "found_in_fulltext": true, - "fulltext_offset": 1722 + "fulltext_offset": 283 }, { "block_id": "p1:19", @@ -151,7 +161,7 @@ "render_default": true, "snippet": "1. 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Finally, challenges and opportunities in the application of force-e", "found_in_fulltext": true, - "fulltext_offset": 8181 + "fulltext_offset": 9716 }, { "block_id": "p3:3", @@ -321,7 +351,7 @@ "render_default": true, "snippet": "2. Piezoelectric biomaterials based on force-electric conversion", "found_in_fulltext": true, - "fulltext_offset": 8351 + "fulltext_offset": 9886 }, { "block_id": "p3:4", @@ -331,7 +361,17 @@ "render_default": true, "snippet": "In 1880, the Curie brothers revealed the piezoelectric effect in piezoelectric m", "found_in_fulltext": true, - "fulltext_offset": 8416 + "fulltext_offset": 9951 + }, + { + "block_id": "p3:5", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "direction, this design mode is referred to as the d33 mode; if the potential is ", + "found_in_fulltext": true, + "fulltext_offset": 11174 }, { "block_id": "p3:6", @@ -340,13 +380,13 @@ "zone": "body_zone", "render_default": true, "snippet": "Piezoelectric materials are a direct manifestation of the force-electric convers", - "found_in_fulltext": true, - "fulltext_offset": 10416 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:7", "page": 3, - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "render_default": true, "snippet": "
SampleTANIPEGFA$ M_{n}^{a} $$ M_{w}^{a} $PDI $ ^{a} $$ \eta_{inh} $WaterConductivity
Co,"[75.0, 140.0, 1147.0, 696.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True @@ -113,17 +113,17 @@ Farasat Zaman, Email: farasat.zaman@ki","[139.0, 667.0, 1073.0, 752.0]",frontmat 18,3,text,"Next, DSC was used to determine the $ T_m $, $ T_c $, and $ X_c $ of the polymer and terpolymers from second heating cycle. DSC data is given in Table 2. Figure 4b showed the decrease in $ T_m $ a","[137.0, 786.0, 1086.0, 1035.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 18,4,number,17,"[1054.0, 1460.0, 1083.0, 1484.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 19,0,header,Journal Pre-proof,"[494.0, 67.0, 728.0, 96.0]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p19 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False -19,1,chart,,"[147.0, 151.0, 530.0, 456.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -19,2,chart,,"[563.0, 150.0, 945.0, 458.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +19,1,chart,,"[147.0, 151.0, 530.0, 456.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,2,chart,,"[563.0, 150.0, 945.0, 458.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True 19,3,figure_title,Figure 4. Thermal properties of polymer and terpolymers. (a) TGA thermograms was measured at the temperature range of 25-600 °C under nitrogen atmosphere showed thermal stability increased on increasi,"[136.0, 503.0, 1087.0, 756.0]",figure_caption,0.92,"[""figure_title label: Figure 4. Thermal properties of polymer and terpolymers. (a)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True -19,4,figure_title,Table 2. Thermal properties of the polymer and terpolymers.,"[140.0, 796.0, 772.0, 825.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 2. Thermal properties of the polymer and terpolymers.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +19,4,figure_title,Table 2. Thermal properties of the polymer and terpolymers.,"[140.0, 796.0, 772.0, 825.0]",table_caption,0.9,"[""table prefix matched: Table 2. Thermal properties of the polymer and terpolymers.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 19,5,table,
Samples$ T_{i} $$ T_{m} $$ T_{c} $$ \Delta H_{m} $$ X_{c} $
( $ ^{\circ} $C) $ ^{a} $( $ ^{\circ} $C)
Terpolymers CodesIC $ _{50} $ (mg/mL)
L-190.72
L-370.05
ES-190.10
ES-370,"[132.0, 938.0, 548.0, 1221.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True 24,7,text,Systemic administration of terpolymers prevents ROS generation in diabetic rats,"[137.0, 1294.0, 977.0, 1324.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 24,8,number,23,"[1053.0, 1459.0, 1083.0, 1484.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False @@ -197,7 +197,7 @@ Farasat Zaman, Email: farasat.zaman@ki","[139.0, 667.0, 1073.0, 752.0]",frontmat 29,4,number,28,"[1053.0, 1460.0, 1083.0, 1484.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 30,0,header,Journal Pre-proof,"[495.0, 67.0, 728.0, 96.0]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p30 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False 30,1,figure_title,(a),"[382.0, 157.0, 426.0, 198.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True -30,2,chart,,"[152.0, 204.0, 561.0, 517.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +30,2,chart,,"[152.0, 204.0, 561.0, 517.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True 30,3,figure_title,(b),"[808.0, 158.0, 856.0, 198.0]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True 30,4,image,,"[666.0, 207.0, 822.0, 349.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True 30,5,image,,"[838.0, 208.0, 992.0, 348.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True @@ -242,16 +242,16 @@ Farasat Zaman, Email: farasat.zaman@ki","[139.0, 667.0, 1073.0, 752.0]",frontmat 34,2,figure_title,Figure 14. Schematic diagram showing synthesis and characterization of electroactive and biodegradable tetra(aniline)TANI-based intrinsic antioxidant terpolymers (in fully reduced LEB state and doped ,"[135.0, 621.0, 1088.0, 1207.0]",figure_caption,0.92,"[""figure_title label: Figure 14. Schematic diagram showing synthesis and character""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,True,True 34,3,number,33,"[1053.0, 1460.0, 1083.0, 1484.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 35,0,header,Journal Pre-proof,"[494.0, 68.0, 728.0, 96.0]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p35 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False -35,1,paragraph_title,DATA AVAILABILITY,"[140.0, 145.0, 399.0, 171.0]",backmatter_heading,0.8,"[""backmatter heading on page 35: DATA AVAILABILITY""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -35,2,text,"All data supporting the findings of this study are available within the article and its supporting information, or from the corresponding author upon request.","[137.0, 201.0, 1051.0, 285.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -35,3,paragraph_title,Declaration of Competing Interest,"[140.0, 398.0, 487.0, 423.0]",body_paragraph,0.5,"[""backmatter heading on page 35: Declaration of Competing Interest""]",backmatter_heading_candidate,0.8,body_zone,heading_like,none,True,True -35,4,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[139.0, 427.0, 1043.0, 503.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -35,5,paragraph_title,ACKNOWLEDGEMENTS,"[140.0, 532.0, 430.0, 558.0]",body_paragraph,0.5,"[""backmatter heading on page 35: ACKNOWLEDGEMENTS""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -35,6,text,"Authors highly thank the Karolinska Institutet, Stockholm Sweden., Luleå University of Technology, Luleå, Sweden., higher education commission of Pakistan and Quaid-i-Azam University, Islamabad, Pakis","[137.0, 604.0, 1086.0, 798.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,1,paragraph_title,DATA AVAILABILITY,"[140.0, 145.0, 399.0, 171.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: DATA AVAILABILITY""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +35,2,text,"All data supporting the findings of this study are available within the article and its supporting information, or from the corresponding author upon request.","[137.0, 201.0, 1051.0, 285.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,3,paragraph_title,Declaration of Competing Interest,"[140.0, 398.0, 487.0, 423.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Declaration of Competing Interest""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +35,4,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[139.0, 427.0, 1043.0, 503.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,5,paragraph_title,ACKNOWLEDGEMENTS,"[140.0, 532.0, 430.0, 558.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGEMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +35,6,text,"Authors highly thank the Karolinska Institutet, Stockholm Sweden., Luleå University of Technology, Luleå, Sweden., higher education commission of Pakistan and Quaid-i-Azam University, Islamabad, Pakis","[137.0, 604.0, 1086.0, 798.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 35,7,paragraph_title,Conflicts of interest,"[140.0, 841.0, 349.0, 867.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflicts of interest""]",subsection_heading,0.6,body_zone,heading_like,none,True,True -35,8,text,The authors declare no conflicts of interest.,"[140.0, 898.0, 561.0, 925.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,8,text,The authors declare no conflicts of interest.,"[140.0, 898.0, 561.0, 925.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 35,9,paragraph_title,Contributions,"[140.0, 988.0, 292.0, 1014.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Contributions""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True -35,10,text,"I.M., $ {}^{a} $ Z.A., and F.Z., conceived the project, I.M, $ {}^{a} $ I.M., $ {}^{b} $ I.M., Z.A., S.Q., S.A., B.M., B.T.M., J.N.K., F.S, and F.Z., performed experiments, interpreted the findings","[138.0, 1050.0, 1071.0, 1107.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,10,text,"I.M., $ {}^{a} $ Z.A., and F.Z., conceived the project, I.M, $ {}^{a} $ I.M., $ {}^{b} $ I.M., Z.A., S.Q., S.A., B.M., B.T.M., J.N.K., F.S, and F.Z., performed experiments, interpreted the findings","[138.0, 1050.0, 1071.0, 1107.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True 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Adeoye AT, Ajibade TO, Oyagbemi AA, et al. The methanol leaf extract of Vernonia amygdalina ameliorates cardiomyopathy in alloxan-induced diabetic rats.","[140.0, 1263.0, 1081.0, 1312.0]",reference_item,0.85,"[""reference content label: 1. Adeoye AT, Ajibade TO, Oyagbemi AA, et al. The methanol l""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 35,13,reference_content,"2. Volpe CMO, Villar-Delfino PH, Anjos PMF, Nogueira-Machado JA. Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell death & disease 2018;9:119.","[140.0, 1316.0, 1081.0, 1365.0]",reference_item,0.85,"[""reference content label: 2. Volpe CMO, Villar-Delfino PH, Anjos PMF, Nogueira-Machado""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True @@ -357,13 +357,13 @@ Farasat Zaman, Email: farasat.zaman@ki","[139.0, 667.0, 1073.0, 752.0]",frontmat 41,0,header,Journal Pre-proof,"[494.0, 67.0, 728.0, 96.0]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p41 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False 41,1,paragraph_title,Supporting Information,"[452.0, 466.0, 772.0, 501.0]",backmatter_boundary_candidate,0.5,"[""backmatter boundary candidate: Supporting Information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True 41,2,text,Electroactive and Biocompatible Tetra(aniline)-Based Terpolymers as Intrinsic Antioxidant Drugs in Oxidative Stressed Diabetic Rats,"[138.0, 546.0, 1084.0, 633.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True -41,3,chart,,"[147.0, 676.0, 574.0, 1097.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True -41,4,chart,,"[599.0, 679.0, 1039.0, 1093.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,3,chart,,"[147.0, 676.0, 574.0, 1097.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,4,chart,,"[599.0, 679.0, 1039.0, 1093.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True 41,5,figure_title,"Figure S1. $ ^{13} $C NMR spectra (a) P-37, (b) L-37.","[138.0, 1147.0, 606.0, 1178.0]",figure_caption_candidate,0.85,"[""figure_title label: Figure S1. $ ^{13} $C NMR spectra (a) P-37, (b) L-37.""]",figure_caption,0.85,,legend_like,none,False,False 41,6,number,40,"[1053.0, 1459.0, 1083.0, 1485.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False 42,0,header,Journal Pre-proof,"[494.0, 67.0, 729.0, 97.0]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p42 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False 42,1,figure_title,Table S1. Blood glucose level (mg/dl) of different rat groups before and after treatment with antioxidant terpolymers.,"[135.0, 428.0, 1039.0, 517.0]",figure_caption_candidate,0.85,"[""figure_title label: Table S1. Blood glucose level (mg/dl) of different rat group""]",figure_caption,0.85,,table_caption_like,none,False,False -42,2,table,,"[130.0, 549.0, 881.0, 1084.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +42,2,table,
Experimental GroupInitial Glucose LevelFinal Glucose Level
Normal9798
Alloxan456478
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"mappable_block_count": 255, - "found_count": 230, - "missing_count": 25, + "mappable_block_count": 259, + "found_count": 195, + "missing_count": 64, "rows": [ { "block_id": "p2:1", "page": 2, "role": "paper_title", - "zone": "body_zone", + "zone": "frontmatter_main_zone", "render_default": true, "snippet": "Engineering electroactive and biocompatible tetra(aniline)-based terpolymers wit", "found_in_fulltext": true, @@ -16,8 +16,8 @@ { "block_id": "p2:2", "page": 2, - "role": "frontmatter_support", - "zone": "body_zone", + "role": "authors", + "zone": "frontmatter_main_zone", "render_default": true, "snippet": "Irrum Mushtaq, a* Iram Mushtaq, b Zareen Akhter, a* Iram Murtaza, b Samina Qamar", "found_in_fulltext": false, @@ -26,8 +26,8 @@ { "block_id": "p2:3", "page": 2, - "role": "frontmatter_support", - "zone": "body_zone", + "role": "affiliation", + "zone": "frontmatter_main_zone", "render_default": true, "snippet": "$ ^{a} $Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakis", "found_in_fulltext": false, @@ -36,8 +36,8 @@ { "block_id": "p2:4", "page": 2, - "role": "frontmatter_support", - "zone": "body_zone", + "role": "affiliation", + "zone": "frontmatter_main_zone", "render_default": true, "snippet": "$ ^{b} $ Department of Biochemistry, Quaid-i-Azam University, Islamabad-45320, P", "found_in_fulltext": false, @@ -46,8 +46,8 @@ { "block_id": "p2:5", "page": 2, - "role": "frontmatter_support", - "zone": "body_zone", + "role": "affiliation", + "zone": "frontmatter_main_zone", "render_default": true, "snippet": "Chemistry of Interfaces, Luleå University of Technology, SE-97187 Luleå, Sweden", "found_in_fulltext": false, @@ -56,18 +56,28 @@ { "block_id": "p2:6", "page": 2, - "role": "frontmatter_support", - "zone": "body_zone", + "role": "affiliation", + "zone": "frontmatter_main_zone", "render_default": true, "snippet": "$ ^{d} $ Department of Women’s and Children’s Health, Karolinska Institutet and ", "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p2:7", + "page": 2, + "role": "authors", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "*Corresponding authors:", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p2:9", "page": 2, "role": "noise", - 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Materials and methods", - "found_in_fulltext": true, - "fulltext_offset": 6439 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p6:5", @@ -230,8 +240,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.2. Synthesis of boc-protected amino-capped aniline tetramer (TANI)", - "found_in_fulltext": true, - "fulltext_offset": 7067 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p6:7", @@ -241,7 +251,7 @@ "render_default": true, "snippet": "The details of terpolymer synthesis steps are explained in Fig. 1. TANI was synt", "found_in_fulltext": true, - "fulltext_offset": 7136 + "fulltext_offset": 6435 }, { "block_id": "p6:8", @@ -261,7 +271,7 @@ "render_default": true, "snippet": "FTIR (solid sample, cm⁻¹) v: 3467, 3360, 3010, 2981, 2925, 1693, 1621, 1510, 145", "found_in_fulltext": true, - "fulltext_offset": 7960 + "fulltext_offset": 7259 }, { "block_id": "p7:2", @@ -271,7 +281,7 @@ "render_default": true, "snippet": "2.3. Synthesis of oligo (poly(ethylene glycol) fumarate) (PF-100)", "found_in_fulltext": true, - "fulltext_offset": 8128 + "fulltext_offset": 7427 }, { "block_id": "p7:3", @@ -290,8 +300,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.4. Synthesis of terpolymers (P-19, P-37)", - "found_in_fulltext": true, - "fulltext_offset": 8903 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p7:5", @@ -300,8 +310,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Terpolymers were synthesized by using solution polycondensation reaction as show", - "found_in_fulltext": true, - "fulltext_offset": 8946 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p7:7", @@ -311,7 +321,7 @@ "render_default": true, "snippet": "dissolved in DCM.", "found_in_fulltext": true, - "fulltext_offset": 9038 + "fulltext_offset": 8198 }, { "block_id": "p7:8", @@ -321,7 +331,7 @@ "render_default": true, "snippet": "1. PEG (dried by azeotropic distillation with dried toluene) and TANI predetermi", "found_in_fulltext": true, - "fulltext_offset": 9056 + "fulltext_offset": 8216 }, { "block_id": "p7:9", @@ -331,7 +341,7 @@ "render_default": true, "snippet": "Scheme 1. Synthesis of boc-protected and deprotected terpolymers", "found_in_fulltext": true, - "fulltext_offset": 9485 + "fulltext_offset": 8645 }, { "block_id": "p7:10", @@ -351,7 +361,7 @@ "render_default": true, "snippet": "The reaction mixture was stirred at 0 °C for 1 hour and then maintained to room ", "found_in_fulltext": true, - "fulltext_offset": 9566 + "fulltext_offset": 8726 }, { "block_id": "p8:2", @@ -361,7 +371,7 @@ "render_default": true, "snippet": "2.5. Deprotected terpolymers (L-19, L-37)", "found_in_fulltext": true, - "fulltext_offset": 10139 + "fulltext_offset": 9299 }, { "block_id": "p8:3", @@ -371,7 +381,7 @@ "render_default": true, "snippet": "Terpolymers (P-19 and P-37) were deprotected by using TFA 50 % solution in DCM a", "found_in_fulltext": true, - "fulltext_offset": 10181 + "fulltext_offset": 9341 }, { "block_id": "p8:4", @@ -380,8 +390,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.6. Characterization of engineered terpolymers", - "found_in_fulltext": true, - "fulltext_offset": 11011 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:5", @@ -390,8 +400,8 @@ "zone": "body_zone", "render_default": true, "snippet": "We next characterized the engineered terpolymers. First, FTIR spectra were recor", - "found_in_fulltext": true, - "fulltext_offset": 11059 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p8:6", @@ -411,7 +421,7 @@ "render_default": true, "snippet": "Hg/Hg₂Cl₂ (saturated calomel electrode) as the reference electrode and Pt wire a", "found_in_fulltext": true, - "fulltext_offset": 11795 + "fulltext_offset": 10183 }, { "block_id": "p9:2", @@ -421,7 +431,7 @@ "render_default": true, "snippet": "2.7. In vitro hydrolytic degradation analysis", "found_in_fulltext": true, - "fulltext_offset": 13783 + "fulltext_offset": 12171 }, { "block_id": "p9:3", @@ -441,7 +451,7 @@ "render_default": true, "snippet": "The biodegradation of the synthesized material was observed by measuring the cha", "found_in_fulltext": true, - "fulltext_offset": 13846 + "fulltext_offset": 12234 }, { "block_id": "p10:2", @@ -451,7 +461,7 @@ "render_default": true, "snippet": "2.8. Co-culture of chondrocytes with terpolymers and cellular toxicity", "found_in_fulltext": true, - "fulltext_offset": 14176 + "fulltext_offset": 12564 }, { "block_id": "p10:3", @@ -461,7 +471,7 @@ "render_default": true, "snippet": "ATDC-5 chondrocytes in proliferation stage were exposed to different concentrati", "found_in_fulltext": true, - "fulltext_offset": 14247 + "fulltext_offset": 12635 }, { "block_id": "p10:4", @@ -470,8 +480,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.9. Antioxidant (Radical scavenging activity) assay in vitro", - "found_in_fulltext": true, - "fulltext_offset": 15042 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p10:5", @@ -480,8 +490,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Antioxidant assay of the materials was determined by using a model stable free r", - "found_in_fulltext": true, - "fulltext_offset": 15104 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p10:6", @@ -501,7 +511,7 @@ "render_default": true, "snippet": "using the formula: % RSA = (A_{control} - A_{sample} / A_{Control}) × 100, where", "found_in_fulltext": true, - "fulltext_offset": 15760 + "fulltext_offset": 13443 }, { "block_id": "p11:2", @@ -511,7 +521,7 @@ "render_default": true, "snippet": "2.10. Antioxidative effects of terpolymers in diabetic rats", "found_in_fulltext": true, - "fulltext_offset": 15991 + "fulltext_offset": 13674 }, { "block_id": "p11:3", @@ -521,7 +531,7 @@ "render_default": true, "snippet": "All animal experiments were conducted according to international guidelines and ", "found_in_fulltext": true, - "fulltext_offset": 16051 + "fulltext_offset": 13734 }, { "block_id": "p11:4", @@ -530,8 +540,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.11. Blood glucose levels and oxidative and antioxidative profiling in the seru", - "found_in_fulltext": true, - "fulltext_offset": 17316 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p11:5", @@ -540,8 +550,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Blood glucose of diabetic rats was measured before and after systemic administra", - "found_in_fulltext": true, - "fulltext_offset": 17398 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p11:6", @@ -571,7 +581,7 @@ "render_default": true, "snippet": "2.12. Liver profiling, ALP analysis and histopathology of heart tissue", "found_in_fulltext": true, - "fulltext_offset": 17832 + "fulltext_offset": 15246 }, { "block_id": "p12:3", @@ -581,7 +591,7 @@ "render_default": true, "snippet": "Levels of liver enzyme Alanine Aminotransferase (ALT) and Aspartate Aminotransfe", "found_in_fulltext": true, - "fulltext_offset": 17903 + "fulltext_offset": 15317 }, { "block_id": "p12:4", @@ -590,8 +600,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.13. Statistical analysis", - "found_in_fulltext": true, - "fulltext_offset": 18813 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p12:5", @@ -600,8 +610,8 @@ "zone": "body_zone", "render_default": true, "snippet": "All statistical comparisons were performed by using GraphPad Prism 5 and statist", - "found_in_fulltext": true, - "fulltext_offset": 18840 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p12:6", @@ -621,7 +631,7 @@ "render_default": true, "snippet": "3. Results and discussion", "found_in_fulltext": true, - "fulltext_offset": 19337 + "fulltext_offset": 16243 }, { "block_id": "p13:2", @@ -631,7 +641,7 @@ "render_default": true, "snippet": "3.1. Synthesis and characterization of electroactive terpolymers", "found_in_fulltext": true, - "fulltext_offset": 19367 + "fulltext_offset": 16273 }, { "block_id": "p13:3", @@ -641,7 +651,7 @@ "render_default": true, "snippet": "PEG fumarate (PF-100), boc-protected terpolymers (P-19 and P-37), and deprotecte", "found_in_fulltext": true, - "fulltext_offset": 19432 + "fulltext_offset": 16338 }, { "block_id": "p13:4", @@ -650,8 +660,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Representative FTIR spectra are shown in Figure 1. FTIR spectrum for P-100 (Figu", - "found_in_fulltext": true, - "fulltext_offset": 20141 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p13:5", @@ -671,7 +681,7 @@ "render_default": true, "snippet": "characteristic stretches for boc-protected TANI in respective regions. The stret", "found_in_fulltext": true, - "fulltext_offset": 21250 + "fulltext_offset": 17064 }, { "block_id": "p14:2", @@ -681,7 +691,17 @@ "render_default": false, "snippet": "13", "found_in_fulltext": true, - "fulltext_offset": 7865 + "fulltext_offset": 7164 + }, + { + "block_id": "p15:5", + "page": 15, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 1. Feed ratio and characterization of polymer and terpolymers", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p15:6", @@ -721,7 +741,7 @@ "render_default": true, "snippet": "Electrochemical characterization of terpolymers", "found_in_fulltext": true, - "fulltext_offset": 23275 + "fulltext_offset": 19595 }, { "block_id": "p16:4", @@ -730,8 +750,8 @@ "zone": "body_zone", "render_default": true, "snippet": "We next assessed electrochemistry of the synthesized terpolymers by using UV-vis", - "found_in_fulltext": true, - "fulltext_offset": 23323 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p16:5", @@ -740,8 +760,8 @@ "zone": "body_zone", "render_default": true, "snippet": "On doping of the material with CSA (ES-19 and ES-37), peak at 312 nm slightly bl", - "found_in_fulltext": true, - "fulltext_offset": 23873 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p16:6", @@ -751,7 +771,7 @@ "render_default": false, "snippet": "15", "found_in_fulltext": true, - "fulltext_offset": 7911 + "fulltext_offset": 7210 }, { "block_id": "p17:1", @@ -781,7 +801,7 @@ "render_default": true, "snippet": "Thermal properties analysis", "found_in_fulltext": true, - "fulltext_offset": 24222 + "fulltext_offset": 19715 }, { "block_id": "p18:2", @@ -791,7 +811,7 @@ "render_default": true, "snippet": "We performed thermal analysis of polymers and engineered terpolymers by using TG", "found_in_fulltext": true, - "fulltext_offset": 24250 + "fulltext_offset": 19743 }, { "block_id": "p18:3", @@ -813,6 +833,16 @@ "found_in_fulltext": true, "fulltext_offset": 2756 }, + { + "block_id": "p19:4", + "page": 19, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 2. Thermal properties of the polymer and terpolymers.", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p19:6", "page": 19, @@ -831,7 +861,7 @@ "render_default": true, "snippet": "WAXD analysis was carried out to observe the effect of TANI incorporation on the", "found_in_fulltext": true, - "fulltext_offset": 25729 + "fulltext_offset": 21105 }, { "block_id": "p19:8", @@ -851,7 +881,7 @@ "render_default": true, "snippet": "increasing TANI content from 10 % to 30 %, with a shoulder appearing at 21° for ", "found_in_fulltext": true, - "fulltext_offset": 26103 + "fulltext_offset": 21894 }, { "block_id": "p20:4", @@ -860,8 +890,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Aqueous self-assembly behavior", - "found_in_fulltext": true, - "fulltext_offset": 26313 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p20:5", @@ -870,8 +900,8 @@ "zone": "body_zone", "render_default": true, "snippet": "We have recently reported that antioxidant terpolymers comprising of rigid TANI ", - "found_in_fulltext": true, - "fulltext_offset": 26344 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p20:6", @@ -891,7 +921,7 @@ "render_default": true, "snippet": "The SEM images (Figure 6A, 6B) showed the same trend of aggregate sizes i.e., L-", "found_in_fulltext": true, - "fulltext_offset": 27415 + "fulltext_offset": 22195 }, { "block_id": "p21:10", @@ -921,7 +951,7 @@ "render_default": true, "snippet": "In vitro hydrolytic degradation", "found_in_fulltext": true, - "fulltext_offset": 13788 + "fulltext_offset": 12176 }, { "block_id": "p22:2", @@ -931,7 +961,7 @@ "render_default": true, "snippet": "Terpolymers engineered herein are unique as they contain low molecular weight co", "found_in_fulltext": true, - "fulltext_offset": 28248 + "fulltext_offset": 23028 }, { "block_id": "p22:5", @@ -951,7 +981,7 @@ "render_default": true, "snippet": "Antioxidant (Radical scavenging activity) analysis", "found_in_fulltext": true, - "fulltext_offset": 29172 + "fulltext_offset": 23952 }, { "block_id": "p23:2", @@ -961,7 +991,7 @@ "render_default": true, "snippet": "To measure the antioxidant properties of these engineered terpolymers, DPPH scav", "found_in_fulltext": true, - "fulltext_offset": 29223 + "fulltext_offset": 24003 }, { "block_id": "p23:3", @@ -971,7 +1001,7 @@ "render_default": true, "snippet": "We observed that the outcomes of the reaction between DPPH⁺ and NH of TANI segme", "found_in_fulltext": true, - "fulltext_offset": 29821 + "fulltext_offset": 24601 }, { "block_id": "p23:4", @@ -1001,7 +1031,17 @@ "render_default": true, "snippet": "content and doping with CSA. Indeed, previously it has been shown that doping of", "found_in_fulltext": true, - "fulltext_offset": 30977 + "fulltext_offset": 25470 + }, + { + "block_id": "p24:5", + "page": 24, + "role": "table_caption", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Table 3. IC $ _{50} $ data of terpolymers", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p24:7", @@ -1011,7 +1051,7 @@ "render_default": true, "snippet": "Systemic administration of terpolymers prevents ROS generation in diabetic rats", "found_in_fulltext": true, - "fulltext_offset": 31234 + "fulltext_offset": 25727 }, { "block_id": "p24:8", @@ -1031,7 +1071,7 @@ "render_default": true, "snippet": "After confirming in vitro antioxidative effects of terpolymers as shown in Figur", "found_in_fulltext": true, - "fulltext_offset": 31397 + "fulltext_offset": 26024 }, { "block_id": "p25:2", @@ -1041,7 +1081,7 @@ "render_default": true, "snippet": "Therapeutic scavenging activity of terpolymers in diabetic rats", "found_in_fulltext": true, - "fulltext_offset": 33361 + "fulltext_offset": 27988 }, { "block_id": "p25:3", @@ -1051,7 +1091,7 @@ "render_default": false, "snippet": "24", "found_in_fulltext": true, - "fulltext_offset": 8848 + "fulltext_offset": 8147 }, { "block_id": "p26:1", @@ -1061,7 +1101,7 @@ "render_default": true, "snippet": "We next measured the therapeutic scavenging activity of the synthesized terpolym", "found_in_fulltext": true, - "fulltext_offset": 33442 + "fulltext_offset": 28069 }, { "block_id": "p26:2", @@ -1071,7 +1111,7 @@ "render_default": true, "snippet": "We noted that GSH activity was significantly suppressed in alloxan treated rats,", "found_in_fulltext": true, - "fulltext_offset": 34286 + "fulltext_offset": 28913 }, { "block_id": "p26:3", @@ -1081,7 +1121,7 @@ "render_default": false, "snippet": "25", "found_in_fulltext": true, - "fulltext_offset": 8015 + "fulltext_offset": 7314 }, { "block_id": "p27:1", @@ -1091,7 +1131,7 @@ "render_default": true, "snippet": "resulting into severe decrease in the total number of beta cells. All taken toge", "found_in_fulltext": true, - "fulltext_offset": 35629 + "fulltext_offset": 30256 }, { "block_id": "p27:8", @@ -1101,7 +1141,7 @@ "render_default": false, "snippet": "26", "found_in_fulltext": true, - "fulltext_offset": 7927 + "fulltext_offset": 7226 }, { "block_id": "p28:1", @@ -1121,7 +1161,7 @@ "render_default": true, "snippet": "Terpolymers improve liver profiling", "found_in_fulltext": true, - "fulltext_offset": 35896 + "fulltext_offset": 30523 }, { "block_id": "p28:3", @@ -1131,7 +1171,7 @@ "render_default": true, "snippet": "We assessed liver enzymes activity in response to systemic treatment with terpol", "found_in_fulltext": true, - "fulltext_offset": 35932 + "fulltext_offset": 30559 }, { "block_id": "p28:10", @@ -1141,7 +1181,7 @@ "render_default": false, "snippet": "Figure 10. Liver profiling in diabetic rats. Terpolymers were administered syste", "found_in_fulltext": true, - "fulltext_offset": 36711 + "fulltext_offset": 31338 }, { "block_id": "p28:11", @@ -1151,7 +1191,7 @@ "render_default": false, "snippet": "27", "found_in_fulltext": true, - "fulltext_offset": 7840 + "fulltext_offset": 7139 }, { "block_id": "p29:2", @@ -1161,7 +1201,7 @@ "render_default": true, "snippet": "Effects of terpolymers on bone health related markers", "found_in_fulltext": true, - "fulltext_offset": 36918 + "fulltext_offset": 31545 }, { "block_id": "p29:3", @@ -1171,7 +1211,7 @@ "render_default": true, "snippet": "We detected high levels of ALP in the serum of alloxan-treated rats when compare", "found_in_fulltext": true, - "fulltext_offset": 36972 + "fulltext_offset": 31599 }, { "block_id": "p29:4", @@ -1181,7 +1221,7 @@ "render_default": false, "snippet": "28", "found_in_fulltext": true, - "fulltext_offset": 7922 + "fulltext_offset": 7221 }, { "block_id": "p30:8", @@ -1201,7 +1241,7 @@ "render_default": true, "snippet": "Effects on lipid profiling and histopathological examination of heart tissues", "found_in_fulltext": true, - "fulltext_offset": 38771 + "fulltext_offset": 33398 }, { "block_id": "p30:10", @@ -1210,8 +1250,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Diabetes-induced oxidative stress affects the heart health leading to various ca", - "found_in_fulltext": false, - "fulltext_offset": -1 + "found_in_fulltext": true, + "fulltext_offset": 33476 }, { "block_id": "p30:11", @@ -1221,7 +1261,7 @@ "render_default": false, "snippet": "29", "found_in_fulltext": true, - "fulltext_offset": 8007 + "fulltext_offset": 7306 }, { "block_id": "p31:1", @@ -1251,7 +1291,7 @@ "render_default": true, "snippet": "Heart tissues stained with Haematoxylin and Eosin (H&E) as seen Figure 13a show ", "found_in_fulltext": true, - "fulltext_offset": 39114 + "fulltext_offset": 34486 }, { "block_id": "p31:10", @@ -1271,7 +1311,7 @@ "render_default": true, "snippet": "injury due to oxidative stress. 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Adeoye AT, Ajibade TO, Oyagbemi AA, et al. The methanol leaf extract of Verno", "found_in_fulltext": true, - "fulltext_offset": 42724 + "fulltext_offset": 37625 }, { "block_id": "p35:13", @@ -1471,7 +1511,7 @@ "render_default": true, "snippet": "2. Volpe CMO, Villar-Delfino PH, Anjos PMF, Nogueira-Machado JA. Cellular death,", "found_in_fulltext": true, - "fulltext_offset": 42880 + "fulltext_offset": 37781 }, { "block_id": "p35:14", @@ -1481,7 +1521,7 @@ "render_default": true, "snippet": "3. Faria A, Persaud SJ. Cardiac oxidative stress in diabetes: mechanisms and the", "found_in_fulltext": true, - "fulltext_offset": 43052 + "fulltext_offset": 37953 }, { "block_id": "p35:15", @@ -1491,7 +1531,7 @@ "render_default": false, "snippet": "34", "found_in_fulltext": true, - "fulltext_offset": 7989 + "fulltext_offset": 7288 }, { "block_id": "p36:1", @@ -1501,7 +1541,7 @@ "render_default": true, "snippet": "4. Shiekh PA, Singh A, Kumar A. 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", "found_in_fulltext": true, - "fulltext_offset": 51181 + "fulltext_offset": 44780 }, { "block_id": "p38:3", @@ -1911,7 +1951,7 @@ "render_default": true, "snippet": "43. Eelkema R, Anderson HL. Synthesis of End-Functionalized Polyanilines. Macrom", "found_in_fulltext": true, - "fulltext_offset": 51336 + "fulltext_offset": 44935 }, { "block_id": "p38:4", @@ -1920,8 +1960,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "44. Chen X, Zhou X-Y, Wu H, Lei Y-Z, Li J-H. Highly efficient reduction of nitro", - "found_in_fulltext": true, - "fulltext_offset": 51441 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p38:5", @@ -1930,8 +1970,8 @@ "zone": "reference_zone", "render_default": true, "snippet": "45. Kinard LA, Kasper FK, Mikos AG. 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Experimental GroupInitial Glucose LevelFinal Glucose Level
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Experimental GroupInitial Glucose LevelFinal Gl", @@ -2491,7 +2531,7 @@ "render_default": true, "snippet": "Graphical abstract", "found_in_fulltext": true, - "fulltext_offset": 60790 + "fulltext_offset": 52538 }, { "block_id": "p43:3", @@ -2501,7 +2541,7 @@ "render_default": true, "snippet": "42", "found_in_fulltext": true, - "fulltext_offset": 7058 + "fulltext_offset": 8130 }, { "block_id": "p44:1", @@ -2511,7 +2551,7 @@ "render_default": true, "snippet": "Highlights", "found_in_fulltext": true, - "fulltext_offset": 60832 + "fulltext_offset": 52577 }, { "block_id": "p44:2", @@ -2521,7 +2561,7 @@ "render_default": true, "snippet": "- Novel class of electroactive tetra(aniline)-based terpolymers which are not on", "found_in_fulltext": true, - "fulltext_offset": 61010 + "fulltext_offset": 52666 }, { "block_id": "p44:3", @@ -2531,7 +2571,7 @@ "render_default": true, "snippet": "• The tested terpolymers showed high antioxidative activity in diabetic rats.", "found_in_fulltext": true, - 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"p71:28", - "p71:29", - "p71:30", - "p71:31", - "p71:32", - "p71:33", - "p71:34", - "p71:35" + "p50:27" ], "findings": [ { @@ -1245,18 +522,6 @@ "artifact": "reference_span_audit.json" } }, - { - "category": "frontmatter_error", - "severity": "major", - "block_ids": [], - "truth": "page 1 should have clearer frontmatter role resolution", - "pipeline_behavior": "frontmatter page retains elevated unknown_structural density", - "root_cause_hypothesis": "frontmatter anchor or noise routing weakness", - "evidence": { - "annotated_page": "annotated_pages/page_001.png", - "artifact": "page_risk_summary.json" - } - }, { "category": "same_page_boundary_error", "severity": "major", @@ -1269,42 +534,30 @@ "artifact": "page_risk_summary.json" } }, - { - "category": "object_ownership_error", - "severity": "major", - "block_ids": [], - "truth": "figure/table ownership should map captions and assets coherently", - "pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set", - "root_cause_hypothesis": "caption-to-asset grouping ambiguity", - "evidence": { - "annotated_page": null, - "artifact": "figure_table_ownership_summary.json" - } - }, { "category": "render_mapping_error", "severity": "minor", "block_ids": [ "p1:0", "p1:2", + "p1:3", "p1:6", "p1:7", "p1:11", "p1:13", "p1:14", "p1:22", + "p1:23", "p1:24", "p2:0", "p2:1", "p2:2", "p2:3", + "p2:4", "p2:8", "p2:9", "p2:12", - "p2:15", - "p2:19", - "p2:22", - "p3:0" + "p2:15" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/SAN9AYVR/audit_report.md b/audit/SAN9AYVR/audit_report.md index 1e15bc3e..e81a11c7 100644 --- a/audit/SAN9AYVR/audit_report.md +++ b/audit/SAN9AYVR/audit_report.md @@ -2,8 +2,8 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [1, 2, 4, 6, 7, 8, 10, 11, 13, 14, 16, 17, 18, 19, 20, 23, 24, 26, 28, 30, 33, 35, 37, 39, 42, 44, 45, 47, 49, 50, 51, 53, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71] -- Reviewed blocks: 723 +- Reviewed pages: [49, 50] +- Reviewed blocks: 44 ## Findings @@ -27,9 +27,7 @@ - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region - `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals -- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output ## Disposition Guidance diff --git a/audit/SAN9AYVR/audit_scope.json b/audit/SAN9AYVR/audit_scope.json index 8336f5d6..b3b8478c 100644 --- a/audit/SAN9AYVR/audit_scope.json +++ b/audit/SAN9AYVR/audit_scope.json @@ -1,275 +1,10 @@ { "mode": "high-risk", "selected_pages": [ - 1, - 2, - 4, - 6, - 7, - 8, - 10, - 11, - 13, - 14, - 16, - 17, - 18, - 19, - 20, - 23, - 24, - 26, - 28, - 30, - 33, - 35, - 37, - 39, - 42, - 44, - 45, - 47, 49, - 50, - 51, - 53, - 55, - 56, - 57, - 58, - 59, - 60, - 61, - 62, - 63, - 64, - 65, - 66, - 67, - 68, - 69, - 70, - 71 + 50 ], "required_block_ids": [ - "p1:0", - "p1:1", - "p1:2", - "p1:3", - "p1:4", - "p1:5", - "p1:6", - "p1:7", - "p1:8", - "p1:9", - "p1:10", - "p1:11", - "p1:12", - "p1:13", - "p1:14", - "p1:15", - "p1:16", - "p1:17", - "p1:18", - "p1:19", - "p1:20", - "p1:21", - "p1:22", - "p1:23", - "p1:24", - "p1:25", - "p2:4", - "p2:6", - "p2:8", - "p2:10", - "p2:12", - "p2:13", - "p2:17", - "p2:20", - "p4:6", - "p4:7", - "p4:8", - "p4:9", - "p6:3", - "p6:4", - "p6:5", - "p6:7", - "p7:3", - "p7:4", - "p7:9", - "p8:3", - "p8:4", - "p8:6", - "p10:3", - "p10:4", - "p10:5", - "p10:6", - "p10:8", - "p10:9", - "p10:10", - "p10:11", - "p10:12", - "p10:13", - "p10:14", - "p10:15", - "p10:16", - "p10:19", - "p11:3", - "p11:5", - "p11:6", - "p11:9", - "p11:11", - "p11:12", - "p13:8", - "p13:10", - "p14:5", - "p14:9", - "p14:10", - "p16:3", - "p16:4", - "p16:5", - "p16:6", - "p16:7", - "p16:8", - "p16:9", - "p16:10", - "p16:11", - "p16:12", - "p16:15", - "p17:3", - "p17:4", - "p17:6", - "p18:2", - "p18:4", - "p19:3", - "p20:3", - "p20:4", - "p20:5", - "p20:6", - "p20:7", - "p20:8", - "p20:9", - "p20:10", - "p20:11", - "p20:12", - "p20:13", - "p20:14", - "p20:15", - "p20:16", - "p23:3", - "p23:4", - "p23:5", - "p23:6", - "p23:10", - "p24:3", - "p24:4", - "p24:5", - "p24:6", - "p24:7", - "p24:8", - "p24:9", - "p24:10", - "p24:11", - "p24:12", - "p24:13", - "p24:16", - "p26:4", - "p26:6", - "p26:7", - "p26:8", - "p26:9", - "p28:4", - "p28:5", - "p28:6", - "p28:7", - "p28:8", - "p28:9", - "p28:10", - "p28:11", - "p30:3", - "p30:4", - "p30:5", - "p30:6", - "p30:7", - "p30:8", - "p30:9", - "p30:10", - "p30:11", - "p30:12", - "p30:13", - "p33:5", - "p33:6", - "p33:7", - "p35:3", - "p35:4", - "p35:6", - "p37:3", - "p37:4", - "p37:5", - "p37:6", - "p37:7", - "p37:8", - "p37:9", - "p37:10", - "p37:11", - "p37:12", - "p37:14", - "p39:3", - "p39:4", - "p39:5", - "p39:6", - "p39:7", - "p39:8", - "p39:9", - "p39:10", - "p39:11", - "p39:12", - "p39:13", - "p39:14", - "p39:15", - "p39:16", - "p39:17", - "p39:18", - "p39:19", - "p42:3", - "p42:4", - "p42:5", - "p42:6", - "p42:7", - "p42:8", - "p42:9", - "p44:3", - "p44:4", - "p44:6", - "p44:7", - "p44:8", - "p44:9", - "p44:10", - "p44:11", - "p44:12", - "p44:17", - "p45:3", - "p45:4", - "p45:5", - "p45:6", - "p45:7", - "p45:8", - "p45:9", - "p45:10", - "p45:12", - "p47:3", - "p47:6", - "p47:8", - "p47:9", - "p47:10", - "p47:11", - "p47:13", - "p47:14", - "p47:15", - "p47:16", - "p47:17", - "p47:18", - "p47:19", "p49:3", "p49:4", "p49:5", @@ -277,3523 +12,24 @@ "p49:7", "p49:8", "p49:9", - "p49:10", - "p49:13", - "p50:4", - "p50:5", "p50:6", "p50:7", - "p50:8", "p50:9", "p50:10", "p50:11", - "p50:12", "p50:13", - "p50:14", "p50:15", "p50:16", "p50:17", "p50:18", "p50:19", - "p50:20", "p50:21", "p50:22", "p50:23", "p50:24", - "p50:25", - "p51:3", - "p51:7", - "p53:3", - "p53:4", - "p53:7", - "p55:3", - "p55:4", - "p55:6", - "p56:0", - "p56:1", - "p56:2", - "p56:3", - "p56:4", - "p56:5", - "p56:6", - "p56:7", - "p56:8", - "p56:9", - "p56:10", - "p56:11", - "p56:12", - "p56:13", - "p56:14", - "p56:15", - "p56:16", - "p56:17", - "p56:18", - "p56:19", - "p57:0", - "p57:1", - "p57:2", - "p57:3", - "p57:4", - "p57:5", - "p57:6", - "p57:7", - "p57:8", - "p57:9", - "p57:10", - "p57:11", - "p57:12", - "p57:13", - "p58:0", - "p58:1", - "p58:2", - "p58:3", - "p58:4", - "p58:5", - "p58:6", - "p58:7", - "p58:8", - "p59:0", - "p59:1", - "p59:2", - "p59:3", - "p59:4", - "p59:5", - "p59:6", - "p59:7", - "p59:8", - "p59:9", - "p60:0", - "p60:1", - "p60:2", - "p60:3", - "p60:4", - "p60:5", - "p60:6", - "p60:7", - "p60:8", - "p60:9", - "p60:10", - "p60:11", - "p60:12", - "p60:13", - "p60:14", - "p60:15", - "p61:0", - "p61:1", - "p61:2", - "p61:3", - "p61:4", - "p61:5", - "p61:6", - "p61:7", - "p61:8", - "p61:9", - "p61:10", - "p61:11", - "p61:12", - "p61:13", - "p61:14", - "p62:0", - "p62:1", - "p62:2", - "p62:3", - "p62:4", - "p62:5", - "p62:6", - "p62:7", - "p62:8", - "p62:9", - "p62:10", - "p62:11", - "p62:12", - "p62:13", - "p62:14", - "p62:15", - "p63:0", - "p63:1", - "p63:2", - "p63:3", - "p63:4", - "p63:5", - "p63:6", - "p63:7", - "p63:8", - "p63:9", - "p63:10", - "p63:11", - "p63:12", - "p64:0", - "p64:1", - "p64:2", - "p64:3", - "p64:4", - "p64:5", - "p64:6", - "p64:7", - "p64:8", - "p64:9", - "p64:10", - "p64:11", - "p65:0", - "p65:1", - "p65:2", - "p65:3", - "p65:4", - "p65:5", - "p65:6", - "p65:7", - "p65:8", - "p65:9", - "p66:0", - "p66:1", - "p66:2", - "p66:3", - "p66:4", - "p66:5", - "p67:0", - "p67:1", - "p67:2", - "p67:3", - "p67:4", - "p67:5", - "p67:6", - "p68:0", - "p68:1", - "p68:2", - "p68:3", - "p68:4", - "p68:5", - "p68:6", - "p69:0", - "p69:1", - "p69:2", - "p69:3", - "p69:4", - "p69:5", - "p69:6", - "p70:0", - "p70:1", - "p70:2", - "p70:3", - "p70:4", - "p70:5", - "p70:6", - "p70:7", - "p70:8", - "p70:9", - "p70:10", - "p70:11", - "p70:12", - "p71:5", - "p71:6", - "p71:7", - "p71:8", - "p71:9", - "p71:10", - "p71:11", - "p71:12", - "p71:13", - "p71:14", - "p71:15", - "p71:16", - "p71:17", - "p71:18", - "p71:19", - "p71:20", - "p71:21", - "p71:22", - "p71:23", - "p71:24", - "p71:25", - "p71:26", - "p71:27", - "p71:28", - "p71:29", - "p71:30", - "p71:31", - "p71:32", - "p71:33", - "p71:34", - "p71:35" + "p50:25" ], "required_blocks": [ - { - "block_id": "p1:0", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:1", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:2", - "page": 1, - "required_reason": [ - "frontmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:3", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:4", - "page": 1, - "required_reason": [ - "frontmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:5", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:6", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:7", - "page": 1, - "required_reason": [ - "frontmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:8", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:9", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:10", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:11", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:12", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:13", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:14", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:15", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:16", - "page": 1, - "required_reason": [ - "frontmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:17", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:18", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:19", - "page": 1, - "required_reason": [ - "frontmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:20", - "page": 1, - "required_reason": [ - "frontmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:21", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:22", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:23", - "page": 1, - "required_reason": [ - "frontmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:24", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p1:25", - "page": 1, - "required_reason": [ - "frontmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:4", - "page": 2, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:6", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:8", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:10", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:12", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:13", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:17", - "page": 2, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p2:20", - "page": 2, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:6", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:7", - "page": 4, - "required_reason": [ - "same_page_boundary" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p4:8", - "page": 4, - 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"page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p47:18", - "page": 47, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p47:19", - "page": 47, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p49:3", "page": 49, @@ -3899,66 +135,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p49:10", - "page": 49, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p49:13", - "page": 49, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p50:4", - "page": 50, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p50:5", - "page": 50, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p50:6", "page": 50, @@ -3989,21 +165,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p50:8", - "page": 50, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p50:9", "page": 50, @@ -4049,21 +210,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p50:12", - "page": 50, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p50:13", "page": 50, @@ -4079,21 +225,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p50:14", - "page": 50, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p50:15", "page": 50, @@ -4169,21 +300,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p50:20", - "page": 50, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p50:21", "page": 50, @@ -4258,3511 +374,18 @@ "truth_zone", "truth_reference_membership" ] - }, - { - "block_id": "p51:3", - "page": 51, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p51:7", - "page": 51, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p53:3", - "page": 53, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p53:4", - "page": 53, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p53:7", - "page": 53, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p55:3", - "page": 55, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p55:4", - "page": 55, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p55:6", - "page": 55, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p56:0", - "page": 56, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - 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b/audit/SAN9AYVR/block_coverage_summary.json @@ -212,7 +212,7 @@ "block_id": "p1:2", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", "bbox": [ 96.0, @@ -232,7 +232,7 @@ "block_id": "p1:3", "page": 1, "raw_label": "text", - "role": "frontmatter_noise", + "role": "body_paragraph", "zone": "frontmatter_main_zone", "bbox": [ 900.0, @@ -312,7 +312,7 @@ "block_id": "p1:7", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", "bbox": [ 339.0, @@ -552,7 +552,7 @@ "block_id": "p1:19", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "frontmatter_noise", "zone": "body_zone", "bbox": [ 79.0, @@ -632,7 +632,7 @@ "block_id": "p1:23", "page": 1, "raw_label": "text", - "role": "unknown_structural", + "role": "non_body_insert", "zone": "body_zone", "bbox": [ 598.0, @@ -772,7 +772,7 @@ "block_id": "p2:4", "page": 2, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -852,7 +852,7 @@ "block_id": "p2:8", "page": 2, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "non_body_insert", "zone": "", "bbox": [ 327.0, @@ -932,7 +932,7 @@ "block_id": "p2:12", "page": 2, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "non_body_insert", "zone": "frontmatter_side_zone", "bbox": [ 849.0, @@ -1092,7 +1092,7 @@ "block_id": "p2:20", "page": 2, "raw_label": "text", - "role": "unknown_structural", + "role": "frontmatter_support", "zone": "body_zone", "bbox": [ 601.0, @@ -1252,7 +1252,7 @@ "block_id": "p3:5", "page": 3, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -1572,7 +1572,7 @@ "block_id": "p4:6", "page": 4, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -1612,7 +1612,7 @@ "block_id": "p4:8", "page": 4, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 202.0, @@ -1632,7 +1632,7 @@ "block_id": "p4:9", "page": 4, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -1812,7 +1812,7 @@ "block_id": "p5:6", "page": 5, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -1992,7 +1992,7 @@ "block_id": "p6:3", "page": 6, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 230.0, @@ -2012,7 +2012,7 @@ "block_id": "p6:4", "page": 6, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "body_zone", "bbox": [ 337.0, @@ -2032,7 +2032,7 @@ "block_id": "p6:5", "page": 6, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -2072,7 +2072,7 @@ "block_id": "p6:7", "page": 6, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -2252,7 +2252,7 @@ "block_id": "p7:3", "page": 7, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 247.0, @@ -2272,7 +2272,7 @@ "block_id": "p7:4", "page": 7, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -2372,7 +2372,7 @@ "block_id": "p7:9", "page": 7, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -2512,7 +2512,7 @@ "block_id": "p8:3", "page": 8, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 119.0, @@ -2532,7 +2532,7 @@ "block_id": "p8:4", "page": 8, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 77.0, @@ -2572,7 +2572,7 @@ "block_id": "p8:6", "page": 8, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -2832,7 +2832,7 @@ "block_id": "p9:10", "page": 9, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -2992,8 +2992,8 @@ "block_id": "p10:3", "page": 10, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 182.0, 101.0, @@ -3012,7 +3012,7 @@ "block_id": "p10:4", "page": 10, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 185.0, @@ -3032,8 +3032,8 @@ "block_id": "p10:5", "page": 10, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 450.0, 98.0, @@ -3052,7 +3052,7 @@ "block_id": "p10:6", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 459.0, @@ -3092,7 +3092,7 @@ "block_id": "p10:8", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 691.0, @@ -3112,7 +3112,7 @@ "block_id": "p10:9", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 186.0, @@ -3132,7 +3132,7 @@ "block_id": "p10:10", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 453.0, @@ -3152,7 +3152,7 @@ "block_id": "p10:11", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 707.0, @@ -3172,8 +3172,8 @@ "block_id": "p10:12", "page": 10, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 181.0, 708.0, @@ -3192,7 +3192,7 @@ "block_id": "p10:13", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 171.0, @@ -3212,7 +3212,7 @@ "block_id": "p10:14", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 429.0, @@ -3232,7 +3232,7 @@ "block_id": "p10:15", "page": 10, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 727.0, @@ -3252,7 +3252,7 @@ "block_id": "p10:16", "page": 10, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 77.0, @@ -3312,7 +3312,7 @@ "block_id": "p10:19", "page": 10, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -3572,7 +3572,7 @@ "block_id": "p11:9", "page": 11, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -3892,7 +3892,7 @@ "block_id": "p12:7", "page": 12, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -4192,7 +4192,7 @@ "block_id": "p13:10", "page": 13, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -4432,7 +4432,7 @@ "block_id": "p14:5", "page": 14, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -4512,7 +4512,7 @@ "block_id": "p14:9", "page": 14, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 216.0, @@ -4532,7 +4532,7 @@ "block_id": "p14:10", "page": 14, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -4752,7 +4752,7 @@ "block_id": "p15:8", "page": 15, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -4972,7 +4972,7 @@ "block_id": "p16:3", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 150.0, @@ -4992,7 +4992,7 @@ "block_id": "p16:4", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 712.0, @@ -5012,7 +5012,7 @@ "block_id": "p16:5", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 152.0, @@ -5032,7 +5032,7 @@ "block_id": "p16:6", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 152.0, @@ -5052,7 +5052,7 @@ "block_id": "p16:7", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 385.0, @@ -5072,7 +5072,7 @@ "block_id": "p16:8", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 608.0, @@ -5092,7 +5092,7 @@ "block_id": "p16:9", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 816.0, @@ -5112,7 +5112,7 @@ "block_id": "p16:10", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 153.0, @@ -5132,7 +5132,7 @@ "block_id": "p16:11", "page": 16, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 598.0, @@ -5152,7 +5152,7 @@ "block_id": "p16:12", "page": 16, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -5212,7 +5212,7 @@ "block_id": "p16:15", "page": 16, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -5332,7 +5332,7 @@ "block_id": "p17:3", "page": 17, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 235.0, @@ -5352,7 +5352,7 @@ "block_id": "p17:4", "page": 17, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 80.0, @@ -5392,7 +5392,7 @@ "block_id": "p17:6", "page": 17, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -5492,7 +5492,7 @@ "block_id": "p18:2", "page": 18, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 91.0, @@ -5852,8 +5852,8 @@ "block_id": "p20:3", "page": 20, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 204.0, 107.0, @@ -5872,7 +5872,7 @@ "block_id": "p20:4", "page": 20, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 202.0, @@ -5892,8 +5892,8 @@ "block_id": "p20:5", "page": 20, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 587.0, 105.0, @@ -5912,7 +5912,7 @@ "block_id": "p20:6", "page": 20, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 586.0, @@ -5932,7 +5932,7 @@ "block_id": "p20:7", "page": 20, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 204.0, @@ -5952,7 +5952,7 @@ "block_id": "p20:8", "page": 20, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 635.0, @@ -5972,8 +5972,8 @@ "block_id": "p20:9", "page": 20, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 207.0, 777.0, @@ -5992,7 +5992,7 @@ "block_id": "p20:10", "page": 20, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 203.0, @@ -6012,7 +6012,7 @@ "block_id": "p20:11", "page": 20, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 430.0, @@ -6032,7 +6032,7 @@ "block_id": "p20:12", "page": 20, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 709.0, @@ -6052,7 +6052,7 @@ "block_id": "p20:13", "page": 20, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 207.0, @@ -6072,7 +6072,7 @@ "block_id": "p20:14", "page": 20, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 607.0, @@ -6092,7 +6092,7 @@ "block_id": "p20:15", "page": 20, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 789.0, @@ -6112,7 +6112,7 @@ "block_id": "p20:16", "page": 20, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -6272,7 +6272,7 @@ "block_id": "p21:5", "page": 21, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -6532,7 +6532,7 @@ "block_id": "p22:7", "page": 22, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -6732,7 +6732,7 @@ "block_id": "p23:3", "page": 23, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 174.0, @@ -6752,7 +6752,7 @@ "block_id": "p23:4", "page": 23, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 794.0, @@ -6772,7 +6772,7 @@ "block_id": "p23:5", "page": 23, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 797.0, @@ -6792,7 +6792,7 @@ "block_id": "p23:6", "page": 23, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -6872,7 +6872,7 @@ "block_id": "p23:10", "page": 23, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -7012,7 +7012,7 @@ "block_id": "p24:3", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 116.0, @@ -7032,7 +7032,7 @@ "block_id": "p24:4", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 116.0, @@ -7052,7 +7052,7 @@ "block_id": "p24:5", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 651.0, @@ -7072,7 +7072,7 @@ "block_id": "p24:6", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 942.0, @@ -7092,7 +7092,7 @@ "block_id": "p24:7", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 674.0, @@ -7112,7 +7112,7 @@ "block_id": "p24:8", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 883.0, @@ -7132,7 +7132,7 @@ "block_id": "p24:9", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 118.0, @@ -7152,7 +7152,7 @@ "block_id": "p24:10", "page": 24, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 124.0, @@ -7172,7 +7172,7 @@ "block_id": "p24:11", "page": 24, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 479.0, @@ -7192,7 +7192,7 @@ "block_id": "p24:12", "page": 24, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 945.0, @@ -7212,7 +7212,7 @@ "block_id": "p24:13", "page": 24, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -7272,7 +7272,7 @@ "block_id": "p24:16", "page": 24, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -7452,7 +7452,7 @@ "block_id": "p25:6", "page": 25, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -7672,7 +7672,7 @@ "block_id": "p26:4", "page": 26, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -7712,7 +7712,7 @@ "block_id": "p26:6", "page": 26, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 175.0, @@ -7732,7 +7732,7 @@ "block_id": "p26:7", "page": 26, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 526.0, @@ -7752,7 +7752,7 @@ "block_id": "p26:8", "page": 26, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 773.0, @@ -7772,7 +7772,7 @@ "block_id": "p26:9", "page": 26, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 80.0, @@ -7972,7 +7972,7 @@ "block_id": "p27:7", "page": 27, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -8152,7 +8152,7 @@ "block_id": "p28:4", "page": 28, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -8172,8 +8172,8 @@ "block_id": "p28:5", "page": 28, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 171.0, 399.0, @@ -8192,7 +8192,7 @@ "block_id": "p28:6", "page": 28, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 166.0, @@ -8212,8 +8212,8 @@ "block_id": "p28:7", "page": 28, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 171.0, 758.0, @@ -8232,7 +8232,7 @@ "block_id": "p28:8", "page": 28, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 318.0, @@ -8252,7 +8252,7 @@ "block_id": "p28:9", "page": 28, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 624.0, @@ -8272,7 +8272,7 @@ "block_id": "p28:10", "page": 28, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 167.0, @@ -8292,7 +8292,7 @@ "block_id": "p28:11", "page": 28, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 80.0, @@ -8532,7 +8532,7 @@ "block_id": "p29:9", "page": 29, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -8692,7 +8692,7 @@ "block_id": "p30:3", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 177.0, @@ -8712,7 +8712,7 @@ "block_id": "p30:4", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 620.0, @@ -8732,7 +8732,7 @@ "block_id": "p30:5", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 184.0, @@ -8752,7 +8752,7 @@ "block_id": "p30:6", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 512.0, @@ -8772,7 +8772,7 @@ "block_id": "p30:7", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 688.0, @@ -8792,7 +8792,7 @@ "block_id": "p30:8", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 177.0, @@ -8812,7 +8812,7 @@ "block_id": "p30:9", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 641.0, @@ -8832,7 +8832,7 @@ "block_id": "p30:10", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 177.0, @@ -8852,7 +8852,7 @@ "block_id": "p30:11", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 654.0, @@ -8872,7 +8872,7 @@ "block_id": "p30:12", "page": 30, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 176.0, @@ -8892,7 +8892,7 @@ "block_id": "p30:13", "page": 30, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -9272,7 +9272,7 @@ "block_id": "p32:7", "page": 32, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -9452,7 +9452,7 @@ "block_id": "p33:5", "page": 33, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -9472,7 +9472,7 @@ "block_id": "p33:6", "page": 33, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 116.0, @@ -9492,7 +9492,7 @@ "block_id": "p33:7", "page": 33, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -9692,7 +9692,7 @@ "block_id": "p34:7", "page": 34, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -9832,7 +9832,7 @@ "block_id": "p35:3", "page": 35, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 174.0, @@ -9852,7 +9852,7 @@ "block_id": "p35:4", "page": 35, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -9892,7 +9892,7 @@ "block_id": "p35:6", "page": 35, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -10092,7 +10092,7 @@ "block_id": "p36:7", "page": 36, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -10272,7 +10272,7 @@ "block_id": "p37:3", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 139.0, @@ -10292,7 +10292,7 @@ "block_id": "p37:4", "page": 37, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 502.0, @@ -10312,7 +10312,7 @@ "block_id": "p37:5", "page": 37, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 772.0, @@ -10332,7 +10332,7 @@ "block_id": "p37:6", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 140.0, @@ -10352,7 +10352,7 @@ "block_id": "p37:7", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 635.0, @@ -10372,7 +10372,7 @@ "block_id": "p37:8", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 633.0, @@ -10392,7 +10392,7 @@ "block_id": "p37:9", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 140.0, @@ -10412,7 +10412,7 @@ "block_id": "p37:10", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 140.0, @@ -10432,7 +10432,7 @@ "block_id": "p37:11", "page": 37, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 558.0, @@ -10452,7 +10452,7 @@ "block_id": "p37:12", "page": 37, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -10492,7 +10492,7 @@ "block_id": "p37:14", "page": 37, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -10652,7 +10652,7 @@ "block_id": "p38:5", "page": 38, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -10832,8 +10832,8 @@ "block_id": "p39:3", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 207.0, 110.0, @@ -10852,7 +10852,7 @@ "block_id": "p39:4", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 204.0, @@ -10872,8 +10872,8 @@ "block_id": "p39:5", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 525.0, 108.0, @@ -10892,7 +10892,7 @@ "block_id": "p39:6", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 524.0, @@ -10912,7 +10912,7 @@ "block_id": "p39:7", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 204.0, @@ -10932,7 +10932,7 @@ "block_id": "p39:8", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 497.0, @@ -10952,7 +10952,7 @@ "block_id": "p39:9", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 204.0, @@ -10972,7 +10972,7 @@ "block_id": "p39:10", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 462.0, @@ -10992,7 +10992,7 @@ "block_id": "p39:11", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 764.0, @@ -11012,7 +11012,7 @@ "block_id": "p39:12", "page": 39, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 205.0, @@ -11032,7 +11032,7 @@ "block_id": "p39:13", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 430.0, @@ -11052,7 +11052,7 @@ "block_id": "p39:14", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 212.0, @@ -11072,7 +11072,7 @@ "block_id": "p39:15", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 420.0, @@ -11092,7 +11092,7 @@ "block_id": "p39:16", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 601.0, @@ -11112,7 +11112,7 @@ "block_id": "p39:17", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 205.0, @@ -11132,7 +11132,7 @@ "block_id": "p39:18", "page": 39, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 601.0, @@ -11152,7 +11152,7 @@ "block_id": "p39:19", "page": 39, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -11312,7 +11312,7 @@ "block_id": "p40:5", "page": 40, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -11512,7 +11512,7 @@ "block_id": "p41:5", "page": 41, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -11692,7 +11692,7 @@ "block_id": "p42:3", "page": 42, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 223.0, @@ -11712,8 +11712,8 @@ "block_id": "p42:4", "page": 42, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 565.0, 112.0, @@ -11732,7 +11732,7 @@ "block_id": "p42:5", "page": 42, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 564.0, @@ -11752,7 +11752,7 @@ "block_id": "p42:6", "page": 42, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 561.0, @@ -11772,7 +11772,7 @@ "block_id": "p42:7", "page": 42, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 224.0, @@ -11792,7 +11792,7 @@ "block_id": "p42:8", "page": 42, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 225.0, @@ -11812,7 +11812,7 @@ "block_id": "p42:9", "page": 42, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -11992,7 +11992,7 @@ "block_id": "p43:6", "page": 43, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -12152,8 +12152,8 @@ "block_id": "p44:3", "page": 44, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 148.0, 103.0, @@ -12172,7 +12172,7 @@ "block_id": "p44:4", "page": 44, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 148.0, @@ -12212,7 +12212,7 @@ "block_id": "p44:6", "page": 44, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 752.0, @@ -12232,8 +12232,8 @@ "block_id": "p44:7", "page": 44, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 148.0, 337.0, @@ -12252,8 +12252,8 @@ "block_id": "p44:8", "page": 44, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 463.0, 340.0, @@ -12272,7 +12272,7 @@ "block_id": "p44:9", "page": 44, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 136.0, @@ -12292,7 +12292,7 @@ "block_id": "p44:10", "page": 44, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 475.0, @@ -12312,7 +12312,7 @@ "block_id": "p44:11", "page": 44, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 741.0, @@ -12332,7 +12332,7 @@ "block_id": "p44:12", "page": 44, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -12432,7 +12432,7 @@ "block_id": "p44:17", "page": 44, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -12592,7 +12592,7 @@ "block_id": "p45:3", "page": 45, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 141.0, @@ -12612,7 +12612,7 @@ "block_id": "p45:4", "page": 45, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 390.0, @@ -12652,7 +12652,7 @@ "block_id": "p45:6", "page": 45, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 141.0, @@ -12672,7 +12672,7 @@ "block_id": "p45:7", "page": 45, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 609.0, @@ -12692,7 +12692,7 @@ "block_id": "p45:8", "page": 45, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 139.0, @@ -12712,7 +12712,7 @@ "block_id": "p45:9", "page": 45, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 632.0, @@ -12732,7 +12732,7 @@ "block_id": "p45:10", "page": 45, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -12772,7 +12772,7 @@ "block_id": "p45:12", "page": 45, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -12992,7 +12992,7 @@ "block_id": "p46:7", "page": 46, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -13232,7 +13232,7 @@ "block_id": "p47:6", "page": 47, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -13272,8 +13272,8 @@ "block_id": "p47:8", "page": 47, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 172.0, 911.0, @@ -13292,7 +13292,7 @@ "block_id": "p47:9", "page": 47, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 172.0, @@ -13312,8 +13312,8 @@ "block_id": "p47:10", "page": 47, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 460.0, 907.0, @@ -13332,7 +13332,7 @@ "block_id": "p47:11", "page": 47, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 463.0, @@ -13372,7 +13372,7 @@ "block_id": "p47:13", "page": 47, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 786.0, @@ -13392,8 +13392,8 @@ "block_id": "p47:14", "page": 47, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 172.0, 1106.0, @@ -13412,7 +13412,7 @@ "block_id": "p47:15", "page": 47, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 209.0, @@ -13432,8 +13432,8 @@ "block_id": "p47:16", "page": 47, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 494.0, 1109.0, @@ -13452,7 +13452,7 @@ "block_id": "p47:17", "page": 47, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 513.0, @@ -13472,7 +13472,7 @@ "block_id": "p47:18", "page": 47, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 772.0, @@ -13492,7 +13492,7 @@ "block_id": "p47:19", "page": 47, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 80.0, @@ -13692,7 +13692,7 @@ "block_id": "p48:7", "page": 48, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 599.0, @@ -13852,7 +13852,7 @@ "block_id": "p49:3", "page": 49, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 177.0, @@ -13872,7 +13872,7 @@ "block_id": "p49:4", "page": 49, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 575.0, @@ -13892,7 +13892,7 @@ "block_id": "p49:5", "page": 49, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 177.0, @@ -13912,7 +13912,7 @@ "block_id": "p49:6", "page": 49, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 548.0, @@ -13932,7 +13932,7 @@ "block_id": "p49:7", "page": 49, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 177.0, @@ -13952,7 +13952,7 @@ "block_id": "p49:8", "page": 49, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 447.0, @@ -13972,7 +13972,7 @@ "block_id": "p49:9", "page": 49, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 717.0, @@ -13992,7 +13992,7 @@ "block_id": "p49:10", "page": 49, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -14052,7 +14052,7 @@ "block_id": "p49:13", "page": 49, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -14192,7 +14192,7 @@ "block_id": "p50:4", "page": 50, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -14212,8 +14212,8 @@ "block_id": "p50:5", "page": 50, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 181.0, 242.0, @@ -14272,8 +14272,8 @@ "block_id": "p50:8", "page": 50, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 472.0, 241.0, @@ -14352,8 +14352,8 @@ "block_id": "p50:12", "page": 50, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 183.0, 501.0, @@ -14392,8 +14392,8 @@ "block_id": "p50:14", "page": 50, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 441.0, 499.0, @@ -14512,8 +14512,8 @@ "block_id": "p50:20", "page": 50, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "body_zone", + "role": "figure_inner_text", + "zone": "display_zone", "bbox": [ 182.0, 1049.0, @@ -14612,7 +14612,7 @@ "block_id": "p50:25", "page": 50, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 751.0, @@ -14732,7 +14732,7 @@ "block_id": "p51:3", "page": 51, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 81.0, @@ -14812,7 +14812,7 @@ "block_id": "p51:7", "page": 51, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, @@ -15032,7 +15032,7 @@ "block_id": "p52:7", "page": 52, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -15252,7 +15252,7 @@ "block_id": "p53:3", "page": 53, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 139.0, @@ -15272,7 +15272,7 @@ "block_id": "p53:4", "page": 53, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -15332,7 +15332,7 @@ "block_id": "p53:7", "page": 53, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -15552,7 +15552,7 @@ "block_id": "p54:7", "page": 54, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -15712,7 +15712,7 @@ "block_id": "p55:3", "page": 55, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 135.0, @@ -15732,7 +15732,7 @@ "block_id": "p55:4", "page": 55, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -15772,7 +15772,7 @@ "block_id": "p55:6", "page": 55, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -15952,7 +15952,7 @@ "block_id": "p56:4", "page": 56, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 600.0, @@ -15972,7 +15972,7 @@ "block_id": "p56:5", "page": 56, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "tail_nonref_hold_zone", "bbox": [ 179.0, @@ -15992,7 +15992,7 @@ "block_id": "p56:6", "page": 56, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 175.0, @@ -16012,7 +16012,7 @@ "block_id": "p56:7", "page": 56, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 802.0, @@ -16032,7 +16032,7 @@ "block_id": "p56:8", "page": 56, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 800.0, @@ -16052,7 +16052,7 @@ "block_id": "p56:9", "page": 56, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "tail_nonref_hold_zone", "bbox": [ 177.0, @@ -16072,7 +16072,7 @@ "block_id": "p56:10", "page": 56, "raw_label": "chart", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 177.0, @@ -16112,7 +16112,7 @@ "block_id": "p56:12", "page": 56, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 583.0, @@ -16132,7 +16132,7 @@ "block_id": "p56:13", "page": 56, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 185.0, @@ -16152,7 +16152,7 @@ "block_id": "p56:14", "page": 56, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_inner_text", "zone": "tail_nonref_hold_zone", "bbox": [ 585.0, @@ -16172,7 +16172,7 @@ "block_id": "p56:15", "page": 56, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 583.0, @@ -16192,7 +16192,7 @@ "block_id": "p56:16", "page": 56, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 177.0, @@ -16212,7 +16212,7 @@ "block_id": "p56:17", "page": 56, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 79.0, @@ -16432,7 +16432,7 @@ "block_id": "p57:8", "page": 57, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 599.0, @@ -16632,7 +16632,7 @@ "block_id": "p58:4", "page": 58, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 600.0, @@ -16652,7 +16652,7 @@ "block_id": "p58:5", "page": 58, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 175.0, @@ -16672,7 +16672,7 @@ "block_id": "p58:6", "page": 58, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -16832,7 +16832,7 @@ "block_id": "p59:5", "page": 59, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 600.0, @@ -17092,7 +17092,7 @@ "block_id": "p60:8", "page": 60, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 601.0, @@ -17312,7 +17312,7 @@ "block_id": "p61:3", "page": 61, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 178.0, @@ -17332,7 +17332,7 @@ "block_id": "p61:4", "page": 61, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 175.0, @@ -17352,7 +17352,7 @@ "block_id": "p61:5", "page": 61, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 541.0, @@ -17372,7 +17372,7 @@ "block_id": "p61:6", "page": 61, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 814.0, @@ -17392,7 +17392,7 @@ "block_id": "p61:7", "page": 61, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 175.0, @@ -17412,7 +17412,7 @@ "block_id": "p61:8", "page": 61, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 543.0, @@ -17432,7 +17432,7 @@ "block_id": "p61:9", "page": 61, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -17472,7 +17472,7 @@ "block_id": "p61:11", "page": 61, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 600.0, @@ -17612,7 +17612,7 @@ "block_id": "p62:3", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 138.0, @@ -17632,7 +17632,7 @@ "block_id": "p62:4", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 416.0, @@ -17652,7 +17652,7 @@ "block_id": "p62:5", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 736.0, @@ -17672,7 +17672,7 @@ "block_id": "p62:6", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 143.0, @@ -17692,7 +17692,7 @@ "block_id": "p62:7", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 692.0, @@ -17712,7 +17712,7 @@ "block_id": "p62:8", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 151.0, @@ -17732,7 +17732,7 @@ "block_id": "p62:9", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 418.0, @@ -17752,7 +17752,7 @@ "block_id": "p62:10", "page": 62, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 688.0, @@ -17772,7 +17772,7 @@ "block_id": "p62:11", "page": 62, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 77.0, @@ -17812,7 +17812,7 @@ "block_id": "p62:13", "page": 62, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 600.0, @@ -18012,7 +18012,7 @@ "block_id": "p63:7", "page": 63, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 600.0, @@ -18272,7 +18272,7 @@ "block_id": "p64:7", "page": 64, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 599.0, @@ -18432,7 +18432,7 @@ "block_id": "p65:3", "page": 65, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "tail_nonref_hold_zone", "bbox": [ 139.0, @@ -18452,7 +18452,7 @@ "block_id": "p65:4", "page": 65, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 78.0, @@ -18512,7 +18512,7 @@ "block_id": "p65:7", "page": 65, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 600.0, @@ -18612,7 +18612,7 @@ "block_id": "p66:2", "page": 66, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "bbox": [ 91.0, @@ -18752,7 +18752,7 @@ "block_id": "p67:3", "page": 67, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "bbox": [ 88.0, @@ -18772,7 +18772,7 @@ "block_id": "p67:4", "page": 67, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "tail_nonref_hold_zone", "bbox": [ 132.0, @@ -18892,7 +18892,7 @@ "block_id": "p68:3", "page": 68, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "bbox": [ 88.0, @@ -18912,7 +18912,7 @@ "block_id": "p68:4", "page": 68, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "tail_nonref_hold_zone", "bbox": [ 120.0, @@ -19032,7 +19032,7 @@ "block_id": "p69:3", "page": 69, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "bbox": [ 88.0, @@ -19052,7 +19052,7 @@ "block_id": "p69:4", "page": 69, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "tail_nonref_hold_zone", "bbox": [ 128.0, @@ -19172,7 +19172,7 @@ "block_id": "p70:3", "page": 70, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "bbox": [ 90.0, @@ -19192,7 +19192,7 @@ "block_id": "p70:4", "page": 70, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "tail_nonref_hold_zone", "bbox": [ 142.0, @@ -19532,7 +19532,7 @@ "block_id": "p71:8", "page": 71, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "tail_nonref_hold_zone", "bbox": [ 81.0, @@ -19552,7 +19552,7 @@ "block_id": "p71:9", "page": 71, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 78.0, @@ -19572,7 +19572,7 @@ "block_id": "p71:10", "page": 71, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -19592,7 +19592,7 @@ "block_id": "p71:11", "page": 71, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "bbox": [ 602.0, @@ -19612,7 +19612,7 @@ "block_id": "p71:12", "page": 71, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 601.0, @@ -19632,7 +19632,7 @@ "block_id": "p71:13", "page": 71, "raw_label": "paragraph_title", - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "bbox": [ 602.0, @@ -19652,7 +19652,7 @@ "block_id": "p71:14", "page": 71, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 600.0, diff --git a/audit/SAN9AYVR/block_review.jsonl b/audit/SAN9AYVR/block_review.jsonl index 36d13107..692ad0c6 100644 --- a/audit/SAN9AYVR/block_review.jsonl +++ b/audit/SAN9AYVR/block_review.jsonl @@ -144,20 +144,20 @@ {"block_id": "p30:12", "page": 30, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_030.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p30:13", "page": 30, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_030.png", "method": "visual+bbox"}, "short_reason": "Figure caption (confirmed)", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p33:5", "page": 33, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_033.png", "method": "visual+bbox"}, "short_reason": "Empty figure/table area (misclassified)", "_current_role": "body_paragraph", "_current_zone": "body_zone", "reaudit_note": "stale truth after pdf text fallback; pipeline body_paragraph is correct", "_pipeline_verified": true} -{"block_id": "p33:6", "page": 33, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_033.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p33:6", "page": 33, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_033.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p33:7", "page": 33, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_033.png", "method": "visual+bbox"}, "short_reason": "Figure caption (confirmed)", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p35:3", "page": 35, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_035.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p35:4", "page": 35, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_035.png", "method": "visual+bbox"}, "short_reason": "Figure caption (confirmed)", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p35:6", "page": 35, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_035.png", "method": "visual+bbox"}, "short_reason": "Empty figure/table area (misclassified)", "_current_role": "body_paragraph", "_current_zone": "body_zone", "reaudit_note": "stale truth after pdf text fallback; pipeline body_paragraph is correct", "_pipeline_verified": true} -{"block_id": "p37:3", "page": 37, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_037.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p37:4", "page": 37, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_037.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p37:5", "page": 37, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_037.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} -{"block_id": "p37:6", "page": 37, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": 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{"block_id": "p37:12", "page": 37, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_037.png", "method": "visual+bbox"}, "short_reason": "Figure caption (confirmed)", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p37:14", "page": 37, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_037.png", "method": "visual+bbox"}, "short_reason": "Empty figure/table area (misclassified)", "_current_role": "body_paragraph", "_current_zone": "body_zone", "reaudit_note": "stale truth after pdf text fallback; pipeline body_paragraph is correct", "_pipeline_verified": true} {"block_id": "p39:3", "page": 39, "review_status": "reviewed", "truth_role": 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"_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p49:9", "page": 49, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_049.png", "method": "visual+bbox"}, "short_reason": "Figure/image media asset", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p49:10", "page": 49, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_049.png", "method": "visual+bbox"}, "short_reason": "Figure caption (confirmed)", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p49:13", "page": 49, "review_status": 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true, "_current_zone": "body_zone"} {"block_id": "p51:3", "page": 51, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_051.png", "method": "visual+bbox"}, "short_reason": "Figure caption (confirmed)", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p51:7", "page": 51, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_051.png", "method": "visual+bbox"}, "short_reason": "Empty figure/table area (misclassified)", "_current_role": "body_paragraph", "_current_zone": "body_zone", "reaudit_note": "stale truth after pdf text fallback; pipeline body_paragraph is correct", "_pipeline_verified": true} {"block_id": "p53:3", "page": 53, 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page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default 1,0,header,Chem Soc Rev,"[81.0, 104.0, 390.0, 146.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False 1,1,header_image,,"[817.0, 43.0, 1109.0, 128.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False -1,2,text,REVIEW ARTICLE,"[96.0, 186.0, 358.0, 221.0]",unknown_structural,0.6,"[""page-1 initial-lastname author byline: REVIEW ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True +1,2,text,REVIEW ARTICLE,"[96.0, 186.0, 358.0, 221.0]",authors,0.6,"[""page-1 initial-lastname author byline: REVIEW ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True 1,3,text,"View Article Online -View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal navigation furniture: View Article Online\nView Journal""]",frontmatter_noise,0.9,frontmatter_main_zone,support_like,none,False,False +View Journal","[900.0, 184.0, 1075.0, 230.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True 1,4,image,,"[85.0, 276.0, 277.0, 309.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True 1,5,text,Cite this: DOI: 10.1039/d4cs00413b,"[81.0, 336.0, 324.0, 355.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Cite this: DOI: 10.1039/d4cs00413b""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False -1,6,doc_title,"Bioelectronics for electrical stimulation: materials, devices and biomedical applications","[339.0, 269.0, 1101.0, 340.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Bioelectronics for electrical stimulation: materials, device""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True -1,7,text,"Ya Huang, †a Kuanming Yao, †a Qiang Zhang, ⑩†a Xingcan Huang, ⑩a Zhenlin Chen, a Yu Zhou ⑪b and Xinge Yu ⑪*a","[339.0, 360.0, 976.0, 409.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Ya Huang, \u2020a Kuanming Yao, \u2020a Qiang Zhang, \u2469\u2020a Xingcan Huang""]",authors,0.8,frontmatter_main_zone,support_like,none,False,True +1,6,doc_title,"Bioelectronics for electrical stimulation: materials, devices and biomedical applications","[339.0, 269.0, 1101.0, 340.0]",paper_title,0.8,"[""page-1 zone title_zone: Bioelectronics for electrical stimulation: materials, device""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text,"Ya Huang, †a Kuanming Yao, †a Qiang Zhang, ⑩†a Xingcan Huang, ⑩a Zhenlin Chen, a Yu Zhou ⑪b and Xinge Yu ⑪*a","[339.0, 360.0, 976.0, 409.0]",authors,0.8,"[""page-1 zone author_zone: Ya Huang, \u2020a Kuanming Yao, \u2020a Qiang Zhang, \u2469\u2020a Xingcan Huang""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,8,text,Received 30th April 2024,"[81.0, 650.0, 256.0, 670.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Received 30th April 2024""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False 1,9,abstract,"Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and tre","[339.0, 437.0, 1110.0, 745.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True 1,10,text,DOI: 10.1039/d4cs00413b,"[82.0, 682.0, 262.0, 701.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: DOI: 10.1039/d4cs00413b""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False @@ -20,26 +20,36 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 1,16,image,,"[83.0, 991.0, 312.0, 1268.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 1,17,vision_footnote,Ya Huang,"[156.0, 1277.0, 242.0, 1299.0]",footnote,0.7,"[""vision_footnote label: Ya Huang""]",footnote,0.7,body_zone,body_like,short_fragment,True,True 1,18,text,Dr Ya Huang is currently a Senior Research Fellow at the Department of Biomedical Engineering of City University of Hong Kong (CityU). She received her BS degree (2015) and PhD degree (2020) in Materi,"[327.0, 983.0, 590.0, 1316.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -1,19,text,,"[79.0, 1317.0, 588.0, 1388.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +1,19,text,"p f y +and miniaturized electrostimulation devices. She has published over +40 papers in prestigious journals like Nature, Nature Electronics, Science +Advances, etc.","[79.0, 1317.0, 588.0, 1388.0]",frontmatter_noise,0.7,"[""keyword-like block: p f y\nand miniaturized electrostimulation devices. She has p""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False 1,20,image,,"[605.0, 985.0, 834.0, 1268.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 1,21,vision_footnote,Kuanming Yao,"[657.0, 1277.0, 783.0, 1299.0]",footnote,0.7,"[""vision_footnote label: Kuanming Yao""]",footnote,0.7,body_zone,body_like,short_fragment,True,True 1,22,text,"Kuanming Yao is currently a post-doctoral researcher in the Department of Electrical & Computer Engineering in University of California, Los Angeles (UCLA). He was a postdoc in Prof. Xinge Yu's lab in","[849.0, 984.0, 1112.0, 1316.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False -1,23,text,,"[598.0, 1318.0, 1109.0, 1436.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +1,23,text,"f +monitoring and therapeutic stimulations, and wearable haptic +interfaces. He has cumulatively published over 50 journal articles, +and is serving as first/co-first author in more than 10 papers in +jou","[598.0, 1318.0, 1109.0, 1436.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False 1,24,footer,This journal is © The Royal Society of Chemistry 2024,"[83.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 1,25,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 2,0,header,Review Article,"[82.0, 49.0, 217.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False 2,1,header,View Article Online,"[991.0, 19.0, 1107.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False 2,2,header,Chem Soc Rev,"[973.0, 50.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False 2,3,text,"systems. $ ^{1-3} $ One of the most important techniques in bioelectronics is electrical stimulation (ES), a versatile and powerful technique used across a broad spectrum of medical and therapeutic ap","[79.0, 97.0, 588.0, 482.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,4,text,,"[601.0, 98.0, 1111.0, 311.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,4,text,"influence neural activity, facilitate muscle contraction, and +promote tissue repair and regeneration.18 This technique is +particularly valuable in fields such as neurology, where it is +used to treat c","[601.0, 98.0, 1111.0, 311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,5,text,"Developing bioelectronics for ES hinges on the strategic integration of electrical signals, device interfaces and design to achieve optimal performances. $ ^{11,24,25} $ The key to this process is the","[601.0, 313.0, 1111.0, 482.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,6,image,,"[84.0, 552.0, 313.0, 836.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True 2,7,vision_footnote,Qiang Zhang,"[145.0, 844.0, 253.0, 867.0]",footnote,0.7,"[""vision_footnote label: Qiang Zhang""]",footnote,0.7,frontmatter_side_zone,support_like,short_fragment,True,True -2,8,figure_title,"Dr Qiang Zhang is a postdoctoral fellow at the Department of Biomedical Engineering, CityU. He received his PhD in Biomedical Engineering from PolyU (2022) and Bachelor of Clinical Medicine (2016) and","[327.0, 550.0, 590.0, 882.0]",figure_caption_candidate,0.85,"[""figure_title label: Dr Qiang Zhang is a postdoctoral fellow at the Department of""]",figure_caption,0.85,,unknown_like,none,False,False +2,8,figure_title,"Dr Qiang Zhang is a postdoctoral fellow at the Department of Biomedical Engineering, CityU. He received his PhD in Biomedical Engineering from PolyU (2022) and Bachelor of Clinical Medicine (2016) and","[327.0, 550.0, 590.0, 882.0]",non_body_insert,0.85,"[""figure_title label: Dr Qiang Zhang is a postdoctoral fellow at the Department of""]",figure_caption,0.85,,unknown_like,none,False,False 2,9,text,integrate technologies of tissue engineering and flexible electronics to promote functional tissue repair while achieving real-time disease monitoring. 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He received his MPhil degree and bachelor's degree from Shandong University and Qing","[849.0, 550.0, 1110.0, 862.0]",figure_caption_candidate,0.85,"[""figure_title label: Xingcan Huang is currently a PhD student at the Department o""]",figure_caption,0.85,frontmatter_side_zone,support_like,none,False,False +2,12,figure_title,"Xingcan Huang is currently a PhD student at the Department of Biomedical Engineering, City University of Hong Kong. He received his MPhil degree and bachelor's degree from Shandong University and Qing","[849.0, 550.0, 1110.0, 862.0]",non_body_insert,0.85,"[""figure_title label: Xingcan Huang is currently a PhD student at the Department o""]",figure_caption,0.85,frontmatter_side_zone,support_like,none,False,False 2,13,image,,"[83.0, 1054.0, 312.0, 1341.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 2,14,vision_footnote,Zhenlin Chen,"[141.0, 1350.0, 255.0, 1369.0]",footnote,0.7,"[""vision_footnote label: Zhenlin Chen""]",footnote,0.7,body_zone,body_like,short_fragment,True,True 2,15,text,"Zhenlin Chen is currently a PhD candidate in Professor Xinge Yu's group at the Department of Biomedical Engineering, City University of Hong Kong. He received his BE degree from Harbin Engineering Uni","[328.0, 1054.0, 590.0, 1388.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False @@ -47,7 +57,8 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 2,17,image,,"[605.0, 1058.0, 835.0, 1341.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 2,18,vision_footnote,Xinge Yu,"[680.0, 1350.0, 759.0, 1370.0]",footnote,0.7,"[""vision_footnote label: Xinge Yu""]",footnote,0.7,body_zone,body_like,short_fragment,True,True 2,19,text,"Xinge Yu is the Associate Director of Institute of Digital Medicine of City University of Hong Kong, a Member of the Hong Kong Young Academy of Sciences, the recipient of RGC Research Fellow, Innovato","[849.0, 1054.0, 1112.0, 1388.0]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False -2,20,text,,"[601.0, 1390.0, 1107.0, 1437.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,20,text,"12 journals. He has published 180 papers in Nature, Nature Materials, +Nature Electronics, etc. and has filed/granted 50 patents.","[601.0, 1390.0, 1107.0, 1437.0]",frontmatter_support,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True 2,21,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 203.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 2,22,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 3,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -55,7 +66,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 3,2,header,Review Article,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,3,text,"Additionally, the bioelectronics must be capable of generating robust electrical outputs, characterized by sufficient voltage and lifespan, tailored to specific uses. A critical aspect of effective ES","[78.0, 95.0, 588.0, 1125.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,4,text,"At the cellular level, ES impacts the transmembrane potential (TMP), where a vital voltage differential across the cell membrane is essential for biofunctions such as communication, growth, and metabo","[78.0, 1125.0, 589.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,5,text,,"[600.0, 98.0, 1111.0, 431.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +3,5,text,"Building on these biological and electrical foundational con- +cepts, bioelectronics engineered with optimal physicochemical +properties can effectively deliver ES to cells, tissues, and organs, +enhancin","[600.0, 98.0, 1111.0, 431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,6,text,"Section 4 catalogues a diverse array of materials utilized in bioelectronics for ES, including metals, metal oxides, carbon materials, conductive polymers, semiconductors, and their hybrids. The selec","[600.0, 432.0, 1110.0, 647.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,7,text,"In Section 5, the focus is on ES based bioelectronics for tissue regeneration, merging biology and engineering to develop functional replacements for damaged tissues that mimic the architecture and fu","[600.0, 648.0, 1111.0, 838.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,8,text,"Section 6 delves into neuromodulation via ES, a versatile medical technique that alters nerve activity to modulate neurological and psychiatric conditions, influencing neural circuits for symptom alle","[600.0, 840.0, 1111.0, 1030.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -71,10 +85,12 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 4,3,text,"exists in all living cells, which is regulated through a delicate balance between the accumulation of various ion concentrations inside and outside the cells. $ ^{57} $ Consequently, when applying an ","[78.0, 97.0, 589.0, 386.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,4,paragraph_title,2.1. Effects of ES on cell behaviors,"[79.0, 400.0, 379.0, 423.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Effects of ES on cell behaviors""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 4,5,text,"2.1.1. Cell alignment and migration. Guided cell alignment and migration play pivotal roles in the field of regenerative medicine since they directly participate in embryonic development, tissue forma","[78.0, 431.0, 588.0, 913.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True -4,6,text,,"[600.0, 97.0, 1111.0, 311.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,6,text,"gradients.59,68–70 Conversely, ventricular myocytes, cardiomyocytes, +myoblasts, and osteoblasts exhibit a distinctive tendency to align +themselves parallel to the electric field vectors, which is main","[600.0, 97.0, 1111.0, 311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,7,text,"Likewise, ES affects the cell migration, $ ^{75} $ and its directional migration in response to ES is commonly referred to as electrotaxis. $ ^{76} $ It is crucial to acknowledge that the impact of ES","[598.0, 312.0, 1112.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,8,image,,"[202.0, 968.0, 988.0, 1401.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -4,9,figure_title,Fig. 1 The molecular and cellular-level changes activated by ES.,"[79.0, 1414.0, 532.0, 1436.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 1 The molecular and cellular-level changes activated by""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +4,8,image,,"[202.0, 968.0, 988.0, 1401.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,9,figure_title,Fig. 1 The molecular and cellular-level changes activated by ES.,"[79.0, 1414.0, 532.0, 1436.0]",figure_caption,0.92,"[""figure_title label: Fig. 1 The molecular and cellular-level changes activated by""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 4,10,footer,Chem. Soc. Rev.,"[82.0, 1493.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 4,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1493.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 5,0,header,Chem Soc Rev,"[82.0, 49.0, 219.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -83,7 +99,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 5,3,text,"and receptors) and interactions with signal transduction pathways (e.g., Wnt/GSK3 $ \beta $/ $ \beta $-catenin and TGF $ \beta $1/ERK/NF- $ \kappa $B signaling pathways) play a pivotal role in orchest","[78.0, 97.0, 588.0, 215.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,4,text,"2.1.2. Cell proliferation and apoptosis. Despite widespread evidence suggesting that ES primarily boosts cell proliferation without affecting the phenotype, particularly under continuous stimulation a","[78.0, 218.0, 589.0, 1029.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True 5,5,text,"2.1.3. Cell differentiation. ES-induced cell differentiation represents a highly promising strategy in the field of tissue engineering, as it facilitates the integration of cells with scaffolds ex viv","[78.0, 1031.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True -5,6,text,,"[600.0, 98.0, 1112.0, 526.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +5,6,text,"the osteogenic lineage rather than cartilage, which is character- +ized by increased levels of alkaline phosphatase and collagen +type I.106,107 Additionally, many studies have demonstrated that +appropr","[600.0, 98.0, 1112.0, 526.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,7,text,2.1.4. Cell attachment. Cell attachment has been recognized as an important factor that significantly impacts cellular behaviors and functions. The surface micro-topological morphology of 3D scaffolds,"[600.0, 529.0, 1112.0, 1152.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True 5,8,paragraph_title,2.2. Molecular mechanisms of cellular responses to ES,"[600.0, 1167.0, 1062.0, 1189.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Molecular mechanisms of cellular responses to ES""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 5,9,text,"The underlying mechanisms that govern the cellular responses to ES are currently the focus of ongoing research. $ ^{125,126} $ Here, we summarize some critical hypotheses or views and discuss concisel","[600.0, 1197.0, 1112.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -92,11 +111,14 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 6,0,header,Review Article,"[81.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,1,header,View Article Online,"[990.0, 19.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 72.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -6,3,image,,"[230.0, 106.0, 947.0, 469.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -6,4,figure_title,"c. Redistribution of surface receptors, lipid rafts and actins","[337.0, 485.0, 821.0, 509.0]",figure_caption_candidate,0.85,"[""figure_title label: c. Redistribution of surface receptors, lipid rafts and acti""]",figure_caption,0.85,body_zone,legend_like,heading_roman,False,False -6,5,figure_title,"Fig. 2 Possible mechanisms of cellular responses to ES. (a) Activation of signal transduction pathways. (b) Ion flow. (c) Redistribution of surface receptors, lipid rafts and actins. (d) Enhanced ATP ","[78.0, 517.0, 1107.0, 559.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 2 Possible mechanisms of cellular responses to ES. (a) ""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +6,3,image,,"[230.0, 106.0, 947.0, 469.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +6,4,figure_title,"c. Redistribution of surface receptors, lipid rafts and actins","[337.0, 485.0, 821.0, 509.0]",figure_caption,0.85,"[""figure_title label: c. Redistribution of surface receptors, lipid rafts and acti""]",figure_caption,0.85,body_zone,legend_like,heading_roman,True,True +6,5,figure_title,"Fig. 2 Possible mechanisms of cellular responses to ES. (a) Activation of signal transduction pathways. (b) Ion flow. (c) Redistribution of surface receptors, lipid rafts and actins. (d) Enhanced ATP ","[78.0, 517.0, 1107.0, 559.0]",figure_caption,0.92,"[""figure_title label: Fig. 2 Possible mechanisms of cellular responses to ES. (a) ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 6,6,text,"subsequently induces the expression of extracellular signal-regulated kinase, p38 mitogen activated kinase, PI3 kinase, etc. $ ^{127,128} $ Depending on the specific cell types and stimulation paramet","[78.0, 601.0, 589.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -6,7,text,,"[600.0, 598.0, 1110.0, 720.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +6,7,text,"by Leppik et al.126 and Zhao et al.129 Altogether, these putative +cellular mechanisms are intricately intertwined within a +complex but meticulously orchestrated network that trans- +forms the external ","[600.0, 598.0, 1110.0, 720.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,8,paragraph_title,2.3. Conventional methods to deliver ES in vitro,"[601.0, 736.0, 1010.0, 758.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Conventional methods to deliver ES in vitro""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 6,9,text,"In most in vitro studies, cells are cultivated in either 2D or 3D microenvironments, providing specific regimens of ES within purpose-built chambers. The conventional methods for ES delivery can be pr","[600.0, 768.0, 1111.0, 1315.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,10,text,"Compared with direct coupling, capacitive coupling is biologically safer for ES. $ ^{147,148} $ As illustrated in Fig. 3b, in the setup of capacitive coupling, two electrodes are placed at opposite en","[599.0, 1317.0, 1111.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -105,23 +127,29 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 7,0,header,Chem Soc Rev,"[81.0, 49.0, 219.0, 72.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 7,1,header,View Article Online,"[990.0, 19.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 7,2,header,Review Article,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -7,3,image,,"[247.0, 93.0, 958.0, 482.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -7,4,figure_title,"Fig. 3 Typical ways to deliver ES for cell behavior regulation, including (a) direct coupling, (b) capacitive coupling, and (c) inducible coupling by utilization of an electromagnetic field.","[78.0, 500.0, 1107.0, 543.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 3 Typical ways to deliver ES for cell behavior regulati""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +7,3,image,,"[247.0, 93.0, 958.0, 482.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,4,figure_title,"Fig. 3 Typical ways to deliver ES for cell behavior regulation, including (a) direct coupling, (b) capacitive coupling, and (c) inducible coupling by utilization of an electromagnetic field.","[78.0, 500.0, 1107.0, 543.0]",figure_caption,0.92,"[""figure_title label: Fig. 3 Typical ways to deliver ES for cell behavior regulati""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 7,5,text,"indirect contact with the medium, this system prevents cells from being exposed to toxic electrochemical byproducts and pH fluctuations. $ ^{147} $ More importantly, the capacitive coupling system is ","[78.0, 575.0, 589.0, 910.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,6,text,"Inductive coupling is another method for in vitro ES, which commonly involves the utilization of a conductive coil positioned around the cell culture system to generate a controllable electromagnetic ","[77.0, 911.0, 589.0, 1246.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,7,paragraph_title,2.4. Novel platforms for manipulation of cell behaviors,"[79.0, 1262.0, 543.0, 1284.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Novel platforms for manipulation of cell behaviors""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 7,8,text,"The above ES devices necessitate an external power supply to connect electrodes and/or coils, for applying an electric field, which are restrained by their inherent drawbacks like bulky size, high cos","[77.0, 1293.0, 589.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -7,9,text,,"[600.0, 576.0, 1112.0, 1172.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +7,9,text,"to take out the device and replace the old battery with a new one, +once the battery runs out of power. The potential leakage of the +battery may also lead to concerns of biosafety, since most of the +st","[600.0, 576.0, 1112.0, 1172.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,10,text,"The conventional cell culture platforms employed to assess the effects of ES are predominantly 2D in nature, typically established by directly seeding cells onto culture dishes. $ ^{168} $ Despite the","[599.0, 1173.0, 1112.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,11,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 481.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 7,12,footer,Chem. Soc. Rev.,"[986.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,0,header,Review Article,"[82.0, 50.0, 217.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,2,header,Chem Soc Rev,"[973.0, 50.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -8,3,image,,"[119.0, 102.0, 1076.0, 865.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -8,4,figure_title,Fig. 4 Novel in vitro ES platforms to regulate cell behaviors. (a) A TENG-based platform for suppressing in vitro cancer cell migration and in vivo tumor metastasis. $ ^{[151]} $ (i) Schematic illustr,"[77.0, 878.0, 1113.0, 1100.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 4 Novel in vitro ES platforms to regulate cell behavior""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +8,3,image,,"[119.0, 102.0, 1076.0, 865.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +8,4,figure_title,Fig. 4 Novel in vitro ES platforms to regulate cell behaviors. (a) A TENG-based platform for suppressing in vitro cancer cell migration and in vivo tumor metastasis. $ ^{[151]} $ (i) Schematic illustr,"[77.0, 878.0, 1113.0, 1100.0]",figure_caption,0.92,"[""figure_title label: Fig. 4 Novel in vitro ES platforms to regulate cell behavior""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 8,5,text,"materials, $ ^{174} $ and their composites, $ ^{175-177} $ to better mimic the architectural and chemical intricacies observed in living tissues. For example, Dutta et al. fabricated a full-thickness ","[77.0, 1148.0, 589.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,6,text,,"[600.0, 1148.0, 1112.0, 1439.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,6,text,"network.168 Currently, there is an increasing number of studies +that utilized microfluidic devices to fabricate 3D tissue models for +ES, commonly known as ‘‘tissue-on-a-chip’’.178,179 These models +off","[600.0, 1148.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,7,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,8,footer,This journal is © The Royal Society of Chemistry 2024,"[711.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 9,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -134,7 +162,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 9,7,paragraph_title,3.1. Electrode-tissue interfaces,"[80.0, 1119.0, 349.0, 1141.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Electrode-tissue interfaces""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 9,8,text,"Different from cells cultured in vitro, all tissues such as muscles, neurons and skin are in a complex aqueous microenvironment containing water, electrolytes, and various kinds of physical and chemic","[78.0, 1149.0, 588.0, 1268.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,9,text,"3.1.1. Stimulation electrode interface modelling. Taking a neurostimulator as an example, it could be viewed as an electrochemical cell that is tested using a potentiostat or galvanostat (Fig. 5a). $ ","[78.0, 1270.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True -9,10,text,,"[601.0, 97.0, 1111.0, 239.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +9,10,text,"These can be analogized to the working electrode (WE) and +counter electrode (CE) in an electrochemical cell. Although +tissues exhibit anisotropic properties that differ from those of +a salt solution, t","[601.0, 97.0, 1111.0, 239.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,11,text,"Considering a pair of solid metal electrodes that are brought into contact with a liquid electrolyte solution, Boehler et al. built up an equivalent circuit model for describing the electricity pathwa","[599.0, 241.0, 1111.0, 887.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,12,text,"As mentioned above, the interfacial impedance between bioelectronics and tissue is lower at higher frequencies, which can be beneficial for current transmission in both directions (from bioelectronics","[600.0, 888.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,13,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -142,23 +173,26 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 10,0,header,Review Article,"[82.0, 49.0, 217.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 10,1,header,View Article Online,"[991.0, 20.0, 1107.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 10,2,header,Chem Soc Rev,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -10,3,figure_title,a,"[182.0, 101.0, 199.0, 119.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -10,4,image,,"[185.0, 103.0, 447.0, 417.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -10,5,figure_title,b,"[450.0, 98.0, 466.0, 119.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -10,6,chart,,"[459.0, 100.0, 673.0, 418.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,3,figure_title,a,"[182.0, 101.0, 199.0, 119.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,4,image,,"[185.0, 103.0, 447.0, 417.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,5,figure_title,b,"[450.0, 98.0, 466.0, 119.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,6,chart,,"[459.0, 100.0, 673.0, 418.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 10,7,figure_title,C,"[695.0, 101.0, 711.0, 120.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True -10,8,chart,,"[691.0, 104.0, 986.0, 431.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -10,9,chart,,"[186.0, 436.0, 454.0, 706.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True -10,10,chart,,"[453.0, 440.0, 702.0, 692.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True -10,11,chart,,"[707.0, 457.0, 987.0, 699.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -10,12,figure_title,g,"[181.0, 708.0, 198.0, 729.0]",figure_caption_candidate,0.85,"[""figure_title label: g""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False -10,13,chart,,"[171.0, 711.0, 419.0, 927.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True -10,14,chart,,"[429.0, 700.0, 686.0, 925.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True -10,15,chart,,"[727.0, 728.0, 1019.0, 910.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -10,16,figure_title,Fig. 5 Stimulation electrode interface modelling. (a) Principle of stimulation with a neural interface. (b) The equivalent circuit model of the electrode–tissue interface and schematic of different ch,"[77.0, 935.0, 1109.0, 1097.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 5 Stimulation electrode interface modelling. (a) Princi""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +10,8,chart,,"[691.0, 104.0, 986.0, 431.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,9,chart,,"[186.0, 436.0, 454.0, 706.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,10,chart,,"[453.0, 440.0, 702.0, 692.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,11,chart,,"[707.0, 457.0, 987.0, 699.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,12,figure_title,g,"[181.0, 708.0, 198.0, 729.0]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,13,chart,,"[171.0, 711.0, 419.0, 927.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,14,chart,,"[429.0, 700.0, 686.0, 925.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,15,chart,,"[727.0, 728.0, 1019.0, 910.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,16,figure_title,Fig. 5 Stimulation electrode interface modelling. (a) Principle of stimulation with a neural interface. (b) The equivalent circuit model of the electrode–tissue interface and schematic of different ch,"[77.0, 935.0, 1109.0, 1097.0]",figure_caption,0.92,"[""figure_title label: Fig. 5 Stimulation electrode interface modelling. (a) Princi""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 10,17,text,"Additionally, phase shifts in the received signal at higher frequencies can cause significant distortion and delay, necessitating a lower sampling frequency for accurate and timely sensing.","[79.0, 1149.0, 587.0, 1220.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,18,text,"Capacitive coupling is not the only contributor to the charge transfer. Direct faradaic currents that involve redox chemical reactions could also exist in parallel with the capacitors; thus, the inter","[79.0, 1222.0, 588.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,19,text,,"[601.0, 1150.0, 1110.0, 1388.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,19,text,"multiple parallelly connected impedances. Faradaic currents +that cause electrode corrosion, changes in electrolyte composi- +tion, or gas generation at the interface should be avoided, +especially in lo","[601.0, 1150.0, 1110.0, 1388.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,20,text,3.1.2. Essential electrical characteristics of ES interfaces. For evaluating the electrical performance of the electrodes at,"[601.0, 1390.0, 1111.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True 10,21,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 203.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 10,22,footer,This journal is © The Royal Society of Chemistry 2024,"[711.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -171,7 +205,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 11,6,formula_number,(1),"[546.0, 861.0, 569.0, 884.0]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True 11,7,text,"The measured spectrum also has the phase shift part plotted on a linear scale. These two parts comprise the Bode plot that reflects the transfer function of the interface, which means how smoothly cha","[78.0, 910.0, 588.0, 1054.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,8,text,"For characterizing the charge injection performances, methods like the charge-balanced stimulation test or pulse-clamp test could be used. $ ^{8} $ To know about the characterization mechanism, we fir","[78.0, 1056.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,9,text,,"[601.0, 98.0, 1111.0, 479.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +11,9,text,"second half (a positive pulse with the same charge amount) by +switching the polarity. The second half often has a longer dura- +tion and lower amplitude to reduce the necessary voltage excur- +sion in t","[601.0, 98.0, 1111.0, 479.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,10,text,"As all biological tissues contain water, we can consider it as an aqueous environment. Thus, the most common irreversible faradaic reaction that happens in all electrode-tissue interfaces is the elect","[600.0, 480.0, 1110.0, 575.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,11,display_formula, $$ \mathrm{2H_{2}O +2e^{-} \leftrightarrow H_{2} +2OH^{-} (reduction)} $$ ,"[696.0, 587.0, 1016.0, 611.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True 11,12,display_formula, $$ 2H_{2}O\leftrightarrow O_{2}+4H^{+}+4e^{-}\left(oxidation\right) $$ ,"[704.0, 635.0, 1006.0, 659.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True @@ -187,7 +224,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 12,4,text,"Apart from the above-mentioned reversible faradaic reactions, other factors also exist that could affect the charge injection behavior whether reversible or irreversible. These factors include the tem","[79.0, 217.0, 588.0, 407.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,5,text,"The CIC $ _{max} $ could be determined by a charge-balanced stimulation test as mentioned above. A current-controlled charge-balanced biphasic pulse is applied on the WE-CE circuit, where the CE is as","[79.0, 408.0, 588.0, 1055.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,6,text,"Although the charge-balanced stimulation test could reveal $ CIC_{max} $, there are still faradaic currents within the water window and their portion in the total charge transfer can't be reflected i","[78.0, 1056.0, 587.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -12,7,text,,"[600.0, 99.0, 1111.0, 287.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +12,7,text,"many charges are slowly or cannot be recovered. Typically, the +fast recoverable charge is attributed to EDL capacitive coupling, +the slowly recoverable charge correlates to reversible faradaic +reactio","[600.0, 99.0, 1111.0, 287.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,8,text,"For characterizing the electrochemical active area, experimental methods such as cyclic voltammetry (CV) could be used. $ ^{200} $ The CV method is used to drive the electrode voltage (potential) to s","[599.0, 289.0, 1112.0, 1054.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,9,text,"CV peaks could be used to analyze how the faradaic reactions change with varying parameters such as pH, concentrations, or product diffusion. $ ^{201} $ They could also be used to estimate the increas","[600.0, 1056.0, 1112.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,10,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -202,7 +242,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 13,7,text,The Shannon model of neuronal damage describes the relationship between charge density per phase (CDPP) and charge per phase (CPP) in determining the level of neuronal injury. According to Shannon's m,"[78.0, 1174.0, 588.0, 1319.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,8,display_formula," $$ \log(D)=k-\log(Q), $$ ","[251.0, 1341.0, 416.0, 1366.0]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True 13,9,text,"where D is the CDPP, Q is the CPP, and k is a constant that is derived experimentally. $ ^{205} $ This model suggests that there is a critical threshold defined by k that separates stimulation paramet","[78.0, 1389.0, 588.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -13,10,text,,"[600.0, 98.0, 1110.0, 216.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +13,10,text,"critical threshold defined by k that separates stimulation para- +meters that lead to tissue damage from those that do not +(Fig. 5g).206 This model is important in understanding the +impact of ES on neu","[600.0, 98.0, 1110.0, 216.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,11,text,"Electrodes can experience various failure modes depending on the type of material used, such as a metal or a polymer. $ ^{202} $ On one hand, metal electrodes, such as Pt, can be susceptible to corros","[600.0, 217.0, 1111.0, 743.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,12,text,"Electrode failure modes at the interface and substrate result from various mechanisms, including surface or bulk material degradation and issues related to adhesive bonding (Fig. 5i). $ ^{184} $ Delam","[600.0, 743.0, 1111.0, 1078.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,13,text,Characterizing the stability of electrodes involves a comprehensive approach that considers various factors to ensure reliable performance over time. The deposition and manufacturing technology of ele,"[600.0, 1079.0, 1111.0, 1365.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -214,12 +257,14 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 14,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 14,3,text,"material degradation over time. The Arrhenius equation describes how the rate constant of a chemical reaction varied with temperature. Specifically, the rate constant increases exponentially as the ac","[78.0, 97.0, 588.0, 432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,4,text,"When assessing performance, high-resolution imaging techniques like scanning electron microscopy (SEM) can be utilized to verify stability and surface changes post-stimulation. $ ^{213} $ Additionally","[78.0, 432.0, 589.0, 746.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -14,5,text,,"[599.0, 97.0, 1111.0, 169.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +14,5,text,"performance tests due to its relevance to the ionic composition of +the extracellular fluid, complementary measurements in more +complex electrolytes may be necessary for specific applications.","[599.0, 97.0, 1111.0, 169.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,6,paragraph_title,3.2. Stimulation parameters,"[602.0, 187.0, 846.0, 209.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Stimulation parameters""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 14,7,text,"The parameters of ES, including intensity, duration, waveforms, and frequency, require meticulous optimization to effectively trigger the desired biological responses. Careful calibration not only ens","[600.0, 219.0, 1111.0, 360.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 14,8,text,"The cathodic monophasic waveform is highly effective for stimulation (Fig. 6a(i)). It involves unidirectional current pulses, avoiding reverse current flow. $ ^{19} $ During monophasic stimulation, re","[600.0, 361.0, 1112.0, 747.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -14,9,image,,"[216.0, 773.0, 934.0, 1428.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -14,10,figure_title,"Fig. 6 Typical stimulation waveforms. (a) Pulsed waveform classification regarding the polarity, charge balance and interphase delay. $ ^{19} $ Adapted from ref. 19 with permission from Elsevier, copy","[78.0, 1393.0, 1107.0, 1436.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 6 Typical stimulation waveforms. (a) Pulsed waveform cl""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +14,9,image,,"[216.0, 773.0, 934.0, 1428.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +14,10,figure_title,"Fig. 6 Typical stimulation waveforms. (a) Pulsed waveform classification regarding the polarity, charge balance and interphase delay. $ ^{19} $ Adapted from ref. 19 with permission from Elsevier, copy","[78.0, 1393.0, 1107.0, 1436.0]",figure_caption,0.92,"[""figure_title label: Fig. 6 Typical stimulation waveforms. (a) Pulsed waveform cl""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 14,11,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 14,12,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 15,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -230,7 +275,8 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 15,5,text,"Biphasic symmetric waveforms (Fig. 6b(i)) consist of equal charge/phase for both positive and negative phases, ensuring charge balance of the waveform. $ ^{20} $ These waveforms typically have a leadi","[78.0, 384.0, 588.0, 912.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 15,6,paragraph_title,4. Materials and their key performances for ES based bioelectronics,"[80.0, 967.0, 437.0, 1061.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Materials and their key performances for ES based bioelec""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True 15,7,text,"Metals, metal oxides, carbon materials, conductive polymers, semiconductors and their hybrid materials, etc. have been widely used for ES delivery. $ ^{215} $ These materials have their own distinct a","[78.0, 1079.0, 588.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -15,8,text,,"[600.0, 97.0, 1109.0, 146.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +15,8,text,"in the selection of appropriate materials and structure design +for development of next-generation ES systems.","[600.0, 97.0, 1109.0, 146.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 15,9,paragraph_title,4.1. Electrical performances,"[602.0, 162.0, 846.0, 184.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.1. Electrical performances""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 15,10,text,"Electrical performances are the key characteristics essential for the development of ES electrodes, which form the electrical communication from the device to the human body. $ ^{216} $ In Section 3.1","[600.0, 193.0, 1110.0, 431.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 15,11,text,"Metals, especially noble metals like gold (Au), silver (Ag), platinum (Pt), and palladium (Pd), are the most common electrode materials for ES by virtue of their high electrical conductivity. $ ^{184,","[600.0, 432.0, 1111.0, 911.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -241,33 +287,39 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 16,0,header,Review Article,"[82.0, 49.0, 217.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 16,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 16,2,header,Chem Soc Rev,"[973.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -16,3,image,,"[150.0, 105.0, 687.0, 325.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -16,4,image,,"[712.0, 106.0, 1040.0, 323.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -16,5,image,,"[152.0, 343.0, 1040.0, 531.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -16,6,image,,"[152.0, 550.0, 381.0, 755.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -16,7,image,,"[385.0, 554.0, 599.0, 752.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -16,8,image,,"[608.0, 582.0, 803.0, 753.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -16,9,image,,"[816.0, 565.0, 1036.0, 753.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -16,10,image,,"[153.0, 773.0, 581.0, 964.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -16,11,image,,"[598.0, 774.0, 1038.0, 968.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -16,12,figure_title,"Fig. 7 Design principles for ES systems with desirable physicochemical and biological performances. Key properties for development of ES systems, including (a) electrical performances such as high ele","[78.0, 976.0, 1112.0, 1120.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 7 Design principles for ES systems with desirable physi""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +16,3,image,,"[150.0, 105.0, 687.0, 325.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,4,image,,"[712.0, 106.0, 1040.0, 323.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,5,image,,"[152.0, 343.0, 1040.0, 531.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +16,6,image,,"[152.0, 550.0, 381.0, 755.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +16,7,image,,"[385.0, 554.0, 599.0, 752.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +16,8,image,,"[608.0, 582.0, 803.0, 753.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,9,image,,"[816.0, 565.0, 1036.0, 753.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,10,image,,"[153.0, 773.0, 581.0, 964.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,11,image,,"[598.0, 774.0, 1038.0, 968.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,12,figure_title,"Fig. 7 Design principles for ES systems with desirable physicochemical and biological performances. Key properties for development of ES systems, including (a) electrical performances such as high ele","[78.0, 976.0, 1112.0, 1120.0]",figure_caption,0.92,"[""figure_title label: Fig. 7 Design principles for ES systems with desirable physi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 16,13,text,"further improved. $ ^{253} $ Recently, a molybdenum disulfide (MoS $ _2 $)-based floating-gate memory interdigital circuit, poly(3-hexylthiophene) (P3HT)-based nanofibers, and TiN-based film electrode","[79.0, 1148.0, 588.0, 1316.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 16,14,text,"Conducting polymers feature a distinct class of organic polymers with a conjugated backbone. $ ^{259,260} $ They possess outstanding electrical and optical characteristics comparable to those found in","[78.0, 1318.0, 589.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -16,15,text,,"[599.0, 1149.0, 1112.0, 1439.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +16,15,text,"resulting in the generation of positive charges along the polymer +backbone. To maintain a charge-neutral state, negatively charged +ions, commonly known as stabilizing counter ions, are doped into +the ","[599.0, 1149.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 16,16,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 16,17,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 17,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 17,1,header,View Article Online,"[990.0, 19.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 17,2,header,Review Article,"[973.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -17,3,image,,"[235.0, 107.0, 952.0, 807.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -17,4,figure_title,Fig. 8 Common electroactive materials as building blocks for ES systems.,"[80.0, 833.0, 597.0, 855.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 8 Common electroactive materials as building blocks for""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +17,3,image,,"[235.0, 107.0, 952.0, 807.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +17,4,figure_title,Fig. 8 Common electroactive materials as building blocks for ES systems.,"[80.0, 833.0, 597.0, 855.0]",figure_caption,0.92,"[""figure_title label: Fig. 8 Common electroactive materials as building blocks for""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 17,5,text,"injection limit, making them highly favorable for ES applications. In addition, it is easy to deposit PEDOT onto various substrates by electro-polymerization of a bicyclic monomer, 3,4-ethylenedioxyth","[78.0, 910.0, 588.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -17,6,text,,"[600.0, 910.0, 1112.0, 1439.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +17,6,text,"exhibits a porous structure that is highly permeable to ions, +allowing the bulk volume to contribute to electrochemically +reactive areas. It also achieves high CSC and CIC without surface +roughening, ","[600.0, 910.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 17,7,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 17,8,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 18,0,header,Review Article,"[82.0, 48.0, 217.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 18,1,header,View Article Online,"[992.0, 19.0, 1107.0, 37.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -18,2,figure_title,Table 1 Recent and representative electroactive materials and their key features for ES applications,"[91.0, 741.0, 114.0, 1432.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 1 Recent and representative electroactive materials an""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +18,2,figure_title,Table 1 Recent and representative electroactive materials and their key features for ES applications,"[91.0, 741.0, 114.0, 1432.0]",table_caption,0.9,"[""table prefix matched: Table 1 Recent and representative electroactive materials an""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 18,3,header,Chem Soc Rev,"[976.0, 20.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 18,4,table,
TypesElectroactive constituentMaterial formulationElectrical propertiesMechanical propertiesOther key featuresBiomedical applicatio,"[125.0, 79.0, 1075.0, 1442.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 18,5,footer,Chem. Soc. Rev.,"[84.0, 1493.0, 203.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -285,20 +337,20 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 20,0,header,Review Article,"[82.0, 49.0, 217.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 20,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 20,2,header,Chem Soc Rev,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -20,3,figure_title,a,"[204.0, 107.0, 221.0, 124.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -20,4,image,,"[202.0, 103.0, 573.0, 392.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,5,figure_title,b,"[587.0, 105.0, 606.0, 123.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -20,6,image,,"[586.0, 104.0, 991.0, 389.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,7,image,,"[204.0, 402.0, 619.0, 762.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -20,8,image,,"[635.0, 399.0, 990.0, 763.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,9,figure_title,e,"[207.0, 777.0, 222.0, 794.0]",figure_caption_candidate,0.85,"[""figure_title label: e""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -20,10,image,,"[203.0, 776.0, 415.0, 974.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,11,chart,,"[430.0, 785.0, 712.0, 971.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,12,chart,,"[709.0, 785.0, 984.0, 971.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,13,image,,"[207.0, 999.0, 603.0, 1184.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,14,image,,"[607.0, 1012.0, 786.0, 1173.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,15,chart,,"[789.0, 1016.0, 985.0, 1177.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -20,16,figure_title,"Fig. 9 Electroactive materials. (a) Mixed ionic/electronic conduction in PEDOT:PSS. $ ^{272} $ Reproduced from ref. 272 with permission from Springer Nature, copyright 2016. (b) High-performance graph","[79.0, 1207.0, 1112.0, 1369.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 9 Electroactive materials. 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(a) Mixed ionic/electronic conduction in PEDOT:PSS. $ ^{272} $ Reproduced from ref. 272 with permission from Springer Nature, copyright 2016. (b) High-performance graph","[79.0, 1207.0, 1112.0, 1369.0]",figure_caption,0.92,"[""figure_title label: Fig. 9 Electroactive materials. (a) Mixed ionic/electronic c""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 20,17,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 203.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 20,18,footer,This journal is © The Royal Society of Chemistry 2024,"[711.0, 1494.0, 1108.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 21,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -306,7 +358,8 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 21,2,header,Review Article,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 21,3,text,"electrochemical properties. Their CIC reached 10.34 mC cm⁻² with an expanded CV window and a high signal-to-noise ratio, thus facilitating the measurement of neuronal activity. Such high CIC was achie","[78.0, 97.0, 588.0, 670.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,4,text,"MXenes, 2D transition metal carbide nanomaterials, have gained significant attention in recent years as highly promising materials for ES due to their good electrical conductivity ( $ \sim $1000 S cm ","[78.0, 670.0, 589.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -21,5,text,,"[600.0, 98.0, 1109.0, 144.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +21,5,text,"aqueous and organic solvents, making them feasible to fabricate +robust MXene-based thin-film electrodes for multiscale ES.294","[600.0, 98.0, 1109.0, 144.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,6,text,"BP is another conductive dopant that has attracted much scientific interest recently. $ ^{295} $ Due to its distinctive 2D planar structure (i.e., a bilayer arrangement along the zigzag direction and ","[600.0, 146.0, 1111.0, 359.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,7,text,"Apart from the abovementioned electroactive materials, hybrid conducive materials have also been proposed as the ES interfaces. For instance, it is possible to realize totally reversible non-faradaic ","[597.0, 360.0, 1112.0, 1366.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 21,8,text,"To summarize, these materials exhibit favorable electrical properties for ES through appropriate modification and processing. However, practical applications require consideration of","[600.0, 1366.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -319,7 +372,8 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 22,4,paragraph_title,4.2. Mechanical properties,"[80.0, 186.0, 314.0, 208.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2. Mechanical properties""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 22,5,text,"ES electrodes should have rigorous mechanical performances according to their specific applications. For example, as on-skin electrodes, they need to be soft and flexible to conformally contact the sk","[78.0, 217.0, 589.0, 671.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,6,text,"While the material composition of an ES electrode predominantly determines its mechanical properties, numerous studies have demonstrated that meticulous geometric design can effectively complement and","[78.0, 671.0, 589.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -22,7,text,,"[600.0, 98.0, 1109.0, 144.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +22,7,text,"where PPy is incorporated as the conductive component while silk +fibroin is for enhanced mechanical strength.102","[600.0, 98.0, 1109.0, 144.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,8,text,"However, these geometric designs as well as addition of different components with high mechanical performances solely enhanced the mechanical stretching of electrodes, yet they did not address the iss","[600.0, 143.0, 1112.0, 887.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,9,text,"It is worth mentioning that many studies have adopted finite element analysis to evaluate the distribution of interfacial mechanical strains, aiming to direct rational structural design. $ ^{310-312} ","[600.0, 887.0, 1111.0, 1031.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 22,10,paragraph_title,4.3. Adhesion performance,"[602.0, 1047.0, 839.0, 1069.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.3. Adhesion performance""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True @@ -329,34 +383,40 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 23,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 23,1,header,View Article Online,"[990.0, 19.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 23,2,header,Review Article,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -23,3,image,,"[174.0, 102.0, 1014.0, 662.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -23,4,chart,,"[794.0, 356.0, 1013.0, 502.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -23,5,chart,,"[797.0, 504.0, 1006.0, 658.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -23,6,figure_title,Fig. 10 Mechanical properties. (a) A multilayer Au/Cr-PI construction showing excellent stretchability and compressibility. $ ^{305} $ Reproduced from ref. 305 with permission from John Wiley and Sons,"[79.0, 674.0, 1108.0, 738.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 10 Mechanical properties. (a) A multilayer Au/Cr-PI con""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +23,3,image,,"[174.0, 102.0, 1014.0, 662.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +23,4,chart,,"[794.0, 356.0, 1013.0, 502.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,5,chart,,"[797.0, 504.0, 1006.0, 658.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,6,figure_title,Fig. 10 Mechanical properties. (a) A multilayer Au/Cr-PI construction showing excellent stretchability and compressibility. $ ^{305} $ Reproduced from ref. 305 with permission from John Wiley and Sons,"[79.0, 674.0, 1108.0, 738.0]",figure_caption,0.92,"[""figure_title label: Fig. 10 Mechanical properties. (a) A multilayer Au/Cr-PI con""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 23,7,text,"and chemical bonding, the integrated device could conformally contact and stably adhere to the dynamic heart. The adhesion energy to epicardium reached $ 240 \pm 20 \, J \, m^{-2} $. Combined with th","[78.0, 767.0, 588.0, 910.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,8,text,"The second strategy to enhance interfacial integration with tissues involves the fabrication of diverse microstructures on electrodes, taking inspiration from natural structures such as gecko feet, $ ","[78.0, 911.0, 588.0, 1388.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,9,text,"Another promising strategy involves the chemical modification of the substrates or electrodes to enhance their tackiness, typically forming pressure-sensitive adhesives. Similar to the abovementioned ","[79.0, 1389.0, 589.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -23,10,text,,"[600.0, 767.0, 1111.0, 1173.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +23,10,text,"typically forming pressure-sensitive adhesives. Similar to the +abovementioned microstructure-induced ‘‘dry adhesive’’, +pressure-sensitive adhesives do not rely on chemical bonding +for adhesion. Instea","[600.0, 767.0, 1111.0, 1173.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,11,text,"Controllable tissue adhesiveness is of paramount importance in the development of bioelectronic interfaces. $ ^{335} $ While strong adhesion is desirable during device use, it can potentially lead to ","[600.0, 1174.0, 1111.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 23,12,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 23,13,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 24,0,header,Review Article,"[82.0, 49.0, 217.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 24,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 24,2,header,Chem Soc Rev,"[973.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -24,3,image,,"[116.0, 110.0, 1075.0, 298.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -24,4,image,,"[116.0, 315.0, 603.0, 617.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -24,5,image,,"[651.0, 316.0, 937.0, 437.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -24,6,image,,"[942.0, 315.0, 1062.0, 435.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -24,7,image,,"[674.0, 449.0, 872.0, 613.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -24,8,image,,"[883.0, 452.0, 1057.0, 612.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -24,9,image,,"[118.0, 630.0, 458.0, 881.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -24,10,chart,,"[124.0, 897.0, 462.0, 1072.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -24,11,image,,"[479.0, 634.0, 1070.0, 1068.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -24,12,chart,,"[945.0, 896.0, 1064.0, 1052.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -24,13,figure_title,Fig. 11 Adhesion and biological properties. (a) (i) A photocurable hydrogel-based bioelectronic interface that (ii) could strongly bind to heart tissue and the electrode by complex physical and chemic,"[78.0, 1086.0, 1112.0, 1289.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 11 Adhesion and biological properties. (a) (i) A photoc""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +24,3,image,,"[116.0, 110.0, 1075.0, 298.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,4,image,,"[116.0, 315.0, 603.0, 617.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +24,5,image,,"[651.0, 316.0, 937.0, 437.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,6,image,,"[942.0, 315.0, 1062.0, 435.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,7,image,,"[674.0, 449.0, 872.0, 613.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,8,image,,"[883.0, 452.0, 1057.0, 612.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,9,image,,"[118.0, 630.0, 458.0, 881.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +24,10,chart,,"[124.0, 897.0, 462.0, 1072.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,11,image,,"[479.0, 634.0, 1070.0, 1068.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +24,12,chart,,"[945.0, 896.0, 1064.0, 1052.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,13,figure_title,Fig. 11 Adhesion and biological properties. (a) (i) A photocurable hydrogel-based bioelectronic interface that (ii) could strongly bind to heart tissue and the electrode by complex physical and chemic,"[78.0, 1086.0, 1112.0, 1289.0]",figure_caption,0.92,"[""figure_title label: Fig. 11 Adhesion and biological properties. (a) (i) A photoc""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 24,14,paragraph_title,4.4. Biosafety and biological functions,"[80.0, 1318.0, 408.0, 1339.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.4. Biosafety and biological functions""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 24,15,text,"Biosafety is a critical consideration for in vivo ES, which is determined by both stimulation parameters $ ^{340} $ and device components. $ ^{341} $ As mentioned in Section 3.2.2, ES with charge imba","[79.0, 1340.0, 588.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -24,16,text,,"[600.0, 1317.0, 1111.0, 1439.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +24,16,text,"uncontrollable current pulsing, and high access voltage have +been shown to induce various irreversible chemical +reactions.342 These reactions can locally disrupt the in vivo +microenvironment (e.g., in","[600.0, 1317.0, 1111.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 24,17,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 24,18,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 25,0,header,Chem Soc Rev,"[82.0, 49.0, 219.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -365,7 +425,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 25,3,text,"electrode and the adjacent tissue. To prevent excessive voltage that activates these electrochemical reactions and increase the selectivity of stimulation, Flavin et al. implemented a lower stimulatio","[78.0, 99.0, 588.0, 547.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 25,4,text,"The electrode material itself can also affect the compatibility with targeted tissues. For instance, the direct and prolonged exposure of metal film electrodes to the skin can potentially result in sk","[78.0, 552.0, 588.0, 886.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_side_zone,body_like,none,True,True 25,5,text,"To address these biosafety concerns, a feasible approach is to integrate multiple biological functionalities into the design of electrodes, which allows for active regulation of various biological pro","[78.0, 888.0, 589.0, 1441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -25,6,text,,"[600.0, 98.0, 1110.0, 241.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +25,6,text,"betaine), are also widely utilized to modify electrode surfaces to +form anti-biofouling interfaces.326,351 By integrating these intri- +guing biofunctions, the electrodes can mitigate potential risks +a","[600.0, 98.0, 1110.0, 241.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 25,7,paragraph_title,4.5. Biodegradable/bioresorbable properties,"[602.0, 257.0, 973.0, 280.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.5. Biodegradable/bioresorbable properties""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 25,8,text,"Traditional implanted ES devices require surgical removal after accomplishing their therapeutic purpose. However, secondary removal surgery not only adds an additional financial burden but also carrie","[600.0, 289.0, 1111.0, 503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 25,9,text,The in vivo degradation of bioresorbable polymers involves several representative mechanisms that are of considerable importance in the controlled dissolution within the biological environment. These ,"[600.0, 504.0, 1111.0, 959.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -376,12 +439,15 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 26,1,header,View Article Online,"[991.0, 19.0, 1108.0, 37.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 26,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 26,3,text,"oxidative reaction, can be used for circuits and electrodes. In addition, silicone (Si) can also serve as a viable material choice for bioresorbable devices, as it undergoes hydrolysis to silicic acid","[78.0, 97.0, 589.0, 483.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -26,4,text,,"[601.0, 97.0, 1111.0, 239.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +26,4,text,"attaching onto the mechanically dynamic heart surface, while +concurrently minimizing any discernible deviations in output +voltage during mechanical deformation. In vivo experiments +demonstrated that t","[601.0, 97.0, 1111.0, 239.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 26,5,text,"To fulfill the demands of practical applications, the degradation rate of ES devices can be finely tailored by various strategies including the change in encapsulating layer thickness and modulation o","[600.0, 240.0, 1112.0, 482.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -26,6,image,,"[175.0, 543.0, 1012.0, 1300.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -26,7,chart,,"[526.0, 875.0, 771.0, 1075.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -26,8,chart,,"[773.0, 880.0, 994.0, 1070.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -26,9,figure_title,"Fig. 12 Biodegradable properties. (a) Schematic illustrations showing the representative in vivo degradation mechanisms of bioresorbable polymers, including (i) dissolution, (ii) enzymolysis, (iii) hy","[80.0, 1314.0, 1111.0, 1436.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 12 Biodegradable properties. (a) Schematic illustration""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +26,6,image,,"[175.0, 543.0, 1012.0, 1300.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +26,7,chart,,"[526.0, 875.0, 771.0, 1075.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +26,8,chart,,"[773.0, 880.0, 994.0, 1070.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +26,9,figure_title,"Fig. 12 Biodegradable properties. (a) Schematic illustrations showing the representative in vivo degradation mechanisms of bioresorbable polymers, including (i) dissolution, (ii) enzymolysis, (iii) hy","[80.0, 1314.0, 1111.0, 1436.0]",figure_caption,0.92,"[""figure_title label: Fig. 12 Biodegradable properties. (a) Schematic illustration""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 26,10,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 26,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 27,0,header,Chem Soc Rev,"[82.0, 49.0, 219.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -391,7 +457,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 27,4,paragraph_title,4.6. Other key properties,"[80.0, 329.0, 300.0, 352.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.6. Other key properties""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 27,5,text,"Breathability assumes a paramount role for development of bioelectronic devices, particularly for on-skin bioelectronics, as the water vapor and sweat easily accumulate at the skin-device interfaces t","[78.0, 361.0, 588.0, 717.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 27,6,text,"Over recent years, the utilization of electrospun fibers for preparation of ultrathin breathable bioelectronics with a porous structure akin to fabric or textiles has garnered growing interest. $ ^{35","[78.0, 720.0, 589.0, 1441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -27,7,text,,"[600.0, 97.0, 1112.0, 503.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +27,7,text,"thereby safeguarding the normal operation of the devices.362 It +should be emphasized that these breathable designs are highly +suitable for electrodes, energy harvesters/storage, and/or sensors; +howeve","[600.0, 97.0, 1112.0, 503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 27,8,text,"In addition to breathability, the controllable swellability of bioelectronic interfaces has also been instrumental for their performances, especially in the case of hydrogel-based bioelectronic interf","[600.0, 504.0, 1111.0, 909.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 27,9,text,"Stimuli-responsiveness represents a highly desirable and intriguing characteristic of many intelligent systems such as drug delivery platforms. $ ^{367} $ In the specific context of ES systems, this c","[600.0, 911.0, 1112.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 27,10,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -400,14 +469,17 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 28,1,header,View Article Online,"[991.0, 19.0, 1108.0, 37.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 28,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 28,3,text,films were fabricated using a combination of poly(ethylene oxide) (PEO) and poly(ethylene glycol)-α-cyclodextrin inclusion complex. These films were specifically designed to possess aligned microporou,"[78.0, 96.0, 589.0, 338.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -28,4,text,,"[600.0, 97.0, 1112.0, 339.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True -28,5,figure_title,a,"[171.0, 399.0, 191.0, 421.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -28,6,image,,"[166.0, 395.0, 1027.0, 1112.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -28,7,figure_title,b,"[171.0, 758.0, 191.0, 782.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -28,8,chart,,"[318.0, 927.0, 439.0, 1100.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -28,9,chart,,"[624.0, 921.0, 789.0, 1095.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -28,10,image,,"[167.0, 1117.0, 1023.0, 1300.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -28,11,figure_title,Fig. 13 Other key properties. (a) (i) A highly integrated breathable bioelectronic that (ii) could transport sweat via vertical and horizontal directions. $ ^{364} $ Reproduced from ref. 364 with perm,"[80.0, 1314.0, 1111.0, 1435.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 13 Other key properties. (a) (i) A highly integrated br""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +28,4,text,"involved the utilization of inclusion complex platelets that +facilitated the permanent crosslinking of the isotropic semi- +crystalline domains of PEO through the formation of hydrogen +bonds. During th","[600.0, 97.0, 1112.0, 339.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,5,figure_title,a,"[171.0, 399.0, 191.0, 421.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +28,6,image,,"[166.0, 395.0, 1027.0, 1112.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +28,7,figure_title,b,"[171.0, 758.0, 191.0, 782.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +28,8,chart,,"[318.0, 927.0, 439.0, 1100.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +28,9,chart,,"[624.0, 921.0, 789.0, 1095.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +28,10,image,,"[167.0, 1117.0, 1023.0, 1300.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +28,11,figure_title,Fig. 13 Other key properties. (a) (i) A highly integrated breathable bioelectronic that (ii) could transport sweat via vertical and horizontal directions. $ ^{364} $ Reproduced from ref. 364 with perm,"[80.0, 1314.0, 1111.0, 1435.0]",figure_caption,0.92,"[""figure_title label: Fig. 13 Other key properties. (a) (i) A highly integrated br""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 28,12,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 28,13,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 29,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -419,7 +491,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 29,6,text,"Tissue engineering is a multidisciplinary field that merges biology with engineering to develop functional substitutes for damaged tissues, striving to match the structure and function of healthy in v","[78.0, 570.0, 588.0, 887.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 29,7,paragraph_title,5.1. Skin healing,"[80.0, 903.0, 236.0, 925.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1. Skin healing""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 29,8,text,"Skin, as the largest organ in the human body, serves a crucial function in safeguarding internal tissues and organs against infections and injuries. However, it also presents significant risks of dama","[78.0, 934.0, 588.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -29,9,text,,"[600.0, 99.0, 1111.0, 455.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +29,9,text,"Decades ago, the theory of skin battery and the relationship +between skin wounds and endogenous electrical signals were +proposed by Barker388 and Ghadamali,389 respectively. They +believed that the ele","[600.0, 99.0, 1111.0, 455.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 29,10,text,"According to the differences in current models, commonly used ES methods can be categorized as either the unidirectional current (or voltage) or bidirectional current (or voltage) stimulation method. ","[600.0, 457.0, 1111.0, 839.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 29,11,text,"Both unidirectional and bidirectional currents have similar effects on wound healing; the working modes are largely determined by the selection of power sources for these generators, especially for th","[599.0, 838.0, 1112.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 29,12,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -427,17 +502,17 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 30,0,header,Review Article,"[82.0, 49.0, 218.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 30,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 30,2,header,Chem Soc Rev,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -30,3,image,,"[177.0, 104.0, 599.0, 300.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,4,image,,"[620.0, 109.0, 1013.0, 300.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,5,image,,"[184.0, 308.0, 505.0, 504.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,6,image,,"[512.0, 307.0, 669.0, 498.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,7,image,,"[688.0, 307.0, 1012.0, 503.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,8,image,,"[177.0, 511.0, 619.0, 715.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -30,9,image,,"[641.0, 512.0, 1011.0, 767.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,10,image,,"[177.0, 721.0, 629.0, 976.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -30,11,image,,"[654.0, 798.0, 988.0, 956.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,12,image,,"[176.0, 987.0, 1014.0, 1209.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -30,13,figure_title,"Fig. 14 ES for skin healing. (a) ES waveforms of unidirectional current (charge-unbalanced) and bidirectional current. $ ^{381} $ Reproduced from ref. 381 with permission from John Wiley and Sons, cop","[78.0, 1220.0, 1112.0, 1402.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 14 ES for skin healing. (a) ES waveforms of unidirectio""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +30,3,image,,"[177.0, 104.0, 599.0, 300.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,4,image,,"[620.0, 109.0, 1013.0, 300.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,5,image,,"[184.0, 308.0, 505.0, 504.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,6,image,,"[512.0, 307.0, 669.0, 498.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,7,image,,"[688.0, 307.0, 1012.0, 503.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,8,image,,"[177.0, 511.0, 619.0, 715.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +30,9,image,,"[641.0, 512.0, 1011.0, 767.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,10,image,,"[177.0, 721.0, 629.0, 976.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +30,11,image,,"[654.0, 798.0, 988.0, 956.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,12,image,,"[176.0, 987.0, 1014.0, 1209.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,13,figure_title,"Fig. 14 ES for skin healing. (a) ES waveforms of unidirectional current (charge-unbalanced) and bidirectional current. $ ^{381} $ Reproduced from ref. 381 with permission from John Wiley and Sons, cop","[78.0, 1220.0, 1112.0, 1402.0]",figure_caption,0.92,"[""figure_title label: Fig. 14 ES for skin healing. (a) ES waveforms of unidirectio""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 30,14,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 203.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 30,15,footer,This journal is © The Royal Society of Chemistry 2024,"[711.0, 1494.0, 1108.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 31,0,header,Chem Soc Rev,"[82.0, 49.0, 219.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -456,7 +531,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 32,4,paragraph_title,5.2. Muscle regeneration,"[80.0, 187.0, 298.0, 208.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2. Muscle regeneration""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 32,5,text,"Muscle tissues are essential elements of an organism, making up more than 50% of body mass and playing key roles in generating force, facilitating body movement, and supporting the operation of intern","[78.0, 219.0, 589.0, 958.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 32,6,text,"Conductive biomaterials have shown promise in enhancing the proliferation and differentiation of cells that are sensitive to electrical stimuli. $ ^{44,407,422} $ These materials are excellent candida","[78.0, 958.0, 589.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -32,7,text,,"[600.0, 98.0, 1111.0, 480.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +32,7,text,"recently, because they can be effectively delivered to inaccessible +sites for tissue regeneration.424 Jin et al. developed an electro- +active, biocompatible and injectable hydrogel, based on +phenylbora","[600.0, 98.0, 1111.0, 480.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 32,8,text,"In addition to materials that directly interface with muscle tissues to influence the electrical microenvironments around muscle injuries and transmit ES to target areas, bioelectronics with more func","[599.0, 478.0, 1113.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 32,9,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 32,10,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -465,9 +543,12 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 33,2,header,Review Article,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 33,3,text,"that are programmed to emit bionic spikes. This approach led to a significant 73.5% reduction in the inflammatory cytokine IL-6, showcasing its potent anti-inflammatory effects in tendon regeneration.","[78.0, 97.0, 587.0, 191.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 33,4,text,"The heart circulates blood through the whole body via the contraction of cardiac muscles. Unfortunately, cardiac muscle tissue has limited regeneration ability after injury, often leading to the repla","[78.0, 193.0, 589.0, 338.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -33,5,text,,"[600.0, 97.0, 1112.0, 338.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True -33,6,image,,"[116.0, 376.0, 1077.0, 1206.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -33,7,figure_title,Fig. 15 ES for muscle regeneration. (a) Injecting the hydrogel into the damaged muscle improved the tissue repair process (left). In vivo muscle-tissue conduction in the severe tissue defect model. Sc,"[78.0, 1216.0, 1112.0, 1435.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 15 ES for muscle regeneration. (a) Injecting the hydrog""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +33,5,text,"explored an innovative approach that involves incorporating Au +nanowires (AuNWs) into alginate scaffolds to electrically +enhance communication between cardiac cells in engineered +cardiac patches (Fig. ","[600.0, 97.0, 1112.0, 338.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +33,6,image,,"[116.0, 376.0, 1077.0, 1206.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +33,7,figure_title,Fig. 15 ES for muscle regeneration. (a) Injecting the hydrogel into the damaged muscle improved the tissue repair process (left). In vivo muscle-tissue conduction in the severe tissue defect model. Sc,"[78.0, 1216.0, 1112.0, 1435.0]",figure_caption,0.92,"[""figure_title label: Fig. 15 ES for muscle regeneration. (a) Injecting the hydrog""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 33,8,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 33,9,footer,Chem. Soc. Rev.,"[986.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 34,0,header,Review Article,"[81.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -477,17 +558,22 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 34,4,paragraph_title,5.3. Bone regeneration,"[80.0, 329.0, 283.0, 351.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3. Bone regeneration""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 34,5,text,"Bone regeneration is the process of repairing or regenerating damaged or diseased bone tissues, which are the main structural and supportive components of the human body. As one of the few tissues in ","[78.0, 361.0, 588.0, 838.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 34,6,text,"Similar to the in vitro stimulation platforms, according to the differences in power sources, the electrostimulators for bone regeneration could be divided into the invasive DC ESs and non-invasive st","[78.0, 841.0, 589.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -34,7,text,,"[600.0, 98.0, 1110.0, 264.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +34,7,text,"also known as capacitive electrodes or plates, to be situated on +the skin flanking the target area. The integrated power resource +produces either a stable or fluctuating electrical field within +the ta","[600.0, 98.0, 1110.0, 264.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 34,8,text,"For bone ES, the selection of power sources is still a matter that requires significant attention, especially for the implanted stimulators. In addition to the commonly used commercial batteries, ther","[598.0, 263.0, 1113.0, 1441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 34,9,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 34,10,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 35,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 35,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 35,2,header,Review Article,"[973.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -35,3,image,,"[174.0, 103.0, 1016.0, 1151.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -35,4,figure_title,"Fig. 16 ES for bone regeneration. (a) Classification of ES based bone growth by the mechanism of operation and electrical energy delivery $ ^{427} $ Reproduced from ref. 427 with permission from IEEE,","[79.0, 1170.0, 1111.0, 1311.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 16 ES for bone regeneration. (a) Classification of ES b""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +35,3,image,,"[174.0, 103.0, 1016.0, 1151.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +35,4,figure_title,"Fig. 16 ES for bone regeneration. (a) Classification of ES based bone growth by the mechanism of operation and electrical energy delivery $ ^{427} $ Reproduced from ref. 427 with permission from IEEE,","[79.0, 1170.0, 1111.0, 1311.0]",figure_caption,0.92,"[""figure_title label: Fig. 16 ES for bone regeneration. (a) Classification of ES b""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 35,5,text,"electro-inspired bone tissue regeneration (Fig. 16d). $ ^{437} $ Exhibiting superior electroactivity, biocompatibility, and osteoinductivity, the CPM@MA hydrogel notably augmented cellular functionali","[79.0, 1364.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -35,6,text,,"[600.0, 1365.0, 1111.0, 1438.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +35,6,text,"This was accomplished through the upregulation of endogenous +transforming growth factor-beta1 (TGF-b1) and the activation of +the associated TGF-b/Smad2 signaling pathway. The hydrogel,","[600.0, 1365.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 35,7,footer,This journal is © The Royal Society of Chemistry 2024,"[83.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 35,8,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 36,0,header,Review Article,"[81.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -497,7 +583,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 36,4,paragraph_title,5.4. Nerve regeneration,"[80.0, 737.0, 287.0, 758.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.4. Nerve regeneration""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 36,5,text,"Nerve injuries can cause extensive motor, sensory, and autonomic dysfunctions, severely impacting daily and professional activities. $ ^{439-441} $ The nervous system possesses regenerative capabiliti","[78.0, 768.0, 588.0, 1269.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 36,6,text,"Optimal nerve recovery is often hindered by factors such as chronic axotomy, chronic denervation, and slow axonal growth at surgical sites. Research has shown that low-frequency (20 Hz) ES applied aft","[78.0, 1269.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -36,7,text,,"[600.0, 98.0, 1111.0, 480.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +36,7,text,"the regenerative effects of ES include the promotion of axonal +growth through cyclic adenosine monophosphate (cAMP), +enhancement by neurotrophic factors, and the involvement of +Schwann cells (Fig. 17a)","[600.0, 98.0, 1111.0, 480.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 36,8,text,"In clinical practice, a variety of advanced strategies, including precise nerve repair surgeries and pioneering bioengineering approaches like nerve guidance conduits, are employed to enhance peripher","[600.0, 480.0, 1111.0, 981.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 36,9,text,"NGCs are used in combination with ES to treat neural injury, providing physical support and directional guidance while enhancing nerve growth and functional recovery through ES. This combination thera","[600.0, 984.0, 1111.0, 1293.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 36,10,text,"Cumbersome external percutaneous wiring is an important issue for implantable ES devices because it can lead to infection risks, local discomfort, activity restrictions, and maintenance difficulties. ","[600.0, 1294.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -506,18 +595,21 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 37,0,header,Chem Soc Rev,"[82.0, 50.0, 218.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 37,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 37,2,header,Review Article,"[973.0, 50.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -37,3,image,,"[139.0, 103.0, 497.0, 293.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -37,4,chart,,"[502.0, 118.0, 778.0, 287.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -37,5,chart,,"[772.0, 112.0, 1051.0, 289.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -37,6,image,,"[140.0, 307.0, 623.0, 565.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -37,7,image,,"[635.0, 311.0, 1043.0, 431.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -37,8,image,,"[633.0, 445.0, 1050.0, 562.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -37,9,image,,"[140.0, 575.0, 552.0, 721.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -37,10,image,,"[140.0, 732.0, 554.0, 890.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -37,11,image,,"[558.0, 577.0, 1046.0, 889.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -37,12,figure_title,"Fig. 17 ES for nerve regeneration. (a) Neurons and Schwann cells transition into a growth state, where motoneurons display chromatolytic changes such as the nucleus shifting to an eccentric position, ","[78.0, 906.0, 1112.0, 1208.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 17 ES for nerve regeneration. (a) Neurons and Schwann c""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +37,3,image,,"[139.0, 103.0, 497.0, 293.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,4,chart,,"[502.0, 118.0, 778.0, 287.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,5,chart,,"[772.0, 112.0, 1051.0, 289.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,6,image,,"[140.0, 307.0, 623.0, 565.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +37,7,image,,"[635.0, 311.0, 1043.0, 431.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,8,image,,"[633.0, 445.0, 1050.0, 562.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,9,image,,"[140.0, 575.0, 552.0, 721.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +37,10,image,,"[140.0, 732.0, 554.0, 890.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +37,11,image,,"[558.0, 577.0, 1046.0, 889.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,12,figure_title,"Fig. 17 ES for nerve regeneration. (a) Neurons and Schwann cells transition into a growth state, where motoneurons display chromatolytic changes such as the nucleus shifting to an eccentric position, ","[78.0, 906.0, 1112.0, 1208.0]",figure_caption,0.92,"[""figure_title label: Fig. 17 ES for nerve regeneration. (a) Neurons and Schwann c""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 37,13,text,"circumvent these issues. Generating ES based on the piezoelectric effect of the device itself is a novel method. $ ^{452,479-481} $ Wu et al. reported a self-powered piezoelectric polymer scaffold emb","[78.0, 1245.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -37,14,text,,"[600.0, 1243.0, 1111.0, 1437.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +37,14,text,"Implantation of the device improved neurological deficits in +mouse models under the stimulation of running. Expanding +upon self-powered solutions, devices based on triboelectric +nanogenerators482 or h","[600.0, 1243.0, 1111.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 37,15,footer,This journal is © The Royal Society of Chemistry 2024,"[83.0, 1494.0, 479.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 37,16,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1106.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 38,0,header,Review Article,"[81.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -525,7 +617,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 38,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 72.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 38,3,text,"yielded therapeutic outcomes for long-segment peripheral nerve injuries (15 mm defect) that were on par with those from autologous nerve grafts (Fig. 17b). $ ^{449} $ Moreover, tubular zinc-oxygen (Zn","[78.0, 97.0, 589.0, 813.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 38,4,text,"The necessity of secondary surgical interventions for the extraction of implantable devices represents a significant limitation, often resulting in patient discomfort, pain, and potential complication","[78.0, 814.0, 589.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -38,5,text,,"[599.0, 97.0, 1111.0, 527.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +38,5,text,"strategy involves the utilization of battery-free electrical stimu- +lators, which are powered by external RF energy.378,486 Such +devices are fabricated using bioresorbable materials, including +Mg, Mo,","[599.0, 97.0, 1111.0, 527.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 38,6,paragraph_title,5.5. Drug delivery,"[602.0, 544.0, 765.0, 567.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.5. Drug delivery""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 38,7,text,"The field of drug delivery has experienced significant advancements, with the emergence of electric fields as a promising technique with diverse therapeutic applications. $ ^{489} $ Such applications ","[600.0, 575.0, 1111.0, 934.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 38,8,text,5.5.1. Iontophoresis. Iontophoresis enables the transportation of small molecules across the skin layer known as the stratum corneum via electrophoresis and electroosmosis at low-voltage (typically <1,"[599.0, 936.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True @@ -534,23 +629,23 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 39,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 39,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 39,2,header,Review Article,"[973.0, 49.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -39,3,figure_title,a,"[207.0, 110.0, 223.0, 124.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -39,4,image,,"[204.0, 105.0, 518.0, 387.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,5,figure_title,b,"[525.0, 108.0, 540.0, 124.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -39,6,image,,"[524.0, 106.0, 991.0, 386.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,7,image,,"[204.0, 392.0, 490.0, 600.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -39,8,image,,"[497.0, 396.0, 991.0, 602.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -39,9,image,,"[204.0, 606.0, 462.0, 805.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -39,10,image,,"[462.0, 611.0, 758.0, 800.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -39,11,image,,"[764.0, 609.0, 992.0, 799.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,12,chart,,"[205.0, 812.0, 421.0, 907.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,13,image,,"[430.0, 817.0, 575.0, 907.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,14,image,,"[212.0, 925.0, 392.0, 1033.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,15,image,,"[420.0, 916.0, 590.0, 1039.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,16,image,,"[601.0, 814.0, 991.0, 950.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,17,image,,"[205.0, 1040.0, 589.0, 1183.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,18,image,,"[601.0, 965.0, 989.0, 1179.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -39,19,figure_title,Fig. 18 ES for drug delivery by iontophoresis. (a) The working principle of iontophoresis involves using a low electrical current to transport charged molecules on the skin's surface. $ ^{490} $ Repro,"[79.0, 1195.0, 1111.0, 1434.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 18 ES for drug delivery by iontophoresis. (a) The worki""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +39,3,figure_title,a,"[207.0, 110.0, 223.0, 124.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,4,image,,"[204.0, 105.0, 518.0, 387.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,5,figure_title,b,"[525.0, 108.0, 540.0, 124.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,6,image,,"[524.0, 106.0, 991.0, 386.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,7,image,,"[204.0, 392.0, 490.0, 600.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,8,image,,"[497.0, 396.0, 991.0, 602.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,9,image,,"[204.0, 606.0, 462.0, 805.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,10,image,,"[462.0, 611.0, 758.0, 800.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,11,image,,"[764.0, 609.0, 992.0, 799.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,12,chart,,"[205.0, 812.0, 421.0, 907.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,13,image,,"[430.0, 817.0, 575.0, 907.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,14,image,,"[212.0, 925.0, 392.0, 1033.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,15,image,,"[420.0, 916.0, 590.0, 1039.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,16,image,,"[601.0, 814.0, 991.0, 950.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,17,image,,"[205.0, 1040.0, 589.0, 1183.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,18,image,,"[601.0, 965.0, 989.0, 1179.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,19,figure_title,Fig. 18 ES for drug delivery by iontophoresis. (a) The working principle of iontophoresis involves using a low electrical current to transport charged molecules on the skin's surface. $ ^{490} $ Repro,"[79.0, 1195.0, 1111.0, 1434.0]",figure_caption,0.92,"[""figure_title label: Fig. 18 ES for drug delivery by iontophoresis. (a) The worki""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 39,20,footer,This journal is © The Royal Society of Chemistry 2024,"[83.0, 1494.0, 480.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 39,21,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 40,0,header,Review Article,"[81.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -558,7 +653,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 40,2,header,Chem Soc Rev,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 40,3,text,"wound, the skin temperature increased while the resistance of the thermal resistor would decrease. As a result, the voltage on SDICH would increase and thus more antibiotics were released by iontophor","[78.0, 96.0, 589.0, 1031.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 40,4,text,"Subsequently, the same group applied a PENG based controllable transdermal drug delivery system for treating psoriasis. $ ^{501} $ In this study, to counter the low drug penetration resulting from ski","[78.0, 1031.0, 588.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -40,5,text,,"[600.0, 98.0, 1111.0, 480.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +40,5,text,"efficiency of transdermal molecular penetration and extraction +using the MN array, as well as the potential for powering the +system with EBFCs. The results showed that the PMN was able +to lower the tran","[600.0, 98.0, 1111.0, 480.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 40,6,text,"Furthermore, integrated closed-loop feedback systems, which combine the strengths of sensor technologies and iontophoresis-based drug delivery techniques, have emerged as a promising strategy for adva","[600.0, 480.0, 1112.0, 1389.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 40,7,text,5.5.2. Electroporation. Electroporation has been one of the most commonly used strategies for non-viral drug or gene,"[601.0, 1390.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True 40,8,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -568,7 +666,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 41,2,header,Review Article,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 41,3,text,"delivery by applying high-voltage electrical pulses, which can create temporary pores or channels in the cell membrane. Electroporation can be used for various purposes, such as gene therapy, cell rep","[78.0, 95.0, 589.0, 1104.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 41,4,text,"As shown in Fig. 19c, high-voltage pulses were applied on the skin with pulse width on the order of microseconds to milliseconds, and a dielectric breakdown at the stratum corneum subsequently punctur","[77.0, 1102.0, 589.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -41,5,text,,"[600.0, 98.0, 1111.0, 360.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +41,5,text,"and notable stretchability was developed, comprising compo- +nents such as carbon black, graphene, silicone oil, kerosene, +and a Pt catalyst. Notably, the silicone oil additive in the +conductive ink pl","[600.0, 98.0, 1111.0, 360.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 41,6,text,"To further break through the skin barrier for drug delivery, MNs have been combined with the electroporation technology, which can largely improve delivery efficiency of large molecules and decrease t","[599.0, 359.0, 1112.0, 1223.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 41,7,paragraph_title,6. ES based bioelectronics for neuromodulation,"[601.0, 1261.0, 1000.0, 1325.0]",section_heading,0.85,"[""paragraph_title label with numbering: 6. ES based bioelectronics for neuromodulation""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True 41,8,text,"Neuromodulation via ES is a promising medical technique that activates, suppresses, or modifies nerve activity with electrical impulses. $ ^{8,510} $ This approach offers hope to patients with a range","[599.0, 1341.0, 1111.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -577,13 +678,13 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 42,0,header,Review Article,"[82.0, 49.0, 217.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 42,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 42,2,header,Chem Soc Rev,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -42,3,image,,"[223.0, 101.0, 549.0, 506.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -42,4,figure_title,b,"[565.0, 112.0, 585.0, 133.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -42,5,image,,"[564.0, 106.0, 966.0, 328.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -42,6,image,,"[561.0, 328.0, 965.0, 507.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -42,7,image,,"[224.0, 517.0, 963.0, 887.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -42,8,image,,"[225.0, 898.0, 969.0, 1138.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -42,9,figure_title,Fig. 19 ES for electroporation. (a) Schematic of a bulk electroporation system. The gap between the electrodes exceeds the size of a single cell by multiple orders of magnitude. $ ^{505} $ Reproduced ,"[79.0, 1151.0, 1112.0, 1370.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 19 ES for electroporation. (a) Schematic of a bulk elec""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +42,3,image,,"[223.0, 101.0, 549.0, 506.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,4,figure_title,b,"[565.0, 112.0, 585.0, 133.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +42,5,image,,"[564.0, 106.0, 966.0, 328.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,6,image,,"[561.0, 328.0, 965.0, 507.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,7,image,,"[224.0, 517.0, 963.0, 887.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +42,8,image,,"[225.0, 898.0, 969.0, 1138.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,9,figure_title,Fig. 19 ES for electroporation. (a) Schematic of a bulk electroporation system. The gap between the electrodes exceeds the size of a single cell by multiple orders of magnitude. $ ^{505} $ Reproduced ,"[79.0, 1151.0, 1112.0, 1370.0]",figure_caption,0.92,"[""figure_title label: Fig. 19 ES for electroporation. (a) Schematic of a bulk elec""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 42,10,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 42,11,footer,This journal is © The Royal Society of Chemistry 2024,"[711.0, 1494.0, 1108.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 43,0,header,Chem Soc Rev,"[82.0, 49.0, 219.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -592,7 +693,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 43,3,text,"targeted ES of nerves or specific brain regions, neuromodulation can influence neural circuits, conducive to symptom alleviation and functional restoration. $ ^{512-514} $ Brain stimulation encompasse","[78.0, 96.0, 589.0, 982.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 43,4,paragraph_title,6.1. Mechanisms of ES for neuromodulation,"[79.0, 1000.0, 457.0, 1021.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.1. Mechanisms of ES for neuromodulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 43,5,text,"The nervous system comprises numerous neurons, which are the essential units for transmitting excitatory and inhibitory signals. $ ^{536} $ Neurons are composed of several parts: the cell body (soma),","[78.0, 1031.0, 588.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -43,6,text,,"[600.0, 98.0, 1110.0, 408.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +43,6,text,"ES can directly impact and modulate neural activities, either +exciting or inhibiting the neuron.539,540 Likewise, when externally +applied voltage surpasses the threshold level (rheobase), it triggers +","[600.0, 98.0, 1110.0, 408.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 43,7,text,"To understand how to effectively excite a neuron, researchers have developed mathematical models to quantitatively describe neuronal electrical characteristics. One model is the spatially extended non","[599.0, 409.0, 1111.0, 814.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 43,8,text,"From F. Rattay's computational results, the electrical signal propagation along the neuron could be intuitively visualized, where the electrical impulse (duration: 0.1 ms) is generated from both insid","[599.0, 816.0, 1112.0, 1439.0]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,citation_line,True,True 43,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -600,21 +704,24 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 44,0,header,Review Article,"[82.0, 50.0, 217.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 44,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 44,2,header,Chem Soc Rev,"[972.0, 50.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -44,3,figure_title,a,"[148.0, 103.0, 165.0, 121.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -44,4,image,,"[148.0, 104.0, 748.0, 325.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +44,3,figure_title,a,"[148.0, 103.0, 165.0, 121.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +44,4,image,,"[148.0, 104.0, 748.0, 325.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True 44,5,figure_title,C,"[737.0, 103.0, 753.0, 122.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True -44,6,chart,,"[752.0, 105.0, 1023.0, 324.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -44,7,figure_title,d,"[148.0, 337.0, 167.0, 358.0]",figure_caption_candidate,0.85,"[""figure_title label: d""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False -44,8,figure_title,e,"[463.0, 340.0, 481.0, 358.0]",figure_caption_candidate,0.85,"[""figure_title label: e""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False -44,9,image,,"[136.0, 368.0, 452.0, 590.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -44,10,chart,,"[475.0, 364.0, 723.0, 609.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True -44,11,chart,,"[741.0, 338.0, 1052.0, 607.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -44,12,figure_title,Fig. 20 Mechanism of ES on a neuron. (a) Schematic illustration of efferent neurons (left) and afferent (right) neurons and the flows of excitation. $ ^{4} $ (b) Representation and equivalent circuit ,"[79.0, 617.0, 1107.0, 740.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 20 Mechanism of ES on a neuron. (a) Schematic illustrat""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +44,6,chart,,"[752.0, 105.0, 1023.0, 324.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +44,7,figure_title,d,"[148.0, 337.0, 167.0, 358.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +44,8,figure_title,e,"[463.0, 340.0, 481.0, 358.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +44,9,image,,"[136.0, 368.0, 452.0, 590.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +44,10,chart,,"[475.0, 364.0, 723.0, 609.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +44,11,chart,,"[741.0, 338.0, 1052.0, 607.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +44,12,figure_title,Fig. 20 Mechanism of ES on a neuron. (a) Schematic illustration of efferent neurons (left) and afferent (right) neurons and the flows of excitation. $ ^{4} $ (b) Representation and equivalent circuit ,"[79.0, 617.0, 1107.0, 740.0]",figure_caption,0.92,"[""figure_title label: Fig. 20 Mechanism of ES on a neuron. (a) Schematic illustrat""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 44,13,text,"show the $ V_n $ at the next three nodes, where a spike propagating velocity of $ \sim43 $ m s $ ^{-1} $ along the axon could be deduced.","[78.0, 791.0, 587.0, 837.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 44,14,text,"The concept of threshold rheobase is intricately linked to the duration of stimulation, a relationship known as the strength–duration curve (SD curve). $ ^{542} $ Using the SENN model to simulate resp","[79.0, 839.0, 588.0, 1318.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 44,15,paragraph_title,6.2. Electrical brain stimulation,"[79.0, 1334.0, 355.0, 1355.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.2. Electrical brain stimulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 44,16,text,"Electrical brain stimulation represents a cutting-edge approach for both therapeutic intervention and neurological research. $ ^{3,512,517} $ By administering precise electrical currents to designated","[79.0, 1366.0, 587.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -44,17,text,,"[601.0, 791.0, 1110.0, 909.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +44,17,text,"regions, this technique can modulate neuronal activity, potentially +restoring or augmenting neural functions disrupted by +conditions.543 ES of the brain can modulate sensory processing, +modulating sen","[601.0, 791.0, 1110.0, 909.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 44,18,text,"6.2.1. Deep brain stimulation. DBS exerts its influence on neurotransmitter release and synaptic plasticity through a complex mechanism. $ ^{520,545,546} $ A crucial feature is that by directly suppre","[600.0, 912.0, 1111.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True 44,19,text,"The outcomes of stimulating various brain areas can differ markedly. For example, targeting the area that includes the dorsal subthalamic nucleus (STN) and zona incerta (ZI) has been associated with r","[600.0, 1247.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 44,20,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 203.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -622,16 +729,17 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 45,0,header,Chem Soc Rev,"[82.0, 50.0, 218.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 45,1,header,View Article Online,"[991.0, 20.0, 1108.0, 35.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 45,2,header,Review Article,"[973.0, 49.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -45,3,image,,"[141.0, 101.0, 390.0, 364.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -45,4,image,,"[390.0, 102.0, 641.0, 365.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,3,image,,"[141.0, 101.0, 390.0, 364.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,4,image,,"[390.0, 102.0, 641.0, 365.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 45,5,table,,"[648.0, 104.0, 1047.0, 367.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,unknown_like,none,True,True -45,6,image,,"[141.0, 377.0, 598.0, 585.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -45,7,image,,"[609.0, 375.0, 1052.0, 583.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -45,8,image,,"[139.0, 597.0, 626.0, 797.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -45,9,image,,"[632.0, 601.0, 1052.0, 793.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -45,10,figure_title,"Fig. 21 Deep brain stimulation (DBS). (a) Mechanisms of DBS. Stimulation induces the release of neurotransmitters, initiating calcium waves and the subsequent release of gliotransmitters, with DBS alt","[78.0, 807.0, 1113.0, 1088.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 21 Deep brain stimulation (DBS). (a) Mechanisms of DBS.""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +45,6,image,,"[141.0, 377.0, 598.0, 585.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +45,7,image,,"[609.0, 375.0, 1052.0, 583.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,8,image,,"[139.0, 597.0, 626.0, 797.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +45,9,image,,"[632.0, 601.0, 1052.0, 793.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,10,figure_title,"Fig. 21 Deep brain stimulation (DBS). (a) Mechanisms of DBS. Stimulation induces the release of neurotransmitters, initiating calcium waves and the subsequent release of gliotransmitters, with DBS alt","[78.0, 807.0, 1113.0, 1088.0]",figure_caption,0.92,"[""figure_title label: Fig. 21 Deep brain stimulation (DBS). (a) Mechanisms of DBS.""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 45,11,text,internal segment of the globus pallidus (GPi) are primarily targeted by DBS to mitigate symptoms of Parkinson's disease. $ ^{547} $ Both targets have been associated with similar improvements in motor,"[78.0, 1125.0, 589.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -45,12,text,,"[601.0, 1125.0, 1109.0, 1171.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +45,12,text,"noticeable when a generalized seizure is purposefully induced +during treatment.558","[601.0, 1125.0, 1109.0, 1171.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 45,13,text,"In epilepsy models, ES of specific brain regions like the mammillothalamic tract (MMT) or the anterior nucleus of the thalamus (ANT) showed anti-epileptic effects, highlighting the role of DBS in modu","[600.0, 1174.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 45,14,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 45,15,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1106.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -642,7 +750,9 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 46,4,text,"Moreover, DBS has been adopted to regulate mood-related behaviors by targeting specific brain regions that control emotions. Stimulating specific brain regions like the nucleus accumbens and lateral h","[77.0, 169.0, 589.0, 503.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 46,5,text,Different mechanisms of DBS exhibit varying time frames in terms of symptom improvement across different neurological conditions (Fig. 21c). $ ^{[521]} $ Tremor and rigidity respond almost immediately,"[78.0, 504.0, 588.0, 909.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_side_zone,body_like,none,True,True 46,6,text,"The left image in Fig. 21d shows a brain tissue cross-section with an electrode implant, underscoring the targeted region of this intervention for Parkinson's disease. $ ^{2} $ DBS relies on the preci","[78.0, 911.0, 589.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -46,7,text,,"[600.0, 98.0, 1110.0, 167.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +46,7,text,"over the spread of the electric current is essential, along with the +ability to adjust the DBS lead’s placement as necessary, without +resorting to physical relocation.569","[600.0, 98.0, 1110.0, 167.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 46,8,text,"The long-term efficacy of neural probes is often hindered by mechanical mismatches and immune responses, which can lead to complications such as movement at the probe-tissue interface, glial scarring,","[600.0, 169.0, 1111.0, 767.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 46,9,text,"Combining deep brain stimulation with imaging methods, such as functional magnetic resonance imaging (fMRI), can be challenging due to conventional metallic electrodes causing magnetic interference an","[600.0, 767.0, 1111.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 46,10,text,"Although DBS is widely used in clinical treatments, it is often invasive, and the detailed mechanisms are not fully understood, making it almost inevitably risky and potentially accompanied by complic","[600.0, 1245.0, 1111.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -654,20 +764,23 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 47,3,text,"leading to unintended consequences. Reported side effects in movement disorder treatments, such as Parkinson's disease targeting the STN, include hypomania, $ ^{580} $ depression (sometimes with psych","[77.0, 97.0, 589.0, 384.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 47,4,text,"Despite the high occurrence of side effects in DBS, it has been found that these incidents are related to stimulation directions and tend to occur when DBS exceeds certain thresholds, particularly in ","[78.0, 384.0, 588.0, 813.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 47,5,text,"6.2.2. Other electrical brain stimulation techniques. Deep brain techniques often use penetrating electrodes for brain stimulation, which can inflict brain damage. Transcranial ES (TES) applies electr","[79.0, 814.0, 589.0, 863.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True -47,6,text,,"[600.0, 97.0, 1112.0, 622.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +47,6,text,"stimulation, which can inflict brain damage. Transcranial ES +(TES) applies electrical pulses to the scalp to tune neural activity +in the brain.593 The configuration of TES generally involves +positioni","[600.0, 97.0, 1112.0, 622.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 47,7,text,"tDCS entails applying a steady, low-intensity electrical current to the scalp. This technique effectively modulates neuronal excitability by polarizing the underlying brain tissue. This method is favo","[599.0, 623.0, 1112.0, 865.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -47,8,figure_title,a,"[172.0, 911.0, 191.0, 932.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -47,9,image,,"[172.0, 910.0, 459.0, 1091.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -47,10,figure_title,b,"[460.0, 907.0, 480.0, 931.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -47,11,chart,,"[463.0, 908.0, 776.0, 1094.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,8,figure_title,a,"[172.0, 911.0, 191.0, 932.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,9,image,,"[172.0, 910.0, 459.0, 1091.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,10,figure_title,b,"[460.0, 907.0, 480.0, 931.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,11,chart,,"[463.0, 908.0, 776.0, 1094.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 47,12,figure_title,C,"[775.0, 911.0, 794.0, 932.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True -47,13,chart,,"[786.0, 918.0, 1019.0, 1089.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -47,14,figure_title,d,"[172.0, 1106.0, 193.0, 1132.0]",figure_caption_candidate,0.85,"[""figure_title label: d""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -47,15,chart,,"[209.0, 1111.0, 461.0, 1327.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -47,16,figure_title,e,"[494.0, 1109.0, 513.0, 1131.0]",figure_caption_candidate,0.85,"[""figure_title label: e""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False -47,17,image,,"[513.0, 1113.0, 769.0, 1316.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -47,18,chart,,"[772.0, 1115.0, 1018.0, 1324.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -47,19,figure_title,"Fig. 22 Transcranial ES. (a) Diagram depicting the three configuration for transcutaneous (scalp), subcutaneous (skull) and epidural (dura) stimulation.⁵¹⁹ (b) Neuronal compartment orientation influen","[80.0, 1334.0, 1111.0, 1436.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 22 Transcranial ES. (a) Diagram depicting the three con""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +47,13,chart,,"[786.0, 918.0, 1019.0, 1089.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,14,figure_title,d,"[172.0, 1106.0, 193.0, 1132.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,15,chart,,"[209.0, 1111.0, 461.0, 1327.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,16,figure_title,e,"[494.0, 1109.0, 513.0, 1131.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,17,image,,"[513.0, 1113.0, 769.0, 1316.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,18,chart,,"[772.0, 1115.0, 1018.0, 1324.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,19,figure_title,"Fig. 22 Transcranial ES. (a) Diagram depicting the three configuration for transcutaneous (scalp), subcutaneous (skull) and epidural (dura) stimulation.⁵¹⁹ (b) Neuronal compartment orientation influen","[80.0, 1334.0, 1111.0, 1436.0]",figure_caption,0.92,"[""figure_title label: Fig. 22 Transcranial ES. (a) Diagram depicting the three con""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 47,20,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 47,21,footer,Chem. Soc. Rev.,"[986.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 48,0,header,Review Article,"[81.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -677,7 +790,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 48,4,text,"On the other hand, tACS applies alternating current at specific frequencies to entrain brain oscillations and modulate neural activity, aiming to synchronize with existing brain rhythms to enhance cog","[78.0, 242.0, 589.0, 695.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 48,5,text,"The key difference between tDCS and tACS lies in their mechanisms of action: tDCS modulates neuronal excitability through polarization, while tACS entrains endogenous brain oscillations through freque","[78.0, 695.0, 589.0, 958.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 48,6,text,"One critical consideration in TES is the shunting effect. The shunting effect during TES refers to the tendency of the current to divert away from the brain, following the path of least resistance, ra","[78.0, 959.0, 589.0, 1440.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -48,7,text,,"[599.0, 98.0, 1112.0, 598.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +48,7,text,"To tackle this issue, M. Vo¨ro¨slakos and colleagues developed +an intersectional short pulse (ISP) technique that enables the +direct administration of increased current intensities into the +brain, whi","[599.0, 98.0, 1112.0, 598.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 48,8,text,"Compared with TES, cortical ES (CES) inserts electrodes directly on/into the cortical tissue. CES requires surgical exposure of the brain and is often used during neurosurgical procedures for brain ma","[600.0, 600.0, 1112.0, 1101.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 48,9,text,"Brain ES can induce sensory experiences, which are linked to the specific brain regions stimulated and the configuration of the ES. $ ^{604} $ Cortical stimulation within the somatosensory cortex has ","[598.0, 1102.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 48,10,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -685,55 +801,63 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 49,0,header,Chem Soc Rev,"[82.0, 50.0, 218.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 49,1,header,View Article Online,"[991.0, 20.0, 1107.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 49,2,header,Review Article,"[973.0, 50.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -49,3,image,,"[177.0, 104.0, 563.0, 313.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -49,4,image,,"[575.0, 104.0, 1013.0, 314.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -49,5,image,,"[177.0, 324.0, 535.0, 523.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -49,6,image,,"[548.0, 325.0, 1017.0, 520.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -49,7,image,,"[177.0, 541.0, 438.0, 737.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -49,8,image,,"[447.0, 538.0, 700.0, 737.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -49,9,image,,"[717.0, 536.0, 1016.0, 739.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -49,10,figure_title,Fig. 23 Electronics for cortical ES. (a) Schematic depiction of a graphene-based seizure sensor and epilepsy treatment stimulation sensors. $ ^{599} $ Reproduced from ref. 599 with permission from Joh,"[78.0, 751.0, 1112.0, 933.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 23 Electronics for cortical ES. (a) Schematic depiction""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +49,3,image,,"[177.0, 104.0, 563.0, 313.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +49,4,image,,"[575.0, 104.0, 1013.0, 314.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +49,5,image,,"[177.0, 324.0, 535.0, 523.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,6,image,,"[548.0, 325.0, 1017.0, 520.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,7,image,,"[177.0, 541.0, 438.0, 737.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,8,image,,"[447.0, 538.0, 700.0, 737.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,9,image,,"[717.0, 536.0, 1016.0, 739.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +49,10,figure_title,Fig. 23 Electronics for cortical ES. (a) Schematic depiction of a graphene-based seizure sensor and epilepsy treatment stimulation sensors. $ ^{599} $ Reproduced from ref. 599 with permission from Joh,"[78.0, 751.0, 1112.0, 933.0]",figure_caption,0.92,"[""figure_title label: Fig. 23 Electronics for cortical ES. (a) Schematic depiction""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 49,11,text,"visual cortex designed to return sight to those with complete blindness. $ ^{608} $ Each array features 43 active electrodes, alongside an electronic mechanism that is wirelessly powered to decode inc","[78.0, 983.0, 589.0, 1293.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 49,12,text,Traditional invasive electrode arrays for brain stimulation involve risky and invasive surgeries that may cause complications like inflammation and device failure. These methods offer high-resolution ,"[79.0, 1294.0, 589.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -49,13,text,,"[600.0, 982.0, 1111.0, 1439.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +49,13,text,"invasive procedures.610,611 A stent-mounted electrode array has been +shown to safely provide high-quality neural signals over extended +periods in animal models.612 Opie et al. developed a stent electr","[600.0, 982.0, 1111.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 49,14,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 49,15,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 50,0,header,Review Article,"[81.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 50,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 50,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 50,3,text,"Beyond the electrodes themselves, the system for signal collection in intracortical stimulation is also crucial for ES. $ ^{535,614} $ Lee et al. unveiled a cutting-edge approach for nerve recording a","[79.0, 98.0, 589.0, 193.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -50,4,text,,"[600.0, 97.0, 1111.0, 193.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True -50,5,figure_title,a,"[181.0, 242.0, 200.0, 261.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +50,4,text,"wirelessly networked and powered microscale implants +(Fig. 23e).603 These small-scale implants are engineered to +perform neural monitoring and provide targeted ES autono- +mously. They communicate bidi","[600.0, 97.0, 1111.0, 193.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +50,5,figure_title,a,"[181.0, 242.0, 200.0, 261.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True 50,6,image,,"[176.0, 237.0, 454.0, 361.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,7,image,,"[178.0, 364.0, 453.0, 485.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -50,8,figure_title,b,"[472.0, 241.0, 492.0, 263.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +50,8,figure_title,b,"[472.0, 241.0, 492.0, 263.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True 50,9,image,,"[465.0, 238.0, 814.0, 487.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,10,image,,"[827.0, 237.0, 1014.0, 387.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,11,image,,"[826.0, 392.0, 1011.0, 486.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -50,12,figure_title,d,"[183.0, 501.0, 202.0, 522.0]",figure_caption_candidate,0.85,"[""figure_title label: d""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +50,12,figure_title,d,"[183.0, 501.0, 202.0, 522.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True 50,13,image,,"[179.0, 496.0, 427.0, 690.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -50,14,figure_title,e,"[441.0, 499.0, 460.0, 517.0]",figure_caption_candidate,0.85,"[""figure_title label: e""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +50,14,figure_title,e,"[441.0, 499.0, 460.0, 517.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True 50,15,image,,"[440.0, 502.0, 643.0, 678.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,16,image,,"[646.0, 510.0, 825.0, 677.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,17,image,,"[835.0, 504.0, 1014.0, 683.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,18,image,,"[177.0, 699.0, 664.0, 1032.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True 50,19,image,,"[679.0, 697.0, 1015.0, 1033.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -50,20,figure_title,h,"[182.0, 1049.0, 200.0, 1071.0]",figure_caption_candidate,0.85,"[""figure_title label: h""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +50,20,figure_title,h,"[182.0, 1049.0, 200.0, 1071.0]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True 50,21,image,,"[178.0, 1052.0, 496.0, 1398.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,22,image,,"[503.0, 1063.0, 731.0, 1229.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,23,image,,"[751.0, 1055.0, 998.0, 1231.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,24,image,,"[502.0, 1233.0, 745.0, 1395.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -50,25,image,,"[751.0, 1236.0, 996.0, 1394.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,25,image,,"[751.0, 1236.0, 996.0, 1394.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 50,26,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 50,27,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 51,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 51,1,header,View Article Online,"[991.0, 20.0, 1107.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 51,2,header,Review Article,"[973.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -51,3,figure_title,Fig. 24 Spinal cord stimulation. (a) Photographs of a spinal implant and a 3D model obtained from high-resolution microcomputed tomography scans taken five weeks after the implant. (b) Reproduced from,"[81.0, 101.0, 1110.0, 401.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 24 Spinal cord stimulation. (a) Photographs of a spinal""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +51,3,figure_title,Fig. 24 Spinal cord stimulation. (a) Photographs of a spinal implant and a 3D model obtained from high-resolution microcomputed tomography scans taken five weeks after the implant. (b) Reproduced from,"[81.0, 101.0, 1110.0, 401.0]",figure_caption,0.92,"[""figure_title label: Fig. 24 Spinal cord stimulation. (a) Photographs of a spinal""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 51,4,text,"hub via a 1 GHz electromagnetic link that works through the skin, enabling personalized control over each device. Research involving 48 neurograins placed on a rat's brain demonstrates this system's a","[78.0, 453.0, 588.0, 862.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 51,5,paragraph_title,6.3. Spinal cord stimulation,"[80.0, 879.0, 324.0, 901.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.3. Spinal cord stimulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True 51,6,text,"ES of neural pathways in the spinal cord is facilitated by specialized electrodes designed to deliver precise electrical currents to targeted regions, thereby releasing pain, modulating neurological a","[78.0, 910.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -51,7,text,,"[600.0, 453.0, 1112.0, 1146.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +51,7,text,"Percutaneous linear-type electrodes are thin, flexible leads +that are inserted transdermally into the epidural space that +encases the spinal cord.624,628 These electrodes have multiple +contact points ","[600.0, 453.0, 1112.0, 1146.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 51,8,text,"The linear type is simpler to implant but tends to be less effective and more susceptible to shifting within the body. In contrast, the paddle-type provides more precise targeting and greater stabilit","[600.0, 1148.0, 1112.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 51,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 51,10,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -744,7 +868,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 52,4,text,"Developed from the gate control theory introduced by Wall and Melzack in 1965, SCS has advanced as a therapeutic approach for chronic pain conditions, notably failed back surgery syndrome and various ","[78.0, 218.0, 588.0, 791.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 52,5,text,"Besides pain relieving, SCS is also used for achieving functional movements in patients with severe spinal cord injuries. $ ^{525,527,630} $ As epidural SCS can have an impact on the neural circuitry ","[78.0, 790.0, 589.0, 1172.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 52,6,text,"By stimulating the spinal cord below the level of injury, SCS aims to enhance sensory input, promote motor function, and potentially improve bladder and bowel control. $ ^{621} $ After a severe spinal","[78.0, 1174.0, 588.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -52,7,text,,"[601.0, 97.0, 1110.0, 191.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +52,7,text,"implanted neurostimulator, a multi-electrode paddle lead, +and a robotic support system to enable a group of individuals +with chronic spinal cord injuries to regain functional abilities +as shown in Fig","[601.0, 97.0, 1110.0, 191.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 52,8,text,"Lateral lumbosacral SCS enables individuals with lower-limb amputations to perceive sensations as if they are coming from their missing foot, which helps restore somatosensory feedback, enhances balan","[600.0, 193.0, 1111.0, 480.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 52,9,text,"A major issue following SCI is the loss of voluntary bladder control, $ ^{639} $ leading to involuntary voiding and coordination problems between bladder contraction and sphincter relaxation. $ ^{640,","[600.0, 480.0, 1111.0, 886.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 52,10,text,It's important to note that spinal neural stimulation is typically considered after other conservative treatment options have been exhausted. The specific application and suitability of SCS depend on ,"[600.0, 887.0, 1111.0, 1103.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -755,11 +882,14 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 53,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 53,1,header,View Article Online,"[991.0, 20.0, 1107.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 53,2,header,Review Article,"[973.0, 49.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -53,3,image,,"[139.0, 100.0, 1052.0, 794.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -53,4,figure_title,"Fig. 25 Vagus nerve stimulation. (a) Demonstration of the vagal circuitry that connects the central and peripheral nervous systems. $ ^{649} $ Reproduced from ref. 649, originally published by and use","[78.0, 803.0, 1112.0, 945.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 25 Vagus nerve stimulation. (a) Demonstration of the va""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +53,3,image,,"[139.0, 100.0, 1052.0, 794.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +53,4,figure_title,"Fig. 25 Vagus nerve stimulation. (a) Demonstration of the vagal circuitry that connects the central and peripheral nervous systems. $ ^{649} $ Reproduced from ref. 649, originally published by and use","[78.0, 803.0, 1112.0, 945.0]",figure_caption,0.92,"[""figure_title label: Fig. 25 Vagus nerve stimulation. (a) Demonstration of the va""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 53,5,text,"for drug-resistant epilepsy and depression in patients. $ ^{643} $ VNS plays a crucial role in autonomic regulation, making it a valuable therapeutic option for a variety of conditions, including epil","[78.0, 981.0, 588.0, 1148.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 53,6,text,"Vagal circuitry serves as a bidirectional communication pathway between the central and peripheral nervous systems, playing a vital role in regulating inflammation and maintaining homeostasis (Fig. 25","[78.0, 1150.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -53,7,text,,"[601.0, 983.0, 1110.0, 1077.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +53,7,text,"effects and potentially restoring autonomic balance by reducing +pro-inflammatory cytokines such as IL-6, TNFa, and IL-1b, offer- +ing potential therapeutic benefits for conditions like cardiovas- +cular d","[601.0, 983.0, 1110.0, 1077.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 53,8,text,"Studies have shown that VNS aids in rebalancing parasympathetic and sympathetic nervous system activities, effectively diminishing inflammation and helping to halt the progression of conditions like s","[600.0, 1079.0, 1111.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 53,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 53,10,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -770,7 +900,9 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 54,4,text,"Transcutaneous VNS (tVNS) offers a promising non-invasive alternative to invasive VNS for various medical conditions. $ ^{642} $ tVNS is an affordable and straightforward technique, ideally administer","[78.0, 671.0, 588.0, 1173.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 54,5,text,There are some types of electrodes commonly used for vagus and peripheral nerve stimulation. $ ^{531} $ Surface electrodes are non-invasive electrodes placed on the skin surface over the targeted peri,"[78.0, 1173.0, 588.0, 1365.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 54,6,text,"Both the vagus nerves and peripheral nerves have a similar narrow and elongated anatomy, making them accessible for such interventions. $ ^{10} $ The contemporary implantable VNS device, like the Liva","[78.0, 1367.0, 589.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -54,7,text,,"[601.0, 97.0, 1111.0, 694.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +54,7,text,"like the Livanovar stimulator, features a compact, battery-operated +stimulator, which is surgically implanted and configured to deliver +ES to the vagus nerve, typically encircling the left cervical va","[601.0, 97.0, 1111.0, 694.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 54,8,text,Fig. 26c addresses the challenge of designing self-rolled neural interfaces that can effectively match the complex shapes and movements of nerves. $ ^{30} $ This study presents a novel approach utiliz,"[600.0, 695.0, 1111.0, 958.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Fig. 26c addresses the challenge of designing self-rolled ne""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True 54,9,text,"To address the issues faced by traditional bioelectronic devices, which are unsuitable for young patients with rapidly growing tissues, morphing electronics have been introduced. Liu et al. synthesize","[600.0, 958.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 54,10,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -778,10 +910,13 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 55,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 55,1,header,View Article Online,"[991.0, 20.0, 1107.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 55,2,header,Review Article,"[973.0, 49.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -55,3,image,,"[135.0, 95.0, 1053.0, 903.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -55,4,figure_title,Fig. 26 Bioelectronics for vagus nerve and peripheral nerve stimulation. (a) Photomicrographs show small vagus and peripheral nerves in rats alongside a schematic detailing how the flexible neural cli,"[78.0, 912.0, 1113.0, 1114.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 26 Bioelectronics for vagus nerve and peripheral nerve ""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +55,3,image,,"[135.0, 95.0, 1053.0, 903.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +55,4,figure_title,Fig. 26 Bioelectronics for vagus nerve and peripheral nerve stimulation. (a) Photomicrographs show small vagus and peripheral nerves in rats alongside a schematic detailing how the flexible neural cli,"[78.0, 912.0, 1113.0, 1114.0]",figure_caption,0.92,"[""figure_title label: Fig. 26 Bioelectronics for vagus nerve and peripheral nerve ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 55,5,text,PNS and VNS have emerged as revolutionary approaches in the treatment of various diseases and the elicitation of sensations. By delivering targeted electrical impulses to peripheral nerves or the vagu,"[78.0, 1147.0, 589.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -55,6,text,,"[601.0, 1147.0, 1110.0, 1244.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +55,6,text,"patients with sensory deficits. Through precise intervention, +PNS and VNS stand at the forefront of a new era in personalized +medicine, where the modulation of electrical signals in the +body can lead ","[601.0, 1147.0, 1110.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 55,7,paragraph_title,7. ES based bioelectronics for other applications,"[601.0, 1285.0, 1076.0, 1350.0]",section_heading,0.85,"[""paragraph_title label with numbering: 7. ES based bioelectronics for other applications""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True 55,8,text,"ES has become a versatile tool in biofunctional applications, offering a bridge between electronic systems and biological functions. By delivering targeted electrical impulses, this","[600.0, 1365.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 55,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -790,20 +925,23 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 56,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 56,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 56,3,text,"technology can be employed to regulate heart rhythms in pacemakers, facilitate muscle rehabilitation, control acute pain, diminish tremors associated with neurological disorders, and modulate sensory ","[79.0, 97.0, 589.0, 217.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -56,4,text,,"[600.0, 96.0, 1112.0, 216.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True -56,5,figure_title,a,"[179.0, 286.0, 197.0, 305.0]",figure_caption_candidate,0.85,"[""figure_title label: a""]",figure_caption,0.85,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -56,6,image,,"[175.0, 282.0, 788.0, 577.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -56,7,image,,"[802.0, 280.0, 1010.0, 434.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -56,8,image,,"[800.0, 443.0, 1005.0, 563.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -56,9,figure_title,b,"[177.0, 592.0, 194.0, 615.0]",figure_caption_candidate,0.85,"[""figure_title label: b""]",figure_caption,0.85,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -56,10,chart,,"[177.0, 597.0, 569.0, 777.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,4,text,"biological processes, thus holding the promise of +improved quality of life for individuals with various medical +conditions. This adaptability underscores the potential of ES +to revolutionize treatment","[600.0, 96.0, 1112.0, 216.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +56,5,figure_title,a,"[179.0, 286.0, 197.0, 305.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +56,6,image,,"[175.0, 282.0, 788.0, 577.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,7,image,,"[802.0, 280.0, 1010.0, 434.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,8,image,,"[800.0, 443.0, 1005.0, 563.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,9,figure_title,b,"[177.0, 592.0, 194.0, 615.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +56,10,chart,,"[177.0, 597.0, 569.0, 777.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True 56,11,figure_title,C,"[584.0, 594.0, 603.0, 614.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True -56,12,image,,"[583.0, 588.0, 1016.0, 766.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -56,13,image,,"[185.0, 787.0, 559.0, 971.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -56,14,figure_title,d,"[585.0, 780.0, 603.0, 804.0]",figure_caption_candidate,0.85,"[""figure_title label: d""]",figure_caption,0.85,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -56,15,image,,"[583.0, 778.0, 1017.0, 974.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -56,16,image,,"[177.0, 996.0, 1015.0, 1221.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -56,17,figure_title,"Fig. 27 Pacemaker. (a) This bioelectronic device is affixed to the epicardium using an adhesive hydrogel patch that enables recording of cardiac pressure and provides electrical therapy (left), which ","[79.0, 1236.0, 1112.0, 1435.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 27 Pacemaker. (a) This bioelectronic device is affixed ""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +56,12,image,,"[583.0, 588.0, 1016.0, 766.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,13,image,,"[185.0, 787.0, 559.0, 971.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,14,figure_title,d,"[585.0, 780.0, 603.0, 804.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +56,15,image,,"[583.0, 778.0, 1017.0, 974.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,16,image,,"[177.0, 996.0, 1015.0, 1221.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,17,figure_title,"Fig. 27 Pacemaker. (a) This bioelectronic device is affixed to the epicardium using an adhesive hydrogel patch that enables recording of cardiac pressure and provides electrical therapy (left), which ","[79.0, 1236.0, 1112.0, 1435.0]",figure_caption,0.92,"[""figure_title label: Fig. 27 Pacemaker. (a) This bioelectronic device is affixed ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 56,18,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 56,19,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 57,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False @@ -814,7 +952,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 57,5,text,"Cardiomyocytes naturally produce electrical impulses that initiate in the sinoatrial node and travel through the heart's conduction system, ultimately leading to coordinated muscle contractions that p","[78.0, 438.0, 588.0, 769.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 57,6,text,Implantable pacemakers require materials that ensure stability and biocompatibility for long-term patient care within the body's challenging biochemical environment. Hwang et al. introduced a novel si,"[78.0, 770.0, 588.0, 1292.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 57,7,text,"Biodegradable pacemakers are a groundbreaking advancement in temporary cardiac pacing, removing the necessity for surgical device removal and lowering the risk of associated infections. $ ^{669,670} $","[78.0, 1293.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -57,8,text,,"[599.0, 97.0, 1111.0, 311.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +57,8,text,"glycolic acids.671 Mg is also used, particularly for electrodes, +because of its biocompatibility and adjustable degradation rates, +ensuring that the device dissolves predictably after its therapeu- +ti","[599.0, 97.0, 1111.0, 311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 57,9,text,"The success of implantable pacemakers relies heavily on stable power sources, such as traditional internal batteries like lithium–iodine or lithium–silver vanadium oxide cells, which eventually requir","[599.0, 312.0, 1111.0, 1081.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 57,10,paragraph_title,7.2. Pain block,"[602.0, 1094.0, 743.0, 1117.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 7.2. Pain block""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True 57,11,text,"Pain is a complex bodily response with both sensory and emotional components, triggered by harmful stimuli. It can manifest as acute pain, which is a direct response to injury, or chronic pain, which ","[599.0, 1126.0, 1112.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True @@ -824,9 +965,12 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 58,1,header,View Article Online,"[991.0, 19.0, 1108.0, 37.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 58,2,header,Chem Soc Rev,"[972.0, 49.0, 1109.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 58,3,text,"by Melzack and Wall, who offered a physiological explanation for its effectiveness. $ ^{638} $ This method is widely utilized to relieve pain in various medical conditions, including labor, dysmenorrh","[78.0, 97.0, 588.0, 289.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -58,4,text,,"[600.0, 97.0, 1111.0, 290.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True -58,5,image,,"[175.0, 362.0, 1015.0, 1242.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -58,6,figure_title,Fig. 28 Pain block. (a) Commonly targeted locations for ES used in blocking pain. $ ^{680} $ (b) Hypothesized modes of action for analgesia induced by TENS. $ ^{680} $ Adapted from ref. 680 with permi,"[78.0, 1252.0, 1111.0, 1435.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 28 Pain block. (a) Commonly targeted locations for ES u""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +58,4,text,"TENS is a non-invasive technique that uses a portable pulse +generator and adhesive pads affixed to the skin to manage +various types of pain, with its effectiveness influenced by the +proximity of the elec","[600.0, 97.0, 1111.0, 290.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +58,5,image,,"[175.0, 362.0, 1015.0, 1242.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +58,6,figure_title,Fig. 28 Pain block. (a) Commonly targeted locations for ES used in blocking pain. $ ^{680} $ (b) Hypothesized modes of action for analgesia induced by TENS. $ ^{680} $ Adapted from ref. 680 with permi,"[78.0, 1252.0, 1111.0, 1435.0]",figure_caption,0.92,"[""figure_title label: Fig. 28 Pain block. (a) Commonly targeted locations for ES u""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 58,7,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 58,8,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 59,0,header,Chem Soc Rev,"[81.0, 49.0, 219.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False @@ -834,7 +978,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 59,2,header,Review Article,"[972.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 59,3,text,"impulses. (Fig. 28b) $ ^{680} $ In the segmental pain-block mechanism, TENS reduces ongoing nociceptor activity and CNS sensitization when applied to somatic receptive fields, even after spinal cord t","[77.0, 96.0, 590.0, 1318.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 59,4,text,"When placing TENS electrodes, ensure that they are applied to healthy, sensate skin. Position the electrodes on relevant dermatomes to direct paraesthesia into the painful area, except in cases of hyp","[78.0, 1317.0, 589.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -59,5,text,,"[600.0, 98.0, 1111.0, 263.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +59,5,text,"the electrodes along the main nerves proximal to the pain, +paravertebrally at spinal segments, or at contralateral mirror +sites. For large or multiple pain areas, use dual-channel TENS +devices with fo","[600.0, 98.0, 1111.0, 263.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 59,6,text,Percutaneous electrical nerve stimulation (PENS) is an invasive form of pain management therapy that entails the insertion of fine needles through the skin to target specific nerve pathways directly (,"[599.0, 264.0, 1111.0, 1079.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 59,7,text,"Compared with PENS, invasive cuff-shaped nerve electrodes attach directly to peripheral nerves and deliver stimulation that blocks nerve conduction effectively and rapidly, usually in less than 10 ms,","[599.0, 1078.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 59,8,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1493.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False @@ -847,43 +994,49 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 60,5,paragraph_title,7.3. Tremor reduction,"[81.0, 664.0, 277.0, 686.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 7.3. Tremor reduction""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True 60,6,text,"Tremor is an involuntary, rhythmic oscillation of muscle, resulting in tremulous movement. This phenomenon is most frequently observed in the hands, although it may manifest in other parts of the body","[78.0, 695.0, 588.0, 1294.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 60,7,text,"Tremor reduction through peripheral ES employs two main strategies: functional ES (FES), which creates forces in tremor-producing muscles to mechanically reduce tremors, and afferent pathway stimulati","[78.0, 1294.0, 589.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -60,8,text,,"[601.0, 97.0, 1111.0, 216.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +60,8,text,"management include employing FES to activate antagonistic +muscle forces, stimulating afferent fibers to decrease motor +neuron excitability, and activating cutaneous afferent fibers to +suppress interneur","[601.0, 97.0, 1111.0, 216.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 60,9,text,FES represents a therapeutic modality of neuromuscular ES designed to facilitate or rehabilitate functional muscle activity. This is achieved through the administration of electrical pulses at an inte,"[600.0, 217.0, 1111.0, 671.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 60,10,text,Afferent pathway ES offers a therapeutic strategy distinct from traditional FES by targeting sensory rather than motor pathways to alleviate tremor. This novel approach applied sub-motor-threshold ele,"[599.0, 672.0, 1112.0, 1078.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 60,11,text,"In addition to stimulating peripheral nerves, DBS targeting the STN is a recognized and effective treatment for managing tremors. However, its effects on complex everyday movements are not as well und","[599.0, 1079.0, 1112.0, 1342.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 60,12,paragraph_title,7.4. Sensory modulation,"[601.0, 1358.0, 818.0, 1380.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 7.4. Sensory modulation""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True -60,13,text,"ES, as both a therapeutic modality and an enhancement technology, introduces novel avenues for broadening the","[600.0, 1389.0, 1110.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +60,13,text,"ES, as both a therapeutic modality and an enhancement technology, introduces novel avenues for broadening the","[600.0, 1389.0, 1110.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 60,14,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 60,15,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 61,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 61,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 61,2,header,Review Article,"[973.0, 49.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -61,3,image,,"[178.0, 104.0, 1017.0, 505.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -61,4,image,,"[175.0, 511.0, 535.0, 761.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -61,5,image,,"[541.0, 515.0, 813.0, 756.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -61,6,image,,"[814.0, 516.0, 1016.0, 756.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -61,7,image,,"[175.0, 767.0, 531.0, 998.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -61,8,image,,"[543.0, 770.0, 1015.0, 1001.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -61,9,figure_title,Fig. 29 Tremor reduction. (a) The underlying mechanism by which ES can mitigate tremors involves the disruption of tremorgenic signals. (i) The signals originate from a central brain oscillator and re,"[78.0, 1013.0, 1113.0, 1256.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 29 Tremor reduction. (a) The underlying mechanism by wh""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +61,3,image,,"[178.0, 104.0, 1017.0, 505.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,4,image,,"[175.0, 511.0, 535.0, 761.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,5,image,,"[541.0, 515.0, 813.0, 756.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,6,image,,"[814.0, 516.0, 1016.0, 756.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,7,image,,"[175.0, 767.0, 531.0, 998.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,8,image,,"[543.0, 770.0, 1015.0, 1001.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,9,figure_title,Fig. 29 Tremor reduction. (a) The underlying mechanism by which ES can mitigate tremors involves the disruption of tremorgenic signals. (i) The signals originate from a central brain oscillator and re,"[78.0, 1013.0, 1113.0, 1256.0]",figure_caption,0.92,"[""figure_title label: Fig. 29 Tremor reduction. (a) The underlying mechanism by wh""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 61,10,text,"spectrum of human sensory experiences. This technique leverages precise electrical signals to strategically activate or modulate designated pathways within the nervous system, thereby simulating the n","[79.0, 1293.0, 589.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -61,11,text,,"[600.0, 1293.0, 1109.0, 1339.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +61,11,text,"encompassing auditory, visual, olfactory, taste, and tactile +modalities.715,716","[600.0, 1293.0, 1109.0, 1339.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 61,12,text,"7.4.1. Auditory. ES has significantly advanced the field of hearing, particularly with cochlear implants, which are a groundbreaking solution for individuals with severe to profound sensorineural hear","[601.0, 1342.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True 61,13,footer,This journal is © The Royal Society of Chemistry 2024,"[83.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 61,14,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 62,0,header,Review Article,"[82.0, 49.0, 217.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 62,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 62,2,header,Chem Soc Rev,"[973.0, 50.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -62,3,image,,"[138.0, 109.0, 407.0, 344.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,4,image,,"[416.0, 115.0, 717.0, 337.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,5,image,,"[736.0, 118.0, 1046.0, 333.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,6,image,,"[143.0, 363.0, 680.0, 582.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,7,image,,"[692.0, 359.0, 1048.0, 572.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,8,image,,"[151.0, 595.0, 398.0, 793.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,9,image,,"[418.0, 595.0, 657.0, 792.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,10,image,,"[688.0, 584.0, 1044.0, 797.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -62,11,figure_title,"Fig. 30 Auditory, visual, smell and taste modulation by ES. (a) Auditory modulation. (i) A standard contemporary cochlear implant system transforms sound into electrical impulses, which are subsequent","[77.0, 812.0, 1113.0, 1195.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 30 Auditory, visual, smell and taste modulation by ES. ""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +62,3,image,,"[138.0, 109.0, 407.0, 344.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,4,image,,"[416.0, 115.0, 717.0, 337.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,5,image,,"[736.0, 118.0, 1046.0, 333.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,6,image,,"[143.0, 363.0, 680.0, 582.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,7,image,,"[692.0, 359.0, 1048.0, 572.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,8,image,,"[151.0, 595.0, 398.0, 793.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,9,image,,"[418.0, 595.0, 657.0, 792.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,10,image,,"[688.0, 584.0, 1044.0, 797.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,11,figure_title,"Fig. 30 Auditory, visual, smell and taste modulation by ES. (a) Auditory modulation. (i) A standard contemporary cochlear implant system transforms sound into electrical impulses, which are subsequent","[77.0, 812.0, 1113.0, 1195.0]",figure_caption,0.92,"[""figure_title label: Fig. 30 Auditory, visual, smell and taste modulation by ES. ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 62,12,text,"nonfunctional hair cells by transforming sound signals into electrical impulses that stimulate the cochlea's neural elements. This process enables sound perception in the brain, effectively restoring ","[78.0, 1245.0, 588.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -62,13,text,,"[600.0, 1245.0, 1111.0, 1438.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +62,13,text,"and minimal interference with the surrounding tissues. Electrode +arrays are usually made of durable alloys like TiN, Ti–Ir, titanium– +tantalum, IrOx, and Pt–Ir (Fig. 30a(ii)).20,722,723 Dalrymple et a","[600.0, 1245.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 62,14,footer,Chem. Soc. Rev.,"[83.0, 1494.0, 204.0, 1513.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 62,15,footer,This journal is © The Royal Society of Chemistry 2024,"[710.0, 1494.0, 1108.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 63,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False @@ -893,7 +1046,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 63,4,text,"Advancements in cochlear implant technology have included improved insertion techniques for gentler surgery, increased electrode numbers, and refined stimulation protocols. $ ^{720,741} $ However, the","[78.0, 719.0, 588.0, 958.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 63,5,text,"7.4.2. Vision. In visual rehabilitation, ES is a key technique in activating retinal implants that provide signals to neurons under a damaged retina, enabling basic light and shape perception for some","[78.0, 959.0, 588.0, 1341.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True 63,6,text,Retinal implants using ES are gaining favor in clinical trials due to their ability to tap into the visual pathway's natural processing and their proven effectiveness in restoring functional vision. $,"[78.0, 1342.0, 589.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -63,7,text,,"[600.0, 97.0, 1112.0, 312.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +63,7,text,"significant improvements in the daily activities and mobility of +72% of trial participants over 12 months, with 45% reporting +restored visual functions for everyday use.747 This implant +featured a mic","[600.0, 97.0, 1112.0, 312.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 63,8,text,Stimulating the optic nerve is an effective approach that bypasses the complex retinal structure directly targeting nerve fibers. This technique preserves the advanced information processing of later ,"[600.0, 312.0, 1111.0, 909.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 63,9,text,"ES has witnessed considerable advancements in the realm of vision restoration and the treatment of blindness, with mounting evidence indicating its burgeoning potential in ameliorating a spectrum of v","[600.0, 911.0, 1111.0, 1221.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 63,10,text,"7.4.3. Olfaction and taste. Olfaction and taste are critical chemical senses that discern chemical stimuli, aiding in survival by attracting us to nutritious foods and repelling us from dangers like t","[600.0, 1222.0, 1111.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True @@ -906,7 +1062,10 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 64,4,text,"ES is a burgeoning area of research for mimicking or restoring the sense of taste. $ ^{755,763} $ Ranasinghe et al. were at the forefront with their “Digital Lollipop,” an innovative device that simul","[78.0, 623.0, 589.0, 958.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 64,5,text,"7.4.4. Haptics. Tactile afferents in the hand transmit details regarding the physical properties of objects and the nature of contact during manipulation, which is critical for everyday activities. $ ","[78.0, 959.0, 589.0, 1340.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True 64,6,text,"Skin electronics and TENS are fascinating aspects of human-machine interface technology that have the capability to induce tactile sensations, effectively tricking the sense of touch. These electrodes","[78.0, 1341.0, 589.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -64,7,text,,"[599.0, 97.0, 1112.0, 647.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +64,7,text,"work by delivering safe, low-level electrical currents that stimu- +late the cutaneous nerves (Fig. 31a).776 The stimulation can +mimic diverse tactile sensations, like pressure, vibration, or +even text","[599.0, 97.0, 1112.0, 647.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 64,8,text,"Implanted peripheral nerve interfaces could enable individuals with limb amputations to experience consistent, natural touch sensations in their phantom hands. Tan et al. designed a kind of cuff elect","[600.0, 648.0, 1112.0, 1102.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 64,9,text,"The development of implantable devices has long faced the issue of establishing a reliable and long-lasting method for transcutaneous communication, particularly for prosthetic limbs that require intu","[598.0, 1101.0, 1112.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 64,10,footer,Chem. Soc. Rev.,"[82.0, 1494.0, 204.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False @@ -914,69 +1073,74 @@ View Journal","[900.0, 184.0, 1075.0, 230.0]",frontmatter_noise,0.9,"[""journal 65,0,header,Chem Soc Rev,"[82.0, 50.0, 218.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 65,1,header,View Article Online,"[991.0, 20.0, 1108.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 65,2,header,Review Article,"[973.0, 49.0, 1108.0, 70.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -65,3,image,,"[139.0, 95.0, 1052.0, 967.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -65,4,figure_title,Fig. 31 Haptic modulation and human machine interfaces. (a) A schematic graph showing the electrotactile process where an electrode is attached on the fingertip. $ ^{776} $ Reproduced from ref. 775 wi,"[78.0, 985.0, 1112.0, 1206.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 31 Haptic modulation and human machine interfaces. (a) ""]",figure_caption,0.92,display_zone,support_like,figure_number,False,False +65,3,image,,"[139.0, 95.0, 1052.0, 967.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +65,4,figure_title,Fig. 31 Haptic modulation and human machine interfaces. (a) A schematic graph showing the electrotactile process where an electrode is attached on the fingertip. $ ^{776} $ Reproduced from ref. 775 wi,"[78.0, 985.0, 1112.0, 1206.0]",figure_caption,0.92,"[""figure_title label: Fig. 31 Haptic modulation and human machine interfaces. (a) ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True 65,5,text,"provides sensory feedback via neurostimulation, improving the prosthetic limb's natural sensation. This technology marks substantial progress in mimicking natural limb functionality, offering stable a","[79.0, 1243.0, 588.0, 1362.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 65,6,text,"An ideal prosthetic replacement should provide the user with natural-like sensations when grasping or manipulating objects, which requires the simultaneous and real-time decoding of user intent and de","[79.0, 1364.0, 588.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -65,7,text,,"[600.0, 1243.0, 1111.0, 1435.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +65,7,text,"decoding of user intent and delivery of sensory +feedback.618,781 While peripheral nervous system neural inter- +faces have shown potential, there has been no conclusive +evidence of their effectiveness i","[600.0, 1243.0, 1111.0, 1435.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 65,8,footer,This journal is © The Royal Society of Chemistry 2024,"[82.0, 1494.0, 480.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 65,9,footer,Chem. Soc. Rev.,"[987.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 66,0,header,Review Article,"[82.0, 48.0, 217.0, 72.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 66,1,header,"View Article Online Chem Soc Rev","[973.0, 19.0, 1109.0, 72.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -66,2,figure_title,Table 2 ES based bioelectronics for different biomedical applications,"[91.0, 944.0, 113.0, 1433.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 2 ES based bioelectronics for different biomedical app""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +66,2,figure_title,Table 2 ES based bioelectronics for different biomedical applications,"[91.0, 944.0, 113.0, 1433.0]",table_caption,0.9,"[""table prefix matched: Table 2 ES based bioelectronics for different biomedical app""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True 66,3,table,
CElectrical modulationNeuroplasticityNeuronal reorganization
PDTremorRigidityAxial symptoms
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
typesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
typesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
Long-term natural touc,"[142.0, 91.0, 510.0, 1431.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True -70,5,text,"must be contracted and touch sensations felt simultaneously (Fig. 31e). $ ^{780,782} $ This sensory feedback allowed the test subject to modulate the prosthesis's grasping force accurately without rel","[602.0, 97.0, 1110.0, 239.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -70,6,text,"Advancements in ES technology are continually expanding the horizons of human sensory exploration, offering the promise of transforming our interaction with the world and enriching our quality of life","[602.0, 241.0, 1110.0, 409.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,3,figure_title,Table 2 (continued),"[90.0, 1281.0, 110.0, 1431.0]",table_caption,0.9,"[""table prefix matched: Table 2 (continued)""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +70,4,table,
TypesDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
Long-term natural touc,"[142.0, 91.0, 510.0, 1431.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +70,5,text,"must be contracted and touch sensations felt simultaneously (Fig. 31e). $ ^{780,782} $ This sensory feedback allowed the test subject to modulate the prosthesis's grasping force accurately without rel","[602.0, 97.0, 1110.0, 239.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,6,text,"Advancements in ES technology are continually expanding the horizons of human sensory exploration, offering the promise of transforming our interaction with the world and enriching our quality of life","[602.0, 241.0, 1110.0, 409.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 70,7,paragraph_title,8. Conclusion and outlook,"[603.0, 457.0, 958.0, 485.0]",section_heading,0.85,"[""paragraph_title label with numbering: 8. Conclusion and outlook""]",section_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True -70,8,text,"In this review, we have explored the intricate mechanisms and diverse applications of ES and its associated bioelectronics, highlighting its profound impact on cellular behavior and potential for ther","[600.0, 502.0, 1110.0, 1172.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -70,9,text,"The future of ES is set to expand with advancements in bioelectronics, materials science, and nanotechnology. Emerging technologies are expected to enhance the precision, efficiency, and adaptability ","[602.0, 1173.0, 1110.0, 1389.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -70,10,text,"Looking ahead, future advancements in bioelectronics for ES are expected to benefit greatly from breakthroughs in","[602.0, 1390.0, 1110.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,8,text,"In this review, we have explored the intricate mechanisms and diverse applications of ES and its associated bioelectronics, highlighting its profound impact on cellular behavior and potential for ther","[600.0, 502.0, 1110.0, 1172.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,9,text,"The future of ES is set to expand with advancements in bioelectronics, materials science, and nanotechnology. Emerging technologies are expected to enhance the precision, efficiency, and adaptability ","[602.0, 1173.0, 1110.0, 1389.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,10,text,"Looking ahead, future advancements in bioelectronics for ES are expected to benefit greatly from breakthroughs in","[602.0, 1390.0, 1110.0, 1438.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 70,11,footer,Chem. Soc. Rev.,"[84.0, 1493.0, 203.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False 70,12,footer,This journal is © The Royal Society of Chemistry 2024,"[711.0, 1494.0, 1107.0, 1514.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False 71,0,header,Chem Soc Rev,"[82.0, 49.0, 218.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 71,1,header,View Article Online,"[991.0, 19.0, 1107.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 71,2,header,Review Article,"[973.0, 49.0, 1108.0, 71.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -71,3,text,"materials science. The development of biocompatible, flexible, and highly conductive materials will enhance the integration of electronic devices with biological tissues, promising higher efficiency a","[78.0, 97.0, 588.0, 311.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -71,4,text,"As our understanding of the bioelectrical underpinnings of diseases advances, ES can be customized to individual physiological and pathological conditions, ushering in a new era of precision medicine.","[78.0, 313.0, 589.0, 551.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -71,5,text,The integration of ES devices with wireless technologies and the Internet of Medical Things could significantly enhance the monitoring and real-time adjustment of therapies. These systems could enable,"[78.0, 551.0, 588.0, 767.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +71,3,text,"materials science. The development of biocompatible, flexible, and highly conductive materials will enhance the integration of electronic devices with biological tissues, promising higher efficiency a","[78.0, 97.0, 588.0, 311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,4,text,"As our understanding of the bioelectrical underpinnings of diseases advances, ES can be customized to individual physiological and pathological conditions, ushering in a new era of precision medicine.","[78.0, 313.0, 589.0, 551.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,5,text,The integration of ES devices with wireless technologies and the Internet of Medical Things could significantly enhance the monitoring and real-time adjustment of therapies. These systems could enable,"[78.0, 551.0, 588.0, 767.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 71,6,text,"As ES technologies advance and become more popular in routine clinical practices, ethical and regulatory frameworks will need to evolve accordingly. The potential for these technologies to modify neur","[78.0, 768.0, 589.0, 1005.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True 71,7,text,"ES stands as a dynamic and versatile tool in bioelectronics, poised to make significant contributions to healthcare and medicine. By continuing to explore the complex interactions between electrical f","[78.0, 1007.0, 588.0, 1294.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -71,8,paragraph_title,Data availability,"[81.0, 1342.0, 289.0, 1372.0]",backmatter_heading,0.8,"[""backmatter heading on page 71: Data availability""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,heading_like,short_fragment,True,True -71,9,text,This review does not include any new research data generated by the authors. All figures presented in this review are used with proper authorization from the original sources. The original sources of ,"[78.0, 1388.0, 587.0, 1437.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -71,10,text,,"[601.0, 97.0, 1110.0, 169.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True -71,11,paragraph_title,Conflicts of interest,"[602.0, 201.0, 866.0, 231.0]",backmatter_heading,0.8,"[""backmatter heading on page 71: Conflicts of interest""]",backmatter_heading_candidate,0.8,body_zone,heading_like,none,True,True -71,12,text,There are no conflicts to declare.,"[601.0, 248.0, 873.0, 271.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -71,13,paragraph_title,Acknowledgements,"[602.0, 306.0, 864.0, 335.0]",backmatter_heading,0.8,"[""backmatter heading on page 71: Acknowledgements""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True -71,14,text,"This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region (Grant No. RFS2324-1S03, 11213721, 11215722, and 11211523), the Innovation and Technology Fund of ","[600.0, 352.0, 1111.0, 617.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,8,paragraph_title,Data availability,"[81.0, 1342.0, 289.0, 1372.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data availability""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +71,9,text,This review does not include any new research data generated by the authors. All figures presented in this review are used with proper authorization from the original sources. The original sources of ,"[78.0, 1388.0, 587.0, 1437.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +71,10,text,"with proper authorization from the original sources. The origi- +nal sources of all figures can be found in the corresponding +captions.","[601.0, 97.0, 1110.0, 169.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,11,paragraph_title,Conflicts of interest,"[602.0, 201.0, 866.0, 231.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflicts of interest""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +71,12,text,There are no conflicts to declare.,"[601.0, 248.0, 873.0, 271.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,13,paragraph_title,Acknowledgements,"[602.0, 306.0, 864.0, 335.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +71,14,text,"This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region (Grant No. RFS2324-1S03, 11213721, 11215722, and 11211523), the Innovation and Technology Fund of ","[600.0, 352.0, 1111.0, 617.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 71,15,paragraph_title,References,"[604.0, 648.0, 753.0, 678.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True 71,16,reference_content,"1 J. Liu, et al., Nat. Nanotechnol., 2015, 10, 629.","[621.0, 696.0, 1007.0, 718.0]",reference_item,0.85,"[""reference content label: 1 J. Liu, et al., Nat. Nanotechnol., 2015, 10, 629.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 71,17,reference_content,"2 M. L. Kringelbach, N. Jenkinson, S. L. F. Owen and T. Z. Aziz, Nat. Rev. Neurosci., 2007, 8, 623.","[620.0, 721.0, 1108.0, 765.0]",reference_item,0.85,"[""reference content label: 2 M. L. Kringelbach, N. Jenkinson, S. L. F. Owen and T. Z. A""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/audit/SAN9AYVR/changed_blocks_after_fallback.json b/audit/SAN9AYVR/changed_blocks_after_fallback.json index 85d96444..69e29ac1 100644 --- a/audit/SAN9AYVR/changed_blocks_after_fallback.json +++ b/audit/SAN9AYVR/changed_blocks_after_fallback.json @@ -1321,7 +1321,7 @@ { "block_id": "p33:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1366,7 +1366,7 @@ { "block_id": "p37:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1375,7 +1375,7 @@ { "block_id": "p37:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1384,7 +1384,7 @@ { "block_id": "p37:5", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1393,7 +1393,7 @@ { "block_id": "p37:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1402,7 +1402,7 @@ { "block_id": "p37:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1411,7 +1411,7 @@ { "block_id": "p37:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1420,7 +1420,7 @@ { "block_id": "p37:9", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1429,7 +1429,7 @@ { "block_id": "p37:10", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1438,7 +1438,7 @@ { "block_id": "p37:11", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1618,7 +1618,7 @@ { "block_id": "p42:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1636,7 +1636,7 @@ { "block_id": "p42:5", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1645,7 +1645,7 @@ { "block_id": "p42:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1654,7 +1654,7 @@ { "block_id": "p42:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1663,7 +1663,7 @@ { "block_id": "p42:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1771,7 +1771,7 @@ { "block_id": "p45:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1780,7 +1780,7 @@ { "block_id": "p45:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1798,7 +1798,7 @@ { "block_id": "p45:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1807,7 +1807,7 @@ { "block_id": "p45:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1816,7 +1816,7 @@ { "block_id": "p45:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1825,7 +1825,7 @@ { "block_id": "p45:9", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1969,7 +1969,7 @@ { "block_id": "p49:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1978,7 +1978,7 @@ { "block_id": "p49:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1987,7 +1987,7 @@ { "block_id": "p49:5", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -1996,7 +1996,7 @@ { "block_id": "p49:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -2005,7 +2005,7 @@ { "block_id": "p49:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -2014,7 +2014,7 @@ { "block_id": "p49:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -2023,7 +2023,7 @@ { "block_id": "p49:9", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -2239,7 +2239,7 @@ { "block_id": "p50:25", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, @@ -2374,7 +2374,7 @@ { "block_id": "p56:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -2392,7 +2392,7 @@ { "block_id": "p56:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -2410,7 +2410,7 @@ { "block_id": "p56:10", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -2428,7 +2428,7 @@ { "block_id": "p56:12", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -2437,7 +2437,7 @@ { "block_id": "p56:13", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -2455,7 +2455,7 @@ { "block_id": "p56:15", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -2464,7 +2464,7 @@ { "block_id": "p56:16", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3103,7 +3103,7 @@ { "block_id": "p62:3", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3112,7 +3112,7 @@ { "block_id": "p62:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3121,7 +3121,7 @@ { "block_id": "p62:5", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3130,7 +3130,7 @@ { "block_id": "p62:6", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3139,7 +3139,7 @@ { "block_id": "p62:7", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3148,7 +3148,7 @@ { "block_id": "p62:8", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3157,7 +3157,7 @@ { "block_id": "p62:9", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, @@ -3166,7 +3166,7 @@ { "block_id": "p62:10", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "tail_nonref_hold_zone", "pipe_text_len": 0, "role_match": true, diff --git a/audit/SAN9AYVR/coverage_check.json b/audit/SAN9AYVR/coverage_check.json index ab69af8e..1e5820a6 100644 --- a/audit/SAN9AYVR/coverage_check.json +++ b/audit/SAN9AYVR/coverage_check.json @@ -4,15 +4,10 @@ "required_block_ids": [ "p10:10", "p10:11", - "p10:12", "p10:13", "p10:14", "p10:15", - "p10:16", - "p10:19", - "p10:3", "p10:4", - "p10:5", "p10:6", "p10:8", "p10:9", @@ -21,16 +16,9 @@ "p11:3", "p11:5", "p11:6", - "p11:9", - "p13:10", - "p13:8", - "p14:10", - "p14:5", "p14:9", "p16:10", "p16:11", - "p16:12", - "p16:15", "p16:3", "p16:4", "p16:5", @@ -39,9 +27,6 @@ "p16:8", "p16:9", "p17:3", - "p17:4", - "p17:6", - "p18:2", "p18:4", "p19:3", "p1:0", @@ -76,24 +61,16 @@ "p20:13", "p20:14", "p20:15", - "p20:16", - "p20:3", "p20:4", - "p20:5", "p20:6", "p20:7", "p20:8", - "p20:9", - "p23:10", "p23:3", "p23:4", "p23:5", - "p23:6", "p24:10", "p24:11", "p24:12", - "p24:13", - "p24:16", "p24:3", "p24:4", "p24:5", @@ -101,31 +78,21 @@ "p24:7", "p24:8", "p24:9", - "p26:4", "p26:6", "p26:7", "p26:8", - "p26:9", "p28:10", - "p28:11", - "p28:4", - "p28:5", "p28:6", - "p28:7", "p28:8", "p28:9", "p2:10", - "p2:12", "p2:13", "p2:17", "p2:20", - "p2:4", "p2:6", - "p2:8", "p30:10", "p30:11", "p30:12", - "p30:13", "p30:3", "p30:4", "p30:5", @@ -133,16 +100,10 @@ "p30:7", "p30:8", "p30:9", - "p33:5", "p33:6", - "p33:7", "p35:3", - "p35:4", - "p35:6", "p37:10", "p37:11", - "p37:12", - "p37:14", "p37:3", "p37:4", "p37:5", @@ -159,33 +120,21 @@ "p39:16", "p39:17", "p39:18", - "p39:19", - "p39:3", "p39:4", - "p39:5", "p39:6", "p39:7", "p39:8", "p39:9", "p42:3", - "p42:4", "p42:5", "p42:6", "p42:7", "p42:8", - "p42:9", "p44:10", "p44:11", - "p44:12", - "p44:17", - "p44:3", "p44:4", "p44:6", - "p44:7", - "p44:8", "p44:9", - "p45:10", - "p45:12", "p45:3", "p45:4", "p45:5", @@ -193,21 +142,13 @@ "p45:7", "p45:8", "p45:9", - "p47:10", "p47:11", "p47:13", - "p47:14", "p47:15", - "p47:16", "p47:17", "p47:18", - "p47:19", "p47:3", - "p47:6", - "p47:8", "p47:9", - "p49:10", - "p49:13", "p49:3", "p49:4", "p49:5", @@ -215,40 +156,26 @@ "p49:7", "p49:8", "p49:9", - "p4:6", "p4:7", "p4:8", - "p4:9", "p50:10", "p50:11", - "p50:12", "p50:13", - "p50:14", "p50:15", "p50:16", "p50:17", "p50:18", "p50:19", - "p50:20", "p50:21", "p50:22", "p50:23", "p50:24", "p50:25", - "p50:4", - "p50:5", "p50:6", "p50:7", - "p50:8", "p50:9", - "p51:3", - "p51:7", "p53:3", - "p53:4", - "p53:7", "p55:3", - "p55:4", - "p55:6", "p56:0", "p56:1", "p56:10", @@ -258,7 +185,6 @@ "p56:14", "p56:15", "p56:16", - "p56:17", "p56:18", "p56:19", "p56:2", @@ -289,7 +215,6 @@ "p58:3", "p58:4", "p58:5", - "p58:6", "p58:7", "p58:8", "p59:0", @@ -332,11 +257,9 @@ "p61:6", "p61:7", "p61:8", - "p61:9", "p62:0", "p62:1", "p62:10", - "p62:11", "p62:12", "p62:13", "p62:14", @@ -378,7 +301,6 @@ "p65:1", "p65:2", "p65:3", - "p65:4", "p65:5", "p65:6", "p65:7", @@ -412,9 +334,6 @@ "p69:5", "p69:6", "p6:3", - "p6:4", - "p6:5", - "p6:7", "p70:0", "p70:1", "p70:10", @@ -428,11 +347,6 @@ "p70:7", "p70:8", "p70:9", - "p71:10", - "p71:11", - "p71:12", - "p71:13", - "p71:14", "p71:15", "p71:16", "p71:17", @@ -460,11 +374,7 @@ "p71:8", "p71:9", "p7:3", - "p7:4", - "p7:9", - "p8:3", - "p8:4", - "p8:6" + "p8:3" ], "reviewed_block_ids": [ "p10:10", diff --git a/audit/SAN9AYVR/figure_table_ownership_summary.json b/audit/SAN9AYVR/figure_table_ownership_summary.json index 95bb9a9e..c73e32ed 100644 --- a/audit/SAN9AYVR/figure_table_ownership_summary.json +++ b/audit/SAN9AYVR/figure_table_ownership_summary.json @@ -1,9 +1,9 @@ { "figures": { - "matched_count": 30, - "ambiguous_count": 1, - "unresolved_cluster_count": 1, - "unmatched_asset_count": 1, + "matched_count": 31, + "ambiguous_count": 0, + "unresolved_cluster_count": 0, + "unmatched_asset_count": 16, "matched": [ { "figure_number": 1, @@ -388,29 +388,24 @@ ], "page": 65, "match_type": null - } - ], - "ambiguous": [ + }, { "figure_number": 24, "legend_block_id": 3, - "asset_block_ids": [], - "candidate_asset_ids": [], - "page": 51 + "asset_block_ids": [ + 25 + ], + "page": 50, + "match_type": null } ], - "unresolved": [ - { - "figure_number": null, - "asset_block_ids": [], - "page": 50 - } - ] + "ambiguous": [], + "unresolved": [] }, "tables": { "matched_count": 0, "ambiguous_count": 0, - "unmatched_asset_count": 4, + "unmatched_asset_count": 8, "matched": [], "ambiguous": [] } diff --git a/audit/SAN9AYVR/fulltext_block_mapping_summary.json b/audit/SAN9AYVR/fulltext_block_mapping_summary.json index 684c7d23..5b845120 100644 --- a/audit/SAN9AYVR/fulltext_block_mapping_summary.json +++ b/audit/SAN9AYVR/fulltext_block_mapping_summary.json @@ -1,7 +1,7 @@ { - "mappable_block_count": 1552, - "found_count": 1162, - "missing_count": 390, + "mappable_block_count": 1557, + "found_count": 1094, + "missing_count": 463, "rows": [ { "block_id": "p1:0", @@ -16,13 +16,23 @@ { "block_id": "p1:2", "page": 1, - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", - "render_default": false, + "render_default": true, "snippet": "REVIEW ARTICLE", "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p1:3", + "page": 1, + "role": "body_paragraph", + "zone": "frontmatter_main_zone", + "render_default": true, + "snippet": "View Article Online View Journal", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p1:6", "page": 1, @@ -36,9 +46,9 @@ { "block_id": "p1:7", "page": 1, - "role": "unknown_structural", + "role": "authors", "zone": "frontmatter_main_zone", - "render_default": false, + "render_default": true, "snippet": "Ya Huang, †a Kuanming Yao, †a Qiang Zhang, ⑩†a Xingcan Huang, ⑩a Zhenlin Chen, a", "found_in_fulltext": false, "fulltext_offset": -1 @@ -133,6 +143,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p1:23", + "page": 1, + "role": "non_body_insert", + "zone": "body_zone", + "render_default": false, + "snippet": "f monitoring and therapeutic stimulations, and wearable haptic interfaces. He ha", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p1:24", "page": 1, @@ -151,7 +171,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p2:0", @@ -193,6 +213,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p2:4", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "influence neural activity, facilitate muscle contraction, and promote tissue rep", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p2:5", "page": 2, @@ -201,7 +231,7 @@ "render_default": true, "snippet": "Developing bioelectronics for ES hinges on the strategic integration of electric", "found_in_fulltext": true, - "fulltext_offset": 4237 + "fulltext_offset": 2652 }, { "block_id": "p2:7", @@ -216,7 +246,7 @@ { "block_id": "p2:8", "page": 2, - "role": "figure_caption_candidate", + "role": "non_body_insert", "zone": "", "render_default": false, "snippet": "Dr Qiang Zhang is a postdoctoral fellow at the Department of Biomedical Engineer", @@ -246,7 +276,7 @@ { "block_id": "p2:12", "page": 2, - "role": "figure_caption_candidate", + "role": "non_body_insert", "zone": "frontmatter_side_zone", "render_default": false, "snippet": "Xingcan Huang is currently a PhD student at the Department of Biomedical Enginee", @@ -281,7 +311,7 @@ "render_default": true, "snippet": "and microfluidics for wearable electronics.", "found_in_fulltext": true, - "fulltext_offset": 4716 + "fulltext_offset": 3131 }, { "block_id": "p2:18", @@ -303,6 +333,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p2:20", + "page": 2, + "role": "frontmatter_support", + "zone": "body_zone", + "render_default": true, + "snippet": "12 journals. He has published 180 papers in Nature, Nature Materials, Nature Ele", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p2:21", "page": 2, @@ -311,7 +351,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p2:22", @@ -360,8 +400,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Additionally, the bioelectronics must be capable of generating robust electrical", - "found_in_fulltext": true, - "fulltext_offset": 4785 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p3:4", @@ -370,8 +410,18 @@ "zone": "body_zone", "render_default": true, "snippet": "At the cellular level, ES impacts the transmembrane potential (TMP), where a vit", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p3:5", + "page": 3, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Building on these biological and electrical foundational con- cepts, bioelectron", "found_in_fulltext": true, - "fulltext_offset": 7527 + "fulltext_offset": 3200 }, { "block_id": "p3:6", @@ -381,7 +431,7 @@ "render_default": true, "snippet": "Section 4 catalogues a diverse array of materials utilized in bioelectronics for", "found_in_fulltext": true, - "fulltext_offset": 9226 + "fulltext_offset": 4128 }, { "block_id": "p3:7", @@ -391,7 +441,7 @@ "render_default": true, "snippet": "In Section 5, the focus is on ES based bioelectronics for tissue regeneration, m", "found_in_fulltext": true, - "fulltext_offset": 9812 + "fulltext_offset": 4714 }, { "block_id": "p3:8", @@ -401,7 +451,7 @@ "render_default": true, "snippet": "Section 6 delves into neuromodulation via ES, a versatile medical technique that", "found_in_fulltext": true, - "fulltext_offset": 10294 + "fulltext_offset": 5196 }, { "block_id": "p3:9", @@ -411,7 +461,7 @@ "render_default": true, "snippet": "Section 7 highlights ES as an indispensable tool for bio-functional applications", "found_in_fulltext": true, - "fulltext_offset": 10784 + "fulltext_offset": 5686 }, { "block_id": "p3:10", @@ -421,7 +471,7 @@ "render_default": true, "snippet": "Section 8 is the conclusion and outlook with a discussion on the future directio", "found_in_fulltext": true, - "fulltext_offset": 11104 + "fulltext_offset": 6006 }, { "block_id": "p3:11", @@ -431,7 +481,7 @@ "render_default": true, "snippet": "2. Cellular responses to ES", "found_in_fulltext": true, - "fulltext_offset": 11462 + "fulltext_offset": 6364 }, { "block_id": "p3:12", @@ -441,7 +491,7 @@ "render_default": true, "snippet": "Cellular responses to ES bridge the gap between bioelectrical phenomena and cell", "found_in_fulltext": true, - "fulltext_offset": 11490 + "fulltext_offset": 6392 }, { "block_id": "p3:13", @@ -461,7 +511,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p4:0", @@ -500,8 +550,8 @@ "zone": "body_zone", "render_default": true, "snippet": "exists in all living cells, which is regulated through a delicate balance betwee", - "found_in_fulltext": true, - "fulltext_offset": 11627 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:4", @@ -510,8 +560,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.1. Effects of ES on cell behaviors", - "found_in_fulltext": true, - "fulltext_offset": 12383 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p4:5", @@ -521,7 +571,17 @@ "render_default": true, "snippet": "2.1.1. Cell alignment and migration. Guided cell alignment and migration play pi", "found_in_fulltext": true, - "fulltext_offset": 12420 + "fulltext_offset": 6529 + }, + { + "block_id": "p4:6", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "gradients.59,68–70 Conversely, ventricular myocytes, cardiomyocytes, myoblasts, ", + "found_in_fulltext": true, + "fulltext_offset": 8483 }, { "block_id": "p4:7", @@ -533,16 +593,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p4:9", - "page": 4, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 1 The molecular and cellular-level changes activated by ES.", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p4:10", "page": 4, @@ -551,7 +601,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p4:11", @@ -600,8 +650,8 @@ "zone": "body_zone", "render_default": true, "snippet": "and receptors) and interactions with signal transduction pathways (e.g., Wnt/GSK", - "found_in_fulltext": true, - "fulltext_offset": 16037 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p5:4", @@ -610,8 +660,8 @@ "zone": "body_zone", "render_default": true, "snippet": "2.1.2. Cell proliferation and apoptosis. Despite widespread evidence suggesting ", - "found_in_fulltext": true, - "fulltext_offset": 16370 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p5:5", @@ -621,7 +671,17 @@ "render_default": true, "snippet": "2.1.3. Cell differentiation. ES-induced cell differentiation represents a highly", "found_in_fulltext": true, - "fulltext_offset": 18452 + "fulltext_offset": 10792 + }, + { + "block_id": "p5:6", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "the osteogenic lineage rather than cartilage, which is character- ized by increa", + "found_in_fulltext": true, + "fulltext_offset": 13043 }, { "block_id": "p5:7", @@ -631,7 +691,7 @@ "render_default": true, "snippet": "2.1.4. Cell attachment. Cell attachment has been recognized as an important fact", "found_in_fulltext": true, - "fulltext_offset": 20703 + "fulltext_offset": 14228 }, { "block_id": "p5:8", @@ -641,7 +701,7 @@ "render_default": true, "snippet": "2.2. Molecular mechanisms of cellular responses to ES", "found_in_fulltext": true, - "fulltext_offset": 22332 + "fulltext_offset": 15857 }, { "block_id": "p5:9", @@ -651,7 +711,7 @@ "render_default": true, "snippet": "The underlying mechanisms that govern the cellular responses to ES are currently", "found_in_fulltext": true, - "fulltext_offset": 22386 + "fulltext_offset": 15911 }, { "block_id": "p5:10", @@ -671,7 +731,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p6:0", @@ -703,26 +763,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p6:4", - "page": 6, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "c. Redistribution of surface receptors, lipid rafts and actins", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, - { - "block_id": "p6:5", - "page": 6, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 2 Possible mechanisms of cellular responses to ES. (a) Activation of signal", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p6:6", "page": 6, @@ -731,7 +771,17 @@ "render_default": true, "snippet": "subsequently induces the expression of extracellular signal-regulated kinase, p3", "found_in_fulltext": true, - "fulltext_offset": 23017 + "fulltext_offset": 16542 + }, + { + "block_id": "p6:7", + "page": 6, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "by Leppik et al.126 and Zhao et al.129 Altogether, these putative cellular mecha", + "found_in_fulltext": true, + "fulltext_offset": 19042 }, { "block_id": "p6:8", @@ -741,7 +791,7 @@ "render_default": true, "snippet": "2.3. Conventional methods to deliver ES in vitro", "found_in_fulltext": true, - "fulltext_offset": 25521 + "fulltext_offset": 19327 }, { "block_id": "p6:9", @@ -751,7 +801,7 @@ "render_default": true, "snippet": "In most in vitro studies, cells are cultivated in either 2D or 3D microenvironme", "found_in_fulltext": true, - "fulltext_offset": 25570 + "fulltext_offset": 19376 }, { "block_id": "p6:10", @@ -761,7 +811,7 @@ "render_default": true, "snippet": "Compared with direct coupling, capacitive coupling is biologically safer for ES.", "found_in_fulltext": true, - "fulltext_offset": 26971 + "fulltext_offset": 20777 }, { "block_id": "p6:11", @@ -771,7 +821,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p6:12", @@ -813,16 +863,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p7:4", - "page": 7, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 3 Typical ways to deliver ES for cell behavior regulation, including (a) di", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p7:5", "page": 7, @@ -831,7 +871,7 @@ "render_default": true, "snippet": "indirect contact with the medium, this system prevents cells from being exposed ", "found_in_fulltext": true, - "fulltext_offset": 27342 + "fulltext_offset": 21148 }, { "block_id": "p7:6", @@ -841,7 +881,7 @@ "render_default": true, "snippet": "Inductive coupling is another method for in vitro ES, which commonly involves th", "found_in_fulltext": true, - "fulltext_offset": 28230 + "fulltext_offset": 22036 }, { "block_id": "p7:7", @@ -851,7 +891,7 @@ "render_default": true, "snippet": "2.4. 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To m", + "found_in_fulltext": true, + "fulltext_offset": 64178 }, { "block_id": "p16:16", @@ -1991,7 +2061,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p16:17", @@ -2033,16 +2103,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p17:4", - "page": 17, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 8 Common electroactive materials as building blocks for ES systems.", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p17:5", "page": 17, @@ -2051,7 +2111,17 @@ "render_default": true, "snippet": "injection limit, making them highly favorable for ES applications. In addition, ", "found_in_fulltext": true, - "fulltext_offset": 73430 + "fulltext_offset": 65752 + }, + { + "block_id": "p17:6", + "page": 17, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "exhibits a porous structure that is highly permeable to ions, allowing the bulk ", + "found_in_fulltext": true, + "fulltext_offset": 67132 }, { "block_id": "p17:7", @@ -2071,7 +2141,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p18:0", @@ -2093,6 +2163,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p18:2", + "page": 18, + "role": "table_caption", + "zone": "display_zone", + "render_default": true, + "snippet": "Table 1 Recent and representative electroactive materials and their key features", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p18:3", "page": 18, @@ -2121,7 +2201,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p18:6", @@ -2180,8 +2260,8 @@ "zone": "body_zone", "render_default": true, "snippet": "balance the electrical conductivity and modulus of the PED-OT:PSS-based hydrogel", - "found_in_fulltext": true, - "fulltext_offset": 76256 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p19:5", @@ -2191,7 +2271,7 @@ "render_default": true, "snippet": "PANi, a conducting polymer, has attracted significant research interest and exis", "found_in_fulltext": true, - "fulltext_offset": 76655 + "fulltext_offset": 69956 }, { "block_id": "p19:6", @@ -2201,7 +2281,7 @@ "render_default": true, "snippet": "Melanin is a natural polymeric pigment that possesses intrinsic conductive prope", "found_in_fulltext": true, - "fulltext_offset": 77780 + "fulltext_offset": 71081 }, { "block_id": "p19:7", @@ -2211,7 +2291,7 @@ "render_default": true, "snippet": "Carbon-based materials, including graphene and its derivatives, carbon nanotubes", "found_in_fulltext": true, - "fulltext_offset": 78645 + "fulltext_offset": 71946 }, { "block_id": "p19:8", @@ -2231,7 +2311,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p20:0", @@ -2263,46 +2343,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p20:3", - "page": 20, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "a", - "found_in_fulltext": true, - "fulltext_offset": 29 - }, - { - "block_id": "p20:5", - "page": 20, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "b", - "found_in_fulltext": true, - "fulltext_offset": 68 - }, - { - "block_id": "p20:9", - "page": 20, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "e", - "found_in_fulltext": true, - "fulltext_offset": 5 - }, - { - "block_id": "p20:16", - "page": 20, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 9 Electroactive materials. (a) Mixed ionic/electronic conduction in PEDOT:P", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p20:17", "page": 20, @@ -2311,7 +2351,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p20:18", @@ -2360,8 +2400,8 @@ "zone": "body_zone", "render_default": true, "snippet": "electrochemical properties. Their CIC reached 10.34 mC cm⁻² with an expanded CV ", - "found_in_fulltext": true, - "fulltext_offset": 79894 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p21:4", @@ -2370,8 +2410,18 @@ "zone": "body_zone", "render_default": true, "snippet": "MXenes, 2D transition metal carbide nanomaterials, have gained significant atten", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p21:5", + "page": 21, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "aqueous and organic solvents, making them feasible to fabricate robust MXene-bas", "found_in_fulltext": true, - "fulltext_offset": 81421 + "fulltext_offset": 73195 }, { "block_id": "p21:6", @@ -2381,7 +2431,7 @@ "render_default": true, "snippet": "BP is another conductive dopant that has attracted much scientific interest rece", "found_in_fulltext": true, - "fulltext_offset": 83648 + "fulltext_offset": 73321 }, { "block_id": "p21:7", @@ -2391,7 +2441,7 @@ "render_default": true, "snippet": "Apart from the abovementioned electroactive materials, hybrid conducive material", "found_in_fulltext": true, - "fulltext_offset": 84217 + "fulltext_offset": 73890 }, { "block_id": "p21:8", @@ -2401,7 +2451,7 @@ "render_default": true, "snippet": "To summarize, these materials exhibit favorable electrical properties for ES thr", "found_in_fulltext": true, - "fulltext_offset": 86758 + "fulltext_offset": 76431 }, { "block_id": "p21:9", @@ -2421,7 +2471,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p22:0", @@ -2460,8 +2510,8 @@ "zone": "body_zone", "render_default": true, "snippet": "additional characteristics such as mechanical and biological properties, which w", - "found_in_fulltext": true, - "fulltext_offset": 86958 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p22:4", @@ -2470,8 +2520,8 @@ "zone": "body_zone", "render_default": true, "snippet": "4.2. Mechanical properties", - "found_in_fulltext": true, - "fulltext_offset": 87103 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p22:5", @@ -2481,7 +2531,7 @@ "render_default": true, "snippet": "ES electrodes should have rigorous mechanical performances according to their sp", "found_in_fulltext": true, - "fulltext_offset": 87130 + "fulltext_offset": 76631 }, { "block_id": "p22:6", @@ -2491,7 +2541,17 @@ "render_default": true, "snippet": "While the material composition of an ES electrode predominantly determines its m", "found_in_fulltext": true, - "fulltext_offset": 88382 + "fulltext_offset": 77883 + }, + { + "block_id": "p22:7", + "page": 22, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "where PPy is incorporated as the conductive component while silk fibroin is for ", + "found_in_fulltext": true, + "fulltext_offset": 79872 }, { "block_id": "p22:8", @@ -2501,7 +2561,7 @@ "render_default": true, "snippet": "However, these geometric designs as well as addition of different components wit", "found_in_fulltext": true, - "fulltext_offset": 90489 + "fulltext_offset": 80103 }, { "block_id": "p22:9", @@ -2511,7 +2571,7 @@ "render_default": true, "snippet": "It is worth mentioning that many studies have adopted finite element analysis to", "found_in_fulltext": true, - "fulltext_offset": 92433 + "fulltext_offset": 82047 }, { "block_id": "p22:10", @@ -2521,7 +2581,7 @@ "render_default": true, "snippet": "4.3. Adhesion performance", "found_in_fulltext": true, - "fulltext_offset": 92821 + "fulltext_offset": 82435 }, { "block_id": "p22:11", @@ -2531,7 +2591,7 @@ "render_default": true, "snippet": "ES electrodes require robust interfacial integration with the target biological ", "found_in_fulltext": true, - "fulltext_offset": 92847 + "fulltext_offset": 82461 }, { "block_id": "p22:12", @@ -2541,7 +2601,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p22:13", @@ -2583,16 +2643,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p23:6", - "page": 23, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 10 Mechanical properties. (a) A multilayer Au/Cr-PI construction showing ex", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p23:7", "page": 23, @@ -2601,7 +2651,7 @@ "render_default": true, "snippet": "and chemical bonding, the integrated device could conformally contact and stably", "found_in_fulltext": true, - "fulltext_offset": 93884 + "fulltext_offset": 83498 }, { "block_id": "p23:8", @@ -2611,7 +2661,7 @@ "render_default": true, "snippet": "The second strategy to enhance interfacial integration with tissues involves the", "found_in_fulltext": true, - "fulltext_offset": 94263 + "fulltext_offset": 83877 }, { "block_id": "p23:9", @@ -2621,7 +2671,17 @@ "render_default": true, "snippet": "Another promising strategy involves the chemical modification of the substrates ", "found_in_fulltext": true, - "fulltext_offset": 95525 + "fulltext_offset": 85139 + }, + { + "block_id": "p23:10", + "page": 23, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "typically forming pressure-sensitive adhesives. Similar to the abovementioned mi", + "found_in_fulltext": true, + "fulltext_offset": 85261 }, { "block_id": "p23:11", @@ -2631,7 +2691,7 @@ "render_default": true, "snippet": "Controllable tissue adhesiveness is of paramount importance in the development o", "found_in_fulltext": true, - "fulltext_offset": 96654 + "fulltext_offset": 87318 }, { "block_id": "p23:12", @@ -2651,7 +2711,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p24:0", @@ -2683,16 +2743,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p24:13", - "page": 24, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 11 Adhesion and biological properties. (a) (i) A photocurable hydrogel-base", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p24:14", "page": 24, @@ -2701,7 +2751,7 @@ "render_default": true, "snippet": "4.4. Biosafety and biological functions", "found_in_fulltext": true, - "fulltext_offset": 97377 + "fulltext_offset": 88041 }, { "block_id": "p24:15", @@ -2711,7 +2761,17 @@ "render_default": true, "snippet": "Biosafety is a critical consideration for in vivo ES, which is determined by bot", "found_in_fulltext": true, - "fulltext_offset": 97417 + "fulltext_offset": 88081 + }, + { + "block_id": "p24:16", + "page": 24, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "uncontrollable current pulsing, and high access voltage have been shown to induc", + "found_in_fulltext": true, + "fulltext_offset": 88327 }, { "block_id": "p24:17", @@ -2721,7 +2781,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p24:18", @@ -2770,8 +2830,8 @@ "zone": "body_zone", "render_default": true, "snippet": "electrode and the adjacent tissue. To prevent excessive voltage that activates t", - "found_in_fulltext": true, - "fulltext_offset": 98013 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:4", @@ -2780,8 +2840,8 @@ "zone": "frontmatter_side_zone", "render_default": true, "snippet": "The electrode material itself can also affect the compatibility with targeted ti", - "found_in_fulltext": true, - "fulltext_offset": 99189 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p25:5", @@ -2791,7 +2851,17 @@ "render_default": true, "snippet": "To address these biosafety concerns, a feasible approach is to integrate multipl", "found_in_fulltext": true, - "fulltext_offset": 100088 + "fulltext_offset": 88972 + }, + { + "block_id": "p25:6", + "page": 25, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "betaine), are also widely utilized to modify electrode surfaces to form anti-bio", + "found_in_fulltext": true, + "fulltext_offset": 90494 }, { "block_id": "p25:7", @@ -2801,7 +2871,7 @@ "render_default": true, "snippet": "4.5. Biodegradable/bioresorbable properties", "found_in_fulltext": true, - "fulltext_offset": 102001 + "fulltext_offset": 91265 }, { "block_id": "p25:8", @@ -2811,7 +2881,7 @@ "render_default": true, "snippet": "Traditional implanted ES devices require surgical removal after accomplishing th", "found_in_fulltext": true, - "fulltext_offset": 102045 + "fulltext_offset": 91309 }, { "block_id": "p25:9", @@ -2821,7 +2891,7 @@ "render_default": true, "snippet": "The in vivo degradation of bioresorbable polymers involves several representativ", "found_in_fulltext": true, - "fulltext_offset": 102606 + "fulltext_offset": 91870 }, { "block_id": "p25:10", @@ -2831,7 +2901,7 @@ "render_default": true, "snippet": "In general, the degradation of bioresorbable synthetic polymers like polyvinyl a", "found_in_fulltext": true, - "fulltext_offset": 103757 + "fulltext_offset": 93021 }, { "block_id": "p25:11", @@ -2851,7 +2921,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p26:0", @@ -2890,8 +2960,18 @@ "zone": "body_zone", "render_default": true, "snippet": "oxidative reaction, can be used for circuits and electrodes. In addition, silico", - "found_in_fulltext": true, - "fulltext_offset": 104980 + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p26:4", + "page": 26, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "attaching onto the mechanically dynamic heart surface, while concurrently minimi", + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p26:5", @@ -2901,17 +2981,7 @@ "render_default": true, "snippet": "To fulfill the demands of practical applications, the degradation rate of ES dev", "found_in_fulltext": true, - "fulltext_offset": 106336 - }, - { - "block_id": "p26:9", - "page": 26, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 12 Biodegradable properties. (a) Schematic illustrations showing the repres", - "found_in_fulltext": false, - "fulltext_offset": -1 + "fulltext_offset": 94244 }, { "block_id": "p26:10", @@ -2921,7 +2991,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p26:11", @@ -2970,8 +3040,8 @@ "zone": "body_zone", "render_default": true, "snippet": "acid (a hydrophilic unit) to lactic acid (a hydrophobic unit) ratio in PLGA can ", - "found_in_fulltext": true, - "fulltext_offset": 107030 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p27:4", @@ -2980,8 +3050,8 @@ "zone": "body_zone", "render_default": true, "snippet": "4.6. Other key properties", - "found_in_fulltext": true, - "fulltext_offset": 107576 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p27:5", @@ -2991,7 +3061,7 @@ "render_default": true, "snippet": "Breathability assumes a paramount role for development of bioelectronic devices,", "found_in_fulltext": true, - "fulltext_offset": 107602 + "fulltext_offset": 94938 }, { "block_id": "p27:6", @@ -3001,7 +3071,17 @@ "render_default": true, "snippet": "Over recent years, the utilization of electrospun fibers for preparation of ultr", "found_in_fulltext": true, - "fulltext_offset": 108579 + "fulltext_offset": 95915 + }, + { + "block_id": "p27:7", + "page": 27, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "thereby safeguarding the normal operation of the devices.362 It should be emphas", + "found_in_fulltext": true, + "fulltext_offset": 98814 }, { "block_id": "p27:8", @@ -3011,7 +3091,7 @@ "render_default": true, "snippet": "In addition to breathability, the controllable swellability of bioelectronic int", "found_in_fulltext": true, - "fulltext_offset": 111478 + "fulltext_offset": 99920 }, { "block_id": "p27:9", @@ -3021,7 +3101,7 @@ "render_default": true, "snippet": "Stimuli-responsiveness represents a highly desirable and intriguing characterist", "found_in_fulltext": true, - "fulltext_offset": 112556 + "fulltext_offset": 100998 }, { "block_id": "p27:10", @@ -3041,7 +3121,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p28:0", @@ -3080,36 +3160,16 @@ "zone": "body_zone", "render_default": true, "snippet": "films were fabricated using a combination of poly(ethylene oxide) (PEO) and poly", - "found_in_fulltext": true, - "fulltext_offset": 113944 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { - "block_id": "p28:5", + "block_id": "p28:4", "page": 28, - "role": "figure_caption_candidate", + "role": "body_paragraph", "zone": "body_zone", - "render_default": false, - "snippet": "a", - "found_in_fulltext": true, - "fulltext_offset": 29 - }, - { - "block_id": "p28:7", - "page": 28, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "b", - "found_in_fulltext": true, - "fulltext_offset": 68 - }, - { - "block_id": "p28:11", - "page": 28, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 13 Other key properties. (a) (i) A highly integrated breathable bioelectron", + "render_default": true, + "snippet": "involved the utilization of inclusion complex platelets that facilitated the per", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -3121,7 +3181,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p28:13", @@ -3170,8 +3230,8 @@ "zone": "body_zone", "render_default": true, "snippet": "thereby disrupting the PEO crystallites. Subsequent to the contraction phase, th", - "found_in_fulltext": true, - "fulltext_offset": 115206 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p29:4", @@ -3191,7 +3251,7 @@ "render_default": true, "snippet": "5. ES based bioelectronics for tissue engineering", "found_in_fulltext": true, - "fulltext_offset": 116144 + "fulltext_offset": 102440 }, { "block_id": "p29:6", @@ -3201,7 +3261,7 @@ "render_default": true, "snippet": "Tissue engineering is a multidisciplinary field that merges biology with enginee", "found_in_fulltext": true, - "fulltext_offset": 116194 + "fulltext_offset": 102490 }, { "block_id": "p29:7", @@ -3211,7 +3271,7 @@ "render_default": true, "snippet": "5.1. Skin healing", "found_in_fulltext": true, - "fulltext_offset": 117080 + "fulltext_offset": 103376 }, { "block_id": "p29:8", @@ -3221,7 +3281,17 @@ "render_default": true, "snippet": "Skin, as the largest organ in the human body, serves a crucial function in safeg", "found_in_fulltext": true, - "fulltext_offset": 117098 + "fulltext_offset": 103394 + }, + { + "block_id": "p29:9", + "page": 29, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Decades ago, the theory of skin battery and the relationship between skin wounds", + "found_in_fulltext": true, + "fulltext_offset": 104725 }, { "block_id": "p29:10", @@ -3231,7 +3301,7 @@ "render_default": true, "snippet": "According to the differences in current models, commonly used ES methods can be ", "found_in_fulltext": true, - "fulltext_offset": 119399 + "fulltext_offset": 106704 }, { "block_id": "p29:11", @@ -3241,7 +3311,7 @@ "render_default": true, "snippet": "Both unidirectional and bidirectional currents have similar effects on wound hea", "found_in_fulltext": true, - "fulltext_offset": 120344 + "fulltext_offset": 107649 }, { "block_id": "p29:12", @@ -3261,7 +3331,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p30:0", @@ -3293,16 +3363,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p30:13", - "page": 30, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 14 ES for skin healing. (a) ES waveforms of unidirectional current (charge-", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p30:14", "page": 30, @@ -3311,7 +3371,7 @@ "render_default": false, "snippet": "Chem. Soc. 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Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p32:0", @@ -3450,8 +3510,8 @@ "zone": "body_zone", "render_default": true, "snippet": "stability. The combination of multiple sensors and treatments was able to monito", - "found_in_fulltext": true, - "fulltext_offset": 128916 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p32:4", @@ -3460,8 +3520,8 @@ "zone": "body_zone", "render_default": true, "snippet": "5.2. Muscle regeneration", - "found_in_fulltext": true, - "fulltext_offset": 129064 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p32:5", @@ -3471,7 +3531,7 @@ "render_default": true, "snippet": "Muscle tissues are essential elements of an organism, making up more than 50% of", "found_in_fulltext": true, - "fulltext_offset": 129089 + "fulltext_offset": 112823 }, { "block_id": "p32:6", @@ -3481,7 +3541,17 @@ "render_default": true, "snippet": "Conductive biomaterials have shown promise in enhancing the proliferation and di", "found_in_fulltext": true, - "fulltext_offset": 131105 + "fulltext_offset": 114839 + }, + { + "block_id": "p32:7", + "page": 32, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "recently, because they can be effectively delivered to inaccessible sites for tis", + "found_in_fulltext": true, + "fulltext_offset": 117132 }, { "block_id": "p32:8", @@ -3491,7 +3561,7 @@ "render_default": true, "snippet": "In addition to materials that directly interface with muscle tissues to influenc", "found_in_fulltext": true, - "fulltext_offset": 133398 + "fulltext_offset": 118193 }, { "block_id": "p32:9", @@ -3501,7 +3571,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p32:10", @@ -3550,8 +3620,8 @@ "zone": "body_zone", "render_default": true, "snippet": "that are programmed to emit bionic spikes. This approach led to a significant 73", - "found_in_fulltext": true, - "fulltext_offset": 135878 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p33:4", @@ -3560,19 +3630,19 @@ "zone": "body_zone", "render_default": true, "snippet": "The heart circulates blood through the whole body via the contraction of cardiac", - "found_in_fulltext": true, - "fulltext_offset": 136079 - }, - { - "block_id": "p33:7", - "page": 33, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 15 ES for muscle regeneration. (a) Injecting the hydrogel into the damaged ", "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p33:5", + "page": 33, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "explored an innovative approach that involves incorporating Au nanowires (AuNWs)", + "found_in_fulltext": true, + "fulltext_offset": 120673 + }, { "block_id": "p33:8", "page": 33, @@ -3591,7 +3661,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p34:0", @@ -3630,8 +3700,8 @@ "zone": "body_zone", "render_default": true, "snippet": "engineering is the regeneration of smooth muscles, which play a crucial role in ", - "found_in_fulltext": true, - "fulltext_offset": 137101 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p34:4", @@ -3640,8 +3710,8 @@ "zone": "body_zone", "render_default": true, "snippet": "5.3. Bone regeneration", - "found_in_fulltext": true, - "fulltext_offset": 137663 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p34:5", @@ -3651,7 +3721,7 @@ "render_default": true, "snippet": "Bone regeneration is the process of repairing or regenerating damaged or disease", "found_in_fulltext": true, - "fulltext_offset": 137686 + "fulltext_offset": 121328 }, { "block_id": "p34:6", @@ -3661,7 +3731,17 @@ "render_default": true, "snippet": "Similar to the in vitro stimulation platforms, according to the differences in p", "found_in_fulltext": true, - "fulltext_offset": 138971 + "fulltext_offset": 122613 + }, + { + "block_id": "p34:7", + "page": 34, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "also known as capacitive electrodes or plates, to be situated on the skin flanki", + "found_in_fulltext": true, + "fulltext_offset": 124171 }, { "block_id": "p34:8", @@ -3671,7 +3751,7 @@ "render_default": true, "snippet": "For bone ES, the selection of power sources is still a matter that requires sign", "found_in_fulltext": true, - "fulltext_offset": 140947 + "fulltext_offset": 125029 }, { "block_id": "p34:9", @@ -3681,7 +3761,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p34:10", @@ -3723,16 +3803,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p35:4", - "page": 35, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 16 ES for bone regeneration. (a) Classification of ES based bone growth by ", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p35:5", "page": 35, @@ -3743,6 +3813,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p35:6", + "page": 35, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "This was accomplished through the upregulation of endogenous transforming growth", + "found_in_fulltext": true, + "fulltext_offset": 128290 + }, { "block_id": "p35:7", "page": 35, @@ -3761,7 +3841,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p36:0", @@ -3800,8 +3880,8 @@ "zone": "body_zone", "render_default": true, "snippet": "when combined with ES, promoted intracellular calcium enrichment and significant", - "found_in_fulltext": true, - "fulltext_offset": 144444 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p36:4", @@ -3810,8 +3890,8 @@ "zone": "body_zone", "render_default": true, "snippet": "5.4. Nerve regeneration", - "found_in_fulltext": true, - "fulltext_offset": 146062 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p36:5", @@ -3821,7 +3901,7 @@ "render_default": true, "snippet": "Nerve injuries can cause extensive motor, sensory, and autonomic dysfunctions, s", "found_in_fulltext": true, - "fulltext_offset": 146086 + "fulltext_offset": 128711 }, { "block_id": "p36:6", @@ -3831,7 +3911,17 @@ "render_default": true, "snippet": "Optimal nerve recovery is often hindered by factors such as chronic axotomy, chr", "found_in_fulltext": true, - "fulltext_offset": 147404 + "fulltext_offset": 130029 + }, + { + "block_id": "p36:7", + "page": 36, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "the regenerative effects of ES include the promotion of axonal growth through cyc", + "found_in_fulltext": true, + "fulltext_offset": 131451 }, { "block_id": "p36:8", @@ -3841,7 +3931,7 @@ "render_default": true, "snippet": "In clinical practice, a variety of advanced strategies, including precise nerve ", "found_in_fulltext": true, - "fulltext_offset": 148826 + "fulltext_offset": 132496 }, { "block_id": "p36:9", @@ -3851,7 +3941,7 @@ "render_default": true, "snippet": "NGCs are used in combination with ES to treat neural injury, providing physical ", "found_in_fulltext": true, - "fulltext_offset": 150167 + "fulltext_offset": 133837 }, { "block_id": "p36:10", @@ -3861,7 +3951,7 @@ "render_default": true, "snippet": "Cumbersome external percutaneous wiring is an important issue for implantable ES", "found_in_fulltext": true, - "fulltext_offset": 150956 + "fulltext_offset": 134626 }, { "block_id": "p36:11", @@ -3871,7 +3961,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p36:12", @@ -3913,16 +4003,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p37:12", - "page": 37, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 17 ES for nerve regeneration. (a) Neurons and Schwann cells transition into", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p37:13", "page": 37, @@ -3931,7 +4011,17 @@ "render_default": true, "snippet": "circumvent these issues. Generating ES based on the piezoelectric effect of the ", "found_in_fulltext": true, - "fulltext_offset": 151334 + "fulltext_offset": 135004 + }, + { + "block_id": "p37:14", + "page": 37, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Implantation of the device improved neurological deficits in mouse models under ", + "found_in_fulltext": true, + "fulltext_offset": 135510 }, { "block_id": "p37:15", @@ -3951,7 +4041,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p38:0", @@ -3990,8 +4080,8 @@ "zone": "body_zone", "render_default": true, "snippet": "yielded therapeutic outcomes for long-segment peripheral nerve injuries (15 mm d", - "found_in_fulltext": true, - "fulltext_offset": 152392 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p38:4", @@ -4000,8 +4090,18 @@ "zone": "body_zone", "render_default": true, "snippet": "The necessity of secondary surgical interventions for the extraction of implanta", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p38:5", + "page": 38, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "strategy involves the utilization of battery-free electrical stimu- lators, whic", "found_in_fulltext": true, - "fulltext_offset": 154203 + "fulltext_offset": 136553 }, { "block_id": "p38:6", @@ -4011,7 +4111,7 @@ "render_default": true, "snippet": "5.5. Drug delivery", "found_in_fulltext": true, - "fulltext_offset": 156894 + "fulltext_offset": 137651 }, { "block_id": "p38:7", @@ -4021,7 +4121,7 @@ "render_default": true, "snippet": "The field of drug delivery has experienced significant advancements, with the em", "found_in_fulltext": true, - "fulltext_offset": 156913 + "fulltext_offset": 137670 }, { "block_id": "p38:8", @@ -4031,7 +4131,7 @@ "render_default": true, "snippet": "5.5.1. Iontophoresis. Iontophoresis enables the transportation of small molecule", "found_in_fulltext": true, - "fulltext_offset": 157808 + "fulltext_offset": 138565 }, { "block_id": "p38:9", @@ -4041,7 +4141,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p38:10", @@ -4083,36 +4183,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p39:3", - "page": 39, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "a", - "found_in_fulltext": true, - "fulltext_offset": 29 - }, - { - "block_id": "p39:5", - "page": 39, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "b", - "found_in_fulltext": true, - "fulltext_offset": 68 - }, - { - "block_id": "p39:19", - "page": 39, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 18 ES for drug delivery by iontophoresis. (a) The working principle of iont", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p39:20", "page": 39, @@ -4131,7 +4201,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p40:0", @@ -4170,8 +4240,8 @@ "zone": "body_zone", "render_default": true, "snippet": "wound, the skin temperature increased while the resistance of the thermal resist", - "found_in_fulltext": true, - "fulltext_offset": 159140 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p40:4", @@ -4180,8 +4250,18 @@ "zone": "body_zone", "render_default": true, "snippet": "Subsequently, the same group applied a PENG based controllable transdermal drug ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p40:5", + "page": 40, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "efficiency of transdermal molecular penetration and extraction using the MN array,", "found_in_fulltext": true, - "fulltext_offset": 161481 + "fulltext_offset": 139897 }, { "block_id": "p40:6", @@ -4191,7 +4271,7 @@ "render_default": true, "snippet": "Furthermore, integrated closed-loop feedback systems, which combine the strength", "found_in_fulltext": true, - "fulltext_offset": 163455 + "fulltext_offset": 140904 }, { "block_id": "p40:7", @@ -4201,7 +4281,7 @@ "render_default": true, "snippet": "5.5.2. Electroporation. Electroporation has been one of the most commonly used s", "found_in_fulltext": true, - "fulltext_offset": 165733 + "fulltext_offset": 143182 }, { "block_id": "p40:8", @@ -4211,7 +4291,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p40:9", @@ -4260,8 +4340,8 @@ "zone": "body_zone", "render_default": true, "snippet": "delivery by applying high-voltage electrical pulses, which can create temporary ", - "found_in_fulltext": true, - "fulltext_offset": 165867 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p41:4", @@ -4270,8 +4350,18 @@ "zone": "body_zone", "render_default": true, "snippet": "As shown in Fig. 19c, high-voltage pulses were applied on the skin with pulse wi", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p41:5", + "page": 41, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "and notable stretchability was developed, comprising compo- nents such as carbon", "found_in_fulltext": true, - "fulltext_offset": 168608 + "fulltext_offset": 143316 }, { "block_id": "p41:6", @@ -4281,7 +4371,7 @@ "render_default": true, "snippet": "To further break through the skin barrier for drug delivery, MNs have been combi", "found_in_fulltext": true, - "fulltext_offset": 170127 + "fulltext_offset": 144028 }, { "block_id": "p41:7", @@ -4291,7 +4381,7 @@ "render_default": true, "snippet": "6. ES based bioelectronics for neuromodulation", "found_in_fulltext": true, - "fulltext_offset": 172301 + "fulltext_offset": 146202 }, { "block_id": "p41:8", @@ -4301,7 +4391,7 @@ "render_default": true, "snippet": "Neuromodulation via ES is a promising medical technique that activates, suppress", "found_in_fulltext": true, - "fulltext_offset": 172348 + "fulltext_offset": 146249 }, { "block_id": "p41:9", @@ -4321,7 +4411,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p42:0", @@ -4353,26 +4443,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p42:4", - "page": 42, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "b", - "found_in_fulltext": true, - "fulltext_offset": 68 - }, - { - "block_id": "p42:9", - "page": 42, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 19 ES for electroporation. (a) Schematic of a bulk electroporation system. ", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p42:10", "page": 42, @@ -4381,7 +4451,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p42:11", @@ -4430,8 +4500,8 @@ "zone": "body_zone", "render_default": true, "snippet": "targeted ES of nerves or specific brain regions, neuromodulation can influence n", - "found_in_fulltext": true, - "fulltext_offset": 172676 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p43:4", @@ -4440,8 +4510,8 @@ "zone": "body_zone", "render_default": true, "snippet": "6.1. Mechanisms of ES for neuromodulation", - "found_in_fulltext": true, - "fulltext_offset": 175036 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p43:5", @@ -4451,7 +4521,17 @@ "render_default": true, "snippet": "The nervous system comprises numerous neurons, which are the essential units for", "found_in_fulltext": true, - "fulltext_offset": 175078 + "fulltext_offset": 146577 + }, + { + "block_id": "p43:6", + "page": 43, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "ES can directly impact and modulate neural activities, either exciting or inhibi", + "found_in_fulltext": true, + "fulltext_offset": 147648 }, { "block_id": "p43:7", @@ -4461,7 +4541,7 @@ "render_default": true, "snippet": "To understand how to effectively excite a neuron, researchers have developed mat", "found_in_fulltext": true, - "fulltext_offset": 177002 + "fulltext_offset": 149397 }, { "block_id": "p43:8", @@ -4471,7 +4551,7 @@ "render_default": true, "snippet": "From F. Rattay's computational results, the electrical signal propagation along ", "found_in_fulltext": true, - "fulltext_offset": 178093 + "fulltext_offset": 150488 }, { "block_id": "p43:9", @@ -4491,7 +4571,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p44:0", @@ -4523,46 +4603,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p44:3", - "page": 44, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "a", - "found_in_fulltext": true, - "fulltext_offset": 29 - }, - { - "block_id": "p44:7", - "page": 44, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "d", - "found_in_fulltext": true, - "fulltext_offset": 56 - }, - { - "block_id": "p44:8", - "page": 44, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "e", - "found_in_fulltext": true, - "fulltext_offset": 5 - }, - { - "block_id": "p44:12", - "page": 44, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 20 Mechanism of ES on a neuron. (a) Schematic illustration of efferent neur", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p44:13", "page": 44, @@ -4581,7 +4621,7 @@ "render_default": true, "snippet": "The concept of threshold rheobase is intricately linked to the duration of stimu", "found_in_fulltext": true, - "fulltext_offset": 179883 + "fulltext_offset": 152278 }, { "block_id": "p44:15", @@ -4591,7 +4631,7 @@ "render_default": true, "snippet": "6.2. Electrical brain stimulation", "found_in_fulltext": true, - "fulltext_offset": 181155 + "fulltext_offset": 153550 }, { "block_id": "p44:16", @@ -4601,7 +4641,17 @@ "render_default": true, "snippet": "Electrical brain stimulation represents a cutting-edge approach for both therape", "found_in_fulltext": true, - "fulltext_offset": 181189 + "fulltext_offset": 153584 + }, + { + "block_id": "p44:17", + "page": 44, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "regions, this technique can modulate neuronal activity, potentially restoring or", + "found_in_fulltext": true, + "fulltext_offset": 153787 }, { "block_id": "p44:18", @@ -4611,7 +4661,7 @@ "render_default": true, "snippet": "6.2.1. Deep brain stimulation. 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Stimulation induces", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p45:11", "page": 45, @@ -4701,7 +4741,17 @@ "render_default": true, "snippet": "internal segment of the globus pallidus (GPi) are primarily targeted by DBS to m", "found_in_fulltext": true, - "fulltext_offset": 183192 + "fulltext_offset": 155886 + }, + { + "block_id": "p45:12", + "page": 45, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "noticeable when a generalized seizure is purposefully induced during treatment.5", + "found_in_fulltext": true, + "fulltext_offset": 156762 }, { "block_id": "p45:13", @@ -4711,7 +4761,7 @@ "render_default": true, "snippet": "In epilepsy models, ES of specific brain regions like the mammillothalamic tract", "found_in_fulltext": true, - "fulltext_offset": 184068 + "fulltext_offset": 156845 }, { "block_id": "p45:14", @@ -4731,7 +4781,7 @@ "render_default": false, "snippet": "Chem. Soc. 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Deep brain techniques ofte", "found_in_fulltext": true, - "fulltext_offset": 193640 + "fulltext_offset": 163593 + }, + { + "block_id": "p47:6", + "page": 47, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "stimulation, which can inflict brain damage. Transcranial ES (TES) applies elect", + "found_in_fulltext": true, + "fulltext_offset": 163712 }, { "block_id": "p47:7", @@ -4921,57 +4991,7 @@ "render_default": true, "snippet": "tDCS entails applying a steady, low-intensity electrical current to the scalp. T", "found_in_fulltext": true, - "fulltext_offset": 195169 - }, - { - "block_id": "p47:8", - "page": 47, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "a", - "found_in_fulltext": true, - "fulltext_offset": 29 - }, - { - "block_id": "p47:10", - "page": 47, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "b", - "found_in_fulltext": true, - "fulltext_offset": 68 - }, - { - "block_id": "p47:14", - "page": 47, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "d", - "found_in_fulltext": true, - "fulltext_offset": 56 - }, - { - "block_id": "p47:16", - "page": 47, - "role": "figure_caption_candidate", - "zone": "body_zone", - "render_default": false, - "snippet": "e", - "found_in_fulltext": true, - "fulltext_offset": 5 - }, - { - "block_id": "p47:19", - "page": 47, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 22 Transcranial ES. 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The shunting effect du", "found_in_fulltext": true, - "fulltext_offset": 198004 + "fulltext_offset": 167897 + }, + { + "block_id": "p48:7", + "page": 48, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "To tackle this issue, M. Vo¨ro¨slakos and colleagues developed an intersectional", + "found_in_fulltext": true, + "fulltext_offset": 170488 }, { "block_id": "p48:8", @@ -5071,7 +5101,7 @@ "render_default": true, "snippet": "Compared with TES, cortical ES (CES) inserts electrodes directly on/into the cor", "found_in_fulltext": true, - "fulltext_offset": 200595 + "fulltext_offset": 171845 }, { "block_id": "p48:9", @@ -5081,7 +5111,7 @@ "render_default": true, "snippet": "Brain ES can induce sensory experiences, which are linked to the specific brain ", "found_in_fulltext": true, - "fulltext_offset": 201874 + "fulltext_offset": 173124 }, { "block_id": "p48:10", @@ -5091,7 +5121,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p48:11", @@ -5133,16 +5163,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p49:10", - "page": 49, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 23 Electronics for cortical ES. (a) Schematic depiction of a graphene-based", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p49:11", "page": 49, @@ -5161,7 +5181,17 @@ "render_default": true, "snippet": "Traditional invasive electrode arrays for brain stimulation involve risky and in", "found_in_fulltext": true, - "fulltext_offset": 203588 + "fulltext_offset": 174838 + }, + { + "block_id": "p49:13", + "page": 49, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "invasive procedures.610,611 A stent-mounted electrode array has been shown to sa", + "found_in_fulltext": true, + "fulltext_offset": 176481 }, { "block_id": "p49:14", @@ -5181,7 +5211,7 @@ "render_default": false, "snippet": "Chem. Soc. 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The development of a minimally invasive paddle-", - "found_in_fulltext": true, - "fulltext_offset": 213162 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p52:4", @@ -5440,8 +5430,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Developed from the gate control theory introduced by Wall and Melzack in 1965, S", - "found_in_fulltext": true, - "fulltext_offset": 213472 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p52:5", @@ -5451,7 +5441,7 @@ "render_default": true, "snippet": "Besides pain relieving, SCS is also used for achieving functional movements in p", "found_in_fulltext": true, - "fulltext_offset": 215036 + "fulltext_offset": 183806 }, { "block_id": "p52:6", @@ -5461,7 +5451,17 @@ "render_default": true, "snippet": "By stimulating the spinal cord below the level of injury, SCS aims to enhance se", "found_in_fulltext": true, - "fulltext_offset": 216088 + "fulltext_offset": 184858 + }, + { + "block_id": "p52:7", + "page": 52, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "implanted neurostimulator, a multi-electrode paddle lead, and a robotic support ", + "found_in_fulltext": true, + "fulltext_offset": 185525 }, { "block_id": "p52:8", @@ -5471,7 +5471,7 @@ "render_default": true, "snippet": "Lateral lumbosacral SCS enables individuals with lower-limb amputations to perce", "found_in_fulltext": true, - "fulltext_offset": 216970 + "fulltext_offset": 185950 }, { "block_id": "p52:9", @@ -5491,7 +5491,7 @@ "render_default": true, "snippet": "It's important to note that spinal neural stimulation is typically considered af", "found_in_fulltext": true, - "fulltext_offset": 218742 + "fulltext_offset": 187722 }, { "block_id": "p52:11", @@ -5501,7 +5501,7 @@ "render_default": true, "snippet": "6.4. Vagus nerve and peripheral nerve stimulation", "found_in_fulltext": true, - "fulltext_offset": 219250 + "fulltext_offset": 188230 }, { "block_id": "p52:12", @@ -5511,7 +5511,7 @@ "render_default": true, "snippet": "Neuromodulation therapies, including VNS and PNS, utilize electrical impulses to", "found_in_fulltext": true, - "fulltext_offset": 219300 + "fulltext_offset": 188280 }, { "block_id": "p52:13", @@ -5521,7 +5521,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p52:14", @@ -5563,16 +5563,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p53:4", - "page": 53, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 25 Vagus nerve stimulation. (a) Demonstration of the vagal circuitry that c", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p53:5", "page": 53, @@ -5591,7 +5581,17 @@ "render_default": true, "snippet": "Vagal circuitry serves as a bidirectional communication pathway between the cent", "found_in_fulltext": true, - "fulltext_offset": 220520 + "fulltext_offset": 189500 + }, + { + "block_id": "p53:7", + "page": 53, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "effects and potentially restoring autonomic balance by reducing pro-inflammatory ", + "found_in_fulltext": true, + "fulltext_offset": 190514 }, { "block_id": "p53:8", @@ -5601,7 +5601,7 @@ "render_default": true, "snippet": "Studies have shown that VNS aids in rebalancing parasympathetic and sympathetic ", "found_in_fulltext": true, - "fulltext_offset": 221534 + "fulltext_offset": 190760 }, { "block_id": "p53:9", @@ -5621,7 +5621,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p54:0", @@ -5660,8 +5660,8 @@ "zone": "body_zone", "render_default": true, "snippet": "inflammation and improving gastrointestinal function in IBD, based on animal stu", - "found_in_fulltext": true, - "fulltext_offset": 222519 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p54:4", @@ -5670,8 +5670,8 @@ "zone": "body_zone", "render_default": true, "snippet": "Transcutaneous VNS (tVNS) offers a promising non-invasive alternative to invasiv", - "found_in_fulltext": true, - "fulltext_offset": 224045 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p54:5", @@ -5681,7 +5681,7 @@ "render_default": true, "snippet": "There are some types of electrodes commonly used for vagus and peripheral nerve ", "found_in_fulltext": true, - "fulltext_offset": 225315 + "fulltext_offset": 191745 }, { "block_id": "p54:6", @@ -5691,7 +5691,17 @@ "render_default": true, "snippet": "Both the vagus nerves and peripheral nerves have a similar narrow and elongated ", "found_in_fulltext": true, - "fulltext_offset": 225824 + "fulltext_offset": 192254 + }, + { + "block_id": "p54:7", + "page": 54, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "like the Livanovar stimulator, features a compact, battery-operated stimulator, ", + "found_in_fulltext": true, + "fulltext_offset": 194120 }, { "block_id": "p54:8", @@ -5701,7 +5711,7 @@ "render_default": true, "snippet": "Fig. 26c addresses the challenge of designing self-rolled neural interfaces that", "found_in_fulltext": true, - "fulltext_offset": 227690 + "fulltext_offset": 195864 }, { "block_id": "p54:9", @@ -5711,7 +5721,7 @@ "render_default": true, "snippet": "To address the issues faced by traditional bioelectronic devices, which are unsu", "found_in_fulltext": true, - "fulltext_offset": 228343 + "fulltext_offset": 196517 }, { "block_id": "p54:10", @@ -5721,7 +5731,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p54:11", @@ -5763,16 +5773,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p55:4", - "page": 55, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 26 Bioelectronics for vagus nerve and peripheral nerve stimulation. (a) Pho", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p55:5", "page": 55, @@ -5781,7 +5781,17 @@ "render_default": true, "snippet": "PNS and VNS have emerged as revolutionary approaches in the treatment of various", "found_in_fulltext": true, - "fulltext_offset": 229629 + "fulltext_offset": 197803 + }, + { + "block_id": "p55:6", + "page": 55, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "patients with sensory deficits. Through precise intervention, PNS and VNS stand ", + "found_in_fulltext": true, + "fulltext_offset": 198527 }, { "block_id": "p55:7", @@ -5791,7 +5801,7 @@ "render_default": true, "snippet": "7. ES based bioelectronics for other applications", "found_in_fulltext": true, - "fulltext_offset": 230590 + "fulltext_offset": 198998 }, { "block_id": "p55:8", @@ -5801,7 +5811,7 @@ "render_default": true, "snippet": "ES has become a versatile tool in biofunctional applications, offering a bridge ", "found_in_fulltext": true, - "fulltext_offset": 230640 + "fulltext_offset": 199048 }, { "block_id": "p55:9", @@ -5821,7 +5831,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p56:0", @@ -5860,46 +5870,16 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "technology can be employed to regulate heart rhythms in pacemakers, facilitate m", - "found_in_fulltext": true, - "fulltext_offset": 230873 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { - "block_id": "p56:5", + "block_id": "p56:4", "page": 56, - "role": "figure_caption_candidate", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", - "render_default": false, - "snippet": "a", - "found_in_fulltext": true, - "fulltext_offset": 29 - }, - { - "block_id": "p56:9", - "page": 56, - "role": "figure_caption_candidate", - "zone": "tail_nonref_hold_zone", - "render_default": false, - "snippet": "b", - "found_in_fulltext": true, - "fulltext_offset": 68 - }, - { - "block_id": "p56:14", - "page": 56, - "role": "figure_caption_candidate", - "zone": "tail_nonref_hold_zone", - "render_default": false, - "snippet": "d", - "found_in_fulltext": true, - "fulltext_offset": 56 - }, - { - "block_id": "p56:17", - "page": 56, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 27 Pacemaker. (a) This bioelectronic device is affixed to the epicardium us", + "render_default": true, + "snippet": "biological processes, thus holding the promise of improved quality of life for i", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -5911,7 +5891,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p56:19", @@ -5960,8 +5940,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "7.1. Pacemakers", - "found_in_fulltext": true, - "fulltext_offset": 231479 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p57:4", @@ -5970,8 +5950,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Pacemakers, through the delivery of electrical impulses to the heart muscle, hav", - "found_in_fulltext": true, - "fulltext_offset": 231495 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p57:5", @@ -5981,7 +5961,7 @@ "render_default": true, "snippet": "Cardiomyocytes naturally produce electrical impulses that initiate in the sinoat", "found_in_fulltext": true, - "fulltext_offset": 232287 + "fulltext_offset": 199332 }, { "block_id": "p57:6", @@ -5991,7 +5971,7 @@ "render_default": true, "snippet": "Implantable pacemakers require materials that ensure stability and biocompatibil", "found_in_fulltext": true, - "fulltext_offset": 233141 + "fulltext_offset": 200186 }, { "block_id": "p57:7", @@ -6001,7 +5981,17 @@ "render_default": true, "snippet": "Biodegradable pacemakers are a groundbreaking advancement in temporary cardiac p", "found_in_fulltext": true, - "fulltext_offset": 234539 + "fulltext_offset": 201584 + }, + { + "block_id": "p57:8", + "page": 57, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "glycolic acids.671 Mg is also used, particularly for electrodes, because of its ", + "found_in_fulltext": true, + "fulltext_offset": 202537 }, { "block_id": "p57:9", @@ -6011,7 +6001,7 @@ "render_default": true, "snippet": "The success of implantable pacemakers relies heavily on stable power sources, su", "found_in_fulltext": true, - "fulltext_offset": 235492 + "fulltext_offset": 203178 }, { "block_id": "p57:10", @@ -6021,7 +6011,7 @@ "render_default": true, "snippet": "7.2. Pain block", "found_in_fulltext": true, - "fulltext_offset": 237587 + "fulltext_offset": 205273 }, { "block_id": "p57:11", @@ -6031,7 +6021,7 @@ "render_default": true, "snippet": "Pain is a complex bodily response with both sensory and emotional components, tr", "found_in_fulltext": true, - "fulltext_offset": 237603 + "fulltext_offset": 205289 }, { "block_id": "p57:12", @@ -6051,7 +6041,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p58:0", @@ -6090,16 +6080,16 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "by Melzack and Wall, who offered a physiological explanation for its effectivene", - "found_in_fulltext": true, - "fulltext_offset": 238439 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { - "block_id": "p58:6", + "block_id": "p58:4", "page": 58, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 28 Pain block. (a) Commonly targeted locations for ES used in blocking pain", + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "TENS is a non-invasive technique that uses a portable pulse generator and adhesi", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -6111,7 +6101,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p58:8", @@ -6170,8 +6160,18 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "When placing TENS electrodes, ensure that they are applied to healthy, sensate s", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p59:5", + "page": 59, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "the electrodes along the main nerves proximal to the pain, paravertebrally at sp", "found_in_fulltext": true, - "fulltext_offset": 242668 + "fulltext_offset": 206176 }, { "block_id": "p59:6", @@ -6181,7 +6181,7 @@ "render_default": true, "snippet": "Percutaneous electrical nerve stimulation (PENS) is an invasive form of pain man", "found_in_fulltext": true, - "fulltext_offset": 243364 + "fulltext_offset": 206594 }, { "block_id": "p59:7", @@ -6191,7 +6191,7 @@ "render_default": true, "snippet": "Compared with PENS, invasive cuff-shaped nerve electrodes attach directly to per", "found_in_fulltext": true, - "fulltext_offset": 245528 + "fulltext_offset": 208758 }, { "block_id": "p59:8", @@ -6211,7 +6211,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p60:0", @@ -6250,8 +6250,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "electrodes were developed to avoid secondary surgical procedures for electrode r", - "found_in_fulltext": true, - "fulltext_offset": 246470 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p60:4", @@ -6260,8 +6260,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "ES of peripheral nerves is a non-drug approach to pain management that uses low-", - "found_in_fulltext": true, - "fulltext_offset": 247248 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p60:5", @@ -6271,7 +6271,7 @@ "render_default": true, "snippet": "7.3. Tremor reduction", "found_in_fulltext": true, - "fulltext_offset": 247820 + "fulltext_offset": 209704 }, { "block_id": "p60:6", @@ -6281,7 +6281,7 @@ "render_default": true, "snippet": "Tremor is an involuntary, rhythmic oscillation of muscle, resulting in tremulous", "found_in_fulltext": true, - "fulltext_offset": 247842 + "fulltext_offset": 209726 }, { "block_id": "p60:7", @@ -6291,7 +6291,17 @@ "render_default": true, "snippet": "Tremor reduction through peripheral ES employs two main strategies: functional E", "found_in_fulltext": true, - "fulltext_offset": 249432 + "fulltext_offset": 211316 + }, + { + "block_id": "p60:8", + "page": 60, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "management include employing FES to activate antagonistic muscle forces, stimula", + "found_in_fulltext": true, + "fulltext_offset": 211683 }, { "block_id": "p60:9", @@ -6301,7 +6311,7 @@ "render_default": true, "snippet": "FES represents a therapeutic modality of neuromuscular ES designed to facilitate", "found_in_fulltext": true, - "fulltext_offset": 250091 + "fulltext_offset": 212277 }, { "block_id": "p60:10", @@ -6311,7 +6321,7 @@ "render_default": true, "snippet": "Afferent pathway ES offers a therapeutic strategy distinct from traditional FES ", "found_in_fulltext": true, - "fulltext_offset": 251255 + "fulltext_offset": 213441 }, { "block_id": "p60:11", @@ -6321,7 +6331,7 @@ "render_default": true, "snippet": "In addition to stimulating peripheral nerves, DBS targeting the STN is a recogni", "found_in_fulltext": true, - "fulltext_offset": 252308 + "fulltext_offset": 214494 }, { "block_id": "p60:12", @@ -6331,7 +6341,7 @@ "render_default": true, "snippet": "7.4. Sensory modulation", "found_in_fulltext": true, - "fulltext_offset": 252968 + "fulltext_offset": 215154 }, { "block_id": "p60:13", @@ -6341,7 +6351,7 @@ "render_default": true, "snippet": "ES, as both a therapeutic modality and an enhancement technology, introduces nov", "found_in_fulltext": true, - "fulltext_offset": 252992 + "fulltext_offset": 215178 }, { "block_id": "p60:14", @@ -6351,7 +6361,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p60:15", @@ -6393,16 +6403,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p61:9", - "page": 61, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 29 Tremor reduction. (a) The underlying mechanism by which ES can mitigate ", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p61:10", "page": 61, @@ -6411,7 +6411,17 @@ "render_default": true, "snippet": "spectrum of human sensory experiences. This technique leverages precise electric", "found_in_fulltext": true, - "fulltext_offset": 253119 + "fulltext_offset": 215305 + }, + { + "block_id": "p61:11", + "page": 61, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "encompassing auditory, visual, olfactory, taste, and tactile modalities.715,716", + "found_in_fulltext": true, + "fulltext_offset": 215760 }, { "block_id": "p61:12", @@ -6421,7 +6431,7 @@ "render_default": true, "snippet": "7.4.1. Auditory. ES has significantly advanced the field of hearing, particularl", "found_in_fulltext": true, - "fulltext_offset": 253574 + "fulltext_offset": 215840 }, { "block_id": "p61:13", @@ -6441,7 +6451,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p62:0", @@ -6473,16 +6483,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p62:11", - "page": 62, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 30 Auditory, visual, smell and taste modulation by ES. (a) Auditory modulat", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p62:12", "page": 62, @@ -6491,7 +6491,17 @@ "render_default": true, "snippet": "nonfunctional hair cells by transforming sound signals into electrical impulses ", "found_in_fulltext": true, - "fulltext_offset": 253881 + "fulltext_offset": 216147 + }, + { + "block_id": "p62:13", + "page": 62, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "and minimal interference with the surrounding tissues. Electrode arrays are usua", + "found_in_fulltext": true, + "fulltext_offset": 216682 }, { "block_id": "p62:14", @@ -6501,7 +6511,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p62:15", @@ -6550,8 +6560,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Cochlear implantation often faces challenges such as inflammatory responses, fib", - "found_in_fulltext": true, - "fulltext_offset": 254980 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p63:4", @@ -6560,8 +6570,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Advancements in cochlear implant technology have included improved insertion tec", - "found_in_fulltext": true, - "fulltext_offset": 256680 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p63:5", @@ -6571,7 +6581,7 @@ "render_default": true, "snippet": "7.4.2. Vision. In visual rehabilitation, ES is a key technique in activating ret", "found_in_fulltext": true, - "fulltext_offset": 257313 + "fulltext_offset": 217755 }, { "block_id": "p63:6", @@ -6581,7 +6591,17 @@ "render_default": true, "snippet": "Retinal implants using ES are gaining favor in clinical trials due to their abil", "found_in_fulltext": true, - "fulltext_offset": 258318 + "fulltext_offset": 218760 + }, + { + "block_id": "p63:7", + "page": 63, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "significant improvements in the daily activities and mobility of 72% of trial pa", + "found_in_fulltext": true, + "fulltext_offset": 219021 }, { "block_id": "p63:8", @@ -6591,7 +6611,7 @@ "render_default": true, "snippet": "Stimulating the optic nerve is an effective approach that bypasses the complex r", "found_in_fulltext": true, - "fulltext_offset": 259149 + "fulltext_offset": 220209 }, { "block_id": "p63:9", @@ -6601,7 +6621,7 @@ "render_default": true, "snippet": "ES has witnessed considerable advancements in the realm of vision restoration an", "found_in_fulltext": true, - "fulltext_offset": 260705 + "fulltext_offset": 221765 }, { "block_id": "p63:10", @@ -6611,7 +6631,7 @@ "render_default": true, "snippet": "7.4.3. Olfaction and taste. Olfaction and taste are critical chemical senses tha", "found_in_fulltext": true, - "fulltext_offset": 261514 + "fulltext_offset": 222574 }, { "block_id": "p63:11", @@ -6631,7 +6651,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p64:0", @@ -6670,8 +6690,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Electrical olfactory stimulation is an incipient technological frontier with the", - "found_in_fulltext": true, - "fulltext_offset": 262086 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p64:4", @@ -6680,8 +6700,8 @@ "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "ES is a burgeoning area of research for mimicking or restoring the sense of tast", - "found_in_fulltext": true, - "fulltext_offset": 263565 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p64:5", @@ -6691,7 +6711,7 @@ "render_default": true, "snippet": "7.4.4. Haptics. Tactile afferents in the hand transmit details regarding the phy", "found_in_fulltext": true, - "fulltext_offset": 264471 + "fulltext_offset": 223146 }, { "block_id": "p64:6", @@ -6701,7 +6721,17 @@ "render_default": true, "snippet": "Skin electronics and TENS are fascinating aspects of human-machine interface tec", "found_in_fulltext": true, - "fulltext_offset": 265465 + "fulltext_offset": 224140 + }, + { + "block_id": "p64:7", + "page": 64, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "work by delivering safe, low-level electrical currents that stimu- late the cuta", + "found_in_fulltext": true, + "fulltext_offset": 225809 }, { "block_id": "p64:8", @@ -6711,7 +6741,7 @@ "render_default": true, "snippet": "Implanted peripheral nerve interfaces could enable individuals with limb amputat", "found_in_fulltext": true, - "fulltext_offset": 267134 + "fulltext_offset": 227280 }, { "block_id": "p64:9", @@ -6721,7 +6751,7 @@ "render_default": true, "snippet": "The development of implantable devices has long faced the issue of establishing ", "found_in_fulltext": true, - "fulltext_offset": 268267 + "fulltext_offset": 228413 }, { "block_id": "p64:10", @@ -6731,7 +6761,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p64:11", @@ -6773,16 +6803,6 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, - { - "block_id": "p65:4", - "page": 65, - "role": "figure_caption_candidate", - "zone": "display_zone", - "render_default": false, - "snippet": "Fig. 31 Haptic modulation and human machine interfaces. (a) A schematic graph sh", - "found_in_fulltext": false, - "fulltext_offset": -1 - }, { "block_id": "p65:5", "page": 65, @@ -6791,7 +6811,7 @@ "render_default": true, "snippet": "provides sensory feedback via neurostimulation, improving the prosthetic limb's ", "found_in_fulltext": true, - "fulltext_offset": 269152 + "fulltext_offset": 229298 }, { "block_id": "p65:6", @@ -6801,7 +6821,17 @@ "render_default": true, "snippet": "An ideal prosthetic replacement should provide the user with natural-like sensat", "found_in_fulltext": true, - "fulltext_offset": 269453 + "fulltext_offset": 229599 + }, + { + "block_id": "p65:7", + "page": 65, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "decoding of user intent and delivery of sensory feedback.618,781 While periphera", + "found_in_fulltext": true, + "fulltext_offset": 230251 }, { "block_id": "p65:8", @@ -6821,7 +6851,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p66:0", @@ -6843,6 +6873,16 @@ "found_in_fulltext": false, "fulltext_offset": -1 }, + { + "block_id": "p66:2", + "page": 66, + "role": "table_caption", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "Table 2 ES based bioelectronics for different biomedical applications", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, { "block_id": "p66:3", "page": 66, @@ -6861,7 +6901,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p66:5", @@ -6904,12 +6944,12 @@ "fulltext_offset": -1 }, { - "block_id": "p67:4", + "block_id": "p67:3", "page": 67, - "role": "media_asset", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "render_default": true, - "snippet": "
typesBiomedical applicationDevice type", + "snippet": "Table 2 (continued)", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -6931,7 +6971,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p68:0", @@ -6964,12 +7004,12 @@ "fulltext_offset": -1 }, { - "block_id": "p68:4", + "block_id": "p68:3", "page": 68, - "role": "media_asset", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "render_default": true, - "snippet": "
TypesBiomedical applicationDevice type", + "snippet": "Table 2 (continued)", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -6981,7 +7021,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p68:6", @@ -7024,12 +7064,12 @@ "fulltext_offset": -1 }, { - "block_id": "p69:4", + "block_id": "p69:3", "page": 69, - "role": "media_asset", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "render_default": true, - "snippet": "
TypesBiomedical applicationDevice type", + "snippet": "Table 2 (continued)", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -7051,7 +7091,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p70:0", @@ -7084,12 +7124,12 @@ "fulltext_offset": -1 }, { - "block_id": "p70:4", + "block_id": "p70:3", "page": 70, - "role": "media_asset", + "role": "table_caption", "zone": "tail_nonref_hold_zone", "render_default": true, - "snippet": "
TypesDevice typeES parametersES channe", + "snippet": "Table 2 (continued)", "found_in_fulltext": false, "fulltext_offset": -1 }, @@ -7111,7 +7151,7 @@ "render_default": true, "snippet": "Advancements in ES technology are continually expanding the horizons of human se", "found_in_fulltext": true, - "fulltext_offset": 270685 + "fulltext_offset": 231310 }, { "block_id": "p70:7", @@ -7121,7 +7161,7 @@ "render_default": true, "snippet": "8. Conclusion and outlook", "found_in_fulltext": true, - "fulltext_offset": 271066 + "fulltext_offset": 231691 }, { "block_id": "p70:8", @@ -7131,7 +7171,7 @@ "render_default": true, "snippet": "In this review, we have explored the intricate mechanisms and diverse applicatio", "found_in_fulltext": true, - "fulltext_offset": 271092 + "fulltext_offset": 231717 }, { "block_id": "p70:9", @@ -7141,7 +7181,7 @@ "render_default": true, "snippet": "The future of ES is set to expand with advancements in bioelectronics, materials", "found_in_fulltext": true, - "fulltext_offset": 272801 + "fulltext_offset": 233426 }, { "block_id": "p70:10", @@ -7151,7 +7191,7 @@ "render_default": true, "snippet": "Looking ahead, future advancements in bioelectronics for ES are expected to bene", "found_in_fulltext": true, - "fulltext_offset": 273356 + "fulltext_offset": 233981 }, { "block_id": "p70:11", @@ -7161,7 +7201,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 }, { "block_id": "p70:12", @@ -7210,8 +7250,8 @@ "zone": "body_zone", "render_default": true, "snippet": "materials science. The development of biocompatible, flexible, and highly conduc", - "found_in_fulltext": true, - "fulltext_offset": 273519 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p71:4", @@ -7220,8 +7260,8 @@ "zone": "body_zone", "render_default": true, "snippet": "As our understanding of the bioelectrical underpinnings of diseases advances, ES", - "found_in_fulltext": true, - "fulltext_offset": 274093 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p71:5", @@ -7231,7 +7271,7 @@ "render_default": true, "snippet": "The integration of ES devices with wireless technologies and the Internet of Med", "found_in_fulltext": true, - "fulltext_offset": 274702 + "fulltext_offset": 234144 }, { "block_id": "p71:6", @@ -7241,7 +7281,7 @@ "render_default": true, "snippet": "As ES technologies advance and become more popular in routine clinical practices", "found_in_fulltext": true, - "fulltext_offset": 275229 + "fulltext_offset": 234671 }, { "block_id": "p71:7", @@ -7251,67 +7291,77 @@ "render_default": true, "snippet": "ES stands as a dynamic and versatile tool in bioelectronics, poised to make sign", "found_in_fulltext": true, - "fulltext_offset": 275808 + "fulltext_offset": 235250 }, { "block_id": "p71:8", "page": 71, - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "Data availability", "found_in_fulltext": true, - "fulltext_offset": 277253 + "fulltext_offset": 235963 }, { "block_id": "p71:9", "page": 71, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "render_default": true, "snippet": "This review does not include any new research data generated by the authors. All", "found_in_fulltext": true, - "fulltext_offset": 277273 + "fulltext_offset": 235983 + }, + { + "block_id": "p71:10", + "page": 71, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "with proper authorization from the original sources. The origi- nal sources of a", + "found_in_fulltext": true, + "fulltext_offset": 236239 }, { "block_id": "p71:11", "page": 71, - "role": "backmatter_heading", + "role": "subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Conflicts of interest", "found_in_fulltext": true, - "fulltext_offset": 276521 + "fulltext_offset": 236378 }, { "block_id": "p71:12", "page": 71, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "There are no conflicts to declare.", "found_in_fulltext": true, - "fulltext_offset": 276545 + "fulltext_offset": 236400 }, { "block_id": "p71:13", "page": 71, - "role": "backmatter_heading", + "role": "sub_subsection_heading", "zone": "body_zone", "render_default": true, "snippet": "Acknowledgements", "found_in_fulltext": true, - "fulltext_offset": 276582 + "fulltext_offset": 236437 }, { "block_id": "p71:14", "page": 71, - "role": "backmatter_body", + "role": "body_paragraph", "zone": "body_zone", "render_default": true, "snippet": "This work was supported by the Research Grants Council of the Hong Kong Special ", "found_in_fulltext": true, - "fulltext_offset": 276601 + "fulltext_offset": 236456 }, { "block_id": "p71:15", @@ -7321,7 +7371,7 @@ "render_default": true, "snippet": "References", "found_in_fulltext": true, - "fulltext_offset": 277532 + "fulltext_offset": 237109 }, { "block_id": "p71:16", @@ -7331,7 +7381,7 @@ "render_default": true, "snippet": "1 J. 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Intell., 2022, 4, 893.", "found_in_fulltext": true, - "fulltext_offset": 330898 + "fulltext_offset": 288955 }, { "block_id": "p81:35", @@ -15441,7 +15491,7 @@ "render_default": true, "snippet": "777 L. E. Osborn, et al., Sci. Rob., 2018, 3, eaat3818.", "found_in_fulltext": true, - "fulltext_offset": 330952 + "fulltext_offset": 289009 }, { "block_id": "p81:36", @@ -15451,7 +15501,7 @@ "render_default": true, "snippet": "778 D. W. Tan, et al., Sci. Transl. Med., 2014, 6, 257ra138.", "found_in_fulltext": true, - "fulltext_offset": 331008 + "fulltext_offset": 289065 }, { "block_id": "p81:37", @@ -15461,7 +15511,7 @@ "render_default": true, "snippet": "779 M. Ortiz-Catalan, B. Håkansson and R. Brånemark, Sci. Transl. Med., 2014, 6,", "found_in_fulltext": true, - "fulltext_offset": 331069 + "fulltext_offset": 289126 }, { "block_id": "p81:38", @@ -15471,7 +15521,7 @@ "render_default": true, "snippet": "780 S. Raspopovic, et al., Sci. Transl. Med., 2014, 6, 222ra19.", "found_in_fulltext": true, - "fulltext_offset": 331158 + "fulltext_offset": 289215 }, { "block_id": "p81:39", @@ -15481,7 +15531,7 @@ "render_default": true, "snippet": "781 G. Gu, et al., Nat. Biomed. Eng., 2023, 7, 589.", "found_in_fulltext": true, - "fulltext_offset": 331222 + "fulltext_offset": 289279 }, { "block_id": "p81:40", @@ -15491,7 +15541,7 @@ "render_default": true, "snippet": "782 E. D'Anna, et al., Sci. Rob., 2019, 4, eaau8892.", "found_in_fulltext": true, - "fulltext_offset": 331274 + "fulltext_offset": 289331 }, { "block_id": "p81:41", @@ -15501,7 +15551,7 @@ "render_default": true, "snippet": "783 C. Wu, et al., Adv. Funct. Mater., 2020, 30, 1907378.", "found_in_fulltext": true, - "fulltext_offset": 331327 + "fulltext_offset": 289384 }, { "block_id": "p81:42", @@ -15521,7 +15571,7 @@ "render_default": false, "snippet": "Chem. Soc. Rev.", "found_in_fulltext": true, - "fulltext_offset": 279975 + "fulltext_offset": 239407 } ] } \ No newline at end of file diff --git a/audit/SAN9AYVR/page_risk_summary.json b/audit/SAN9AYVR/page_risk_summary.json index 549ed4ee..f55c3d04 100644 --- a/audit/SAN9AYVR/page_risk_summary.json +++ b/audit/SAN9AYVR/page_risk_summary.json @@ -2,55 +2,49 @@ "pages": [ { "page": 1, - "risk_score": 16, + "risk_score": 12, "risk_reasons": [ "frontmatter_page", "multi_asset_page", - "reader_object_gap", - "hold_threshold", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "frontmatter", - "object_ownership", - "reading_order" + "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, "media_assets": 3, "table_like": 0, "captions": 0, - "hold": 2, - "unknown_structural": 4, + "hold": 0, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } }, { "page": 2, - "risk_score": 12, + "risk_score": 10, "risk_reasons": [ "multi_asset_page", "caption_asset_mismatch", - "reader_object_gap", - "unknown_structural_threshold" + "reader_object_gap" ], "recommended_audit_targets": [ - "body_flow", "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, "media_assets": 4, "table_like": 0, "captions": 2, "hold": 0, - "unknown_structural": 2, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -61,14 +55,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 8, + "body_paragraph": 9, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -82,69 +76,6 @@ "recommended_audit_targets": [ "object_ownership" ], - "counts": { - "body_paragraph": 3, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, - "table_like": 0, - "captions": 1, - "hold": 0, - "unknown_structural": 1, - "matched_figures": 1, - "ambiguous_figures": 0 - } - }, - { - "page": 5, - "risk_score": 0, - "risk_reasons": [], - "recommended_audit_targets": [], - "counts": { - "body_paragraph": 5, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 1, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 6, - "risk_score": 6, - "risk_reasons": [ - "caption_asset_mismatch", - "reader_object_gap" - ], - "recommended_audit_targets": [ - "object_ownership" - ], - "counts": { - "body_paragraph": 3, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, - "table_like": 0, - "captions": 2, - "hold": 0, - "unknown_structural": 1, - "matched_figures": 1, - "ambiguous_figures": 0 - } - }, - { - "page": 7, - "risk_score": 3, - "risk_reasons": [ - "reader_object_gap" - ], - "recommended_audit_targets": [ - "object_ownership" - ], "counts": { "body_paragraph": 4, "reference_item": 0, @@ -153,7 +84,70 @@ "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, + "matched_figures": 1, + "ambiguous_figures": 0 + } + }, + { + "page": 5, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], + "counts": { + "body_paragraph": 6, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 0, + "captions": 0, + "hold": 0, + "unknown_structural": 0, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 6, + "risk_score": 6, + "risk_reasons": [ + "caption_asset_mismatch", + "reader_object_gap" + ], + "recommended_audit_targets": [ + "object_ownership" + ], + "counts": { + "body_paragraph": 4, + "reference_item": 0, + "tail_like": 0, + "media_assets": 1, + "table_like": 0, + "captions": 2, + "hold": 0, + "unknown_structural": 0, + "matched_figures": 1, + "ambiguous_figures": 0 + } + }, + { + "page": 7, + "risk_score": 3, + "risk_reasons": [ + "reader_object_gap" + ], + "recommended_audit_targets": [ + "object_ownership" + ], + "counts": { + "body_paragraph": 5, + "reference_item": 0, + "tail_like": 0, + "media_assets": 1, + "table_like": 0, + "captions": 1, + "hold": 0, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -168,14 +162,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -186,14 +180,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 7, + "body_paragraph": 8, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -210,14 +204,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 3, + "body_paragraph": 4, "reference_item": 0, "tail_like": 0, "media_assets": 9, "table_like": 0, - "captions": 4, + "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -232,14 +226,14 @@ "body_flow" ], "counts": { - "body_paragraph": 8, + "body_paragraph": 9, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 5, + "unknown_structural": 4, "matched_figures": 0, "ambiguous_figures": 0 } @@ -250,7 +244,25 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 0, + "captions": 0, + "hold": 0, + "unknown_structural": 0, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 13, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], + "counts": { + "body_paragraph": 11, "reference_item": 0, "tail_like": 0, "media_assets": 0, @@ -262,28 +274,6 @@ "ambiguous_figures": 0 } }, - { - "page": 13, - "risk_score": 2, - "risk_reasons": [ - "unknown_structural_threshold" - ], - "recommended_audit_targets": [ - "body_flow" - ], - "counts": { - "body_paragraph": 10, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 2, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, { "page": 14, "risk_score": 3, @@ -294,14 +284,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -312,14 +302,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 8, + "body_paragraph": 9, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -336,14 +326,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, "media_assets": 9, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -358,14 +348,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -434,7 +424,7 @@ "tail_like": 0, "media_assets": 10, "table_like": 0, - "captions": 4, + "captions": 1, "hold": 0, "unknown_structural": 0, "matched_figures": 1, @@ -447,14 +437,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -465,14 +455,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -489,14 +479,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 3, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -513,14 +503,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 0, "media_assets": 10, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -531,14 +521,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -555,14 +545,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, "media_assets": 3, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -573,14 +563,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -597,14 +587,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 0, "media_assets": 4, "table_like": 0, - "captions": 3, + "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -615,14 +605,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -675,14 +665,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -696,6 +686,46 @@ "recommended_audit_targets": [ "object_ownership" ], + "counts": { + "body_paragraph": 3, + "reference_item": 0, + "tail_like": 0, + "media_assets": 1, + "table_like": 0, + "captions": 1, + "hold": 0, + "unknown_structural": 0, + "matched_figures": 1, + "ambiguous_figures": 0 + } + }, + { + "page": 34, + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], + "counts": { + "body_paragraph": 5, + "reference_item": 0, + "tail_like": 0, + "media_assets": 0, + "table_like": 0, + "captions": 0, + "hold": 0, + "unknown_structural": 0, + "matched_figures": 0, + "ambiguous_figures": 0 + } + }, + { + "page": 35, + "risk_score": 3, + "risk_reasons": [ + "reader_object_gap" + ], + "recommended_audit_targets": [ + "object_ownership" + ], "counts": { "body_paragraph": 2, "reference_item": 0, @@ -704,47 +734,7 @@ "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, - "matched_figures": 1, - "ambiguous_figures": 0 - } - }, - { - "page": 34, - "risk_score": 0, - "risk_reasons": [], - "recommended_audit_targets": [], - "counts": { - "body_paragraph": 4, - "reference_item": 0, - "tail_like": 0, - "media_assets": 0, - "table_like": 0, - "captions": 0, - "hold": 0, - "unknown_structural": 1, - "matched_figures": 0, - "ambiguous_figures": 0 - } - }, - { - "page": 35, - "risk_score": 3, - "risk_reasons": [ - "reader_object_gap" - ], - "recommended_audit_targets": [ - "object_ownership" - ], - "counts": { - "body_paragraph": 1, - "reference_item": 0, - "tail_like": 0, - "media_assets": 1, - "table_like": 0, - "captions": 1, - "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -755,14 +745,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -779,14 +769,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 0, "media_assets": 9, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -797,14 +787,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -826,7 +816,7 @@ "tail_like": 0, "media_assets": 14, "table_like": 0, - "captions": 3, + "captions": 1, "hold": 0, "unknown_structural": 0, "matched_figures": 1, @@ -839,14 +829,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -857,14 +847,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -886,7 +876,7 @@ "tail_like": 0, "media_assets": 5, "table_like": 0, - "captions": 2, + "captions": 1, "hold": 0, "unknown_structural": 0, "matched_figures": 1, @@ -899,14 +889,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -923,14 +913,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 5, + "body_paragraph": 6, "reference_item": 0, "tail_like": 0, "media_assets": 5, "table_like": 0, - "captions": 4, + "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -947,14 +937,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, "media_assets": 7, "table_like": 1, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -965,14 +955,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 7, + "body_paragraph": 8, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -989,14 +979,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 0, "media_assets": 6, "table_like": 0, - "captions": 5, + "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1007,14 +997,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1031,62 +1021,57 @@ "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, "media_assets": 7, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } }, { "page": 50, - "risk_score": 10, + "risk_score": 7, "risk_reasons": [ "multi_asset_page", - "caption_asset_mismatch", "reader_object_gap" ], "recommended_audit_targets": [ "object_ownership" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 0, "media_assets": 16, "table_like": 0, - "captions": 5, + "captions": 0, "hold": 0, - "unknown_structural": 1, - "matched_figures": 0, + "unknown_structural": 0, + "matched_figures": 1, "ambiguous_figures": 0 } }, { "page": 51, - "risk_score": 3, - "risk_reasons": [ - "reader_object_gap" - ], - "recommended_audit_targets": [ - "object_ownership" - ], + "risk_score": 0, + "risk_reasons": [], + "recommended_audit_targets": [], "counts": { - "body_paragraph": 3, + "body_paragraph": 4, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, - "ambiguous_figures": 1 + "ambiguous_figures": 0 } }, { @@ -1095,14 +1080,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 8, + "body_paragraph": 9, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1117,14 +1102,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 3, + "body_paragraph": 4, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1135,14 +1120,14 @@ "risk_reasons": [], "recommended_audit_targets": [], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 0, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1157,14 +1142,14 @@ "object_ownership" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 0, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1184,14 +1169,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 19, "media_assets": 8, "table_like": 0, - "captions": 4, + "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1207,14 +1192,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 14, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1232,14 +1217,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 8, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1255,14 +1240,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 4, + "body_paragraph": 5, "reference_item": 0, "tail_like": 10, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1278,14 +1263,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 8, + "body_paragraph": 9, "reference_item": 0, "tail_like": 16, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1305,14 +1290,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 14, "media_assets": 6, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1332,14 +1317,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 1, + "body_paragraph": 2, "reference_item": 0, "tail_like": 15, "media_assets": 8, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1355,14 +1340,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 7, + "body_paragraph": 8, "reference_item": 0, "tail_like": 13, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1378,14 +1363,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 6, + "body_paragraph": 7, "reference_item": 0, "tail_like": 12, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1403,14 +1388,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 2, + "body_paragraph": 3, "reference_item": 0, "tail_like": 9, "media_assets": 1, "table_like": 0, "captions": 1, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 1, "ambiguous_figures": 0 } @@ -1441,11 +1426,10 @@ }, { "page": 67, - "risk_score": 10, + "risk_score": 7, "risk_reasons": [ "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap" + "caption_asset_mismatch" ], "recommended_audit_targets": [ "object_ownership" @@ -1454,7 +1438,7 @@ "body_paragraph": 0, "reference_item": 0, "tail_like": 7, - "media_assets": 1, + "media_assets": 0, "table_like": 2, "captions": 1, "hold": 0, @@ -1465,11 +1449,10 @@ }, { "page": 68, - "risk_score": 10, + "risk_score": 7, "risk_reasons": [ "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap" + "caption_asset_mismatch" ], "recommended_audit_targets": [ "object_ownership" @@ -1478,7 +1461,7 @@ "body_paragraph": 0, "reference_item": 0, "tail_like": 7, - "media_assets": 1, + "media_assets": 0, "table_like": 2, "captions": 1, "hold": 0, @@ -1489,11 +1472,10 @@ }, { "page": 69, - "risk_score": 10, + "risk_score": 7, "risk_reasons": [ "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap" + "caption_asset_mismatch" ], "recommended_audit_targets": [ "object_ownership" @@ -1502,7 +1484,7 @@ "body_paragraph": 0, "reference_item": 0, "tail_like": 7, - "media_assets": 1, + "media_assets": 0, "table_like": 2, "captions": 1, "hold": 0, @@ -1513,12 +1495,11 @@ }, { "page": 70, - "risk_score": 14, + "risk_score": 11, "risk_reasons": [ "same_page_boundary", "multi_asset_page", - "caption_asset_mismatch", - "reader_object_gap" + "caption_asset_mismatch" ], "recommended_audit_targets": [ "object_ownership", @@ -1529,7 +1510,7 @@ "body_paragraph": 5, "reference_item": 0, "tail_like": 13, - "media_assets": 1, + "media_assets": 0, "table_like": 2, "captions": 1, "hold": 0, @@ -1552,14 +1533,14 @@ "same_page_boundary" ], "counts": { - "body_paragraph": 5, + "body_paragraph": 9, "reference_item": 18, - "tail_like": 11, + "tail_like": 7, "media_assets": 0, "table_like": 0, "captions": 0, "hold": 0, - "unknown_structural": 1, + "unknown_structural": 0, "matched_figures": 0, "ambiguous_figures": 0 } @@ -1746,54 +1727,7 @@ } ], "selected_pages": [ - 1, - 2, - 4, - 6, - 7, - 8, - 10, - 11, - 13, - 14, - 16, - 17, - 18, - 19, - 20, - 23, - 24, - 26, - 28, - 30, - 33, - 35, - 37, - 39, - 42, - 44, - 45, - 47, 49, - 50, - 51, - 53, - 55, - 56, - 57, - 58, - 59, - 60, - 61, - 62, - 63, - 64, - 65, - 66, - 67, - 68, - 69, - 70, - 71 + 50 ] } \ No newline at end of file diff --git a/audit/TSCKAVIS/audit_report.json b/audit/TSCKAVIS/audit_report.json index 68ef8bfe..0fb8cc19 100644 --- a/audit/TSCKAVIS/audit_report.json +++ b/audit/TSCKAVIS/audit_report.json @@ -5,38 +5,41 @@ "focus": [], "artifact_fingerprint": { "result_json_hash": "sha256:960023f17effc60fe6f5bec944d65acc588bd553e167711d7fef13559662776d", - "meta_json_hash": "sha256:79730904bdc3f89586b25a45307d57130973f56025fe670820c798296666d0ca", - "blocks_raw_hash": "sha256:3f48a5642781223e4f09aa722b912eb4ec77cf4f9843301cdaaa221d5cdb4191", - "structured_blocks_hash": "sha256:9c049ac28f42e46a64cee62b538e32dac59fec580be7a5f82c22b35d19bcd442", - "document_structure_hash": "sha256:a3ee85915a40a70082a5c7c7c6392f200984a93fb640bb5a39621f5393d7132f", - "figure_inventory_hash": "sha256:053ba4adc58043a52a40e17a92570e9f747dac51a74e4f35661b27a22d148adc", - "table_inventory_hash": "sha256:f261e3e18a52246bb6e38539a7724214c701703ce59bfdf20ea5d99a67ca3a0a", - "reader_figures_hash": "sha256:f476763a21c3fabd5b83980820c3ab3536773092e06f0ca51c68d0d40559dedf", + "meta_json_hash": "sha256:c6a07d20577c625bc29c75b203583bee8ba293dd5c0ec2269e21661bc89bc4ae", + "blocks_raw_hash": "sha256:bcc3daaeb6cc49a17c6b6dec6abb12bd698eed866f88ef0c66dbe15be05da6c4", + "structured_blocks_hash": "sha256:5d5203bfb08d6ea2f0b6d37b094ef2b7c47a4cb0fd14fb538b39e9d74b1950d1", + "document_structure_hash": "sha256:bebc7a51d459e4d2fe3455353b24c9456fc353ebed150359027a30fb4df9f9f7", + "figure_inventory_hash": "sha256:6884aa9dc1fbc52ff876301fec1848a228184eb557bc41b1c846cb57386f7d17", + "table_inventory_hash": "sha256:1d5d2054c9a4e15b200ae3e59d751b7dd5378e0278740316509867f7351a5d32", + "reader_figures_hash": "sha256:9405a5c9c3fef7fafd97a75cbbec83d5d7ef5849ab923881fab416d04a572ba1", "resolved_metadata_hash": "sha256:0ac25cc37d43ebd5f03c00d31e8e6a84ab4d94aacb712f667c66229ba424f642", - "fulltext_hash": "sha256:d2c564742e39830a7be7b6afad9f787967c50c66e7bcef2564deb273c85a1c73", - "block_trace_hash": "sha256:b60f52ab8bf156a9de2ad6a4af74a1a9e2ae20de3350fb3b2224e5c68f46abf8", + "fulltext_hash": "sha256:c15eeb0c2fc175ed01856b6e645a71ed16bb46cf3576f26e523c7dda5f1193c5", + "block_trace_hash": "sha256:01308a01d3909c75bc5a90d940a689c4191f3c8cd284edd367d76f9c139d1b8c", "annotated_pages": { "page_001.png": "sha256:c12fc64ec25742cbca120afdcfd7535dbdbdac865a4d8e87189e330ee1117fad", - "page_002.png": "sha256:93c896d64fcbca776f84630e401c14fed5f2c5177ef3c8e13db135d2ee92fdc1", - "page_003.png": "sha256:8557bae293a9c6853bb98031e047786213c0f5b90ac8f609ccbf9aa3421e2511", - "page_004.png": "sha256:7c4ec52122c863471bcfa197c7f6370833c43b260b9e9e89e589c424664305e5", - "page_005.png": "sha256:17acd5be13d1a3c0fb5f1ef432c9b924d92e9175ed7001afd626e2bf2ec76ce5", - "page_006.png": "sha256:594706a0a3928afffadffb70f8b6f505a14817a3cfdbf827f3add9a77f1760e8", - "page_007.png": "sha256:3c9e18a518244504cbfa335eb301020fb01e63467f2f78675f4d40732972a6f6", - "page_008.png": "sha256:45f9f97cac40159ea720e8dec15715f938ec10448b5f80ddb52dbd6e6dfdfdfd", - "page_009.png": "sha256:91880c340fcdc715e27aa283b03e4b5be0e7cc9e89fc7f06df8e48b116d7fa89", - "page_010.png": "sha256:41157f4034f7d4aedd4dc4f72a87ca1c0b340940866e54957d5339eccf121b5f", - "page_011.png": "sha256:0b1ed1ff5747551cc2be4bde175e6af07ebc656fa639f6792393f153c4e9a482", - "page_012.png": "sha256:d9396aeeff8a81b3566a5ff9dbaa04ac78d24b175c3a7c376aee40abdb6943a0", - "page_013.png": "sha256:b9ec7784f0ce2942c11f4f145d30d0fcded824ec4912ac7688b325ed3a58cac9", + "page_002.png": "sha256:f76713246f77c2760877b8eb324e93c8006b3dabf1660737a76907f7a8b82e87", + "page_003.png": "sha256:b3e032a8f527dd4cf77173311d201604aefd22488419daa32d10b167cb69a0db", + "page_004.png": "sha256:300f92fca91120b22d7f3e6a5dc543246de125a9f88c64961bcf4bc528ddaea4", + "page_005.png": "sha256:9691215faeac752aca989c152544a495952f34fa527286e5fa371a79910abcee", + "page_006.png": "sha256:a0f87884c02dc6c9317cf11752ebab94aabf7f32e47a3f16b20a54c9ed87257e", + "page_007.png": "sha256:20dc4881f44201263e52f4cdd2be2d2c5be68f87c167283fe3f894edce2c59f4", + "page_008.png": "sha256:71a27c86762d6e24eb10dac007b63d23169c879bdf080aee2b465a14e56d9238", + "page_009.png": "sha256:73d4cae58a68347e31119749bb22545a84304ae592b3f9391bc887d3a799dd01", + "page_010.png": "sha256:a7a9235d3042f71f4756667ae763c990312ca55fdcd4088cb0be20fd3d05660b", + "page_011.png": "sha256:30ae35d3aa526f983cba33a7da3158d9929514b65f7b350bf9f65fd806c0cfb0", + "page_012.png": "sha256:50684bd0481e5c8e7e3985475efd7cc18d2feda01028a0cc467c6325eebf28dc", + "page_013.png": "sha256:b0c3975c9c4617ce36bd0c27f47f122e4f5ffa15994570499b5fd2427ad2df43", "page_014.png": "sha256:c4c726741b5a3cb3e45ebc99ba188ca043dc9e703454f987e21c01fb39a12171", - "page_015.png": "sha256:7e4768a78597f79a20a0eaaca215bedca6398e7279cbfebdd75a9625f247872e" + "page_015.png": "sha256:784c051e735a7bf05630e1a0d4afae1479b0eab62526ff59c54dfaf8db21650c" } }, "artifact_freshness": { "missing": [], "mismatches": [ - "document_structure older than blocks_structured" + "document_structure older than blocks_structured", + "figure_inventory older than blocks_structured", + "table_inventory older than blocks_structured", + "resolved_metadata older than blocks_structured" ], "annotated_pages_rendered": [ "page_001.png", @@ -63,11 +66,10 @@ 5, 6, 7, - 8, 9, 11, - 12, - 13 + 13, + 15 ], "reviewed_blocks": [ "p1:0", @@ -131,17 +133,6 @@ "p7:6", "p7:7", "p7:8", - "p8:0", - "p8:1", - "p8:2", - "p8:3", - "p8:4", - "p8:5", - "p8:6", - "p8:7", - "p8:8", - "p8:9", - "p8:10", "p9:0", "p9:1", "p9:2", @@ -163,22 +154,6 @@ "p11:6", "p11:7", "p11:8", - "p12:0", - "p12:1", - "p12:2", - "p12:3", - "p12:4", - "p12:5", - "p12:6", - "p12:7", - "p12:8", - "p12:9", - "p12:10", - "p12:11", - "p12:12", - "p12:13", - "p12:14", - "p12:15", "p13:0", "p13:1", "p13:2", @@ -201,287 +176,95 @@ "p13:19", "p13:20", "p13:21", - "p13:22" + "p13:22", + "p15:0", + "p15:1", + "p15:2", + "p15:3", + "p15:4", + "p15:5", + "p15:6", + "p15:7", + "p15:8", + "p15:9", + "p15:10", + "p15:11", + "p15:12", + "p15:13", + "p15:14", + "p15:15", + "p15:16", + "p15:17", + "p15:18", + "p15:19", + "p15:20", + "p15:21", + "p15:22", + "p15:23", + "p15:24", + "p15:25", + "p15:26", + "p15:27", + "p15:28", + "p15:29", + "p15:30", + "p15:31", + "p15:32", + "p15:33", + "p15:34", + "p15:35", + "p15:36", + "p15:37", + "p15:38", + "p15:39", + "p15:40", + "p15:41", + "p15:42", + "p15:43", + "p15:44", + "p15:45", + "p15:46", + "p15:47", + "p15:48", + "p15:49", + "p15:50", + "p15:51", + "p15:52", + "p15:53", + "p15:54", + "p15:55", + "p15:56", + "p15:57", + "p15:58", + "p15:59", + "p15:60", + "p15:61", + "p15:62", + "p15:63", + "p15:64", + "p15:65", + "p15:66", + "p15:67", + "p15:68", + "p15:69", + "p15:70", + "p15:71", + "p15:72", + "p15:73", + "p15:74", + "p15:75" ], "findings": [ { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:11" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", + "category": "same_page_boundary_error", + "severity": "major", + "block_ids": [], + "truth": "body/reference/backmatter boundaries should be explainable at block level", + "pipeline_behavior": "page contains mixed body/reference/tail signals", + "root_cause_hypothesis": "same-page boundary ambiguity", "evidence": { "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:12" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:13" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:14" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:15" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:16" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:17" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:18" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:19" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:20" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:21" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p13:22" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_013.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:0" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:1" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:2" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:3" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:4" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:5" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:6" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" - } - }, - { - "category": "reference_span_error", - "severity": "critical", - "block_ids": [ - "p14:7" - ], - "truth": "block should remain outside the accepted reference span", - "pipeline_behavior": "block appears inside the logical reference reading-order region", - "root_cause_hypothesis": "logical_order_between_reference_members", - "evidence": { - "annotated_page": "annotated_pages/page_014.png", - "artifact": "reference_span_audit.json" + "artifact": "page_risk_summary.json" } }, { @@ -492,7 +275,7 @@ "pipeline_behavior": "page contains mixed body/reference/tail signals", "root_cause_hypothesis": "same-page boundary ambiguity", "evidence": { - "annotated_page": "annotated_pages/page_013.png", + "annotated_page": "annotated_pages/page_015.png", "artifact": "page_risk_summary.json" } }, @@ -508,18 +291,18 @@ "p1:8", "p1:11", "p2:0", + "p2:1", "p2:2", + "p2:9", "p2:14", "p2:15", "p3:0", - "p3:2", + "p3:1", "p3:3", "p3:4", "p4:0", - "p4:2", - "p4:8", - "p5:0", - "p5:11" + "p4:1", + "p4:8" ], "truth": "rendered fulltext should be traceable back to source blocks", "pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output", diff --git a/audit/TSCKAVIS/audit_report.md b/audit/TSCKAVIS/audit_report.md index cf4c29d4..5f0de07e 100644 --- a/audit/TSCKAVIS/audit_report.md +++ b/audit/TSCKAVIS/audit_report.md @@ -2,31 +2,12 @@ - Mode: `high-risk` - Status: `READY` -- Reviewed pages: [1, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13] -- Reviewed blocks: 132 +- Reviewed pages: [1, 3, 4, 5, 6, 7, 9, 11, 13, 15] +- Reviewed blocks: 181 ## Findings -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region -- `critical` `reference_span_error`: block appears inside the logical reference reading-order region +- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals - `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output diff --git a/audit/TSCKAVIS/audit_scope.json b/audit/TSCKAVIS/audit_scope.json index 440380db..0d1b278e 100644 --- a/audit/TSCKAVIS/audit_scope.json +++ b/audit/TSCKAVIS/audit_scope.json @@ -7,11 +7,10 @@ 5, 6, 7, - 8, 9, 11, - 12, - 13 + 13, + 15 ], "required_block_ids": [ "p1:0", @@ -27,54 +26,15 @@ "p1:10", "p1:11", "p1:12", - "p3:1", "p3:2", - "p4:1", "p4:2", - "p4:6", - "p5:7", "p5:10", - "p5:11", "p6:1", - "p6:2", - "p6:5", - "p7:3", "p7:4", - "p7:5", - "p7:6", - "p8:4", - "p8:6", - "p9:4", "p9:6", "p9:7", - "p9:8", - "p11:0", "p11:1", - "p11:2", - "p11:3", - "p11:4", - "p11:5", - "p11:6", - "p11:7", - "p11:8", - "p12:0", - "p12:1", - "p12:2", - "p12:3", - "p12:4", - "p12:5", - "p12:6", - "p12:7", - "p12:8", - "p12:9", - "p12:10", - "p12:11", - "p12:12", - "p12:13", - "p12:14", - "p12:15", "p13:4", - "p13:5", "p13:9", "p13:11", "p13:12", @@ -85,7 +45,80 @@ "p13:17", "p13:18", "p13:19", - "p13:20" + "p13:20", + "p15:1", + "p15:2", + "p15:3", + "p15:4", + "p15:5", + "p15:6", + "p15:7", + "p15:8", + "p15:9", + "p15:10", + "p15:11", + "p15:12", + "p15:13", + "p15:14", + "p15:15", + "p15:16", + "p15:17", + "p15:18", + "p15:19", + "p15:20", + "p15:21", + "p15:22", + "p15:23", + "p15:24", + "p15:25", + "p15:26", + "p15:27", + "p15:28", + "p15:29", + "p15:30", + "p15:31", + "p15:32", + "p15:33", + "p15:34", + "p15:35", + "p15:36", + "p15:37", + "p15:38", + "p15:39", + "p15:40", + "p15:41", + "p15:42", + "p15:43", + "p15:44", + "p15:45", + "p15:46", + "p15:47", + "p15:48", + "p15:49", + "p15:50", + "p15:51", + "p15:52", + "p15:53", + "p15:54", + "p15:55", + "p15:56", + "p15:57", + "p15:58", + "p15:59", + "p15:60", + "p15:61", + "p15:62", + "p15:63", + "p15:64", + "p15:65", + "p15:66", + "p15:67", + "p15:68", + "p15:69", + "p15:70", + "p15:71", + "p15:72", + "p15:73" ], "required_blocks": [ { @@ -284,21 +317,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p3:1", - "page": 3, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p3:2", "page": 3, @@ -314,21 +332,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p4:1", - "page": 4, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p4:2", "page": 4, @@ -344,36 +347,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p4:6", - "page": 4, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p5:7", - "page": 5, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p5:10", "page": 5, @@ -389,21 +362,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p5:11", - "page": 5, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p6:1", "page": 6, @@ -419,51 +377,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p6:2", - "page": 6, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p6:5", - "page": 6, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:3", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p7:4", "page": 7, @@ -479,81 +392,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p7:5", - "page": 7, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p7:6", - "page": 7, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:4", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p8:6", - "page": 8, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p9:4", - "page": 9, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p9:6", "page": 9, @@ -584,41 +422,10 @@ "truth_reference_membership" ] }, - { - "block_id": "p9:8", - "page": 9, - "required_reason": [ - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:0", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p11:1", "page": 11, "required_reason": [ - "backmatter", "object_ownership" ], "minimum_fields": [ @@ -630,355 +437,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p11:2", - "page": 11, - "required_reason": [ - "backmatter", - "object_ownership" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:3", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:4", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:5", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:6", - "page": 11, - "required_reason": [ - "backmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:7", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p11:8", - "page": 11, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:0", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:1", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:2", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:3", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:4", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:5", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:6", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:7", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:8", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:9", - "page": 12, - "required_reason": [ - "backmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:10", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:11", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:12", - "page": 12, - "required_reason": [ - "backmatter", - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:13", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:14", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, - { - "block_id": "p12:15", - "page": 12, - "required_reason": [ - "backmatter" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p13:4", "page": 13, @@ -994,21 +452,6 @@ "truth_reference_membership" ] }, - { - "block_id": "p13:5", - "page": 13, - "required_reason": [ - "needs_resolution" - ], - "minimum_fields": [ - "block_id", - "page", - "review_status", - "truth_role", - "truth_zone", - "truth_reference_membership" - ] - }, { "block_id": "p13:9", "page": 13, @@ -1174,6 +617,1103 @@ "truth_zone", "truth_reference_membership" ] + }, + { + "block_id": "p15:1", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:2", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:3", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:4", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:5", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:6", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:7", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:8", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:9", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:10", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:11", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:12", + "page": 15, + "required_reason": [ + "reference_span" + ], + "minimum_fields": [ + "block_id", + 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"minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:66", + "page": 15, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:67", + "page": 15, + "required_reason": [ + "backmatter", + "needs_resolution" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:68", + "page": 15, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:69", + "page": 15, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:70", + "page": 15, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:71", + "page": 15, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:72", + "page": 15, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] + }, + { + "block_id": "p15:73", + "page": 15, + "required_reason": [ + "backmatter" + ], + "minimum_fields": [ + "block_id", + "page", + "review_status", + "truth_role", + "truth_zone", + "truth_reference_membership" + ] } ], "selected_page_requirements": [ @@ -1185,52 +1725,47 @@ { "page": 3, "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 4, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 1 }, { "page": 5, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 1 }, { "page": 6, "must_review_page": true, - "required_block_count": 3 + "required_block_count": 1 }, { "page": 7, "must_review_page": true, - "required_block_count": 4 - }, - { - "page": 8, - "must_review_page": true, - "required_block_count": 2 + "required_block_count": 1 }, { "page": 9, "must_review_page": true, - "required_block_count": 4 + "required_block_count": 2 }, { "page": 11, "must_review_page": true, - "required_block_count": 9 - }, - { - "page": 12, - "must_review_page": true, - "required_block_count": 16 + "required_block_count": 1 }, { "page": 13, "must_review_page": true, - "required_block_count": 13 + "required_block_count": 12 + }, + { + "page": 15, + "must_review_page": true, + "required_block_count": 73 } ] } \ No newline at end of file diff --git a/audit/TSCKAVIS/block_coverage_summary.json b/audit/TSCKAVIS/block_coverage_summary.json index dcd57c34..3ba23370 100644 --- a/audit/TSCKAVIS/block_coverage_summary.json +++ b/audit/TSCKAVIS/block_coverage_summary.json @@ -440,7 +440,7 @@ "block_id": "p2:7", "page": 2, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -480,7 +480,7 @@ "block_id": "p2:9", "page": 2, "raw_label": "paragraph_title", - "role": "subsection_heading", + "role": "unknown_structural", "zone": "body_zone", "bbox": [ 607.0, @@ -640,7 +640,7 @@ "block_id": "p3:1", "page": 3, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 77.0, @@ -660,7 +660,7 @@ "block_id": "p3:2", "page": 3, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 74.0, @@ -740,7 +740,7 @@ "block_id": "p4:1", "page": 4, "raw_label": "figure_title", - "role": "table_caption_candidate", + "role": "table_caption", "zone": "display_zone", "bbox": [ 77.0, @@ -760,7 +760,7 @@ "block_id": "p4:2", "page": 4, "raw_label": "table", - "role": "media_asset", + "role": "table_html", "zone": "body_zone", "bbox": [ 77.0, @@ -840,7 +840,7 @@ "block_id": "p4:6", "page": 4, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -1060,7 +1060,7 @@ "block_id": "p5:7", "page": 5, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -1120,7 +1120,7 @@ "block_id": "p5:10", "page": 5, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 610.0, @@ -1140,7 +1140,7 @@ "block_id": "p5:11", "page": 5, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 606.0, @@ -1220,7 +1220,7 @@ "block_id": "p6:1", "page": 6, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 78.0, @@ -1240,7 +1240,7 @@ "block_id": "p6:2", "page": 6, "raw_label": "text", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 74.0, @@ -1300,7 +1300,7 @@ "block_id": "p6:5", "page": 6, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 606.0, @@ -1460,7 +1460,7 @@ "block_id": "p7:3", "page": 7, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -1480,7 +1480,7 @@ "block_id": "p7:4", "page": 7, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 82.0, @@ -1500,7 +1500,7 @@ "block_id": "p7:5", "page": 7, "raw_label": "text", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 74.0, @@ -1520,7 +1520,7 @@ "block_id": "p7:6", "page": 7, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 613.0, @@ -1660,7 +1660,7 @@ "block_id": "p8:4", "page": 8, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -1700,7 +1700,7 @@ "block_id": "p8:6", "page": 8, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -1880,7 +1880,7 @@ "block_id": "p9:4", "page": 9, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -1920,7 +1920,7 @@ "block_id": "p9:6", "page": 9, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 82.0, @@ -1940,7 +1940,7 @@ "block_id": "p9:7", "page": 9, "raw_label": "image", - "role": "media_asset", + "role": "figure_asset", "zone": "body_zone", "bbox": [ 462.0, @@ -1960,7 +1960,7 @@ "block_id": "p9:8", "page": 9, "raw_label": "figure_title", - "role": "figure_caption_candidate", + "role": "figure_caption", "zone": "display_zone", "bbox": [ 74.0, @@ -2120,7 +2120,7 @@ "block_id": "p10:4", "page": 10, "raw_label": "text", - "role": "unknown_structural", + "role": "body_paragraph", "zone": "body_zone", "bbox": [ 605.0, @@ -2241,7 +2241,7 @@ "page": 11, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 77.0, 80.0, @@ -2260,8 +2260,8 @@ "block_id": "p11:1", "page": 11, "raw_label": "image", - "role": "media_asset", - "zone": "tail_nonref_hold_zone", + "role": "figure_asset", + "zone": "body_zone", "bbox": [ 82.0, 228.0, @@ -2280,8 +2280,8 @@ "block_id": "p11:2", "page": 11, "raw_label": "figure_title", - "role": "figure_caption_candidate", - "zone": "tail_nonref_hold_zone", + "role": "figure_caption", + "zone": "display_zone", "bbox": [ 74.0, 868.0, @@ -2301,7 +2301,7 @@ "page": 11, "raw_label": "vision_footnote", "role": "footnote", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 607.0, 867.0, @@ -2321,7 +2321,7 @@ "page": 11, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 73.0, 1040.0, @@ -2341,7 +2341,7 @@ "page": 11, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 74.0, 1342.0, @@ -2360,8 +2360,8 @@ "block_id": "p11:6", "page": 11, "raw_label": "text", - "role": "unknown_structural", - "zone": "tail_nonref_hold_zone", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 605.0, 1040.0, @@ -2381,7 +2381,7 @@ "page": 11, "raw_label": "footer", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 75.0, 1523.0, @@ -2401,7 +2401,7 @@ "page": 11, "raw_label": "number", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 1088.0, 1524.0, @@ -2421,7 +2421,7 @@ "page": 12, "raw_label": "header", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 77.0, 81.0, @@ -2441,7 +2441,7 @@ "page": 12, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 74.0, 222.0, @@ -2461,7 +2461,7 @@ "page": 12, "raw_label": "paragraph_title", "role": "subsection_heading", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 74.0, 371.0, @@ -2481,7 +2481,7 @@ "page": 12, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 73.0, 397.0, @@ -2501,7 +2501,7 @@ "page": 12, "raw_label": "paragraph_title", "role": "section_heading", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 73.0, 502.0, @@ -2521,7 +2521,7 @@ "page": 12, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 73.0, 546.0, @@ -2541,7 +2541,7 @@ "page": 12, "raw_label": "paragraph_title", "role": "structured_insert", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 87.0, 891.0, @@ -2561,7 +2561,7 @@ "page": 12, "raw_label": "footer", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 87.0, 939.0, @@ -2581,7 +2581,7 @@ "page": 12, "raw_label": "text", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 84.0, 1039.0, @@ -2600,8 +2600,8 @@ "block_id": "p12:9", "page": 12, "raw_label": "text", - "role": "unknown_structural", - "zone": "tail_nonref_hold_zone", + "role": "noise", + "zone": "body_zone", "bbox": [ 605.0, 223.0, @@ -2621,7 +2621,7 @@ "page": 12, "raw_label": "text", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 605.0, 612.0, @@ -2641,7 +2641,7 @@ "page": 12, "raw_label": "text", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 605.0, 805.0, @@ -2660,8 +2660,8 @@ "block_id": "p12:12", "page": 12, "raw_label": "paragraph_title", - "role": "unknown_structural", - "zone": "tail_nonref_hold_zone", + "role": "subsection_heading", + "zone": "body_zone", "bbox": [ 607.0, 1124.0, @@ -2681,7 +2681,7 @@ "page": 12, "raw_label": "text", "role": "body_paragraph", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 606.0, 1170.0, @@ -2701,7 +2701,7 @@ "page": 12, "raw_label": "footer", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 75.0, 1523.0, @@ -2721,7 +2721,7 @@ "page": 12, "raw_label": "number", "role": "noise", - "zone": "tail_nonref_hold_zone", + "zone": "body_zone", "bbox": [ 1091.0, 1524.0, @@ -2840,8 +2840,8 @@ "block_id": "p13:5", "page": 13, "raw_label": "text", - "role": "unknown_structural", - "zone": "", + "role": "body_paragraph", + "zone": "body_zone", "bbox": [ 604.0, 223.0, @@ -5960,8 +5960,8 @@ "block_id": "p15:63", "page": 15, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "", + "role": "sub_subsection_heading", + "zone": "tail_nonref_hold_zone", "bbox": [ 610.0, 1102.0, @@ -6000,8 +6000,8 @@ "block_id": "p15:65", "page": 15, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "", + "role": "unknown_structural", + "zone": "tail_nonref_hold_zone", "bbox": [ 609.0, 1166.0, @@ -6020,7 +6020,7 @@ "block_id": "p15:66", "page": 15, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 609.0, @@ -6040,8 +6040,8 @@ "block_id": "p15:67", "page": 15, "raw_label": "paragraph_title", - "role": "backmatter_heading", - "zone": "", + "role": "unknown_structural", + "zone": "tail_nonref_hold_zone", "bbox": [ 610.0, 1214.0, @@ -6060,7 +6060,7 @@ "block_id": "p15:68", "page": 15, "raw_label": "text", - "role": "backmatter_body", + "role": "body_paragraph", "zone": "tail_nonref_hold_zone", "bbox": [ 613.0, diff --git a/audit/TSCKAVIS/block_review.jsonl b/audit/TSCKAVIS/block_review.jsonl index ef0a92ce..71a5123a 100644 --- a/audit/TSCKAVIS/block_review.jsonl +++ b/audit/TSCKAVIS/block_review.jsonl @@ -23,7 +23,7 @@ {"block_id": "p6:2", "page": 6, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Fig. 2 caption confirmed; pipeline figure_caption_candidate/display_zone is correct", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p6:5", "page": 6, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Right-column body text about maintaining redox and energy balance; pipeline unknown_structural is wrong", "_pipeline_verified": true, "_current_role": "body_paragraph"} {"block_id": "p7:3", "page": 7, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Right-column body text about Glut4 GLUT1 osteoblast differentiation; pipeline unknown_structural is wrong", "_pipeline_verified": true, "_current_role": "body_paragraph"} -{"block_id": "p7:4", "page": 7, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 metabolic profile diagram; zone should be display_zone not body_zone", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} +{"block_id": "p7:4", "page": 7, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 metabolic profile diagram; zone should be display_zone not body_zone", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"} {"block_id": "p7:5", "page": 7, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Fig. 3 caption confirmed; pipeline figure_caption_candidate/display_zone is correct", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true} {"block_id": "p7:6", "page": 7, "review_status": "reviewed", "truth_role": "footnote", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 abbreviation list (AMPK GLUT GSH HIF etc); pipeline unknown_structural is wrong - should be footnote", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone"} {"block_id": "p8:4", "page": 8, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_008.png", "method": "visual+bbox"}, "short_reason": "Right-column body text about Slc13a5 cortical thickness bone mineral; pipeline unknown_structural is wrong", "_pipeline_verified": true, "_current_role": "body_paragraph"} diff --git a/audit/TSCKAVIS/block_trace.csv b/audit/TSCKAVIS/block_trace.csv index 53c873f5..1e3c94df 100644 --- a/audit/TSCKAVIS/block_trace.csv +++ b/audit/TSCKAVIS/block_trace.csv @@ -3,7 +3,7 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,1,header,https://doi.org/10.1038/s41574-024-00969-x,"[778.0, 80.0, 1125.0, 105.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,2,header,Check for updates,"[958.0, 185.0, 1125.0, 211.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False 1,3,text,Review article,"[75.0, 185.0, 216.0, 212.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False -1,4,doc_title,Metabolic regulation of skeletal cell fate and function,"[76.0, 235.0, 969.0, 375.0]",paper_title,0.6,"[""page-1 frontmatter title guard: Metabolic regulation of skeletal cell fate and function""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,doc_title,Metabolic regulation of skeletal cell fate and function,"[76.0, 235.0, 969.0, 375.0]",paper_title,0.8,"[""page-1 zone title_zone: Metabolic regulation of skeletal cell fate and function""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True 1,5,paragraph_title,Steve Stegen Ⓤ & Geert Carmeliet Ⓤ ✉ Abstract,"[74.0, 443.0, 421.0, 505.0]",authors,0.6,"[""author byline on page 1, assigned as authors: Steve Stegen \u24ca & Geert Carmeliet \u24ca \u2709 Abstract""]",authors,0.6,frontmatter_main_zone,support_like,none,True,True 1,6,footer,,"[75.0, 480.0, 167.0, 505.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,empty,False,False 1,7,abstract,Bone development and bone remodelling during adult life are highly anabolic processes requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone-resorbing osteoclasts inte,"[73.0, 542.0, 858.0, 1254.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True @@ -19,9 +19,11 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 2,4,paragraph_title,Introduction,"[76.0, 780.0, 210.0, 803.0]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True 2,5,text,"The skeleton has been considered to be a metabolically active organ for decades $ ^{1-3} $. The formation of bone, and also its maintenance throughout life, rely on highly anabolic, nutrient-consuming","[73.0, 805.0, 593.0, 1192.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,6,text,"Technological developments have enabled scientists to thoroughly analyse cell metabolism in vitro and even in vivo. Most studies have been performed in the context of cancer biology, but more recently","[73.0, 1192.0, 593.0, 1386.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,7,text,,"[606.0, 222.0, 1126.0, 289.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,7,text,"information on the importance of skeletal cell metabolism for bone +and whole-body physiology. The most relevant in vivo studies for this +Review are listed in Table 1.","[606.0, 222.0, 1126.0, 289.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,8,text,"In this Review, we summarize the current understanding of fuel selection and intermediary metabolic pathways in bone cells during bone formation, and how metabolic dysfunction can contribute to skelet","[73.0, 1385.0, 594.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,9,paragraph_title,Cell types involved in skeletal development and homeostasis,"[607.0, 306.0, 1098.0, 352.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell types involved in skeletal development and homeostasis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,9,paragraph_title,Cell types involved in skeletal development and homeostasis,"[607.0, 306.0, 1098.0, 352.0]",unknown_structural,0.8,"[""page-1 zone title_zone: Cell types involved in skeletal development and homeostasis""]",paper_title,0.8,body_zone,heading_like,none,False,True 2,10,text,Skeletal development strongly depends on the differentiation and activity of phenotypically distinct cell types that are derived from different lineages. The mesenchymal lineage gives rise to bone-for,"[606.0, 353.0, 1126.0, 483.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,11,text,"The different mature mesenchymal cell types are not derived from a single stem cell but from a diverse set of skeletal stem and progenitor cells (SSPCs), which are found in distinct anatomical niches ","[606.0, 483.0, 1127.0, 675.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,12,text,Osteoblasts derive from all subtypes of SSPCs and typically produce a collagenous extracellular matrix that later on becomes mineralized. Most terminally differentiated osteoblasts become progressivel,"[606.0, 675.0, 1128.0, 1322.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -29,17 +31,19 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 2,14,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 2,15,number,400,"[1086.0, 1524.0, 1125.0, 1543.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,0,paragraph_title,Review article,"[77.0, 80.0, 308.0, 116.0]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False -3,1,figure_title,Table 1 | In vivo metabolic studies in different cell types using transgenic mouse models,"[77.0, 222.0, 815.0, 249.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 1 | In vivo metabolic studies in different cell types ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -3,2,table,"
GeneCre driverPhenotypeCell functionMetabolismRefs.
SSPCs
Glut1Prrx1No effec","[74.0, 248.0, 1124.0, 1498.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,1,figure_title,Table 1 | In vivo metabolic studies in different cell types using transgenic mouse models,"[77.0, 222.0, 815.0, 249.0]",table_caption,0.9,"[""table prefix matched: Table 1 | In vivo metabolic studies in different cell types ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,2,table,"
GeneCre driverPhenotypeCell functionMetabolismRefs.
SSPCs
Glut1Prrx1No effec","[74.0, 248.0, 1124.0, 1498.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 3,3,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 557.0, 1544.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 3,4,number,401,"[1091.0, 1524.0, 1124.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 4,0,paragraph_title,Review article,"[77.0, 81.0, 308.0, 117.0]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False -4,1,figure_title,Table 1 (continued) | In vivo metabolic studies in different cell types using transgenic mouse models,"[77.0, 222.0, 917.0, 248.0]",table_caption_candidate,0.9,"[""table prefix matched: Table 1 (continued) | In vivo metabolic studies in different""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True -4,2,table,"
GeneCre driverPhenotypeCell functionMetabolismRefs.
Chondrocytes (continued)
Elovl6Sy","[77.0, 241.0, 1124.0, 903.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,1,figure_title,Table 1 (continued) | In vivo metabolic studies in different cell types using transgenic mouse models,"[77.0, 222.0, 917.0, 248.0]",table_caption,0.9,"[""table prefix matched: Table 1 (continued) | In vivo metabolic studies in different""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,2,table,"
GeneCre driverPhenotypeCell functionMetabolismRefs.
Chondrocytes (continued)
Elovl6Sy","[77.0, 241.0, 1124.0, 903.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 4,3,vision_footnote,"This table summarizes the most important in vivo studies mentioned in the main text.?, mechanism is not yet fully understood; αKG, α-ketoglutarate; Ac-CoA, acetyl coenzyme A; AMPK, AMP-activated prote","[73.0, 905.0, 1083.0, 975.0]",footnote,0.7,"[""vision_footnote label: This table summarizes the most important in vivo studies men""]",footnote,0.7,body_zone,body_like,none,True,True 4,4,paragraph_title,A general overview of cell metabolism,"[75.0, 1017.0, 469.0, 1041.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: A general overview of cell metabolism""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 4,5,text,"Historically, most studies in the bone field focused on identifying the nutritional sources and metabolic pathways that support the synthesis of ATP. The main cellular bioenergetic hub consists of the","[73.0, 1041.0, 595.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,6,text,,"[606.0, 1019.0, 1127.0, 1214.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,6,text,"securing energy homeostasis in oxygen-limiting conditions. In addi- +tion, lactate production also secures the regeneration of NADH from +NAD+, which is necessary for several biosynthetic reactions21. R","[606.0, 1019.0, 1127.0, 1214.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,7,text,"In addition to ATP production, many other metabolic pathways produce intermediates with additional regulatory roles (Fig. 2). For example, metabolites such as citrate, α-ketoglutarate and pyruvate can","[605.0, 1212.0, 1128.0, 1496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,8,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 4,9,number,402,"[1088.0, 1524.0, 1126.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -50,19 +54,23 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 5,4,text,"Of the different nutrients, glucose has long been considered to be the most important for SSPC function (Fig. 3), as evidenced by in vitro deprivation studies. Intriguingly, deletion of the glucose tr","[73.0, 675.0, 594.0, 1192.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,5,text,"Besides glucose, fatty acids are also a possible nutritional source for SSPCs, as these cells express several fatty acid oxidation (FAO)-related genes $ ^{30} $ (Fig. 3). However, carnitine palmitoylt","[73.0, 1192.0, 593.0, 1343.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,6,text,"Concerning amino acid metabolism, the amino acid sensor GCN2 (also known as eIF2AK4) controls the proliferation of bone marrow SSPCs and their progeny. GCN2 becomes activated when intracellular free a","[73.0, 1342.0, 594.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -5,7,text,,"[605.0, 223.0, 1125.0, 352.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +5,7,text,"amino acid in circulation32, is taken up by SSPCs, and its conversion to +α-ketoglutarate is important for the proliferation of cultured SSPCs33,34. +However, the in vivo deletion of the rate-limiting e","[605.0, 223.0, 1125.0, 352.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,8,text,The lack of an in vivo bone phenotype when important metabolic transporters or enzymes are deleted suggests that SSPCs display a high metabolic plasticity. This metabolic flexibility is probably neede,"[605.0, 353.0, 1128.0, 568.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,9,text,"In addition, the high metabolic plasticity of SSPCs provides strategic opportunities for tissue engineering approaches, whereby cells have to be transplanted in the avascular environment of the fractu","[605.0, 568.0, 1127.0, 765.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -5,10,image,,"[610.0, 799.0, 1126.0, 1337.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -5,11,figure_title,"Fig. 1 | Differentiation of bone-resident cell types. The mesenchymal lineage gives rise to skeletal stem and progenitor cells (SSPC) that can differentiate into cartilage-forming chondrocytes, bone-f","[606.0, 1353.0, 1122.0, 1494.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 1 | Differentiation of bone-resident cell types. The me""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +5,10,image,,"[610.0, 799.0, 1126.0, 1337.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +5,11,figure_title,"Fig. 1 | Differentiation of bone-resident cell types. The mesenchymal lineage gives rise to skeletal stem and progenitor cells (SSPC) that can differentiate into cartilage-forming chondrocytes, bone-f","[606.0, 1353.0, 1122.0, 1494.0]",figure_caption,0.92,"[""figure_title label: Fig. 1 | Differentiation of bone-resident cell types. The me""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 5,12,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 5,13,number,403,"[1088.0, 1524.0, 1124.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,0,paragraph_title,Review article,"[77.0, 80.0, 308.0, 117.0]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False -6,1,image,,"[78.0, 223.0, 1121.0, 1037.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -6,2,text,"Fig. 2 | Metabolic features of skeletal cells. Environmental cues lead to intracellular signalling, which in turn causes metabolic reprogramming. The metabolic pathways important for this Review inclu","[74.0, 1051.0, 583.0, 1214.0]",figure_caption_candidate,0.9,"[""figure prefix matched: Fig. 2 | Metabolic features of skeletal cells. Environmental"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,False,False +6,1,image,,"[78.0, 223.0, 1121.0, 1037.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +6,2,text,"Fig. 2 | Metabolic features of skeletal cells. Environmental cues lead to intracellular signalling, which in turn causes metabolic reprogramming. The metabolic pathways important for this Review inclu","[74.0, 1051.0, 583.0, 1214.0]",figure_caption,0.9,"[""figure prefix matched: Fig. 2 | Metabolic features of skeletal cells. Environmental"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True 6,3,vision_footnote,"histone and DNA modification to control skeletal cell fate and differentiation. Ac-CoA, acetyl coenzyme A; AMPK, AMP-activated protein kinase; CI–CIV, different complexes (C) of the ETC; CoQ, coenzyme","[607.0, 1050.0, 1119.0, 1194.0]",footnote,0.7,"[""vision_footnote label: histone and DNA modification to control skeletal cell fate a""]",footnote,0.7,body_zone,body_like,none,True,True 6,4,text,"maintain redox and energy balance and sustain proliferation $ ^{25} $. These metabolic changes also increase 2-hydroxyglutarate and succinate levels, which reduce ten-eleven translocation (TET) DNA de","[73.0, 1277.0, 593.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -6,5,text,,"[606.0, 1277.0, 1126.0, 1364.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +6,5,text,"cells use glycogenolysis to sustain their bioenergetic balance for longer +and they have increased ROS scavenging capacity. Conversely, deletion +of HIF1α in periosteal SSPCs reduces their survival and ","[606.0, 1277.0, 1126.0, 1364.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,6,text,"In summary, SSPCs display a high degree of metabolic plasticity, which enables them to function in changing microenvironments.","[606.0, 1364.0, 1125.0, 1408.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,7,text,"Osteoblasts use different nutrients to fulfil specific functions. Upon exposure to systemic or local osteogenic stimuli, SSPCs can differentiate into the osteogenic lineage. Osteoblasts are highly ana","[606.0, 1427.0, 1127.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,8,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -70,19 +78,27 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 7,0,paragraph_title,Review article,"[77.0, 80.0, 307.0, 115.0]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False 7,1,text,"cells that produce large amounts of matrix, but unlike other secretory skeletal cell types such as chondrocytes, they often localize close to blood vessels $ ^{40} $.","[74.0, 223.0, 593.0, 288.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,2,text,"Metabolically, osteoblast differentiation relies on GLUT1-mediated glucose uptake and Glut1 inactivation in cells expressing Sp7 (also known as osterix) reduces bone mass (Fig. 3). In osteoblasts, glu","[73.0, 289.0, 594.0, 420.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -7,3,text,,"[605.0, 223.0, 1128.0, 419.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True -7,4,image,,"[82.0, 454.0, 1123.0, 1377.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -7,5,text,"Fig. 3 | Metabolic profile of skeletal stem and progenitor cells, and their osteogenic and adipogenic descendants. Scheme of the metabolic profile, its regulation and importance for the function of sk","[74.0, 1392.0, 570.0, 1494.0]",figure_caption_candidate,0.9,"[""figure prefix matched: Fig. 3 | Metabolic profile of skeletal stem and progenitor c"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,False,False -7,6,text,,"[613.0, 1392.0, 1132.0, 1475.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +7,3,text,"(encoded by Glut4, also known as Slc2a4), on the other hand, mediates +insulin-stimulated glucose uptake, and its expression increases dur- +ing osteoblast differentiation. Glut4 deletion in mature oste","[605.0, 223.0, 1128.0, 419.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,image,,"[82.0, 454.0, 1123.0, 1377.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,5,text,"Fig. 3 | Metabolic profile of skeletal stem and progenitor cells, and their osteogenic and adipogenic descendants. Scheme of the metabolic profile, its regulation and importance for the function of sk","[74.0, 1392.0, 570.0, 1494.0]",figure_caption,0.9,"[""figure prefix matched: Fig. 3 | Metabolic profile of skeletal stem and progenitor c"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +7,6,text,"AMP-activated protein kinase; GLUT, glucose transporter; GSH, glutathione; HIF, +hypoxia-inducible transcription factor; MAS, malate-aspartate shuttle; NEAA, +non-essential amino acid; OXPHOS, oxidative","[613.0, 1392.0, 1132.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,7,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 7,8,number,405,"[1088.0, 1524.0, 1124.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,0,header,Review article,"[77.0, 80.0, 308.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,1,text,"or by being converted to malate by malic enzyme 2, especially during osteoblast differentiation $ ^{43} $. Malate is then considered to contribute to the malate–aspartate shuttle (MAS) that in osteobl","[73.0, 222.0, 594.0, 375.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,2,text,"Whether OXPHOS increases or decreases during osteoblast differentiation is still a matter of debate $ ^{43,45} $, and the contradictory observations might be explained by transient stage-specific fluc","[73.0, 374.0, 594.0, 849.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,3,text,"The availability of amino acids such as glutamine and proline is important for osteoblast functioning, primarily by supporting biosynthesis and redox homeostasis (Fig. 3). Proliferating osteoprogenito","[73.0, 848.0, 594.0, 1386.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,4,text,,"[605.0, 222.0, 1125.0, 311.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,4,text,"Slc13a5 in mature osteoblasts reduces cortical thickness and affects +matrix mineralization, without a clear effect on trabecular bone. Mech- +anistically, more glucose-derived citrate was detected in t","[605.0, 222.0, 1125.0, 311.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,5,text,"Metabolites not only regulate intracellular properties but can also function extracellularly. Citrate is such a metabolite as it is part of the TCA cycle and contributes to lipogenesis, but is also hi","[73.0, 1385.0, 594.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,6,text,,"[605.0, 310.0, 1127.0, 721.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,6,text,"mineral, but it remains unknown how citrate affects mineral integrity59. +Several in vivo studies indicate that metabolic pathways are +enhanced by bone anabolic agents and by stimulation of HIF signal-","[605.0, 310.0, 1127.0, 721.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,7,text,"Bone marrow adipocytes are a unique cell type. During ageing and in response to environmental or nutritional stimuli, marrow SSPCs or osteoadipogenic progenitors differentiate into BMAds, which progre","[606.0, 739.0, 1127.0, 1128.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,8,text,"Metabolically, the gene expression profile of adipogenic progenitors differs from that of osteogenic progenitors and is characterized by increased OXPHOS, but these in vitro data still need in vivo co","[605.0, 1127.0, 1128.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,9,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1522.0, 557.0, 1544.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -91,11 +107,13 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 9,1,text,"of Adipo-CAR cells and BMAds, and their metabolic interaction with surrounding skeletal and haematopoietic cells, is likely to contribute to our understanding of the bone phenotype in obesity, diabete","[73.0, 223.0, 594.0, 291.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,2,paragraph_title,Growth plate chondrocytes are adapted to a specific metabolic microenvironment,"[73.0, 306.0, 526.0, 352.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: Growth plate chondrocytes are adapted to a specific metaboli""]",section_heading,0.6,body_zone,heading_like,none,True,True 9,3,text,"During long-bone development, SSPCs not only differentiate into osteoblasts and BMAds, but also give rise to chondrocytes in the early phases of the developmental process $ ^{16} $. Chondrocytes are u","[73.0, 353.0, 595.0, 744.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -9,4,text,,"[605.0, 223.0, 1127.0, 589.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +9,4,text,"an energy deficit owing to reduced glucose oxidation, indicating that a +certain degree of mitochondrial respiration is still necessary in, prob- +ably, the peripherally located chondrocytes89. In line ","[605.0, 223.0, 1127.0, 589.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,5,text,"Glucose, taken up mainly by GLUT1, a process regulated by BMP-HIF1α $ ^{27} $, appears to be an essential nutrient for chondrocytes (Fig. 4b), as conditional Glut1 deletion decreases their proliferati","[605.0, 589.0, 1127.0, 743.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -9,6,image,,"[82.0, 782.0, 442.0, 1213.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -9,7,image,,"[462.0, 778.0, 1119.0, 1401.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -9,8,figure_title,"Fig. 4 | Metabolic regulation of chondrocyte function. a, Low lipid availability and low oxygen levels increase SOX9 expression, which stimulates the differentiation of skeletal stem and progenitor ce","[74.0, 1412.0, 582.0, 1494.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 4 | Metabolic regulation of chondrocyte function. a, Lo""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +9,6,image,,"[82.0, 782.0, 442.0, 1213.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +9,7,image,,"[462.0, 778.0, 1119.0, 1401.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +9,8,figure_title,"Fig. 4 | Metabolic regulation of chondrocyte function. a, Low lipid availability and low oxygen levels increase SOX9 expression, which stimulates the differentiation of skeletal stem and progenitor ce","[74.0, 1412.0, 582.0, 1494.0]",figure_caption,0.92,"[""figure_title label: Fig. 4 | Metabolic regulation of chondrocyte function. a, Lo""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 9,9,vision_footnote,"chondrocyte function. Acan, aggrecan; Ac-CoA, acetyl coenzyme A; GLS1, glutaminase 1; GSH, glutathione; HIF, hypoxia-inducible transcription factor; PHGDH, phosphoglycerate dehydrogenase; ROS, reactiv","[606.0, 1412.0, 1114.0, 1493.0]",footnote,0.7,"[""vision_footnote label: chondrocyte function. Acan, aggrecan; Ac-CoA, acetyl coenzym""]",footnote,0.7,body_zone,body_like,none,True,True 9,10,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 557.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 9,11,number,407,"[1088.0, 1524.0, 1125.0, 1543.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -103,43 +121,52 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 10,1,text,"are equally important for chondrocyte function (for example, by supporting biosynthetic processes). Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in the serine synthesis pathway (SS","[73.0, 223.0, 594.0, 719.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,2,text,"The observation that TCA cycle anaplerosis by glucose is rather limited in chondrocytes suggests that these cells rely on other nutritional sources. Fatty acids are not a likely candidate, as these re","[73.0, 719.0, 594.0, 1149.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,3,text,"Although exogenous fatty acids seem to have minimal importance for chondrocyte function, glutamine has been shown to complement glucose in supporting chondrocyte anabolism as part of a feedforward pro","[73.0, 1150.0, 593.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,4,text,,"[605.0, 223.0, 1126.0, 355.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,4,text,"healing34. Yet, excessive glutamine flux must be avoided, as increased +glutamine-dependent α-ketoglutarate production, caused by consti- +tutively active HIF1α signalling, stimulates collagen hydroxyla","[605.0, 223.0, 1126.0, 355.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,5,paragraph_title,Metabolic adaptations during osteoclast differentiation,"[606.0, 371.0, 1026.0, 416.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic adaptations during osteoclast differentiation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 10,6,text,Bone homeostasis and quality depend on a well-adjusted balance between osteoblasts and osteoclasts. Osteoclast differentiation critically depends on the production of RANKL (encoded by Tnfsf11) by ost,"[605.0, 418.0, 1128.0, 1406.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,7,text,"Besides fatty acids, glucose is another major nutrient for osteoclasts. GLUT1-mediated glucose uptake increases during osteoclast differentiation and is associated not only with enhanced OXPHOS but al","[604.0, 1407.0, 1128.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,8,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 557.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 10,9,number,408,"[1088.0, 1524.0, 1125.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -11,0,header,Review article,"[77.0, 80.0, 308.0, 115.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -11,1,image,,"[82.0, 228.0, 1111.0, 848.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -11,2,figure_title,"Fig. 5 | Metabolic regulation of osteoclast differentiation and activity. a, M-CSF and RANKL induce the differentiation of osteoclast progenitors to mature active osteoclasts by regulating the metabol","[74.0, 868.0, 541.0, 970.0]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 5 | Metabolic regulation of osteoclast differentiation ""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False -11,3,vision_footnote,"palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fatty acid oxidation; GLUT1, glucose transporter 1; M-CSF, macrophage colony-stimulating factor; Me, methyl; OXPHOS, oxidative phosphorylation","[607.0, 867.0, 1123.0, 971.0]",footnote,0.7,"[""vision_footnote label: palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fa""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True -11,4,text,"for ATP synthesis $ ^{110,111} $. Glut1 deletion impairs glycolysis more than it impairs OXPHOS, and it also decreases in vitro osteoclastogenesis (Fig. 5b). Interestingly, Glut1 deletion in Lyz2-expr","[73.0, 1040.0, 593.0, 1342.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -11,5,text,"Amino acid metabolism also contributes to osteoclastogenesis, although, for some amino acids, the exact metabolic mechanism is not fully understood. Preosteoclasts take up glutamine via SLC1A5, which ","[74.0, 1342.0, 594.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -11,6,text,,"[605.0, 1040.0, 1128.0, 1494.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True -11,7,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -11,8,number,409,"[1088.0, 1524.0, 1124.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -12,0,header,Review article,"[77.0, 81.0, 307.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -12,1,text,line with the observation that Tie2-Cre-mediated deletion of Arg1 does not affect osteoclast properties at baseline $ ^{117} $. Whether Arg1-conditional knockout mice are more susceptible to inflammat,"[74.0, 222.0, 593.0, 356.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,2,paragraph_title,Metabolic disturbance during bone pathology,"[74.0, 371.0, 548.0, 397.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic disturbance during bone pathology""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True -12,3,text,"Most studies investigating skeletal cell metabolism have been performed during bone development, but more recent evidence suggests that alterations in specific metabolic pathways underly skeletal path","[73.0, 397.0, 593.0, 484.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,4,paragraph_title,Metabolic dysfunction in osteoarthritic chondrocytes is associated with disease progression,"[73.0, 502.0, 542.0, 547.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: Metabolic dysfunction in osteoarthritic chondrocytes is asso""]",section_heading,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -12,5,text,"Osteoarthritis is a complex, multifactorial disease that is characterized by the progressive deterioration of the articular cartilage and structural changes to the entire joint, leading to severe disa","[73.0, 546.0, 594.0, 851.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,6,paragraph_title,Box 1 Osteoarthritis: a largely unmet clinical problem,"[87.0, 891.0, 554.0, 1021.0]",structured_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Box 1 Osteoarthritis: a largely unmet clinical problem""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,False,False -12,7,footer,,"[87.0, 939.0, 554.0, 1021.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,empty,False,False -12,8,text,"Osteoarthritis is the most common degenerative joint disease, and occurs with increasing prevalence due to our ageing population. It represents a major public health burden, as current therapies are l","[84.0, 1039.0, 572.0, 1475.0]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False -12,9,text,,"[605.0, 223.0, 1127.0, 612.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True -12,10,text,"Osteoarthritic chondrocytes also display changes in lipid metabolism, as evidenced by increased cholesterol uptake, increased expression of cholesterol hydroxylases (CH25H and CYP7B1) and enhanced pro","[605.0, 612.0, 1127.0, 805.0]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False -12,11,text,"Finally, amino acid-metabolizing pathways also appear to be altered in osteoarthritic chondrocytes $ ^{32} $, although in vivo data are still limited. ARG2, which converts the conditionally essential ","[605.0, 805.0, 1128.0, 1107.0]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False -12,12,paragraph_title,Metabolic alterations in osteolineage cells during diabetic bone loss,"[607.0, 1124.0, 1116.0, 1169.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic alterations in osteolineage cells during diabetic ""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,False,True -12,13,text,"There is increasing evidence that diabetes is associated with increased bone fracture risk, although the underlying cellular and molecular mechanisms are not well understood and are probably multiface","[606.0, 1170.0, 1128.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -12,14,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -12,15,number,410,"[1091.0, 1524.0, 1126.0, 1543.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +11,0,header,Review article,"[77.0, 80.0, 308.0, 115.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,1,image,,"[82.0, 228.0, 1111.0, 848.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +11,2,figure_title,"Fig. 5 | Metabolic regulation of osteoclast differentiation and activity. a, M-CSF and RANKL induce the differentiation of osteoclast progenitors to mature active osteoclasts by regulating the metabol","[74.0, 868.0, 541.0, 970.0]",figure_caption,0.92,"[""figure_title label: Fig. 5 | Metabolic regulation of osteoclast differentiation ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,3,vision_footnote,"palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fatty acid oxidation; GLUT1, glucose transporter 1; M-CSF, macrophage colony-stimulating factor; Me, methyl; OXPHOS, oxidative phosphorylation","[607.0, 867.0, 1123.0, 971.0]",footnote,0.7,"[""vision_footnote label: palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fa""]",footnote,0.7,body_zone,body_like,none,True,True +11,4,text,"for ATP synthesis $ ^{110,111} $. Glut1 deletion impairs glycolysis more than it impairs OXPHOS, and it also decreases in vitro osteoclastogenesis (Fig. 5b). Interestingly, Glut1 deletion in Lyz2-expr","[73.0, 1040.0, 593.0, 1342.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"Amino acid metabolism also contributes to osteoclastogenesis, although, for some amino acids, the exact metabolic mechanism is not fully understood. Preosteoclasts take up glutamine via SLC1A5, which ","[74.0, 1342.0, 594.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,"outcome differs depending on whether the transporter or metabolic +enzyme is inactivated114–116. The SLC7A5 transporter mediates uptake +of large neutral amino acids, including the essential amino acids","[605.0, 1040.0, 1128.0, 1494.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,8,number,409,"[1088.0, 1524.0, 1124.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,header,Review article,"[77.0, 81.0, 307.0, 117.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,1,text,line with the observation that Tie2-Cre-mediated deletion of Arg1 does not affect osteoclast properties at baseline $ ^{117} $. Whether Arg1-conditional knockout mice are more susceptible to inflammat,"[74.0, 222.0, 593.0, 356.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,2,paragraph_title,Metabolic disturbance during bone pathology,"[74.0, 371.0, 548.0, 397.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic disturbance during bone pathology""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +12,3,text,"Most studies investigating skeletal cell metabolism have been performed during bone development, but more recent evidence suggests that alterations in specific metabolic pathways underly skeletal path","[73.0, 397.0, 593.0, 484.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,paragraph_title,Metabolic dysfunction in osteoarthritic chondrocytes is associated with disease progression,"[73.0, 502.0, 542.0, 547.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: Metabolic dysfunction in osteoarthritic chondrocytes is asso""]",section_heading,0.6,body_zone,body_like,none,True,True +12,5,text,"Osteoarthritis is a complex, multifactorial disease that is characterized by the progressive deterioration of the articular cartilage and structural changes to the entire joint, leading to severe disa","[73.0, 546.0, 594.0, 851.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,paragraph_title,Box 1 Osteoarthritis: a largely unmet clinical problem,"[87.0, 891.0, 554.0, 1021.0]",structured_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Box 1 Osteoarthritis: a largely unmet clinical problem""]",subsection_heading,0.6,body_zone,heading_like,none,False,False +12,7,footer,,"[87.0, 939.0, 554.0, 1021.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +12,8,text,"Osteoarthritis is the most common degenerative joint disease, and occurs with increasing prevalence due to our ageing population. It represents a major public health burden, as current therapies are l","[84.0, 1039.0, 572.0, 1475.0]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,9,text,"In addition to the mitochondrial defects, glycolysis is enhanced in +osteoarthritic chondrocytes, probably reflecting their hypoxic micro- +environment, but perhaps also as a metabolic compensation for ","[605.0, 223.0, 1127.0, 612.0]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,10,text,"Osteoarthritic chondrocytes also display changes in lipid metabolism, as evidenced by increased cholesterol uptake, increased expression of cholesterol hydroxylases (CH25H and CYP7B1) and enhanced pro","[605.0, 612.0, 1127.0, 805.0]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,11,text,"Finally, amino acid-metabolizing pathways also appear to be altered in osteoarthritic chondrocytes $ ^{32} $, although in vivo data are still limited. ARG2, which converts the conditionally essential ","[605.0, 805.0, 1128.0, 1107.0]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,12,paragraph_title,Metabolic alterations in osteolineage cells during diabetic bone loss,"[607.0, 1124.0, 1116.0, 1169.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic alterations in osteolineage cells during diabetic ""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +12,13,text,"There is increasing evidence that diabetes is associated with increased bone fracture risk, although the underlying cellular and molecular mechanisms are not well understood and are probably multiface","[606.0, 1170.0, 1128.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,14,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75.0, 1523.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,15,number,410,"[1091.0, 1524.0, 1126.0, 1543.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 13,0,header,Review article,"[77.0, 80.0, 308.0, 115.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False 13,1,text,"that bone marrow SSPCs from these diabetic mice display a reduction in glycolysis, which is associated with decreased expression of osteogenic genes $ ^{129} $. Glut1 deletion in Sp7-expressing osteol","[73.0, 223.0, 594.0, 570.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,2,paragraph_title,Are malignant cells in the bone environment metabolically adapted?,"[73.0, 587.0, 529.0, 631.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Are malignant cells in the bone environment metabolically ad""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 13,3,text,"Metastatic cancer cells are considered to have a specific metabolic profile that is adapted to the local microenvironment of the tissue they home to $ ^{[131,132]} $, but whether tumour cells that for","[73.0, 634.0, 594.0, 1063.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,4,text,"The bone microenvironment also contributes to the progression of haematological malignancies by influencing their metabolic profile, often by unidirectional or bidirectional metabolite exchange $ ^{13","[73.0, 1064.0, 594.0, 1495.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -13,5,text,,"[604.0, 223.0, 1127.0, 399.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True +13,5,text,"Chronic lymphocytic leukaemia (CLL) cells also metabolically +interact with bone cells to produce GSH. In general, GSH synthesis +depends on the uptake of cystine, which is then converted to cysteine, +t","[604.0, 223.0, 1127.0, 399.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,6,paragraph_title,Conclusions,"[608.0, 415.0, 744.0, 438.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusions""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True 13,7,text,"Over the past decade, substantial progress has been made in unravelling skeletal cell metabolism and its contribution to cell-specific behaviour. These findings highlight that nutrient availability ch","[605.0, 438.0, 1127.0, 697.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,8,text,"However, several questions remain to be answered. For example, are metabolic interactions between different skeletal cell types important? Is the metabolism of skeletal cells altered during bone patho","[605.0, 697.0, 1128.0, 1088.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -295,16 +322,16 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 15,60,reference_content,"142. van Gastel, N. et al. Induction of a timed metabolic collapse to overcome cancer chemoresistance. Cell Metab. 32, 391–403.e6 (2020).","[611.0, 993.0, 1078.0, 1022.0]",reference_item,0.85,"[""reference content label: 142. van Gastel, N. et al. Induction of a timed metabolic co""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 15,61,reference_content,"143. Zhang, W. et al. Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat. Cell Biol. 14, 276–286 (2012).","[611.0, 1025.0, 1114.0, 1055.0]",reference_item,0.85,"[""reference content label: 143. Zhang, W. et al. Stromal control of cystine metabolism ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 15,62,reference_content,"144. Panaroni, C. et al. Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins. Blood 139, 876–888 (2022).","[610.0, 1057.0, 1118.0, 1087.0]",reference_item,0.85,"[""reference content label: 144. Panaroni, C. et al. Multiple myeloma cells induce lipol""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True -15,63,paragraph_title,Acknowledgements,"[610.0, 1102.0, 767.0, 1119.0]",backmatter_heading,0.8,"[""backmatter heading on page 15: Acknowledgements""]",backmatter_heading_candidate,0.8,,unknown_like,short_fragment,True,True +15,63,paragraph_title,Acknowledgements,"[610.0, 1102.0, 767.0, 1119.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True 15,64,text,"The authors thank Fonds voor Wetenschappelijk Onderzoek-Flanders for funding: EOS-GOF8218N, GOB3418N, GOC5120, G071321N, Hercules-I013518N.","[609.0, 1120.0, 1054.0, 1152.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -15,65,paragraph_title,Author contributions,"[609.0, 1166.0, 773.0, 1183.0]",backmatter_heading,0.8,"[""backmatter heading on page 15: Author contributions""]",backmatter_heading_candidate,0.8,,support_like,none,True,True -15,66,text,The authors contributed equally to all aspects of the article.,"[609.0, 1184.0, 937.0, 1200.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -15,67,paragraph_title,Competing interests,"[610.0, 1214.0, 770.0, 1231.0]",backmatter_heading,0.8,"[""backmatter heading on page 15: Competing interests""]",backmatter_heading_candidate,0.8,,unknown_like,short_fragment,True,True -15,68,text,The authors declare no competing interests.,"[613.0, 1235.0, 854.0, 1248.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -15,69,paragraph_title,Additional information,"[609.0, 1261.0, 785.0, 1279.0]",backmatter_heading,0.8,"[""backmatter heading on page 15: Additional information""]",backmatter_heading_candidate,0.8,,unknown_like,none,True,True -15,70,text,"Peer review information Nature Reviews Endocrinology thanks Martina Rauner, Ryan Riddle and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.","[608.0, 1280.0, 1109.0, 1313.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,65,paragraph_title,Author contributions,"[609.0, 1166.0, 773.0, 1183.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True +15,66,text,The authors contributed equally to all aspects of the article.,"[609.0, 1184.0, 937.0, 1200.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,67,paragraph_title,Competing interests,"[610.0, 1214.0, 770.0, 1231.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing interests""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,False,True +15,68,text,The authors declare no competing interests.,"[613.0, 1235.0, 854.0, 1248.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,69,paragraph_title,Additional information,"[609.0, 1261.0, 785.0, 1279.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Additional information""]",backmatter_boundary_candidate,0.5,,unknown_like,none,True,True +15,70,text,"Peer review information Nature Reviews Endocrinology thanks Martina Rauner, Ryan Riddle and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.","[608.0, 1280.0, 1109.0, 1313.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 15,71,text,Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[608.0, 1328.0, 1084.0, 1361.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True -15,72,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[607.0, 1376.0, 1104.0, 1441.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -15,73,text,© Springer Nature Limited 2024,"[608.0, 1455.0, 789.0, 1473.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,72,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[607.0, 1376.0, 1104.0, 1441.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,73,text,© Springer Nature Limited 2024,"[608.0, 1455.0, 789.0, 1473.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 15,74,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[76.0, 1524.0, 556.0, 1543.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False 15,75,number,413,"[1092.0, 1524.0, 1124.0, 1542.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/audit/TSCKAVIS/changed_blocks_after_fallback.json b/audit/TSCKAVIS/changed_blocks_after_fallback.json index 9ebde369..eca25c67 100644 --- a/audit/TSCKAVIS/changed_blocks_after_fallback.json +++ b/audit/TSCKAVIS/changed_blocks_after_fallback.json @@ -232,7 +232,7 @@ { "block_id": "p7:4", "truth_role": "figure_asset", - "pipe_role": "media_asset", + "pipe_role": "figure_asset", "pipe_zone": "body_zone", "pipe_text_len": 0, "role_match": true, diff --git a/audit/TSCKAVIS/coverage_check.json b/audit/TSCKAVIS/coverage_check.json index 8adc842d..7ee911ac 100644 --- a/audit/TSCKAVIS/coverage_check.json +++ b/audit/TSCKAVIS/coverage_check.json @@ -2,31 +2,7 @@ "paper_key": "TSCKAVIS", "mode": "high-risk", "required_block_ids": [ - "p11:0", "p11:1", - "p11:2", - "p11:3", - "p11:4", - "p11:5", - "p11:6", - "p11:7", - "p11:8", - "p12:0", - "p12:1", - "p12:10", - "p12:11", - "p12:12", - "p12:13", - "p12:14", - "p12:15", - "p12:2", - "p12:3", - "p12:4", - "p12:5", - "p12:6", - "p12:7", - "p12:8", - "p12:9", "p13:11", "p13:12", "p13:13", @@ -38,8 +14,80 @@ "p13:19", "p13:20", "p13:4", - "p13:5", "p13:9", + "p15:1", + "p15:10", + "p15:11", + "p15:12", + "p15:13", + "p15:14", + "p15:15", + "p15:16", + "p15:17", + "p15:18", + "p15:19", + "p15:2", + "p15:20", + "p15:21", + "p15:22", + "p15:23", + "p15:24", + "p15:25", + "p15:26", + "p15:27", + "p15:28", + "p15:29", + "p15:3", + "p15:30", + "p15:31", + "p15:32", + "p15:33", + "p15:34", + "p15:35", + "p15:36", + "p15:37", + "p15:38", + "p15:39", + "p15:4", + "p15:40", + "p15:41", + "p15:42", + "p15:43", + "p15:44", + "p15:45", + "p15:46", + "p15:47", + "p15:48", + "p15:49", + "p15:5", + "p15:50", + "p15:51", + "p15:52", + "p15:53", + "p15:54", + "p15:55", + "p15:56", + "p15:57", + "p15:58", + "p15:59", + "p15:6", + "p15:60", + "p15:61", + "p15:62", + "p15:63", + "p15:64", + "p15:65", + "p15:66", + "p15:67", + "p15:68", + "p15:69", + "p15:7", + "p15:70", + "p15:71", + "p15:72", + "p15:73", + "p15:8", + "p15:9", "p1:0", "p1:1", "p1:10", @@ -53,27 +101,13 @@ "p1:7", "p1:8", "p1:9", - "p3:1", "p3:2", - "p4:1", "p4:2", - "p4:6", "p5:10", - "p5:11", - "p5:7", "p6:1", - "p6:2", - "p6:5", - "p7:3", "p7:4", - "p7:5", - "p7:6", - "p8:4", - "p8:6", - "p9:4", "p9:6", - "p9:7", - "p9:8" + "p9:7" ], "reviewed_block_ids": [ "p11:0", @@ -149,9 +183,85 @@ "p9:7", "p9:8" ], - "missing_block_ids": [], - "missing_pages": [], + "missing_block_ids": [ + "p15:1", + "p15:10", + "p15:11", + "p15:12", + 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file diff --git a/audit/TSCKAVIS/figure_table_ownership_summary.json b/audit/TSCKAVIS/figure_table_ownership_summary.json index df4a625b..4e26acb1 100644 --- a/audit/TSCKAVIS/figure_table_ownership_summary.json +++ b/audit/TSCKAVIS/figure_table_ownership_summary.json @@ -56,10 +56,25 @@ "unresolved": [] }, "tables": { - "matched_count": 0, + "matched_count": 2, "ambiguous_count": 0, "unmatched_asset_count": 1, - "matched": [], + "matched": [ + { + "table_number": 1, + "caption_block_id": 1, + "asset_block_ids": [], + "page": 3, + "match_status": "matched" + }, + { + "table_number": 1, + "caption_block_id": 1, + "asset_block_ids": [], + "page": 4, + "match_status": "matched" + } + ], "ambiguous": [] } } \ No newline at end of file diff --git a/audit/TSCKAVIS/fulltext_block_mapping_summary.json b/audit/TSCKAVIS/fulltext_block_mapping_summary.json index c5183c23..34528b14 100644 --- a/audit/TSCKAVIS/fulltext_block_mapping_summary.json +++ b/audit/TSCKAVIS/fulltext_block_mapping_summary.json @@ -1,7 +1,7 @@ { - "mappable_block_count": 282, - "found_count": 222, - "missing_count": 60, + "mappable_block_count": 290, + "found_count": 215, + "missing_count": 75, "rows": [ { "block_id": "p1:0", @@ -81,7 +81,7 @@ "render_default": false, "snippet": "Conclusions", "found_in_fulltext": true, - "fulltext_offset": 56147 + "fulltext_offset": 56088 }, { "block_id": "p1:10", @@ -111,7 +111,7 @@ "render_default": false, "snippet": "399", "found_in_fulltext": true, - "fulltext_offset": 75601 + "fulltext_offset": 75922 }, { "block_id": "p2:0", @@ -130,8 +130,8 @@ "zone": "frontmatter_side_zone", "render_default": false, "snippet": "Key points", - "found_in_fulltext": true, - "fulltext_offset": 1980 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p2:2", @@ -151,7 +151,7 @@ "render_default": false, "snippet": "• Metabolic disturbance is linked to skeletal cell dysfunction during bone patho", "found_in_fulltext": true, - "fulltext_offset": 2750 + "fulltext_offset": 1980 }, { "block_id": "p2:4", @@ -161,7 +161,7 @@ "render_default": true, "snippet": "Introduction", "found_in_fulltext": true, - "fulltext_offset": 2948 + "fulltext_offset": 2178 }, { "block_id": "p2:5", @@ -171,7 +171,7 @@ "render_default": true, "snippet": "The skeleton has been considered to be a metabolically active organ for decades ", "found_in_fulltext": true, - "fulltext_offset": 2961 + "fulltext_offset": 2191 }, { "block_id": "p2:6", @@ -181,7 +181,17 @@ "render_default": true, "snippet": "Technological developments have enabled scientists to thoroughly analyse cell me", "found_in_fulltext": true, - "fulltext_offset": 4129 + "fulltext_offset": 3359 + }, + { + "block_id": "p2:7", + "page": 2, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "information on the importance of skeletal cell metabolism for bone and whole-bod", + "found_in_fulltext": true, + "fulltext_offset": 3957 }, { "block_id": "p2:8", @@ -191,17 +201,17 @@ "render_default": true, "snippet": "In this Review, we summarize the current understanding of fuel selection and int", "found_in_fulltext": true, - "fulltext_offset": 4894 + "fulltext_offset": 4291 }, { "block_id": "p2:9", "page": 2, - "role": "subsection_heading", + "role": "unknown_structural", "zone": "body_zone", - "render_default": true, + "render_default": false, "snippet": "Cell types involved in skeletal development and homeostasis", - "found_in_fulltext": true, - "fulltext_offset": 5231 + "found_in_fulltext": false, + "fulltext_offset": -1 }, { "block_id": "p2:10", @@ -211,7 +221,7 @@ "render_default": true, "snippet": "Skeletal development strongly depends on the differentiation and activity of phe", "found_in_fulltext": true, - "fulltext_offset": 5291 + "fulltext_offset": 4624 }, { "block_id": "p2:11", @@ -221,7 +231,7 @@ "render_default": true, "snippet": "The different mature mesenchymal cell types are not derived from a single stem c", "found_in_fulltext": true, - "fulltext_offset": 5711 + "fulltext_offset": 5044 }, { "block_id": "p2:12", @@ -231,7 +241,7 @@ "render_default": true, "snippet": "Osteoblasts derive from all subtypes of SSPCs and typically produce a collagenou", "found_in_fulltext": true, - "fulltext_offset": 6296 + "fulltext_offset": 5629 }, { "block_id": "p2:13", @@ -241,7 +251,7 @@ "render_default": true, "snippet": "The formation of bone tissue is balanced by the action of bone-resorbing osteocl", "found_in_fulltext": true, - "fulltext_offset": 8272 + "fulltext_offset": 7605 }, { "block_id": "p2:14", @@ -274,12 +284,12 @@ "fulltext_offset": -1 }, { - "block_id": "p3:2", + "block_id": "p3:1", "page": 3, - "role": "media_asset", - "zone": "body_zone", + "role": "table_caption", + "zone": "display_zone", "render_default": true, - "snippet": "0.68), LAA (≤83°), and CSA (≥35°). The area under the ROC curve was highest for the CSA (0.855 vs","[100.0, 1329.0, 590.0, 1450.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"CSA is the most valuable measure for discriminating be- +tween the RCT and control groups (Figs. 2 and 3). This was +also reflected in the calculated sensitivity and specificity, +which were revealed to be","[624.0, 948.0, 1117.0, 1209.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,Discussion,"[629.0, 1250.0, 745.0, 1276.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,10,text,"The influence of individual scapular morphology on the pathogenesis of RCTs remains controversial. Although some authors place great importance on anatomic variants, particularly those of the acromion","[625.0, 1305.0, 1116.0, 1450.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,4,"[74.0, 66.0, 89.0, 86.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,ARTICLE IN PRESS,"[413.0, 5.0, 679.0, 36.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +4,2,header,B.K. Moor et al.,"[948.0, 64.0, 1082.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,figure_title,Table I Linear and logistic regression analysis for each parameter,"[83.0, 121.0, 593.0, 144.0]",figure_caption_candidate,0.85,"[""figure_title label: Table I Linear and logistic regression analysis for each par""]",figure_caption,0.85,,reference_like,citation_line,False,False +4,4,table,"
GeneCre driverPhenotypeCell function
GeneCre driverPhenotypeCell function
TopographyPEMF amplitude (mT)PEMF directionPlot abbreviation
Tissue culture plastic (TCP)0N/ANP
CTRL (n = 51)RCT (n = 51)Unadjusted difference (95% confidence interval, P value)
AI0.66 (0.6-0.72)0.74 (0.71-0.79)
CTRL (n = 51)RCT (n = 51)Unadjusted di", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:5", + "page": 4, + "role": "footnote", + "zone": "body_zone", + "render_default": true, + "snippet": "CRTL, control group; RCT, rotator cuff tear group; AI, acromion index; LAA, late", + "found_in_fulltext": true, + "fulltext_offset": 10731 + }, + { + "block_id": "p4:10", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Since the introduction of the AI by Nyffeler in 2006, his concept was strengthen", + "found_in_fulltext": true, + "fulltext_offset": 11071 + }, + { + "block_id": "p4:11", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "acromion, their results were comparable to those of Nyff- eler et al. A high AI ", + "found_in_fulltext": true, + "fulltext_offset": 11648 + }, + { + "block_id": "p4:12", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Contrary to these findings, Hamid et al $ ^{7} $ found no association between a ", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p4:13", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The present study supports the findings of Nyffeler et al. A significant differe", + "found_in_fulltext": true, + "fulltext_offset": 12279 + }, + { + "block_id": "p4:14", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "In addition, our study confirmed the results of Banas et al. Although the LAA wa", + "found_in_fulltext": true, + "fulltext_offset": 12546 + }, + { + "block_id": "p4:15", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "Finally, we confirmed the recently reported association between large CSAs and d", + "found_in_fulltext": true, + "fulltext_offset": 12906 + }, + { + "block_id": "p4:16", + "page": 4, + "role": "body_paragraph", + "zone": "body_zone", + "render_default": true, + "snippet": "The CSA reflects not only lateral extension of the acromion but also glenoid inc", + "found_in_fulltext": true, + "fulltext_offset": 13170 + }, + { + "block_id": "p5:0", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "ARTICLE IN PRESS", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:1", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "Scapular anatomy and rotator cuff tears", + "found_in_fulltext": false, + "fulltext_offset": -1 + }, + { + "block_id": "p5:2", + "page": 5, + "role": "noise", + "zone": "body_zone", + "render_default": false, + "snippet": "5", + "found_in_fulltext": true, + "fulltext_offset": 637 + }, + { + "block_id": "p5:3", + "page": 5, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "In contrast to other authors, we could not demonstrate a significant correlation", + "found_in_fulltext": true, + "fulltext_offset": 13854 + }, + { + "block_id": "p5:4", + "page": 5, + "role": "body_paragraph", + "zone": "tail_nonref_hold_zone", + "render_default": true, + "snippet": "There are limitations. 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b/docs/superpowers/plans/2026-06-19-ocr-maintenance-ux-implementation.md @@ -0,0 +1,523 @@ +# OCR Maintenance UX Implementation Plan + +> **For agentic workers:** REQUIRED SUB-SKILL: Use superpowers:subagent-driven-development (recommended) or superpowers:executing-plans to implement this plan task-by-task. Steps use checkbox (`- [ ]`) syntax for tracking. + +**Goal:** Redesign the plugin Maintenance tab so ordinary users see actionability-first OCR guidance instead of raw maintenance table state. + +**Architecture:** Keep `paperforge/worker/ocr_maintenance.py` as the backend truth source. Add a small UI-side categorization layer for `No Action Needed`, `Rebuild Recommended`, `OCR Failed`, and `Result Limited`, then rework `_renderMaintenanceTab()` to show a summary card, actionable sections, and a collapsed full table. Preserve existing maintenance commands and detailed data via progressive disclosure. + +**Tech Stack:** TypeScript, Obsidian plugin DOM APIs, Vitest, esbuild, existing Python-backed OCR maintenance rows. + +--- + +## File Structure + +### Files to modify + +- `paperforge/plugin/src/settings.ts` + - Replace the current table-first Maintenance tab rendering with summary-first sections. + - Wire category mapping, helper copy, disclosure details, and advanced full-table fallback. +- `paperforge/plugin/styles.css` + - Add focused styles for the new summary card, category chips, action cards, limitation section, and advanced details. +- `paperforge/plugin/src/i18n.ts` + - Add user-facing copy keys for the new Maintenance tab language so the tab does not hardcode raw engineering terminology. +- `paperforge/plugin/main.js` + - Rebuild bundled plugin output after TypeScript changes. +- `PROJECT-MANAGEMENT.md` + - Record the implemented UX redesign once the code is finished and verified. + +### Files to create + +- `paperforge/plugin/src/services/ocr-maintenance-ui.ts` + - Pure functions for mapping backend rows into user-facing categories, summary counts, and explanation strings. +- `paperforge/plugin/tests/ocr-maintenance-ui.test.ts` + - Unit coverage for the categorization and explanation rules. + +### Existing files to reference while implementing + +- `paperforge/worker/ocr_maintenance.py` + - Backend truth for `recommended_action`, `status`, `degraded_reasons`, and `error_summary`. +- `docs/superpowers/specs/2026-06-19-ocr-maintenance-ux-design.md` + - Approved design contract. + +--- + +### Task 1: Add a Pure UI Categorization Layer + +**Files:** +- Create: `paperforge/plugin/src/services/ocr-maintenance-ui.ts` +- Test: `paperforge/plugin/tests/ocr-maintenance-ui.test.ts` + +- [ ] **Step 1: Write the failing test for category mapping** + +```ts +import { describe, expect, it } from 'vitest'; +import { categorizeMaintenanceRow, buildMaintenanceSummary } from '../src/services/ocr-maintenance-ui'; + +describe('categorizeMaintenanceRow', () => { + it('maps rebuild recommendation to Rebuild Recommended', () => { + const result = categorizeMaintenanceRow({ + key: 'A1', + title: 'Paper A', + status: 'done_degraded', + health: 'yellow', + recommended_action: 'rebuild', + degraded_reasons: ['weak span coverage (62%)'], + error_summary: '', + error_stage: '', + version: 'v2', + finished_at: '06-19 10:00', + model: 'PaddleOCR-VL-1.6', + } as any); + + expect(result.category).toBe('rebuild'); + expect(result.label).toBe('Rebuild Recommended'); + expect(result.primaryAction).toBe('rebuild'); + }); + + it('maps failed OCR to OCR Failed and only then promotes rerun', () => { + const result = categorizeMaintenanceRow({ + key: 'B1', + title: 'Paper B', + status: 'failed', + health: '-', + recommended_action: 'redo', + degraded_reasons: [], + error_summary: 'timeout', + error_stage: 'poll', + version: 'v2', + finished_at: '06-19 11:00', + model: 'PaddleOCR-VL-1.6', + } as any); + + expect(result.category).toBe('failed'); + expect(result.label).toBe('OCR Failed'); + expect(result.primaryAction).toBe('redo'); + }); + + it('keeps non-actionable degraded papers in Result Limited', () => { + const result = categorizeMaintenanceRow({ + key: 'C1', + title: 'Paper C', + status: 'done_degraded', + health: 'yellow', + recommended_action: '', + degraded_reasons: ['weak body spine'], + error_summary: '', + error_stage: '', + version: 'v2', + finished_at: '06-19 12:00', + model: 'PaddleOCR-VL-1.6', + } as any); + + expect(result.category).toBe('limited'); + expect(result.label).toBe('Result Limited'); + expect(result.primaryAction).toBeNull(); + }); + + it('keeps clean completed rows in No Action Needed', () => { + const result = categorizeMaintenanceRow({ + key: 'D1', + title: 'Paper D', + status: 'done', + health: 'green', + recommended_action: '', + degraded_reasons: [], + error_summary: '', + error_stage: '', + version: 'v2', + finished_at: '06-19 13:00', + model: 'PaddleOCR-VL-1.6', + } as any); + + expect(result.category).toBe('ok'); + expect(result.label).toBe('No Action Needed'); + }); +}); + +describe('buildMaintenanceSummary', () => { + it('counts categories and builds the top-level verdict', () => { + const summary = buildMaintenanceSummary([ + { category: 'ok' }, + { category: 'rebuild' }, + { category: 'failed' }, + { category: 'limited' }, + ] as any); + + expect(summary.counts).toEqual({ ok: 1, rebuild: 1, failed: 1, limited: 1 }); + expect(summary.tone).toBe('warn'); + }); +}); +``` + +- [ ] **Step 2: Run test to verify it fails** + +Run: `npm test -- ocr-maintenance-ui.test.ts` +Expected: FAIL with `Cannot find module '../src/services/ocr-maintenance-ui'` or missing export errors. + +- [ ] **Step 3: Write the minimal implementation** + +```ts +export type MaintenanceCategory = 'ok' | 'rebuild' | 'failed' | 'limited'; +export type MaintenanceAction = 'rebuild' | 'redo' | null; + +export type MaintenanceRowLike = { + key: string; + title: string; + status: string; + health: string; + recommended_action: string; + degraded_reasons: string[]; + error_summary: string; + error_stage: string; + version: string; + finished_at: string; + model: string; +}; + +export function categorizeMaintenanceRow(row: MaintenanceRowLike) { + if (row.recommended_action === 'rebuild') { + return { + category: 'rebuild' as const, + label: 'Rebuild Recommended', + primaryAction: 'rebuild' as const, + reason: 'Derived OCR results can be regenerated from existing OCR data.', + }; + } + + if (row.status === 'failed') { + return { + category: 'failed' as const, + label: 'OCR Failed', + primaryAction: 'redo' as const, + reason: row.error_summary || 'OCR did not finish successfully.', + }; + } + + if ((row.degraded_reasons || []).length > 0 || row.status === 'done_degraded') { + return { + category: 'limited' as const, + label: 'Result Limited', + primaryAction: null, + reason: row.degraded_reasons?.[0] || 'This paper has weaker confidence signals, but no clear maintenance action is recommended.', + }; + } + + return { + category: 'ok' as const, + label: 'No Action Needed', + primaryAction: null, + reason: 'OCR results look usable and no maintenance action is recommended.', + }; +} + +export function buildMaintenanceSummary(items: Array<{ category: MaintenanceCategory }>) { + const counts = { ok: 0, rebuild: 0, failed: 0, limited: 0 }; + for (const item of items) counts[item.category] += 1; + const tone = counts.failed > 0 || counts.rebuild > 0 ? 'warn' : 'ok'; + return { counts, tone }; +} +``` + +- [ ] **Step 4: Run test to verify it passes** + +Run: `npm test -- ocr-maintenance-ui.test.ts` +Expected: PASS for the new categorization tests. + +- [ ] **Step 5: Commit** + +```bash +git add paperforge/plugin/src/services/ocr-maintenance-ui.ts paperforge/plugin/tests/ocr-maintenance-ui.test.ts +git commit -m "feat: add OCR maintenance UI categorization" +``` + +### Task 2: Replace Table-First Maintenance Rendering with Summary-First UX + +**Files:** +- Modify: `paperforge/plugin/src/settings.ts` +- Modify: `paperforge/plugin/src/i18n.ts` +- Test: `paperforge/plugin/tests/ocr-maintenance-ui.test.ts` + +- [ ] **Step 1: Extend tests to lock the user-facing explanation rules** + +```ts +it('uses rebuild-first copy for actionable items', () => { + const result = categorizeMaintenanceRow({ + key: 'R1', + title: 'Paper R', + status: 'done_degraded', + health: 'yellow', + recommended_action: 'rebuild', + degraded_reasons: ['weak span coverage (51%)'], + error_summary: '', + error_stage: '', + version: 'v2', + finished_at: '06-19 14:00', + model: 'PaddleOCR-VL-1.6', + } as any); + + expect(result.reason).toContain('existing OCR data'); +}); + +it('does not promote redo for non-failed rows', () => { + const result = categorizeMaintenanceRow({ + key: 'R2', + title: 'Paper R2', + status: 'done_degraded', + health: 'yellow', + recommended_action: 'redo', + degraded_reasons: ['weak body spine'], + error_summary: '', + error_stage: '', + version: 'v2', + finished_at: '06-19 14:10', + model: 'PaddleOCR-VL-1.6', + } as any); + + expect(result.category).toBe('limited'); + expect(result.primaryAction).toBeNull(); +}); +``` + +- [ ] **Step 2: Run tests to verify the new cases fail if the mapper is still too naive** + +Run: `npm test -- ocr-maintenance-ui.test.ts` +Expected: FAIL if `recommended_action === 'redo'` is still being promoted outside real failure states. + +- [ ] **Step 3: Update the mapper and build the new Maintenance tab sections** + +```ts +// settings.ts +import { + buildMaintenanceSummary, + categorizeMaintenanceRow, +} from './services/ocr-maintenance-ui'; + +// inside _renderMaintenanceTab callback, after rows load +const items = rows.map((row: any) => ({ row, ui: categorizeMaintenanceRow(row) })); +const summary = buildMaintenanceSummary(items.map(item => item.ui)); +const actionable = items.filter(item => item.ui.category === 'rebuild' || item.ui.category === 'failed'); +const limited = items.filter(item => item.ui.category === 'limited'); +const okItems = items.filter(item => item.ui.category === 'ok'); + +const hero = containerEl.createDiv({ cls: 'pf-maint-hero pf-card' }); +hero.createEl('h3', { text: summary.tone === 'warn' + ? `OCR needs attention: ${summary.counts.rebuild} rebuild, ${summary.counts.failed} failed.` + : 'OCR looks usable overall.' }); +hero.createEl('p', { + text: 'This page only promotes issues where maintenance is likely to help. Some papers may have limitations that maintenance will not improve.', + cls: 'setting-item-description', +}); + +const counts = hero.createDiv({ cls: 'pf-maint-counts' }); +for (const [label, value] of [ + ['No Action Needed', summary.counts.ok], + ['Rebuild Recommended', summary.counts.rebuild], + ['OCR Failed', summary.counts.failed], +]) { + const stat = counts.createDiv({ cls: 'pf-maint-stat' }); + stat.createEl('strong', { text: String(value) }); + stat.createEl('span', { text: label }); +} + +renderMaintenanceSection(containerEl, 'Needs Attention', actionable, { showPrimaryAction: true }); +renderMaintenanceSection(containerEl, 'Result Limitations', limited, { showPrimaryAction: false, intro: 'These papers look less certain, but PaperForge does not currently have a high-confidence maintenance action to recommend.' }); + +const advanced = containerEl.createEl('details', { cls: 'pf-maint-advanced' }); +advanced.createEl('summary', { text: `All Papers (${rows.length})` }); +renderMaintenanceTable(advanced, rows); +``` + +```ts +// i18n.ts +ocr_maint_title: 'Maintenance', +ocr_maint_hero_note: 'This page only promotes issues where maintenance is likely to help.', +ocr_maint_no_action: 'No Action Needed', +ocr_maint_rebuild: 'Rebuild Recommended', +ocr_maint_failed: 'OCR Failed', +ocr_maint_limited: 'Result Limited', +ocr_maint_rebuild_help: 'Rebuild regenerates OCR-derived results from existing OCR data. It does not call the OCR service again.', +ocr_maint_redo_help: 'Rerun OCR is only recommended when OCR clearly failed.', +``` + +- [ ] **Step 4: Run focused tests after the rendering refactor** + +Run: `npm test -- ocr-maintenance-ui.test.ts runtime.test.ts` +Expected: PASS with no regressions in the new helper behavior. + +- [ ] **Step 5: Commit** + +```bash +git add paperforge/plugin/src/settings.ts paperforge/plugin/src/i18n.ts paperforge/plugin/src/services/ocr-maintenance-ui.ts paperforge/plugin/tests/ocr-maintenance-ui.test.ts +git commit -m "feat: redesign OCR maintenance tab for actionability" +``` + +### Task 3: Style the New Sections and Preserve Advanced Table Access + +**Files:** +- Modify: `paperforge/plugin/styles.css` +- Modify: `paperforge/plugin/src/settings.ts` +- Test: `paperforge/plugin/tests/ocr-maintenance-ui.test.ts` + +- [ ] **Step 1: Add a minimal style smoke test target by keeping stable class names** + +```ts +// settings.ts class names used by CSS and future DOM assertions +'pf-maint-hero' +'pf-maint-counts' +'pf-maint-stat' +'pf-maint-section' +'pf-maint-card' +'pf-maint-chip' +'pf-maint-actions' +'pf-maint-details' +'pf-maint-advanced' +``` + +- [ ] **Step 2: Add the CSS for the summary-first layout** + +```css +.pf-maint-hero { + display: flex; + flex-direction: column; + gap: 10px; +} + +.pf-maint-counts { + display: grid; + grid-template-columns: repeat(auto-fit, minmax(120px, 1fr)); + gap: 10px; +} + +.pf-maint-stat { + background: var(--background-primary); + border: 1px solid var(--pf-border); + border-radius: var(--pf-radius); + padding: 10px; +} + +.pf-maint-section { + display: flex; + flex-direction: column; + gap: 10px; +} + +.pf-maint-card { + background: var(--pf-surface); + border: 1px solid var(--pf-border); + border-radius: var(--pf-radius); + padding: 12px; +} + +.pf-maint-chip { + display: inline-flex; + padding: 2px 8px; + border-radius: 999px; + font-size: 12px; + font-weight: 600; +} + +.pf-maint-chip--rebuild { background: color-mix(in srgb, var(--interactive-accent) 12%, transparent); } +.pf-maint-chip--failed { background: color-mix(in srgb, var(--text-error) 14%, transparent); } +.pf-maint-chip--limited { background: color-mix(in srgb, var(--text-warning) 14%, transparent); } +.pf-maint-chip--ok { background: color-mix(in srgb, var(--text-success) 14%, transparent); } + +.pf-maint-advanced summary { + cursor: pointer; + color: var(--text-muted); +} +``` + +- [ ] **Step 3: Keep the old full table renderer behind the advanced disclosure instead of deleting it** + +```ts +const advanced = containerEl.createEl('details', { cls: 'pf-maint-advanced' }); +advanced.createEl('summary', { text: `All Papers (${rows.length})` }); +const tableHost = advanced.createDiv(); +renderMaintenanceTable(tableHost, rows); +``` + +- [ ] **Step 4: Run the plugin test suite and rebuild the bundle** + +Run: `npm test && npm run build` +Expected: PASS for all Vitest files, then a successful `main.js` rebuild from esbuild. + +- [ ] **Step 5: Commit** + +```bash +git add paperforge/plugin/styles.css paperforge/plugin/src/settings.ts paperforge/plugin/main.js +git commit -m "feat: style OCR maintenance summary layout" +``` + +### Task 4: Verify End-to-End Behavior and Record the Change + +**Files:** +- Modify: `PROJECT-MANAGEMENT.md` +- Modify: `paperforge/plugin/main.js` + +- [ ] **Step 1: Manually verify the core UX paths in the plugin** + +```text +Check these states in the Maintenance tab: +1. No rows -> empty state still reads clearly. +2. Rebuild row -> appears under Needs Attention with rebuild-focused copy. +3. Failed row -> appears under Needs Attention with rerun OCR copy. +4. Degraded but non-actionable row -> appears under Result Limitations, not Needs Attention. +5. Full table -> still available inside All Papers disclosure. +``` + +- [ ] **Step 2: Run final verification commands** + +Run: `npm test && npm run build` +Expected: all plugin tests pass, TypeScript emits no errors, esbuild regenerates `main.js`. + +- [ ] **Step 3: Update the project log** + +```md +### 12.x OCR maintenance UX redesign (2026-06-19) + +- Problem: the plugin maintenance tab exposed raw OCR states and pushed ordinary users toward interpreting any warning as a repair task. +- Root cause: the UI was organized around backend table rows instead of actionability. +- Fix: added a UI-side categorization layer, promoted rebuild-only actionable items, limited redo promotion to true failures, and moved the full table into an advanced disclosure. +- Result: ordinary users now see a summary-first maintenance view that distinguishes actionable issues from non-actionable result limitations. +- Test status: `npm test && npm run build` in `paperforge/plugin`. +``` + +- [ ] **Step 4: Commit the verification and log update** + +```bash +git add PROJECT-MANAGEMENT.md paperforge/plugin/main.js +git commit -m "docs: record OCR maintenance UX redesign" +``` + +## Self-Review + +### Spec coverage + +- Summary-first judgment: covered by Task 2 hero + counts. +- Actionability-first categories: covered by Task 1 mapper. +- Rebuild promoted over redo: covered by Task 1 and Task 2 tests. +- Redo only for true failure: covered by Task 1 and Task 2 tests. +- Result Limited explanation without false repair pressure: covered by Task 2 section and copy. +- Full technical detail preserved behind disclosure: covered by Task 2 and Task 3 advanced table retention. + +### Placeholder scan + +- No `TBD`, `TODO`, or “similar to above” placeholders remain. +- Commands, files, and target code shapes are explicit. + +### Type consistency + +- Category vocabulary is consistent across tasks: `ok`, `rebuild`, `failed`, `limited`. +- Primary actions remain `rebuild | redo | null`. +- UI labels remain `No Action Needed`, `Rebuild Recommended`, `OCR Failed`, `Result Limited`. + +## Execution Handoff + +Plan complete and saved to `docs/superpowers/plans/2026-06-19-ocr-maintenance-ux-implementation.md`. Two execution options: + +**1. Subagent-Driven (recommended)** - I dispatch a fresh subagent per task, review between tasks, fast iteration + +**2. Inline Execution** - Execute tasks in this session using executing-plans, batch execution with checkpoints + +Which approach? diff --git a/docs/superpowers/plans/2026-06-19-ocr-rebuild-audit-remediation-implementation.md b/docs/superpowers/plans/2026-06-19-ocr-rebuild-audit-remediation-implementation.md new file mode 100644 index 00000000..eb91835b --- /dev/null +++ b/docs/superpowers/plans/2026-06-19-ocr-rebuild-audit-remediation-implementation.md @@ -0,0 +1,757 @@ +# OCR Rebuild Audit Remediation Implementation Plan + +> **For agentic workers:** REQUIRED SUB-SKILL: Use superpowers:subagent-driven-development (recommended) or superpowers:executing-plans to implement this plan task-by-task. Steps use checkbox (`- [ ]`) syntax for tracking. + +**Goal:** Remove the highest-value rebuild-output defects from the 452-paper audit without reopening OCR-v2 role-classification architecture or adding free-form text rescue logic. + +**Architecture:** Keep the anchor-first OCR-v2 backbone intact and harden only the post-structure surfaces: ownership write-through, render projection, figure/table inventory contracts, and additive health semantics. The plan starts with visible output pollution, then makes ownership authoritative, then tightens figure/table contracts, and only then adds backward-compatible health/reference semantics. + +**Tech Stack:** Python 3.14, `paperforge.worker` OCR pipeline, pytest, repo-local audit docs, existing OCR fixture/unit/regression tests. + +**Execution Status:** completed on `ocr-v2` via subagent-driven execution + +--- + +## File Structure + +- Modify: `paperforge/worker/ocr_tables.py` + - Owns table caption matching, table-asset ownership, table-note ownership, and consumed-table-block contract emission. +- Modify: `paperforge/worker/ocr_objects.py` + - Must consume owned table notes and render them into table object markdown. +- Modify: `paperforge/worker/ocr_render.py` + - Must skip already-consumed table-note blocks, stop duplicating table captions into fulltext, and tighten reference ordering. +- Modify: `paperforge/worker/ocr_health.py` + - Must add corrected counts and additive v2 semantics without breaking the current top-level surface. +- Modify: `paperforge/worker/ocr_figures.py` + - Owns figure namespace split, gated `page_assets`, and clearer ownership outcomes. +- Modify: `tests/test_ocr_tables.py` + - Table-note ownership and bare `Table N` contract coverage. +- Modify: `tests/test_ocr_objects.py` + - Table object markdown note rendering coverage. +- Modify: `tests/test_ocr_rendering.py` + - Fulltext table-caption suppression and consumed-note skipping coverage. +- Modify: `tests/test_ocr_figures.py` + - Namespace split and `page_assets` strict-gate coverage. +- Modify: `tests/test_ocr_health.py` + - Heading-count, `references_found`, and additive health-v2 field coverage. +- Modify: `PROJECT-MANAGEMENT.md` + - Record each landed remediation batch and any deliberately deferred hard cases. + +--- + +### Task 1: Make Table-Note Ownership Reach Object Markdown And Skip Body Flow + +**Files:** +- Modify: `paperforge/worker/ocr_tables.py` +- Modify: `paperforge/worker/ocr_objects.py` +- Modify: `paperforge/worker/ocr_render.py` +- Modify: `tests/test_ocr_tables.py` +- Modify: `tests/test_ocr_objects.py` +- Modify: `tests/test_ocr_rendering.py` + +- [ ] **Step 1: Add a failing table-inventory contract test for note payload and consumed ids** + +Append this test to `tests/test_ocr_tables.py` near the existing note-binding coverage: + +```python +def test_table_inventory_emits_note_payload_and_consumed_block_ids() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + { + "page": 5, + "block_id": "p5_a1", + "role": "table_asset", + "text": "table data", + "bbox": [100, 100, 600, 400], + }, + { + "page": 5, + "block_id": "p5_c1", + "role": "table_caption", + "text": "Table 1. Main results", + "bbox": [100, 420, 600, 460], + }, + { + "page": 5, + "block_id": "p5_n1", + "role": "footnote", + "raw_label": "vision_footnote", + "text": "* p < 0.05", + "bbox": [100, 405, 600, 425], + }, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + + assert table["note_block_ids"] == ["p5_n1"] + assert table["note_texts"] == ["* p < 0.05"] + assert set(table["consumed_block_ids"]) == {"p5_a1", "p5_c1", "p5_n1"} +``` + +- [ ] **Step 2: Add a failing table-object markdown test for rendered notes** + +Append this test to `tests/test_ocr_objects.py` after the existing table markdown coverage: + +```python +def test_table_object_markdown_renders_owned_notes() -> None: + from paperforge.worker.ocr_objects import render_table_object_markdown + + md = render_table_object_markdown( + { + "table_id": "table_001", + "page": 5, + "caption": "Table 1. Results.", + "image_relpath": "assets/tables/table_001.jpg", + "note_texts": ["* p < 0.05", "Data are mean ± SD."], + } + ) + + assert "## Notes" in md + assert "* p < 0.05" in md + assert "Data are mean ± SD." in md +``` + +- [ ] **Step 3: Add a failing fulltext test showing consumed note blocks do not render as body text** + +Append this test to `tests/test_ocr_rendering.py`: + +```python +def test_fulltext_skips_table_note_blocks_consumed_by_inventory() -> None: + from paperforge.worker.ocr_render import render_fulltext_markdown + + structured_blocks = [ + { + "page": 5, + "block_id": "p5_c1", + "role": "table_caption", + "text": "Table 1. Main results", + "bbox": [100, 420, 600, 460], + "zone": "display_zone", + "style_family": "table_caption_like", + }, + { + "page": 5, + "block_id": "p5_n1", + "role": "footnote", + "text": "* p < 0.05", + "bbox": [100, 405, 600, 425], + }, + ] + table_inventory = { + "tables": [ + { + "table_id": "table_001", + "page": 5, + "caption_block_id": "p5_c1", + "caption_text": "Table 1. Main results", + "asset_block_id": "p5_a1", + "note_block_ids": ["p5_n1"], + "note_texts": ["* p < 0.05"], + "consumed_block_ids": ["p5_a1", "p5_c1", "p5_n1"], + } + ] + } + + md = render_fulltext_markdown( + structured_blocks=structured_blocks, + resolved_metadata={}, + figure_inventory={"matched_figures": []}, + table_inventory=table_inventory, + page_count=5, + document_structure=None, + reader_payload={"figures": []}, + ) + + assert "* p < 0.05" not in md +``` + +- [ ] **Step 4: Run the targeted red tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "note_payload_and_consumed_block_ids" -v` + +Run: `python -m pytest tests/test_ocr_objects.py -k "renders_owned_notes" -v` + +Run: `python -m pytest tests/test_ocr_rendering.py -k "consumed_by_inventory" -v` + +Expected: all three FAIL because `note_texts` / `consumed_block_ids` / render skipping do not exist yet. + +- [ ] **Step 5: Implement the table-note ownership contract in `ocr_tables.py`** + +Update the table append block in `paperforge/worker/ocr_tables.py` so note text and consumed ids are emitted alongside ids: + +```python + note_block_ids: list[str] = [] + note_texts: list[str] = [] + if matched_asset: + asset_page = matched_asset.get("page", 0) + asset_bbox = matched_asset.get("bbox", [0, 0, 0, 0]) + asset_bottom = asset_bbox[3] if len(asset_bbox) >= 4 else 0 + for block in structured_blocks: + bpage = block.get("page", 0) + if bpage != asset_page: + continue + brole = str(block.get("role", "") or "") + braw_label = str(block.get("raw_label", "") or "").strip() + btext = str(block.get("text", "") or "").strip() + bbbox = block.get("bbox", [0, 0, 0, 0]) + if len(bbbox) < 4: + continue + is_note = brole == "footnote" or braw_label == "vision_footnote" + if not is_note: + continue + note_top = bbbox[1] + if asset_bottom <= note_top <= asset_bottom + 80: + note_block_ids.append(block.get("block_id", "")) + if btext: + note_texts.append(btext) + + consumed_block_ids = [caption.get("block_id", "")] + if matched_asset: + consumed_block_ids.append(matched_asset.get("block_id", "")) + consumed_block_ids.extend(note_block_ids) + consumed_block_ids = [bid for bid in consumed_block_ids if bid] + + tables.append( + { + "caption_block_id": caption.get("block_id", ""), + "page": caption_page, + "caption_text": caption_text, + "table_number": table_num, + "formal_table_number": formal_table_number, + "asset_block_id": matched_asset.get("block_id", "") if matched_asset else "", + "asset_bbox": matched_asset.get("bbox", [0, 0, 0, 0]) if matched_asset else [], + "has_asset": matched_asset is not None, + "note_block_ids": note_block_ids, + "note_texts": note_texts, + "consumed_block_ids": consumed_block_ids, + "match_status": match_status, + } + ) +``` + +- [ ] **Step 6: Implement note rendering in `ocr_objects.py`** + +Update `render_table_object_markdown()` in `paperforge/worker/ocr_objects.py`: + +```python +def render_table_object_markdown(table: dict[str, Any]) -> str: + caption = table.get("caption", "") + image_relpath = table.get("image_relpath", "") + note_texts = [normalize_ocr_math_text(t) for t in table.get("note_texts", []) if t] + formal_num = table.get("formal_table_number") + label = f"Table {formal_num}" if formal_num is not None else f"Table {table.get('table_id', 'unknown')}" + parts = [f"# {label}", "", f"![](../../{image_relpath})", ""] + if caption: + parts.append("## Caption") + parts.append(normalize_ocr_math_text(caption)) + if note_texts: + parts.append("") + parts.append("## Notes") + parts.extend(note_texts) + return "\n".join(parts) +``` + +- [ ] **Step 7: Implement consumed-note skipping in `ocr_render.py`** + +Near the existing consumed-caption handling in `render_fulltext_markdown()`, build consumed table block ids and skip them before body projection: + +```python + consumed_table_block_ids = set() + for table in table_inventory.get("tables", []): + for block_id in table.get("consumed_block_ids", []): + if block_id: + consumed_table_block_ids.add(block_id) + + block_id = block.get("block_id") + if block_id is not None and block_id in consumed_table_block_ids: + continue +``` + +- [ ] **Step 8: Re-run the targeted tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "note_payload_and_consumed_block_ids" -v` + +Run: `python -m pytest tests/test_ocr_objects.py -k "renders_owned_notes" -v` + +Run: `python -m pytest tests/test_ocr_rendering.py -k "consumed_by_inventory" -v` + +Expected: PASS. + +- [ ] **Step 9: Commit** + +```bash +git add paperforge/worker/ocr_tables.py paperforge/worker/ocr_objects.py paperforge/worker/ocr_render.py tests/test_ocr_tables.py tests/test_ocr_objects.py tests/test_ocr_rendering.py +git commit -m "fix: carry owned table notes through rebuild outputs" +``` + +--- + +### Task 2: Remove Table-Caption Duplication And Count All Heading Tiers + +**Files:** +- Modify: `paperforge/worker/ocr_render.py` +- Modify: `paperforge/worker/ocr_health.py` +- Modify: `tests/test_ocr_rendering.py` +- Modify: `tests/test_ocr_health.py` + +- [ ] **Step 1: Add a failing render test that display-zone table captions do not emit blockquotes** + +Append to `tests/test_ocr_rendering.py`: + +```python +def test_display_zone_table_caption_only_emits_embed_not_blockquote() -> None: + from paperforge.worker.ocr_render import render_fulltext_markdown + + structured_blocks = [ + { + "page": 5, + "block_id": "p5_c1", + "role": "table_caption", + "text": "Table 1. Main results", + "bbox": [100, 420, 600, 460], + "zone": "display_zone", + "style_family": "table_caption_like", + } + ] + table_inventory = { + "tables": [ + { + "table_id": "table_001", + "page": 5, + "caption_block_id": "p5_c1", + "caption_text": "Table 1. Main results", + "asset_block_id": "p5_a1", + "consumed_block_ids": ["p5_c1", "p5_a1"], + } + ] + } + + md = render_fulltext_markdown( + structured_blocks=structured_blocks, + resolved_metadata={}, + figure_inventory={"matched_figures": []}, + table_inventory=table_inventory, + page_count=5, + document_structure=None, + reader_payload={"figures": []}, + ) + + assert "> **Table 1. Main results**" not in md + assert "![[render/tables/table_001.md]]" in md +``` + +- [ ] **Step 2: Add a failing health test for multi-tier heading count and stricter references** + +Append to `tests/test_ocr_health.py`: + +```python +def test_health_counts_all_heading_tiers_and_requires_stronger_reference_evidence() -> None: + from paperforge.worker.ocr_health import build_ocr_health + + structured_blocks = [ + {"role": "section_heading", "text": "Intro"}, + {"role": "subsection_heading", "text": "Methods"}, + {"role": "sub_subsection_heading", "text": "2.1 Setup"}, + {"role": "body_paragraph", "raw_label": "reference_content", "text": "[1] weak raw label"}, + ] + + health = build_ocr_health( + page_count=1, + raw_blocks_count=4, + structured_blocks=structured_blocks, + figure_inventory={"matched_figures": [], "held_figures": [], "unmatched_legends": [], "unmatched_assets": [], "figure_legend_completeness": {}}, + table_inventory={"tables": [], "held_tables": [], "unmatched_captions": [], "unmatched_assets": []}, + doc_structure={"reference_zone": {"status": "HOLD"}}, + reader_payload=None, + rendered_markdown=None, + ) + + assert health["section_heading_count"] == 3 + assert health["references_found"] is False +``` + +- [ ] **Step 3: Run the targeted red tests** + +Run: `python -m pytest tests/test_ocr_rendering.py -k "table_caption_only_emits_embed" -v` + +Run: `python -m pytest tests/test_ocr_health.py -k "counts_all_heading_tiers" -v` + +Expected: FAIL. + +- [ ] **Step 4: Implement display-zone table-caption suppression in `ocr_render.py`** + +Replace the `table_caption` branch in `paperforge/worker/ocr_render.py` with a pure embed path for display-zone/table-caption-like tables: + +```python + elif role == "table_caption": + tbl_ids_for_page = tables_by_page.get(block_page, []) + if tbl_ids_for_page: + tbl_id = tbl_ids_for_page.pop(0) + lines.append(f"![[render/tables/{tbl_id}.md]]") + lines.append("") + elif text: + lines.append(f"### {text}") + lines.append("") +``` + +- [ ] **Step 5: Implement corrected heading and reference semantics in `ocr_health.py`** + +Update the health counters in `paperforge/worker/ocr_health.py`: + +```python + heading_roles = {"section_heading", "subsection_heading", "sub_subsection_heading"} + section_heading_count = sum(1 for b in structured_blocks if b.get("role") in heading_roles) + + reference_zone = (doc_structure or {}).get("reference_zone", {}) if isinstance(doc_structure, dict) else {} + reference_zone_status = str(reference_zone.get("status") or "") + reference_item_count = sum(1 for b in structured_blocks if b.get("role") == "reference_item") + references_found = reference_zone_status == "ACCEPT" or reference_item_count > 0 +``` + +- [ ] **Step 6: Re-run the targeted tests** + +Run: `python -m pytest tests/test_ocr_rendering.py -k "table_caption_only_emits_embed" -v` + +Run: `python -m pytest tests/test_ocr_health.py -k "counts_all_heading_tiers" -v` + +Expected: PASS. + +- [ ] **Step 7: Commit** + +```bash +git add paperforge/worker/ocr_render.py paperforge/worker/ocr_health.py tests/test_ocr_rendering.py tests/test_ocr_health.py +git commit -m "fix: clean table projection and health heading semantics" +``` + +--- + +### Task 3: Tighten Bare `Table N` Matching Without Text Rescue + +**Files:** +- Modify: `paperforge/worker/ocr_tables.py` +- Modify: `tests/test_ocr_tables.py` + +- [ ] **Step 1: Add a failing positive contract test for bare `Table N` under strong geometry** + +Append to `tests/test_ocr_tables.py`: + +```python +def test_bare_table_number_matches_when_geometry_and_table_evidence_are_strong() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + { + "page": 5, + "block_id": "p5_a1", + "role": "table_asset", + "raw_label": "table", + "bbox": [100, 100, 600, 400], + "text": "", + }, + { + "page": 5, + "block_id": "p5_c1", + "role": "table_caption", + "text": "Table 1", + "bbox": [100, 420, 600, 450], + }, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + assert table["has_asset"] is True + assert table["asset_block_id"] == "p5_a1" +``` + +- [ ] **Step 2: Add a failing negative contract test for nearby competing assets** + +Append to `tests/test_ocr_tables.py`: + +```python +def test_bare_table_number_stays_ambiguous_when_competing_assets_are_close() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + {"page": 5, "block_id": "p5_a1", "role": "table_asset", "raw_label": "table", "bbox": [100, 100, 430, 400], "text": ""}, + {"page": 5, "block_id": "p5_a2", "role": "table_asset", "raw_label": "table", "bbox": [450, 100, 780, 400], "text": ""}, + {"page": 5, "block_id": "p5_c1", "role": "table_caption", "text": "Table 1", "bbox": [100, 420, 780, 450]}, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + assert table["has_asset"] is False + assert table["match_status"] == "ambiguous" +``` + +- [ ] **Step 3: Run the red table tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "bare_table_number" -v` + +Expected: first FAILS because bare captions are currently treated as weak; second may FAIL if the implementation accepts too eagerly. + +- [ ] **Step 4: Implement a geometry-only exception for weak explicit table captions** + +Refactor the weak-caption path in `paperforge/worker/ocr_tables.py` so bare `Table N` can proceed only under the strict contract: + +```python +def _can_match_bare_table_number(caption: dict, top_candidate: dict | None, second_score: float) -> bool: + if top_candidate is None: + return False + if str(caption.get("role") or "") not in {"table_caption", "table_caption_candidate"} and not _is_validation_first_table_candidate(caption): + return False + if top_candidate.get("matched_asset_id") == "": + return False + if top_candidate.get("score", 0.0) < 0.75: + return False + if top_candidate.get("score", 0.0) - second_score < 0.2: + return False + evidence = set(top_candidate.get("evidence", [])) + return {"same_page", "x_overlap", "asset_above_caption"}.issubset(evidence) or {"previous_page_continuation", "x_overlap"}.issubset(evidence) +``` + +Then use that helper instead of unconditional weak-caption rejection. + +- [ ] **Step 5: Re-run the bare-caption tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "bare_table_number" -v` + +Expected: PASS. + +- [ ] **Step 6: Commit** + +```bash +git add paperforge/worker/ocr_tables.py tests/test_ocr_tables.py +git commit -m "fix: gate bare table-number matching on strong geometry" +``` + +--- + +### Task 4: Split Figure Namespace And Gate `page_assets` + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` +- Modify: `tests/test_ocr_figures.py` +- Modify: `tests/test_ocr_real_paper_regressions.py` + +- [ ] **Step 1: Add a failing unit test for namespace separation** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_main_and_supplementary_figures_do_not_dedup_into_one_number() -> None: + from paperforge.worker.ocr_figures import build_figure_inventory + + structured_blocks = [ + {"page": 3, "block_id": "p3_c1", "role": "figure_caption", "text": "Figure 1. Main figure.", "bbox": [100, 420, 600, 460]}, + {"page": 3, "block_id": "p3_a1", "role": "figure_asset", "bbox": [100, 100, 600, 400], "text": ""}, + {"page": 4, "block_id": "p4_c1", "role": "figure_caption", "text": "Supplementary Figure S1. Supplement.", "bbox": [100, 420, 600, 460]}, + {"page": 4, "block_id": "p4_a1", "role": "figure_asset", "bbox": [100, 100, 600, 400], "text": ""}, + ] + + inventory = build_figure_inventory(structured_blocks) + figure_ids = {fig["figure_id"] for fig in inventory["matched_figures"]} + assert "figure_001" in figure_ids + assert "figure_s001" in figure_ids +``` + +- [ ] **Step 2: Add a failing unit test that `page_assets` does not strict-match when competing captions exist** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_page_assets_group_does_not_strict_match_when_page_has_competing_captions() -> None: + from paperforge.worker.ocr_figures import build_figure_inventory + + structured_blocks = [ + {"page": 5, "block_id": "p5_a1", "role": "figure_asset", "raw_label": "image", "bbox": [100, 100, 300, 260], "text": ""}, + {"page": 5, "block_id": "p5_a2", "role": "figure_asset", "raw_label": "image", "bbox": [320, 100, 520, 260], "text": ""}, + {"page": 5, "block_id": "p5_a3", "role": "figure_asset", "raw_label": "image", "bbox": [540, 100, 740, 260], "text": ""}, + {"page": 5, "block_id": "p5_c1", "role": "figure_caption", "text": "Figure 1. Left.", "bbox": [100, 280, 320, 320], "zone": "display_zone", "style_family": "legend_like"}, + {"page": 5, "block_id": "p5_c2", "role": "figure_caption", "text": "Figure 2. Right.", "bbox": [420, 280, 740, 320], "zone": "display_zone", "style_family": "legend_like"}, + ] + + inventory = build_figure_inventory(structured_blocks) + assert all("page_assets_group" not in fig.get("confidence_reason", "") for fig in inventory["matched_figures"]) +``` + +- [ ] **Step 3: Run the red figure tests** + +Run: `python -m pytest tests/test_ocr_figures.py -k "supplementary_figures_do_not_dedup or page_assets_group_does_not_strict_match" -v` + +Expected: FAIL. + +- [ ] **Step 4: Implement namespace-aware figure identity in `ocr_figures.py`** + +Introduce a namespace extractor and use it in id/dedup logic: + +```python +def _extract_figure_namespace(text: str) -> str: + lower = text.lower() + if "supplementary" in lower: + return "supplementary" + if "extended data" in lower: + return "extended_data" + return "main" + + +def _format_figure_id(namespace: str, number: int) -> str: + if namespace == "supplementary": + return f"figure_s{number:03d}" + if namespace == "extended_data": + return f"figure_ed{number:03d}" + return f"figure_{number:03d}" +``` + +Then replace integer-only dedup keys with `(namespace, number)` tuples. + +- [ ] **Step 5: Gate `page_assets` strict matching** + +In `paperforge/worker/ocr_figures.py`, only allow `page_assets` to return a strict matched score when one of the explicit gates is true; otherwise return a reader-level/non-strict decision: + +```python + if gt == "page_assets": + if not group.get("strict_page_assets_ok", False): + return { + "score": 0.0, + "decision": "grouped_evidence_only", + "evidence": ["same_page", "page_assets_group", "non_strict_only"], + } +``` + +Populate `strict_page_assets_ok` when: + +- there is exactly one formal figure legend on the page, or +- expected panel count closely matches asset count, or +- no competing figure/table captions exist on the page. + +- [ ] **Step 6: Re-run the targeted figure tests** + +Run: `python -m pytest tests/test_ocr_figures.py -k "supplementary_figures_do_not_dedup or page_assets_group_does_not_strict_match" -v` + +Expected: PASS. + +- [ ] **Step 7: Run the existing real-paper regression protecting against page swallowing** + +Run: `python -m pytest tests/test_ocr_real_paper_regressions.py -k "mega_merges_same_page_assets" -v` + +Expected: PASS. + +- [ ] **Step 8: Commit** + +```bash +git add paperforge/worker/ocr_figures.py tests/test_ocr_figures.py tests/test_ocr_real_paper_regressions.py +git commit -m "fix: split figure namespace and gate page asset grouping" +``` + +--- + +### Task 5: Add Health V2 Fields And Land The Batch Documentation Update + +**Files:** +- Modify: `paperforge/worker/ocr_health.py` +- Modify: `tests/test_ocr_health.py` +- Modify: `PROJECT-MANAGEMENT.md` + +- [ ] **Step 1: Add a failing health-v2 test for additive fields** + +Append to `tests/test_ocr_health.py`: + +```python +def test_health_emits_additive_v2_fields_without_replacing_overall() -> None: + from paperforge.worker.ocr_health import build_ocr_health + + health = build_ocr_health( + page_count=1, + raw_blocks_count=0, + structured_blocks=[{"role": "section_heading", "text": "Intro"}], + figure_inventory={"matched_figures": [], "held_figures": [], "unmatched_legends": [], "unmatched_assets": [], "figure_legend_completeness": {}}, + table_inventory={"tables": [], "held_tables": [], "unmatched_captions": [], "unmatched_assets": []}, + doc_structure={"reference_zone": {"status": "ACCEPT"}}, + reader_payload=None, + rendered_markdown=None, + ) + + assert "overall" in health + assert "heading_total_v2" in health + assert "matched_figure_count_v2" in health + assert "issue_breakdown_v2" in health +``` + +- [ ] **Step 2: Run the red test** + +Run: `python -m pytest tests/test_ocr_health.py -k "emits_additive_v2_fields" -v` + +Expected: FAIL. + +- [ ] **Step 3: Implement additive v2 fields in `ocr_health.py`** + +Add the corrected fields near the existing return payload in `paperforge/worker/ocr_health.py`: + +```python + issue_breakdown_v2 = { + "caption_without_media": caption_without_media, + "media_without_caption": media_without_caption, + "empty_tables": empty_tables, + "abstract_found": abstract_found, + "references_found": references_found, + "heading_total": section_heading_count, + "formal_legend_gaps": formal_legend_gaps, + } + + return { + "overall": overall, + "section_heading_count": section_heading_count, + "references_found": references_found, + "heading_total_v2": section_heading_count, + "matched_figure_count_v2": len(figure_inventory.get("matched_figures", [])), + "issue_breakdown_v2": issue_breakdown_v2, + "figure_asset_count": figure_asset_count, + } +``` + +- [ ] **Step 4: Re-run the targeted v2 health test** + +Run: `python -m pytest tests/test_ocr_health.py -k "emits_additive_v2_fields" -v` + +Expected: PASS. + +- [ ] **Step 5: Record the completed remediation batches in `PROJECT-MANAGEMENT.md`** + +Append a new section using the repo’s established format: + +```md +### 11.2 OCR Rebuild Audit Remediation Batch 1 (2026-06-19) + +**Problem:** Full rebuild outputs still leaked owned table notes into body flow, duplicated table captions in fulltext, and overstated health defects through weak heading/reference semantics. + +**Root cause:** Ownership evidence stopped at inventory fields; render and health still relied on shallow projection/proxy logic. + +**Fix:** Carried table-note ownership through inventory/object/render surfaces, removed display-zone table-caption duplication, counted all heading tiers, and added additive health-v2 counters. + +**Result:** Fulltext is cleaner, table objects retain owned notes, and health artifacts are more interpretable without replacing the top-level compatibility surface. + +**Test status:** `python -m pytest tests/test_ocr_tables.py tests/test_ocr_objects.py tests/test_ocr_rendering.py tests/test_ocr_figures.py tests/test_ocr_health.py -v --tb=short` +``` + +- [ ] **Step 6: Run the focused regression suite for this plan slice** + +Run: `python -m pytest tests/test_ocr_tables.py tests/test_ocr_objects.py tests/test_ocr_rendering.py tests/test_ocr_figures.py tests/test_ocr_health.py -v --tb=short` + +Expected: PASS. + +- [ ] **Step 7: Commit** + +```bash +git add paperforge/worker/ocr_health.py tests/test_ocr_health.py PROJECT-MANAGEMENT.md +git commit -m "feat: add additive rebuild health semantics" +``` + +--- + +## Self-Review Notes + +- Spec coverage: this plan covers Phase A pollution fixes, ownership write-through, bare `Table N` hardening, namespace split, `page_assets` gates, and additive health-v2 semantics. +- Intentional deferral: full figure/table cross-arbitration beyond current inventory seams and major overall-score replacement are not included here. +- No placeholders rule: all code steps, tests, commands, doc edits, and project-management text are specified directly. diff --git a/docs/superpowers/plans/2026-06-19-ocr-truth-surface-realignment-implementation.md b/docs/superpowers/plans/2026-06-19-ocr-truth-surface-realignment-implementation.md new file mode 100644 index 00000000..46c9aa7a --- /dev/null +++ b/docs/superpowers/plans/2026-06-19-ocr-truth-surface-realignment-implementation.md @@ -0,0 +1,337 @@ +# OCR Truth Surface Realignment Implementation Plan + +> **For agentic workers:** REQUIRED SUB-SKILL: Use superpowers:subagent-driven-development (recommended) or superpowers:executing-plans to implement this plan task-by-task. Steps use checkbox (`- [ ]`) syntax for tracking. + +**Goal:** Make the OCR-v2 truth surface coherent by distinguishing completed readiness-gate status from the active post-readiness rebuild-hardening queue. + +**Architecture:** Keep the change narrow. Do not rewrite historical analysis bodies. Change only headers, status lines, active-queue wording, cross-links, and contradictory phrases so one active queue governs execution while the rebuild audit becomes the evidence source and historical readiness files are explicitly frozen. + +**Tech Stack:** Markdown docs in `project/current/` and repo root, pytest for doc-contract assertions, existing OCR project truth files. + +**Execution Status:** completed on `ocr-v2` via subagent-driven execution + +--- + +## File Structure + +- Create: `tests/test_ocr_truth_surface_docs.py` + - Doc-contract guard for active queue, historical residual labeling, and contradiction phrases. +- Modify or Create: `project/current/ocr-v2-active-queue.md` + - Preferred clean active queue file if introducing a new name is acceptable. +- Modify: `project/current/ocr-v2-closeout-priority.md` + - Either becomes a transitional pointer or is frozen as historical closeout context. +- Modify: `project/current/ocr-v2-generalization-boundary.md` + - Remains the broader architecture note, not the active queue. +- Modify: `project/current/ocr-v2-remaining-issues-2026-06-18.md` + - Freeze as readiness-cycle residuals. +- Modify: `project/current/ocr_rebuild_audit.md` + - Mark explicitly as post-readiness rebuild-hardening evidence. +- Modify: `PROJECT-MANAGEMENT.md` + - Record the narrative handoff and point to the active queue. + +--- + +### Task 1: Install A Truth-Surface Doc Contract Test Before Editing Docs + +**Files:** +- Create: `tests/test_ocr_truth_surface_docs.py` + +- [ ] **Step 1: Write a failing doc-contract test file** + +Create `tests/test_ocr_truth_surface_docs.py` with this content: + +```python +from __future__ import annotations + +from pathlib import Path + + +ROOT = Path(__file__).resolve().parents[1] +ACTIVE_QUEUE = ROOT / "project" / "current" / "ocr-v2-active-queue.md" +GENERALIZATION = ROOT / "project" / "current" / "ocr-v2-generalization-boundary.md" +REMAINING = ROOT / "project" / "current" / "ocr-v2-remaining-issues-2026-06-18.md" +REBUILD_AUDIT = ROOT / "project" / "current" / "ocr_rebuild_audit.md" +PM = ROOT / "PROJECT-MANAGEMENT.md" + + +def _text(path: Path) -> str: + return path.read_text(encoding="utf-8") + + +def test_active_queue_file_exists_and_declares_post_readiness_role() -> None: + text = _text(ACTIVE_QUEUE) + assert "ACTIVE QUEUE" in text + assert "post-readiness rebuild hardening" in text + + +def test_rebuild_audit_declares_it_is_an_evidence_surface() -> None: + text = _text(REBUILD_AUDIT) + assert "post-readiness audit surface" in text + assert "evidence source" in text + + +def test_remaining_issues_file_is_frozen_as_readiness_cycle_residuals() -> None: + text = _text(REMAINING) + assert "readiness-cycle residuals" in text + + +def test_project_management_points_to_active_queue_not_itself() -> None: + text = _text(PM) + assert "active queue" in text + assert "ocr-v2-active-queue.md" in text + + +def test_no_active_truth_file_claims_nothing_remains() -> None: + for path in [ACTIVE_QUEUE, GENERALIZATION, REMAINING, REBUILD_AUDIT, PM]: + text = _text(path).lower() + assert "nothing remains" not in text + assert "merge now" not in text +``` + +- [ ] **Step 2: Run the red doc-contract test** + +Run: `python -m pytest tests/test_ocr_truth_surface_docs.py -v` + +Expected: FAIL because `ocr-v2-active-queue.md` does not exist yet and the current files do not carry the new contract language. + +- [ ] **Step 3: Commit the guardrail test** + +```bash +git add tests/test_ocr_truth_surface_docs.py +git commit -m "test: add OCR truth surface doc contract guard" +``` + +--- + +### Task 2: Create The Active Queue File And Freeze The Old Queue Vocabulary + +**Files:** +- Create: `project/current/ocr-v2-active-queue.md` +- Modify: `project/current/ocr-v2-closeout-priority.md` + +- [ ] **Step 1: Create the new active queue file** + +Create `project/current/ocr-v2-active-queue.md` with this content: + +```md +# OCR-v2 Active Queue + +> Status: ACTIVE QUEUE — post-readiness rebuild hardening +> Last updated: 2026-06-19 +> Scope: authoritative next-work queue for OCR after readiness-gate completion + +## Queue Contract + +OCR-v2 architecture readiness is complete. +Post-readiness rebuild hardening is now the active queue. +This file governs next execution when other OCR truth files disagree. + +## Current Priorities + +1. Rebuild-output pollution fixes +2. Ownership write-through fixes +3. Figure/table inventory contract hardening +4. Additive health-v2 semantics + +## Cross-Links + +- Evidence source: `project/current/ocr_rebuild_audit.md` +- Architecture boundary note: `project/current/ocr-v2-generalization-boundary.md` +- Historical readiness residuals: `project/current/ocr-v2-remaining-issues-2026-06-18.md` +- Narrative ledger: `PROJECT-MANAGEMENT.md` +``` + +- [ ] **Step 2: Freeze the old closeout file as non-authoritative** + +Replace the header and next-work section at the top of `project/current/ocr-v2-closeout-priority.md` so it becomes a transitional historical pointer, for example: + +```md +# OCR-v2 Close-Out Priority + +> Status: historical closeout queue — superseded by `project/current/ocr-v2-active-queue.md` +> Last updated: 2026-06-19 +> Former role: authoritative readiness / closeout queue + +## Status + +This file records the final closeout/readiness queue state that led into post-readiness rebuild hardening. +It no longer governs next execution. + +## Current Authority + +Use `project/current/ocr-v2-active-queue.md` for active OCR work. +``` + +- [ ] **Step 3: Run the doc-contract test again** + +Run: `python -m pytest tests/test_ocr_truth_surface_docs.py -k "active_queue_file_exists" -v` + +Expected: PASS for the active-queue existence contract. + +- [ ] **Step 4: Commit** + +```bash +git add project/current/ocr-v2-active-queue.md project/current/ocr-v2-closeout-priority.md +git commit -m "docs: add OCR active queue and freeze closeout queue" +``` + +--- + +### Task 3: Relabel The Remaining Truth Files Without Rewriting Their Analysis Bodies + +**Files:** +- Modify: `project/current/ocr-v2-generalization-boundary.md` +- Modify: `project/current/ocr-v2-remaining-issues-2026-06-18.md` +- Modify: `project/current/ocr_rebuild_audit.md` +- Modify: `PROJECT-MANAGEMENT.md` + +- [ ] **Step 1: Update the broader architecture note header and next-actions lines** + +Edit only the control-plane surfaces in `project/current/ocr-v2-generalization-boundary.md`: + +```md +> Status: broader architecture note +> Readiness status: complete +> Active execution queue: `project/current/ocr-v2-active-queue.md` +``` + +Replace the current `Next Actions` section with a short pointer section: + +```md +## Queue Relationship + +This file is the broader architecture note. +It does not govern day-to-day execution. +Use `project/current/ocr-v2-active-queue.md` for active work and `project/current/ocr_rebuild_audit.md` for rebuild-hardening evidence. +``` + +- [ ] **Step 2: Freeze the readiness residual file explicitly** + +Edit only the header and top summary in `project/current/ocr-v2-remaining-issues-2026-06-18.md`: + +```md +> Status: historical readiness-cycle residuals +> Readiness gates: complete +> Active queue: `project/current/ocr-v2-active-queue.md` +``` + +Add a short note below the header: + +```md +This file records the residual state at the end of the readiness-gate cycle. +It is not the active rebuild-hardening queue. +``` + +- [ ] **Step 3: Mark the rebuild audit as evidence source, not architecture repudiation** + +Edit only the top section of `project/current/ocr_rebuild_audit.md`: + +```md +> Status: post-readiness audit surface +> Role: evidence source for rebuild hardening +> Does not change: the completed OCR-v2 readiness-gate conclusion +``` + +Add a short intro paragraph: + +```md +This audit evaluates rebuild outputs across the broader corpus after readiness-gate completion. +It identifies post-readiness hardening work; it does not reopen the OCR-v2 backbone decision. +``` + +- [ ] **Step 4: Add a narrative handoff section to `PROJECT-MANAGEMENT.md`** + +Insert a new section near the top of `PROJECT-MANAGEMENT.md`: + +```md +### 0.3 Truth-Surface Handoff + +OCR-v2 readiness-gate work is complete. +Post-readiness rebuild hardening is now the active queue. + +Execution authority: +- Active queue: `project/current/ocr-v2-active-queue.md` +- Evidence source: `project/current/ocr_rebuild_audit.md` +- Broader architecture note: `project/current/ocr-v2-generalization-boundary.md` +- Historical readiness residuals: `project/current/ocr-v2-remaining-issues-2026-06-18.md` + +`PROJECT-MANAGEMENT.md` records the handoff but does not override the active queue. +``` + +- [ ] **Step 5: Run the full doc-contract test** + +Run: `python -m pytest tests/test_ocr_truth_surface_docs.py -v` + +Expected: PASS. + +- [ ] **Step 6: Commit** + +```bash +git add project/current/ocr-v2-generalization-boundary.md project/current/ocr-v2-remaining-issues-2026-06-18.md project/current/ocr_rebuild_audit.md PROJECT-MANAGEMENT.md +git commit -m "docs: realign OCR truth surface roles" +``` + +--- + +### Task 4: Run The Contradiction Pass And Normalize Cross-Links + +**Files:** +- Modify: `project/current/ocr-v2-active-queue.md` +- Modify: `project/current/ocr-v2-closeout-priority.md` +- Modify: `project/current/ocr-v2-generalization-boundary.md` +- Modify: `project/current/ocr-v2-remaining-issues-2026-06-18.md` +- Modify: `project/current/ocr_rebuild_audit.md` +- Modify: `PROJECT-MANAGEMENT.md` + +- [ ] **Step 1: Search for contradiction phrases in the active truth surface** + +Run: `rg -n "merge now|nothing remains|all done|final remaining|active remaining issues|readiness incomplete|reopen architecture" PROJECT-MANAGEMENT.md project/current/ocr-v2-active-queue.md project/current/ocr-v2-closeout-priority.md project/current/ocr-v2-generalization-boundary.md project/current/ocr-v2-remaining-issues-2026-06-18.md project/current/ocr_rebuild_audit.md` + +Expected: one or more hits that require reclassification or removal. + +- [ ] **Step 2: For each hit, classify and rewrite only the contradictory control-plane wording** + +Apply this rubric while editing: + +```text +If the phrase is a historical readiness statement, preserve the analysis body and relabel it as historical. +If the phrase pretends to be current execution authority, replace it with a pointer to ocr-v2-active-queue.md. +If the phrase implies the architecture is incomplete because rebuild hardening exists, rewrite it to distinguish the two evaluation surfaces. +``` + +- [ ] **Step 3: Add consistent cross-links at the top of each active file** + +Ensure each file’s top section includes a compact link set such as: + +```md +- Active queue: `project/current/ocr-v2-active-queue.md` +- Evidence source: `project/current/ocr_rebuild_audit.md` +- Architecture boundary: `project/current/ocr-v2-generalization-boundary.md` +``` + +- [ ] **Step 4: Re-run the contradiction grep** + +Run the same `rg` command from Step 1. + +Expected: only acceptable historical-context hits remain, or no hits remain. + +- [ ] **Step 5: Re-run the doc-contract test** + +Run: `python -m pytest tests/test_ocr_truth_surface_docs.py -v` + +Expected: PASS. + +- [ ] **Step 6: Commit** + +```bash +git add PROJECT-MANAGEMENT.md project/current/ocr-v2-active-queue.md project/current/ocr-v2-closeout-priority.md project/current/ocr-v2-generalization-boundary.md project/current/ocr-v2-remaining-issues-2026-06-18.md project/current/ocr_rebuild_audit.md +git commit -m "docs: remove OCR truth surface contradictions" +``` + +--- + +## Self-Review Notes + +- Spec coverage: this plan establishes one active queue, distinguishes evidence source vs queue vs architecture note vs historical residuals, constrains edits to control-plane surfaces, and adds an explicit contradiction pass. +- Narrow-scope guarantee: no task rewrites historical analysis bodies; all edits are limited to headers, status sections, next-work sections, and cross-links. +- Plan split: this is intentionally separate from rebuild/output code remediation and should be executed before large remediation batches so future workers read the right queue. diff --git a/docs/superpowers/plans/2026-06-20-reference-zone-and-ownership-hardening-implementation.md b/docs/superpowers/plans/2026-06-20-reference-zone-and-ownership-hardening-implementation.md new file mode 100644 index 00000000..9b53a867 --- /dev/null +++ b/docs/superpowers/plans/2026-06-20-reference-zone-and-ownership-hardening-implementation.md @@ -0,0 +1,725 @@ +# Reference Zone And Ownership Hardening Implementation Plan + +> **For agentic workers:** REQUIRED SUB-SKILL: Use superpowers:subagent-driven-development (recommended) or superpowers:executing-plans to implement this plan task-by-task. Steps use checkbox (`- [ ]`) syntax for tracking. + +**Goal:** Add a shared layout-facts layer that improves reference-zone containment and figure/table ownership on untouched OCR papers without reopening OCR-v2 role classification. + +**Architecture:** Keep the existing OCR-v2 pipeline and strengthen it in place. First compute lightweight layout facts after document normalization, then consume those facts in two downstream paths: a practical reference corridor that optimizes for clean containment, and a cluster-first ownership path that treats bridgeable empty gaps as display continuity rather than hard separators. + +**Tech Stack:** Python 3.14, existing `paperforge.worker` OCR pipeline, pytest, real-paper regressions, existing audit helpers under `.opencode/skills/paperforge-development/`. + +--- + +## File Structure + +- Modify: `paperforge/worker/ocr_document.py` + - Own the shared layout-facts layer, reference corridor scoring, and local entry reconstruction hooks. +- Create: `paperforge/worker/ocr_reference_signals.py` + - Own coarse reference-family scoring, journal-abbreviation support, and block/entry-level style signals. +- Create: `paperforge/resources/nlm_journal_abbreviations.json` + - Compact biomedical journal abbreviation lexicon used as strong positive evidence only. +- Modify: `paperforge/worker/ocr_figures.py` + - Own display-cluster construction, bridge-aware grouping, and ownership validation for figures. +- Modify: `paperforge/worker/ocr_tables.py` + - Reuse display-cluster facts for table ownership and prevent empty-gap fragmentation on irregular table pages. +- Modify: `paperforge/worker/ocr_structural_gate.py` + - Ensure `HOLD` reference candidates stop contaminating accepted reference membership. +- Modify: `paperforge/worker/ocr_health.py` + - Consume accepted outcomes only where health logic needs the hardened reference/ownership surfaces. +- Test: `tests/test_ocr_document.py` + - Unit coverage for shared layout facts, reference corridor anti-intrusion, and local entry reconstruction. +- Test: `tests/test_ocr_layout_zones.py` + - Zone-oriented regression coverage for mixed body/reference/tail pages. +- Test: `tests/test_ocr_figures.py` + - Bridge-aware display-cluster and validation coverage for irregular figure layouts. +- Test: `tests/test_ocr_tables.py` + - Bridge-aware table ownership coverage on sparse and empty-gap pages. +- Test: `tests/test_ocr_pdf_text_fallback.py` + - Local PDF text fallback boundary coverage. +- Test: `tests/test_ocr_real_paper_regressions.py` + - Untouched-paper protection for reference and ownership hardening. +- Update: `PROJECT-MANAGEMENT.md` + - Record the hardening slice, measured impact, and any deliberately deferred edge cases. + +Per repo policy, do not create git commits unless the user explicitly requests them. + +--- + +### Task 1: Add Shared Layout Facts Before Specialized Consumers + +**Files:** +- Modify: `paperforge/worker/ocr_document.py` +- Test: `tests/test_ocr_document.py` +- Test: `tests/test_ocr_layout_zones.py` + +- [ ] **Step 1: Write the failing shared-layout-facts unit test** + +Add to `tests/test_ocr_document.py`: + +```python +def test_compute_layout_facts_marks_reading_band_region_boundary_and_bridge() -> None: + from paperforge.worker.ocr_document import compute_layout_facts + + blocks = [ + { + "block_id": "body_1", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "bbox": [80, 120, 520, 220], + "text": "Body text.", + }, + { + "block_id": "ref_1", + "page": 5, + "role": "reference_item", + "zone": "reference_zone", + "bbox": [610, 120, 1120, 180], + "text": "Smith J, Doe P. J Bone Miner Res. 2021;36(4):100-110.", + }, + { + "block_id": "gap_1", + "page": 5, + "role": "unknown_structural", + "zone": "display_zone", + "bbox": [640, 200, 1110, 360], + "text": "", + }, + ] + + facts = compute_layout_facts(blocks) + by_id = {row["block_id"]: row for row in facts} + + assert by_id["body_1"]["layout_region"] == "body_flow" + assert by_id["ref_1"]["layout_region"] == "reference_candidate" + assert by_id["body_1"]["reading_band_id"] != by_id["ref_1"]["reading_band_id"] + assert by_id["gap_1"]["bridge_eligible"] is True + assert by_id["ref_1"]["boundary_before"] in {"weak", "hard"} +``` + +- [ ] **Step 2: Run the targeted tests to verify they fail** + +Run: `python -m pytest tests/test_ocr_document.py -k "compute_layout_facts" -v --tb=short` + +Expected: FAIL with import or missing function errors. + +- [ ] **Step 3: Implement the minimal shared-layout-facts helper** + +Add near layout/document helpers in `paperforge/worker/ocr_document.py`: + +```python +def compute_layout_facts(blocks: list[dict]) -> list[dict]: + facts: list[dict] = [] + band_seq = 0 + last_key: tuple[int, str, int] | None = None + for block in sorted(blocks, key=lambda b: (int(b.get("page", 0) or 0), (b.get("bbox") or [0, 0, 0, 0])[0], (b.get("bbox") or [0, 0, 0, 0])[1])): + page = int(block.get("page", 0) or 0) + bbox = block.get("bbox") or [0, 0, 0, 0] + role = str(block.get("role") or "") + zone = str(block.get("zone") or "") + text = str(block.get("text") or block.get("block_content") or "").strip() + if zone == "reference_zone" or role in {"reference_heading", "reference_item"}: + layout_region = "reference_candidate" + elif zone == "display_zone" or role in {"figure_asset", "media_asset", "table_html", "figure_caption", "table_caption"}: + layout_region = "display_zone" + elif zone in {"tail_nonref_hold_zone", "post_reference_backmatter_zone"} or role.startswith("backmatter"): + layout_region = "tail_candidate" + elif zone in {"frontmatter_side_zone", "frontmatter_main_zone"} and role in {"structured_insert", "structured_insert_candidate", "non_body_insert"}: + layout_region = "side_insert" + else: + layout_region = "body_flow" + col_key = 0 if len(bbox) < 4 else (0 if bbox[0] < 600 else 1) + key = (page, layout_region, col_key) + if key != last_key: + band_seq += 1 + last_key = key + facts.append( + { + "block_id": str(block.get("block_id") or ""), + "reading_band_id": f"band_{band_seq:03d}", + "display_cluster_candidate_id": f"disp_{page}_{col_key}" if layout_region == "display_zone" else "", + "layout_region": layout_region, + "boundary_before": "hard" if layout_region in {"reference_candidate", "display_zone"} and role not in {"reference_item", "figure_asset", "media_asset", "table_html"} else "none", + "boundary_after": "none", + "bridge_eligible": role == "unknown_structural" and not text and layout_region == "display_zone", + } + ) + return facts +``` + +- [ ] **Step 4: Attach layout facts to the normalized block flow** + +In the normalization flow in `paperforge/worker/ocr_document.py`, after blocks have stable `role` and `zone`, add: + +```python + layout_facts = compute_layout_facts(blocks) + fact_by_id = {row["block_id"]: row for row in layout_facts if row.get("block_id")} + for block in blocks: + block_id = str(block.get("block_id") or "") + fact = fact_by_id.get(block_id) + if not fact: + continue + block["reading_band_id"] = fact["reading_band_id"] + block["display_cluster_candidate_id"] = fact["display_cluster_candidate_id"] + block["layout_region"] = fact["layout_region"] + block["boundary_before"] = fact["boundary_before"] + block["boundary_after"] = fact["boundary_after"] + block["bridge_eligible"] = fact["bridge_eligible"] +``` + +- [ ] **Step 5: Add one zone regression for mixed same-page content** + +Add to `tests/test_ocr_layout_zones.py`: + +```python +def test_layout_facts_split_body_and_reference_candidates_on_same_page() -> None: + from paperforge.worker.ocr_document import compute_layout_facts + + blocks = [ + {"block_id": "b1", "page": 12, "role": "body_paragraph", "zone": "body_zone", "bbox": [70, 100, 540, 160], "text": "Conclusion paragraph."}, + {"block_id": "r1", "page": 12, "role": "reference_item", "zone": "reference_zone", "bbox": [620, 100, 1110, 150], "text": "Brown T. Lancet. 2020;395:10-12."}, + ] + + facts = {row["block_id"]: row for row in compute_layout_facts(blocks)} + assert facts["b1"]["layout_region"] == "body_flow" + assert facts["r1"]["layout_region"] == "reference_candidate" + assert facts["b1"]["reading_band_id"] != facts["r1"]["reading_band_id"] +``` + +- [ ] **Step 6: Re-run the focused tests until green** + +Run: `python -m pytest tests/test_ocr_document.py -k "compute_layout_facts" -v --tb=short` + +Run: `python -m pytest tests/test_ocr_layout_zones.py -k "layout_facts_split_body_and_reference_candidates" -v --tb=short` + +Expected: PASS. + +--- + +### Task 2: Add Reference Family Signals And Journal-Abbreviation Support + +**Files:** +- Create: `paperforge/worker/ocr_reference_signals.py` +- Create: `paperforge/resources/nlm_journal_abbreviations.json` +- Test: `tests/test_ocr_document.py` + +- [ ] **Step 1: Write failing tests for coarse reference-family scoring** + +Append to `tests/test_ocr_document.py`: + +```python +def test_reference_signal_detector_scores_unnumbered_vancouver_entry() -> None: + from paperforge.worker.ocr_reference_signals import score_reference_entry + + result = score_reference_entry( + "Smith J, Doe P. Bone regeneration with scaffold support. J Bone Miner Res. 2021;36(4):100-110. doi:10.1000/test" + ) + + assert result["family"] == "vancouver_structured_unnumbered" + assert result["confidence"] > 0.6 + assert result["signals"]["journal_lexicon_match"] is True + + +def test_reference_signal_detector_distinguishes_report_like_entry() -> None: + from paperforge.worker.ocr_reference_signals import score_reference_entry + + result = score_reference_entry( + "World Health Organization. Clinical management guideline [Internet]. 2023 [cited 2024 Jan 10]. Available from: https://example.org" + ) + + assert result["family"] == "book_or_report" + assert result["signals"]["online_marker_signature"] is True +``` + +- [ ] **Step 2: Run the targeted tests to verify they fail** + +Run: `python -m pytest tests/test_ocr_document.py -k "reference_signal_detector" -v --tb=short` + +Expected: FAIL with module import errors. + +- [ ] **Step 3: Add a compact biomedical journal abbreviation lexicon** + +Create `paperforge/resources/nlm_journal_abbreviations.json` with a small seed set that is enough for unit tests and the first untouched-paper pass: + +```json +[ + {"canonical_title": "The New England Journal of Medicine", "med_abbr": "N Engl J Med", "iso_abbr": "N. Engl. J. Med."}, + {"canonical_title": "The Lancet", "med_abbr": "Lancet", "iso_abbr": "Lancet"}, + {"canonical_title": "Journal of Bone and Mineral Research", "med_abbr": "J Bone Miner Res", "iso_abbr": "J. Bone Miner. Res."}, + {"canonical_title": "British Medical Journal", "med_abbr": "BMJ", "iso_abbr": "BMJ"}, + {"canonical_title": "Nature Reviews Rheumatology", "med_abbr": "Nat Rev Rheumatol", "iso_abbr": "Nat. Rev. Rheumatol."} +] +``` + +- [ ] **Step 4: Implement the minimal reference signal module** + +Create `paperforge/worker/ocr_reference_signals.py`: + +```python +from __future__ import annotations + +import json +import re +from functools import lru_cache +from importlib import resources + + +def _norm(text: str) -> str: + return re.sub(r"\s+", " ", re.sub(r"[^A-Za-z0-9 ]+", " ", text)).strip().lower() + + +@lru_cache(maxsize=1) +def _journal_rows() -> list[dict]: + raw = resources.files("paperforge.resources").joinpath("nlm_journal_abbreviations.json").read_text(encoding="utf-8") + return json.loads(raw) + + +def _has_journal_match(text: str) -> bool: + norm = _norm(text) + for row in _journal_rows(): + for field in ("med_abbr", "iso_abbr", "canonical_title"): + value = _norm(str(row.get(field) or "")) + if value and value in norm: + return True + return False + + +def score_reference_entry(text: str) -> dict: + text = str(text or "").strip() + lower = text.lower() + has_author_signature = bool(re.search(r"\b[A-Z][a-zA-Z'\-]+\s+[A-Z]{1,3}(?:,|\b)", text)) + has_year = bool(re.search(r"\b(19|20)\d{2}\b", text)) + has_vol_pages = bool(re.search(r"\b\d+\s*\(\d+\)\s*:\s*[A-Za-z0-9\-]+", text) or re.search(r"\b\d+\s*:\s*[A-Za-z0-9\-]+", text)) + has_online = any(token in lower for token in ("[internet]", "available from", "doi:", "pmid:", "pmcid:", "published online", "cited ")) + has_report_markers = any(token in lower for token in ("guideline", "organization", "committee", "available from")) or "[internet]" in lower + has_number_lead = bool(re.match(r"^\s*(\[\d+\]|\d+[\.)]?)(\s+|$)", text)) + journal_match = _has_journal_match(text) + + family = "unknown" + confidence = 0.0 + if has_author_signature and has_year and (has_vol_pages or journal_match): + family = "vancouver_structured_numbered" if has_number_lead else "vancouver_structured_unnumbered" + confidence = 0.8 if journal_match else 0.65 + elif has_report_markers and has_year: + family = "book_or_report" + confidence = 0.7 + elif re.search(r"\b[A-Z][a-zA-Z'\-]+\s+[A-Z].*\((19|20)\d{2}\)", text): + family = "author_year" + confidence = 0.6 + return { + "family": family, + "confidence": confidence, + "signals": { + "author_signature": has_author_signature, + "year_signature": has_year, + "volume_issue_pages_signature": has_vol_pages, + "online_marker_signature": has_online, + "journal_lexicon_match": journal_match, + }, + } +``` + +- [ ] **Step 5: Re-run the reference-signal tests until green** + +Run: `python -m pytest tests/test_ocr_document.py -k "reference_signal_detector" -v --tb=short` + +Expected: PASS. + +--- + +### Task 3: Harden Reference Corridor Containment Without Over-Parsing Citations + +**Files:** +- Modify: `paperforge/worker/ocr_document.py` +- Modify: `paperforge/worker/ocr_structural_gate.py` +- Test: `tests/test_ocr_document.py` +- Test: `tests/test_ocr_layout_zones.py` + +- [ ] **Step 1: Write the failing anti-intrusion regression tests** + +Append to `tests/test_ocr_document.py`: + +```python +def test_reference_corridor_keeps_reference_like_blocks_but_rejects_acknowledgements() -> None: + from paperforge.worker.ocr_document import score_reference_corridor_membership + + ref_block = { + "block_id": "r1", + "page": 20, + "role": "reference_item", + "zone": "reference_zone", + "layout_region": "reference_candidate", + "text": "Brown T, Green S. N Engl J Med. 2020;382(4):100-110.", + } + ack_block = { + "block_id": "a1", + "page": 20, + "role": "backmatter_body", + "zone": "tail_nonref_hold_zone", + "layout_region": "tail_candidate", + "text": "Acknowledgements We thank the patients and families.", + } + + ref_score = score_reference_corridor_membership(ref_block) + ack_score = score_reference_corridor_membership(ack_block) + + assert ref_score["accept_reference_membership"] is True + assert ack_score["accept_reference_membership"] is False + assert ack_score["non_ref_intrusion_score"] > ref_score["non_ref_intrusion_score"] + + +def test_reference_hold_does_not_promote_final_reference_membership() -> None: + from paperforge.worker.ocr_structural_gate import build_verified_reference_zone_from_artifacts + + blocks = [ + {"block_id": "x1", "role": "backmatter_body", "zone": "tail_nonref_hold_zone", "text": "Data availability statement."}, + ] + zone = build_verified_reference_zone_from_artifacts(blocks, {"region_bus": {"reference_zone_ids": set()}}) + assert zone.get("status") != "ACCEPT" +``` + +- [ ] **Step 2: Run the corridor tests to verify they fail** + +Run: `python -m pytest tests/test_ocr_document.py -k "reference_corridor_keeps_reference_like_blocks or reference_hold_does_not_promote" -v --tb=short` + +Expected: FAIL with missing function or stale behavior. + +- [ ] **Step 3: Implement practical corridor scoring in `ocr_document.py`** + +Add near reference-zone helpers in `paperforge/worker/ocr_document.py`: + +```python +def score_reference_corridor_membership(block: dict) -> dict: + from paperforge.worker.ocr_reference_signals import score_reference_entry + + text = str(block.get("text") or block.get("block_content") or "").strip() + role = str(block.get("role") or "") + layout_region = str(block.get("layout_region") or "") + style = score_reference_entry(text) + ref_membership_score = 0.0 + if role in {"reference_heading", "reference_item"}: + ref_membership_score += 0.6 + if layout_region == "reference_candidate": + ref_membership_score += 0.2 + ref_membership_score += float(style.get("confidence") or 0.0) * 0.3 + + intrusion = 0.0 + lower = text.lower() + if role.startswith("backmatter"): + intrusion += 0.4 + if any(token in lower for token in ("acknowledgements", "funding", "conflict of interest", "data availability")): + intrusion += 0.8 + if str(block.get("layout_region") or "") in {"body_flow", "display_zone", "side_insert"} and role not in {"reference_heading", "reference_item"}: + intrusion += 0.3 + return { + "ref_membership_score": ref_membership_score, + "non_ref_intrusion_score": intrusion, + "reference_style_family": style["family"], + "reference_style_confidence": style["confidence"], + "accept_reference_membership": ref_membership_score >= 0.55 and intrusion < 0.5, + } +``` + +- [ ] **Step 4: Clamp HOLD so it cannot become accepted reference membership** + +In `paperforge/worker/ocr_structural_gate.py`, after verified-zone construction, ensure candidate-only states stay non-accepted: + +```python + if zone.get("status") == "HOLD": + zone["accepted_block_ids"] = [] + zone["reference_item_count"] = 0 +``` + +If those exact fields do not exist in the current structure, apply the same rule to the nearest accepted-membership fields already present. + +- [ ] **Step 5: Re-run the targeted tests until green** + +Run: `python -m pytest tests/test_ocr_document.py -k "reference_corridor_keeps_reference_like_blocks or reference_hold_does_not_promote" -v --tb=short` + +Expected: PASS. + +--- + +### Task 4: Add Bridge-Aware Display Clusters For Figures + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` +- Test: `tests/test_ocr_figures.py` + +- [ ] **Step 1: Write the failing figure bridge test** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_display_cluster_keeps_empty_bridge_between_asset_and_caption() -> None: + from paperforge.worker.ocr_figures import build_figure_inventory + + structured_blocks = [ + {"page": 9, "block_id": "asset_1", "role": "figure_asset", "bbox": [100, 100, 520, 360], "text": "", "layout_region": "display_zone"}, + {"page": 9, "block_id": "gap_1", "role": "unknown_structural", "bbox": [530, 110, 900, 360], "text": "", "layout_region": "display_zone", "bridge_eligible": True}, + {"page": 9, "block_id": "cap_1", "role": "figure_caption", "bbox": [120, 380, 880, 430], "text": "Figure 2. Multi-panel reconstruction.", "layout_region": "display_zone"}, + ] + + inventory = build_figure_inventory(structured_blocks) + matched = inventory["matched_figures"][0] + assert matched["asset_block_ids"] == ["asset_1"] + assert matched.get("bridge_block_ids") == ["gap_1"] +``` + +- [ ] **Step 2: Run the targeted figure test to verify it fails** + +Run: `python -m pytest tests/test_ocr_figures.py -k "empty_bridge_between_asset_and_caption" -v --tb=short` + +Expected: FAIL because bridge block ids are not carried yet. + +- [ ] **Step 3: Implement bridge-aware candidate collection** + +In `paperforge/worker/ocr_figures.py`, when gathering display candidates, add a helper: + +```python +def _collect_bridge_blocks(structured_blocks: list[dict], page: int) -> list[dict]: + bridges: list[dict] = [] + for block in structured_blocks: + if int(block.get("page", 0) or 0) != page: + continue + if not block.get("bridge_eligible"): + continue + if str(block.get("layout_region") or "") != "display_zone": + continue + bridges.append(block) + return bridges +``` + +Then when a matched figure is emitted, carry any locally relevant bridge ids into the record: + +```python + local_bridges = _collect_bridge_blocks(structured_blocks, caption_page) + bridge_ids = [str(b.get("block_id") or "") for b in local_bridges if b.get("block_id")] + match_record["bridge_block_ids"] = bridge_ids +``` + +- [ ] **Step 4: Re-run the targeted figure test until green** + +Run: `python -m pytest tests/test_ocr_figures.py -k "empty_bridge_between_asset_and_caption" -v --tb=short` + +Expected: PASS. + +--- + +### Task 5: Reuse Bridge-Aware Display Facts For Tables + +**Files:** +- Modify: `paperforge/worker/ocr_tables.py` +- Test: `tests/test_ocr_tables.py` + +- [ ] **Step 1: Write the failing sparse-table bridge test** + +Append to `tests/test_ocr_tables.py`: + +```python +def test_table_inventory_keeps_bridge_gap_inside_sparse_display_cluster() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + {"page": 10, "block_id": "table_asset", "role": "table_asset", "raw_label": "table", "bbox": [100, 120, 620, 420], "text": "", "layout_region": "display_zone"}, + {"page": 10, "block_id": "gap_block", "role": "unknown_structural", "bbox": [640, 130, 930, 420], "text": "", "layout_region": "display_zone", "bridge_eligible": True}, + {"page": 10, "block_id": "table_caption", "role": "table_caption", "bbox": [120, 450, 900, 490], "text": "Table 1. Sparse reconstruction.", "layout_region": "display_zone"}, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + assert table["asset_block_id"] == "table_asset" + assert table.get("bridge_block_ids") == ["gap_block"] +``` + +- [ ] **Step 2: Run the targeted table test to verify it fails** + +Run: `python -m pytest tests/test_ocr_tables.py -k "sparse_display_cluster" -v --tb=short` + +Expected: FAIL because bridge block ids are not emitted. + +- [ ] **Step 3: Emit bridge block ids from table inventory** + +In `paperforge/worker/ocr_tables.py`, when a table asset is matched, add: + +```python + bridge_block_ids = [ + str(block.get("block_id") or "") + for block in structured_blocks + if int(block.get("page", 0) or 0) == int(caption_page or 0) + and block.get("bridge_eligible") + and str(block.get("layout_region") or "") == "display_zone" + and block.get("block_id") + ] +``` + +Then include: + +```python + "bridge_block_ids": bridge_block_ids, +``` + +- [ ] **Step 4: Re-run the targeted table test until green** + +Run: `python -m pytest tests/test_ocr_tables.py -k "sparse_display_cluster" -v --tb=short` + +Expected: PASS. + +--- + +### Task 6: Add Local PDF Text Fallback For Hard Reference Entry Repair + +**Files:** +- Modify: `paperforge/worker/ocr_document.py` +- Test: `tests/test_ocr_pdf_text_fallback.py` + +- [ ] **Step 1: Write the failing local-fallback boundary test** + +Append to `tests/test_ocr_pdf_text_fallback.py`: + +```python +def test_local_reference_pdf_fallback_repairs_only_local_candidate_text() -> None: + from paperforge.worker.ocr_document import repair_reference_entry_from_pdf_text + + block_run = [ + {"block_id": "r1", "page": 14, "bbox": [620, 900, 1100, 950], "text": "Brown T, Green S."}, + {"block_id": "r2", "page": 14, "bbox": [620, 952, 1100, 1000], "text": "N Engl J M"}, + ] + page_text = "Body text ... Brown T, Green S. N Engl J Med. 2020;382(4):100-110. More body text" + + repaired = repair_reference_entry_from_pdf_text(block_run, page_text) + assert "N Engl J Med" in repaired + assert repaired.startswith("Brown T, Green S.") +``` + +- [ ] **Step 2: Run the fallback test to verify it fails** + +Run: `python -m pytest tests/test_ocr_pdf_text_fallback.py -k "local_reference_pdf_fallback" -v --tb=short` + +Expected: FAIL with missing function. + +- [ ] **Step 3: Implement a strict local text-repair helper** + +Add to `paperforge/worker/ocr_document.py`: + +```python +def repair_reference_entry_from_pdf_text(block_run: list[dict], page_text: str) -> str: + seed = " ".join(str(block.get("text") or "").strip() for block in block_run if str(block.get("text") or "").strip()) + seed = re.sub(r"\s+", " ", seed).strip() + if not seed: + return "" + if seed in page_text: + return seed + parts = [part for part in seed.split() if len(part) > 2] + if not parts: + return seed + first = parts[0] + idx = page_text.find(first) + if idx < 0: + return seed + window = page_text[idx: idx + 300] + return window.strip() +``` + +- [ ] **Step 4: Re-run the fallback test until green** + +Run: `python -m pytest tests/test_ocr_pdf_text_fallback.py -k "local_reference_pdf_fallback" -v --tb=short` + +Expected: PASS. + +--- + +### Task 7: Protect Untouched-Paper Behavior And Record The Slice + +**Files:** +- Modify: `tests/test_ocr_real_paper_regressions.py` +- Update: `PROJECT-MANAGEMENT.md` + +- [ ] **Step 1: Add real-paper regressions for the two untouched audit keys** + +Append to `tests/test_ocr_real_paper_regressions.py`: + +```python +def test_kix7skxq_reference_zone_does_not_absorb_acknowledgements(tmp_path: Path) -> None: + result = replay_production_pipeline("KIX7SKXQ", tmp_path) + blocks = result["structured_blocks"] + bad = [ + b for b in blocks + if b.get("zone") == "reference_zone" + and "acknowledgements" in str(b.get("text") or "").lower() + ] + assert bad == [] + + +def test_gtrpmm56_reference_hold_does_not_create_accepted_reference_zone(tmp_path: Path) -> None: + result = replay_production_pipeline("GTRPMM56", tmp_path) + doc = result.get("document_structure") or {} + ref_zone = doc.get("reference_zone") or {} + if ref_zone.get("status") == "HOLD": + assert ref_zone.get("reference_item_count", 0) == 0 +``` + +- [ ] **Step 2: Run the focused untouched-paper regressions** + +Run: `python -m pytest tests/test_ocr_real_paper_regressions.py -k "kix7skxq_reference_zone_does_not_absorb_acknowledgements or gtrpmm56_reference_hold_does_not_create_accepted_reference_zone" -v --tb=short` + +Expected: PASS. + +- [ ] **Step 3: Update `PROJECT-MANAGEMENT.md` with the hardening slice** + +Add a new entry in the usual format. Include: + +```md +### 0.X Reference Zone And Ownership Hardening (2026-06-20) + +Problem: +- untouched truth-audit papers still showed reference intrusion and ownership fragmentation on irregular layouts. + +Root cause: +- page continuity facts were too weakly shared across reference and ownership consumers. + +Fix: +- added shared layout facts, +- hardened practical reference corridor containment, +- introduced journal-abbreviation-backed reference-style support, +- added bridge-aware display continuity for figure/table ownership, +- limited PDF text fallback to local reference-entry repair. + +Result: +- reference handling is more containment-oriented on mixed pages, +- ownership tolerates bridgeable empty gaps without reopening page swallow. + +Test status: +- targeted OCR unit tests and untouched-paper regressions pass. +``` + +- [ ] **Step 4: Run the focused verification bundle** + +Run: `python -m pytest tests/test_ocr_document.py tests/test_ocr_layout_zones.py tests/test_ocr_figures.py tests/test_ocr_tables.py tests/test_ocr_pdf_text_fallback.py tests/test_ocr_real_paper_regressions.py -q` + +Expected: PASS with no new failures in the touched areas. + +--- + +## Self-Review + +### Spec coverage + +- Shared layout-facts layer: covered by Task 1. +- Practical reference corridor containment: covered by Tasks 2-3. +- Journal-abbreviation support: covered by Task 2. +- Local entry reconstruction hook: partially covered by Task 3 and local repair in Task 6. +- Local PDF fallback boundaries: covered by Task 6. +- Cluster-first ownership with bridge-aware continuity: covered by Tasks 4-5. +- Validation on untouched papers: covered by Task 7. + +### Placeholder scan + +- No `TBD`, `TODO`, or deferred implementation placeholders remain in the task steps. +- The only adaptive wording is in Task 3 Step 4 where the exact accepted-membership field name may differ in the current gate structure; the step explicitly constrains the behavior to the nearest existing accepted-membership fields. + +### Type consistency + +- Shared layout field names are consistent across tasks: `reading_band_id`, `display_cluster_candidate_id`, `layout_region`, `boundary_before`, `boundary_after`, `bridge_eligible`. +- Reference scoring contract names are consistent across tasks: `ref_membership_score`, `non_ref_intrusion_score`, `reference_style_family`, `reference_style_confidence`. +- Ownership bridge contract name is consistent across tasks: `bridge_block_ids`. diff --git a/docs/superpowers/plans/2026-06-20-region-growing-figure-merge-implementation.md b/docs/superpowers/plans/2026-06-20-region-growing-figure-merge-implementation.md new file mode 100644 index 00000000..635ac892 --- /dev/null +++ b/docs/superpowers/plans/2026-06-20-region-growing-figure-merge-implementation.md @@ -0,0 +1,382 @@ +# Region-Growing Figure Merge Implementation Plan + +> **For agentic workers:** REQUIRED SUB-SKILL: Use superpowers:subagent-driven-development (recommended) or superpowers:executing-plans to implement this plan task-by-task. Steps use checkbox (`- [ ]`) syntax for tracking. + +**Goal:** Replace fragile row-first figure grouping with seed-based region growth plus validation, without reintroducing page-swallow behavior. + +**Architecture:** Keep the current safe `page_assets` guardrails and add a separate candidate-group growth model: seed from the earliest plausible asset, grow by local adjacency, record merge evidence, then validate the grown group before strict ownership. If validation fails, demote or split instead of forcing a match. + +**Tech Stack:** Python 3.14, `paperforge.worker.ocr_figures`, pytest, existing real-paper regressions, rebuild verification on residual and unseen figure-heavy papers. + +--- + +## File Structure + +- Modify: `paperforge/worker/ocr_figures.py` + - Owns seed selection, local adjacency growth, candidate-group evidence, and post-growth validation. +- Modify: `tests/test_ocr_figures.py` + - Unit coverage for region growth and false-merge rejection. +- Modify: `tests/test_ocr_real_paper_regressions.py` + - Real-paper protection against page swallow and irregular-layout regressions. +- Modify: `PROJECT-MANAGEMENT.md` + - Record the completed figure-merge slice and remaining ownership residuals. + +--- + +### Task 1: Add Region-Growth Candidate Data Structures + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` +- Modify: `tests/test_ocr_figures.py` + +- [ ] **Step 1: Add a failing test for local right-neighbor growth** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_region_growth_absorbs_adjacent_right_neighbor() -> None: + from paperforge.worker.ocr_figures import _grow_region_from_seed + + seed = {"block_id": "a1", "bbox": [100, 100, 300, 260], "page": 5} + others = [ + {"block_id": "a2", "bbox": [315, 105, 520, 258], "page": 5}, + {"block_id": "a3", "bbox": [700, 100, 920, 260], "page": 5}, + ] + + group = _grow_region_from_seed(seed, others, page_width=1000) + + assert group["asset_block_ids"] == ["a1", "a2"] + assert any(step["reason"] == "adjacent_right" for step in group["growth_steps"]) +``` + +- [ ] **Step 2: Add a failing test for stacked growth** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_region_growth_absorbs_adjacent_below_neighbor() -> None: + from paperforge.worker.ocr_figures import _grow_region_from_seed + + seed = {"block_id": "a1", "bbox": [100, 100, 320, 250], "page": 6} + others = [ + {"block_id": "a2", "bbox": [98, 265, 325, 420], "page": 6}, + ] + + group = _grow_region_from_seed(seed, others, page_width=1000) + + assert group["asset_block_ids"] == ["a1", "a2"] + assert any(step["reason"] == "adjacent_below" for step in group["growth_steps"]) +``` + +- [ ] **Step 3: Run the red tests** + +Run: `python -m pytest tests/test_ocr_figures.py -k "region_growth_absorbs" -v` + +Expected: FAIL because region-growing helpers do not exist yet. + +- [ ] **Step 4: Implement seed-based growth helpers in `ocr_figures.py`** + +Add helper functions: + +```python +def _asset_gap_right(a: dict, b: dict) -> float: + ab = a.get("bbox") or [0, 0, 0, 0] + bb = b.get("bbox") or [0, 0, 0, 0] + return max(0.0, bb[0] - ab[2]) + + +def _asset_gap_below(a: dict, b: dict) -> float: + ab = a.get("bbox") or [0, 0, 0, 0] + bb = b.get("bbox") or [0, 0, 0, 0] + return max(0.0, bb[1] - ab[3]) + + +def _grow_region_from_seed(seed: dict, others: list[dict], page_width: float) -> dict: + group = [seed] + growth_steps: list[dict] = [] + remaining = list(others) + changed = True + while changed: + changed = False + group_bbox = _cluster_bbox([g.get("bbox", [0, 0, 0, 0]) for g in group]) + next_remaining = [] + for candidate in remaining: + reason = None + cb = candidate.get("bbox") or [0, 0, 0, 0] + if cb[0] >= group_bbox[2] and _asset_gap_right({"bbox": group_bbox}, candidate) <= page_width * 0.03: + reason = "adjacent_right" + elif cb[1] >= group_bbox[3] and _asset_gap_below({"bbox": group_bbox}, candidate) <= page_width * 0.03: + reason = "adjacent_below" + if reason: + group.append(candidate) + growth_steps.append({"added_block_id": candidate.get("block_id", ""), "reason": reason}) + changed = True + else: + next_remaining.append(candidate) + remaining = next_remaining + return { + "seed_asset_block_id": seed.get("block_id", ""), + "asset_block_ids": [g.get("block_id", "") for g in group if g.get("block_id")], + "growth_steps": growth_steps, + "group_bbox": _cluster_bbox([g.get("bbox", [0, 0, 0, 0]) for g in group]), + } +``` + +- [ ] **Step 5: Re-run the targeted tests** + +Run: `python -m pytest tests/test_ocr_figures.py -k "region_growth_absorbs" -v` + +Expected: PASS. + +- [ ] **Step 6: Commit** + +```bash +git add paperforge/worker/ocr_figures.py tests/test_ocr_figures.py +git commit -m "feat: add seed-based region growth for figure groups" +``` + +--- + +### Task 2: Add Validation And False-Merge Rejection + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` +- Modify: `tests/test_ocr_figures.py` + +- [ ] **Step 1: Add a failing test for suspicious large-gap merge rejection** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_region_growth_validation_rejects_large_gap_without_support() -> None: + from paperforge.worker.ocr_figures import _validate_grown_region + + group = { + "asset_block_ids": ["a1", "a2"], + "group_bbox": [100, 100, 800, 260], + "growth_steps": [{"added_block_id": "a2", "reason": "adjacent_right"}], + } + assets = [ + {"block_id": "a1", "bbox": [100, 100, 260, 260], "page": 5}, + {"block_id": "a2", "bbox": [620, 100, 800, 260], "page": 5}, + ] + + verdict = _validate_grown_region(group, assets) + assert verdict["validation_status"] == "split_required" +``` + +- [ ] **Step 2: Add a failing test for grouped-evidence demotion when another caption control zone is crossed** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_region_growth_validation_demotes_group_when_crossing_other_caption_zone() -> None: + from paperforge.worker.ocr_figures import _validate_grown_region + + group = { + "asset_block_ids": ["a1", "a2"], + "group_bbox": [100, 100, 520, 260], + "growth_steps": [{"added_block_id": "a2", "reason": "adjacent_right"}], + } + assets = [ + {"block_id": "a1", "bbox": [100, 100, 300, 260], "page": 5}, + {"block_id": "a2", "bbox": [320, 100, 520, 260], "page": 5}, + ] + other_caption_bbox = [340, 270, 520, 300] + + verdict = _validate_grown_region(group, assets, competing_caption_bboxes=[other_caption_bbox]) + assert verdict["validation_status"] == "grouped_evidence_only" +``` + +- [ ] **Step 3: Run the red tests** + +Run: `python -m pytest tests/test_ocr_figures.py -k "validation_rejects_large_gap or validation_demotes_group" -v` + +Expected: FAIL because validation helpers do not exist yet. + +- [ ] **Step 4: Implement post-growth validation helpers** + +Add: + +```python +def _validate_grown_region(group: dict, assets: list[dict], competing_caption_bboxes: list[list[float]] | None = None) -> dict: + competing_caption_bboxes = competing_caption_bboxes or [] + asset_map = {str(a.get("block_id", "")): a for a in assets} + group_assets = [asset_map[bid] for bid in group.get("asset_block_ids", []) if bid in asset_map] + if len(group_assets) <= 1: + return {"validation_status": "strict_match_ok", "validation_reason": "single_asset"} + + ordered = sorted(group_assets, key=lambda a: (a.get("bbox") or [0, 0, 0, 0])[0]) + max_gap = 0.0 + for left, right in zip(ordered, ordered[1:], strict=False): + lb = left.get("bbox") or [0, 0, 0, 0] + rb = right.get("bbox") or [0, 0, 0, 0] + max_gap = max(max_gap, max(0.0, rb[0] - lb[2])) + if max_gap > 250.0: + return {"validation_status": "split_required", "validation_reason": "gap_too_large"} + + gb = group.get("group_bbox") or [0, 0, 0, 0] + for cb in competing_caption_bboxes: + if len(gb) >= 4 and len(cb) >= 4 and cb[0] < gb[2] and gb[0] < cb[2]: + return {"validation_status": "grouped_evidence_only", "validation_reason": "crosses_competing_caption_zone"} + + return {"validation_status": "strict_match_ok", "validation_reason": "local_growth_validated"} +``` + +- [ ] **Step 5: Re-run the targeted tests** + +Run: `python -m pytest tests/test_ocr_figures.py -k "validation_rejects_large_gap or validation_demotes_group" -v` + +Expected: PASS. + +- [ ] **Step 6: Commit** + +```bash +git add paperforge/worker/ocr_figures.py tests/test_ocr_figures.py +git commit -m "fix: validate grown figure groups before strict ownership" +``` + +--- + +### Task 3: Integrate Region Growth Into Candidate Group Construction + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` +- Modify: `tests/test_ocr_figures.py` + +- [ ] **Step 1: Add a failing integration test for region-grown groups reaching the inventory surface** + +Append to `tests/test_ocr_figures.py`: + +```python +def test_build_figure_inventory_uses_region_grown_group_for_irregular_pair() -> None: + from paperforge.worker.ocr_figures import build_figure_inventory + + structured_blocks = [ + {"page": 5, "block_id": "a1", "role": "figure_asset", "raw_label": "image", "bbox": [100, 100, 300, 260], "text": ""}, + {"page": 5, "block_id": "a2", "role": "figure_asset", "raw_label": "image", "bbox": [315, 110, 525, 270], "text": ""}, + {"page": 5, "block_id": "c1", "role": "figure_caption", "text": "Figure 1. Irregular pair.", "bbox": [100, 290, 520, 330], "zone": "display_zone", "style_family": "legend_like"}, + ] + + inventory = build_figure_inventory(structured_blocks) + match = inventory["matched_figures"][0] + assert len(match["matched_assets"]) == 2 +``` + +- [ ] **Step 2: Run the red test** + +Run: `python -m pytest tests/test_ocr_figures.py -k "region_grown_group_for_irregular_pair" -v` + +Expected: FAIL until growth candidates are integrated into inventory construction. + +- [ ] **Step 3: Integrate region growth into `_build_candidate_figure_groups_from_assets`** + +After single-asset group creation, add a region-growth pass per page: + +```python + for page, page_media in by_page.items(): + ... + sorted_page_media = sorted(page_media, key=lambda b: ((b.get("bbox") or [0, 0, 0, 0])[1], (b.get("bbox") or [0, 0, 0, 0])[0])) + seen_growth_ids: set[str] = set() + for seed in sorted_page_media: + seed_id = str(seed.get("block_id", "")) + if seed_id in seen_growth_ids: + continue + grown = _grow_region_from_seed(seed, [b for b in sorted_page_media if b is not seed], page_width) + if len(grown.get("asset_block_ids", [])) <= 1: + continue + seen_growth_ids.update(grown.get("asset_block_ids", [])) + entry = _candidate_group_entry( + f"group_{next_id:03d}", + page, + [b for b in sorted_page_media if str(b.get("block_id", "")) in set(grown.get("asset_block_ids", []))], + "region_grown_group", + ["same_page", "region_growth"], + ) + entry["growth_steps"] = grown.get("growth_steps", []) + groups.append(entry) + next_id += 1 +``` + +- [ ] **Step 4: Re-run the targeted test** + +Run: `python -m pytest tests/test_ocr_figures.py -k "region_grown_group_for_irregular_pair" -v` + +Expected: PASS. + +- [ ] **Step 5: Run the full figure suite and page-swallow regression** + +Run: + +```bash +python -m pytest tests/test_ocr_figures.py -v --tb=short +python -m pytest tests/test_ocr_real_paper_regressions.py -k "mega_merges_same_page_assets" -v +``` + +Expected: PASS. + +- [ ] **Step 6: Commit** + +```bash +git add paperforge/worker/ocr_figures.py tests/test_ocr_figures.py tests/test_ocr_real_paper_regressions.py +git commit -m "feat: integrate region-grown figure groups into inventory" +``` + +--- + +### Task 4: Validate On Residual And Unseen Figure-Heavy Papers, Then Record The Slice + +**Files:** +- Modify: `PROJECT-MANAGEMENT.md` + +- [ ] **Step 1: Rebuild a figure-heavy validation sample after the merge changes** + +Run: + +```bash +python -m paperforge --vault "D:\L\OB\Literature-hub" ocr rebuild --clear-checkpoint +python -m paperforge --vault "D:\L\OB\Literature-hub" ocr rebuild A8E7SRVS SAN9AYVR 4PFR9M5N 7I4YGKFG DWQQK2YB VZMMSJBS X3NTXX4M +``` + +Expected: rebuild completes without reviving page-swallow behavior. + +- [ ] **Step 2: Verify residual metrics and no new failure family** + +Check generated artifacts for: + +- improved grouped asset recall on irregular layouts, +- no return of unrestricted `page_assets` behavior, +- no blockquote or truth-surface regressions introduced indirectly, +- no new failure family on unseen papers. + +- [ ] **Step 3: Update `PROJECT-MANAGEMENT.md`** + +Append: + +```md +### 11.5 Region-Growing Figure Merge Slice (2026-06-20) + +**Problem:** Row-first pair/triple grouping had become safe after `page_assets` gating, but still under-modeled irregular multi-panel figures and left figure ownership recall on the table. + +**Root cause:** Candidate groups were still built around neat-layout assumptions and lacked a seed-growth model plus post-growth validation. + +**Fix:** Added seed-based local region growth, retained merge evidence per absorbed asset, validated grown groups before strict ownership, and demoted or split suspicious merges rather than forcing them. + +**Result:** Figure grouping is less dependent on tidy layouts while preserving the no-page-swallow guardrail. + +**Validation:** Rebuilt residual and unseen figure-heavy papers after the change; no new failure family introduced. +``` + +- [ ] **Step 4: Commit** + +```bash +git add PROJECT-MANAGEMENT.md +git commit -m "docs: record region-growing figure merge slice" +``` + +--- + +## Self-Review Notes + +- Spec coverage: this plan covers seed selection, local adjacency growth, merge evidence, post-growth validation, integration into inventory, and residual/unseen-paper validation. +- Scope discipline: table-note and table ambiguity work remains in the separate design thread. diff --git a/docs/superpowers/plans/2026-06-20-table-note-stabilization-implementation.md b/docs/superpowers/plans/2026-06-20-table-note-stabilization-implementation.md new file mode 100644 index 00000000..4ecdc8ea --- /dev/null +++ b/docs/superpowers/plans/2026-06-20-table-note-stabilization-implementation.md @@ -0,0 +1,475 @@ +# Table Note Stabilization Implementation Plan + +> **For agentic workers:** REQUIRED SUB-SKILL: Use superpowers:subagent-driven-development (recommended) or superpowers:executing-plans to implement this plan task-by-task. Steps use checkbox (`- [ ]`) syntax for tracking. + +**Goal:** Stabilize table-note ownership with page-footnote priors and note-band grouping, while improving bare `Table N` ambiguity resolution through stronger spatial tie-breaks. + +**Architecture:** Keep OCR role classification unchanged and harden only the post-ownership table surface. The implementation adds a page-level footnote prior, groups note candidates into a local note band below matched tables, strengthens body exclusion, and upgrades bare `Table N` decisions through layout tie-breaks rather than freer caption admission. + +**Tech Stack:** Python 3.14, `paperforge.worker.ocr_tables`, `ocr_objects`, `ocr_render`, `ocr_health`, pytest, rebuild verification on known residual and unseen papers. + +--- + +## File Structure + +- Modify: `paperforge/worker/ocr_tables.py` + - Owns page-footnote prior, note-band grouping, note ownership output, and table ambiguity tie-breaks. +- Modify: `paperforge/worker/ocr_objects.py` + - Owns projection of note-band metadata into table object markdown. +- Modify: `paperforge/worker/ocr_render.py` + - Owns body-flow suppression for consumed table-note bands. +- Modify: `paperforge/worker/ocr_health.py` + - Owns additive reporting only if table-note / ambiguity fields need audit surfacing. +- Modify: `tests/test_ocr_tables.py` + - Primary unit coverage for page-footnote prior, note-band grouping, and bare `Table N` tie-breaks. +- Modify: `tests/test_ocr_objects.py` + - Table object markdown note-band rendering coverage. +- Modify: `tests/test_ocr_rendering.py` + - Consumed note-band suppression coverage. +- Modify: `PROJECT-MANAGEMENT.md` + - Record the completed table-note stabilization slice and remaining hard cases. + +--- + +### Task 1: Add Page-Footnote Prior And Note-Band Data Model + +**Files:** +- Modify: `paperforge/worker/ocr_tables.py` +- Modify: `tests/test_ocr_tables.py` + +- [ ] **Step 1: Add a failing test for page-footnote prior outranking table-note attachment at page bottom** + +Append this test to `tests/test_ocr_tables.py`: + +```python +def test_page_footnote_prior_prevents_table_at_page_bottom_from_absorbing_footer_note() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + {"page": 4, "block_id": "p4_a1", "role": "table_asset", "raw_label": "table", "bbox": [80, 980, 760, 1280], "text": ""}, + {"page": 4, "block_id": "p4_c1", "role": "table_caption", "text": "Table 2. Results", "bbox": [80, 1295, 760, 1330]}, + {"page": 4, "block_id": "p4_fn1", "role": "footnote", "raw_label": "vision_footnote", "text": "* Correspondence footnote", "bbox": [80, 1365, 760, 1390]}, + {"page": 2, "block_id": "p2_fn1", "role": "footnote", "raw_label": "vision_footnote", "text": "* prior footer", "bbox": [70, 1360, 750, 1388]}, + {"page": 3, "block_id": "p3_fn1", "role": "footnote", "raw_label": "vision_footnote", "text": "* prior footer", "bbox": [72, 1362, 748, 1389]}, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + + assert table["note_block_ids"] == [] + assert table["note_match_reason"] == "page_footnote_prior_rejected" +``` + +- [ ] **Step 2: Add a failing test for multi-line note-band grouping below a matched table** + +Append this test to `tests/test_ocr_tables.py`: + +```python +def test_table_note_blocks_group_into_single_note_band() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + {"page": 5, "block_id": "p5_a1", "role": "table_asset", "raw_label": "table", "bbox": [100, 100, 640, 430], "text": ""}, + {"page": 5, "block_id": "p5_c1", "role": "table_caption", "text": "Table 1. Main results", "bbox": [100, 445, 640, 475]}, + {"page": 5, "block_id": "p5_n1", "role": "footnote", "raw_label": "vision_footnote", "text": "* p < 0.05", "bbox": [110, 440, 520, 458]}, + {"page": 5, "block_id": "p5_n2", "role": "footnote", "raw_label": "vision_footnote", "text": "Data are mean ± SD.", "bbox": [110, 460, 560, 480]}, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + + assert table["note_block_ids"] == ["p5_n1", "p5_n2"] + assert table["note_band_bbox"] == [110, 440, 560, 480] + assert table["note_match_reason"] == "note_band_geometry_match" +``` + +- [ ] **Step 3: Run the red tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "page_footnote_prior_prevents or note_band" -v` + +Expected: FAIL because the current inventory does not compute a page-footnote prior or note-band bbox/reason. + +- [ ] **Step 4: Implement page-footnote prior helpers in `ocr_tables.py`** + +Add helpers near the top of `paperforge/worker/ocr_tables.py`: + +```python +def _collect_page_footnote_prior(structured_blocks: list[dict]) -> dict[int, float]: + prior_by_page: dict[int, float] = {} + footer_tops: list[float] = [] + for block in structured_blocks: + if str(block.get("role", "") or "") != "footnote" and str(block.get("raw_label", "") or "") != "vision_footnote": + continue + bbox = block.get("bbox") or [0, 0, 0, 0] + if len(bbox) < 4: + continue + footer_tops.append(float(bbox[1])) + if not footer_tops: + return prior_by_page + typical_top = min(footer_tops) + for block in structured_blocks: + page = int(block.get("page", 0) or 0) + if page: + prior_by_page[page] = typical_top + return prior_by_page + + +def _table_note_falls_into_page_footnote_prior(note_bbox: list[float], page: int, prior_by_page: dict[int, float]) -> bool: + if page not in prior_by_page or len(note_bbox) < 4: + return False + return float(note_bbox[1]) >= float(prior_by_page[page]) +``` + +- [ ] **Step 5: Implement note-band grouping and new note contract fields** + +Replace the single-block note collection path in `build_table_inventory()` with grouped note-band logic: + +```python + note_block_ids: list[str] = [] + note_texts: list[str] = [] + note_bboxes: list[list[float]] = [] + note_band_bbox: list[float] = [] + note_match_reason = "" + note_confidence = 0.0 + + page_footnote_prior = _collect_page_footnote_prior(structured_blocks) + + if matched_asset: + asset_page = matched_asset.get("page", 0) + asset_bbox = matched_asset.get("bbox", [0, 0, 0, 0]) + asset_bottom = asset_bbox[3] if len(asset_bbox) >= 4 else 0 + candidates: list[dict] = [] + for block in structured_blocks: + if int(block.get("page", 0) or 0) != int(asset_page or 0): + continue + bbbox = block.get("bbox") or [0, 0, 0, 0] + if len(bbbox) < 4: + continue + if bbbox[1] < asset_bottom or bbbox[1] > asset_bottom + 100: + continue + if _table_note_falls_into_page_footnote_prior(bbbox, int(asset_page or 0), page_footnote_prior): + note_match_reason = "page_footnote_prior_rejected" + continue + candidates.append(block) + + if candidates: + candidates.sort(key=lambda b: (b.get("bbox") or [0, 0, 0, 0])[1]) + note_block_ids = [str(b.get("block_id", "")) for b in candidates if b.get("block_id")] + note_texts = [str(b.get("text", "") or "").strip() for b in candidates if str(b.get("text", "") or "").strip()] + note_bboxes = [b.get("bbox", [0, 0, 0, 0]) for b in candidates] + note_band_bbox = [ + min(bb[0] for bb in note_bboxes), + min(bb[1] for bb in note_bboxes), + max(bb[2] for bb in note_bboxes), + max(bb[3] for bb in note_bboxes), + ] + note_match_reason = "note_band_geometry_match" + note_confidence = 0.85 +``` + +Then emit: + +```python + "note_bboxes": note_bboxes, + "note_band_bbox": note_band_bbox, + "note_match_reason": note_match_reason, + "note_confidence": note_confidence, +``` + +- [ ] **Step 6: Re-run the targeted tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "page_footnote_prior_prevents or note_band" -v` + +Expected: PASS. + +- [ ] **Step 7: Commit** + +```bash +git add paperforge/worker/ocr_tables.py tests/test_ocr_tables.py +git commit -m "feat: add page footnote prior for table note bands" +``` + +--- + +### Task 2: Add Body Exclusion And Object/Render Projection For Note Bands + +**Files:** +- Modify: `paperforge/worker/ocr_tables.py` +- Modify: `paperforge/worker/ocr_objects.py` +- Modify: `paperforge/worker/ocr_render.py` +- Modify: `tests/test_ocr_objects.py` +- Modify: `tests/test_ocr_rendering.py` + +- [ ] **Step 1: Add a failing object markdown test for note-band metadata** + +Append to `tests/test_ocr_objects.py`: + +```python +def test_table_object_markdown_renders_note_band_texts_in_notes_section() -> None: + from paperforge.worker.ocr_objects import render_table_object_markdown + + md = render_table_object_markdown( + { + "table_id": "table_001", + "page": 5, + "caption": "Table 1. Results.", + "image_relpath": "assets/tables/table_001.jpg", + "note_texts": ["* p < 0.05", "Data are mean ± SD."], + "note_match_reason": "note_band_geometry_match", + } + ) + + assert "## Notes" in md + assert "* p < 0.05" in md + assert "Data are mean ± SD." in md +``` + +- [ ] **Step 2: Add a failing render test that consumed note-band blocks do not fall back into body flow** + +Append to `tests/test_ocr_rendering.py`: + +```python +def test_fulltext_skips_consumed_table_note_band_blocks() -> None: + from paperforge.worker.ocr_render import render_fulltext_markdown + + structured_blocks = [ + {"page": 5, "block_id": "p5_c1", "role": "table_caption", "text": "Table 1. Main results", "bbox": [100, 430, 600, 460], "zone": "display_zone", "style_family": "table_caption_like"}, + {"page": 5, "block_id": "p5_n1", "role": "footnote", "text": "* p < 0.05", "bbox": [100, 470, 600, 490]}, + {"page": 5, "block_id": "p5_n2", "role": "footnote", "text": "Data are mean ± SD.", "bbox": [100, 492, 600, 512]}, + ] + table_inventory = { + "tables": [ + { + "table_id": "table_001", + "page": 5, + "caption_block_id": "p5_c1", + "asset_block_id": "p5_a1", + "note_block_ids": ["p5_n1", "p5_n2"], + "consumed_block_ids": ["p5_c1", "p5_a1", "p5_n1", "p5_n2"], + } + ] + } + + md = render_fulltext_markdown( + structured_blocks=structured_blocks, + resolved_metadata={}, + figure_inventory={"matched_figures": []}, + table_inventory=table_inventory, + page_count=5, + document_structure=None, + reader_payload={"figures": []}, + ) + + assert "* p < 0.05" not in md + assert "Data are mean ± SD." not in md +``` + +- [ ] **Step 3: Run the red tests** + +Run: `python -m pytest tests/test_ocr_objects.py -k "note_band" tests/test_ocr_rendering.py -k "note_band_blocks" -v` + +Expected: FAIL if note-band projection is incomplete. + +- [ ] **Step 4: Strengthen body exclusion in `ocr_tables.py`** + +Before finalizing a note band, reject candidates that look too much like body flow: + +```python +def _looks_like_body_text_below_table(block: dict, table_bbox: list[float]) -> bool: + bbox = block.get("bbox") or [0, 0, 0, 0] + if len(bbox) < 4 or len(table_bbox) < 4: + return False + block_width = bbox[2] - bbox[0] + table_width = table_bbox[2] - table_bbox[0] + text = str(block.get("text", "") or "").strip() + return block_width >= table_width * 0.9 and len(text.split()) >= 12 +``` + +Use it to exclude likely body blocks from the note band. + +- [ ] **Step 5: Keep object/render projection aligned with the note-band contract** + +Ensure: + +```python +# ocr_objects.py +note_texts = [normalize_ocr_math_text(t) for t in table.get("note_texts", []) if t] + +# ocr_render.py +consumed_table_block_ids.update(table.get("consumed_block_ids", [])) +``` + +No new semantic classification should be added in render. + +- [ ] **Step 6: Re-run the targeted tests** + +Run: `python -m pytest tests/test_ocr_objects.py -k "note_band" tests/test_ocr_rendering.py -k "note_band_blocks" -v` + +Expected: PASS. + +- [ ] **Step 7: Commit** + +```bash +git add paperforge/worker/ocr_tables.py paperforge/worker/ocr_objects.py paperforge/worker/ocr_render.py tests/test_ocr_objects.py tests/test_ocr_rendering.py +git commit -m "fix: project table note bands through object and render" +``` + +--- + +### Task 3: Continue Bare `Table N` Stabilization With Stronger Tie-Breaks + +**Files:** +- Modify: `paperforge/worker/ocr_tables.py` +- Modify: `tests/test_ocr_tables.py` + +- [ ] **Step 1: Add a failing same-page tie-break test** + +Append to `tests/test_ocr_tables.py`: + +```python +def test_bare_table_number_prefers_candidate_with_better_x_overlap_and_shorter_vertical_gap() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + {"page": 6, "block_id": "p6_a1", "role": "table_asset", "raw_label": "table", "bbox": [100, 200, 600, 500], "text": ""}, + {"page": 6, "block_id": "p6_a2", "role": "table_asset", "raw_label": "table", "bbox": [620, 120, 980, 520], "text": ""}, + {"page": 6, "block_id": "p6_c1", "role": "table_caption", "text": "Table 3", "bbox": [100, 520, 600, 545]}, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + + assert table["asset_block_id"] == "p6_a1" + assert table["match_status"] in {"matched", "matched_low_confidence"} +``` + +- [ ] **Step 2: Add a failing continuation-page test** + +Append to `tests/test_ocr_tables.py`: + +```python +def test_bare_table_number_can_match_previous_page_continuation_under_strong_geometry() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + {"page": 7, "block_id": "p7_a1", "role": "table_asset", "raw_label": "table", "bbox": [100, 120, 640, 1000], "text": ""}, + {"page": 8, "block_id": "p8_c1", "role": "table_caption", "text": "Table 4", "bbox": [100, 90, 640, 120]}, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + + assert table["match_status"] in {"matched_low_confidence", "matched"} + assert table["asset_block_id"] == "p7_a1" +``` + +- [ ] **Step 3: Run the red tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "prefers_candidate_with_better_x_overlap or continuation_under_strong_geometry" -v` + +Expected: FAIL because the current same-page tie-break is not strong enough and continuation handling is too conservative. + +- [ ] **Step 4: Improve tie-break scoring in `ocr_tables.py`** + +Add a helper to rank bare-table candidates after the base scorer runs: + +```python +def _bare_table_tie_break(score: dict, caption: dict, asset: dict) -> tuple[float, float, float]: + cb = caption.get("bbox") or [0, 0, 0, 0] + ab = asset.get("bbox") or [0, 0, 0, 0] + x_overlap = min(cb[2], ab[2]) - max(cb[0], ab[0]) if len(cb) >= 4 and len(ab) >= 4 else 0.0 + vertical_gap = max(0.0, cb[1] - ab[3]) if len(cb) >= 4 and len(ab) >= 4 else 9999.0 + return (float(score.get("score", 0.0)), float(x_overlap), -float(vertical_gap)) +``` + +Use this tuple as a secondary sort key for weak explicit captions after `score_table_match` runs. + +- [ ] **Step 5: Allow a continuation-specific geometry path for bare `Table N`** + +If a candidate asset is on the previous page and: + +- x overlap is high, +- the asset extends near the previous page bottom, +- the caption sits at the next page top, + +allow `matched_low_confidence` rather than forcing `ambiguous`. + +Keep this path narrower than same-page matching. + +- [ ] **Step 6: Re-run the targeted tests** + +Run: `python -m pytest tests/test_ocr_tables.py -k "prefers_candidate_with_better_x_overlap or continuation_under_strong_geometry" -v` + +Expected: PASS. + +- [ ] **Step 7: Run the full table suite** + +Run: `python -m pytest tests/test_ocr_tables.py -v --tb=short` + +Expected: PASS. + +- [ ] **Step 8: Commit** + +```bash +git add paperforge/worker/ocr_tables.py tests/test_ocr_tables.py +git commit -m "fix: improve bare table ambiguity tie-breaks" +``` + +--- + +### Task 4: Validate On Residual And Unseen Papers, Then Record The Slice + +**Files:** +- Modify: `PROJECT-MANAGEMENT.md` + +- [ ] **Step 1: Rebuild a residual sample set after the table-note changes** + +Run: + +```bash +python -m paperforge --vault "D:\L\OB\Literature-hub" ocr rebuild --clear-checkpoint +python -m paperforge --vault "D:\L\OB\Literature-hub" ocr rebuild 69TA9S8W 4PFR9M5N 7I4YGKFG A8E7SRVS X5FJTVGP VZMMSJBS X3NTXX4M +``` + +Expected: rebuild completes without introducing a new failure family. + +- [ ] **Step 2: Verify table-note and ambiguity metrics from generated artifacts** + +Check these artifact expectations manually or with a small script: + +- no blockquote table captions in fulltext, +- note-band fields present where note ownership exists, +- some previously ambiguous bare `Table N` cases now become `matched_low_confidence` or `matched`, +- page-bottom footer notes are not greedily absorbed. + +- [ ] **Step 3: Update `PROJECT-MANAGEMENT.md` with the completed slice** + +Append a new section: + +```md +### 11.4 Table Note Stabilization + Table Ambiguity Slice (2026-06-20) + +**Problem:** Table notes still risked confusion with page footnotes and body text, while bare `Table N` captions still stayed overly ambiguous after the first rebuild-hardening pass. + +**Root cause:** The table surface lacked a page-footnote prior, grouped note-band ownership, and stronger layout tie-breaks among already-accepted table candidates. + +**Fix:** Added page-footnote priors, table-below note-band grouping, body exclusion, explicit note-band contract fields, and stronger same-page / continuation tie-breaks for bare `Table N`. + +**Result:** Table-note ownership is more stable, page-bottom footer notes are less likely to be absorbed, and table ambiguity is reduced through geometry rather than freer caption admission. + +**Validation:** Rebuilt residual and unseen papers after the change; no new failure family introduced. +``` + +- [ ] **Step 4: Commit** + +```bash +git add PROJECT-MANAGEMENT.md +git commit -m "docs: record table note stabilization slice" +``` + +--- + +## Self-Review Notes + +- Spec coverage: this plan covers page-footnote priors, note-band grouping, body exclusion, stronger bare `Table N` tie-breaks, and residual/unseen-paper validation. +- Scope discipline: figure ownership and merge growth are explicitly deferred to the second design thread. diff --git a/docs/superpowers/plans/2026-06-21-global-distance-clustering-figure-merge-implementation.md b/docs/superpowers/plans/2026-06-21-global-distance-clustering-figure-merge-implementation.md new file mode 100644 index 00000000..b9d8964a --- /dev/null +++ b/docs/superpowers/plans/2026-06-21-global-distance-clustering-figure-merge-implementation.md @@ -0,0 +1,873 @@ +# Global Distance Clustering Figure Merge — Implementation Plan + +> **For agentic workers:** REQUIRED SUB-SKILL: Use superpowers:subagent-driven-development or superpowers:executing-plans to implement task-by-task. Steps use checkbox syntax. + +**Goal:** Replace greedy region-growing figure merge with global pairwise distance clustering + caption band partition + group-aware fallback. + +**Architecture:** Three new functions (`_filter_figure_assets`, `_cluster_page_assets`, `_has_text_separator`) replace `_grow_region_from_seed` + `_validate_grown_region` + gap helpers. `_build_candidate_figure_groups_from_assets` rewritten to produce one group per asset. `_score_legend_to_group` gets `distance_cluster` branch. Sequential fallback becomes group-aware. + +**Tech Stack:** Python 3.12+ (same as paperforge), union-find (stdlib only), no new dependencies. + +**Spec:** `docs/superpowers/specs/2026-06-21-global-distance-clustering-figure-merge.md` + +--- + +## File Structure + +| File | Responsibility | +|------|---------------| +| `paperforge/worker/ocr_figures.py` | All figure inventory logic: asset filtering, clustering, scoring, fallback | +| `tests/test_ocr_figures.py` | Unit tests for clustering, text separator, scoring | +| `tests/test_ocr_real_paper_regressions.py` | Production replay tests for regression check | + +### Functions in scope + +| Function | Action | +|----------|--------| +| `_build_candidate_figure_groups_from_assets` | REWRITE: replace body with clustering | +| `_grow_region_from_seed` | DELETE | +| `_validate_grown_region` | DELETE | +| `_asset_gap_left` | DELETE | +| `_asset_gap_above` | DELETE | +| `_media_clusters` | KEEP (used elsewhere, don't touch) | +| `_candidate_group_entry` | KEEP | +| `_cluster_bbox` | KEEP | +| `_expand_matched_assets_locally` | KEEP (same-page only, legend-required) | +| `_partition_assets_by_caption_bands` | KEEP and REUSE | +| `_score_legend_to_group` | MODIFY: add distance_cluster branch | +| NEW `_filter_figure_assets` | ADD: extract from current inline filter | +| NEW `_cluster_page_assets` | ADD: main clustering logic | +| NEW `_has_text_separator` | ADD: text-block-in-gap detection | +| NEW `_rect_intersection_area` | ADD: helper for text separator | + +--- + +### Task 1: Add `_rect_intersection_area` and `_has_text_separator` + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` — add two new functions after `_asset_gap_below` + +- [ ] **Step 1: Add `_rect_intersection_area` helper** + +Add after `_asset_gap_below` (line ~358): + +```python +def _rect_intersection_area(a: list[float], b: list[float]) -> float: + x1 = max(a[0], b[0]) + y1 = max(a[1], b[1]) + x2 = min(a[2], b[2]) + y2 = min(a[3], b[3]) + return max(0.0, x2 - x1) * max(0.0, y2 - y1) +``` + +- [ ] **Step 2: Add `_has_text_separator`** + +Add after `_rect_intersection_area`: + +```python +def _has_text_separator(a: dict, b: dict, page_blocks: list[dict]) -> bool: + ab = a.get("bbox", [0, 0, 0, 0]) + bb = b.get("bbox", [0, 0, 0, 0]) + a_page = a.get("page") + + a_y1, a_y2 = ab[1], ab[3] + b_y1, b_y2 = bb[1], bb[3] + a_x1, a_x2 = ab[0], ab[2] + b_x1, b_x2 = bb[0], bb[2] + + v_overlap = max(0.0, min(a_y2, b_y2) - max(a_y1, b_y1)) + h_gap = max(0.0, b_x1 - a_x2, a_x1 - b_x2) + h_overlap = max(0.0, min(a_x2, b_x2) - max(a_x1, b_x1)) + v_gap = max(0.0, b_y1 - a_y2, a_y1 - b_y2) + + if v_overlap > 0 and h_gap > 0: + gap_rect = [min(a_x2, b_x2), max(a_y1, b_y1), max(a_x1, b_x1), min(a_y2, b_y2)] + elif h_overlap > 0 and v_gap > 0: + gap_rect = [max(a_x1, b_x1), min(a_y2, b_y2), min(a_x2, b_x2), max(a_y1, b_y1)] + else: + gap_rect = [min(a_x1, b_x1), min(a_y1, b_y1), max(a_x2, b_x2), max(a_y2, b_y2)] + + for block in page_blocks: + if block.get("page") != a_page: + continue + role = block.get("role", "") + if role not in ("body_paragraph", "section_heading", "subsection_heading", + "backmatter_heading", "backmatter_body"): + continue + txt = str(block.get("text", "") or "").strip() + if not txt or len(txt) < 10: + continue + cb = block.get("bbox", [0, 0, 0, 0]) + block_area = max(1.0, (cb[2] - cb[0]) * (cb[3] - cb[1])) + if _rect_intersection_area(gap_rect, cb) / block_area >= 0.3: + return True + return False +``` + +- [ ] **Step 3: Write unit tests for both functions** + +Add to `tests/test_ocr_figures.py`: + +```python +def test_rect_intersection_area(): + from paperforge.worker.ocr_figures import _rect_intersection_area + a = [0, 0, 10, 10] + b = [5, 5, 15, 15] + assert _rect_intersection_area(a, b) == 25.0 + assert _rect_intersection_area(a, [20, 20, 30, 30]) == 0.0 + +def test_has_text_separator_detects_body_between_stacked_assets(): + from paperforge.worker.ocr_figures import _has_text_separator + a = {"bbox": [0, 0, 100, 50], "page": 1} + b = {"bbox": [0, 150, 100, 200], "page": 1} + body = {"bbox": [10, 70, 90, 130], "page": 1, "role": "body_paragraph", "text": "some body text here"} + assert _has_text_separator(a, b, [body]) is True + +def test_has_text_separator_no_block_returns_false(): + from paperforge.worker.ocr_figures import _has_text_separator + a = {"bbox": [0, 0, 100, 50], "page": 1} + b = {"bbox": [0, 150, 100, 200], "page": 1} + assert _has_text_separator(a, b, []) is False + +def test_has_text_separator_side_by_side_body_between(): + from paperforge.worker.ocr_figures import _has_text_separator + a = {"bbox": [0, 0, 100, 200], "page": 1} + b = {"bbox": [300, 0, 400, 200], "page": 1} + body = {"bbox": [130, 50, 270, 150], "page": 1, "role": "body_paragraph", "text": "column text separator"} + assert _has_text_separator(a, b, [body]) is True + +def test_has_text_separator_short_text_ignored(): + from paperforge.worker.ocr_figures import _has_text_separator + a = {"bbox": [0, 0, 100, 50], "page": 1} + b = {"bbox": [0, 150, 100, 200], "page": 1} + short = {"bbox": [10, 70, 90, 130], "page": 1, "role": "body_paragraph", "text": "short"} + assert _has_text_separator(a, b, [short]) is False + +def test_has_text_separator_diagonal_no_false_positive(): + from paperforge.worker.ocr_figures import _has_text_separator + a = {"bbox": [0, 0, 100, 100], "page": 1} + b = {"bbox": [300, 300, 400, 400], "page": 1} + assert _has_text_separator(a, b, []) is False +``` + +- [ ] **Step 4: Run tests** + +```bash +pytest tests/test_ocr_figures.py::test_rect_intersection_area tests/test_ocr_figures.py::test_has_text_separator_detects_body_between_stacked_assets tests/test_ocr_figures.py::test_has_text_separator_no_block_returns_false tests/test_ocr_figures.py::test_has_text_separator_side_by_side_body_between tests/test_ocr_figures.py::test_has_text_separator_short_text_ignored tests/test_ocr_figures.py::test_has_text_separator_diagonal_no_false_positive -v +``` +Expected: all PASS. + +- [ ] **Step 5: Commit** + +```bash +git add paperforge/worker/ocr_figures.py tests/test_ocr_figures.py +git commit -m "feat: add _has_text_separator and _rect_intersection_area for distance clustering" +``` + +--- + +### Task 2: Add `_filter_figure_assets` helper + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` — add new function + +- [ ] **Step 1: Add `_filter_figure_assets`** + +Add after `_media_clusters` (after line ~458): + +```python +def _filter_figure_assets(assets: list[dict]) -> list[dict]: + result = [] + for b in assets: + if b.get("_non_body_media"): + continue + role = b.get("role", "") + if role == "figure_asset": + result.append(b) + elif role == "media_asset": + rl = str(b.get("raw_label", "") or "") + if rl in {"image", "chart", "figure"}: + result.append(b) + elif not rl.strip(): + result.append(b) + elif rl == "table" and ""}, + {"block_id": "table_plain", "role": "media_asset", "raw_label": "table", "text": "plain table"}, + {"block_id": "noise", "role": "noise", "raw_label": "image"}, + {"block_id": "nonbody", "role": "media_asset", "raw_label": "image", "_non_body_media": True}, + ] + result = _filter_figure_assets(assets) + assert [a["block_id"] for a in result] == ["fig", "chart", "empty_label", "table_img"] +``` + +- [ ] **Step 3: Run test** + +```bash +pytest tests/test_ocr_figures.py::test_filter_figure_assets -v +``` +Expected: PASS. + +- [ ] **Step 4: Commit** + +```bash +git add paperforge/worker/ocr_figures.py tests/test_ocr_figures.py +git commit -m "feat: add _filter_figure_assets helper for backward-compatible asset filtering" +``` + +--- + +### Task 3: Add `_cluster_page_assets` + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` — add new function + +- [ ] **Step 1: Add `_cluster_page_assets`** + +Add after `_has_text_separator`: + +```python +def _cluster_page_assets( + page_assets: list[dict], + all_blocks: list[dict], + n_legends: int, + page_width: float, + page_height: float, +) -> list[list[dict]]: + if not page_assets: + return [] + if len(page_assets) == 1: + return [list(page_assets)] + + h_threshold = max(page_width * 0.12, 40.0) + v_threshold = max(min(page_width, page_height) * 0.08, 40.0) + parent = list(range(len(page_assets))) + + def find(x): + while parent[x] != x: + parent[x] = parent[parent[x]] + x = parent[x] + return x + + def union(x, y): + px, py = find(x), find(y) + if px != py: + parent[py] = px + + for i in range(len(page_assets)): + for j in range(i + 1, len(page_assets)): + a, b = page_assets[i], page_assets[j] + ab = a.get("bbox", [0, 0, 0, 0]) + bb = b.get("bbox", [0, 0, 0, 0]) + + h_gap = max(0.0, bb[0] - ab[2], ab[0] - bb[2]) + v_gap = max(0.0, bb[1] - ab[3], ab[1] - bb[3]) + + if h_gap > h_threshold: + if n_legends <= 1: + a_y1, a_y2 = ab[1], ab[3] + b_y1, b_y2 = bb[1], bb[3] + y_overlap = max(0, min(a_y2, b_y2) - max(a_y1, b_y1)) + shorter_h = min(a_y2 - a_y1, b_y2 - b_y1) + if shorter_h > 0 and y_overlap / shorter_h >= 0.5: + if h_gap > page_width * 0.25: + continue + else: + continue + else: + continue + + if v_gap > v_threshold: + continue + + if _has_text_separator(a, b, all_blocks): + continue + + union(i, j) + + clusters: dict[int, list[dict]] = {} + for i, block in enumerate(page_assets): + root = find(i) + if root not in clusters: + clusters[root] = [] + clusters[root].append(block) + + return list(clusters.values()) +``` + +- [ ] **Step 2: Write unit tests** + +```python +def test_cluster_page_assets_2x2_grid(): + assets = [ + {"bbox": [0, 0, 100, 100], "page": 1, "role": "figure_asset"}, + {"bbox": [120, 0, 220, 100], "page": 1, "role": "figure_asset"}, + {"bbox": [0, 120, 100, 220], "page": 1, "role": "figure_asset"}, + {"bbox": [120, 120, 220, 220], "page": 1, "role": "figure_asset"}, + ] + clusters = _cluster_page_assets(assets, [], 1, 1000, 1000) + assert len(clusters) == 1 + assert len(clusters[0]) == 4 + +def test_cluster_page_assets_wide_separation_no_irregular(): + assets = [ + {"bbox": [0, 0, 100, 100], "page": 1, "role": "figure_asset"}, + {"bbox": [500, 0, 600, 100], "page": 1, "role": "figure_asset"}, + ] + clusters = _cluster_page_assets(assets, [], 1, 1000, 1000) + # gap=400 > 250 (25% of 1000), even with y-overlap + assert len(clusters) == 2 + +def test_cluster_page_assets_text_separator_splits(): + assets = [ + {"bbox": [0, 0, 100, 100], "page": 1, "role": "figure_asset"}, + {"bbox": [0, 200, 100, 300], "page": 1, "role": "figure_asset"}, + ] + body = {"bbox": [10, 120, 90, 180], "page": 1, "role": "body_paragraph", "text": "some body text here between figures"} + clusters = _cluster_page_assets(assets, [body], 1, 1000, 1000) + assert len(clusters) == 2 + +def test_cluster_page_assets_irregular_merge(): + assets = [ + {"bbox": [0, 0, 100, 300], "page": 1, "role": "figure_asset"}, + {"bbox": [200, 0, 300, 100], "page": 1, "role": "figure_asset"}, + {"bbox": [200, 120, 300, 220], "page": 1, "role": "figure_asset"}, + {"bbox": [200, 240, 300, 340], "page": 1, "role": "figure_asset"}, + ] + clusters = _cluster_page_assets(assets, [], 1, 1000, 1000) + assert len(clusters) == 1 + assert len(clusters[0]) == 4 + +def test_cluster_page_assets_no_irregular_when_multi_legend(): + assets = [ + {"bbox": [0, 0, 100, 300], "page": 1, "role": "figure_asset"}, + {"bbox": [300, 0, 400, 100], "page": 1, "role": "figure_asset"}, + ] + clusters = _cluster_page_assets(assets, [], 2, 1000, 1000) + assert len(clusters) == 2 +``` + +- [ ] **Step 3: Run tests** + +```bash +pytest tests/test_ocr_figures.py::test_cluster_page_assets_2x2_grid tests/test_ocr_figures.py::test_cluster_page_assets_wide_separation_no_irregular tests/test_ocr_figures.py::test_cluster_page_assets_text_separator_splits tests/test_ocr_figures.py::test_cluster_page_assets_irregular_merge tests/test_ocr_figures.py::test_cluster_page_assets_no_irregular_when_multi_legend -v +``` +Expected: all PASS. + +- [ ] **Step 4: Commit** + +```bash +git add paperforge/worker/ocr_figures.py tests/test_ocr_figures.py +git commit -m "feat: add _cluster_page_assets with distance-based union-find clustering" +``` + +--- + +### Task 4: Rewrite `_build_candidate_figure_groups_from_assets` + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` — replace entire function body + +- [ ] **Step 1: Replace function body** + +Replace the current `_build_candidate_figure_groups_from_assets` (starts at line ~487) with: + +```python +def _build_candidate_figure_groups_from_assets( + assets: list[dict], + all_blocks: list[dict], + legends: list[dict], + page_width: float = 1200, +) -> list[dict]: + media = _filter_figure_assets(assets) + groups: list[dict] = [] + next_id = 1 + + def _estimate_page_height(page_blocks: list[dict]) -> float: + explicit = [float(b["page_height"]) for b in page_blocks if b.get("page_height")] + if explicit: + return max(explicit) + bottoms = [ + float((b.get("bbox") or [0, 0, 0, 0])[3]) + for b in page_blocks if len(b.get("bbox") or []) >= 4 + ] + return max(bottoms, default=1600.0) + + by_page: dict[int, list[dict]] = {} + for block in media: + by_page.setdefault(int(block.get("page", 0) or 0), []).append(block) + + for page, page_media in by_page.items(): + page_blocks = [b for b in all_blocks if int(b.get("page", 0) or 0) == page] + page_height = _estimate_page_height(page_blocks) + + page_legends = [l for l in legends if l.get("page") == page] + n_legends = len(page_legends) + + # Multi-legend: partition by caption bands first + if n_legends >= 2: + band_map = _partition_assets_by_caption_bands(page_legends, page_media, page_height) + partitions: list[tuple[str | None, list[dict]]] = [ + (band_id, list(assets)) for band_id, assets in band_map.items() if assets + ] + assigned_ids = {id(a) for _, p in partitions for a in p} + free = [a for a in page_media if id(a) not in assigned_ids] + if free: + partitions.append((None, free)) + else: + partitions = [(None, list(page_media))] + + # Cluster each partition + page_groups: list[dict] = [] + for band_id, partition in partitions: + if not partition: + continue + clusters = _cluster_page_assets(partition, page_blocks, n_legends, page_width, page_height) + for cluster in clusters: + gt = "distance_cluster" if len(cluster) >= 2 else "single_asset" + entry = _candidate_group_entry( + f"group_{next_id:04d}", page, cluster, gt, + ["same_page", "distance_clustered" if gt == "distance_cluster" else "single_asset"], + ) + entry["caption_band_id"] = band_id + entry["page_legend_count"] = n_legends + entry["safe_auto_match"] = False + page_groups.append(entry) + next_id += 1 + + page_group_count = len(page_groups) + page_distance_cluster_count = sum(1 for g in page_groups if g["group_type"] == "distance_cluster") + for g in page_groups: + g["page_group_count"] = page_group_count + g["page_distance_cluster_count"] = page_distance_cluster_count + g["safe_auto_match"] = ( + n_legends == 1 + and page_group_count == 1 + and g["group_type"] == "distance_cluster" + and len(g.get("media_blocks", [])) >= 2 + ) + + groups.extend(page_groups) + + return groups +``` + +- [ ] **Step 2: Update call site in `build_figure_inventory`** + +Find the call (around line ~1790): + +```python +candidate_groups = _build_candidate_figure_groups_from_assets(assets, page_width=page_width) +``` + +Replace with: + +```python +candidate_groups = _build_candidate_figure_groups_from_assets( + assets, structured_blocks, ordered_legends, page_width=page_width, +) +``` + +- [ ] **Step 3: Run existing figure tests to check for regressions** + +```bash +pytest tests/test_ocr_figures.py -v --tb=short +``` +Expected: existing tests pass (new tests from Tasks 1-3 also pass). + +- [ ] **Step 4: Commit** + +```bash +git add paperforge/worker/ocr_figures.py +git commit -m "refactor: replace greedy region-growing with distance clustering in _build_candidate_figure_groups_from_assets" +``` + +--- + +### Task 5: Modify `_score_legend_to_group` + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` — add distance_cluster branch + +- [ ] **Step 1: Add distance_cluster branch to `_score_legend_to_group`** + +Find `_score_legend_to_group` (line ~608). Add this BEFORE the existing `if gt == "page_assets":` check: + +```python + if gt == "distance_cluster": + num_assets = len(group.get("media_blocks", [])) + if group.get("safe_auto_match") and num_assets >= 2: + return {"score": 0.85, "decision": "matched", + "evidence": ["same_page", "distance_clustered", "safe_auto_match"]} + + cluster_bbox = group.get("cluster_bbox", [0, 0, 0, 0]) + match_score = score_figure_match( + legend, + {"bbox": cluster_bbox, "page": group.get("page", 0)}, + caption_score=caption_score, + anchor_supported=anchor_supported, + caption_text_supported=caption_text_supported, + family_supported=family_supported, + zone_supported=zone_supported, + ) + if num_assets >= 2 and match_score.get("score", 0) > 0: + match_score = dict(match_score) + match_score["score"] = min(1.0, match_score["score"] + 0.15) + match_score.setdefault("evidence", []).append("multi_asset_coherence_bonus") + if match_score["score"] >= 0.5 and match_score.get("decision") in ("candidate", "ambiguous"): + match_score["decision"] = "matched" + return match_score +``` + +- [ ] **Step 2: Run tests** + +```bash +pytest tests/test_ocr_figures.py -v --tb=short +``` +Expected: all PASS. + +- [ ] **Step 3: Commit** + +```bash +git add paperforge/worker/ocr_figures.py +git commit -m "feat: add distance_cluster scoring branch with safe_auto_match" +``` + +--- + +### Task 6: Add group-aware sequential fallback + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` — modify `build_figure_inventory` sequential fallback section + +Insert point: AFTER preproof legend-bundling fallback, BEFORE the existing "Sequential fallback: match unmatched captions to remaining assets" block. + +- [ ] **Step 1: Add `used_group_ids` tracking** + +Near the top of `build_figure_inventory`, after initialization: + +```python +used_group_ids: set[str] = set() +``` + +In the per-page matching loop (same-page match success path), after a group is matched: + +```python +if best_group: + used_group_ids.add(str(best_group.get("group_id", ""))) +``` + +Add in both the close-tie branch and the normal branch. + +- [ ] **Step 2: Add group-aware sequential fallback** + +In `build_figure_inventory`, AFTER the preproof legend-bundling block and BEFORE the existing sequential fallback: + +```python + # === Group-aware sequential fallback === + # Consume unmatched distance_clusters that no same-page legend claimed. + # Inserted AFTER preproof fallback, BEFORE old single-asset sequential fallback. + local_asset_by_page_id: dict[tuple[int, str], dict] = {} + for block in _filter_figure_assets(assets): + local_asset_by_page_id[(int(block.get("page", 0) or 0), str(block.get("block_id", "")))] = block + + unmatched_groups = [ + g for g in candidate_groups + if str(g.get("group_id", "")) not in used_group_ids + and g.get("group_type") == "distance_cluster" + and not any( + (int(g.get("page", 0) or 0), str(bid)) in used_asset_page_ids + for bid in g.get("asset_block_ids", []) + if bid is not None + ) + ] + unmatched_groups.sort(key=lambda g: ( + int(g.get("page", 0) or 0), + (g.get("cluster_bbox") or [0, 0, 0, 0])[1], + )) + + for legend in list(unmatched_legends): + lg_page = int(legend.get("page", 0) or 0) + cap_text = str(legend.get("text", "") or "") + fn = _extract_figure_number(cap_text) + if fn is None: + continue + cap_ns = _extract_figure_namespace(cap_text) + fig_id = _format_figure_id(cap_ns, fn) + + # Collect candidate groups: prefer same-page, then next-page, then previous-page + same_page = [g for g in unmatched_groups if g["page"] == lg_page] + next_page = [g for g in unmatched_groups if g["page"] == lg_page + 1] + prev_page = [g for g in unmatched_groups if g["page"] == lg_page - 1] + + best_group = None + if same_page: + # Same-page group must re-pass scoring to avoid forcing unrelated clusters + for sg in same_page: + sg_score = _score_legend_to_group( + legend, sg, + caption_score=score_figure_caption( + legend, nearby_media=True, caption_style_match=False, + body_prose_likelihood=False, + ), + page_width=page_width, + ) + if sg_score.get("decision") == "matched" and sg_score.get("score", 0.0) >= 0.5: + best_group = sg + break + if best_group is None and next_page: + best_group = next_page[0] + if best_group is None and prev_page: + first_bid = str(prev_page[0]["asset_block_ids"][0]) if prev_page[0]["asset_block_ids"] else "" + first_asset = local_asset_by_page_id.get((prev_page[0]["page"], first_bid)) + if first_asset and _allow_previous_page_sequential_match(legend, first_asset): + best_group = prev_page[0] + + if best_group is None: + continue + + group_page = int(best_group.get("page", 0) or 0) + caption_score = score_figure_caption( + legend, nearby_media=True, caption_style_match=False, + body_prose_likelihood=False, + ) + + group_assets = [] + for bid in best_group.get("asset_block_ids", []): + if bid is None: + continue + asset = local_asset_by_page_id.get((group_page, str(bid))) + if asset: + group_assets.append(asset) + used_asset_page_ids.add((group_page, str(bid))) + + if not group_assets: + continue + + matched_figures.append({ + "figure_id": fig_id, + "figure_namespace": cap_ns, + "legend_block_id": legend.get("block_id", ""), + "page": group_page, + "text": cap_text, + "figure_number": fn, + "matched_assets": [ + {"block_id": a.get("block_id", ""), "bbox": a.get("bbox", [0, 0, 0, 0])} + for a in group_assets + ], + "asset_block_ids": [str(a.get("block_id", "")) for a in group_assets], + "bridge_block_ids": [], + "group_type": best_group.get("group_type", ""), + "group_evidence": best_group.get("group_evidence", []) + ["group_sequential_fallback"], + "cluster_bbox": best_group.get("cluster_bbox", [0, 0, 0, 0]), + "confidence": 0.45, + "match_score": { + "score": 0.45, + "decision": "matched", + "evidence": ["group_sequential_fallback"], + }, + "flags": ["group_sequential_match"], + "caption_score": caption_score, + }) + + used_group_ids.add(str(best_group.get("group_id", ""))) + unmatched_legends.remove(legend) + ambiguous_figures[:] = [ + af for af in ambiguous_figures + if str(af.get("legend_block_id", "")) != str(legend.get("block_id", "")) + ] + + # === End group-aware fallback === +``` + +--- + +### Task 7: Delete obsolete functions + +**Files:** +- Modify: `paperforge/worker/ocr_figures.py` — remove `_grow_region_from_seed`, `_validate_grown_region`, `_asset_gap_left`, `_asset_gap_above` + +- [ ] **Step 1: Delete the obsolete functions** + +Remove: +- `_grow_region_from_seed` (line ~361-389) +- `_validate_grown_region` (line ~392-413) +- `_asset_gap_left` (line ~new, added in previous fix) +- `_asset_gap_above` (line ~new, added in previous fix) + +- [ ] **Step 2: Verify `_media_clusters` still exists and is unchanged** + +`_media_clusters` at line ~416 should still be there. If it was accidentally removed during Task 4 edits, restore it. + +- [ ] **Step 3: Run tests** + +```bash +pytest tests/test_ocr_figures.py -v --tb=short +``` +Expected: all PASS. + +- [ ] **Step 4: Commit** + +```bash +git add paperforge/worker/ocr_figures.py +git commit -m "refactor: remove obsolete _grow_region_from_seed, _validate_grown_region, gap helpers" +``` + +--- + +### Task 8: Add production replay regression tests + +**Files:** +- Modify: `tests/test_ocr_real_paper_regressions.py` — add tests for SAN9AYVR, 2GN9LMCW, DWQQK2YB, 3FDT9652 + +- [ ] **Step 1: Add SAN9AYVR Figure 23 merge test** + +```python +def test_san9ayvr_figure_23_all_panels_merged(tmp_path: Path) -> None: + from paperforge.worker.ocr_figures import build_figure_inventory + result = replay_production_pipeline("SAN9AYVR", tmp_path) + inventory = result["figure_inventory"] + + fig23 = [f for f in inventory["matched_figures"] if f.get("figure_number") == 23] + assert len(fig23) == 1, "Figure 23 should be a single matched figure" + assert len(fig23[0].get("matched_assets", [])) >= 8, "Figure 23 should have 8+ sub-panels" + assert fig23[0].get("group_type") == "distance_cluster", ( + f"Figure 23 should be distance_clustered, got {fig23[0].get('group_type')}" + ) +``` + +- [ ] **Step 2: Add 2GN9LMCW Figure 4 merge test** + +```python +def test_2gn9lmcw_figure_4_six_assets_merged(tmp_path: Path) -> None: + result = replay_production_pipeline("2GN9LMCW", tmp_path) + inventory = result["figure_inventory"] + + fig4 = [f for f in inventory["matched_figures"] if f.get("figure_number") == 4] + assert len(fig4) == 1, "Figure 4 should be matched" + assert len(fig4[0].get("matched_assets", [])) >= 6, "Figure 4 should have 6+ assets" + assert fig4[0].get("group_type") == "distance_cluster" +``` + +- [ ] **Step 3: Add DWQQK2YB Figure 2 regression test** + +```python +def test_dwqqk2yb_figure_2_on_correct_page(tmp_path: Path) -> None: + result = replay_production_pipeline("DWQQK2YB", tmp_path) + inventory = result["figure_inventory"] + + fig2 = [f for f in inventory["matched_figures"] if f.get("figure_number") == 2] + assert len(fig2) == 1, "Figure 2 should be matched" + assert fig2[0]["page"] == 38, f"Figure 2 should be on page 38, got page {fig2[0]['page']}" + assert len(fig2[0].get("matched_assets", [])) >= 18, ( + f"Figure 2 should have 18+ assets, got {len(fig2[0].get('matched_assets', []))}" + ) +``` + +- [ ] **Step 4: Add 3FDT9652 multi-column regression test** + +```python +def test_3fdt9652_multi_column_figures_not_merged(tmp_path: Path) -> None: + result = replay_production_pipeline("3FDT9652", tmp_path) + inventory = result["figure_inventory"] + unmatched = inventory.get("unmatched_legends", []) + + # 3FDT9652 page 3 should have Figure 2 and Figure 3 as separate matched figures + fig2 = [f for f in inventory["matched_figures"] if f.get("figure_number") == 2] + fig3 = [f for f in inventory["matched_figures"] if f.get("figure_number") == 3] + + assert len(fig2) == 1, "Figure 2 should be matched" + assert len(fig3) == 1, "Figure 3 should be matched" + + # They should NOT share any asset block + fig2_assets = {str(a.get("block_id", "")) for a in fig2[0].get("matched_assets", [])} + fig3_assets = {str(a.get("block_id", "")) for a in fig3[0].get("matched_assets", [])} + assert fig2_assets.isdisjoint(fig3_assets), ( + f"Fig 2 and Fig 3 share assets: {fig2_assets & fig3_assets}" + ) + + # Each should have different legend_block_id + assert fig2[0].get("legend_block_id") != fig3[0].get("legend_block_id"), ( + "Fig 2 and Fig 3 share the same legend_block_id" + ) +``` + +- [ ] **Step 5: Run production replay tests** + +```bash +pytest tests/test_ocr_real_paper_regressions.py -v --tb=short -k "figure|merge|cluster" +``` +Expected: all PASS (or skip if fixture data unavailable). + +- [ ] **Step 6: Commit** + +```bash +git add tests/test_ocr_real_paper_regressions.py +git commit -m "test: add production replay tests for distance clustering merge" +``` + +--- + +### Task 9: Full regression run + +**Files:** None (run test suite) + +- [ ] **Step 1: Run full test suite** + +```bash +pytest tests/test_ocr_figures.py tests/test_ocr_real_paper_regressions.py -v --tb=short +``` +Expected: all PASS. + +- [ ] **Step 2: Run full paperforge test suite** + +```bash +python -m pytest tests/ -v --tb=short 2>&1 | tail -30 +``` +Expected: no regressions introduced. + +- [ ] **Step 3: Final commit (if any fixes needed)** + +```bash +git add -A +git commit -m "chore: final fixes after full regression run" +``` + +--- + +## Summary of all commits + +| Task | Commit message | Files | +|------|---------------|-------| +| 1 | `feat: add _has_text_separator and _rect_intersection_area` | `ocr_figures.py`, `test_ocr_figures.py` | +| 2 | `feat: add _filter_figure_assets helper` | `ocr_figures.py`, `test_ocr_figures.py` | +| 3 | `feat: add _cluster_page_assets with union-find` | `ocr_figures.py`, `test_ocr_figures.py` | +| 4 | `refactor: replace region-growing with distance clustering` | `ocr_figures.py` | +| 5 | `feat: add distance_cluster scoring branch` | `ocr_figures.py` | +| 6 | `feat: add group-aware sequential fallback` | `ocr_figures.py` | +| 7 | `refactor: remove obsolete grow/validate helpers` | `ocr_figures.py` | +| 8 | `test: add production replay regression tests` | `test_ocr_real_paper_regressions.py` | +| 9 | `chore: final regression fixes` | Various | + +## Post-implementation verification + +After all tasks are done, verify against acceptance criteria: + +1. ✅ SAN9AYVR Figure 23: all expected sub-panels matched (production test) +2. ✅ 2GN9LMCW Figure 4: 6+ assets merged (production test) +3. ✅ DWQQK2YB Figure 2: page 38, 10+ assets (production test) +4. ✅ 3FDT9652: no cross-figure asset overlap (production test) +5. ✅ Unit tests: 2x2 cluster, text separator, irregular merge, multi-legend partition +6. ✅ No page-swallow regression (existing test suite) diff --git a/docs/superpowers/specs/2026-06-19-ocr-maintenance-ux-design.md b/docs/superpowers/specs/2026-06-19-ocr-maintenance-ux-design.md new file mode 100644 index 00000000..16d01a5b --- /dev/null +++ b/docs/superpowers/specs/2026-06-19-ocr-maintenance-ux-design.md @@ -0,0 +1,446 @@ +# OCR Maintenance UX Design + +> Date: 2026-06-19 +> Status: draft written from approved chat direction, pending user review +> Scope: redesign the plugin Settings -> Maintenance tab so ordinary research users can quickly judge whether anything needs action, understand why, and avoid being pushed toward maintenance actions that are unlikely to help. + +## Goal + +Turn the current OCR maintenance tab from an engineer-facing repair console into a user-facing maintenance decision surface. + +The new tab should answer three user questions in order: + +1. Do I need to do anything? +2. If yes, which papers are worth acting on? +3. Why is the system recommending action for those papers? + +The design priority is: + +1. one-glance overall judgment, +2. then explanation, +3. then optional deep technical detail. + +## Target User + +Primary target user: ordinary research users, not the developer maintaining the OCR pipeline. + +This means the default screen should not assume the user understands: + +- `green / yellow / red`, +- `done_degraded`, +- `derived_stale`, +- structural gate terminology, +- layout audit terminology, +- rebuild vs redo implementation details. + +The interface should translate internal OCR state into user decision language. + +## Core Product Principle + +The maintenance tab should default to surfacing only problems where user action is likely to help. + +In other words: + +- actionable problems should be promoted, +- non-actionable quality caveats should be explained but not escalated, +- users should not be pressured to perform maintenance just because a paper fails a strict health heuristic. + +Operational shorthand: + +> Only interrupt the user for problems that are likely to improve after action. + +## Current Problem + +The current maintenance tab in `paperforge/plugin/src/settings.ts` is already functionally capable, but its UX is oriented around raw OCR maintenance rows and internal state fields. + +Current issues: + +1. The tab leads with a full table rather than a conclusion. +2. The user must infer whether a paper needs action from low-level fields. +3. `health`-adjacent badges are visually prominent, but they do not distinguish between: + - rebuild-fixable issues, + - true OCR failures, + - structurally noisy papers where maintenance may not help. +4. The UI encourages users to interpret any warning-like state as a repair task. +5. The existing “recommended action” signal exists in backend data, but it is not the primary organizing principle of the interface. + +## Important Domain Truth + +`health` is not the same thing as user-facing normality. + +Current OCR health logic in `paperforge/worker/ocr_health.py` mixes: + +- structural completeness heuristics, +- risk signals for weak layout confidence, +- figure/table confidence issues, +- role gate degradation, +- layout-class sensitivity. + +This is useful engineering evidence, but it is not a reliable direct UI verdict for ordinary users. + +Some papers will naturally score worse on health-style heuristics because of complex layout or genre, even when maintenance actions are unlikely to improve the result. + +Therefore: + +- `green` must not be treated as the only “normal” outcome, +- `yellow` must not automatically imply “user should do something”, +- `red` must be interpreted alongside actionability, not in isolation. + +## UX Decision Model + +The maintenance tab should classify each paper by actionability first, not by raw health color. + +### User-Facing Categories + +Each paper should land in one of four user-facing categories: + +1. `No Action Needed` +2. `Rebuild Recommended` +3. `OCR Failed` +4. `Result Limited` + +### Category Definitions + +#### 1. No Action Needed + +Use when: + +- OCR completed, +- there is no clear recommended action, +- and the system does not have strong evidence that user maintenance will help. + +This category may include papers that are not perfectly “green” internally, as long as the system does not have a concrete, useful intervention to propose. + +#### 2. Rebuild Recommended + +Use when: + +- backend `recommended_action == "rebuild"`. + +This is the highest-priority actionable category for ordinary users because rebuild is lower-cost and more deterministic than rerunning OCR. + +The UI should treat rebuild as the main proactive action type. + +#### 3. OCR Failed + +Use when: + +- OCR clearly failed, +- and retrying OCR is the only meaningful next step. + +Redo should only be proactively suggested in true failure scenarios. + +This reflects the approved UX rule: + +> redo is not proactively promoted unless OCR clearly failed. + +#### 4. Result Limited + +Use when: + +- the paper shows warning/degraded signals, +- but the system has no concrete reason to believe rebuild or redo will help. + +This category exists to explain limitations without turning them into false maintenance tasks. + +Examples: + +- complex layout, +- weak confidence signals, +- strict health heuristics failing on papers that are still usable, +- degraded reasons that do not map to a high-confidence maintenance action. + +## Mapping from Existing Backend Signals + +The existing backend already exposes the most important actionability field via `recommended_action` in `paperforge/worker/ocr_maintenance.py`. + +The redesigned UI should map fields as follows: + +### Primary decision fields + +- `recommended_action` +- `ocr_status` + +### Secondary evidence fields + +- `health` +- `degraded_reasons` +- `error_summary` +- `error_stage` +- `version` +- `finished_at` +- `model` + +### Required mapping behavior + +1. `recommended_action == "rebuild"` -> `Rebuild Recommended` +2. explicit OCR failure with redo-worthy state -> `OCR Failed` +3. warning/degraded signals without recommended action -> `Result Limited` +4. completed items without actionable recommendation -> `No Action Needed` + +### Explicit non-goal + +The UI should not use `green / yellow / red` as the primary category system. + +Those may remain visible only inside expanded technical evidence. + +## Information Architecture + +The tab should be reordered into four vertical sections. + +### Section 1: Overall Conclusion Card + +This is the first screenful priority. + +Contents: + +- one sentence overall conclusion, +- three primary counts, +- one short explanation note. + +#### Example conclusion copy + +- `OCR is mostly in good shape. 2 papers are recommended for rebuild.` +- `OCR has 1 failed paper that needs attention.` +- `OCR looks usable overall. Some papers have limitations, but no maintenance is currently recommended.` + +#### Primary counts + +- `No Action Needed` +- `Rebuild Recommended` +- `OCR Failed` + +`Result Limited` should be shown as secondary supporting information, not as a primary alert metric. + +#### Required helper note + +Add a short note under the summary: + +> This page only promotes issues where maintenance is likely to help. Some papers may have limitations that are not meaningfully improved by rerunning maintenance. + +### Section 2: Needs Attention + +This section shows only actionable papers: + +- `Rebuild Recommended` +- `OCR Failed` + +This is the main operational list for ordinary users. + +Do not show all papers here. + +Each row/card should answer: + +1. What is the problem? +2. What should I do? +3. Why is that action recommended? + +#### Required fields per row/card + +- paper title, +- user-facing category, +- one-line explanation, +- primary action button, +- `View why` / `View details` disclosure. + +#### Example explanation copy + +- `Derived OCR results are stale. Rebuild should regenerate them from existing OCR data.` +- `OCR failed before completion. Rerunning OCR is the only useful next step.` + +### Section 3: Result Limitations + +This section lists papers in `Result Limited`. + +Purpose: + +- explain caveats, +- avoid false repair pressure, +- build trust that the system can say “this is imperfect, but maintenance may not help.” + +Required section intro: + +> These papers show weaker confidence or more complex structure, but PaperForge does not currently have a high-confidence maintenance action to recommend. + +Each entry can be lighter-weight than the actionable list, but should still provide: + +- paper title, +- concise limitation summary, +- `View why` disclosure. + +No primary maintenance button should appear by default in this section. + +### Section 4: All Papers + +The current table-like detailed view should remain available, but be moved into a collapsed advanced section. + +Purpose: + +- preserve power-user inspection, +- preserve developer debugging value, +- avoid making the whole tab feel like a backend console. + +This section should default to collapsed. + +## Row/Card Content Rules + +The redesigned default paper item should be card-oriented or at least row-oriented around decision clarity rather than dense columns. + +Default visible content should be limited to: + +1. title, +2. user-facing verdict, +3. concise reason, +4. action button if actionable, +5. disclosure for supporting evidence. + +Do not require the user to interpret a wide table to understand next steps. + +## Progressive Disclosure + +Technical evidence is still valuable, but should be hidden behind an explicit expand action. + +### Expanded details should contain + +- internal OCR status, +- internal health summary, +- degraded reasons, +- error summary / stage when present, +- model, +- version, +- recent completion time, +- any backend recommendation rationale already available from current data. + +### Expanded details should not be primary UI + +These are diagnostic materials, not first-pass decision materials. + +## Terminology Rules + +The interface should shift from system terminology to user decision terminology. + +### Terms to avoid in default view + +- `green` +- `yellow` +- `red` +- `done_degraded` +- `derived_stale` +- `role gate degraded` +- `weak body spine` +- `layout audit` +- `reader_figure_coverage_gap` + +These may appear only inside expanded details. + +### Preferred user-facing terms + +- `No Action Needed` +- `Rebuild Recommended` +- `OCR Failed` +- `Result Limited` +- `Recommended action` +- `Why this is recommended` + +### Specific action labels + +- `Rebuild results` +- `Rerun OCR` + +These labels are clearer than generic “fix” phrasing and more honest about what the action actually does. + +## Required Explanatory Copy + +The redesign must explicitly explain the difference between rebuild and rerun OCR. + +### Rebuild explanation + +Add nearby helper copy: + +> Rebuild regenerates derived OCR results from existing OCR raw data. It does not call the OCR service again. + +### Rerun OCR explanation + +Add nearby helper copy: + +> Rerun OCR is only recommended when OCR clearly failed. It costs more and may not produce a better result unless the previous run failed. + +### Result Limited explanation + +Add helper copy: + +> Some papers have unusual layouts or weaker confidence signals. That does not always mean maintenance can improve them. + +## Interaction Behavior + +### Filters + +Default filter should prioritize the actionability sections rather than raw badge filtering. + +If a filter control remains, it should expose user-facing categories first: + +- All papers +- Needs attention +- Result limited +- No action needed + +Avoid exposing raw internal badge strings as top-level filter choices. + +### Bulk actions + +Bulk actions should operate only on clearly actionable items. + +Rules: + +1. bulk rebuild should only target `Rebuild Recommended` items, +2. bulk rerun OCR should only appear for failed papers, +3. “select all” should not silently include non-actionable warning-only papers. + +## Data/Logic Constraints + +This UX redesign does not require inventing a new backend health system. + +The design should reuse existing backend fields wherever possible, especially: + +- `recommended_action`, +- `status`, +- `degraded_reasons`, +- `error_summary`, +- `error_stage`, +- `version`. + +Minimal additional logic is acceptable if needed to map backend rows into the four user-facing categories, but the design should avoid a deep new maintenance state machine. + +## Non-Goals + +This design does not: + +- redefine OCR health computation, +- promise that all papers can become green, +- hide all technical detail from power users, +- remove the existing detailed table entirely, +- change OCR pipeline backend semantics beyond what is necessary to present them clearly. + +## Acceptance Criteria + +The redesign is successful when: + +1. a first-time ordinary user can tell within a few seconds whether maintenance is needed, +2. actionable items are visually separated from non-actionable quality caveats, +3. rebuild-worthy items are promoted more strongly than redo-worthy items, +4. redo is proactively surfaced only for clear failure cases, +5. warning-like health signals without a useful intervention no longer create false repair pressure, +6. full technical details remain available through disclosure for debugging and trust-building. + +## Implementation Notes + +The current implementation hotspot is `paperforge/plugin/src/settings.ts`, especially `_renderMaintenanceTab()`. + +The likely implementation direction is: + +1. keep the existing maintenance row backend model, +2. add a small UI-side category mapper based on actionability, +3. replace the current table-first rendering with summary-first rendering, +4. preserve the existing detailed table inside an advanced collapsed section. + +This keeps the diff small while aligning the UX with the approved product logic. diff --git a/docs/superpowers/specs/2026-06-19-ocr-rebuild-audit-remediation-design.md b/docs/superpowers/specs/2026-06-19-ocr-rebuild-audit-remediation-design.md new file mode 100644 index 00000000..bbabb6b1 --- /dev/null +++ b/docs/superpowers/specs/2026-06-19-ocr-rebuild-audit-remediation-design.md @@ -0,0 +1,459 @@ +# OCR Rebuild Audit Remediation Design + +> Date: 2026-06-19 +> Status: executed on `ocr-v2` +> Scope: convert the 2026-06-19 full rebuild audit into a constrained remediation design for OCR rebuild outputs and health semantics + +## Goal + +Stabilize the rebuild output layer after the 452-paper audit without reopening the OCR-v2 backbone redesign. + +This design treats the current rebuild issues as a post-readiness hardening pass over four surfaces: + +1. ownership outputs, +2. render projection, +3. health semantics, +4. high-risk figure/table inventory edge cases. + +The goal is to remove user-visible output pollution, reduce false red/yellow health noise, and close the most important inventory gaps while preserving the anchor-first OCR-v2 architecture. + +## Non-Goals + +This design does not: + +- redesign the anchor-first OCR-v2 backbone, +- reintroduce early semantic role guessing, +- add text-pattern rescue logic for classification, +- reopen the completed readiness-gate storyline, +- solve every low-severity edge case found in the full corpus audit. + +## Hard Constraint: No Free-Form Text Rescue Logic + +This is a design invariant. + +New fixes in this pass must not use free-form text content as the primary basis for deciding semantic role or ownership. + +Allowed controlled text use: + +- extracting figure/table namespace and numbers from blocks whose role is already determined, +- extracting continuation markers from blocks whose role is already determined, +- extracting reference-item numbering after reference-role candidacy is already established structurally, +- formatting already-owned captions, legends, or notes for render output. + +Disallowed text use: + +- introducing new semantic classification rules based on phrases or publisher-specific wording, +- rescuing ownership by matching prose content, +- deciding whether a block is a footnote/table note/figure note/body paragraph from text alone. + +The repair surface must stay anchored in existing structure evidence: role, zone, marker signature, style family, page geometry, accepted document structure, and inventory ownership outcomes. Text is permitted only as controlled marker parsing after structural candidacy already exists. + +## Current Assessment + +The 2026-06-19 rebuild audit does not show that OCR-v2 is architecturally wrong. + +It shows that the post-structure output path still has shallow seams: + +- ownership evidence is discovered in one module and dropped in another, +- render still contains correctness-affecting policy, +- health still re-infers quality from weak proxies, +- some figure/table inventory cases still use fragile generic heuristics. + +The framework backbone remains: + +```text +raw observations +-> structural signatures +-> stable anchors / families +-> zone inference +-> late role resolution +-> figure / table validation +-> render + health +``` + +This remediation pass stays inside the last three stages. + +## Problem Breakdown + +### 1. Ownership output is incomplete + +The audit confirmed that `ocr_tables.py` already detects adjacent note blocks and records `note_block_ids`, but downstream consumers ignore them. + +Effects: + +- table notes remain outside the table object, +- footnotes leak into body flow, +- fulltext and object render disagree about what belongs to a table. + +This is not primarily a detection failure. It is an ownership write-through failure. + +### 2. Render projection still carries correctness policy + +`ocr_render.py` still decides too much: + +- which roles skip body flow, +- how table captions appear in fulltext, +- how reference tail ordering is imposed. + +Effects: + +- table captions duplicate into fulltext as blockquotes, +- footnotes become body text, +- reference ordering can be wrong even when structure is mostly right. + +### 3. Health semantics are too shallow + +The health model still uses weak binary gates and weak proxy fields: + +- only `section_heading` contributes to heading count, +- a single `raw_label == "reference_content"` can satisfy references, +- `figure_asset_count` is a misleading name for matched-figure count, +- `> 0` issue gates punish tiny and severe failures equally. + +Effects: + +- false red/yellow inflation, +- poor maintenance prioritization, +- rebuild audit output that overstates some defects and understates others. + +### 4. A small set of inventory rules still creates outsized trust risk + +The audit isolated four high-leverage inventory issues: + +1. bare `Table N` captions are treated as too weak even when geometry is strong, +2. supplementary figure numbering collides with main-figure numbering, +3. `page_assets` grouping is too dangerous without strict gates, +4. figure/table assets can still conceptually compete without one explicit arbitration surface. + +These are not invitations to add textual heuristics. They are invitations to tighten ownership contracts. + +## Design Principles + +### Principle 1: Ownership is the truth surface + +If a table note, figure asset, or table asset is discovered during inventory construction, that ownership outcome must survive into: + +- structured writeback when needed, +- object markdown generation, +- fulltext rendering, +- health accounting. + +No downstream module should have to rediscover ownership from raw blocks. + +### Principle 2: Render is a projection module, not a rescue module + +Render should consume: + +- accepted structured roles, +- accepted document structure, +- accepted figure/table inventory outcomes. + +Render should not compensate for weak ownership or weak structure by adding fresh correctness logic. + +### Principle 3: Health should consume explicit outcomes, not weak side effects + +Health fields should derive from: + +- accepted reference/body/tail structure, +- explicit inventory outcome buckets, +- explicit heading-role counts, +- explicit matched/held/unmatched counts. + +The health surface should become more interpretable, not more magical. + +### Principle 4: Geometry and structure beat prose + +When deciding ownership or match confidence in this pass, prefer: + +- page, +- column, +- bbox relation, +- zone, +- style family, +- marker signature, +- already-accepted role. + +Do not compensate with phrase-based rescue logic. + +## Remediation Scope + +### Phase A: Output pollution fixes + +This is the first execution batch because it removes visible corruption with low architectural risk. + +Included: + +1. footnote blocks that belong to table notes must stop rendering as body text, +2. fulltext table-caption blockquote duplication must be removed, +3. table object markdown must render owned notes, +4. heading count must include `section_heading`, `subsection_heading`, and `sub_subsection_heading`. + +Expected result: + +- cleaner fulltext, +- lower visible noise, +- immediate reduction in misleading health failures. + +### Phase B: Inventory contract hardening + +This batch fixes small contract defects with high leverage. + +Included: + +1. `Table N` captions may match only under strong geometry and ownership evidence, +2. supplementary and extended-data figures must split from the main-figure namespace, +3. `page_assets` grouping must be gated tightly or demoted out of strict ownership, +4. inventory outcomes must be made explicit enough for completeness accounting. + +Expected result: + +- fewer false unmatched tables, +- no main/supplementary collisions, +- less risk of one legend swallowing a whole page. + +### Phase C: Semantics cleanup for health and ordering + +This is important but belongs after Phases A-B because it depends on better ownership truth. + +Included: + +1. reference ordering should prefer explicit numbering when present, +2. fallback reference ordering should use layout authority appropriate to single-column vs two-column reference zones, +3. `references_found` should depend on accepted structure rather than one raw label, +4. health issue scoring should move toward ratio/weighted semantics. + +Expected result: + +- health reports become maintenance-meaningful, +- reference-tail errors become easier to debug, +- green/yellow/red becomes less arbitrary. + +## Required Figure Namespace And Outcome Contracts + +To support render and health correctly, the inventory surfaces should separate namespace from outcome. + +### Figure namespace / kind + +At minimum, numbered figure candidates in this pass must be representable as: + +- `main` +- `supplementary` +- `extended_data` +- `unknown` + +`supplementary` is not an ownership outcome. It is a namespace/kind that can independently be matched, held, ambiguous, or unmatched. + +### Ownership outcome + +At minimum, numbered ownership candidates in this pass must be representable as: + +- `matched` +- `matched_low_confidence` +- `held` +- `ambiguous` +- `unmatched` +- `rejected` +- `deduped_duplicate` + +Not every file must use identical field names internally, but the emitted semantics must be complete enough that: + +- completeness does not guess why something disappeared, +- render does not need to infer missing ownership states, +- audits can distinguish “missing” from “intentionally excluded”. + +## Required Table Note Ownership Contract + +The table-note path must stop at a complete ownership contract rather than a dead identifier list. + +`ocr_tables.py` should emit, at minimum: + +- `note_block_ids` +- either `note_blocks` or `note_texts` for downstream render consumption +- a consumed-block surface that includes `caption_block_id`, `asset_block_id`, and `note_block_ids` + +The downstream contract is: + +- `ocr_objects.py` consumes owned table notes and renders them under a dedicated notes section in the table object markdown +- `ocr_render.py` skips any block already consumed by table ownership when projecting body flow +- `ocr_health.py` counts owned notes as consumed ownership, not as free-floating body pollution + +Keeping only `note_block_ids` is insufficient because the current failure mode is precisely that discovery exists but no projection consumer uses it. + +## Required Bare `Table N` Matching Contract + +Bare `Table N` captions may match only when all of the following are satisfied: + +1. the caption block is already a `table_caption`, `table_caption_candidate`, or validation-first table candidate, +2. the candidate asset is already a `table_asset` or has accepted table-like raw-label evidence such as `table` or `table_image`, +3. the caption/asset relation is same-page or an accepted continuation-page relation, +4. the caption and asset have strong horizontal overlap, +5. the asset is below the caption unless an accepted previous-page continuation geometry is in effect, +6. there is no close competing asset within the ambiguity threshold. + +This rule exists to prevent a weak bare caption from swallowing nearby figure assets. + +## Required `page_assets` Gate + +`page_assets` must not produce strict matched ownership unless at least one of the following is true: + +1. exactly one formal figure legend exists on that page, +2. expected panel count closely matches page asset count, +3. no competing figure/table caption candidates exist on the page. + +If those gates are not satisfied, `page_assets` may only emit reader-level grouped evidence, not strict ownership. + +This keeps page-level grouping from becoming a page-swallow path. + +## File Responsibilities + +### `paperforge/worker/ocr_tables.py` + +Owns: + +- table caption matching, +- table asset ownership, +- adjacent table-note ownership, +- table inventory outcome emission, +- consumed-table-block contract emission. + +Must not: + +- rely on prose pattern rescue, +- emit downstream-only dead fields. + +### `paperforge/worker/ocr_figures.py` + +Owns: + +- figure numbering namespace, +- figure group candidate generation, +- legend-to-asset ownership outcomes, +- completeness accounting inputs. + +Must not: + +- introduce text-pattern role rescue, +- leave grouped-vs-single outcomes too implicit for health. + +### `paperforge/worker/ocr_objects.py` + +Owns: + +- object markdown projection for figures and tables. + +Must consume: + +- table note ownership already decided upstream, +- namespace-aware figure/table identity already decided upstream. + +### `paperforge/worker/ocr_render.py` + +Owns: + +- projection of accepted ownership and structure into fulltext. + +Must stop owning: + +- duplicated table-caption policy, +- body leakage for owned note blocks. + +### `paperforge/worker/ocr_health.py` + +Owns: + +- maintenance-facing summary semantics. + +Must become: + +- explicit about what it is counting, +- less dependent on weak proxy checks. + +## Health V2 Compatibility Rule + +The first health pass in this remediation cycle should be backward-compatible. + +Required approach: + +- add corrected counters such as total heading count across all heading tiers, +- rename or parallelize misleading fields such as matched-figure count, +- add ratio/weighted or issue-breakdown-v2 style fields, +- tighten `references_found` to accepted reference evidence, +- keep the current top-level `overall` surface compatible until the richer fields are proven. + +This is a semantics-deepening step, not a permission slip for a large breaking health rewrite. + +## Acceptance Criteria + +This design is successful when all of the following are true: + +1. Table notes owned by table inventory appear in table object markdown and no longer leak into body flow. +2. Fulltext no longer emits blockquote table captions before table embeds on normal display-zone tables. +3. Heading health counts all three heading tiers. +4. Bare `Table N` captions can match only under the explicit strong-geometry contract and without introducing free-form text rescue. +5. Supplementary figure numbering no longer collides with main figures because namespace/kind is separated from outcome. +6. `page_assets` no longer acts as an unrestricted page swallow path. +7. `references_found` no longer passes from one weak raw label alone. +8. Health output becomes more interpretable for the rebuild audit surface through additive or compatibility-preserving v2 fields before any top-level scoring replacement. + +## Execution Order + +The implementation plan should sequence the work in this order: + +1. output pollution fixes, +2. ownership write-through fixes, +3. inventory contract hardening, +4. health and reference semantics cleanup, +5. audit-facing doc updates for the rebuild queue. + +This order is deliberate: + +- first remove visible corruption, +- then make ownership authoritative, +- then tighten health semantics once ownership truth is stable. + +## Risks + +### Risk 1: Hidden dependency on dead fields + +If any downstream consumer implicitly expects the current weak output shapes, making ownership explicit may expose previously hidden assumptions. + +Mitigation: + +- keep changes localized to existing ownership consumers, +- add focused tests for render/object/health projections. + +### Risk 2: Over-correcting with page-level figure grouping + +The current `page_assets` patch is high risk precisely because it improves recall by weakening ownership boundaries. + +Mitigation: + +- gate it strictly, +- or reduce it to a non-strict candidate/reference path rather than a direct ownership path. + +### Risk 3: Reintroducing text heuristics through “small convenience” fixes + +This would violate the core architectural direction and quickly rot. + +Mitigation: + +- treat the no-text-matching rule as hard review criteria for every remediation step. + +## Out of Scope Residuals + +The following may remain after this pass and should not block the design unless they rise to trust-risk level: + +- low-severity audit-truth drift blocks, +- conservative backmatter-heading taxonomy, +- isolated corpus-specific edge cases that do not create new failure families. + +## References + +- `project/current/ocr_rebuild_audit.md` +- `project/current/ocr-v2-closeout-priority.md` +- `project/current/ocr-v2-generalization-boundary.md` +- `paperforge/worker/ocr_tables.py` +- `paperforge/worker/ocr_figures.py` +- `paperforge/worker/ocr_render.py` +- `paperforge/worker/ocr_objects.py` +- `paperforge/worker/ocr_health.py` diff --git a/docs/superpowers/specs/2026-06-19-ocr-truth-surface-realignment-design.md b/docs/superpowers/specs/2026-06-19-ocr-truth-surface-realignment-design.md new file mode 100644 index 00000000..81a80743 --- /dev/null +++ b/docs/superpowers/specs/2026-06-19-ocr-truth-surface-realignment-design.md @@ -0,0 +1,366 @@ +# OCR Truth Surface Realignment Design + +> Date: 2026-06-19 +> Status: executed on `ocr-v2` +> Scope: realign the OCR-v2 project truth files so rebuild-audit work and readiness-gate completion can coexist without narrative conflict + +## Goal + +Create one coherent project truth surface for OCR-v2. + +The repo must stop forcing readers to choose between two half-compatible stories: + +1. OCR-v2 completed all readiness gates and passed blind audit. +2. The 452-paper rebuild audit opened a new queue of post-readiness remediation work. + +Both can be true, but only if the files explicitly distinguish framework readiness from rebuild-output hardening. + +This realignment is intentionally narrow. It is not a broad documentation rewrite project. + +## Non-Goals + +This design does not: + +- change OCR algorithm behavior, +- decide exact code patches for the rebuild findings, +- reopen the readiness model itself, +- turn every historical doc into a fresh spec, +- rewrite the technical analysis bodies of historical files. + +## Execution-Range Constraint + +This design must stay small. + +Allowed edits: + +- headers, +- status lines, +- “Next Work” / active queue sections, +- cross-links, +- contradictory wording that misstates the active truth. + +Disallowed edits: + +- rewriting historical technical analysis bodies for style, +- re-explaining already completed readiness-gate technical details, +- turning truth-surface cleanup into a repo-wide prose modernization pass. + +## Problem Statement + +The current repo truth surface is split across: + +- `PROJECT-MANAGEMENT.md` +- `project/current/ocr-v2-closeout-priority.md` +- `project/current/ocr-v2-generalization-boundary.md` +- `project/current/ocr-v2-remaining-issues-2026-06-18.md` +- `project/current/ocr_rebuild_audit.md` + +These files no longer operate at the same level. + +Some files speak about: + +- branch-level architecture readiness, +- known-layout confidence, +- blind audit completion, + +while the new rebuild audit speaks about: + +- full-corpus output quality, +- health false positives, +- ownership write-through defects, +- post-gate hardening priorities. + +The missing piece is not more analysis. It is a clean separation of evaluation surfaces. + +## Core Distinction To Preserve + +The repo must distinguish these two claims explicitly. + +### Claim A: OCR-v2 framework readiness + +Meaning: + +- the anchor-first architecture is the right backbone, +- the known readiness gates are complete, +- unseen-paper blind audit did not reveal new failure families, +- the branch is no longer blocked on pre-readiness architectural uncertainty. + +### Claim B: rebuild-output hardening remains + +Meaning: + +- the broader rebuild corpus still reveals output-layer defects, +- these defects are mostly post-structure and post-ownership contract problems, +- they justify more work before a “production-polished rebuild surface” claim, +- they do not invalidate the readiness-gate conclusion. + +The repo should never again imply that Claim B automatically negates Claim A. + +## Design Principle: One Question Per Truth File + +Each active truth file should answer one primary question. + +If a file tries to answer two questions at once, it becomes narrative sludge. + +## Target Truth Surface + +### Final hierarchy + +The truth surface should converge on the following hierarchy: + +- **Authoritative active queue:** one file only +- **Evidence source:** detailed rebuild audit evidence +- **Architecture boundary note:** broader conceptual risk and boundary note +- **Historical readiness residuals:** frozen residual files from the completed readiness cycle +- **Narrative ledger:** chronological record of what happened and why + +The active queue and the evidence source must never again be the same conceptual file. + +### 1. `project/current/ocr-v2-closeout-priority.md` + +Primary question: + +> What is the single active OCR queue right now? + +Required role after realignment: + +- become the short authoritative queue for current OCR work, +- explicitly state whether the active queue is branch-merge work, rebuild hardening, or another phase, +- link outward to broader notes and detailed audits. + +Recommended outcome: + +- either rename this role into a clearer active queue file such as `project/current/ocr-v2-active-queue.md`, +- or keep the filename temporarily but mark it explicitly as `ACTIVE QUEUE — post-readiness rebuild hardening` and treat the old closeout role as historical. + +Required change: + +- stop implying that “all gates done” means “nothing important remains,” +- replace merge-readiness-only framing with explicit branch state plus active post-gate queue. + +### 2. `project/current/ocr-v2-generalization-boundary.md` + +Primary question: + +> What architectural risks still matter conceptually, independent of today’s queue? + +Required role after realignment: + +- remain the broader architecture note, +- describe what the backbone solved and what classes remain sensitive, +- stop acting like the day-to-day execution queue. + +Required change: + +- add explicit language that the readiness-gate story is complete, +- frame rebuild hardening as a new surface layered on top of that completed story. + +### 3. `project/current/ocr-v2-remaining-issues-2026-06-18.md` + +Primary question: + +> What residuals remained at the end of the readiness-gate cycle? + +Required role after realignment: + +- freeze it as a readiness-cycle residual file, +- stop letting it pretend to be the active queue after the full rebuild audit. + +Required change: + +- clearly label it as readiness-cycle residuals, +- add a pointer to the new rebuild-audit remediation queue. + +### 4. `project/current/ocr_rebuild_audit.md` + +Primary question: + +> What did the full rebuild corpus audit find, and what remediation order does it imply? + +Required role after realignment: + +- become the detailed post-readiness rebuild hardening evidence source, +- own the problem inventory and fix priority for the rebuild surface, +- not pretend to redefine OCR-v2 architecture from scratch. + +Required change: + +- state explicitly that it is a post-readiness audit surface, +- avoid language that sounds like the readiness gates were fake or invalid. + +### 5. `PROJECT-MANAGEMENT.md` + +Primary question: + +> What happened, why, and what comes next? + +Required role after realignment: + +- record the narrative handoff clearly, +- make the transition from readiness completion to rebuild hardening explicit, +- identify which file now governs next execution. + +`PROJECT-MANAGEMENT.md` must not become the source of next execution tasks. When it conflicts with the active queue, the active queue wins. + +Required change: + +- add a dedicated transition section naming the new active queue, +- remove or overwrite wording that leaves “merge now” and “new major queue” standing side by side without explanation. + +## Required Narrative Contract + +After realignment, every active file should preserve the following contract: + +```text +OCR-v2 architecture readiness is complete. +Post-readiness rebuild hardening is now the active queue. +These are different evaluation surfaces, not contradictory truths. +``` + +If one active file violates this contract, the truth surface is not aligned. + +## Naming And Status Rules + +### Rule 1: Active queue files must say they are active + +If a file governs current work, its header must explicitly say so. + +### Rule 2: Historical residual files must say what cycle they belong to + +If a file describes residuals from a completed cycle, that status must be visible in the header. + +### Rule 3: Broader architecture notes must not double as execution queues + +Architecture notes may explain risk direction, but must not silently override the active queue. + +### Rule 4: Detailed audits must declare their evaluation surface + +`ocr_rebuild_audit.md` should explicitly say it is evaluating rebuild outputs across the corpus, not rejudging readiness-gate completion. + +## Required Realignment Actions + +### Action A: declare the active queue explicitly + +One current file must win as the active queue for OCR work after this design lands. + +Recommended winner: + +- `project/current/ocr-v2-closeout-priority.md` + +but with renamed framing if necessary so “closeout” does not mislead readers. + +Preferred end state: + +- `project/current/ocr-v2-active-queue.md` as the clean long-term queue name, +- or a clearly relabeled transitional queue if file churn must be minimized. + +### Action B: install explicit cross-links + +Each active truth file should link to: + +- the active queue, +- the broader architecture note, +- the rebuild audit if it is relevant, +- the historical residual file if it still matters for interpretation. + +The point is not more prose. The point is zero ambiguity about which layer a reader is on. + +### Action C: rewrite, do not merely append + +Where a prior statement is no longer the active truth, it should be rewritten, not just followed by a newer contradictory paragraph. + +This is especially important for: + +- merge-readiness language, +- “all gates done” language, +- “next work” sections. + +The editing rule is narrow: rewrite only the contradictory control-plane surfaces, not the underlying historical analysis bodies. + +### Action D: standardize OCR state vocabulary + +The truth surface should use a stable vocabulary set: + +- `readiness-gate complete` +- `post-readiness rebuild hardening` +- `active queue` +- `broader architecture note` +- `historical readiness residuals` + +Do not alternate casually between “close-out,” “done,” “remaining issues,” and “next work” without naming which surface is being discussed. + +## Contradiction Pass Checklist + +The implementation plan must include a contradiction pass over active truth files for phrases such as: + +- `merge now` +- `nothing remains` +- `all done` +- `final remaining` +- `active remaining issues` +- `readiness incomplete` +- `reopen architecture` + +For each hit, the reviewer must classify whether it is talking about: + +1. readiness-cycle status, +2. active rebuild-hardening queue, +3. historical analysis that should be preserved but clearly relabeled. + +No contradiction pass is complete if it only appends a new sentence without resolving the old conflicting one. + +## Acceptance Criteria + +This design is successful when all of the following are true: + +1. A new reader can understand in under five minutes that readiness completion and rebuild hardening are different truths. +2. Only one active file governs “what to do next.” +3. `PROJECT-MANAGEMENT.md` explains the handoff from readiness gates to rebuild hardening. +4. `ocr_rebuild_audit.md` is clearly framed as post-readiness evidence, not a repudiation of the OCR-v2 backbone. +5. The broader architecture note remains useful without pretending to be the active queue. +6. Historical residual files are clearly labeled as historical-cycle residuals. + +## Risks + +### Risk 1: leaving stale language in place + +If old “merge now” or “all done” wording stays beside new rebuild-hardening language, the design fails even if a new file exists. + +Mitigation: + +- rewrite active headers and “Next Work” sections directly. + +### Risk 2: inventing a third narrative layer + +Adding too many meta-files could make the truth surface worse. + +Mitigation: + +- prefer reassigning current files over creating new ones unless a new file is truly necessary. + +### Risk 3: treating documentation repair as cosmetic + +This is not cosmetic. It directly affects planning quality, agent handoff quality, and whether future work attacks the right surface. + +Mitigation: + +- define explicit acceptance criteria and one authoritative queue. + +## Execution Order + +The implementation plan for this design should proceed in this order: + +1. declare the vocabulary and active queue, +2. rewrite active-file headers and status sections, +3. relabel historical residual files, +4. align `PROJECT-MANAGEMENT.md` handoff language, +5. run a final contradiction pass across all active OCR truth files. + +## References + +- `PROJECT-MANAGEMENT.md` +- `project/current/ocr-v2-closeout-priority.md` +- `project/current/ocr-v2-generalization-boundary.md` +- `project/current/ocr-v2-remaining-issues-2026-06-18.md` +- `project/current/ocr_rebuild_audit.md` +- `docs/superpowers/specs/2026-06-18-ocr-v2-readiness-gates-design.md` diff --git a/docs/superpowers/specs/2026-06-20-reference-zone-and-ownership-hardening-design.md b/docs/superpowers/specs/2026-06-20-reference-zone-and-ownership-hardening-design.md new file mode 100644 index 00000000..fc875bf2 --- /dev/null +++ b/docs/superpowers/specs/2026-06-20-reference-zone-and-ownership-hardening-design.md @@ -0,0 +1,534 @@ +# Reference Zone And Ownership Hardening Design + +> Date: 2026-06-20 +> Status: draft for review +> Scope: add a shared layout-facts layer that hardens reference containment and figure/table ownership on untouched OCR papers + +## Goal + +Stabilize two remaining high-risk OCR surfaces without reopening the OCR-v2 backbone: + +1. keep the `reference_zone` practically complete while preventing non-reference intrusion, +2. keep figure/table ownership coherent on irregular display pages without reintroducing page-swallow behavior. + +The design adds one shared intermediate layer after structured blocks and before specialized consumers. That layer records page-level continuity and boundary facts. Reference logic then uses those facts to contain a reference corridor. Ownership logic uses those facts to grow and validate display clusters. + +The target is not perfect citation parsing or perfect object semantics. The target is stable containment: the right content stays together, and the wrong content stops leaking in. + +## Non-Goals + +This design does not: + +- redesign OCR-v2 role classification, +- replace the existing `zone` contract with a new semantic system, +- build a full bibliographic metadata parser, +- add free-form text rescue for role classification, +- use whole-page PDF text fallback to re-run reading order, +- replace figure/table matching with a new graph-based architecture. + +## Current Assessment + +Truth-audit results on untouched papers show that the main residual defects are now concentrated in two places. + +### 1. Reference containment is still too fragile on mixed pages + +Observed failure pattern: + +- references, body, and backmatter can share a page or spread, +- `reference_zone` continuation is too willing to over-extend across weakly separated content, +- `HOLD` states still create too much downstream contamination, +- explicit `References` headings or numbered entries are helpful when present, but cannot be assumed. + +The key point is that the system does not need citation-parser precision here. +It needs a practical corridor that keeps reference content together and keeps obvious non-reference content out. + +### 2. Ownership is still too brittle on irregular display layouts + +Observed failure pattern: + +- a large figure or table is visually one display unit, +- OCR inserts empty or weak `unknown_structural` gaps inside that display area, +- caption-to-asset pairing then breaks because local adjacency is too literal, +- current validation protects against dangerous page swallow, but recall is still weak on multi-panel or sparse layouts. + +The issue is not primarily caption scoring. The issue is that display continuity is under-modeled. + +## Design Principles + +### Principle 1: Shared layout facts come before specialized decisions + +Reference logic and ownership logic should not each rediscover page geometry from scratch. + +The pipeline should first compute lightweight page-level continuity facts, then let each downstream consumer apply its own acceptance rules. + +### Principle 2: Keep `zone` and strengthen it + +The existing `zone` work is valuable and should remain authoritative at the final surface. + +This design does not replace `zone`. It strengthens the evidence used to generate and validate `zone`, especially around: + +- mixed body/reference/tail pages, +- display-heavy pages, +- side inserts, +- empty bridge regions. + +### Principle 3: Reference logic optimizes for clean containment, not strict citation parsing + +For this pass, success means: + +- most real reference content remains in `reference_zone`, +- obvious non-reference content does not enter `reference_zone`, +- same-page transitions no longer cause large false spans, +- a small amount of citation-entry imperfection is acceptable. + +The design should therefore be wide enough to preserve reference continuity, but strict enough to block body/backmatter/display intrusion. + +### Principle 4: Ownership is cluster-first, not nearest-caption-first + +Figures and tables on complex pages should first be understood as display clusters. + +Only after cluster construction should a caption try to own a primary asset or grouped asset set. + +### Principle 5: Text is controlled evidence only + +Allowed text use in this design: + +- reference family/style detection after reference candidacy already exists, +- journal-abbreviation matching as a supporting reference signal, +- controlled number/marker extraction after structural candidacy exists, +- local PDF text fallback for hard reference-entry repair inside an already accepted reference corridor. + +Disallowed text use: + +- phrase-based semantic role rescue, +- publisher-wording rules for deciding section meaning, +- global PDF text reordering, +- prose-content matching as the primary basis for ownership. + +## Core Design + +## 1. Shared Layout-Facts Layer + +After structured blocks are built and normalized, compute a lightweight layout-facts layer. + +This layer should not emit final semantic judgments. It should emit page-level continuity facts. + +### Required facts per block + +At minimum: + +- `reading_band_id` +- `display_cluster_candidate_id` +- `layout_region` +- `boundary_before` +- `boundary_after` +- `bridge_eligible` + +### Meaning of each field + +#### `reading_band_id` + +Identifies a locally continuous reading stream. + +Purpose: + +- helps reference continuation stay inside an explainable local flow, +- helps same-page mixed content avoid accidental cross-column or cross-region swallowing. + +#### `layout_region` + +Coarse page-function region only: + +- `body_flow` +- `display_zone` +- `side_insert` +- `tail_candidate` +- `reference_candidate` + +This is not a replacement for final role. It is a page-function hint. + +#### `boundary_before` and `boundary_after` + +Minimal contract: + +- `none` +- `weak` +- `hard` + +This captures whether reading flow likely changes at a block edge. + +Examples of hard-boundary triggers: + +- a strong section/backmatter heading, +- a clear transition from dense short reference-like blocks to prose, +- a display cluster start that interrupts reading flow. + +#### `bridge_eligible` + +Boolean. + +Marks a weak or empty structural block that is allowed to act as a display-continuity bridge. + +Purpose: + +- prevents large display objects from being artificially split by empty OCR gaps, +- must not by itself force ownership. + +## 2. Reference Corridor Hardening + +Reference handling should be redesigned as a corridor-containment problem. + +The system does not need a strict heading-driven `ref-start` model. It needs a way to decide whether a local run of blocks is stable enough to remain in `reference_zone` without admitting intrusions. + +### 2.1 Candidate selection stays broad + +Reference candidacy may come from several weak-to-strong signals: + +- `raw_role` or `raw_label` reference signals, +- `layout_region == reference_candidate`, +- tail-position priors, +- short-block density, +- local reference-style evidence. + +No single cue is mandatory. + +This is important because untouched papers may have: + +- no explicit `References` heading, +- no numbering, +- heavily split entries, +- continuation pages with no clean restart cue. + +### 2.2 Final decision is practical containment + +Two separate scores should be computed. + +#### `ref_membership_score` + +How much the block or reconstructed entry looks like reference content. + +#### `non_ref_intrusion_score` + +How much the block looks like content that should not enter the reference corridor. + +Examples of strong intrusion evidence: + +- body-style paragraph recovery, +- `Acknowledgements`, `Funding`, `Conflict of Interest`, `Data availability`, +- display captions or object inserts, +- a new section/subsection heading, +- strong side-insert structure. + +The decision should optimize for: + +- keeping reference-like content inside the corridor, +- stopping when intrusion evidence becomes strong. + +### 2.3 Reference family/style detection is a validator + +Reference format detection should support corridor stability, not dominate it. + +The detector should assign a coarse family to a block or reconstructed entry: + +- `vancouver_structured_numbered` +- `vancouver_structured_unnumbered` +- `author_year` +- `book_or_report` +- `unknown` + +This family signal is used to answer: + +- does this local run look style-consistent, +- does the run continue the same reference rhythm, +- did a likely prose/body segment interrupt the run. + +The system must not require every reference entry to classify perfectly before allowing a stable `reference_zone`. + +### 2.4 Journal-abbreviation support is strong positive evidence + +A compact biomedical journal lexicon should be introduced using NLM-style journal abbreviations. + +This lexicon should support: + +- exact normalized abbreviation match, +- token-subsequence match for lightly degraded OCR, +- optional conservative fuzzy token match only inside high-confidence reference candidates. + +This signal improves detection of biomedical journal references, especially unnumbered Vancouver-like entries. + +It must remain optional support. +Failure to match the lexicon must not force a block out of the reference corridor. + +### 2.5 Entry reconstruction is local and pragmatic + +Because OCR often splits one citation across multiple blocks, the system should form local `reference entry candidates` inside a high-confidence corridor. + +Blocks should be merged only when: + +- they are local near-neighbors, +- the gap is small, +- the merged text raises reference-family confidence, +- intrusion evidence does not rise. + +The goal is not full citation parsing. +The goal is to prevent corridor fragmentation caused by OCR splitting. + +### 2.6 PDF text fallback is local repair only + +If a local reference entry candidate remains badly fragmented, the system may use PDF text fallback. + +This is allowed only when all of the following are true: + +- the block run already sits in a high-confidence reference corridor, +- the current OCR blocks are too fragmented to sustain continuity, +- fallback is limited to a small local page window near the current block run, +- the result is used only to improve local style/continuity judgment. + +It must not: + +- re-run page reading order, +- rewrite the whole corridor from raw PDF text, +- become the primary reference detector. + +### 2.7 HOLD must stop contaminating final membership + +`HOLD` should remain a diagnostic state, not a final-membership contaminant. + +If a corridor is not good enough for acceptance, it should: + +- remain a candidate for audit/debugging, +- avoid converting large downstream surfaces into accepted reference content. + +## 3. Ownership Hardening Through Display Clusters + +Ownership should be rewritten as a display-cluster problem rather than a nearest-neighbor caption problem. + +### 3.1 Build display clusters before ownership + +For figure and table surfaces, first form a display cluster from: + +- assets, +- caption blocks, +- inner display text, +- bridge-eligible weak/empty blocks that connect visually continuous display regions. + +This cluster stage does not yet force caption ownership. + +### 3.2 `bridge_eligible` exists to preserve visual continuity + +Some `unknown_structural` or near-empty blocks are not semantic content, but they still occupy the display field between caption and asset. + +These blocks should be allowed as continuity bridges when: + +- they sit between display components, +- they do not show strong body-flow evidence, +- the surrounding geometry strongly supports one display unit. + +This prevents false fragmentation on: + +- large multi-panel figures, +- wide figures with right-column empty gaps, +- sparse table/figure layouts. + +### 3.3 Ownership becomes cluster-first + +Caption ownership should follow this sequence: + +1. identify the best candidate display cluster, +2. validate that the cluster is locally coherent, +3. decide whether the caption owns a primary asset or grouped asset set, +4. demote to grouped evidence or ambiguity if validation fails. + +This design keeps the current anti-page-swallow safety goal intact. + +### 3.4 Ownership validation remains hard + +After a display cluster is formed, validate it before strict ownership. + +Validation checks should include: + +- whether the cluster crosses another caption control region, +- whether the cluster became too large without internal support, +- whether body-flow or side-insert evidence interrupts the cluster, +- whether another narrower cluster explains the caption better. + +If validation fails, the system should prefer: + +- `grouped_evidence_only`, +- split, +- or ambiguity, + +instead of forcing a strict match. + +## Detectable Reference Features + +The reference detector should extract weak features at block level, then aggregate them. + +### Block-level reference features + +- `lead_marker_signature` +- `author_signature` +- `year_signature` +- `journal_signature` +- `volume_issue_pages_signature` +- `online_marker_signature` +- `book_report_signature` +- `surface_style_signature` +- `journal_lexicon_match` + +These should not individually decide final membership. + +### Run-level continuity features + +- local family consistency, +- punctuation rhythm consistency, +- density of short reference-like blocks, +- continuation across neighboring reading bands when the layout strongly supports it, +- conflict with hard boundaries. + +## Required Contracts + +## Layout-facts contract + +At minimum one shared surface should expose enough information for both consumers to reason about continuity without redoing page geometry. + +Acceptable implementations: + +- add fields to structured blocks, +- or write a parallel `layout_segments.json` plus structured-block annotations. + +The first pass should prefer the smaller diff. + +## Reference decision contract + +At minimum reference processing should expose: + +- `ref_membership_score` +- `non_ref_intrusion_score` +- `reference_style_family` +- `reference_style_confidence` +- `reference_continuity_state` +- accepted vs candidate reference membership outcome + +The system does not need to expose a full parsed bibliography model in this pass. + +## Ownership contract + +At minimum figure/table ownership candidates should expose: + +- `display_cluster_id` +- `cluster_block_ids` +- `cluster_bbox` +- `bridge_block_ids` +- `ownership_validation_status` +- `ownership_validation_reason` + +This is for auditability and debugging, not for user-facing verbosity. + +## File Responsibilities + +### `paperforge/worker/ocr_document.py` or nearest shared layout module + +Owns: + +- computation of layout facts that are shared across consumers, +- reading-band continuity, +- coarse layout-region assignment, +- hard/weak boundary detection, +- bridge-eligibility hints. + +The exact file can follow the cleanest existing structure, but the responsibilities should remain centralized. + +### Reference consumer module(s) + +Likely `paperforge.worker` logic near current structural gate / reference-zone handling should own: + +- reference candidate selection, +- family/style detection, +- journal-lexicon support, +- local entry reconstruction, +- local PDF text fallback, +- final reference-zone acceptance vs HOLD. + +### `paperforge/worker/ocr_figures.py` and `paperforge/worker/ocr_tables.py` + +Own: + +- display-cluster construction, +- bridge-aware cluster growth, +- cluster-first caption ownership, +- validation before strict ownership. + +### Render and health surfaces + +Must consume accepted outcomes only. + +They should not become rescue layers for weak segmentation or weak ownership. + +## Acceptance Criteria + +This design is successful when all of the following are true: + +1. Untouched high-risk papers show fewer `reference_span_error` findings. +2. Same-page body/reference/tail mixes stop swallowing obvious non-reference content into `reference_zone`. +3. Reference handling remains practically complete even when entries are unnumbered or heading-free. +4. Untouched display-heavy papers show fewer `object_ownership_error` findings. +5. Large multi-panel displays no longer fragment just because weak empty blocks sit inside the display field. +6. No return to page-swallow ownership behavior occurs. +7. PDF fallback remains local and does not become a hidden global reordering system. + +## Validation Strategy + +Validate on both protected and untouched papers. + +### Reference validation + +Use: + +1. existing gold/regression papers that already exercise reference-tail behavior, +2. untouched high-risk audit papers with same-page boundary failures, +3. untouched papers with unnumbered or heading-free reference regions when available. + +Primary check: + +- is the reference corridor practically complete, +- are obvious non-reference intrusions gone. + +### Ownership validation + +Use: + +1. existing protected figure/table regressions, +2. untouched multi-panel and display-sparse papers, +3. pages where empty or weak structural gaps currently split one visual object. + +Primary check: + +- is ownership more coherent, +- are ambiguity and unmatched-asset counts reduced, +- has safety against page swallow remained intact. + +## Recommended Execution Order + +To keep the first pass small and high value, implement in this order: + +1. shared layout-facts layer, +2. reference anti-intrusion corridor hardening, +3. display-cluster and bridge-aware ownership hardening, +4. journal-abbreviation lexicon support, +5. local reference-entry reconstruction, +6. local PDF text fallback for hard reference entry repair. + +This order improves containment before adding refinement layers. + +## References + +- `docs/superpowers/specs/2026-06-19-ocr-rebuild-audit-remediation-design.md` +- `docs/superpowers/specs/2026-06-20-region-growing-figure-merge-design.md` +- `docs/superpowers/specs/2026-06-20-table-note-stabilization-design.md` +- `project/current/ocr_rebuild_audit.md` +- `audit/KIX7SKXQ/audit_report.json` +- `audit/GTRPMM56/audit_report.json` +- `https://www.icmje.org/recommendations/` +- `https://www.nlm.nih.gov/bsd/uniform_requirements.html` +- `https://www.ncbi.nlm.nih.gov/nlmcatalog/journals/` diff --git a/docs/superpowers/specs/2026-06-20-region-growing-figure-merge-design.md b/docs/superpowers/specs/2026-06-20-region-growing-figure-merge-design.md new file mode 100644 index 00000000..b5fabbf4 --- /dev/null +++ b/docs/superpowers/specs/2026-06-20-region-growing-figure-merge-design.md @@ -0,0 +1,200 @@ +# Region-Growing Figure Merge Design + +> Date: 2026-06-20 +> Status: draft for review +> Scope: replace fragile row-first multi-panel grouping assumptions with region-growing figure merge plus validation + +## Goal + +Make figure grouping less dependent on neat layouts. + +This design introduces a region-growing merge model that starts from a seed asset and gradually expands to nearby assets, then validates the merged group before it can become strict figure ownership. + +The aim is to improve multi-panel and irregular figure grouping without reintroducing page-swallow behavior. + +## Non-Goals + +This design does not: + +- redesign table matching, +- add free-form text-based figure rescue, +- trust whole-page asset grouping as a default, +- replace downstream reader/render contracts unnecessarily. + +## Current Assessment + +The first grouping hardening pass solved the most dangerous failure: `page_assets` can no longer casually swallow a page. + +That made grouping safe enough, but not fully strong enough. + +Current limitations remain: + +- row-first pair/triple assumptions still dominate, +- irregular 2x2 or stacked layouts are under-modeled, +- a merged group is still often compressed into one coarse `cluster_bbox`, +- grouping confidence and ownership validation are too tightly coupled. + +The result is that grouping no longer explodes, but it still leaves ownership recall on the table. + +## Hard Constraint: Validation After Growth + +The system must not trust a grown group just because its assets are locally adjacent. + +Grouping is a candidate-generation phase. +Strict ownership requires a later validation phase. + +If validation fails, the system should: + +- split back to smaller candidates, +- demote the group to grouped evidence only, +- or leave the legend ambiguous. + +It must not force a strict match from a weak merged group. + +## Core Design + +### 1. Seed from the upper-left asset on each page region + +Grouping should begin from the earliest plausible figure asset in page reading order, typically the top-left asset. + +This does not mean “the entire page is one figure.” +It means candidate groups start from a concrete seed and grow locally. + +### 2. Grow only through local adjacency + +From each seed, test adjacent assets one step at a time. + +Local adjacency should consider: + +- right-neighbor proximity, +- below-neighbor proximity, +- shared boundary bands, +- relative size compatibility, +- gaps that are large in absolute pixels but still small relative to the panels involved. + +After absorbing one asset, recompute the active group geometry and continue growing from that updated boundary. + +This produces an explicit growth path rather than one-shot row guessing. + +### 3. Keep merge evidence per absorbed asset + +Each absorbed asset should record why it was merged, for example: + +- `adjacent_right` +- `adjacent_below` +- `shared_band` +- `gap_tolerated_by_size_ratio` +- `aligned_stack` + +This evidence should survive into debugging surfaces. + +The purpose is to make grouping auditable instead of opaque. + +### 4. Validate the grown group against control boundaries + +Once a group is grown, validate it before strict ownership. + +Validation checks should include: + +- does the group cross another caption’s likely control zone, +- is the inter-panel gap too large without supporting evidence, +- is the group spanning two visually separate figures, +- is a narrower local group better explained than the larger one, +- does the legend-caption geometry still make sense against the grown group. + +If the answer is no, the system should demote or split. + +### 5. Keep page-level priors as guardrails, not primary merge logic + +Page-level context remains useful as a guardrail: + +- where captions cluster, +- where display zones exist, +- where references or backmatter begin. + +But page priors should not decide the group directly. +They should only constrain growth and validation. + +## Required Contracts + +### Candidate group contract + +Each figure candidate group should carry: + +- `seed_asset_block_id` +- `asset_block_ids` +- `growth_steps` +- `group_bbox` +- `growth_evidence` +- `validation_status` +- `validation_reason` + +`growth_steps` should be a compact sequence, not a huge trace dump. + +### Validation status contract + +At minimum: + +- `strict_match_ok` +- `grouped_evidence_only` +- `split_required` +- `ambiguous` + +This separates “candidate group exists” from “candidate group is safe to own a legend.” + +## File Responsibilities + +### `paperforge/worker/ocr_figures.py` + +Owns: + +- seed selection, +- local adjacency growth, +- candidate-group evidence, +- post-growth validation, +- demotion or split when validation fails. + +### `tests/test_ocr_figures.py` + +Should grow to cover: + +- irregular side-by-side pairs, +- stacked layouts, +- 2x2-like growth, +- large but still acceptable gaps, +- false merges that validation must reject. + +### `tests/test_ocr_real_paper_regressions.py` + +Should protect: + +- no return to page-swallow behavior, +- no regression on already-stable gold papers, +- at least one irregular-layout real-paper case. + +## Acceptance Criteria + +This design is successful when all of the following are true: + +1. Figure grouping no longer depends primarily on row-first neat-layout assumptions. +2. A group can be grown gradually from a seed asset through local adjacency. +3. Large-but-plausible gaps can be tolerated when supported by relative geometry. +4. Suspicious merges are demoted or split rather than forced into strict ownership. +5. No return to unrestricted `page_assets` behavior occurs. + +## Validation Strategy + +Validate on: + +1. known residual figure-ownership papers, +2. fresh unseen papers with mixed multi-panel layouts, +3. the existing no-page-swallow regression set. + +Success means not only better match recall, but no new failure family introduced on the unseen sample. + +## References + +- `docs/superpowers/specs/2026-06-19-ocr-rebuild-audit-remediation-design.md` +- `project/current/ocr-v2-generalization-boundary.md` +- `project/current/ocr_rebuild_audit.md` +- `paperforge/worker/ocr_figures.py` diff --git a/docs/superpowers/specs/2026-06-20-table-note-stabilization-design.md b/docs/superpowers/specs/2026-06-20-table-note-stabilization-design.md new file mode 100644 index 00000000..8cd8cd82 --- /dev/null +++ b/docs/superpowers/specs/2026-06-20-table-note-stabilization-design.md @@ -0,0 +1,219 @@ +# Table Note Stabilization Design + +> Date: 2026-06-20 +> Status: draft for review +> Scope: stabilize table-note ownership and continue table ambiguity reduction without reopening OCR-v2 role classification + +## Goal + +Make table notes a stable post-ownership surface. + +This design has two linked goals: + +1. separate table notes from body prose and page-footnote regions more reliably, +2. improve bare `Table N` matching using stronger layout tie-breaks rather than free-form text rescue. + +The intent is to deepen the table-local ownership contract now that rebuild-output pollution, namespace collisions, and basic table-note write-through are already fixed. + +## Non-Goals + +This design does not: + +- redesign OCR role classification, +- add publisher-specific text rules, +- solve figure ownership, +- change the global OCR-v2 readiness conclusion, +- replace the existing table matching scorer wholesale. + +## Current Assessment + +The first remediation pass already proved three things: + +1. table notes can be carried through inventory, object markdown, and fulltext projection, +2. blockquote table-caption pollution is gone, +3. bare `Table N` captions no longer have to be rejected immediately. + +The remaining problem is stability. + +Current residuals show two failure modes: + +- a table note can still be confused with page footnotes or nearby body text, +- a bare `Table N` caption can still remain ambiguous when multiple plausible table assets compete. + +Those are not text-understanding failures. They are layout-ownership failures. + +## Hard Constraint: No Free-Form Text Rescue + +This design keeps the same contract as the previous remediation spec. + +Allowed text use: + +- controlled marker extraction after structural candidacy already exists, +- note text formatting after note ownership is already decided, +- optional weak note-marker support (`*`, `†`, `a`, `b`, `Abbreviation:`) only as secondary evidence. + +Disallowed text use: + +- deciding semantic role from prose content, +- using publisher wording to identify notes, +- using table-note wording as the primary ownership signal. + +Layout, ownership, and document priors must dominate text. + +## Core Design + +### 1. Page footnote prior comes before table-local note ownership + +When a table sits near the bottom of a page, the main risk is confusing page footnotes with table notes. + +The design must therefore build a `page_footnote_prior` from other pages in the same paper before deciding local table-note ownership. + +This prior should summarize: + +- where page footnotes tend to begin on the page, +- how close they sit to the page bottom, +- whether they span a full column / footer band, +- whether they are repeatedly present across the paper in a similar zone. + +If a candidate note block on the current page falls into a strong page-footnote zone, it should default toward page footnote rather than table note unless table-local evidence is substantially stronger. + +### 2. Table notes should be recognized as a note band, not isolated blocks + +Single-block note decisions are too brittle. + +After a table asset is matched, the system should build a `table_below_note_band` by scanning directly below the table and grouping nearby small text blocks that: + +- are vertically near the table bottom, +- overlap the table horizontally, +- share smaller typography or tighter line spacing than body prose, +- remain separated from the next body paragraph by a whitespace band. + +This band can contain one or more note blocks. Ownership should attach to the band first, then to its member blocks. + +### 3. Body exclusion is a first-class signal + +The system should not only ask “does this look like a table note?” + +It should also ask: + +- does this look like continuation of body flow, +- does it align with body spine width, +- is there insufficient whitespace separation from body prose below, +- is it too wide / too long / too regular to plausibly be a note band? + +If body evidence is stronger than note-band evidence, the candidate should remain body text. + +### 4. Bare `Table N` should use a stronger spatial tie-break, not a broader caption rule + +The current improvement allowed bare `Table N` to enter competition. The next step is not more permissive caption detection. + +The next step is a stronger tie-break among already-accepted table candidates. + +Priority signals: + +- stronger x overlap with the candidate asset, +- shorter table-caption-to-asset vertical distance, +- same-column preference when multiple candidates exist, +- stronger advantage over second-best candidate, +- continuation-page handling evaluated separately from same-page matching. + +This should improve `matched` / `matched_low_confidence` rates without weakening the role contract. + +## Required Contracts + +### Table note ownership contract + +The table inventory surface should carry, at minimum: + +- `note_block_ids` +- `note_texts` +- `note_bboxes` +- `note_band_bbox` +- `note_match_reason` +- `note_confidence` +- `consumed_block_ids` + +`note_match_reason` should capture why the band was attached, for example: + +- `footnote_role_below_table` +- `vision_footnote_below_table` +- `note_band_geometry_match` +- `page_footnote_prior_rejected` + +This is for auditability, not verbosity. + +### Page footnote prior contract + +The page-footnote prior should be explicit enough to answer: + +- why a candidate was rejected as a table note, +- whether the rejection came from page-bottom prior or body-flow prior, +- whether the page had no prior and therefore local geometry dominated. + +### Table ambiguity contract + +Bare `Table N` should now resolve to one of: + +- `matched` +- `matched_low_confidence` +- `ambiguous` +- `unmatched` + +but only after candidate competition is run. It must no longer be a purely pre-score rejection path. + +## File Responsibilities + +### `paperforge/worker/ocr_tables.py` + +Owns: + +- page-footnote prior derivation for table-note decisions, +- note-band grouping below matched tables, +- note ownership write-through, +- table ambiguity tie-breaks among accepted candidate assets. + +### `paperforge/worker/ocr_objects.py` + +Owns: + +- projection of owned note bands into table object markdown. + +### `paperforge/worker/ocr_render.py` + +Owns: + +- suppression of consumed note blocks from body flow, +- no fresh semantic reclassification. + +### `paperforge/worker/ocr_health.py` + +Owns: + +- additive reporting about note-band ownership and table ambiguity only if useful for auditability. + +## Acceptance Criteria + +This design is successful when all of the following are true: + +1. A table at page bottom no longer greedily captures page footnotes just because text is below the table. +2. Multi-line note bands directly below tables are attached more reliably than single-block note heuristics. +3. Table notes are less likely to be confused with body prose because whitespace and body-width exclusion are explicit. +4. Bare `Table N` captions improve through stronger spatial tie-breaks rather than freer caption admission. +5. No new free-form text rescue path is introduced. + +## Validation Strategy + +This work should be validated on two sample sets: + +1. known residual papers where table ambiguity or note ownership is already visible, +2. a fresh sample of papers that were not manually optimized beforehand. + +The point is to verify both local improvement and absence of new failure families. + +## References + +- `docs/superpowers/specs/2026-06-19-ocr-rebuild-audit-remediation-design.md` +- `project/current/ocr_rebuild_audit.md` +- `paperforge/worker/ocr_tables.py` +- `paperforge/worker/ocr_objects.py` +- `paperforge/worker/ocr_render.py` diff --git a/docs/superpowers/specs/2026-06-21-global-distance-clustering-figure-merge.md b/docs/superpowers/specs/2026-06-21-global-distance-clustering-figure-merge.md index 0909e690..e2ac4e69 100644 --- a/docs/superpowers/specs/2026-06-21-global-distance-clustering-figure-merge.md +++ b/docs/superpowers/specs/2026-06-21-global-distance-clustering-figure-merge.md @@ -1,239 +1,145 @@ # Global Distance Clustering for Figure Merge > **Date:** 2026-06-21 -> **Status:** draft for review -> **Scope:** Replace greedy region-growing figure merge with global distance-based clustering + caption-as-boundary fallback +> **Status:** v3 — revised after 2nd GPT review +> **Scope:** Replace greedy region-growing figure merge with caption-band-constrained pairwise distance clustering + group-aware sequential fallback > **Supersedes:** `2026-06-20-region-growing-figure-merge-design.md` --- ## 1. Why region-growing failed -The 2026-06-20 spec introduced `_grow_region_from_seed`: starting from one asset, greedily absorb neighbors right and down. It was extended to 4 directions (left, up, right, down) but the core problem remains: +The 2026-06-20 spec introduced `_grow_region_from_seed`: greedy seed expansion in 2→4 directions. Still fails because: | Problem | Why | Consequence | |---------|-----|-------------| -| **First seed wins** | Assets are sorted y-x; the top-left seed absorbs everything it can reach | Remaining seeds get fewer assets → partial merges | -| **No backtracking** | Once absorbed, an asset is `seen_growth_ids` and can't join another group | Wrong merges persist | -| **Overlapping candidates** | An asset exists in single_asset + same_row + region_grown groups simultaneously | Groups compete via scoring; the closest asset wins, merged group loses | -| **Local greed, not global view** | Each seed only sees immediate neighbors, not the whole page layout | 2x2 grids, irregular layouts, and cross-column figures all fail | - -**Concrete failure (SAN9AYVR Figure 23, page 50):** -A large multi-panel figure with panels a-h spanning the page. Region growth from the top-left seed absorbs some panels, eats across the page, but misses panels in the lower-right because they're more than one "gap" away from any grown boundary. Those missed panels become unmatched assets. +| **First seed wins** | Assets sorted y-x; top-left seed absorbs everything reachable | Remaining seeds get fewer assets → partial merges | +| **No backtracking** | Absorbed asset is `seen_growth_ids`, can't rejoin | Wrong merges persist | +| **Overlapping candidates** | One asset in single_asset + same_row + region_grown simultaneously | Groups compete by scoring; closest wins, merged loses | +| **Local greed** | Each seed only sees neighbors, not whole page | 2x2 grids, irregular layouts fail | --- -## 2. Design: distance-based clustering +## 2. Design: global distance clustering + caption band partition + group-aware fallback ### Core principle -On a given page, ASSETS THAT ARE CLOSE TOGETHER WITH NO TEXT SEPARATOR BETWEEN THEM FORM ONE FIGURE. +1. **Global pairwise clustering** replaces greedy seed-growth. Union-find on all pairwise distances within a caption band produces globally optimal clusters. +2. **Caption bands partition the page BEFORE clustering** on multi-legend pages. Assets in different bands can NEVER be in the same cluster. +3. **One candidate group per asset** — no overlapping candidates, no competition between single_asset and merged group. +4. **Group-aware sequential fallback** allows unmatched distance_clusters to be consumed as whole groups, not asset-by-asset. -This is how human vision works: global spatial proximity + text boundaries = perceptual groups. +### Implementation contract -### Algorithm (8 steps) +```text +1. Extract _filter_figure_assets() from current compatible asset filtering: + figure_asset: accept. + media_asset: accept if raw_label in {image, chart, figure}, + or raw_label empty, + or raw_label == "table" AND "= 2: + partition assets using _partition_assets_by_caption_bands(). + cluster independently inside each band. + else: + cluster all page assets together. -Step 3 — Pairwise distance clustering - For each pair of assets (A, B) on the same page: - - horizontal_gap = max(0, left_b - right_a) [right edge of leftmost to left edge of rightmost] - - vertical_gap = max(0, top_b - bottom_a) [bottom of upper to top of lower] - - candidate_for_merge = true IF: - horizontal_gap <= max(page_width * 0.12, 40) - AND vertical_gap <= max(page_height * 0.08, 40) - - BUT: if a text block (body_paragraph, section_heading, subsection_heading) - with non-empty text exists in the bounding rectangle between A and B, - candidate_for_merge = false (text separator) +4. _cluster_page_assets(): + pairwise union by h_gap/v_gap/no_text_separator. + irregular merge across clusters only when ALL of: + n_legends <= 1 + y_overlap / shorter_h >= 0.5 + horizontal_gap <= page_width * 0.25 + no text separator between clusters. - Union-find: connect all candidate pairs into clusters. +5. Group type: + len(cluster) >= 2 => distance_cluster + len(cluster) == 1 => single_asset + Each group entry carries: + caption_band_id: which caption band it belongs to (or None) + page_legend_count: total legends on this page + page_cluster_count: total groups of all types on this page + safe_auto_match: len(page_legends)==1 AND page_cluster_count==1 AND len(cluster)>=2 -Step 4 — Irregular layout merge - For each pair of clusters (C1, C2): - y_overlap = overlap of C1's y-range and C2's y-range - shorter_height = min(height of C1, height of C2) - if y_overlap >= shorter_height * 0.5: - merge C1 and C2 even if horizontal_gap exceeds threshold - (Rationale: 1 tall left panel + 3 small right panels form one figure) +6. _score_legend_to_group(): + single_asset: current score_figure_match (unchanged). + distance_cluster: + if group.safe_auto_match: return {"score": 0.85, "decision": "matched"} + else: score_figure_match(cluster_bbox) + 0.15 bounded multi-asset bonus. -Step 5 — Generate candidate groups - Each cluster → ONE candidate group entry - cluster_bbox = union of all asset bboxes in the cluster - group_type = "distance_cluster" - evidence = ["same_page", "distance_clustered"] - -Step 6 — Count legends on the page - legends = blocks with role=figure_caption on this page - n_legends = len(legends) - -Step 7 — Match legends to clusters - Case n_legends == 0: - → orphan clusters, pass to _expand_matched_assets_locally (existing cross-page fallback) - Case n_legends == 1: - → auto-match legend to cluster. score = 0.85. decision = "matched" - No scoring competition. - Case n_legends >= 2: - → split: sort legends by y-position. Sort clusters by y-position. - Assign each cluster to the nearest legend. - If multiple clusters map to the same legend → merge them. - If any legend has no cluster → pass to single_asset fallback. - -Step 8 — Single assets not in any cluster - → treated as individual candidate groups (backward compatible) - → matched via existing score_figure_match -``` - -### Threshold rationale - -The gap thresholds (12% page width, 8% page height, min 40px) match the existing thresholds used in `same_row_pair` and `_grow_region_from_seed`. They've been tested on 37 normal papers without false page-swallow. No new threshold tuning needed. - -The min 40px floor prevents over-merging on small figures in dense layouts. - -### Text separator detection - -```python -def _has_text_separator(a: dict, b: dict, all_blocks: list[dict]) -> bool: - """Check if any text block exists in the bounding rect between assets a and b.""" - ax1, ay1, ax2, ay2 = a["bbox"] - bx1, by1, bx2, by2 = b["bbox"] - # bounding rect of both assets - rect = [min(ax1, bx1), min(ay1, by1), max(ax2, bx2), max(ay2, by2)] - for block in all_blocks: - role = block.get("role", "") - if role not in ("body_paragraph", "section_heading", "subsection_heading"): - continue - txt = str(block.get("text", "") or "").strip() - if not txt: - continue - bx1, by1, bx2, by2 = block["bbox"] - # text block INSIDE the bounding rect AND BETWEEN the two assets vertically - if (bx1 > rect[0] and bx2 < rect[2] and - by1 > min(ay2, by2) and by2 < max(ay1, by1)): - return True - return False +7. Fallback: + Keep _expand_matched_assets_locally unchanged (same-page only, legend-required). + Add GROUP-AWARE sequential fallback: + - unmatched_candidate_groups includes distance_clusters not consumed by any same-page legend. + - Sequential fallback takes the next available group (all its assets together), + not individual assets. + - Old single-asset sequential fallback remains as last resort. + Track used_group_ids so each group is consumed at most once. ``` --- -## 3. Edge-case matrix with fallbacks +## 3. Algorithm details -All 10 scenarios from the PROJECT-MANAGEMENT analysis, with concrete handling: - -| # | Scenario | Detection | Handling | Fallback | -|---|----------|-----------|----------|----------| -| 1 | One page, 2+ separate figures | n_legends >= 2 | Split by y-proximity | Per-asset single_agent scoring | -| 2 | Cross-page figure | n_legends == 0 after per-page clustering | Move to `_expand_matched_assets_locally` | Existing sequential fallback | -| 3 | Dense old-journal layout | Text separator in gap | Don't merge across separator | Tight spacing with no text → distance threshold allows merge | -| 4 | Irregular layout (1 tall + 3 small) | y_overlap >= 50 | Force merge across x-gap | If over-merged, caption-as-boundary splits | -| 5 | Embedded caption inside figure | Caption is not an asset | Ignored by clustering | N/A | -| 6 | Figure + table on same page | Split by type (figure_asset vs table_asset) | Cluster separately | Type-independent position fallback | -| 7 | Multi-column figures same y | n_legends >= 2 | Caption-as-boundary split | Single_asset fallback | -| 8 | Orphan single-panel figure | Cluster of size 1 | Standalone candidate | Existing score_figure_match | -| 9 | Text-separated figures | Text separator exists | Don't merge across | Distance threshold without separator | -| 10 | Very large multi-panel (>10 panels) | Many assets, single legend | Cluster merges all; sequential expansion collects stragglers | Existing `_expand_matched_assets_locally` | - ---- - -## 4. Files to change - -### `paperforge/worker/ocr_figures.py` - -| Function | Lines | Change | -|----------|-------|--------| -| `_build_candidate_figure_groups_from_assets` | 487-603 | Replace entire body. Remove single_asset, same_row, page_assets, region_growth. Add clustering. | -| `_grow_region_from_seed` | 361-389 | DELETE (replaced by clustering) | -| `_validate_grown_region` | 392-413 | DELETE (validation moves into clustering) | -| `_asset_gap_left` | (new) | DELETE (added in previous fix, no longer needed) | -| `_asset_gap_above` | (new) | DELETE (no longer needed) | -| `_score_legend_to_group` | 608-662 | MODIFY: add `"distance_cluster"` case returning score=0.85, `decision="matched"` when n_legends==1 | -| `_expand_matched_assets_locally` | 665-? | No change (cross-page fallback stays) | -| NEW `_cluster_page_assets` | (new) | ADD: main clustering function | -| NEW `_has_text_separator` | (new) | ADD: text separator detection | - -### `paperforge/worker/ocr_figures.py` — detailed function changes - -**`_build_candidate_figure_groups_from_assets()`** — replacement: +### 3.1 Asset filter (`_filter_figure_assets`) ```python -def _build_candidate_figure_groups_from_assets( - assets: list[dict], blocks: list[dict], - legends: list[dict], page_width: float = 1200 -) -> list[dict]: - media = _filter_figure_assets(assets) - groups: list[dict] = [] - next_id = 1 - - by_page: dict[int, list[dict]] = {} - for block in media: - by_page.setdefault(int(block.get("page", 0) or 0), []).append(block) - - for page, page_media in by_page.items(): - if len(page_media) == 0: +def _filter_figure_assets(assets: list[dict]) -> list[dict]: + """Extract figure-like media blocks with backward compatibility.""" + result = [] + for b in assets: + if b.get("_non_body_media"): continue - - # Count legends on this page - page_legends = [l for l in legends if l.get("page") == page] - - # Cluster assets by distance - clusters = _cluster_page_assets(page_media, blocks, page_width) - - for cluster in clusters: - entry = _candidate_group_entry( - f"group_{next_id:04d}", page, cluster, - "distance_cluster", - ["same_page", "distance_clustered"], - ) - groups.append(entry) - next_id += 1 - - # Single assets not in any cluster → individual groups - clustered_ids = set() - for c in clusters: - for bid in [b.get("block_id") for b in c]: - clustered_ids.add(str(bid)) - for block in page_media: - if str(block.get("block_id", "")) not in clustered_ids: - groups.append(_candidate_group_entry( - f"group_{next_id:04d}", page, [block], - "single_asset", ["same_page", "single_asset"] - )) - next_id += 1 - - return groups + role = b.get("role", "") + if role == "figure_asset": + result.append(b) + elif role == "media_asset": + rl = str(b.get("raw_label", "") or "") + if rl in {"image", "chart", "figure"}: + result.append(b) + elif not rl.strip(): + result.append(b) + elif rl == "table" and "= 2`. + +Current code already has this function. It uses caption y-boundaries (midpoints between adjacent captions) and assigns assets by center-y. It handles narrow sidecar captions, captions above vs below assets, and free-floating margin. + +```python +if n_legends >= 2: + band_map = _partition_assets_by_caption_bands(page_legends, page_assets, page_height) + partitions = list(band_map.values()) + unaffiliated = [a for a in page_assets if id(a) not in {id(x) for p in partitions for x in p}] + if unaffiliated: + partitions.append(unaffiliated) # cluster unaffiliated separately +``` + +### 3.3 Distance clustering ```python def _cluster_page_assets( page_assets: list[dict], all_blocks: list[dict], + n_legends: int, page_width: float, + page_height: float, ) -> list[list[dict]]: - """Cluster assets by spatial proximity with text-separator awareness.""" if len(page_assets) <= 1: return [list(page_assets)] - # Get page height from first asset's bbox - page_height = 1600.0 # default - for b in all_blocks: - ph = b.get("page_height") - if ph: - page_height = float(ph) - break - h_threshold = max(page_width * 0.12, 40.0) - v_threshold = max(page_height * 0.08, 40.0) - - # Union-find + v_threshold = max(min(page_width, page_height) * 0.08, 40.0) parent = list(range(len(page_assets))) def find(x): @@ -257,24 +163,28 @@ def _cluster_page_assets( v_gap = max(0.0, bb[1] - ab[3], ab[1] - bb[3]) if h_gap > h_threshold: - # Check y-overlap for irregular layouts - a_y1, a_y2 = ab[1], ab[3] - b_y1, b_y2 = bb[1], bb[3] - y_overlap = max(0, min(a_y2, b_y2) - max(a_y1, b_y1)) - shorter_h = min(a_y2 - a_y1, b_y2 - b_y1) - if shorter_h > 0 and y_overlap / shorter_h < 0.5: - continue # no horizontal overlap and not vertically aligned → separate clusters + # Irregular layout: allow wider x-gap if y-overlap is significant + if n_legends <= 1: + a_y1, a_y2 = ab[1], ab[3] + b_y1, b_y2 = bb[1], bb[3] + y_overlap = max(0, min(a_y2, b_y2) - max(a_y1, b_y1)) + shorter_h = min(a_y2 - a_y1, b_y2 - b_y1) + if shorter_h > 0 and y_overlap / shorter_h >= 0.5: + if h_gap > page_width * 0.25: + continue + else: + continue + else: + continue if v_gap > v_threshold: - continue # too far apart vertically → separate clusters + continue - # Text separator check if _has_text_separator(a, b, all_blocks): continue union(i, j) - # Build clusters clusters: dict[int, list[dict]] = {} for i, block in enumerate(page_assets): root = find(i) @@ -285,92 +195,206 @@ def _cluster_page_assets( return list(clusters.values()) ``` -**`_has_text_separator()`** — new function: +### 3.4 Text separator (control flow fixed) ```python -def _has_text_separator(a: dict, b: dict, all_blocks: list[dict]) -> bool: - """True if body text or heading exists in the gap between assets a and b.""" +def _rect_intersection_area(a, b) -> float: + x1 = max(a[0], b[0]) + y1 = max(a[1], b[1]) + x2 = min(a[2], b[2]) + y2 = min(a[3], b[3]) + return max(0.0, x2 - x1) * max(0.0, y2 - y1) + + +def _has_text_separator(a: dict, b: dict, page_blocks: list[dict]) -> bool: ab = a.get("bbox", [0, 0, 0, 0]) bb = b.get("bbox", [0, 0, 0, 0]) + a_page = a.get("page") - gap_top = min(ab[3], bb[3]) - gap_bot = max(ab[1], bb[1]) - if gap_bot <= gap_top: - return False # assets overlap vertically, no gap to check + a_y1, a_y2 = ab[1], ab[3] + b_y1, b_y2 = bb[1], bb[3] + a_x1, a_x2 = ab[0], ab[2] + b_x1, b_x2 = bb[0], bb[2] - gap_left = min(ab[0], bb[0]) - gap_right = max(ab[2], bb[2]) + v_overlap = max(0.0, min(a_y2, b_y2) - max(a_y1, b_y1)) + h_gap = max(0.0, b_x1 - a_x2, a_x1 - b_x2) + h_overlap = max(0.0, min(a_x2, b_x2) - max(a_x1, b_x1)) + v_gap = max(0.0, b_y1 - a_y2, a_y1 - b_y2) - for block in all_blocks: + if v_overlap > 0 and h_gap > 0: + # Side-by-side: check vertical strip between them + gap_rect = [min(a_x2, b_x2), max(a_y1, b_y1), max(a_x1, b_x1), min(a_y2, b_y2)] + elif h_overlap > 0 and v_gap > 0: + # Stacked: check horizontal strip between them + gap_rect = [max(a_x1, b_x1), min(a_y2, b_y2), min(a_x2, b_x2), max(a_y1, b_y1)] + else: + # Diagonal: use bounding rect of both, subtract asset areas + gap_rect = [min(a_x1, b_x1), min(a_y1, b_y1), max(a_x2, b_x2), max(a_y2, b_y2)] + + for block in page_blocks: + if block.get("page") != a_page: + continue role = block.get("role", "") - if role not in ("body_paragraph", "section_heading", "subsection_heading"): + if role not in ("body_paragraph", "section_heading", "subsection_heading", + "backmatter_heading", "backmatter_body"): continue txt = str(block.get("text", "") or "").strip() - if not txt: + if not txt or len(txt) < 10: continue cb = block.get("bbox", [0, 0, 0, 0]) - # Block must be inside the gap rectangle - if (cb[0] >= gap_left and cb[2] <= gap_right - and cb[1] >= gap_top and cb[3] <= gap_bot): + block_area = max(1.0, (cb[2] - cb[0]) * (cb[3] - cb[1])) + if _rect_intersection_area(gap_rect, cb) / block_area >= 0.3: return True return False ``` -**`_score_legend_to_group()`** — modification: +### 3.5 Scoring ```python -# Add before the `if gt == "page_assets":` block: +def _score_legend_to_group( + legend: dict, group: dict, *, + caption_score: dict, page_width: float = 1200, + anchor_supported: bool = False, caption_text_supported: bool = False, + family_supported: bool = False, zone_supported: bool = False, +) -> dict: + gt = group.get("group_type", "") + if gt == "distance_cluster": - return { - "score": 0.85, - "decision": "matched", - "evidence": ["same_page", "distance_clustered"], - } + num_assets = len(group.get("media_blocks", [])) + if group.get("safe_auto_match") and num_assets >= 2: + return {"score": 0.85, "decision": "matched", + "evidence": ["same_page", "distance_clustered", "safe_auto_match"]} + + cluster_bbox = group.get("cluster_bbox", [0, 0, 0, 0]) + match_score = score_figure_match( + legend, + {"bbox": cluster_bbox, "page": group.get("page", 0)}, + caption_score=caption_score, + anchor_supported=anchor_supported, + caption_text_supported=caption_text_supported, + family_supported=family_supported, + zone_supported=zone_supported, + ) + if num_assets >= 2 and match_score.get("score", 0) > 0: + match_score = dict(match_score) + match_score["score"] = min(1.0, match_score["score"] + 0.15) + match_score.setdefault("evidence", []).append("multi_asset_coherence_bonus") + if match_score["score"] >= 0.5 and match_score.get("decision") in ("candidate", "ambiguous"): + match_score["decision"] = "matched" + return match_score + + if gt == "single_asset": + asset = group["media_blocks"][0] + return score_figure_match( + legend, asset, + caption_score=caption_score, + anchor_supported=anchor_supported, + caption_text_supported=caption_text_supported, + family_supported=family_supported, + zone_supported=zone_supported, + ) + + # Keep existing handling for page_assets and same_row groups + # (will be removed when those group types are eliminated in a follow-up) + ... ``` -This replaces the 0.55 flat score for `page_assets` with a 0.85 guaranteed match for distance-clustered groups. +### 3.6 Group-aware sequential fallback + +In `build_figure_inventory`, after per-page matching: + +```python +# Track used groups across the entire paper +used_group_ids: set[str] = set() +# ... (existing per-page matching loop marks used_group_ids) ... + +# Build unmatched candidate groups for sequential fallback +unmatched_groups = [ + g for g in candidate_groups + if g["group_id"] not in used_group_ids + and not any( + (g["page"], bid) in used_asset_page_ids + for bid in g["asset_block_ids"] + ) +] +unmatched_groups.sort(key=lambda g: (g["page"], g["cluster_bbox"][1] if g.get("cluster_bbox") else 0)) + +# Sequential fallback: try group-aware first +for legend in unmatched_legends: + lg_page = legend.get("page") + # Find best unmatched group (prefer same-page cluster, then adjacent page cluster) + candidates = [g for g in unmatched_groups + if g["page"] in (lg_page - 1, lg_page, lg_page + 1) + and g["group_id"] not in used_group_ids] + if not candidates: + continue # fall through to existing single-asset fallback + best = candidates[0] # nearest page, then reading order + # Claim all assets in the group + for bid in best["asset_block_ids"]: + for asset in assets: + if str(asset.get("block_id", "")) == str(bid): + matched_assets.append(asset) + used_asset_page_ids.add((best["page"], bid)) + used_group_ids.add(best["group_id"]) + # Create figure entry with all matched assets + ... + +# Existing single-asset sequential fallback for any remaining unmatched legends +# (unchanged, as last resort) +``` --- -## 5. Acceptance criteria +## 4. Edge-case matrix -1. **SAN9AYVR Figure 23**: All sub-panels (a-h) merged into one figure, 0 unmatched assets on page 50. -2. **2GN9LMCW Figure 4**: All 6 assets merged (was previously partially merged). -3. **DWQQK2YB Figure 2**: Stays correctly on page 38 with 19 assets (existing fix, must not regress). -4. **3FDT9652**: No regression on multi-column figures (separate figures in different columns with their own captions must not merge). -5. **2GN9LMCW Figures 1-3**: Single-panel figures remain as independent figures (clusters of size 1). -6. **No page-swallow**: A page with 10+ assets across 3 separate figures must not merge them all (text separator + caption-as-boundary prevents this). +| # | Scenario | Detection | Handling | Fallback | +|---|----------|-----------|----------|----------| +| 1 | One page, 2+ separate figures | n_legends >= 2 | Caption bands partition BEFORE clustering | single_asset per band, score_figure_match | +| 2 | Cross-page figure | n_legends == 0 on page | Orphan cluster → group-aware sequential fallback | Old single-asset fallback | +| 3 | Dense old-journal layout | Text separator | Don't merge across | Distance threshold + no separator → allow | +| 4 | Irregular layout (1 tall + 3 small) | y_overlap >= 50%, x_gap <= 25% pw, n_legends <= 1 | Force merge | Over-merge prevented by caption bands | +| 5 | Embedded caption in figure | Caption is not an asset | Ignored by clustering | N/A | +| 6 | Figure + table on same page | Type filter splits | Cluster separately | Position-only fallback | +| 7 | Multi-col figures same y-band | n_legends >= 2 | Caption bands prevent cross-band union | single_asset per band | +| 8 | Orphan single-panel figure | Cluster size 1 | single_asset → score_figure_match | N/A | +| 9 | Text-separated figures | Text separator exists | Don't merge across | No separator → allow distance merge | +| 10 | Very large multi-panel | Many assets, single legend | Cluster merges all within thresholds | Group-aware sequential fallback | +| 11 | Single legend + multiple unrelated clusters | n_legends==1, n_clusters>1 | Highest-scoring cluster wins, rest unmatched | Sequential group fallback | --- -## 6. Risks and mitigations - -| Risk | Likelihood | Impact | Mitigation | -|------|-----------|--------|------------| -| Over-merge (2 separate figs → 1 cluster) | Medium | Medium | Caption-as-boundary split when n_legends >= 2 | -| Under-merge (single fig → 2+ clusters) | Low | Low | `_expand_matched_assets_locally` collects orphans | -| Text separator false positive (body text between sub-panels of same fig) | Low | Medium | Text inside display_zone is usually caption/figure text, not body_paragraph. Real body text between sub-panels is rare in published papers. | -| Distance threshold too tight for large figures | Low | Low | y-overlap signal merges irregular layouts. Cross-page fallback catches stragglers. | -| Performance (pairwise O(n²)) | Low | Low | Pages with > 50 assets are rare (< 1% of corpus). Union-find is O(n log n). | - ---- - -## 7. Files summary +## 5. Files to change | File | Action | |------|--------| -| `paperforge/worker/ocr_figures.py` | Replace `_build_candidate_figure_groups_from_assets` body; add `_cluster_page_assets` + `_has_text_separator`; delete `_grow_region_from_seed` + `_validate_grown_region`; modify `_score_legend_to_group` | -| `tests/test_ocr_figures.py` | Add tests for distance clustering, text separator, multi-legend split, irregular layout | -| `tests/test_ocr_real_paper_regressions.py` | Add SAN9AYVR regression test for Figure 23 merge | -| `PROJECT-MANAGEMENT.md` | Updated with analysis (already done) | +| `paperforge/worker/ocr_figures.py` | Add `_filter_figure_assets`; replace `_build_candidate_figure_groups_from_assets`; add `_cluster_page_assets`, `_has_text_separator`; delete `_grow_region_from_seed`, `_validate_grown_region`, `_asset_gap_left`, `_asset_gap_above`; modify `_score_legend_to_group`; add group-aware sequential fallback; update `build_figure_inventory` call site | +| `tests/test_ocr_figures.py` | Unit tests: 2x2 cluster, text separator, multi-caption bands, irregular layout, scoring | +| `tests/test_ocr_real_paper_regressions.py` | Production replay: SAN9AYVR Fig 23, 2GN9LMCW Fig 4, DWQQK2YB Fig 2, 3FDT9652 | --- -## 8. Rejected alternatives +## 6. What to keep vs delete -| Alternative | Why rejected | -|-------------|-------------| -| Fix region-growth scoring (new bonus/threshold) | Doesn't solve the greedy-first-seed-wins problem | -| Add more growth directions (8-direction) | Still local, still greedy, still no backtracking | -| Machine learning for figure grouping | Over-engineering. Distance clustering is deterministic, auditable, and sufficient. | -| Per-page manual layout templates | Not generalizable to arbitrary journal formats | +| Code | Action | +|------|--------| +| `_media_clusters` | KEEP (used by other paths) | +| `_candidate_group_entry` | KEEP (unchanged) | +| `_cluster_bbox` | KEEP (unchanged) | +| `_expand_matched_assets_locally` | KEEP (unchanged, same-page only) | +| `_partition_assets_by_caption_bands` | KEEP and REUSE for multi-legend pages | +| `_grow_region_from_seed` | DELETE | +| `_validate_grown_region` | DELETE | +| `_asset_gap_left`, `_asset_gap_above` | DELETE | +| Existing sequential fallback (single-asset) | KEEP as last resort | + +--- + +## 7. Acceptance criteria + +1. SAN9AYVR Figure 23: expected panel block_ids all in matched_assets. +2. 2GN9LMCW Figure 4: 6 assets merged. +3. DWQQK2YB Figure 2: page 38, 19 assets (no regression). +4. 3FDT9652: multi-col figures NOT merged. +5. 2GN9LMCW Figures 1-3: single-panel independent (cluster size 1). +6. Single legend + multiple figures (K7R8PEKW): best cluster wins, group-aware fallback consumes rest. +7. No page-swallow regression. diff --git a/paperforge/worker/ocr_blocks.py b/paperforge/worker/ocr_blocks.py index 1a51dbae..df92eb57 100644 --- a/paperforge/worker/ocr_blocks.py +++ b/paperforge/worker/ocr_blocks.py @@ -56,7 +56,13 @@ def _vertical_gap(a, b) -> float: def _merge_adjacent_headings(rows: list[dict]) -> None: """Merge consecutive heading-labeled raw blocks split by OCR line breaks. Called BEFORE seed role assignment on raw_blocks, using raw_label only. + + Does NOT merge when the second heading has a deeper numbering level + (e.g. ``"2.1. Materials"`` after ``"2. Methods"``), which indicates a + subsection that should stay separate from its parent section heading. """ + import re + _HEADING_NUMBER_DEPTH = re.compile(r"^\s*(\d+(?:\.\d+)*)") _COL_SPLIT_RATIO = 0.5 def _col(b): @@ -67,6 +73,12 @@ def _merge_adjacent_headings(rows: list[dict]) -> None: cx = (bb[0] + bb[2]) / 2 return 0 if cx < pw * _COL_SPLIT_RATIO else 1 + def _heading_depth(b: dict) -> int: + m = _HEADING_NUMBER_DEPTH.match(str(b.get("text") or "")) + if not m: + return 0 + return m.group(1).count(".") + 1 + i = 0 while i < len(rows) - 1: cur = rows[i] @@ -77,6 +89,7 @@ def _merge_adjacent_headings(rows: list[dict]) -> None: and cur.get("page") == nxt.get("page") and _col(cur) == _col(nxt) and _vertical_gap(cur, nxt) <= 30 # OCR line-wrap within same heading + and _heading_depth(cur) >= _heading_depth(nxt) # don't swallow deeper subsections ): cur["text"] = (str(cur.get("text", "")) + " " + str(nxt.get("text", ""))).strip() cur["bbox"] = _union_bbox(cur.get("bbox"), nxt.get("bbox")) diff --git a/paperforge/worker/ocr_health.py b/paperforge/worker/ocr_health.py index 8d4544dd..664c566f 100644 --- a/paperforge/worker/ocr_health.py +++ b/paperforge/worker/ocr_health.py @@ -172,29 +172,39 @@ def build_ocr_health( formal_legend_accounted = int(completeness.get("accounted_for", 0)) formal_legend_gaps = int(completeness.get("gap_count", 0)) - issues = 0 - if caption_without_media > 0: - issues += 1 - if media_without_caption > 0: - issues += 1 - if empty_tables > 0: - issues += 1 + # Only flag structural blockers as health-color issues. + # Caption/media gaps, empty tables, legend gaps, layout anomalies + # are kept in the report as data but do NOT drive the overall color — + # they are display-quality concerns, not rebuild triggers. + structural_blockers = 0 if not abstract_found: - issues += 1 + structural_blockers += 1 if not references_found: - issues += 1 + structural_blockers += 1 if section_heading_count < 2: - issues += 1 - if formal_legend_gaps > 0: - issues += 1 + structural_blockers += 1 - if issues == 0 and frontmatter_quality >= 0.5: + # Count soft issues for the report (informational only) + soft_issues = 0 + if caption_without_media > 0: + soft_issues += 1 + if media_without_caption > 0: + soft_issues += 1 + if empty_tables > 0: + soft_issues += 1 + if formal_legend_gaps > 0: + soft_issues += 1 + + if structural_blockers == 0: overall = "green" - elif issues <= 2: + elif structural_blockers == 1: overall = "yellow" else: overall = "red" + # needs_rebuild: only when structural core is broken + needs_rebuild = structural_blockers >= 2 or (not abstract_found and not references_found) + # Compute structural health signals from paperforge.worker.ocr_document import _compute_span_coverage, _detect_body_spine, _run_layout_audit @@ -276,6 +286,9 @@ def build_ocr_health( "empty_table_count": empty_tables, "frontmatter_quality": frontmatter_quality, "overall": overall, + "needs_rebuild": needs_rebuild, + "structural_blockers": structural_blockers, + "soft_issues": soft_issues, "span_coverage": span, "span_coverage_quality": span.get("coverage_quality", "weak"), "degraded_mode_active": span.get("degraded_mode_active", True), diff --git a/paperforge/worker/ocr_pdf_spans.py b/paperforge/worker/ocr_pdf_spans.py index e9cde0b8..dae569fc 100644 --- a/paperforge/worker/ocr_pdf_spans.py +++ b/paperforge/worker/ocr_pdf_spans.py @@ -370,7 +370,10 @@ def backfill_missing_text_from_pdf( or block.get("block_content") or "" ).strip() - if current_text: + # Ponytail: "text" field may be JSON list [] from raw block format, + # not a string. str([]) → "[]" which is truthy but has no real text. + # Detect and treat as empty. + if current_text and current_text not in ("[]", "[ ]"): continue # Guard: must have span_metadata as PDF evidence @@ -442,6 +445,7 @@ def backfill_missing_text_from_pdf( block["_text_source"] = "pdf_text_layer_fallback" block["_ocr_raw_status"] = "missing_text_recovered" block["_ocr_raw_error_type"] = "empty_text_with_pdf_evidence" + block["role"] = "body_paragraph" recovered += 1 else: try: diff --git a/paperforge/worker/ocr_reference_signals.py b/paperforge/worker/ocr_reference_signals.py new file mode 100644 index 00000000..ed8dacca --- /dev/null +++ b/paperforge/worker/ocr_reference_signals.py @@ -0,0 +1,61 @@ +from __future__ import annotations + +import json +import re +from functools import lru_cache +from importlib import resources + + +def _norm(text: str) -> str: + return re.sub(r"\s+", " ", re.sub(r"[^A-Za-z0-9 ]+", " ", text)).strip().lower() + + +@lru_cache(maxsize=1) +def _journal_rows() -> list[dict]: + raw = resources.files("paperforge.resources").joinpath("nlm_journal_abbreviations.json").read_text(encoding="utf-8") + return json.loads(raw) + + +def _has_journal_match(text: str) -> bool: + norm = _norm(text) + for row in _journal_rows(): + for field in ("med_abbr", "iso_abbr", "canonical_title"): + value = _norm(str(row.get(field) or "")) + if value and value in norm: + return True + return False + + +def score_reference_entry(text: str) -> dict: + text = str(text or "").strip() + lower = text.lower() + has_author_signature = bool(re.search(r"\b[A-Z][a-zA-Z'\-]+\s+[A-Z]{1,3}(?:,|\b)", text)) + has_year = bool(re.search(r"\b(19|20)\d{2}\b", text)) + has_vol_pages = bool(re.search(r"\b\d+\s*\(\d+\)\s*:\s*[A-Za-z0-9\-]+", text) or re.search(r"\b\d+\s*:\s*[A-Za-z0-9\-]+", text)) + has_online = any(token in lower for token in ("[internet]", "available from", "doi:", "pmid:", "pmcid:", "published online", "cited ")) + has_report_markers = any(token in lower for token in ("guideline", "organization", "committee", "available from")) or "[internet]" in lower + has_number_lead = bool(re.match(r"^\s*(\[\d+\]|\d+[\.)]?)(\s+|$)", text)) + journal_match = _has_journal_match(text) + + family = "unknown" + confidence = 0.0 + if has_author_signature and has_year and (has_vol_pages or journal_match): + family = "vancouver_structured_numbered" if has_number_lead else "vancouver_structured_unnumbered" + confidence = 0.8 if journal_match else 0.65 + elif has_report_markers and has_year: + family = "book_or_report" + confidence = 0.7 + elif re.search(r"\b[A-Z][a-zA-Z'\-]+\s+[A-Z].*\((19|20)\d{2}\)", text): + family = "author_year" + confidence = 0.6 + return { + "family": family, + "confidence": confidence, + "signals": { + "author_signature": has_author_signature, + "year_signature": has_year, + "volume_issue_pages_signature": has_vol_pages, + "online_marker_signature": has_online, + "journal_lexicon_match": journal_match, + }, + } diff --git a/paperforge/worker/ocr_scores.py b/paperforge/worker/ocr_scores.py index bab647c5..9a6f8ff4 100644 --- a/paperforge/worker/ocr_scores.py +++ b/paperforge/worker/ocr_scores.py @@ -116,6 +116,14 @@ def score_figure_match( has_x_overlap = True score += 0.25 evidence.append("x_overlap") + elif len(legend_bbox) >= 4 and len(asset_bbox) >= 4: + # Side-by-side: no x_overlap but adjacent columns with shared y-band + gap = max(0.0, asset_bbox[0] - legend_bbox[2], legend_bbox[0] - asset_bbox[2]) + narrow_w = min(legend_bbox[2] - legend_bbox[0], asset_bbox[2] - asset_bbox[0]) + if gap < narrow_w * 0.3 and gap < 80: + has_x_overlap = True + score += 0.20 + evidence.append("adjacent_x") if len(legend_bbox) >= 4 and len(asset_bbox) >= 4: vertical_gap = min(abs(legend_bbox[1] - asset_bbox[3]), abs(asset_bbox[1] - legend_bbox[3])) if vertical_gap <= 300: diff --git a/paperforge/worker/ocr_structural_gate.py b/paperforge/worker/ocr_structural_gate.py index b7da8193..8403a787 100644 --- a/paperforge/worker/ocr_structural_gate.py +++ b/paperforge/worker/ocr_structural_gate.py @@ -509,42 +509,108 @@ def _matches_zone_id(block: dict, zone_ids: set) -> bool: return bid in zone_ids or f"p{page}:{bid}" in zone_ids -def _extend_reference_items_with_continuations( +def _is_reference_anchor(block: dict) -> bool: + role = block.get("role") or block.get("seed_role") + if role in {"reference_heading", "reference_item"}: + return True + seed = block.get("seed_role") + if seed in {"reference_heading", "reference_item"}: + return True + return False + + +def _is_reference_like(block: dict) -> bool: + if _is_reference_anchor(block): + return True + role = block.get("role") or "" + if role in {"reference_item", "reference_heading"}: + return True + seed = block.get("seed_role") or "" + if seed == "reference_item": + return True + return False + + +def _block_sort_key(block: dict) -> tuple: + page = int(block.get("page", 0) or 0) + bbox = block.get("bbox") or [0, 0, 0, 0] + col = 0 if len(bbox) < 4 else (0 if float(bbox[0]) < 600 else 1) + y = float(bbox[1]) if len(bbox) >= 2 else 0.0 + x = float(bbox[0]) if len(bbox) >= 1 else 0.0 + return (page, col, y, x) + + +def _fill_gap_between_anchors( blocks: list[dict], - item_ids: list, - heading_id: str | int | None, + anchor_before: dict, + anchor_after: dict, duplicate_ids: set[str], ) -> list: - """Extend reference item_ids with continuation lines following known items.""" - item_id_set = set(item_ids) - active_ref: str | int | None = None - result = list(item_ids) + gap_ids: list = [] + b_before = _block_sort_key(anchor_before) + b_after = _block_sort_key(anchor_after) + for block in blocks: + key = _block_sort_key(block) + if not (b_before < key < b_after): + continue + role = block.get("role") or block.get("seed_role") + text = str(block.get("text") or "").strip() + if not text: + continue + skip_roles = {"section_heading", "subsection_heading", "sub_subsection_heading", + "backmatter_heading", "backmatter_body", "figure_caption", + "figure_asset", "media_asset", "table_caption", "table_html", + "table_asset", "structured_insert", "non_body_insert", + "frontmatter_support", "noise", "frontmatter_noise"} + if role in skip_roles: + continue + if _is_reference_like(block): + artifact_id = _artifact_block_id(block, duplicate_ids) + if artifact_id is not None: + gap_ids.append(artifact_id) + return gap_ids + +def _build_ordered_reference_items( + blocks: list[dict], + anchor_ids: set, + duplicate_ids: set[str], + heading_id: str | int | None = None, + region_ids: set | None = None, +) -> list: + """Build reference item_ids from ordered reference anchors with bounded gap repair.""" + anchors: list[dict] = [] for block in blocks: artifact_id = _artifact_block_id(block, duplicate_ids) if artifact_id is None: continue if heading_id is not None and artifact_id == heading_id: continue + in_anchor = artifact_id in anchor_ids + in_region = region_ids and _matches_zone_id(block, region_ids) + if (in_anchor or in_region) and _is_reference_anchor(block): + anchors.append(block) - if artifact_id in item_id_set: - active_ref = artifact_id - continue + if not anchors: + return [] - if active_ref is None: - continue + anchors.sort(key=_block_sort_key) - role = block.get("role") or block.get("seed_role") - text = str(block.get("text") or "").strip() - if not text: + result: list = [] + anchor_ids_result: set = set() + for i, anchor in enumerate(anchors): + aid = _artifact_block_id(anchor, duplicate_ids) + if aid is None or aid in anchor_ids_result: continue - if role in {"noise", "frontmatter_noise", "media_asset", "figure_asset"}: - continue - if role in {"section_heading", "subsection_heading", "backmatter_heading"}: - active_ref = None - continue - - result.append(artifact_id) + anchor_ids_result.add(aid) + result.append(aid) + if i + 1 < len(anchors): + next_anchor = anchors[i + 1] + next_key = _block_sort_key(next_anchor) + gap = _fill_gap_between_anchors(blocks, anchor, next_anchor, duplicate_ids) + for gid in gap: + if gid not in result and gid != heading_id: + result.append(gid) return result @@ -563,6 +629,14 @@ def build_verified_reference_zone_from_artifacts(blocks: list[dict], artifacts: tail_spread = artifacts.get("tail_spread") or {} numbering = artifacts.get("reference_numbering_family") or {} region_ids = set(_obj_get(region_bus, "reference_zone_ids", set())) + # Expand region_ids with all blocks that carry reference_zone label + # or reference_item role from per-block assignment (parallel to region_bus). + for block in blocks: + if block.get("zone") == "reference_zone" and _is_reference_anchor(block): + artifact_id = _artifact_block_id(block, duplicate_ids) + if artifact_id is not None: + region_ids.add(artifact_id) + region_ids.add(str(artifact_id)) accepted_numbering_ids = set(_obj_get(numbering, "accepted_item_ids", set())) end_before = _obj_get(tail_spread, "reference_end_before_block_id") before_tail = set() @@ -591,18 +665,22 @@ def build_verified_reference_zone_from_artifacts(blocks: list[dict], artifacts: matched_block = next((b for b in blocks if b.get("block_id") == item_id), None) item_ids.append(_artifact_block_id(matched_block, duplicate_ids) if matched_block is not None else item_id) - # When anchor doesn't provide item_block_ids (real data model like - # discover_reference_family_anchor in ocr_families.py only has - # metadata keys: status, item_count, sample_pages, etc.), - # extract items from region_bus reference_zone block_ids. + heading_id = _obj_get(anchor, "heading_block_id") + + # When anchor doesn't provide item_block_ids, build from region_bus + # reference_zone_ids and then extend through ordered reference anchors + # with bounded gap repair instead of greedy continuation. if not item_ids and region_ids: + anchor_ids: set = set() for block in blocks: - if _matches_zone_id(block, region_ids): + if _matches_zone_id(block, region_ids) and _is_reference_anchor(block): artifact_id = _artifact_block_id(block, duplicate_ids) if artifact_id is not None: - item_ids.append(artifact_id) + anchor_ids.add(artifact_id) + item_ids = _build_ordered_reference_items( + blocks, anchor_ids, duplicate_ids, heading_id, region_ids + ) - heading_id = _obj_get(anchor, "heading_block_id") if not heading_id and region_ids: for block in blocks: if _matches_zone_id(block, region_ids) and str(block.get("text", "") or "").strip().lower() in { @@ -622,18 +700,23 @@ def build_verified_reference_zone_from_artifacts(blocks: list[dict], artifacts: if heading_id is not None and heading_id in item_ids: item_ids.remove(heading_id) - # Extend reference items with continuation lines following known items + # Extend reference items through ordered reference-anchor sequence + # with bounded gap repair, not greedy continuation. if item_ids: - item_ids = _extend_reference_items_with_continuations( - blocks, item_ids, heading_id, duplicate_ids + item_ids = _build_ordered_reference_items( + blocks, set(item_ids), duplicate_ids, heading_id, region_ids ) - return { + zone = { "heading_block_id": heading_id, "item_block_ids": item_ids, "status": "ACCEPT" if heading_id and item_ids else "HOLD", "evidence": ["reference zone from anchor, region bus, tail boundary, and numbering continuity"], } + if zone.get("status") == "HOLD": + zone["item_block_ids"] = [] + zone["heading_block_id"] = None + return zone def compute_role_gate_health(decisions: list[VerifiedRoleDecision]) -> dict: diff --git a/paperforge/worker/ocr_tables.py b/paperforge/worker/ocr_tables.py index 313ad4da..0a6b3f79 100644 --- a/paperforge/worker/ocr_tables.py +++ b/paperforge/worker/ocr_tables.py @@ -147,7 +147,9 @@ def build_table_inventory(structured_blocks: list[dict]) -> dict[str, Any]: raw_label = str(block.get("raw_label", "") or "").strip() if role in {"table_caption", "table_caption_candidate"} or _is_validation_first_table_candidate(block): captions.append(block) - elif role in ("table_asset", "media_asset"): + elif role in ("table_asset", "media_asset", "figure_asset"): + if role == "figure_asset" and raw_label != "table": + continue if role == "media_asset": bbox = block.get("bbox") or block.get("block_bbox") or [0, 0, 0, 0] width = (bbox[2] - bbox[0]) if len(bbox) >= 4 else 0 @@ -181,7 +183,13 @@ def build_table_inventory(structured_blocks: list[dict]) -> dict[str, Any]: is_weak_explicit_caption = _is_weak_explicit_table_caption(caption) if is_validation_first_candidate and is_weak_truncated: - held_tables.append( + # Check if same-page table assets exist before holding. + same_page_assets = [ + a for i,a in enumerate(assets) + if i not in used_asset_indices and a.get('page',0) == caption_page + ] + if not same_page_assets: + held_tables.append( { "table_id": f"held_table_{len(held_tables) + 1:03d}", "caption_block_id": caption.get("block_id", ""), @@ -196,6 +204,11 @@ def build_table_inventory(structured_blocks: list[dict]) -> dict[str, Any]: } ) continue + if is_weak_truncated: + # Truncated table label with same-page assets: proceed + # to weak-explicit matching (same as figure's truncated + # legend now matching to nearby assets). + pass if is_weak_explicit_caption: candidate_pages = [caption_page - 1, caption_page, caption_page + 1] pre_candidates: list[tuple[int, dict, dict]] = [] @@ -405,6 +418,14 @@ def build_table_inventory(structured_blocks: list[dict]) -> dict[str, Any]: consumed_block_ids.append(matched_asset.get("block_id", "")) consumed_block_ids.extend(note_block_ids) consumed_block_ids = [bid for bid in consumed_block_ids if bid] + bridge_block_ids = [ + str(block.get("block_id") or "") + for block in structured_blocks + if int(block.get("page", 0) or 0) == int(caption_page or 0) + and block.get("bridge_eligible") + and str(block.get("layout_region") or "") == "display_zone" + and block.get("block_id") + ] tables.append( { @@ -425,6 +446,7 @@ def build_table_inventory(structured_blocks: list[dict]) -> dict[str, Any]: "note_band_bbox": note_band_bbox, "note_match_reason": note_match_reason, "note_confidence": note_confidence, + "bridge_block_ids": bridge_block_ids, "consumed_block_ids": consumed_block_ids, "is_continuation": is_cont, "continuation_of": continuation_of, diff --git a/tests/fixtures/ocr_real_papers/23T2B8ZX/block_trace.csv b/tests/fixtures/ocr_real_papers/23T2B8ZX/block_trace.csv new file mode 100644 index 00000000..93364478 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/23T2B8ZX/block_trace.csv @@ -0,0 +1,159 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,J Shoulder Elbow Surg (2018),"[104, 64, 305, 84]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,header_image,,"[106, 103, 216, 199]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,header,ARTICLE IN PRESS,"[419, 9, 799, 51]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,"JOURNAL OF +SHOULDER AND +ELBOW +SURGERY","[949, 79, 1110, 175]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,header,www.elsevier.com/locate/ymse,"[911, 191, 1115, 211]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,5,text,ORIGINAL ARTICLE,"[103, 248, 301, 276]",authors,0.6,"[""page-1 initial-lastname author byline: ORIGINAL ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,6,doc_title,Predictive findings on magnetic resonance imaging in patients with symptomatic acromioclavicular osteoarthritis,"[101, 309, 826, 447]",paper_title,0.8,"[""page-1 zone title_zone: Predictive findings on magnetic resonance imaging in patient""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text,"Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $ ^{a} $, Robin E. Westerbeek, MD $ ^{c} $, Rosalie P.H. Derks, MD $ ^{c} $, Ellie B.M. Landman, PhD $ ^{a} $, Cornelis T. Koorevaar, MD, PhD","[102, 475, 1076, 542]",authors,0.8,"[""page-1 zone author_zone: Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,8,text," $ ^{a} $Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, Deventer, The Netherlands + $ ^{b} $Department of Orthopaedic Surgery, University Medical Center, University of Groningen","[101, 570, 1069, 646]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $Department of Orthopaedic Surgery and Traumatology, ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,9,abstract,Background: A magnetic resonance imaging (MRI) scan of the shoulder can have added value in diagnosing symptomatic osteoarthritis of the acromioclavicular (AC) joint. Specific MRI signs have been reco,"[113, 684, 880, 774]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,abstract,Methods: The MRI scans of 70 patients with symptomatic AC osteoarthritis were compared with those of 70 patients with subacromial pain syndrome and no clinical signs of symptomatic AC osteoarthritis. ,"[114, 774, 881, 887]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,11,abstract,"Results: The presence of inferior osteophytes, bone marrow edema, impression on the supraspinatus, and inferior joint distension was individually associated with symptomatic AC osteoarthritis. Bone ma","[114, 885, 880, 1038]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,12,abstract,"Conclusion: We identified predictive MRI signs in patients with symptomatic AC osteoarthritis. These findings, including bone marrow edema, inferior joint distension, and impression on the supraspinat","[114, 1038, 879, 1126]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,13,text,"Level of evidence: Level IV; Case-Control Design; Diagnostic Study +© 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.","[115, 1125, 731, 1171]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Level of evidence: Level IV; Case-Control Design; Diagnostic""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,14,text,Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow edema; impression on musculus supraspinatus; predictive findings,"[114, 1176, 879, 1221]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,15,footnote,"Approval of this study was obtained from the regional Medical Ethical Committee (METC Isala, No. 15.0222).","[101, 1303, 833, 1324]",footnote,0.7,"[""footnote label: Approval of this study was obtained from the regional Medica""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,16,footnote," $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, PO Box 5001, NL-7400 GC Deventer, The Netherlands.","[102, 1321, 1116, 1366]",footnote,0.7,"[""footnote label: $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department o""]",footnote,0.7,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,17,footnote,E-mail address: ejdveen@gmail.com (E.J.D. Veen).,"[126, 1365, 464, 1385]",footnote,0.7,"[""footnote label: E-mail address: ejdveen@gmail.com (E.J.D. Veen).""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,18,footer,1058-2746/$ - see front matter © 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved. https://doi.org/10.1016/j.jse.2018.01.001,"[102, 1407, 875, 1449]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,0,number,2,"[75, 65, 88, 85]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,doc_title,ARTICLE IN PRESS,"[388, 10, 767, 51]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,short_fragment,False,True +2,2,header,E.J.D. Veen et al.,"[937, 65, 1081, 87]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,3,text,"Degeneration of the acromioclavicular (AC) joint, with joint space narrowing and osteophyte formation, is part of the normal aging process. $ ^{[10,19]} $ In most of the general population, osteoarthr","[70, 109, 558, 373]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"The diagnosis of symptomatic AC osteoarthritis is made by an accurate history, clinical examination, and additional radiodiagnostic imaging studies. Previous studies have debated the accuracy and reli","[70, 374, 557, 541]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,Previous research has shown that advanced signs of degeneration in the AC joint seen on the MRI scan are correlated with symptoms and that bone marrow edema is only observed in patients with symptomat,"[70, 542, 558, 685]",unknown_structural,0.8,"[""page-1 zone author_zone: Previous research has shown that advanced signs of degenerat""]",authors,0.8,body_zone,body_like,none,False,True +2,6,text,The aim of this study was to identify predictive MRI signs in patients with symptomatic AC osteoarthritis. We hypothesized that specific MRI signs would be found in patients with symptomatic AC osteoa,"[70, 685, 558, 783]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,Materials and methods Design,"[72, 808, 310, 887]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Materials and methods Design""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,False,True +2,8,footer,,"[72, 860, 142, 887]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,9,text,"This study had a retrospective, case-control, diagnostic study design and was conducted in a general teaching hospital with a specialized shoulder unit.","[70, 911, 557, 978]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,Study population,"[71, 1005, 238, 1031]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Study population""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,11,text,A total of 140 patients were selected from the electronic patient files: 70 consecutive patients with clinical isolated symptomatic AC osteoarthritis (group 1) and 70 consecutive patients with chronic,"[70, 1054, 558, 1187]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,text,Patients in both groups were recruited from our outpatient department: group 1 in 2009 to 2014 and group 2 in 2012 to 2014. The inclusion criteria for group 1 were pain localized in the AC joint that ,"[70, 1188, 558, 1452]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,text,"the AC joint and a positive cross-body adduction test. The exclusion +criteria for both groups were rheumatoid arthritis, a history of shoul- +der surgery or fracture, glenohumeral osteoarthritis, ruptu","[594, 109, 1084, 198]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,text,All patients with shoulder pain were reviewed in our shoulder unit by 2 experienced shoulder surgeons using a standard protocol for clinical history and clinical examination. Data were collected in a ,"[595, 198, 1085, 375]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,paragraph_title,Signs on MRI,"[598, 404, 726, 431]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Signs on MRI""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,short_fragment,True,True +2,16,text,"All MRI scans were performed 2 to 3 weeks after the outpatient visit in our hospital on a 1.5-T Signa HDx TwinSpeed1 MRI system (General Electric, Milwaukee, WI, USA). The shoulder was placed in a ded","[596, 454, 1084, 653]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,17,text,"On the basis of previous research and clinical experience, 7 variables were evaluated on the MRI scans:","[595, 654, 1083, 697]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,18,text,"1. AC joint space narrowing: minimal space between the clavicle and acromion on axial images, with the cutoff value for joint space narrowing set at 2 mm","[615, 717, 1084, 783]",body_paragraph,0.6,"[""reference-like pattern: 1. AC joint space narrowing: minimal space between the clavi""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,19,text,2. AC joint effusion: fluid-equivalent signal in the AC joint space,"[614, 784, 1084, 805]",body_paragraph,0.6,"[""reference-like pattern: 2. AC joint effusion: fluid-equivalent signal in the AC join""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,20,text,3. Subchondral bone marrow edema of the distal clavicle and/or medial acromion: hyperintense signal from cranial to caudal on fat-saturated T2-weighted images and hypointense signal on T1-weighted ima,"[615, 800, 1083, 894]",body_paragraph,0.6,"[""reference-like pattern: 3. Subchondral bone marrow edema of the distal clavicle and/""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,21,text,4. AC osteolysis: lytic bone lesion with cortical destruction of the distal clavicle,"[614, 894, 1084, 937]",body_paragraph,0.6,"[""reference-like pattern: 4. AC osteolysis: lytic bone lesion with cortical destructio""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,22,text,"5. AC inferior osteophytes: inferior osteophyte, 2 mm or longer (length measured from a horizontal line on the original undersurface of the clavicle on coronal images, Fig. 1).","[614, 938, 1084, 1004]",body_paragraph,0.6,"[""reference-like pattern: 5. AC inferior osteophytes: inferior osteophyte, 2 mm or lon""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,23,text,"6. Inferior AC joint distension: distal protrusion of the AC joint, 3 mm or longer (measured from a horizontal line on the original undersurface of the clavicle on sagittal or coronal images, Fig. 1).","[615, 1004, 1084, 1092]",body_paragraph,0.6,"[""reference-like pattern: 6. Inferior AC joint distension: distal protrusion of the AC""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,24,text,"7. Impression on the supraspinatus due to the AC joint: 3 scores (on sagittal T1 or proton density sequences): (1) normal fat between AC joint and supraspinatus, (2) no fat between AC joint and supras","[615, 1092, 1084, 1203]",body_paragraph,0.6,"[""reference-like pattern: 7. Impression on the supraspinatus due to the AC joint: 3 sc""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +2,25,text,"To enhance interpretation of the findings on MRI in clinical practice, variables were expressed dichotomously. Cutoff values for joint space narrowing, inferior osteophytes, and joint distension were ","[594, 1223, 1084, 1313]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,26,paragraph_title,Statistical analysis Demographic and clinical characteristics,"[596, 1341, 948, 1405]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical analysis Demographic and clinical characteristic""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,27,footer,,"[596, 1381, 948, 1405]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,28,text,"The demographic and clinical characteristics were presented as proportion, mean (standard deviation), or median (interquartile range)","[595, 1407, 1084, 1453]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,ARTICLE IN PRESS,"[420, 11, 798, 50]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,Signs on MRI for AC osteoarthritis,"[104, 64, 386, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,number,3,"[1100, 67, 1113, 85]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,3,image,,"[118, 115, 575, 489]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,"Figure 1 Measurement of inferior osteophyte (O) and inferior joint distension (JD) on coronal image from magnetic resonance imaging scan. A, acromion; Cl, clavicle; SS, supraspinatus; H, humerus.","[101, 505, 589, 573]",figure_caption,0.92,"[""figure_title label: Figure 1 Measurement of inferior osteophyte (O) and inferior""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,5,text,in the case of a skewed distribution. Differences between patients with symptomatic AC osteoarthritis and the control group were tested using independent-samples t tests for continuous variables or $,"[102, 599, 591, 689]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,Analysis of MRI predictors for symptomatic AC osteoarthritis,"[101, 713, 505, 760]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Analysis of MRI predictors for symptomatic AC osteoarthritis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,7,text,Univariate logistic regression analyses were performed to evaluate the association between each of the MRI findings individually and symptomatic AC osteoarthritis. MRI findings showing a significant a,"[101, 762, 591, 1202]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,paragraph_title,Intraobserver and interobserver variability,"[102, 1225, 510, 1250]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,9,text,"Intraobserver and interobserver variability was calculated for the findings of the final multivariate logistic regression model. This was done by calculating the k value, using data from 20 patients f","[101, 1274, 590, 1452]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"variability was evaluated by comparing the values within the panel +of judges; intraobserver variability was evaluated by scoring the vari- +ables twice by the panel of judges on 2 days in different wee","[626, 110, 1116, 244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,Results Demographic characteristics,"[628, 265, 901, 345]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Results Demographic characteristics""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,12,footer,,"[628, 318, 901, 345]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +3,13,text,"Figure 3 shows a flow diagram of study enrollment. Between 2009 and 2014, 126 consecutive patients presented with clinical symptoms of AC osteoarthritis. To include only patients with isolated symptom","[625, 369, 1116, 850]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 3 shows a flow diagram of study enrollment. Between 2""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +3,14,text,Complete demographic and clinical data for both groups are shown in Table I. Demographic parameters were comparable between the 2 groups. Significant differences were found between groups in the size ,"[626, 850, 1116, 1018]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,paragraph_title,MRI characteristics,"[628, 1040, 815, 1065]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: MRI characteristics""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +3,16,text,"Because bone marrow edema was found only in patients with symptomatic AC osteoarthritis and because osteolysis was not found in any patients, these variables were not included in the regression analys","[625, 1091, 1117, 1454]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,4,"[74, 66, 89, 86]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,ARTICLE IN PRESS,"[388, 11, 767, 51]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,header,E.J.D. Veen et al.,"[936, 64, 1081, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,image,,"[158, 115, 1001, 352]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,4,figure_title,"Figure 2 Compression of supraspinatus on sagittal images from magnetic resonance imaging scans: no contact (A), adjacent (B), and impression (C). A, acromion; Cl, clavicle; SS, supraspinatus; H, humer","[71, 369, 1085, 415]",figure_caption,0.92,"[""figure_title label: Figure 2 Compression of supraspinatus on sagittal images fro""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,5,image,,"[156, 444, 999, 898]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,6,figure_title,"Figure 3 Flowchart of study enrollment. AC, acromioclavicular.","[332, 923, 823, 946]",figure_caption,0.92,"[""figure_title label: Figure 3 Flowchart of study enrollment. AC, acromioclavicula""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,7,text,"confidence interval [CI], 3.53 to 36.44; P < .001 and joint distension (odds ratio, 3.38; 95% CI, 1.25 to 9.13; P = .016).","[70, 985, 556, 1033]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"The Hosmer-Lemeshow test for goodness of fit of the model including these 2 variables was performed including only those patients without bone marrow edema and was not significant $ (P = .963) $, ind","[69, 1034, 558, 1251]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,Intraobserver and interobserver variability,"[71, 1280, 478, 1306]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,10,text,"The mean κ value for intraobserver variability was 0.86 (95% CI, 0.75 to 1.00) for bone marrow edema, 0.68 (95% CI, 0.60 to 0.795) for AC joint distension, and 0.85 (95% CI, 0.75 to 0.94) for impressi","[69, 1331, 559, 1453]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,"edema, 0.70 (95% CI, 0.65 to 0.75) for AC joint distension, +and 0.84 (95% CI, 0.82 to 0.94) for impression. The mean +intraobserver variability and interobserver variability of im- +pression and bone ma","[594, 985, 1085, 1179]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,Discussion,"[598, 1204, 713, 1231]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,13,text,The most important finding of our study was the correlation of 3 MRI signs with the clinical diagnosis of symptomatic AC osteoarthritis. The presence of bone marrow edema predicted a 100% probability ,"[594, 1259, 1086, 1453]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,ARTICLE IN PRESS,"[420, 10, 799, 50]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,Signs on MRI for AC osteoarthritis,"[105, 64, 387, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,number,5,"[1100, 66, 1114, 85]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,3,figure_title,Table I Demographic and clinical data and MRI findings of study population,"[115, 121, 699, 144]",figure_caption_candidate,0.85,"[""figure_title label: Table I Demographic and clinical data and MRI findings of st""]",figure_caption,0.85,,reference_like,citation_line,False,False +5,4,table,"
Group 1 (n = 70)Group 2 (n = 70)P value
Male sex32 (45.7%)34 (48.6%).735
Mean age (SD), yr
Group 1 (n = 70)Group 2 (n = 70)Odds ratio (95% CI)P value
Joint space ≤2 mm57 (81%)71 (87%)0.647 (0.257-,"[113, 659, 1101, 850]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,11,vision_footnote,"MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval.","[115, 855, 651, 876]",footnote,0.7,"[""vision_footnote label: MRI, magnetic resonance imaging; AC, acromioclavicular; CI, ""]",footnote,0.7,body_zone,body_like,none,True,True +5,12,vision_footnote,"Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chronic subacromial pain syndrome.","[115, 876, 871, 897]",footnote,0.7,"[""vision_footnote label: Group 1 patients had symptomatic AC osteoarthritis, and grou""]",footnote,0.7,body_zone,body_like,none,True,True +5,13,figure_title,Table III Multivariate logistic regression analysis of predictors on MRI for symptomatic AC osteoarthritis,"[114, 955, 908, 978]",figure_caption,0.85,"[""figure_title label: Table III Multivariate logistic regression analysis of predi""]",figure_caption,0.85,body_zone,table_caption_like,none,True,True +5,14,table,<","[309, 208, 915, 554]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,unknown_like,none,True,True +4,4,figure_title,Source: own,"[557, 560, 668, 581]",figure_caption_candidate,0.85,"[""figure_title label: Source: own""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False +4,5,figure_title,Table 2: Dielectric constants of the biological samples.,"[366, 598, 856, 623]",table_caption,0.9,"[""table prefix matched: Table 2: Dielectric constants of the biological samples.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,6,table,"
VariableCoefficientOdds ratio (95% CI)P value
Inferior joint distension ≥3 mm1.2173.378 (1.249-9.133).016
ComponentParameterValueReference
Stainless-steel electrodeSeparation20 [mm][21]
Frequency (kHz)Reference
0.01110501001000
constructs for tissue engineering and regenerative medicine.
Construct fabrication strategiesApproachMagnetic roleExperimental se","[74, 203, 1090, 1409]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,4,vision_footnote,AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona,"[74, 1398, 1038, 1451]",footnote,0.7,"[""vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star""]",footnote,0.7,body_zone,body_like,none,True,True +4,5,number,556,"[71, 1529, 110, 1549]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,6,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877, 1533, 1095, 1553]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403, 99, 1007, 124]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header,Review,"[1031, 93, 1128, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,figure_title,Table 1. Compilation of studies reporting the use of magnetic stimulation for the development of 3D constructs for tissue engineering and regenerative medicine (cont.).,"[120, 183, 1080, 234]",table_caption,0.9,"[""table prefix matched: Table 1. Compilation of studies reporting the use of magneti""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,3,table,"
Construct fabrication strategiesApproachMagnetic roleExperimental set upApplicationRef.
Dispersion/impregnation","[117, 191, 1137, 1122]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,4,vision_footnote,AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona,"[118, 1129, 1082, 1181]",footnote,0.7,"[""vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star""]",footnote,0.7,body_zone,body_like,none,True,True +5,5,text,"of the scaffolds and insufficient migration of the cells into the scaffolds lead to a shortage of initially seeded cells, resulting in less significant outcomes. In this context, the functionalization","[112, 1208, 623, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,"the formulations in which the magnetic force was applied, thus +demonstrating the potential of this novel design for tissue engi- +neering purposes. Depending on the scaffold, an improvement on +cell see","[634, 1207, 1145, 1424]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,Other methods in which the application of magnetic fields can be useful are the bottom-up scaffold fabrication techniques. The assembly of building blocks such as cell-encapsulating microscale,"[635, 1424, 1145, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,footer,www.expert-reviews.com,"[115, 1534, 328, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,9,number,557,"[1103, 1528, 1141, 1550]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Review,"[87, 94, 183, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,"Santo, Rodrigues & Gomes","[206, 98, 458, 121]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,2,text,"hydrogels mimics the structure of native tissues, typically composed by repeating functional units [43]. Despite the promising opportunities provided by this approach, the control over this assembly i","[67, 177, 577, 848]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,3,text,A recent report by Tasoglu et al. has shown that the magnetic assembly can be provided in the absence of MNPs [43]. The results demonstrate that PEG hydrogels that were exposed to UV radiation for lon,"[69, 849, 577, 898]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,text,"demonstrate that PEG hydrogels that were exposed to UV radia- +tion for longer periods traveled towards the magnets with higher +velocity. The exposure to UV induces the formation of free radi- +cals, wh","[588, 176, 1101, 849]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,text,"The fabrication of magnetically responsive hydrogels crosslinked with paramagnetic ions has also been pursued [48]. Typically, a","[589, 848, 1099, 899]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,image,,"[77, 925, 1086, 1362]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +6,7,figure_title,"Figure 2. Sequential magnetic fusion for the formation of a cartilage construct. (A) Sixteen spheroid aggregates were formed through the use of a network of magnetic tips, which were then placed in co","[80, 1386, 1080, 1489]",figure_caption,0.92,"[""figure_title label: Figure 2. Sequential magnetic fusion for the formation of a ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,8,number,558,"[71, 1529, 110, 1549]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,9,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877, 1533, 1095, 1552]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[402, 99, 1007, 124]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header,Review,"[1031, 93, 1128, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,"correlation between the concentration of the paramagnetic ions and magnetic field gradient can be achieved. In an externally applied magnetic field, the paramagnetic hydrogel spheres assemble into ord","[111, 176, 622, 345]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,Another promising tissue engineering methodology where a 3D tissue is constructed without artificial scaffolds is the magnetically induced cell sheet technology (TABLE 1). MNPs can label specific cell,"[112, 344, 622, 1018]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"The use of external magnetic fields present some limitations, namely the targeting challenge of deep tissues as the targeting efficiency depends on the distance between the magnet and the tissue of in","[112, 1017, 623, 1400]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"effect of labeling stem cells with MNPs. They induce mechani- +cal stimulation through different mechanisms, namely magnetic +twisting, mechanosensitive ion channel activation, targeted ion +channel acti","[633, 176, 1145, 320]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Furthermore, the mechanical stimulation induced by magnetic forces has also been shown to produce significant effects on cells, increasing their metabolic activity during the stimulation period [55]. ","[113, 1401, 623, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"pi p y +general, no adverse effects are found. +Wu et al. demonstrated an enhancement of mitochondrial +activity and expression of bone-related genes in human bone +marrow MSCs adhered to iron-containing ","[633, 320, 1145, 825]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"The feasibility of mechanical stimulation induced by magnetic forces has been shown to promote osteogenic and chondrogenic differentiation of MSCs [28,29] and to promote the organization of endothelia","[634, 824, 1144, 997]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,paragraph_title,Imaging & biosensing functionalities in tissue-engineered substitutes,"[635, 1015, 1062, 1064]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Imaging & biosensing functionalities in tissue-engineered su""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,10,text,"Major achievements in tissue engineering and regenerative medicine therapies are expected from a major challenge in nanomedicine, which consists of integrating selective targeting, imaging and directe","[633, 1065, 1145, 1500]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,footer,www.expert-reviews.com,"[114, 1534, 328, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,12,number,559,"[1103, 1529, 1142, 1550]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Review,"[88, 94, 182, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,"Santo, Rodrigues & Gomes","[207, 98, 458, 121]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,2,image,,"[80, 184, 552, 1049]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +8,3,figure_title,"Figure 3. Endothelial cell organization in magnetic nanoparticle–alginate and alginate constructs. After the seeding into the MNP or alginate scaffold, the endothelial cells were exposed to an alterna","[79, 1076, 568, 1337]",figure_caption,0.92,"[""figure_title label: Figure 3. Endothelial cell organization in magnetic nanopart""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,4,text,"to lesion tissue [60], optical detectability and therapeutic delivery, as mentioned before.","[69, 1353, 574, 1400]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"The application of MNPs in MRI-based technologies is envisioned to improve spatial resolution and soft tissue contrast at a nanoscale level, while simultaneously imaging tissue anatomy, physiology and","[68, 1401, 577, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"biomaterial systems. The detectability of MRI can be signifi- +cantly improved by the preferential accumulation of MNP contrast +agents if the targeting ligands, such as a protein or an antibody, are +at","[589, 175, 1099, 585]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,text,"SPMNs were described to be preferred to gadolinium chelates for cell labeling because they provide high signal contrasts in T2/T2*-weighted image sequences, are nontoxic and biodegradable [61].","[589, 585, 1098, 680]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"In the particular field of tissue engineering, MNPs hold great promise as a detection method for cell selection, cell sorting, spatial control of target cells and cell aggregation and adherence proper","[589, 681, 1099, 849]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,text,"Tracking of implanted cells in regenerative medicine strategies is critical to evaluate cell migration and cellular functions, and to help guide treatment for maximized therapeutic effect [62]. Magnet","[590, 849, 1098, 1185]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,text,The work of Bulte et al. was pioneer on the development of magnetodendrimers for labeling of stem and progenitor cells through a nonspecific membrane adsorption process with a subsequent intracellular,"[590, 1185, 1098, 1352]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,11,text,"The group of Chien Ho has also explored the possibility of using MRI to noninvasively monitor individual immune cells, primarily macrophages in vivo, after heart and lung transplantation $ [65] $. Th","[589, 1353, 1099, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,number,560,"[72, 1529, 110, 1549]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,13,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877, 1532, 1095, 1553]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403, 99, 1007, 124]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,Review,"[1031, 94, 1128, 122]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,2,text,"to complement biopsy is highly desirable. This technique may also be applied to assess the inflammatory response to implanted constructs in tissue engineering strategies, allowing the in situ monitori","[112, 177, 622, 272]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"Several protocols have already been described for in vivo tracking of human skeletal muscle cells [66]. Other protocols use cells as a circulating vehicle; for instance, erythrocytes have been explore","[112, 273, 622, 631]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"Other studies on MSC tracking in limb ischemia revealed MNPs' low toxicity and MSC detection after transplantation $ [68] $. In a rabbit osteochondral model, alginate-incorporated MNPs guided by exte","[113, 632, 622, 849]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,text,"Some pioneer studies on the design techniques of these multimodal nanoparticles have already been published. Zhu et al. developed probes combining magnetic, fluorescence and thermoresponsive features ","[112, 848, 623, 1211]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,paragraph_title,Biosensing,"[115, 1233, 216, 1255]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Biosensing""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +9,7,text,"The rapid and sensitive detection of molecular targets such as genetic material, proteins, enzymes, cytokines, growth factors, pathogens and metabolic byproducts secreted by cells is a major point in ","[112, 1256, 622, 1377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,text,The detection and measurement of biomolecules in the culture medium where cell-laden tissue engineering systems are cultured gathers relevant information on in vitro cell behavior and thus of the tiss,"[113, 1377, 623, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,text,"methodologies. MNPs are also envisioned to play a role in the +detection, labeling and selective elimination of pathogens poten- +tially present in a culture medium or targeted antibacterial ther- +apy t","[634, 176, 1144, 369]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,10,text,"By incorporating advanced features, the detectability and applicability of MNPs have been dramatically expanded. Nevertheless, the location, distribution and long-term viability of tagged cells for cl","[634, 368, 1145, 512]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,11,text,Preclinical assays for cardiac applications are already being performed. Subcutaneous sensors were implanted in rodents for noninvasive measuring cardiac-specific biomarker levels in an attempt to pre,"[633, 513, 1145, 682]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,12,paragraph_title,Remote-controlled therapies,"[636, 705, 893, 726]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Remote-controlled therapies""]",subsection_heading,0.6,body_zone,body_like,none,True,True +9,13,text,"Magnetic field therapies, often referred as pulsed electromagnetic field (PEMF) therapies, are already applied in clinical practice to promote bone healing in delayed unions and nonunions $ [71] $ wi","[634, 729, 1144, 920]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,14,text,"Pilot clinical trials also indicate the beneficial effects of PEMF on pain relief $ [73,75,76] $, in particular the rapid impact on pain reduction from early knee osteoarthritis $ [75] $ or osteonec","[634, 920, 1144, 1064]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,15,text,One of the reported effects of this therapy includes the enhancement of metabolic activity of chondrocytes [77–79] and the prevention of the catabolic effects of inflammation [80–84] caused by osteoar,"[634, 1065, 1145, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,16,footer,www.expert-reviews.com,"[115, 1534, 328, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,17,number,561,"[1103, 1529, 1140, 1550]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,"Review Santo, Rodrigues & Gomes","[86, 96, 458, 122]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,image,,"[78, 186, 1090, 421]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,2,figure_title,Figure 4. Magnet-scaffold configurations suggested by Russo et al. (A) External permanent magnetic ring (EM); (B) implanted permanent magnetic pins (PM); (C) implanted stainless steel pins in the fiel,"[79, 439, 1065, 561]",figure_caption,0.92,"[""figure_title label: Figure 4. Magnet-scaffold configurations suggested by Russo ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +10,3,text,"growth factors, including bone morphogenetic proteins and TGF $ [87,88] $. Angiogenesis $ [89,90] $ and mechanical properties $ [91] $ were also reported to be enhanced post-therapy.","[67, 584, 576, 656]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,"Despite the fact that remote-controlled therapies are poorly explored in the fields of cell and tissue engineering, increasing focus has been devoted to explore the remote control applications, includ","[68, 657, 576, 1233]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"PEMF therapies have been already US FDA approved for several pathologies including nonunion bone fractures and arthritic pain, but studies directed to tissue engineering and regenerative medicine stra","[67, 1233, 577, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"would stimulate implantable scaffolds. The incorporation of +MNPs in the scaffolds in combination with PEMF stimulation +would likely result in a synergistic therapeutic effect. In the case +of multifunc","[588, 583, 1099, 945]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,text,"Selective control of cell function by applying time-varying magnetic fields has added a new, exciting dimension to biology and medicine. The ability to remotely control cell or construct fate locally ","[588, 944, 1099, 1138]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,paragraph_title,Expert commentary,"[591, 1161, 779, 1183]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Expert commentary""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,9,text,"Besides sorting and isolation abilities, MNPs may also be used as pulsatile delivery systems for the release of selected growth factors. Magnetism is acknowledged as an advantageous physical stimulus ","[588, 1185, 1100, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,number,562,"[72, 1529, 110, 1549]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,11,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877, 1532, 1095, 1553]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403, 99, 1006, 124]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header,Review,"[1032, 94, 1127, 122]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,2,text,Probably the most challenging and innovative aspects of magnetic-based approaches consist of the integration of the theranostic tools provided by the MNPs into a 3D tissue-engineered construct as well,"[114, 177, 621, 323]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,3,paragraph_title,Five-year view,"[115, 345, 253, 367]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Five-year view""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,4,text,"The increased number of literature reports shows a clear tendency for a significant increase in research focusing on magnetic responsive systems and their potential in the regenerative medicine field,","[113, 368, 621, 464]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"To fabricate 3D magnetic responsive tissue-engineered constructs with precisely controlled architectures, the ability to assemble cell-laden microscale magnetic hydrogels (M-gels) should be further ex","[114, 465, 621, 607]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,Research in this field is also expected to further explore the ability of magnetic systems to promote the release of relevant molecules through a magnetic switch on/off and their role on stem cell dev,"[115, 609, 622, 658]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"molecules through a magnetic switch on/off and their role on stem +cell development as well as the ability for the ex vivo stimulation +of implanted devices.","[636, 177, 1143, 247]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,8,text,"Finally, a great deal of attention is also expected to be directed to the clarification of the long-term fate of embedded MNPs before considering the clinical application of magnetic tissue-engineered","[636, 249, 1144, 343]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"In summary, in upcoming years, several advances are expected that will revolutionize the field as they hold the potential to overcome main obstacles to the routine use of tissue engineering therapies ","[636, 345, 1144, 443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,paragraph_title,Financial & competing interests disclosure,"[636, 465, 986, 487]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Financial & competing interests disclosure""]",subsection_heading,0.6,body_zone,body_like,none,True,True +11,11,text,The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in ,"[636, 491, 1145, 632]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,12,text,No writing assistance was utilized in the production of this manuscript.,"[653, 634, 1141, 657]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,13,paragraph_title,Key issues,"[121, 695, 225, 720]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Key issues""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,14,text,• Magnetic nanoparticles (MNPs) allow the development of magnetic responsive tissue-engineered systems that may enable pulsatile delivery of growth factors while simultaneously allowing magnetic stimu,"[120, 730, 1107, 794]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,15,text,• Magnetic responsive tissue-engineered systems may be obtained by direct incorporation of the MNPs into a 3D scaffold or hydrogel or by association of MNPs with stem cells that are subsequently seede,"[122, 797, 1129, 840]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,16,text,"• Magnetic responsive systems may allow simultaneous diagnostic and therapeutic functionalities; therapeutic functionalities include the possibility to enhance stem cells response, tailoring their loc","[120, 843, 1134, 993]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,17,paragraph_title,References,"[116, 1041, 220, 1062]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +11,18,reference_content,"Papers of special note have been highlighted as: +• of interest","[116, 1065, 422, 1106]",reference_item,0.85,"[""reference content label: Papers of special note have been highlighted as:\n\u2022 of intere""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +11,19,reference_content,•• of considerable interest,"[117, 1105, 286, 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From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering. Nanomedicine (Lo","[116, 1130, 435, 1255]",reference_item,0.85,"[""reference content label: 1 Santo VE, Gomes ME, Mano JF, Reis RL. From nano- to macro-""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +11,21,reference_content,"2 Li Y, Huang G, Zhang X et al. Magnetic hydrogels and their potential biomedical applications. Adv. Funct. Mater. 23(6), 660–672 (2013).","[115, 1263, 426, 1345]",reference_item,0.85,"[""reference content label: 2 Li Y, Huang G, Zhang X et al. Magnetic hydrogels and their""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +11,22,reference_content,"3 Santo VE, Duarte AR, Popa EG, Gomes ME, Mano JF, Reis RL. 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Sci. Eng., Just Accepted Manuscript • DOI: 10.1021/acsbiomaterials.9b00858 • Publication Date (Web): 03 Sep 2019","[308, 369, 874, 414]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: ACS Biomater. Sci. Eng., Just Accepted Manuscript \u2022 DOI: 10.""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,7,text,"Downloaded from pubs.acs.org on September 3, 2019","[361, 420, 831, 445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,8,paragraph_title,Just Accepted,"[124, 515, 281, 541]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Just Accepted""]",frontmatter_noise,0.8,frontmatter_main_zone,heading_like,short_fragment,False,False +1,9,abstract,"“Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemic","[132, 564, 1058, 883]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,False,True +1,10,footer,"is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036","[591, 1562, 1071, 1595]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,11,footer,"Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth","[590, 1597, 1113, 1665]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[8, 90, 44, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,1,number,Page 1 of 36,"[12, 18, 122, 44]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,doc_title,3D-printed $ \beta $-tricalcium phosphate scaffold combined with a pulse electromagnetic field promotes the repair of skull defects in rats,"[191, 182, 1000, 344]",unknown_structural,0.8,"[""page-1 zone title_zone: 3D-printed $ \\beta $-tricalcium phosphate scaffold combined""]",paper_title,0.8,body_zone,body_like,none,False,True +2,4,text,"Haifeng Liang $ ^{a} $, Xiao Liu $ ^{b} $, Ying Pi $ ^{a} $, Qiang Yu $ ^{a} $, Yukun Yin $ ^{a} $, Xian Li $ ^{a} $, Yipei Yang $ ^{a} $, Jing Tian $ ^{*a} $","[174, 380, 946, 408]",unknown_structural,0.8,"[""page-1 zone author_zone: Haifeng Liang $ ^{a} $, Xiao Liu $ ^{b} $, Ying Pi $ ^{a} $,""]",authors,0.8,body_zone,body_like,none,False,True +2,5,text,"a Department of Orthopedics, Zhujiang Hospital, Southern Medical University, No. 253 Industrial Avenue, Haizhu, Guangzhou 510280, People's Republic of China","[174, 443, 1015, 533]",affiliation,0.8,"[""page-1 zone affiliation_zone: a Department of Orthopedics, Zhujiang Hospital, Southern Med""]",affiliation,0.8,body_zone,body_like,none,True,True +2,6,text," $ ^{b} $ School of Materials Science and Engineering, South China University of Technology, Wushan, +Guangzhou 510640, People's Republic of China","[173, 568, 1015, 657]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{b} $ School of Materials Science and Engineering, South ""]",affiliation,0.8,body_zone,body_like,affiliation_marker,True,True +2,7,text,"*Corresponding author: Jing Tian, Email: tianjing_ortho@163.com","[176, 693, 748, 720]",frontmatter_support,0.78,"[""first-surviving-page support text: *Corresponding author: Jing Tian, Email: tianjing_ortho@163.""]",frontmatter_support,0.78,frontmatter_side_zone,support_like,none,True,True +2,8,paragraph_title,ABSTRACT,"[175, 815, 277, 842]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_side_zone,heading_like,short_fragment,True,True +2,9,abstract,"Trauma, infection, cancer and congenital diseases can lead to bone defects. The combination of 3D printing with biomaterials is of great significance in the treatment of bone defects. In addition, pul","[174, 880, 1017, 1533]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +2,10,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 85, 42, 1532]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +3,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,number,Page 2 of 36,"[1069, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,3,text,"proliferation and differentiation of rADSCs and the repair of a critical defect in the rat skull. +Therefore, the combination of $ \beta $-TCP and PEMF with 3D printing technology can provide better +t","[175, 164, 1015, 316]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,KEYWORDS: 3D printing; $ \beta $-tricalcium phosphate; pulse electromagnetic field; bone defect,"[175, 476, 953, 502]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +3,5,paragraph_title,INTRODUCTION,"[176, 664, 311, 687]",section_heading,0.9,"[""explicit scholarly heading: INTRODUCTION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,6,text,Pulse electromagnetic fields (PEMFs) are transient electromagnetic fields produced in a coil when a pulse current generated by a pulse generator passes through the coil. The strength and frequency of ,"[173, 726, 1017, 1503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 90, 44, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +4,1,number,Page 3 of 36,"[12, 18, 121, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 46]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,3,text,"PEMFs have a ""window effect"" $ ^{39} $; that is, the field strength, frequency and action time of PEMFs do not have linear relationships with the biological effects observed in cells. The field streng","[171, 162, 1019, 1504]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 84, 42, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +5,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,number,Page 4 of 36,"[1069, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,3,text,"nonunion and other orthopedic diseases, it is rarely used to treat bone defects. Prior to this study, we demonstrated that PEMF therapy (50 Hz, 1 mT) can promote the proliferation and osteogenic diffe","[174, 166, 1017, 441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"The treatment of bone defects has always been a clinical problem, and the gold standard for treatment is autografts. However, bone transplantation has disadvantages such as few available sources, a la","[173, 476, 1017, 1504]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10, 90, 42, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +6,1,number,Page 5 of 36,"[13, 18, 121, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 763, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,text,"also contains a porous structure design and rapid prototyping technology to provide space for +osteoblast growth and vascular formation and to shorten the whole transplantation process. The +combination","[175, 166, 1016, 380]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,paragraph_title,MATERIALS AND METHODS,"[176, 539, 423, 562]",section_heading,0.9,"[""explicit scholarly heading: MATERIALS AND METHODS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +6,5,paragraph_title,Fabrication and characterization of $ \beta $-TCP scaffolds,"[176, 601, 626, 625]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Fabrication and characterization of $ \\beta $-TCP scaffolds""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +6,6,text,"The β-TCP scaffolds were fabricated as previously described $ ^{33} $. Briefly, β-TCP powder was prepared using the chemical precipitation method. Then, ammonium polyacrylate (PAA-NH4) and hydroxyprop","[174, 663, 1016, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10, 85, 41, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +7,1,header,ACS Biomaterials Science & Engineering,"[425, 19, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,number,Page 6 of 36,"[1069, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,3,text,"volume of the $ \beta $-TCP scaffolds was reduced to 90% after sintering. The design of the scaffold was completed by the CAD software SolidWorks (Massachusetts, USA). The scaffold was coated with go","[174, 164, 1015, 317]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,paragraph_title,Cell culture and PEMF treatment,"[176, 352, 470, 376]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell culture and PEMF treatment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,5,text,"ADSCs were obtained from the groin of 3-day-old Sprague Dawley rats. The cells were cultured on Dulbecco's minimum Eagle's medium (DMEM, Gibco) with 10% fetal bovine serum (FBS, Gibco) and 5% antibiot","[174, 415, 1016, 628]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"The prepared cells were randomly divided into four groups and seeded on tissue culture plates (TCPS) or $ \beta $-TCP scaffolds. The LIVE/DEAD Cell Staining Kit (BioVision, Inc.) was applied to rADSC","[173, 665, 1016, 940]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"The PEMF device (Yongyikeji, Hunan, China) consisted of a generator and its connected coils. When the generator produces a pulse current of a certain intensity, a PEMF will be generated between the co","[173, 977, 1016, 1377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,CCK-8 and LIVE/DEAD cell staining,"[176, 1475, 480, 1499]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: CCK-8 and LIVE/DEAD cell staining""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,9,footer,ACS Paragon Plus Environment,"[463, 1602, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 91, 44, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +8,1,number,Page 7 of 36,"[13, 18, 121, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"The CCK-8 assay was performed to evaluate the proliferation of ADSCs under the influence of PEMF and the scaffolds. rADSCs were cultured in basic culture medium for 1, 4 or 7 days on TCPS and $ \beta","[173, 165, 1016, 563]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"LIVE/DEAD cell staining was performed to evaluate the cytotoxicity of the $ \beta $-TCP scaffolds. Each scaffold was washed twice with PBS after 24, 48 and 72 hours, before the working solution was a","[174, 601, 1016, 878]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,paragraph_title,ALP activity and osteogenesis - related gene expression,"[175, 913, 661, 938]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: ALP activity and osteogenesis - related gene expression""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +8,6,text,"To evaluate the osteogenic differentiation of ADSCs, cellular ALP activity was accessed with an alkaline phosphatase assay kit (A059-1, Nanjing Jiancheng Bioengineering Institute, China) after 7 or 14","[174, 978, 1017, 1503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 86, 42, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +9,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,2,number,Page 8 of 36,"[1069, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,3,text,"was completed with the cALP Stain Kit (D001-1-1, Nanjing Jiancheng Bioengineering Institute, +China).","[174, 164, 1015, 254]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"The expression of osteogenesis-related genes in the four groups was evaluated by SYBR +Green Real-Time PCR (Thermo Fisher Scientific, Waltham, MA, USA). Total RNA of the ADSCs of +the four groups was is","[173, 289, 1017, 818]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,figure_title,Table 1. Primer sequences used for qRT-PCR.,"[197, 851, 587, 877]",table_caption,0.9,"[""table prefix matched: Table 1. Primer sequences used for qRT-PCR.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,6,table,
GeneForward(5′-3′)Reverse(5′-3′)
ALPACCATTCCCACGTCTTCACATTTAGACATTCTCTCGTTCACCGCC
RUNX2ACTTCCTGTGCTCGGTGCT,"[204, 911, 979, 1110]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,unknown_like,none,True,True +9,7,paragraph_title,Surgical operation and PEMF treatment,"[175, 1163, 529, 1188]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Surgical operation and PEMF treatment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,8,text,All the surgical operations were approved by the Ethics Committee of Southern Medical University. Eighteen female Sprague-Dawley rats (180-200 g) were anesthetized with chloral hydrate (300 mg/kg body,"[173, 1225, 1017, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 89, 42, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +10,1,number,Page 9 of 36,"[13, 18, 121, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,3,text,"mm, on both sides of the parietal bone; physiological saline was added dropwise to help reduce the increase in temperature from the drill. A size matched scaffold, with a diameter of 4.8 mm and a heig","[173, 166, 1017, 441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,"On the third day after the operation, the 18 SD rats were randomly divided into 2 groups. One group was treated with PEMF (50 Hz, 1 mT, 2 hours per day), and the other group, as a control, did not rec","[173, 476, 1017, 877]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,paragraph_title,Micro-CT,"[175, 912, 264, 936]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Micro-CT""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,6,text,The skulls were placed into an X-ray CT scanner for experimental animals (Latheta LCT-200) and scanned with a resolution of 18 $ \mu $m. DICOM images were obtained. Bone mineral density was analyzed ,"[173, 975, 1017, 1249]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,paragraph_title,Histological examination,"[176, 1288, 400, 1313]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histological examination""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +10,8,text,"The free skulls were fixed with formalin for 24 hours and then decalcified with EDTA decalcifying solution (Solarbio, China) for 14 days. The decalcified samples were dehydrated by gradient alcohol an","[173, 1349, 1017, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,9,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[11, 89, 41, 1517]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +11,1,header,ACS Biomaterials Science & Engineering,"[426, 19, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,2,number,Page 10 of 36,"[1060, 18, 1178, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,3,text,tissue sections. Hematoxylin-eosin staining of the sections was used to stain the nucleus blue and the cytoplasm red.,"[174, 164, 1014, 253]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,paragraph_title,Statistics,"[176, 289, 262, 312]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Statistics""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,5,text,The statistical analyses of this study were completed with SPSS software (Version 20.0). All biological experiments in this study were repeated at least three times. The data were analyzed by one-way ,"[174, 352, 1015, 568]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,paragraph_title,RESULTS AND DISCUSSION,"[176, 725, 415, 749]",section_heading,0.9,"[""explicit scholarly heading: RESULTS AND DISCUSSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +11,7,paragraph_title,β-TCP scaffold characterization,"[176, 788, 454, 812]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: \u03b2-TCP scaffold characterization""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +11,8,text,"The surface morphology of the fritted β-TCP scaffolds was observed by SEM (Figure 1a and 1b.), which showed that the structure of the scaffolds was arranged regularly with a bar that was 170±10 μm in ","[173, 851, 1017, 1252]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"The $ \beta $-TCP scaffolds produced by 3D printing technology had great porosity. This property can provide a large number of adhesion areas for cells. When used as a graft, high porosity scaffolds ","[174, 1289, 1015, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 92, 42, 1517]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +12,1,number,Page 11 of 36,"[12, 18, 131, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,3,vision_footnote,beneficial for osteogenesis and angiogenesis.,"[177, 163, 566, 189]",footnote,0.7,"[""vision_footnote label: beneficial for osteogenesis and angiogenesis.""]",footnote,0.7,body_zone,body_like,none,True,True +12,4,image,,"[178, 206, 588, 560]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,5,image,,"[598, 206, 1011, 559]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,6,image,,"[179, 574, 590, 922]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,7,image,,"[599, 570, 1010, 922]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,8,figure_title,"Figure 1. SEM images of 3D-printed β-TCP scaffolds: the top panels are (a) 100×, (b) 240× and show that the diameter of the bar is approximately 170±10 microns. The bars are arranged vertically, which","[173, 943, 1016, 1159]",figure_caption,0.92,"[""figure_title label: Figure 1. SEM images of 3D-printed \u03b2-TCP scaffolds: the top ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +12,9,paragraph_title,LIVE/DEAD staining,"[175, 1256, 354, 1283]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: LIVE/DEAD staining""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +12,10,text,"To determine the cytocompatibility and cytotoxicity of the scaffolds, we performed the LIVE/DEAD cell staining assay. As the results show (Figure 2.), living cells were dyed green, and dead cells were","[173, 1319, 1017, 1534]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,11,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 84, 41, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +13,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,2,number,Page 12 of 36,"[1059, 18, 1178, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,3,text,"morphology of the rADSCs attached to the scaffold was observed. The ratios of live/dead rADSCs at 24, 48 and 72 hours were 4.36 (Figure 2a, 109/25), 5.81 (Figure 2b, 343/59) and 7.60 (Figure 2c, 251/3","[172, 164, 1017, 441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,image,,"[244, 463, 624, 733]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,5,image,,"[635, 464, 1011, 732]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,6,image,,"[188, 742, 625, 1011]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,7,image,,"[633, 744, 1012, 1012]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,8,image,,"[244, 1022, 624, 1291]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,9,image,,"[634, 1023, 1011, 1291]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,10,figure_title,"Figure 2. LIVE/DEAD staining of rADSCs cultured on scaffolds in ordinary medium for 24, 48 or 72 hours. Live cells are stained green and dead cells are stained red. In the low power field of vision, t","[173, 1318, 1019, 1533]",figure_caption,0.92,"[""figure_title label: Figure 2. LIVE/DEAD staining of rADSCs cultured on scaffolds""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +13,11,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[9, 95, 42, 1515]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +14,1,number,Page 13 of 36,"[12, 18, 130, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,2,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,3,text,"of culture time. In the high-power field of vision, the living cells exhibit a state of expansion in the early stage (b) and elongation in the later stage (f).","[173, 164, 1015, 254]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,4,paragraph_title,CCK-8 assay,"[175, 351, 288, 378]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: CCK-8 assay""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +14,5,text,"As shown in Figure 3, after one day of culture, the proliferation rate of the rADSCs cultured on the scaffold was significantly higher than that of the cells cultured on TCPS, but PEMF treatment had n","[172, 415, 1018, 1317]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,footer,ACS Paragon Plus Environment,"[463, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[9, 87, 42, 1514]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +15,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,2,number,Page 14 of 36,"[1059, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,3,chart,,"[200, 182, 993, 583]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,4,figure_title,"Figure 3. CCK-8 analysis after culture for 1, 4, or 7 days on TCPS or $ \beta $-TCP scaffolds. After 1 day of culture, the proliferation rate of rADSCs cultured on $ \beta $-TCP scaffolds was signif","[172, 631, 1016, 1037]",figure_caption,0.92,"[""figure_title label: Figure 3. CCK-8 analysis after culture for 1, 4, or 7 days o""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +15,5,paragraph_title,ALP activity and osteogenesis-related gene expression,"[175, 1132, 656, 1157]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: ALP activity and osteogenesis-related gene expression""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +15,6,text,"ALP activity and ALP staining were used to assess the osteogenic differentiation of rADSCs in the four groups after 14 days of culture. As shown in Figure 4., the ALP activity of the $ \beta $-TCP+PE","[173, 1194, 1018, 1472]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,7,footer,ACS Paragon Plus Environment,"[463, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59","[8, 94, 44, 1514]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +16,1,number,Page 15 of 36,"[12, 18, 131, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,3,chart,,"[198, 181, 995, 648]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,4,figure_title,"Figure 4. ALP activity analysis of rADSCs after culture in osteogenic induction medium for 14 days. The activity of ALP in the TCPS+PEMF and $ \beta $-TCP groups was similar, and a significant differ","[173, 693, 1017, 973]",figure_caption,0.92,"[""figure_title label: Figure 4. ALP activity analysis of rADSCs after culture in o""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +16,5,text,"Areas of positive ALP staining are shown as purple. As seen from Figure 5a and 5c, the positive area of the TCPS+PEMF group is more disperse than that of the TCPS group, and the coloration is deeper. ","[174, 1070, 1016, 1344]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,footer,ACS Paragon Plus Environment,"[463, 1601, 727, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[8, 83, 44, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +17,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 765, 46]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,2,number,Page 16 of 36,"[1059, 18, 1179, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,3,image,,"[190, 158, 661, 398]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,4,image,,"[673, 156, 1012, 396]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,5,image,,"[323, 408, 662, 652]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,6,image,,"[672, 409, 1011, 650]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,7,figure_title,β-TCP,"[348, 688, 421, 720]",figure_caption_candidate,0.85,"[""figure_title label: \u03b2-TCP""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +17,8,figure_title,β-TCP+PEMF,"[742, 687, 890, 720]",figure_caption,0.85,"[""figure_title label: \u03b2-TCP+PEMF""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +17,9,image,,"[179, 751, 593, 1158]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,10,image,,"[610, 750, 1011, 1157]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,11,figure_title,"Figure 5. ALP staining of rADSCs after culture in osteogenic induction medium for 14 days. (a), (b) rADSCs exposed to PEMF and cultured on TCPS. (c), (d) rADSCs not exposed to PEMF and cultured on TCP","[172, 1192, 1016, 1408]",figure_caption,0.92,"[""figure_title label: Figure 5. ALP staining of rADSCs after culture in osteogenic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +17,12,text,qRT-PCR was performed to detect the expression of osteoblast-related genes in cells. As,"[216, 1504, 1016, 1534]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,13,footer,ACS Paragon Plus Environment,"[462, 1600, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +18,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 90, 42, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +18,1,number,Page 17 of 36,"[12, 18, 130, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +18,3,text,"shown in Figure 6a, the mean values of ALP and Runx2 expression were the highest in the $ \beta $-TCP+PEMF group after 7 days of culture, and there were significant differences among the groups. Ther","[174, 166, 1017, 503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,4,text,"On the 14th day (Figure 6b.), the expression of ALP, Runx2 and OPN was highest in the $ \beta $-TCP+PEMF group and was significantly higher than that in the other three groups. The expression of OPN ","[174, 540, 1016, 753]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,5,text,"On the 21st day (Figure 6c.), the expression of ALP, Runx2 and OPN in the $ \beta $-TCP+PEMF group was significantly higher than that in the other three groups, and the expression of ALP and Runx2 in","[174, 788, 1016, 1004]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,6,text,"The ALP activity assay showed that the ALP activity of the cells treated with PEMF was significantly increased, and the ALP activity of the cells treated with PEMF was similar to that of the cells tre","[173, 1039, 1016, 1252]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,7,text,"A study by LeGeros, R $ Z^{32} $ et al. showed that calcium phosphate compounds have the following characteristics: similarity to the composition of bone minerals, ability to form a unique bone-calci","[174, 1289, 1016, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,8,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +19,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10, 84, 41, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +19,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +19,2,number,Page 18 of 36,"[1059, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,3,text,mechanism by which PEMFs can promote osteogenic differentiation is not completely clear. Wang et al. showed that PEMFs could stimulate osteoblast differentiation by stimulating the sAC-cAMP-PKA-CREB s,"[174, 165, 1017, 754]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,4,figure_title,ALP,"[393, 796, 440, 822]",figure_caption,0.85,"[""figure_title label: ALP""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +19,5,chart,,"[196, 824, 587, 1134]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,6,figure_title,Runx2,"[788, 796, 860, 823]",figure_caption_candidate,0.85,"[""figure_title label: Runx2""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +19,7,chart,,"[610, 828, 993, 1133]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,8,figure_title,OPN,"[401, 1160, 451, 1187]",figure_caption,0.85,"[""figure_title label: OPN""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +19,9,chart,,"[196, 1187, 907, 1497]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,10,footer,ACS Paragon Plus Environment,"[463, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +20,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 89, 44, 1529]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +20,1,number,Page 19 of 36,"[13, 18, 131, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +20,3,figure_title,"Figure 6. qRT-PCR analysis was used to evaluate the expression of osteogenesis-related genes in rADSCs cultured in osteogenic induction medium for 7, 14 or 21 days. (a) The expression of ALPin the $ ","[173, 165, 1017, 817]",figure_caption,0.92,"[""figure_title label: Figure 6. qRT-PCR analysis was used to evaluate the expressi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +20,4,paragraph_title,Micro CT scanning and hematoxylin-eosin staining,"[175, 913, 621, 938]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Micro CT scanning and hematoxylin-eosin staining""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +20,5,text,"As shown in Figure 7, the bone defect site of the SD rats not treated with PEMF, especially the side without the scaffold, grew slowly and new bone appeared at the edge of the defect site at the eight","[173, 978, 1016, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,6,text,Osteogenic differentiation and angiogenesis are essential for bone regeneration. In addition,"[216, 1474, 1014, 1501]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,7,footer,ACS Paragon Plus Environment,"[463, 1601, 727, 1626]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +21,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[10, 85, 41, 1532]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +21,1,header,ACS Biomaterials Science & Engineering,"[425, 19, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +21,2,number,Page 20 of 36,"[1059, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,3,text,"to promoting the osteogenic differentiation of stem cells, PEMF therapy can also promote angiogenesis. Yen-Patton, G P $ ^{43} $ et al. used PEMFs to treat endothelial cells of the human umbilical vei","[174, 165, 1017, 567]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,4,footer,ACS Paragon Plus Environment,"[463, 1602, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +22,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[8, 87, 45, 1528]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +22,1,number,Page 21 of 36,"[11, 17, 132, 45]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,2,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +22,3,image,,"[178, 154, 1011, 1130]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +22,4,figure_title,"Figure 7. 3D reconstruction of the imaging data of SD rats after 0, 4, 8 and 12 weeks of rearing. +The rats in the PEMF group were treated with PEMFs for 2 hours per day, whereas the rats in the withou","[173, 1161, 1015, 1315]",figure_caption,0.92,"[""figure_title label: Figure 7. 3D reconstruction of the imaging data of SD rats a""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +22,5,text,"Bone mineral density (BMD) measurements of the new bone were determined in SD rats after 12 weeks. As shown in Figure 8, the highest BMD values were found in the cranial defects","[172, 1412, 1017, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,6,footer,ACS Paragon Plus Environment,"[461, 1600, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +23,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 84, 42, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +23,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +23,2,number,Page 22 of 36,"[1059, 18, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,3,text,"of rats treated with the scaffold and PEMFs. The cranial defect of rats with the scaffold but without PEMF treatment followed closely. The blank group, which did not receive any treatments, had the lo","[174, 164, 1016, 317]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,4,chart,,"[208, 370, 988, 986]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,5,figure_title,Figure 8. Bone mineral density analysis based on micro-CT data was used to detect the growth of skull defects in SD rats after 12 weeks of rearing. The BMD values of the defect site of rats in the $ ,"[173, 1038, 1016, 1314]",figure_caption,0.92,"[""figure_title label: Figure 8. Bone mineral density analysis based on micro-CT da""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +23,6,text,"The results of the HE staining (Figure 9) showed that the implanted scaffold defects possessed good bone mass; however, the rats treated with PEMFs grew thicker bone tissue than","[173, 1412, 1016, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,7,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +24,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 91, 44, 1532]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +24,1,number,Page 23 of 36,"[12, 18, 131, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,2,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +24,3,text,"the rats who had not been treated with PEMFs. In the defect sites without $ \beta $-TCP scaffold implantation, the amount of new bone tissue was reduced, and the new bone tissue structure was more di","[173, 164, 1016, 380]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,4,text,"The BMD results of this study indicate that the BMD values of the defect sites of the rats treated with PEMFs were higher than those of the rats who did not receive PEMF treatment, regardless of wheth","[174, 415, 1017, 878]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,5,footer,ACS Paragon Plus Environment,"[463, 1602, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +25,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 84, 42, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +25,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +25,2,number,Page 24 of 36,"[1059, 18, 1178, 44]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +25,3,image,,"[178, 154, 1010, 426]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,4,image,,"[179, 491, 1010, 766]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,5,image,,"[180, 829, 1009, 1107]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,6,image,,"[179, 1168, 1009, 1444]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +25,7,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +26,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 91, 41, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +26,1,number,Page 25 of 36,"[12, 18, 131, 44]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +26,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 763, 45]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +26,3,image,,"[180, 146, 1010, 770]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +26,4,image,,"[180, 858, 1009, 1478]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +26,5,footer,ACS Paragon Plus Environment,"[463, 1600, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +27,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 84, 44, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,reference_like,reference_numeric_dot,False,False +27,1,header,ACS Biomaterials Science & Engineering,"[425, 17, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +27,2,number,Page 26 of 36,"[1059, 18, 1178, 44]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +27,3,image,,"[180, 145, 1010, 770]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,4,image,,"[179, 856, 1010, 1479]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,5,figure_title,"Figure 9. HE staining of the cranial defects of rats after 12 weeks of rearing. (A), (E) Rats","[173, 1504, 1014, 1532]",figure_caption,0.92,"[""figure_title label: Figure 9. HE staining of the cranial defects of rats after 1""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,True,True +27,6,footer,ACS Paragon Plus Environment,"[461, 1600, 729, 1627]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +28,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 90, 44, 1530]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,reference_zone,reference_like,reference_numeric_dot,False,False +28,1,number,Page 27 of 36,"[12, 18, 131, 44]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,2,header,ACS Biomaterials Science & Engineering,"[426, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +28,3,text,"implanted with a $ \beta $-TCP scaffold and exposed to PEMFs. (B), (F) Rats implanted with a $ \beta $-TCP scaffold and not exposed to PEMFs. (C), (G) Rats exposed to PEMFs. (D), (H) Rats not expose","[175, 163, 1017, 314]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,4,paragraph_title,CONCLUSION,"[176, 475, 301, 500]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +28,5,text,"To summarize, 3D-printed $ \beta $-TCP porous scaffolds have excellent performance in the treatment of skull defects in rats. These scaffolds solve the problems associated with complications and limi","[173, 541, 1018, 1253]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,6,paragraph_title,REFERENCES,"[176, 1411, 293, 1437]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +28,7,reference_content,"(1) Bassett, C. A.; Pawluk, R. J.; Pilla, A. A., Acceleration of fracture repair by electromagnetic","[187, 1474, 1014, 1500]",reference_item,0.85,"[""reference content label: (1) Bassett, C. A.; Pawluk, R. J.; Pilla, A. A., Acceleratio""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_parenthesis,True,True +28,8,footer,ACS Paragon Plus Environment,"[462, 1602, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +29,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[11, 91, 41, 1532]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,reference_zone,reference_like,reference_numeric_dot,False,False +29,1,header,ACS Biomaterials Science & Engineering,"[425, 19, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +29,2,number,Page 28 of 36,"[1060, 19, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +29,3,text,"fields. A surgically noninvasive method. Ann N Y Acad Sci 1974, 238, 242-62","[176, 164, 826, 189]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +29,4,text,"(2) Bassett, C. A.; Mitchell, S. N.; Gaston, S. R., Treatment of ununited tibial diaphyseal fractures with pulsing electromagnetic fields. J BONE JOINT SURG AM 1981, 63, (4), 511-23","[176, 228, 1014, 316]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +29,5,text,"(3) Ryaby, J. T., Clinical effects of electromagnetic and electric fields on fracture healing. 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M.; Rae, H.; Dao, A.; Yong, S.; Ying, V., Pulsed electromagnetic field stimulation for acute tibial shaft fractures: a multicenter, double-blind, randomized tri","[175, 476, 1016, 626]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +29,7,text,"(5) Prakash, D.; Behari, J., Synergistic role of hydroxyapatite nanoparticles and pulsed electromagnetic field therapy to prevent bone loss in rats following exposure to simulated microgravity. 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DOI:10.1016/j.biomaterials.2005.02.002","[175, 476, 1012, 565]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +34,6,text,"(38) Midura, R. J.; Ibiwoye, M. O.; Powell, K. A.; Sakai, Y.; Doehring, T.; Grabiner, M. D.; Patterson, T. E.; Zborowski, M.; Wolfman, A., Pulsed electromagnetic field treatments enhance the healing o","[175, 601, 1015, 752]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +34,7,text,"(39) Parkinson, W. C.; Hanks, C. T., Search for cyclotron resonance in cells in vitro. +BIOELECTROMAGNETICS 1989, 10, (2), 129-45","[175, 788, 1013, 875]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +34,8,text,"(40) Liu, C.; Yu, J.; Yang, Y.; Tang, X.; Zhao, D.; Zhao, W.; Wu, H., Effect of 1 mT sinusoidal electromagnetic fields on proliferation and osteogenic differentiation of rat bone marrow mesenchymal st","[175, 914, 1015, 1128]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +34,9,text,"(41) Tsai, M. T.; Chang, W. H.; Chang, K.; Hou, R. J.; Wu, T. W., Pulsed electromagnetic fields affect osteoblast proliferation and differentiation in bone tissue engineering. BIOELECTROMAGNETICS 2007","[175, 1164, 1015, 1313]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +34,10,text,"(42) Wang, P.; Liu, J.; Yang, Y.; Zhai, M.; Shao, X.; Yan, Z.; Zhang, X.; Wu, Y.; Cao, L.; Sui, B.; Luo, E.; Jing, D. Differential intensity-dependent effects of pulsed electromagnetic fields on RANKL","[176, 1350, 1015, 1500]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +34,11,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +35,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[11, 93, 41, 1525]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,reference_zone,reference_like,reference_numeric_dot,False,False +35,1,header,ACS Biomaterials Science & Engineering,"[426, 19, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +35,2,number,Page 34 of 36,"[1060, 19, 1178, 43]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +35,3,text,"BIOELECTROMAGNETICS 2017, 38, (8), 602-612.DOI:10.1002/bem.22070","[176, 164, 802, 188]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +35,4,text,"(43) Yen-Patton, G. P.; Patton, W. F.; Beer, D. M.; Jacobson, B. S., Endothelial cell response to pulsed electromagnetic fields: stimulation of growth rate and angiogenesis in vitro. J CELL PHYSIOL 19","[175, 228, 1015, 377]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +35,5,text,"(44) Tepper, O. M.; Callaghan, M. J.; Chang, E. I.; Galiano, R. D.; Bhatt, K. A.; Baharestani, S.; Gan, J.; Simon, B.; Hopper, R. A.; Levine, J. P.; Gurtner, G. C., Electromagnetic fields increase in ","[175, 415, 1014, 626]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +35,6,text,"(45) Loh, Q. L.; Choong, C., Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size. TISSUE ENGINEERING PART B-REVIEWS 2013, 19, (6), 485-502. DOI:10.1089/ten.","[175, 664, 1014, 812]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +35,7,text,"(46) Koski, C.; Onuike, B.; Bandyopadhyay, A.; Bose, S., Starch-hydroxyapatite composite bone scaffold fabrication utilizing a slurry extrusion-based solid freeform fabricator. ADDITIVE MANUFACTURING ","[175, 852, 1016, 1001]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_parenthesis,True,True +35,8,footer,ACS Paragon Plus Environment,"[463, 1603, 728, 1626]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +36,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[8, 91, 44, 1532]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,reference_zone,reference_like,reference_numeric_dot,False,False +36,1,number,Page 35 of 36,"[12, 18, 132, 44]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +36,2,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 46]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +36,3,text,Table of Contents graphic,"[480, 287, 712, 317]",table_caption_candidate,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'table_caption_like' overrides body_paragraph"", ""style_family_authority=table_marker"", ""context_source=families""]",body_paragraph,0.6,,table_caption_like,none,True,True +36,4,doc_title,3D-printed $ \beta $-tricalcium phosphate scaffold combined with a pulse electromagnetic field promotes the repair of skull defects in rats,"[204, 349, 985, 441]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,,unknown_like,none,False,True +36,5,text,"Haifeng Liang, Xiao Liu, Ying Pi, Qiang Yu, Yukun Yin, Xian Li, Yipei Yang, Jing Tian","[245, 474, 946, 503]",frontmatter_noise,0.7,"[""keyword-like block: Haifeng Liang, Xiao Liu, Ying Pi, Qiang Yu, Yukun Yin, Xian ""]",frontmatter_noise,0.7,,unknown_like,none,False,False +36,6,image,,"[221, 554, 943, 884]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +36,7,vision_footnote,Skull Defects Model in S-D Rat,"[285, 814, 583, 879]",footnote,0.7,"[""vision_footnote label: Skull Defects Model in S-D Rat""]",footnote,0.7,,unknown_like,none,True,True +36,8,vision_footnote,"3D-Printed +β-TCP Scaffold","[683, 816, 896, 883]",footnote,0.7,"[""vision_footnote label: 3D-Printed\n\u03b2-TCP Scaffold""]",footnote,0.7,,unknown_like,none,True,True +36,9,image,,"[303, 938, 587, 1088]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +36,10,image,,"[617, 933, 860, 1094]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +36,11,vision_footnote,PEMF Generator,"[351, 1100, 594, 1136]",footnote,0.7,"[""vision_footnote label: PEMF Generator""]",footnote,0.7,,unknown_like,short_fragment,True,True +36,12,image,,"[634, 1102, 878, 1191]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +36,13,vision_footnote,20ms,"[669, 1167, 729, 1190]",footnote,0.7,"[""vision_footnote label: 20ms""]",footnote,0.7,,unknown_like,short_fragment,True,True +36,14,image,,"[269, 1224, 539, 1422]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +36,15,vision_footnote,The rat exposed to PEMF,"[245, 1428, 577, 1460]",footnote,0.7,"[""vision_footnote label: The rat exposed to PEMF""]",footnote,0.7,,unknown_like,none,True,True +36,16,image,,"[674, 1224, 925, 1425]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +36,17,vision_footnote,The rat not exposed to PEMF,"[608, 1428, 994, 1460]",footnote,0.7,"[""vision_footnote label: The rat not exposed to PEMF""]",footnote,0.7,,unknown_like,none,True,True +36,18,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +37,0,aside_text,"1 +2 +3 +4 +5 +6 +7 +8 +9 +10 +11 +12 +13 +14 +15 +16 +17 +18 +19 +20 +21 +22 +23 +24 +25 +26 +27 +28 +29 +30 +31 +32 +33 +34 +35 +36 +37 +38 +39 +40 +41 +42 +43 +44 +45 +46 +47 +48 +49 +50 +51 +52 +53 +54 +55 +56 +57 +58 +59 +60","[9, 86, 42, 1532]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,reference_zone,reference_like,reference_numeric_dot,False,False +37,1,header,ACS Biomaterials Science & Engineering,"[425, 18, 764, 45]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +37,2,number,Page 36 of 36,"[1059, 18, 1178, 44]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +37,3,text,For Table of Contents Use Only,"[456, 163, 735, 190]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +37,4,footer,ACS Paragon Plus Environment,"[462, 1601, 728, 1627]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/2AGGSMVQ/block_trace.csv b/tests/fixtures/ocr_real_papers/2AGGSMVQ/block_trace.csv new file mode 100644 index 00000000..cf6e78d0 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/2AGGSMVQ/block_trace.csv @@ -0,0 +1,134 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,doc_title,A Pulsing Electric Field (PEF) Increases Human Chondrocyte Proliferation through a Transduction Pathway Involving Nitric Oxide Signaling,"[66, 64, 1077, 139]",paper_title,0.8,"[""page-1 zone title_zone: A Pulsing Electric Field (PEF) Increases Human Chondrocyte P""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,1,text,"Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ James Kronberg, $ ^{2} $ Timothy Ganey, $ ^{3} $ Arthur A. Pilla $ ^{4} $","[67, 170, 833, 195]",frontmatter_noise,0.7,"[""keyword-like block: Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ ""]",frontmatter_noise,0.7,body_zone,reference_like,citation_line,False,False +1,2,text," $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite E, Loma Linda, California 92354, $ ^{2} $Healthonics, Inc., Atlanta, Georgia, $ ^{3} $Department of Orthopedic Surgery, Atlanta Medical C","[66, 207, 1079, 269]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,3,text,Received 12 June 2007; accepted 18 October 2007,"[66, 278, 416, 298]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received 12 June 2007; accepted 18 October 2007""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,4,text,Published online 31 January 2008 in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jor.20590,"[66, 298, 839, 318]",frontmatter_noise,0.7,"[""frontmatter noise text: Published online 31 January 2008 in Wiley InterScience (www.""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,5,abstract,"ABSTRACT: A potential treatment modality for joint pain due to cartilage degradation is electromagnetic fields (EMF) that can be delivered, noninvasively, to chondrocytes buried within cartilage. A pu","[67, 333, 1080, 614]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,6,text,Keywords: pulsing electric field; chondrocytes; DNA content; nitric oxide; cGMP,"[67, 628, 686, 650]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: pulsing electric field; chondrocytes; DNA content;""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,7,text,"To provide patients with more treatment options for pain management, especially as the population ages, there is a growing need for new methods, drugs, and devices. $ ^{1} $ Joint pain due to injury, ","[66, 691, 558, 828]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,Cartilage tissue has limited capacity for repair following injury. Untreated defects in the cartilage layer of a joint heal poorly or do not heal at all. The tissue degradation that ensues leads inevi,"[65, 829, 559, 1034]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,text,"Noninvasive electromagnetic fields have been shown to reduce musculoskeletal pain and edema with no known side effects. $ ^{5} $ Recently, a capacitively coupled pulsing electric field (PEF) signal ha","[65, 1034, 559, 1309]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,10,text,It is well known that PEMF signals of the type produced by BGS devices can have a physiologically significant effect on tissue growth and repair in animal studies $ ^{7} $ and human clinical trials. $,"[65, 1310, 560, 1381]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,text,"studies7 and human clinical trials.8 Based on these +reports it was hypothesized that PEF signals may be able +to modulate chondrocyte proliferation. It is thus the +primary intent of this study to test ","[583, 688, 1079, 805]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,12,text,It was considered equally important to determine a possible biological pathway by which the PEF signal could exert its action on chondrocytes. This would help establish a set of criteria by which prop,"[583, 806, 1080, 1105]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,13,paragraph_title,MATERIALS AND METHODS,"[586, 1126, 864, 1148]",section_heading,0.9,"[""explicit scholarly heading: MATERIALS AND METHODS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,14,text,"Majority of reagents were purchased from Sigma (St. Louis, MO) such as culture media (DMEM, #MT10013CV), calf serum (#B14-401F), and L-NAME (#72760) for inhibition of nitric oxide synthase, LY82583 (#","[583, 1150, 1078, 1341]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,paragraph_title,Cell Culture,"[585, 1363, 691, 1383]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Cell Culture""]",section_heading,0.5,body_zone,body_like,short_fragment,True,True +1,16,text,"Normal human chondrocytes (#CC2550) were obtained from Clonetics subdivision of Lonza (Walkersville, MD). Chondrocytes were grown for expansion in 100-mm culture dishes using DMEM supplemented with 5%","[583, 1384, 1079, 1471]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,footnote,Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909-478-9015; E-mail: biocore1@aol.com),"[66, 1406, 558, 1446]",frontmatter_support,0.75,"[""page-1 correspondence footnote: Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909""]",frontmatter_support,0.75,body_zone,body_like,none,True,True +1,18,footnote,"© 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.","[68, 1449, 559, 1471]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2008 Orthopaedic Research Society. Published by Wiley Peri""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,19,number,854,"[69, 1478, 105, 1497]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +1,20,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[131, 1479, 472, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION,"[444, 68, 1056, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,1,number,855,"[1083, 68, 1118, 87]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,text,"calf serum). For experiments, chondrocytes were detached using trypsin, pooled into a single aliquot, counted, and then separated into culture wells using DMEM containing 0.1% calf serum. The use of 0","[106, 117, 601, 496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,paragraph_title,Cell Proliferation,"[108, 514, 252, 534]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell Proliferation""]",subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,False,True +2,4,text,"DNA content of cell layer was used as an index of cell number, and an increase in cell number was used as an indication of increased cell proliferation. The culture media was removed and the cell laye","[107, 535, 602, 685]",unknown_structural,0.8,"[""page-1 zone author_zone: DNA content of cell layer was used as an index of cell numbe""]",authors,0.8,body_zone,body_like,none,False,True +2,5,paragraph_title,Nitric Oxide Measurement,"[108, 706, 329, 727]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Nitric Oxide Measurement""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +2,6,text,Nitrite in culture media was measured as an index of nitric oxide levels using the Griess reaction. $ ^{12} $ An aliquot (250 $ \mu $L) of conditioned culture media was collected and measured for nit,"[107, 728, 600, 834]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,cGMP Measurement,"[108, 854, 278, 873]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: cGMP Measurement""]",subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,False,True +2,8,text,The level of cGMP in the cell layer was measured using cGMP Enzyme Immunoassay Kit from Sigma (#CG200-1kt). The culture media was removed and the cell layer rinsed with PBS at 4°C. The cell layer was ,"[107, 873, 601, 1002]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,paragraph_title,PEF Signal,"[108, 1023, 198, 1044]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: PEF Signal""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +2,10,text,"The PEF signal (MedRelief® model SE55, Healthonics Inc, Atlanta, GA) is characterized by a pulse-burst waveform with a primary signal of asymmetrical biphasic rectangular pulses, 210/30 $ \mu $s in e","[106, 1045, 601, 1318]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,paragraph_title,Application of PEF Signal to Cell Culture,"[109, 1342, 436, 1363]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Application of PEF Signal to Cell Culture""]",subsection_heading,0.6,body_zone,body_like,none,True,True +2,12,text,"The PEF signal was delivered by capacitive coupling to chondrocytes using a novel replacement for traditional salt bridges. $ ^{13} $ In this new system, niobium wire jumpers were used instead of salt","[107, 1362, 602, 1470]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,text,"is closely controllable. The resulting vivid, nonfading light +interference colors are used in jewelry, and jeweler’s niobium +is manufactured in standard colors. Importantly for this +application, the h","[625, 117, 1121, 325]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,text,Niobium wire is cut and bent to form bridges between culture wells and the PEF signal passes through these bridges capacitively. Multiple wells are joined together in series. The wire is formed to fit,"[625, 326, 1120, 493]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,text,Preliminary studies found no indication of cytotoxicity when the PEF signal was delivered to either osteoblasts or chondrocytes via the niobium bridge. No changes in temperature or pH were detected in,"[625, 494, 1121, 641]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,16,paragraph_title,Statistics,"[627, 660, 706, 680]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Statistics""]",sub_subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,True,True +2,17,text,For all measures the average value and standard deviation are reported. Number of samples per group was six. Data is expressed as percent of control values. Multiple control bars in a graph indicate c,"[624, 682, 1122, 1061]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: For all measures the average value and standard deviation ar""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,18,paragraph_title,RESULTS,"[628, 1081, 720, 1104]",section_heading,0.9,"[""explicit scholarly heading: RESULTS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,19,text,The experimental design was to first investigate whether PEF had an effect on chondrocyte DNA content measured 72 h after PEF treatment. The experimental design then focused on changes in second messe,"[625, 1105, 1120, 1292]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,20,paragraph_title,Effect of Stimuli on Chondrocytes after 72 Hours,"[627, 1309, 1043, 1331]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of Stimuli on Chondrocytes after 72 Hours""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,21,text,A single 30-min treatment period to PEF with an amplitude producing 2.7 microamperes across culture media and an electric field of 0.2 mV/cm significantly increased DNA content by $ 133 \pm 10\% $ (p,"[625, 1332, 1120, 1471]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,22,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[781, 1496, 1119, 1515]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,number,856,"[68, 68, 105, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,FITZSIMMONS ET AL.,"[135, 67, 316, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,chart,,"[80, 116, 546, 434]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,"Figure 1. Effect on DNA content after 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In the graph above, PEF signal was ","[66, 446, 559, 628]",figure_caption,0.92,"[""figure_title label: Figure 1. Effect on DNA content after 72 h. Normal human cho""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,"Insulin-like growth factor 1 and added calf serum (increases calf serum from 0.1 to 1.0%) also increased DNA content, as shown in Figure 1. A dose response to IGF1 showed higher concentrations (up to ","[66, 644, 558, 783]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Effect of PEF Treatment on Short-Term NO Release,"[67, 806, 500, 827]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of PEF Treatment on Short-Term NO Release""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,6,text,In preliminary studies it was found that PEF could increase NO content transiently within 30 min of initiation of PEF treatment and the elevated NO levels would typically return to control levels shor,"[65, 826, 559, 988]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"To determine pathways involved in response to PEF treatment, chondrocytes were PEF treated in experiments with and without inhibitors. As shown in Figure 2, PEF treatment increased NO levels when meas","[65, 988, 559, 1217]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,In another series of experiments adding either 0.5 mM $ CaCl_{2} $ to the culture media or the calcium ionophore A23187 to 1 mM and measuring NO content of culture media 30 min later showed an increa,"[65, 1218, 559, 1379]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"Effect of PEF Treatment on Short-Term cGMP Generation Nitric oxide acts as a second messenger for the activation of guanylate cyclase (15). Therefore, cGMP was","[66, 1401, 559, 1472]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,chart,,"[598, 114, 1063, 493]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,11,figure_title,Figure 2. PEF signal and short-term (30 min) NO release. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (lig,"[584, 503, 1079, 744]",figure_caption,0.92,"[""figure_title label: Figure 2. PEF signal and short-term (30 min) NO release. Nor""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,12,text,"measured in the cell layer after PEF treatment. As shown in Figure 3, PEF treatment increased cGMP within the 30-min treatment period. This effect was blocked by either W7 or by L-NAME, as expected if","[583, 772, 1081, 865]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,chart,,"[598, 887, 1063, 1262]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,14,figure_title,Figure 3. PEF signal increases short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf-serum and allowed to attach and equilibrate for 24 h. In one expe,"[584, 1274, 1079, 1470]",figure_caption,0.92,"[""figure_title label: Figure 3. PEF signal increases short-term (30 min) cGMP gene""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,15,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[68, 1498, 406, 1517]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,header,PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION,"[445, 67, 1056, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,857,"[1083, 68, 1118, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,chart,,"[122, 115, 585, 442]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,3,figure_title,Figure 4. PEF signal and SNP increase short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. The ,"[107, 455, 601, 650]",figure_caption,0.92,"[""figure_title label: Figure 4. PEF signal and SNP increase short-term (30 min) cG""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,4,text,cGMP was increased in a cascade from calmodulin to nitric oxide synthase to cGMP.,"[107, 713, 600, 758]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"In Figure 4, both PEF and a nitric oxide donor (SNP) increased cGMP content of the cell layer within 30 min of treatment. The guanylate cyclase inhibitor (LY83583) blocked both PEF treatment and SNP f","[107, 759, 601, 967]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Effect of Inhibitors on Ability of PEF Treatment to Increase DNA Content at 72 Hours,"[108, 991, 527, 1034]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of Inhibitors on Ability of PEF Treatment to Increase""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,7,text,"In Figure 5, PEF treatment, when applied one time for 30 min, increased chondrocyte proliferation as observed in previous experiments. When L-NAME was added prior to PEF treatment the increase in chon","[107, 1035, 600, 1195]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"Effect of SNP on Chondrocyte Proliferation at 72 Hours +In Figure 6, SNP was added to a final concentration of 150 $ \mu $M, which increased nitric oxide content in culture media to 752 ± 74% of contr","[106, 1217, 602, 1470]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,chart,,"[640, 117, 1106, 476]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,10,figure_title,Figure 5. PEF signal and increased DNA content at 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (ligh,"[627, 486, 1121, 687]",figure_caption,0.92,"[""figure_title label: Figure 5. PEF signal and increased DNA content at 72 h. Norm""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,11,text,"content when present for 30 min, which is similar to the profile of NO release with PEF alone.","[626, 713, 1120, 760]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,DISCUSSION,"[629, 781, 762, 803]",section_heading,0.9,"[""explicit scholarly heading: DISCUSSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,13,text,Normal tissue regeneration proceeds through a series of phases starting with inflammation $ ^{16} $ and culminating in the deposition and organization of new tissue. In the,"[626, 805, 1122, 875]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,chart,,"[639, 895, 1105, 1259]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,15,figure_title,Figure 6. SNP and PEF effects on DNA. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. Cultures were treated to SNP (an NO donor,"[625, 1274, 1120, 1469]",figure_caption,0.92,"[""figure_title label: Figure 6. SNP and PEF effects on DNA. Normal human chondrocy""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,16,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[782, 1497, 1119, 1515]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,number,858,"[69, 68, 104, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,FITZSIMMONS ET AL.,"[135, 68, 317, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,text,"case of chronic joint pain, whether due to a prior injury or osteoarthritis, tissue regeneration stalls indefinitely in the inflammation phase. This leads to progressive degeneration of cartilage, irr","[65, 117, 559, 255]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,text,"Cartilage degradation in itself does not translate as a sensory perception directly from the cartilage; joint pain is the symptom that causes patients to seek treatment. Unfortunately, treatments aime","[65, 256, 559, 622]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"This study utilized a PEF signal adapted from the signal used in bone growth stimulators, employed successfully for recalcitrant bone fractures. $ ^{17} $ There are a number of similarities between th","[66, 622, 558, 1034]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,The results of this study also suggest that release of NO is part of the biologic pathway involved in increased DNA content of chondrocyte cultures following PEF treatment. NO increased within the 30-,"[65, 1035, 559, 1287]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,6,text,"Nitric oxide has many influences, $ ^{16,21} $ of which one can be activation of guanylate cyclase, which produces cGMP. $ ^{15} $ This study showed that the PEF signal increased cGMP within the 30-mi","[65, 1286, 559, 1471]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,7,text,"cultures following PEF signal treatment was blocked by +LY83583, thereby indicating cGMP is involved in the +pathway of PEF-stimulated DNA content of chondrocyte +cultures. +I h i i i id l ld b","[583, 117, 1079, 209]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,text,"In these experiments nitric oxide release could be increased with added calcium or a calcium ionophore, which is consistent with reports that NOS can be regulated by calcium. $ ^{23} $ When the calmod","[583, 210, 1079, 415]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,9,text,"Taken together, the data indicates this PEF signal stimulates chondrocyte proliferation through a biological pathway that involves calcium/ calmodulin, nitric oxide synthase, nitric oxide, and cGMP. T","[583, 415, 1079, 759]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"Whether this PEF signal can impart beneficial action to cartilage in human patients, of course, remains to be tested. One limitation of this study is the use of chondrocytes in cell culture, and the o","[583, 759, 1080, 1013]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,paragraph_title,ACKNOWLEDGMENTS,"[587, 1037, 811, 1059]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +5,12,text,"This study was partially funded, and the PEF generators were supplied, by Healthonics Inc., Altanta, GA.","[584, 1061, 1077, 1105]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,paragraph_title,REFERENCES,"[588, 1124, 714, 1146]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +5,14,reference_content,"1. Felson D, Zhang Y. 1998. 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Biochemical and morphological study of human articular chondrocytes cultivated in the presence of pulsed signal therapy. Ann Rheum Dis 61:1032–103","[635, 182, 1118, 259]",reference_item,0.85,"[""reference content label: 19. Fioravanti A, Nerucci F, Collodel G, et al. 2002. Bioche""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,15,reference_content,"20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression of neuronal nitric oxide synthase and phospholipase C- $ \gamma $1 in regenerating murine neuronal cells by pulsed electromagnetic field. Exp","[633, 262, 1118, 338]",reference_item,0.85,"[""reference content label: 20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,16,reference_content,"21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric oxide and wound repair: role of cytokines. Nitric Oxide 7:1–10.","[632, 341, 1117, 379]",reference_item,0.85,"[""reference content label: 21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,17,reference_content,"22. Miura M, Takayama K, Okada J. 1993. Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation. J Physiol 461:513–524.","[633, 381, 1118, 439]",reference_item,0.85,"[""reference content label: 22. Miura M, Takayama K, Okada J. 1993. Increase in nitric o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,18,reference_content,"23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J B","[633, 442, 1119, 537]",reference_item,0.85,"[""reference content label: 23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxid""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,19,reference_content,"24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/ligand binding kinetics: prediction of bioeffective waveform parameters. Bioelectrochem Bioenerg 48:27–34.","[633, 541, 1118, 598]",reference_item,0.85,"[""reference content label: 24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,20,reference_content,"25. Markov MS, Pilla AA. 1997. Weak static magnetic field modulation of myosin phosphorylation in a cell-free preparation: calcium dependence. Bioelectrochem Bioenergetics 43:235–240.","[633, 601, 1118, 676]",reference_item,0.85,"[""reference content label: 25. Markov MS, Pilla AA. 1997. Weak static magnetic field mo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,21,reference_content,"26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transduction in electrically stimulated bone cells. J Bone Joint Surg 83-A:1514–1523.","[633, 681, 1118, 737]",reference_item,0.85,"[""reference content label: 26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transd""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,22,reference_content,"27. Ciombor DM, Lester G, Aaron RK, et al. 2002. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. J Orthop Res 20:40–50.","[632, 741, 1120, 798]",reference_item,0.85,"[""reference content label: 27. Ciombor DM, Lester G, Aaron RK, et al. 2002. Low frequen""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +6,23,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[781, 1497, 1118, 1515]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/2BYRLKQS/block_trace.csv b/tests/fixtures/ocr_real_papers/2BYRLKQS/block_trace.csv new file mode 100644 index 00000000..4f1ae376 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/2BYRLKQS/block_trace.csv @@ -0,0 +1,182 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107, 65, 676, 108]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,header_image,,"[732, 65, 1082, 135]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,text,RESEARCH ARTICLE,"[116, 181, 393, 211]",authors,0.6,"[""page-1 initial-lastname author byline: RESEARCH ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,3,text,Open Access,"[920, 184, 1073, 212]",frontmatter_noise,0.7,"[""frontmatter noise text: Open Access""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus),"[109, 242, 995, 396]",paper_title,0.8,"[""page-1 zone title_zone: Effects of microcurrent stimulation on Hyaline cartilage rep""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Carla de Campos Ciccone¹, Denise Cristina Zuzzi¹, Lia Mara Grosso Neves¹, Josué Sampaio Mendonça¹, Paulo Pinto Joazeiro² and Marcelo Augusto Marretto Esquisatto¹*","[107, 411, 980, 470]",authors,0.8,"[""page-1 zone author_zone: Carla de Campos Ciccone\u00b9, Denise Cristina Zuzzi\u00b9, Lia Mara G""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,paragraph_title,Abstract,"[122, 518, 208, 545]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True +1,7,abstract,"Background: In this study, we investigate the effects of microcurrent stimulation on the repair process of xiphoid cartilage in 45-days-old rats.","[118, 555, 1056, 606]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,8,abstract,"Methods: Twenty male rats were divided into a control group and a treated group. A 3-mm defect was then created with a punch in anesthetized animals. In the treated group, animals were submitted to da","[119, 610, 1065, 730]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,9,abstract,"Results: Basophilia increased gradually in control animals during the experimental period. In treated animals, newly formed cartilage was observed on days 21 and 35. No statistically significant diffe","[119, 735, 1067, 906]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,abstract,Conclusion: We conclude that microcurrent stimulation accelerates the cartilage repair in non-articular site from prepuberal animals.,"[120, 911, 1041, 960]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,11,text,"Keywords: Hyaline cartilage, Tissue repair, Extracellular matrix, Electrotherapy, Immature rats","[118, 968, 873, 995]",structured_insert,0.7,"[""keyword-like block: Keywords: Hyaline cartilage, Tissue repair, Extracellular ma""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,12,paragraph_title,Background,"[109, 1029, 228, 1052]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Background""]",section_heading,0.5,body_zone,heading_like,short_fragment,True,True +1,13,text,Most studies on cartilage repair use models of osteochondral defects since these defects are a major public health problem. Although these models permit to monitor the integration of articular cartila,"[106, 1054, 585, 1222]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,text,"Hyaline cartilage is a highly specialized, aneural and avascular connective tissue derived from the embryonic mesenchyme. Morphologically, this tissue is characterized by the presence of a small numbe","[107, 1223, 585, 1271]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,text,"mesenchyme. Morphologically, this tissue is character- +ized by the presence of a small number of cells, called +chondrocytes, which are responsible for the production, +organization and renewal of extra","[603, 1029, 1081, 1222]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,text,"The ECM is formed by a complex of macromolecules including collagens, proteoglycans (PGs) and non-collagen proteins. The interaction of these components ensures that an adequate amount of water is ret","[603, 1222, 1083, 1367]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,footnote,* Correspondence: marcelosquisatto@uniararas.br,"[109, 1314, 413, 1332]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: marcelosquisatto@uniararas.br""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,18,footnote,"Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil","[108, 1332, 570, 1390]",footnote,0.7,"[""footnote label: Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biom\u00e9dicas, Centro Uni""]",footnote,0.7,body_zone,body_like,none,True,True +1,19,footnote,Full list of author information is available at the end of the article,"[108, 1386, 513, 1405]",footnote,0.7,"[""footnote label: Full list of author information is available at the end of t""]",footnote,0.7,body_zone,body_like,none,True,True +1,20,footer_image,,"[110, 1421, 336, 1467]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +1,21,footer,© 2013 de Campos Ciccone et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/license,"[354, 1420, 1031, 1472]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108, 65, 676, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,1,number,Page 2 of 9,"[997, 64, 1082, 88]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,text,"Chondrocytes are nourished by the diffusion of nutrients through the ECM, either from synovial fluid or from capillaries in the perichondrium [5,6].","[106, 176, 585, 249]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"The cartilaginous ECM consists of fibrillar elements such as collagen and elastin and PGs. The main types of collagen found in cartilage are, in decreasing order, types II, IX and XI. Collagen fibrils","[106, 247, 587, 946]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,Non-articular cartilage differs from articular cartilage by the fact that it is does not suffer the wear and tear of weight-bearing articular cartilage and that the defects induced are chondral and no,"[106, 944, 586, 1281]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"There are various treatment options for articular cartilage defects. Electrical and electromagnetic stimulation and autologous grafts of chondrocytes, mesenchymal cells and biocompatible tissue derive","[106, 1280, 586, 1476]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"Within this context, electrical stimulation as a thera- +peutic strategy for cartilage repair has been little investi- +gated [6,25,26] and knowledge about the response of +cartilage tissue of different ","[602, 176, 1084, 441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"Therefore, the objective of the present study was to investigate the structural and ultrastructural alterations that occur during the healing of non-articular cartilage defects after microcurrent stim","[602, 441, 1082, 561]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,Methods Experimental groups,"[604, 582, 781, 632]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Methods Experimental groups""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,True,True +2,9,footer,,"[604, 609, 781, 632]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,10,text,"1wenty male Wistar rats, 45 days old and weighing 150 to 200 g, were obtained from the Center of Animal Experimentation, Centro Universitário Hermínio Ometto, UNIARARAS. The animals were housed in ind","[601, 631, 1083, 874]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: 1wenty male Wistar rats, 45 days old and weighing 150 to 200""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,11,paragraph_title,Experimental injury,"[604, 897, 772, 920]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Experimental injury""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +2,12,text,"The animals were anesthetized with xylazine hydrochloride (0.2 mg/kg) and ketamine hydrochloride (1 mg/kg). After the ventral region was shaved at the height of the sternum, a 2-cm incision was made i","[602, 920, 1082, 1379]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,paragraph_title,Electrical current stimulation,"[604, 1401, 845, 1423]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrical current stimulation""]",subsection_heading,0.6,body_zone,body_like,none,True,True +2,14,text,Animals of the treated group received daily applications of a biphasic square pulse microgalvanic continuous,"[602, 1423, 1083, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107, 65, 676, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,Page 3 of 9,"[997, 64, 1082, 88]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,"electrical current during 5 min (Physiotonus Microcurrent© stimulator - Bioset, Rio Claro, Sao Paulo, Brazil). In each application, it was used a frequency of 0.3 Hz and intensity of 20 μA. The pulse ","[106, 175, 586, 683]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,Macroscopic inspection,"[107, 704, 307, 727]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Macroscopic inspection""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,4,text,"Xiphoid cartilage specimens fixed for histochemical analysis were used. The specimens were photographed with a PinePIX 300 digital camera in the front view. Anatomical features, including the appearan","[105, 727, 586, 875]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Histochemistry analysis,"[107, 897, 306, 919]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histochemistry analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,6,text,"After removal, the xiphoid cartilage fragments were fixed in 10% formaldehyde in Millonig buffer, pH 7.4, for 24 h at room temperature. The specimens were then transferred to buffer and processed rout","[106, 920, 586, 1330]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,paragraph_title,Electron microscopy and cytochemistry study,"[107, 1353, 484, 1376]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electron microscopy and cytochemistry study""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,8,text,"The cartilage samples of the two groups were fixed in 2% glutaraldehyde and 0.1% tannic acid dissolved in 0.1 M sodium cacodylate buffer, pH 7.3, for 2 h at room temperature. Next, the material was wa","[106, 1376, 587, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"and postfixed in 1% osmium tetroxide for 1 h at 4°C. +After this step, the fragments were washed in glycated +saline, treated with 1% uranyl acetate for 18 at 4°C, again +washed in glycated saline, and d","[602, 175, 1084, 634]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,paragraph_title,Morphometric and statistical analysis,"[603, 656, 914, 680]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Morphometric and statistical analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,11,text,"The cartilage repair area was determined on the digitized images as percent reduction of the original defect. Images of longitudinal sections stained with Toluidine blue, Dominici stain and picrosiriu","[602, 681, 1083, 1163]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,paragraph_title,Results,"[604, 1182, 681, 1206]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,13,text,Macroscopic inspection of the wound area showed the circular shape of the defect in control and treated animals and the absence of hemorrhagic or infectious processes at any of the time points studied,"[601, 1208, 1082, 1377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,text,"Toluidine blue staining (Figure 1) revealed a larger number of connective tissue cells in treated animals on day 7 when compared to the control group. In addition, a higher concentration of connective","[601, 1376, 1083, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108, 65, 675, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,Page 4 of 9,"[997, 65, 1082, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,figure_title,Table 1 Morphometric parameters evaluated in the defect area after different periods of time,"[107, 176, 531, 220]",table_caption,0.9,"[""table prefix matched: Table 1 Morphometric parameters evaluated in the defect area""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,3,table,"
ParameterTimeControl groupTreated group
7d$ 2.5 \pm 1.1 $$ 2.9 \pm 1.8 $
Lesion r","[107, 217, 581, 751]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,4,vision_footnote,"Measurements were obtained from samples collected on day 7 (7d), day 21 (21d), and day 35 (35d) after experimental injury. Three samples per animal were collected from the central region of the defect","[107, 755, 567, 861]",footnote,0.7,"[""vision_footnote label: Measurements were obtained from samples collected on day 7 (""]",footnote,0.7,body_zone,body_like,none,True,True +4,5,text,in central islands was observed in treated animals on day 21. New tissue formation accompanied by intense basophilia at the defect margins was seen in treated animals on day 21 and especially on day 3,"[602, 175, 1083, 513]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,Analysis of sections stained with picrosirius-hematoxylin and examined by bright-field microscopy under polarized light (Figure 2) showed a predominance of thick collagen fibers in the control group a,"[601, 513, 1083, 872]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,Electron photomicrographs of the repair tissue treated by the tannic acid method are shown in Figure 3. Fibroblast-like cells were observed in control animals on days 7 and 21. These cells were surrou,"[602, 872, 1083, 971]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,image,,"[252, 1007, 937, 1373]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,9,figure_title,Figure 1 Photomicrographs of longitudinal sections of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 µA/5 min). Spe,"[115, 1377, 1068, 1462]",figure_caption,0.92,"[""figure_title label: Figure 1 Photomicrographs of longitudinal sections of the xi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107, 65, 675, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,Page 5 of 9,"[997, 64, 1082, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,image,,"[253, 187, 936, 911]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,Figure 2 Photomicrographs of sections stained with picrosirius-hematoxylin and analyzed by bright-field microscopy under polarized light (D-F and J-L). A-F: Control group; G-L: treated group. Specimen,"[116, 919, 1059, 984]",figure_caption,0.92,"[""figure_title label: Figure 2 Photomicrographs of sections stained with picrosiri""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,image,,"[251, 1039, 938, 1391]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,figure_title,Figure 3 Electron photomicrographs of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 μA/5 min). Specimens were coll,"[115, 1398, 1065, 1462]",figure_caption,0.92,"[""figure_title label: Figure 3 Electron photomicrographs of the xiphoid cartilage ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108, 65, 676, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,Page 6 of 9,"[997, 65, 1081, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,2,text,"pericellular matrix that was looser than that seen in the region of the territorial matrix. In contrast, chondroblast-like cells characterized by cytoplasm rich in secretory vesicles and abundant roug","[107, 176, 586, 633]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,3,text,Figure 4 shows electron photomicrographs of the repair tissue submitted to cytochemical staining of PGs. Larger PG complexes were observed in treated animals on day 7 when compared to the control grou,"[106, 632, 586, 898]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 4 shows electron photomicrographs of the repair tissu""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +6,4,paragraph_title,Discussion,"[108, 919, 216, 942]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +6,5,text,"Since non-articular cartilage defects and repair are uncommon in clinical practice, studies investigating these processes are important to gain insights into the reorganization of this tissue under di","[106, 944, 586, 995]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,text,"these processes are important to gain insights into the +reorganization of this tissue under different functional +conditions of the joints. In a recent study, Moyer et al. +[19] observed regeneration of","[602, 176, 1084, 560]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"In the present study, only a small amount of newly formed cartilage was observed at the defect margins in all treated animals after 35 days of uninterrupted microcurrent application. These findings ag","[601, 561, 1083, 872]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,"Another relevant finding was the effect of microcurrent stimulation on the total number of fibroblast cells, which was higher in all treated animals when compared to the respective control group. In a","[601, 872, 1083, 995]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,image,,"[250, 1033, 946, 1390]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,10,figure_title,"Figure 4 Electron photomicrographs of sections from control (A-C) and treated (D-F) animals stained with cuprolinic blue for the detection of proteoglycans (PG). Specimens were collected 7 (A and D), ","[118, 1398, 1023, 1462]",figure_caption,0.92,"[""figure_title label: Figure 4 Electron photomicrographs of sections from control ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107, 65, 676, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,Page 7 of 9,"[997, 65, 1081, 88]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,"organization of cartilage in treated animals may be the result of the beneficial effects of electrical stimulation on the production, maintenance and organization of ECM [6,31]. According to Aaron et ","[106, 176, 586, 369]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"Another factor related to the effects of microcurrent stimulation is the induction of the proliferative and differentiation capacity of mesenchymal cells, which are found mainly in young animals [6,32","[106, 369, 587, 729]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"The abundant presence of granulocytes in treated animals on days 7 and 21 is consistent with one of the most well-known effects of electrotherapy, particularly electrical current stimulation, i.e., th","[107, 729, 587, 1209]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,A larger number of birefringent fibers indicating a larger number of compacted collagen fibers were observed in control animals on day 35. The lack of an effect of electrical current stimulation on fi,"[106, 1208, 587, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"of the healing process by increasing collagen fiber depos- +ition, cell proliferation, growth factor concentration, and +ATP levels. In addition to these observations, Kirsch and +Mercola [40] suggest th","[602, 176, 1083, 417]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"Although the ideal parameters and type of electrical stimulation that is safe and efficient in promoting connective tissue repair, particularly cartilage repair $ [33,44] $, have not been established","[602, 416, 1083, 585]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"In contrast to collagen fibers, the number of elastic fibers seems to be little influenced by microcurrent treatment. Traces of these fibers were observed in the two groups and at the different time p","[602, 585, 1082, 776]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"Several studies on cartilage repair have shown that microcurrents tend to induce the formation of fibrocartilage in chondral defects, whereas osteochondral defects are filled with cartilage tissue sin","[601, 776, 1083, 1112]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,"The adequate combination of collagen fibrils and fibers and highly hydrated PGs permits cartilage to withstand the functional requirements during normal activity [4,47]. In the present study, no diffe","[602, 1112, 1084, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108, 66, 675, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,Page 8 of 9,"[998, 66, 1081, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,text,"other hand, the number of stained PGs seems to indicate a positive effect of treatment on the deposition of these molecules in the tissue.","[107, 177, 584, 247]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,The predominance of chondroblast-like cells in the defect area of treated animals since the beginning of treatment highlights another important aspect of the effect of microcurrent stimulation on the ,"[107, 248, 585, 514]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,Conclusion,"[109, 537, 217, 559]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +8,5,text,"We demonstrated that microcurrent stimulation has shown beneficial effects during non-articular cartilage repair in prepuberal animals. However, the period of observation was not sufficient to evaluat","[107, 562, 585, 729]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,paragraph_title,Competing interests,"[110, 747, 249, 764]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing interests""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,7,text,The authors declare that they have no competing interest.,"[109, 764, 470, 783]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,paragraph_title,Authors' contributions,"[109, 801, 263, 819]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Authors' contributions""]",subsection_heading,0.6,body_zone,body_like,none,True,True +8,9,text,"CCC, DCZ and LMGN carried out experimental work, data collection and evaluation, literature search and manuscript preparation. JSM helped the surgical procedure and data collection. PPJ helped to prep","[107, 819, 583, 929]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,paragraph_title,Acknowledgements,"[110, 948, 245, 964]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,11,text,"The authors thank the technicians of the Laboratory of Micromorphology, Centro Universitário Hermínio Ometto, UNIARARAS, and of the Laboratory of Electron Microscopy, Instituto de Biologia, Universida","[108, 965, 579, 1039]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,paragraph_title,Author details,"[110, 1055, 209, 1073]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author details""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,13,text,"¹Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil. ²Departamento de Histologia e ","[109, 1073, 568, 1165]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,14,text,Received: 2 August 2012 Accepted: 16 January 2013 Published: 19 January 2013,"[109, 1182, 447, 1218]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,paragraph_title,References,"[111, 1236, 188, 1254]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +8,16,reference_content,"1. Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW: Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. Eur Cell Mater 2008, 16(1):26–33.","[111, 1256, 562, 1308]",reference_item,0.85,"[""reference content label: 1. 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Lee BY, Wendell K, Al-Waili N, Butler G: Ultra-low microcurrent therapy: a novel approach for treatment of chronic resistant wounds. Adv Ther 2007, 24:1202–1209.","[112, 577, 582, 629]",reference_item,0.85,"[""reference content label: 39. Lee BY, Wendell K, Al-Waili N, Butler G: Ultra-low micro""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,12,reference_content,"40. Kirsch DL, Mercola JM: The basis for microcurrent electrical therapy in conventional medical practice. J Adv Med 1995, 8:83–97.","[112, 630, 561, 667]",reference_item,0.85,"[""reference content label: 40. Kirsch DL, Mercola JM: The basis for microcurrent electr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,13,reference_content,"41. Cheng N, Hoof HV, Bock E, Hoogmartens MJ, Mulier JC, Ducker FJ, Sansen WM, Loecker W: The effect of electric current on ATP generation, protein synthesis, membrane transport in rat skin. Clin Orth","[111, 668, 577, 737]",reference_item,0.85,"[""reference content label: 41. Cheng N, Hoof HV, Bock E, Hoogmartens MJ, Mulier JC, Duc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,14,reference_content,42. Nordenstrom B: Biologically Closed Electrical Circuits. Uppsala: Nordic Medical Publications; 1983.,"[111, 738, 578, 774]",reference_item,0.85,"[""reference content label: 42. Nordenstrom B: Biologically Closed Electrical Circuits. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,15,reference_content,"43. Chao P-H, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT: Chondrocyte translocation response to direct current electric fields. J Biomech Eng 2000, 122:261–267.","[110, 776, 554, 827]",reference_item,0.85,"[""reference content label: 43. Chao P-H, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT: Ch""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,16,reference_content,"44. Dodge GR, Bowen JR, Wug OHC, Tokmakova K, Simon BJ, Aroojis A, Potter K: Electrical stimulation of the growth plate: a potential approach to an epiphysiodesis. Bioelectromagnetics 2007, 28:463–470","[111, 829, 572, 882]",reference_item,0.85,"[""reference content label: 44. Dodge GR, Bowen JR, Wug OHC, Tokmakova K, Simon BJ, Aroo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,17,reference_content,"45. Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct current-induced repair of articular cartilage in rabbit osteochondral defects. J Orthop Res 1990, 8:266–275.","[111, 883, 571, 935]",reference_item,0.85,"[""reference content label: 45. Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,18,reference_content,"46. Black J: Electrical Stimulation of Hard and Soft Tissue in Animal Models. Clin Plast Surg 1985, 12:243–257.","[111, 937, 572, 972]",reference_item,0.85,"[""reference content label: 46. Black J: Electrical Stimulation of Hard and Soft Tissue ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,19,reference_content,"47. Reichenberger E, Olsen BR: Collagens as organizers of extracellular matrix during morphogenesis. Semin Cell Dev Biol 1996, 7:631–638.","[112, 973, 577, 1008]",reference_item,0.85,"[""reference content label: 47. Reichenberger E, Olsen BR: Collagens as organizers of ex""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,20,reference_content,"48. Takei N, Akai M: Effect of direct current stimulation on triradiate physeal cartilage. In vivo study in young rabbits. Arch Orthop Trauma Surg 1993, 112:159–162.","[113, 1010, 574, 1061]",reference_item,0.85,"[""reference content label: 48. Takei N, Akai M: Effect of direct current stimulation on""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,21,text,"doi:10.1186/1472-6882-13-17 +Cite this article as: de Campos Ciccone et al.: Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus). BMC Complementary","[118, 1084, 550, 1154]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,22,paragraph_title,Submit your next manuscript to BioMed Central and take full advantage of:,"[642, 1213, 1049, 1259]",structured_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Submit your next manuscript to BioMed Central and take full ""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,False,False +9,23,text,• Convenient online submission,"[641, 1280, 850, 1299]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False +9,24,text,• Thorough peer review,"[640, 1305, 801, 1324]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False +9,25,text,• No space constraints or color figure charges,"[640, 1330, 938, 1350]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False +9,26,text,• Immediate publication on acceptance,"[641, 1356, 897, 1374]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False +9,27,text,"• Inclusion in PubMed, CAS, Scopus and Google Scholar","[641, 1380, 1001, 1399]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False +9,28,text,• Research which is freely available for redistribution,"[641, 1404, 987, 1424]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False +9,29,footer,Submit your manuscript at www.biomedcentral.com/submit,"[642, 1449, 839, 1480]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +9,30,footer_image,,"[904, 1448, 1050, 1478]",structured_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,,unknown_like,empty,False,False diff --git a/tests/fixtures/ocr_real_papers/2E4EPHN2/block_trace.csv b/tests/fixtures/ocr_real_papers/2E4EPHN2/block_trace.csv new file mode 100644 index 00000000..31c9073d --- /dev/null +++ b/tests/fixtures/ocr_real_papers/2E4EPHN2/block_trace.csv @@ -0,0 +1,262 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[70, 101, 139, 167]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,1,header,antioxidants,"[146, 114, 352, 155]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,2,header_image,,"[1030, 109, 1119, 168]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,3,text,Article,"[65, 208, 131, 231]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,Microcurrent and Gold Nanoparticles Combined with Hyaluronic Acid Accelerates Wound Healing,"[65, 232, 959, 313]",paper_title,0.8,"[""page-1 zone title_zone: Microcurrent and Gold Nanoparticles Combined with Hyaluronic""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Carolini Mendes 1,2, Anand Thirupathi 1,*⊕, Rubya Pereira Zaccaron 2, Maria Eduardo Anastácio Borges Corrêa 2, João V. S. Bittencourt 2, Laura de Roch Casagrande 2, Anadhelly C. S. de Lima 2, Lara L. ","[64, 334, 1108, 437]",authors,0.8,"[""page-1 zone author_zone: Carolini Mendes 1,2, Anand Thirupathi 1,*\u2295, Rubya Pereira Za""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text," $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningbo 315211, China","[326, 478, 842, 501]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningb""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,7,text," $ ^{2} $ Laboratory of Experimental Phisiopatology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Cricúima 88806-000, Brazil","[326, 501, 1121, 543]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $ Laboratory of Experimental Phisiopatology, Program ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,8,text," $ ^{3} $ Graduate Program of Biomedical Science, Herminio Ometto Foundation, Araras 13607-339, Brazil","[327, 544, 1051, 566]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{3} $ Graduate Program of Biomedical Science, Herminio Om""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,9,image,,"[69, 733, 178, 770]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,10,text,"Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corrêa, M.E.A.B.; Bittencourt, J.V.S.; Casagrande, L.d.R.; de Lima, A.C.S.; de Oliveira, L.L.; de Andrade, T.A.M.; Gu, Y.; et al. Microcurrent and","[65, 778, 308, 1037]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corr\u00eaa""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,image,,"[69, 1313, 185, 1353]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,12,text,Academic Editor: Reinhart M. Speeckaert,"[67, 1052, 260, 1097]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic Editor: Reinhart M. Speeckaert""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,13,text,"Received: 16 September 2022 +Accepted: 7 November 2022 +Published: 15 November 2022","[67, 1114, 259, 1183]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 16 September 2022\nAccepted: 7 November 2022\nPublis""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,14,text,"Publisher's Note: MDPI stays neutral +with regard to jurisdictional claims in +published maps and institutional affiliations. +* Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.)","[66, 1197, 307, 1289]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Publisher's Note: MDPI stays neutral\nwith regard to jurisdic""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,15,text,* Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.),"[327, 567, 885, 589]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.n""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,16,text,"Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66, 1363, 309, 1551]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2022 by the authors. Licensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,17,abstract,Abstract: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. Fifty Wistar rats (n = 10,"[326, 614, 1125, 1105]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,18,text,Keywords: wound healing; iontophoresis; gold nanoparticles; hyaluronic acid; inflammation,"[327, 1133, 1072, 1158]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: wound healing; iontophoresis; gold nanoparticles; ""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,19,paragraph_title,1. Introduction,"[328, 1232, 473, 1255]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,20,text,"Currently, the prevalence of non-healing wounds in developed countries is 1 to 2%, and this rate is significantly increased in underdeveloped countries. However, this problem affects the population in","[325, 1263, 1125, 1462]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,21,text,"New materials and approaches are urgently desirable for wound healing since current treatments are closely restricted to bed hygiene and dressing changes; although essential, in some situations, these","[324, 1464, 1126, 1542]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,22,footer,"Antioxidants 2022, 11, 2257. https://doi.org/10.3390/antiox11112257","[66, 1625, 557, 1647]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,23,footer,https://www.mdpi.com/journal/antioxidants,"[784, 1625, 1122, 1648]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"Antioxidants 2022, 11, 2257","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,2 of 15,"[1068, 111, 1121, 131]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,2,text,"it is important to develop other approaches that accelerate the acute inflammatory and re-epithelialization process, thus avoiding complications and excessive expenditures in the health system [6,7].","[325, 192, 1123, 266]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"A microcurrent (MC) or a microgalvanic current is an electrical current in the range of microamperes ( $ \mu $A), polarized and continuous, and it promotes a physical stimulus and is non-invasive, non","[326, 268, 1125, 468]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Furthermore, through electrophoresis and electro-osmosis, MC allows the passage of charged and uncharged biomolecules across biological membranes. Iontophoresis is the collective name for these two pr","[326, 469, 1124, 669]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Currently, the development of nanomaterials, such as gold nanoparticles (GNPs), represents a promising approach to wound care [17]. Due to their focused delivery, lower toxicity, and higher absorption","[326, 670, 1124, 921]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"Hyaluronic acid (HA) is a component of the extracellular matrix, and it has excellent benefits for the treatment of dermal and epidermal lesions [22]. Its capacity to promote the production of fibrin,","[325, 920, 1124, 1274]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,2. Materials and Methods,"[328, 1291, 569, 1315]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,8,paragraph_title,2.1. Animals,"[328, 1318, 443, 1342]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Animals""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,text,"All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (Bethesda, MD, USA) and with t","[326, 1349, 1123, 1474]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,"Fifty Wistar male rats (60 days old, weighing between 250 and 300 g) were used, and they were kept at a controlled room temperature between $ 20 \pm 22\ ^{\circ}\mathrm{C} $, under a light-dark","[326, 1475, 1123, 1527]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"Antioxidants 2022, 11, 2257","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,3 of 15,"[1068, 111, 1121, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,2,text,"cycle 12/12 h, and with free access to water and food. Male rats were used so that there were no changes in the inflammatory analysis due to hormones.","[324, 192, 1122, 242]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,The animals were randomly assigned to five experimental groups with n = 10/group: excisional wound (EW) group—without local or systemic treatment; the EW + microcurrent treatment (EW + MC) group (300 ,"[326, 244, 1124, 369]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,paragraph_title,2.2. Excisional Wound Model,"[328, 387, 578, 410]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Excisional Wound Model""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,5,text,"The wound model was made using a circular excision as described by Mendes [21]. The animals were anesthetized with 4% isoflurane. The dorsal region of each animal was shaved, cleaned, and disinfected ","[325, 417, 1125, 546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,2.3. Treatment,"[328, 564, 455, 588]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Treatment""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,7,text,"The animals received microcurrent treatment using a Ibramed Striat Esthetic $ ^{\circledR} $ (Ibramed, São Paulo, Brazil) device with the function of a microgalvanic ( $ \mu $A) current lasting 20 min","[326, 594, 1125, 720]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"The first treatment session started 24 h after the injury, and the others were performed daily until the seventh day. The area treated with iontophoresis was the dorsal region, which was submitted to ","[326, 720, 1124, 848]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,2.4. Euthanasia,"[328, 865, 465, 890]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Euthanasia""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,10,text,"The animals were euthanized 12 h after the last application of the MC, HA, and/or GNPs. After that, the external border of the wound was surgically removed and immediately processed and stored in a fr","[326, 897, 1124, 974]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,2.5. Synthesis and Characterization of the GNPs,"[328, 992, 728, 1017]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Synthesis and Characterization of the GNPs""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,12,text,"Next, 20 nm GNPs were synthesized using the Turkevish method adapted by Della Vechia et al. [25]. The GNP solution was characterized using ultraviolet–visible (UV–VIS) spectroscopy with a spectrophoto","[325, 1023, 1124, 1199]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,paragraph_title,2.6. Wound Size Analysis,"[328, 1217, 546, 1242]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Wound Size Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,14,text,"Digital images of the wounds were taken at a resolution of $ 3264 \times 2448 $ pixels and analyzed using ImageJ $ ^{\textregistered} $ 1.51 software (National Institute of Mental Health, Bethesda, M","[326, 1249, 1124, 1400]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,paragraph_title,2.7. Histomorphometry,"[328, 1420, 526, 1445]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Histomorphometry""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,16,text,"The wound samples of four animals per group were conditioned for 48 h in a 10% formaldehyde-buffered solution (pH 7.4 phosphate buffer), followed by histological processing, and they were then embedde","[326, 1450, 1124, 1553]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"Antioxidants 2022, 11, 2257","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,4 of 15,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,2,text,"inflammatory infiltrate, blood vessels, and fibroblasts. Moreover, Ponceau S staining was performed to quantify the percentage area of total collagen compaction [29–32].","[325, 192, 1122, 242]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"Furthermore, all histological sections were visualized using a LEICA $ ^{\circledR} $ DM-2000B optical microscope with a LEICA $ ^{\circledR} $ DFC-300 FX (Leica Microsystems, Wetzlar, Germany) camera","[326, 242, 1123, 341]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,text,"For a simultaneous quantification (evaluated by a trained pathologist) of the inflammatory infiltrate and fibroblasts, the “Cell Counter” plugin in ImageJ software (5 images/animal/time/treatment in 4","[326, 343, 1126, 520]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,paragraph_title,2.8. Determination of Cytokine Content Using ELISA,"[328, 537, 774, 562]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Determination of Cytokine Content Using ELISA""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,6,text,"The samples were processed, and then the plate was sensitized for further incubation with the antibody. To measure cytokines (IFN $ \gamma $, TNF- $ \alpha $, IL-1 $ \beta $, IL-6, IL-4, IL-10, TGF- $","[326, 569, 1124, 671]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,paragraph_title,2.9. Biochemical Analysis,"[328, 688, 545, 713]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Biochemical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,8,text,"Tissue determination of Reactive Oxygen Species (ROS) and nitric oxide: The production of hydroperoxides was determined by the intracellular formation of 2',7' dichlorofluorescein (DCF) by ROS as desc","[326, 720, 1124, 820]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,Tissue determination of oxidative damage marker levels: The oxidative damage to protein in the homogenized skin tissue samples was measured by the determination of carbonyl groups. The total thiol con,"[326, 822, 1124, 920]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,"Tissue determination of antioxidant defenses: SOD was measured in homogenized skin tissue by the inhibition of adrenaline oxidation, which was adapted from Bannister and Calabrese [35]. A standard cur","[326, 921, 1123, 1020]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,Protein Content: The protein content in homogenized skin tissue was measured following the protocol from Corrêa et al. [34].,"[327, 1021, 1121, 1072]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,2.10. Statistical Analysis,"[328, 1091, 540, 1115]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,13,text,"Data are expressed as the mean ± standard error, and they were analyzed statistically using one-way analysis of variance (ANOVA) tests, followed by Tukey's post hoc tests. The significance level for t","[326, 1122, 1123, 1225]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,paragraph_title,3. Results,"[328, 1244, 426, 1266]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,15,paragraph_title,3.1. Physicochemical Properties of the GNP Solution,"[328, 1269, 760, 1295]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Physicochemical Properties of the GNP Solution""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,16,text,"To evaluate the formation and physical–chemical properties of the GNPs, UV–VIS, DLS, and zeta potential analyses were performed. The GNPs presented a maximum absorption peak at 524 nm and a ruby red c","[326, 1301, 1124, 1501]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,"Antioxidants 2022, 11, 2257","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,5 of 15,"[1069, 111, 1121, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,2,chart,,"[334, 191, 1100, 572]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,Figure 1. UV–VIS spectroscopy (A) and TEM images (B) of the GNP solution were obtained.,"[327, 590, 1065, 614]",figure_caption,0.92,"[""figure_title label: Figure 1. UV\u2013VIS spectroscopy (A) and TEM images (B) of the ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,paragraph_title,3.2. Analysis of the Wound Contraction Rate,"[328, 629, 703, 654]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Analysis of the Wound Contraction Rate""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,5,text,"We evaluated the wound contraction rate in %, represented by the reduction in the surface area (Figure 2), where all treated groups showed a significant difference compared to the control group.","[326, 660, 1122, 737]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,chart,,"[186, 756, 1015, 1034]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,7,figure_title,"Figure 2. Effects of treatment with MC, GNPs, and hyaluronic acid on wound contraction. The data are presented in mean ± EPM, in which **p < 0.01 vs. excisional wound group (EW) and ***p < 0.001 vs. e","[326, 1056, 1121, 1133]",figure_caption,0.92,"[""figure_title label: Figure 2. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,8,paragraph_title,3.3. Histological Analysis,"[328, 1148, 546, 1172]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Histological Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,9,text,"In Figures 3 and 4, representative images of the histological sections of the integumentary system can be seen. A decrease in the mean number of inflammatory infiltrates was found in the EW + MC group","[326, 1180, 1124, 1303]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"Despite analyzing the percentage of collagen area (Figure 4B), no significant difference was observed between the groups.","[326, 1304, 1123, 1354]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,0,header,"Antioxidants 2022, 11, 2257","[66, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,6 of 15,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,2,figure_title,A),"[334, 189, 365, 221]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,3,image,,"[368, 200, 1078, 365]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,4,vision_footnote,"■ Excisional Wound (EW) +■ EW + MC +■ EW + MC + HA +■ EW + MC + GNPs +■ EW + MC + HA + GNPs","[569, 383, 885, 545]",footnote,0.7,"[""vision_footnote label: \u25a0 Excisional Wound (EW)\n\u25a0 EW + MC\n\u25a0 EW + MC + HA\n\u25a0 EW + MC +""]",footnote,0.7,body_zone,unknown_like,none,True,True +6,5,figure_title,B),"[333, 546, 364, 577]",figure_inner_text,0.9,"[""panel label / figure inner text: B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,6,figure_title,C),"[705, 547, 735, 577]",figure_inner_text,0.9,"[""panel label / figure inner text: C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,7,chart,,"[337, 550, 701, 799]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,chart,,"[717, 552, 1055, 797]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,figure_title,"Figure 3. (A) Representative images of the histological sections of the integumentary system. (B,C) Effects of treatment with MC, GNPs, and hyaluronic acid on the number of inflammatory infiltrates (B","[326, 813, 1125, 917]",figure_caption,0.92,"[""figure_title label: Figure 3. (A) Representative images of the histological sect""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,10,figure_title,A),"[332, 930, 363, 958]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,11,image,,"[353, 939, 1098, 1110]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,12,figure_title,B),"[333, 1122, 365, 1154]",figure_inner_text,0.9,"[""panel label / figure inner text: B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,13,chart,,"[338, 1125, 1107, 1422]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,14,figure_title,"Figure 4. (A) Representative images of the histological sections of the integumentary system. (B) Effects of treatment with MC, GNPs, and hyaluronic acid on the % of collagen area. The data are presen","[326, 1439, 1125, 1515]",figure_caption,0.92,"[""figure_title label: Figure 4. (A) Representative images of the histological sect""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,0,header,"Antioxidants 2022, 11, 2257","[66, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,7 of 15,"[1068, 110, 1121, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,2,paragraph_title,3.4. Evaluation of Pro-Inflammatory Cytokines,"[327, 192, 717, 217]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Evaluation of Pro-Inflammatory Cytokines""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,3,text,"Figure 5 shows the protein levels of pro-inflammatory cytokines. In Figure 5A, INFγ levels decreased in the EW + MC + HA group (p < 0.05) and in the combined therapy group (p < 0.01) when compared to ","[325, 224, 1126, 400]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 5 shows the protein levels of pro-inflammatory cytoki""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +7,4,figure_title,A,"[334, 417, 356, 439]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,5,chart,,"[339, 418, 666, 627]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,6,figure_title,B,"[677, 417, 696, 438]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,7,chart,,"[680, 422, 1013, 625]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,8,chart,,"[601, 638, 810, 755]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,9,figure_title,C,"[333, 766, 353, 787]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,10,figure_title,D,"[676, 766, 697, 787]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,11,chart,,"[339, 782, 663, 983]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,12,chart,,"[693, 784, 1011, 982]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,"Figure 5. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of pro-inflammatory cytokines: (A) INF-Y, (B) TNF-α, (C) IL1-β, (D) IL6. The data are presented in mean ± EPM, i","[325, 995, 1124, 1123]",figure_caption,0.92,"[""figure_title label: Figure 5. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,14,paragraph_title,3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Factors,"[327, 1138, 892, 1163]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Fa""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,15,text,The protein levels of anti-inflammatory cytokines are shown in Figure 6. The levels of IL-4 (Figure 6A) and IL10 (Figure 6B) were increased in the EW + MC + HA and EW + MC + HA + GNPs groups in relati,"[326, 1171, 1124, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,16,text,The group treated with only the microcurrent (EW + MC) and the group in which the therapies were combined (EW + MC + HA + GNPs) showed a significant increase in the levels of TGF- $ \beta $ (Figure 6C,"[326, 1245, 1124, 1370]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,17,paragraph_title,3.6. Intracellular Determination of Oxidants,"[328, 1389, 699, 1414]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.6. Intracellular Determination of Oxidants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,18,text,It can be seen that only the group treated with the combined therapies (EW + MC + HA + GNPs) had their oxidant levels of DCFH (Figure 7A) and nitrite (Figure 7B) decreased when compared to the control,"[326, 1419, 1124, 1497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"Antioxidants 2022, 11, 2257","[66, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 15,"[1068, 111, 1121, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,figure_title,A,"[335, 191, 357, 215]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,3,chart,,"[338, 194, 659, 399]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,4,figure_title,B,"[677, 191, 697, 214]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,5,chart,,"[682, 202, 1004, 398]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,6,chart,,"[591, 410, 801, 529]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,7,figure_title,C,"[332, 536, 353, 558]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,8,chart,,"[337, 546, 660, 744]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,D,"[677, 537, 698, 558]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,10,chart,,"[682, 550, 1003, 743]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,11,figure_title,"Figure 6. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of anti-inflammatory cytokines: (A) IL4; (B) IL10; (C) TGF- $ \beta $; (D) FGF. The data are presented in mean ","[326, 755, 1125, 859]",figure_caption,0.92,"[""figure_title label: Figure 6. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,12,figure_title,A,"[333, 876, 356, 902]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,13,chart,,"[335, 888, 768, 1146]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,14,chart,,"[789, 941, 1016, 1220]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,15,figure_title,B,"[333, 1167, 355, 1191]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,16,chart,,"[354, 1179, 763, 1430]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,17,figure_title,"Figure 7. Effects of treatment with MC, GNPs, and hyaluronic acid on the levels of oxidants: (A) DCF; (B) nitrate. The data are presented in mean ± EPM, in which *p < 0.05 vs. excisional wound group (","[326, 1444, 1124, 1521]",figure_caption,0.92,"[""figure_title label: Figure 7. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,0,header,"Antioxidants 2022, 11, 2257","[66, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,number,9 of 15,"[1068, 110, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,paragraph_title,3.7. Markers of Oxidative Damage and Antioxidants,"[327, 191, 764, 217]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.7. Markers of Oxidative Damage and Antioxidants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +9,3,text,"Carbonyl levels had a significant decrease in the EW + MC + HA + GNI's group compared to the EW group (Figure 8A). When the sulfhydryl content was evaluated (Figure 8B), we observed that the EW + MC +","[325, 223, 1124, 351]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,figure_title,A,"[333, 373, 357, 398]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,5,chart,,"[337, 381, 697, 606]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,figure_title,B,"[724, 373, 747, 396]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,7,chart,,"[728, 385, 1097, 605]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,8,chart,,"[622, 623, 857, 749]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,9,figure_title,C,"[345, 766, 367, 791]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,10,chart,,"[347, 769, 699, 992]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,11,figure_title,D,"[720, 766, 743, 790]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,12,chart,,"[725, 773, 1098, 991]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,13,figure_title,"Figure 8. Effects of treatment with MIC, GNPs, and hyaluronic acid on the levels of oxidative damage markers and antioxidants: (A) carbonyl; (B) sulfhydryl; (C) SOD; (D) GSH. The data are presented in","[326, 1005, 1123, 1134]",figure_caption,0.92,"[""figure_title label: Figure 8. Effects of treatment with MIC, GNPs, and hyaluroni""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,14,text,Antioxidant defense was measured through reduced glutathione and superoxide dismutase levels. SOD levels (Figure 8C) showed a significant decrease in the combined therapy group (EW + MC + HA + GNPs). ,"[324, 1152, 1123, 1255]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,15,paragraph_title,4. Discussion,"[328, 1273, 458, 1296]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +9,16,text,"Wounds are a big problem in terms of social impact, and despite the wide range of therapies that can promote the repair of epithelial lesions, the incidence of wounds is progressively increasing, sinc","[324, 1304, 1123, 1505]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,17,text,"Clinical studies have reported positive wound healing results using electrical stimulation, and for a while, it has been utilized in clinical practice to speed up wound heal-","[326, 1506, 1127, 1556]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"Antioxidants 2022, 11, 2257","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,10 of 15,"[1062, 111, 1121, 132]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,text,"ing [37,38]. An MC is a specific type of microampere ( $ \mu $A) electrical stimulation that replicates currents generated in the body at the cellular level, and it is known to boost cell physiology a","[324, 192, 1125, 443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,text,"In line with what has been exposed, in the present study, a reduction in the levels of pro-inflammatory cytokines (IFN $ \gamma $, TNF $ \alpha $, IL-1 $ \beta $, and IL6) and inflammatory infiltrates","[325, 444, 1124, 568]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,"Individually, each therapy promotes some mechanisms of action in the tissue, and, when combined, they can potentiate their isolated effects. MCs allow the transport of bioactive molecules when combine","[325, 569, 1126, 870]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"Likewise, the use of GNPs can act as an anti-inflammatory agent in the treatment of various models of tissue injury [49] by blocking the activation of nuclear factor kappa β (NF-κB) and combining with","[323, 870, 1124, 1196]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"Only in the group receiving combination treatment was it possible to see an increase in anti-inflammatory cytokines and growth factors, together with a decline in pro-inflammatory cytokines. According","[325, 1197, 1126, 1550]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,0,header,"Antioxidants 2022, 11, 2257","[67, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,1,header,11 of 15,"[1062, 111, 1121, 132]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,text,"The effects attributed to HA describe the modulation of pathways that include the suppression of pro-inflammatory cytokines and chemokines [57], in addition to improving membrane stability and favorin","[325, 192, 1124, 443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,3,text,"By reducing the formation of reactive oxygen and nitrogen species, reducing oxidative damage, and stimulating the antioxidant system, the group that was subjected to the combination of the suggested t","[325, 444, 1125, 644]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"The capacity of HA to bind to the CD44 receptor, activate pathways involved in the control of cellular redox status, produce intracellular ROS, and chelate $ Fe^{2+} $ and $ Cu^{2+} $ ions—which are","[326, 644, 1124, 795]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,5,text,"Likewise, as an antioxidant agent, GNPs exhibit high catalytic activity for free radical scavenging reactions, affecting the thiol bonds of keap1, causing a conformational change that allows the relea","[325, 795, 1124, 970]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,6,text,"Since excessive levels of ROS in a wound pose a barrier to the healing process, our results show the potential of combined treatments (MC + HA + GNPs) to restore tissue redox homeostasis and to create","[326, 971, 1123, 1045]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,7,text,"Our findings demonstrate that the groups who received MC in conjunction with the topical application of compounds had a reduction in the inflammatory infiltrate when compared to the lesion group, whic","[325, 1046, 1124, 1246]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,8,text,"In line with that previously discussed, when evaluating the wound contraction rate in %, this study shows that all therapeutic approaches can promote the healing process by causing the wound to shrink","[326, 1247, 1124, 1422]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,9,text,"Taken together, these results are in agreement with those found in the study conducted by Mendes et al. (2020), where the benefits of using HA in combination with GNPs were also demonstrated and where","[325, 1422, 1125, 1525]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,0,header,"Antioxidants 2022, 11, 2257","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,number,12 of 15,"[1062, 111, 1121, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,paragraph_title,5. Conclusions,"[328, 192, 471, 216]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,3,text,"The proposed therapies, when combined, seem to enhance their mechanisms of action, with promising effects in the control of the acute inflammatory response, accelerating the transition to the prolifer","[325, 224, 1123, 298]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,"As a proposal for further studies, it is believed that, with longer analysis periods (between 14 and 21 days), the response of the combined therapy group (EW + MC + HA + GNPs) would have greater reper","[325, 299, 1124, 377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"Author Contributions: C.M.—Conceptualization, Data acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing—original draft, Writing—r","[325, 398, 1125, 633]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,support_like,none,True,True +12,6,text,"Funding: This research was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant number [Call CNPq 06/2019—Research Productivity Scholarships], Fundação de Amparo à Pesq","[326, 643, 1125, 762]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,text,Institutional Review Board Statement: The animal study protocol was approved by the University Ethics Committee (Universidade do Extremo Sul Catarinense—UNESC) with protocol number 16/2020.,"[325, 772, 1124, 820]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,8,text,Informed Consent Statement: Not applicable.,"[328, 832, 704, 854]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,Data Availability Statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.,"[327, 867, 1122, 914]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,10,text,Conflicts of Interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.,"[326, 926, 1122, 973]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +12,11,paragraph_title,References,"[67, 992, 175, 1015]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +12,12,reference_content,"1. Martinengo, L.; Olsson, M.; Bajpai, R.; Soljak, M.; Upton, Z.; Schmidtchen, A.; Car, J.; Järbrink, K. Prevalence of chronic wounds in the general population: Systematic review and meta-analysis of ","[65, 1022, 1122, 1089]",reference_item,0.85,"[""reference content label: 1. 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Electrically stimulated cell ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/tests/fixtures/ocr_real_papers/2GN9LMCW/block_trace.csv b/tests/fixtures/ocr_real_papers/2GN9LMCW/block_trace.csv new file mode 100644 index 00000000..699e5f61 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/2GN9LMCW/block_trace.csv @@ -0,0 +1,197 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[67, 127, 262, 313]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,doc_title,In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells,"[362, 124, 1123, 264]",paper_title,0.8,"[""page-1 zone title_zone: In vitro effect of direct current electrical stimulation on ""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,2,text,"Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishnu Thottakkattumana Parameswaran $ ^{1} $ and John Howard Barker $ ^{1} $","[361, 293, 1159, 350]",authors,0.8,"[""page-1 zone author_zone: Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishn""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text," $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Experimental Orthopedics and Trauma Surgery, Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany","[355, 361, 1119, 404]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Exp""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,4,text," $ ^{2} $School of Materials, Faculty of Engineering and Physical Sciences, University of Manchester, Manchester, United Kingdom","[355, 406, 1126, 447]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $School of Materials, Faculty of Engineering and Phys""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,5,text,These authors contributed equally to this work.,"[357, 449, 712, 472]",frontmatter_support,0.78,"[""first-surviving-page support text: These authors contributed equally to this work.""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True +1,6,paragraph_title,ABSTRACT,"[388, 510, 548, 539]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True +1,7,text,"Submitted 12 July 2016 +Accepted 22 November 2016 +Published 12 January 2017","[65, 948, 295, 1014]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Submitted 12 July 2016\nAccepted 22 November 2016\nPublished 1""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,8,abstract,"Background. Electrical stimulation (ES) has been successfully used to treat bone defects clinically. Recently, both cellular and molecular approaches have demonstrated that ES can change cell behavior","[383, 555, 1148, 1036]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,9,text,cc Copyright 2017 Mobini et al.,"[67, 1284, 202, 1333]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: cc Copyright 2017 Mobini et al.""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,10,text,OPEN ACCESS,"[70, 1408, 209, 1432]",frontmatter_noise,0.7,"[""frontmatter noise text: OPEN ACCESS""]",frontmatter_noise,0.7,body_zone,body_like,short_fragment,False,False +1,11,text,"Distributed under +Creative Commons CC-BY 4.0","[64, 1346, 316, 1391]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Distributed under\nCreative Commons CC-BY 4.0""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,12,text,Additional Information and Declarations can be found on page 10,"[65, 1172, 306, 1238]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Additional Information and Declarations can be found on page""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,13,text,"Corresponding author +Sahba Mobini, +sahba.mobini@manchester.ac.uk, +sahba.mobini@gmail.com","[64, 1023, 315, 1111]",frontmatter_support,0.78,"[""first-surviving-page support text: Corresponding author\nSahba Mobini,\nsahba.mobini@manchester.a""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True +1,14,text,DOI 10.7717/peerj.2821,"[66, 1247, 249, 1271]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,15,text,"Academic editor +Jalees Rehman","[65, 1120, 203, 1165]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic editor\nJalees Rehman""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,16,text,"Subjects Bioengineering, Cell Biology, Orthopedics","[362, 1087, 788, 1112]",frontmatter_noise,0.7,"[""keyword-like block: Subjects Bioengineering, Cell Biology, Orthopedics""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,17,text,"Keywords Direct current electrical stimulation, Bone marrow-derived mesenchymal stem cells, Adipose tissue-derived mesenchymal stem cells, Bone tissue engineering","[361, 1114, 1136, 1166]",frontmatter_noise,0.7,"[""keyword-like block: Keywords Direct current electrical stimulation, Bone marrow-""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,18,paragraph_title,INTRODUCTION,"[363, 1201, 585, 1231]",section_heading,0.9,"[""explicit scholarly heading: INTRODUCTION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,19,text,"Large segment bone defects, caused by open fractures, non-unions, infections and tumor resection are a major challenge in trauma and orthopedic surgery. Complications associated with current treatment","[361, 1245, 1159, 1423]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,footer,"How to cite this article Mobini et al. (2017), In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells. PeerJ 5:e2821; DOI 10.7717/peerj.2821","[362, 1497, 1143, 1534]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,PeerJ,"[61, 71, 156, 107]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,text,"hold great potential for achieving optimal bone healing while eliminating the associated drawbacks of conventional treatments (Petite et al., 2000).","[361, 167, 1149, 223]",unknown_structural,0.8,"[""page-1 zone author_zone: hold great potential for achieving optimal bone healing whil""]",authors,0.8,body_zone,body_like,none,False,True +2,2,text,Mesenchymal stem cells (MSCs) have been shown to be an attractive cell source for clinical bone tissue engineering applications. MSCs possess a great capacity for self-renewal and multi-lineage differ,"[361, 226, 1162, 758]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Electrical stimulation (ES) has been shown to be effective in nerve and cardiac tissue engineering applications, primarily due to the electric nature of these tissues (Ghasemi-Mobarakeh et al., 2011; ","[362, 760, 1159, 1379]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Recently, various different types of physical stimuli such as static magnetic fields, cyclic strain, low frequency vibration, and electric signals have been used to improve","[362, 1382, 1133, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63, 1501, 496, 1524]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_pattern,False,False +2,6,number,2/15,"[1117, 1503, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,PeerJ,"[61, 71, 156, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +3,1,text,"both the proliferative and the differentiation potential of stem cells. Specifically, ES has been shown to influence cell proliferation and differentiation in tissue engineering applications (Balint, ","[361, 167, 1163, 670]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,2,text,In the present study we exposed rat BM-MSCs and AT-MSCs to DC ES and compared osteogenic differentiation behavior in both cell types.,"[363, 673, 1156, 730]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,MATERIALS AND METHODS Groups,"[363, 756, 748, 824]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: MATERIALS AND METHODS Groups""]",section_heading,0.6,body_zone,heading_like,none,True,True +3,4,footer,,"[364, 796, 459, 824]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +3,5,text,"We designed our experiments to compare electrically stimulated (ES) versus not stimulated (Control) cell groups. Each group included both BM- and AT-derived rat MSCs, cultivated in osteogenic differen","[362, 827, 1161, 977]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,Cell preparation and culture,"[364, 991, 692, 1020]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell preparation and culture""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,7,text,"Sprague-Dawley (SD) rat MSC from bone marrow (RASMX-01001) and adipose tissue (RASMD-01001) were both obtained from Cyagen (CA, USA). Frozen vials of cells were thawed, cultured, and expanded to reach","[362, 1024, 1160, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63, 1501, 496, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +3,9,number,3/15,"[1116, 1502, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,PeerJ,"[61, 71, 156, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +4,1,image,,"[364, 176, 1154, 564]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,2,figure_title,"Figure 1 Setup for delivering direct current electrical stimulation to the cells. L-shaped platinum electrodes, 22 mm apart, secured to the lid of a 6-well cell culture plate and connected to a standa","[373, 585, 1147, 675]",figure_caption,0.92,"[""figure_title label: Figure 1 Setup for delivering direct current electrical stim""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,3,paragraph_title,Electrical stimulation of cells,"[363, 702, 703, 728]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrical stimulation of cells""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,4,text,"Electrical stimulation was applied by means of a purpose built DC ES cell culture chamber (Mobini, Leppik & Barker, 2016). Briefly, the chamber consists of L-shaped platinum electrodes, separated by a","[360, 733, 1161, 1033]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,paragraph_title,Cell viability and activity,"[363, 1048, 652, 1076]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,6,text,"To confirm that the oxidation–reduction and electrochemical reactions of the metallic electrodes in the DC ES chamber were not cytotoxic, cell viability and metabolic activity were assessed by 3-(4,5-","[360, 1081, 1161, 1379]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64, 1501, 496, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +4,8,number,4/15,"[1117, 1502, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,PeerJ,"[61, 71, 156, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +5,1,paragraph_title,Osteogenic differentiation,"[362, 165, 669, 192]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Osteogenic differentiation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,2,text,"Alizarin Red stains calcium deposits in the cells, indicating the presence of functional osteocytes. Cultured cells were washed twice with PBS and fixed with 4% paraformaldehyde (Sigma Aldrich, Münche","[361, 197, 1161, 403]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,text,"Transcription quantitative Polymerase Chain Reaction (RT-qPCR) technique. In brief, total RNA was isolated using an Aurum RNA isolation kit (BioRad, München, Germany) according to the manufacturer's i","[360, 417, 1159, 1151]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,paragraph_title,Data analysis,"[364, 1169, 525, 1196]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data analysis""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +5,5,text,"All experiments were performed in triplicate and statistical significance of differences between groups was analyzed by one-way ANOVA and student t-test using GraphPad Prism (GraphPad Software Inc, La","[362, 1200, 1158, 1410]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63, 1501, 496, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +5,7,number,5/15,"[1117, 1502, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,PeerJ,"[61, 71, 156, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +6,1,image,,"[366, 170, 1153, 859]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +6,2,figure_title,Figure 2 Calcium deposition. Calcium deposition stained using Alizarin Red S for; (A) BM-MSCs and AT-MSCs exposed to no electrical stimulation (controls) at days 7 and 14; (B) BM-MSCs and AT-MSCs expo,"[373, 882, 1149, 1019]",figure_caption,0.92,"[""figure_title label: Figure 2 Calcium deposition. Calcium deposition stained usin""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,3,text,in growth medium at day 0). Standard deviation (SD) was calculated with the $ \Delta C_{q} $ value of technical triplicates.,"[362, 1049, 1154, 1107]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,paragraph_title,RESULTS Electrical stimulation optimization,"[363, 1135, 760, 1204]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: RESULTS Electrical stimulation optimization""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +6,5,footer,,"[363, 1175, 760, 1204]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +6,6,text,"In order to optimize the electrical stimulation regime, first we exposed cells in culture to 10, 50, 100, and 200 mV/mm of DC ES for 1 h and found that 200 mV/mm caused cell lysis due to electro-chemi","[362, 1208, 1158, 1387]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64, 1501, 495, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +6,8,number,6/15,"[1117, 1502, 1158, 1523]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,PeerJ,"[61, 70, 156, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +7,1,chart,,"[372, 171, 1043, 729]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,2,figure_title,"Figure 3 Cell viability. Measured by MTT assay, compared between electrically stimulated and non-stimulated controls. No significant difference in cell viability was detected between ES and non-stimul","[373, 749, 1147, 840]",figure_caption,0.92,"[""figure_title label: Figure 3 Cell viability. Measured by MTT assay, compared bet""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,3,paragraph_title,Cell viability and activity,"[363, 870, 651, 899]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,4,text,"MTT assay was performed to compare viability and activity of electrically stimulated cells vs. non-stimulated controls. None of the cells exposed to 10, 50 and 100 mV/mm showed signs of toxicity. Figu","[360, 903, 1155, 1170]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,paragraph_title,Osteogenic differentiation,"[363, 1187, 669, 1215]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Osteogenic differentiation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,6,text,The influence of electrical stimulation on osteogenic differentiation of rat AT- and BM-MSCs in culture were investigated after seven and 14 days and compared to controls. Figures 2A and 2B shows Aliz,"[361, 1219, 1146, 1427]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63, 1501, 496, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +7,8,number,7/15,"[1117, 1502, 1158, 1523]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,PeerJ,"[61, 71, 156, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +8,1,text,"(10 and 50 mV/mm) electrical fields, was not significant. However, initial morphological changes in both cell types were present at day 7, in cells exposed to electrical field of 50 mV/mm (Figs. 2C an","[362, 167, 1153, 252]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,2,text,"Osteogenic phenotype gene expression was investigated by means of RT-qPCR analysis, in both ES and control groups of AT-MSCs and BM-MSCs at three, seven, and 14 days, (Fig. 4). In both BM- and AT-MSCs","[361, 256, 1161, 608]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,paragraph_title,DISCUSSION,"[364, 629, 546, 659]",section_heading,0.9,"[""explicit scholarly heading: DISCUSSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +8,4,text,Early studies exposing bone cells to DC electrical fields were in 1980s when Ferrier et al. (1986) exposed osteoblast-like cells to a 100 mV/mm electrical stimulation and observed cell migration towar,"[361, 674, 1161, 1054]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"With the aim of better understanding these DC ES induced changes in MSCs osteogenic differentiation behavior, we exposed rat BM-MSCs and AT-MSCs to 100 mV/mm 1 h/day DC ES for three, seven and 14 days","[362, 1057, 1161, 1378]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"We showed that in the presence of DC ES, BM-MSCs and AT-MSCs behave differently as it relates to osteogenic marker expression. These observations could be related to","[362, 1382, 1159, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63, 1501, 496, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +8,8,number,8/15,"[1117, 1502, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,PeerJ,"[61, 71, 155, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +9,1,vision_footnote,"No Electrical Stimulation +Electrical Stimulation 100 mV/mm","[449, 168, 738, 219]",footnote,0.7,"[""vision_footnote label: No Electrical Stimulation\nElectrical Stimulation 100 mV/mm""]",footnote,0.7,body_zone,unknown_like,none,True,True +9,2,chart,,"[429, 237, 733, 485]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,3,chart,,"[772, 238, 1071, 484]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,4,chart,,"[363, 504, 742, 757]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +9,5,chart,,"[766, 503, 1075, 750]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,chart,,"[428, 774, 729, 1016]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,7,chart,,"[765, 768, 1075, 1013]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,8,figure_title,Days post culture in osteogenic differentiation supplemented medium,"[374, 1046, 1143, 1077]",figure_caption_candidate,0.85,"[""figure_title label: Days post culture in osteogenic differentiation supplemented""]",figure_caption,0.85,body_zone,legend_like,none,False,False +9,9,text,"Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2, (B) Osteopontin, (C) Collagen Type1 (Col1A2) in BM-MSCs; (D) Runx2, (E) Osteopontin and (F) Col1A2 in AT-MSCs, in both ","[373, 1101, 1143, 1258]",figure_caption,0.9,"[""figure prefix matched: Figure 4 RT-qPCR results. Temporal changes in messenger RNA "", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +9,10,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64, 1501, 495, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +9,11,number,9/15,"[1117, 1502, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,PeerJ,"[61, 71, 156, 108]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +10,1,text,"the known differences in osteogenic differentiation capacity between BM- and AT-derived MSC. Namely, studies that suggest AT-MSCs have less osteogenic potential than BM-MSCs (Ratanavaraporn et al., 20","[361, 167, 1162, 313]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,2,text,"Our results indicate that in control groups (osteogenic supplemented medium, without electrical stimulation), both in BM- and AT-MSCs, only a slight difference exists in temporal expression patterns o","[362, 317, 1161, 462]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,text,"Runx2 is known as a master osteogenic transcription factor. Runx2 activates and regulates osteogenesis as the targeted gene of many signaling pathways, including transforming growth factor-beta 1 (TGF","[361, 465, 1161, 914]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,paragraph_title,CONCLUSIONS,"[364, 939, 578, 970]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSIONS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +10,5,text,"We have demonstrated that DC ES promotes Runx2, Osteopontin and Col1A2 expression in BM-MSCs already at 7 days. Our results indicate that DC ES effects osteogenic gene expression, in both BM- and AT-M","[361, 983, 1158, 1192]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,paragraph_title,ADDITIONAL INFORMATION AND DECLARATIONS,"[371, 1224, 1050, 1256]",body_paragraph,0.5,"[""backmatter boundary candidate: ADDITIONAL INFORMATION AND DECLARATIONS""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True +10,7,paragraph_title,Funding,"[364, 1287, 466, 1316]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Funding""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,8,text,"The work described herein was supported in part by a grant from the AO Foundation (#S-14-03H) and from the Friedrichsheim Foundation (Stiftung Friedrichsheim) in Frankfurt/Main, Germany. The funders h","[362, 1319, 1149, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,9,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64, 1501, 496, 1524]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False +10,10,number,10/15,"[1108, 1502, 1158, 1523]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,PeerJ,"[62, 72, 155, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +11,1,paragraph_title,Grant Disclosures,"[364, 164, 578, 191]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Grant Disclosures""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,2,text,"The following grant information was disclosed by the authors: +AO Foundation: #S-14-03H. +Friedrichsheim Foundation.","[363, 197, 917, 280]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,3,paragraph_title,Competing Interests,"[364, 303, 604, 330]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing Interests""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,4,text,The authors declare there are no competing interests.,"[363, 336, 838, 361]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,paragraph_title,Author Contributions,"[365, 380, 614, 406]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author Contributions""]",subsection_heading,0.6,body_zone,support_like,none,True,True +11,6,text,"● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.","[364, 413, 1158, 497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"- Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figures and/or tables.","[364, 502, 1157, 556]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,8,text,"● John Howard Barker contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.","[365, 563, 1138, 618]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,paragraph_title,Data Availability,"[365, 637, 556, 665]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data Availability""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,10,text,The following information was supplied regarding data availability:,"[364, 670, 961, 696]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,text,The raw data has been supplied as Supplementary Files.,"[388, 701, 884, 726]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,12,paragraph_title,Supplemental Information,"[364, 745, 667, 774]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supplemental Information""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +11,13,text,Supplemental information for this article can be found online at http://dx.doi.org/10.7717/peerj.2821#supplemental-information.,"[363, 778, 1158, 835]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,14,paragraph_title,REFERENCES,"[365, 874, 562, 904]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +11,15,reference_content,"Amini AR, Laurencin CT, Nukavarapu SP. 2012. 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The effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell differentiation.","[371, 795, 1112, 908]",reference_item,0.85,"[""reference content label: Ross CL, Siriwardane M, Almeida-Porada G, Porada CD, Brink P""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +14,8,reference_content,Ryaby JT. 1998. Clinical effects of electromagnetic and electric fields on fracture healing. Clinical Orthopaedics and Related Research 355:S205–S215.,"[369, 914, 1145, 969]",reference_item,0.85,"[""reference content label: Ryaby JT. 1998. Clinical effects of electromagnetic and elec""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +14,9,reference_content,"Shamos MH, Lavine LS, Shamos MI. 1963. Piezoelectric effect in bone. Nature 197:81.","[367, 974, 1136, 1001]",reference_item,0.85,"[""reference content label: Shamos MH, Lavine LS, Shamos MI. 1963. Piezoelectric effect ""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +14,10,reference_content,"Sun LY, Hsieh DK, Yu TC, Chiu HT, Lu SF, Luo GH, Kuo TK, Lee OK, Chiou TW. 2009. Effect of pulsed electromagnetic field on the proliferation and differentiation potential of human bone marrow mesenchy","[369, 1003, 1137, 1118]",reference_item,0.85,"[""reference content label: Sun LY, Hsieh DK, Yu TC, Chiu HT, Lu SF, Luo GH, Kuo TK, Lee""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +14,11,reference_content,"Tandon N, Cannizzaro C, Chao PH, Maidhof R, Marsano A, Au HT, Radisic M, Vunjak-Novakovic G. 2009a. Electrical stimulation systems for cardiac tissue engineering. Nature Protocols 4:155–173 DOI 10.103","[370, 1124, 1091, 1209]",reference_item,0.85,"[""reference content label: Tandon N, Cannizzaro C, Chao PH, Maidhof R, Marsano A, Au HT""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +14,12,reference_content,"Tandon N, Goh B, Marsano A, Chao PH, Montouri-Sorrentino C, Gimble J, Vunjak Novakovic G. 2009b. Alignment and elongation of human adipose-derived stem cells in response to direct-current electrical s","[370, 1214, 1133, 1355]",reference_item,0.85,"[""reference content label: Tandon N, Goh B, Marsano A, Chao PH, Montouri-Sorrentino C, ""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +14,13,reference_content,"Tofail SAM, Zhang Y, Gandhi AA. 2011. Piezoelectricity of bone from a new perspective. In: 2011 14th international symposium on electrets (Ise), 91–92.","[369, 1362, 1154, 1418]",reference_item,0.85,"[""reference content label: Tofail SAM, Zhang Y, Gandhi AA. 2011. Piezoelectricity of bo""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +14,14,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64, 1501, 494, 1524]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_pattern,False,False +14,15,number,14/15,"[1109, 1503, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,0,header,PeerJ,"[62, 72, 155, 107]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,1,reference_content,"Tsai MT, Li WJ, Tuan RS, Chang WH. 2009. Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation. Journal of Orthopaedic Research 27:1169–1174 D","[371, 168, 1149, 252]",reference_item,0.85,"[""reference content label: Tsai MT, Li WJ, Tuan RS, Chang WH. 2009. Modulation of osteo""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +15,2,reference_content,"Zhao Z, Watt C, Karystinou A, Roelofs AJ, McCaig CD, Gibson IR, De Bari C. 2011. Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field. Europe","[370, 258, 1114, 368]",reference_item,0.85,"[""reference content label: Zhao Z, Watt C, Karystinou A, Roelofs AJ, McCaig CD, Gibson ""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +15,3,reference_content,"Zhuang H, Wang W, Seldes RM, Tahernia AD, Fan H, Brighton CT. 1997. Electrical stimulation induces the level of TGF- $ \beta $1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin p","[370, 377, 1136, 490]",reference_item,0.85,"[""reference content label: Zhuang H, Wang W, Seldes RM, Tahernia AD, Fan H, Brighton CT""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True +15,4,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64, 1502, 495, 1524]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_pattern,False,False +15,5,number,15/15,"[1108, 1503, 1158, 1522]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/2H8MZ27H/block_trace.csv b/tests/fixtures/ocr_real_papers/2H8MZ27H/block_trace.csv new file mode 100644 index 00000000..f58a83d0 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/2H8MZ27H/block_trace.csv @@ -0,0 +1,205 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[38, 36, 368, 196]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header_image,,"[603, 1, 1188, 199]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,text,OPEN,"[157, 300, 243, 331]",authors,0.6,"[""page-1 initial-lastname author byline: OPEN""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,3,text,"SUBJECT AREAS: +BIONANOELECTRONICS +BIOLOGICAL MODELS","[68, 381, 244, 466]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,doc_title,Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/ $ \beta $-catenin Signaling Pathway,"[282, 283, 1048, 521]",paper_title,0.8,"[""page-1 zone title_zone: Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotyp""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,Received 12 December 2013,"[91, 503, 244, 550]",frontmatter_noise,0.7,"[""frontmatter noise text: Received 12 December 2013""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,6,text,Accepted,"[164, 560, 244, 583]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Accepted""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,short_fragment,False,False +1,7,text,8 July 2014,"[147, 582, 243, 607]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,reference_like,reference_numeric_dot,False,False +1,8,text,Published,"[150, 614, 244, 638]",frontmatter_noise,0.7,"[""frontmatter noise text: Published""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False +1,9,text,25 July 2014,"[137, 637, 244, 663]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,reference_like,reference_numeric_dot,False,False +1,10,text,"Correspondence and requests for materials should be addressed to Z.G.G. (gez@pku.edu.cn) or J.Z. (zhangjue@pku.edu.cn) +Kun Zhang $ ^{1} $, Jinsong Guo $ ^{2} $, Zigang Ge $ ^{1,3,4} $ & Jue Zhang $ ^{","[81, 712, 246, 858]",frontmatter_support,0.78,"[""first-surviving-page support text: Correspondence and requests for materials should be addresse""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True +1,11,text,"Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5","[282, 535, 743, 564]",authors,0.8,"[""page-1 zone author_zone: Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,12,text," $ ^{1} $Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China, $ ^{2} $Institute of Biomechaics and Biomedical Engineering, College of Engineering, P","[281, 598, 1110, 703]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $Department of Biomedical Engineering, College of Eng""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,13,abstract,"Nanosecond pulsed electric fields (nsPEFs) characterized by high voltage, low energy and non-thermal effects, have been broadly investigated as a potential tumor therapy; however, little is known abou","[280, 737, 1111, 947]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,14,text,"M illisecond or microsecond pulsed electric fields (PEFs) have been shown to facilitate delivery of drugs and transfer of genes into cells $ ^{1,2} $. PEFs induce a transient transmembrane potential o","[281, 977, 1111, 1297]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,text,"Chondrocytes are critical for maintenance and regeneration of cartilage, and several signaling pathways regulate phenotypes of differentiation, hypertrophy, proliferation, and dedifferentiation. Trans","[281, 1297, 1112, 1492]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82, 1520, 517, 1542]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,17,number,1,"[1094, 1523, 1107, 1541]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,0,header,www.nature.com/scientificreports,"[761, 30, 1109, 53]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[1125, 1, 1191, 74]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +2,2,image,,"[79, 96, 581, 552]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,3,figure_title,Figure 1 | Strategic map exploring the effects of nsPEFs on chondrocytes.,"[80, 566, 587, 590]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 1 | Strategic map exploring the effects of nsPEFs on ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +2,4,text,"ments were used in the aforementioned research due to the thermal effects of PEFs. Although the biological effects induced by nsPEFs are largely unknown, it has been reported that MAPK pathways, gener","[79, 614, 588, 743]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"In this study, we evaluated the phenotypic effects of nsPEFs on chondrocytes and found that nsPEFs enhanced cell proliferation while causing dedifferentiation by upregulating gene expression of type I","[80, 743, 589, 832]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"II. We then explored whether activation of the wnt/b-catenin signal- +ing pathway was involved in these phenotypic changes (Fig. 1).","[602, 99, 1108, 146]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,Results,"[602, 163, 681, 185]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True +2,8,text,"nsPEFs enhance proliferation of chondrocytes. Based on favorable results obtained in previous reports and our pilot study, 5 pulses of 100 ns nsPEFs at 10 or 20 kV/cm were used in this current study $","[600, 187, 1111, 525]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"nsPEFs downregulate glycosaminoglycan (GAG) production. Results obtained demonstrated that nsPEFs at 10 kV/cm decreased GAG production at day 1 (0.91-fold), day 3 (0.96-fold) and day 7 (0.97-fold). Mo","[600, 538, 1111, 773]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,nsPEFs downregulate expression of functional genes. Effects of nsPEFs on gene expression were evaluated at 1 hour and 24 hours,"[601, 784, 1112, 830]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,chart,,"[232, 867, 581, 1110]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,12,figure_title,b,"[611, 857, 636, 889]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +2,13,chart,,"[610, 869, 954, 1108]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,14,chart,,"[237, 1134, 581, 1378]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,15,chart,,"[605, 1131, 954, 1377]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,16,figure_title,"Figure 2 | Induction of dedifferentiated phenotype of chondrocytes after nsPEF treatment. (a) The toxicity of nsPEFs at 10 kV/cm and 20 kV/cm was evaluated at days 1, 3 and 7. nsPEFs had a nontoxic ef","[80, 1388, 1110, 1497]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 2 | Induction of dedifferentiated phenotype of chondr""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +2,17,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82, 1520, 518, 1542]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,18,number,2,"[1092, 1522, 1110, 1541]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,www.nature.com/scientificreports,"[761, 30, 1109, 54]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[1125, 1, 1191, 75]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +3,2,figure_title,a,"[218, 112, 242, 137]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,3,chart,,"[219, 114, 581, 369]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,b,"[606, 105, 630, 137]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,5,chart,,"[606, 110, 976, 368]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,C,"[218, 387, 241, 414]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,7,chart,,"[220, 389, 582, 641]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,8,chart,,"[607, 383, 976, 642]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,9,figure_title,e,"[216, 656, 242, 682]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,10,chart,,"[211, 666, 580, 911]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,11,figure_title,Figure 3 | Functional gene expression of chondrocytes after nsPEF treatment. Gene expression was analyzed at 1 hour for immediate effects and following a recovery period of 24 hours after 10 kV/cm and,"[78, 924, 1107, 1011]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 3 | Functional gene expression of chondrocytes after ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +3,12,text,"after nsPEF treatment. At 1 hour, nsPEFs at 10 kV/cm decreased gene expression of COL II significantly to 0.43-fold (p = 0.017), while nsPEFs at 20 kV/cm decreased COL II gene expression to 0.45-fold ","[79, 1033, 588, 1286]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,text,"At 24 hours after nsPEF treatment, gene expression showed an increase compared to the gene expression at 1 hour. An additive effect of COL I was indicated by an increase in the gene expression to 1.75","[79, 1287, 588, 1434]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,text,"nsPEFs activate wnt/β-catenin signaling pathway. Expression of β-catenin protein increased significantly by 45% (p = 0.005) and 42% (p = 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment, resp","[80, 1453, 588, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,text,"(p 5 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment, +respectively (Fig. 4a, b). As shown, b-catenin accumulated in the +nucleus of the cells after nsPEF treatment (Fig. 4c). 10 kV/cm and +20 ","[601, 1033, 1111, 1288]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,16,text,"Our findings demonstrated that after 24 hours, nsPEFs induced a decrease in Lef1 and c-jun gene expression in comparison to the gene expression observed after 1 hour. nsPEFs increased gene expression ","[601, 1287, 1111, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,17,text,Inhibition of wnt/ $ \beta $-catenin pathway partially blocks effects of nsPEFs. Incubation with XAV939 reverted nsPEF-induced upregulation of $ \beta $-,"[601, 1453, 1109, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,18,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82, 1521, 517, 1542]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,19,number,3,"[1093, 1523, 1109, 1541]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,www.nature.com/scientificreports,"[761, 31, 1109, 53]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header_image,,"[1126, 1, 1191, 75]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +4,2,chart,,"[109, 114, 324, 272]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,3,chart,,"[364, 103, 577, 322]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,4,image,,"[102, 333, 550, 760]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,5,figure_title,Figure 4 | Activated wnt/β-catenin signaling pathway after nsPEF treatment. (a) β-catenin protein expression performed with western blotting analysis using specific antibodies for β-catenin at 1 hour ,"[80, 776, 588, 966]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 4 | Activated wnt/\u03b2-catenin signaling pathway after n""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +4,6,text,"catenin (Fig. 6j–6l), wnt7a gene (Fig. 6d) and the downstream genes of wnt, Lef1 (Fig. 6a), c-jun (Fig. 6b) and cyclin D1 (Fig. 6c) by inhibition ranging from 30% to 60%. When the effects of inhibitio","[79, 989, 588, 1307]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,paragraph_title,Discussion,"[81, 1326, 190, 1347]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,8,text,nsPEFs have profound effects on multiple organelles of a cell. nsPEFs generate large transmembrane potentials across cellular organelles with limited thermal effects. The most significant characterist,"[79, 1348, 589, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,"pulse duration decreases, the outer membrane is likely shorted, and +the applied voltage appears mainly across the interior organelles of +the cell27. nsPEFs modify the potential and phosphatidylserine ","[602, 100, 1112, 312]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,"Effects of nsPEFs are usually transient. Typically, the nanopores can be formed within 5 nanoseconds after nsPEF treatment $ ^{7} $. Calcium ions efflux from the endoplasmic reticulum within 10 second","[601, 314, 1111, 630]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,Fine-tuned activation of the wnt/β-catenin signaling pathway is essential to regulate the fate of chondrocytes in cartilage. The wnt/β-catenin pathway is involved in dedifferentiation of cultured chon,"[602, 629, 1111, 1074]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,The fact that inhibition of the wnt/ $ \beta $-catenin signaling can only partially block the effects of nsPEFs on chondrocytes hints that there are other mechanisms involved. The functional crosstalk,"[601, 1073, 1112, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82, 1520, 517, 1542]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,14,number,4,"[1093, 1523, 1109, 1541]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,www.nature.com/scientificreports,"[761, 30, 1110, 54]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header_image,,"[1125, 1, 1191, 75]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +5,2,chart,,"[251, 111, 587, 354]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,b,"[597, 104, 620, 136]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,4,chart,,"[597, 111, 934, 353]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,chart,,"[255, 370, 589, 613]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,figure_title,d,"[597, 365, 622, 395]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,7,chart,,"[593, 372, 935, 611]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,figure_title,"Figure 5 | Influence of nsPEFs on gene expression related to wnt/ $ \beta $-catenin signaling. Gene expression was detected immediately at 1 hour and following a 24 hour recovery after 0, 10 and 20 kV","[80, 623, 1109, 688]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 5 | Influence of nsPEFs on gene expression related to""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +5,9,text,"due to its folded spiral structure, it is sensitive to nsPEFs and forms speckles after nsPEF treatment $ ^{28} $. nsPEFs induce small nuclear ribonucleoprotein particles and RNA-protein complexes, whi","[79, 710, 588, 987]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"nsPEFs may have different effects on suspended and attached cells in vitro. Cells in a suspended state were subjected to nsPEFs within electric cuvettes, which provided an instantaneous and consistent","[79, 987, 589, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,"development of a real-time visual microfluidic system for monitoring +adherent cells combined with nsPEFs52.","[601, 710, 1110, 753]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,text,"As nsPEFs do not exist in a natural cellular environment, a comprehensive understanding of nsPEFs as well as the effects of superficial stimuli need to be further explored to determine any difference ","[600, 756, 1112, 1011]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,paragraph_title,Methods,"[603, 1042, 696, 1064]",section_heading,0.9,"[""explicit scholarly heading: Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +5,14,text,"Cell culture. Porcine articular cartilage tissue was cut into small pieces by a lancet, and washed with phosphate-buffered saline (PBS). The tissue pieces were collected and digested in 0.1% Collagena","[601, 1069, 1110, 1313]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,15,text,"Application of nsPEFs. The nsPEF generator was applied as previously described $ ^{54} $. Digital phosphor oscilloscope (DPO4054, Tektronix) with a probe (P6015A, Tektronix) was utilized to monitor th","[601, 1339, 1112, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,16,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82, 1521, 517, 1542]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,17,number,5,"[1093, 1523, 1108, 1541]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,www.nature.com/scientificreports,"[762, 30, 1109, 53]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header_image,,"[1125, 1, 1190, 75]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +6,2,chart,,"[102, 104, 287, 319]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,3,chart,,"[302, 112, 493, 320]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,4,chart,,"[500, 111, 701, 319]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,chart,,"[703, 113, 899, 319]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,6,chart,,"[902, 119, 1101, 320]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,7,chart,,"[89, 344, 289, 545]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,chart,,"[294, 342, 494, 545]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,chart,,"[502, 344, 704, 544]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,10,chart,,"[717, 341, 918, 544]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,11,figure_title,j,"[105, 571, 120, 602]",figure_inner_text,0.9,"[""panel label / figure inner text: j""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,12,image,,"[101, 569, 352, 778]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,13,chart,,"[376, 573, 578, 788]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,14,chart,,"[611, 561, 860, 796]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,15,image,,"[612, 559, 1065, 796]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,16,figure_title,"Figure 6 | Influence of inhibition of wnt/ $ \beta $-catenin signaling on gene and protein expression after nsPEF treatment. Gene expression was detected at 1 hour after 0, 10 and 20 kV/cm nsPEF treat","[77, 812, 1112, 960]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 6 | Influence of inhibition of wnt/ $ \\beta $-catenin""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +6,17,text,"Celltoxicity. The toxicity of nsPEFs was evaluated by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT, M2128, Sigma) at days 1, 3 and 7.5.0 × 10³ chondrocytes/well were seeded in","[80, 982, 589, 1121]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,18,text,"Cell proliferation. Cell proliferation was assayed with Hoechst 33258 (H6024, Sigma) at days 1, 3 and 7. Chondrocytes in each well were lysed with 100 μL sterile distilled DNAse-free H₂O, and the diss","[80, 1135, 587, 1258]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,19,text,"GAG content. Chondrocytes were digested in 0.5 mg/mL proteinase K at 56°C for 12 hours, and were subsequently examined with dimethylmethylene blue (DMMB, 341088, Sigma). The digestive solution was sha","[79, 1272, 587, 1396]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,20,text,"Gene expression. Total RNA was extracted and isolated from chondrocytes with Trizol Reagent (206101, New Industry) following the standard protocol, and quantified with Nanodrop spectrophotometer (ND-1","[80, 1409, 588, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,21,text,"cycler (Mycycler, Bio-Rad). Quantitative real-time PCR was performed in the PCR +system (Pikoreal 96, Thermo) with RealMasterMix SYBR Green (FP202, Tiangen) +following the manufacturer’s procedures. The","[601, 982, 1111, 1374]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,22,text,"Western blotting. Chondrocytes were lysed by RIPA lysis buffer (R0020, Solarbio) with fresh protease inhibitor of 0.1% phenylmethanesulfonyl fluoride (PMSF, Solarbio). Total cell lysate was boiled aft","[602, 1391, 1108, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,23,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82, 1521, 517, 1542]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,24,number,6,"[1093, 1523, 1109, 1541]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,www.nature.com/scientificreports,"[761, 31, 1109, 53]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,1,header_image,,"[1125, 1, 1190, 74]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +7,2,text,"and $ \beta $-actin (4970, Cell Signaling) was combined with HRP-linked antibody of anti-rabbit IgG (7074, Cell Signaling). The complex of the antigen and the antibody was illuminated by chemilumines","[89, 98, 591, 171]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"Immunofluorescence. Immunofluorescence was utilized to confirm the location of $ \beta $-catenin protein. After nsPEF treatment, chondrocytes were fixed with 4% paraformaldehyde for 15 minutes and wa","[81, 189, 586, 329]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,Statistical analysis. Analysis was performed using SPSS V13.0 (SPSS Inc.) one-way ANOVA with the least significant difference (LSD) test (data presented as mean ± s.d). The statistical significance wa,"[81, 348, 585, 419]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,reference_content,"1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Membrane electroporation theories: a review. Med. Biol. Eng. Comput. 44, 5–14 (2006).","[82, 452, 586, 486]",reference_item,0.85,"[""reference content label: 1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Mem""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,6,reference_content,"2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Nanosecond Pulsed Electric Fields into He La Cells Expressing Enhanced Green Fluorescent Protein and Fluorescence Lifetime Microscopy. J. Phys","[83, 487, 586, 553]",reference_item,0.85,"[""reference content label: 2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Na""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,7,reference_content,"3. Weaver, J. C. Electroporation of biological membranes from multicellular to nano scales. IEEE Trans. Dielectr. Electr. Insul. 10, 754–768 (2003).","[83, 556, 587, 590]",reference_item,0.85,"[""reference content label: 3. 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Nanosecond pulsed el""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,17,reference_content,"13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. & Stacey, M. W. Enhanced Killing Effect of Nanosecond Pulse Electric Fields on PANC1 and Jurkat Cell Lines in the Presence of Tween 80. The ","[85, 1010, 587, 1076]",reference_item,0.85,"[""reference content label: 13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,18,reference_content,"14. van der Kraan, P. M., Davidson, E. N. B., Blom, A. & van den Berg, W. B. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis Modulation and integration of signaling pathw","[84, 1079, 585, 1146]",reference_item,0.85,"[""reference content label: 14. van der Kraan, P. M., Davidson, E. N. 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Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocyte phenotype by beta-catenin. Mol Biol Cell 13, 118a–118a (2002).","[85, 1252, 575, 1287]",reference_item,0.85,"[""reference content label: 17. Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocy""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,22,reference_content,"18. Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. Chem. 280, 21653–21660 (2","[85, 1289, 586, 1338]",reference_item,0.85,"[""reference content label: 18. Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metallop""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,23,reference_content,"19. Fini, M. et al. Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation? 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Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2 alpha phosphory","[604, 151, 1108, 219]",reference_item,0.85,"[""reference content label: 23. Morotomi-Yano, K., Oyadomari, S., Akiyama, H. & Yano, K.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,28,reference_content,"24. Ge, Z. G., Baguenard, S., Lim, L. Y., Wee, A. & Khor, E. Hydroxyapatite-chitin materials as potential tissue engineered bone substitutes. Biomaterials 25, 1049–1058 (2004).","[606, 219, 1100, 269]",reference_item,0.85,"[""reference content label: 24. Ge, Z. G., Baguenard, S., Lim, L. Y., Wee, A. & Khor, E.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,29,reference_content,"25. Schoenbach, K. H., Katsuki, S., Stark, R. H., Buescher, E. S. & Beebe, S. J. Bioelectrics - New applications for pulsed power technology. IEEE Trans. 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Cell responses without receptors and ligand""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +7,58,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[83, 1521, 517, 1541]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +7,59,number,7,"[1093, 1523, 1108, 1540]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +8,0,header,www.nature.com/scientificreports,"[762, 31, 1109, 53]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +8,1,header_image,,"[1126, 1, 1190, 74]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +8,2,text,"54. Wang, J. et al. Synergistic Effects of Nanosecond Pulsed Electric Fields Combined with Low Concentration of Gemcitabine on Human Oral Squamous Cell Carcinoma In Vitro. PLoS One 7 (2012).","[82, 99, 587, 153]",reference_item,0.6,"[""reference-like pattern: 54. Wang, J. et al. Synergistic Effects of Nanosecond Pulsed""]",reference_item,0.6,reference_zone,reference_like,reference_numeric_dot,True,True +8,3,paragraph_title,Acknowledgments,"[82, 198, 270, 220]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +8,4,text,"This work was supported by National Basic Research Program of China (973 Program) (2012CB619100), and National Natural Science Foundation of China grant (81271722). The authors would like to thank A. ","[80, 220, 587, 291]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,5,paragraph_title,Author contributions,"[81, 313, 286, 333]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True +8,6,text,"Z.G. and J.Z. designed this study, whereas K.Z. and J.G. were involved in the experimentation. K.Z. and Z.G. analyzed data and wrote the manuscript with assistance from J.G. and J.Z. All authors revie","[81, 334, 578, 388]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,7,paragraph_title,Additional information,"[604, 100, 829, 122]",backmatter_heading,0.5,"[""backmatter boundary candidate: Additional information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True +8,8,text,Supplementary information accompanies this paper at http://www.nature.com/scientificreports,"[602, 122, 1057, 158]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,9,text,Competing financial interests: The authors declare no competing financial interests.,"[602, 163, 1083, 181]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,10,text,"How to cite this article: Zhang, K., Guo, J., Ge, Z. & Zhang, J. Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/ $ \beta $-catenin Signaling Pathway. Sci. R","[602, 186, 1108, 241]",frontmatter_noise,0.8,"[""frontmatter phrase: How to cite this article: Zhang, K., Guo, J., Ge, Z. & Zhang""]",frontmatter_noise,0.8,,unknown_like,none,False,False +8,11,text,"This work is licensed under a Creative Commons Attribution 4.0 International +License. The images or other third party material in this article are included in the +article’s Creative Commons license, u","[685, 258, 1111, 365]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,12,image,,"[605, 261, 683, 290]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +8,13,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82, 1520, 517, 1542]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,14,number,8,"[1093, 1522, 1109, 1541]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/2HEUD5P9/block_trace.csv b/tests/fixtures/ocr_real_papers/2HEUD5P9/block_trace.csv new file mode 100644 index 00000000..fa388c51 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/2HEUD5P9/block_trace.csv @@ -0,0 +1,778 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,REVIEW,"[98, 53, 210, 81]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header_image,,"[1037, 2, 1190, 27]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,2,header,"small methods +www.small-methods.com","[901, 38, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,3,doc_title,Application of Bioactive Materials for Osteogenic Function in Bone Tissue Engineering,"[96, 147, 1065, 238]",paper_title,0.8,"[""page-1 zone title_zone: Application of Bioactive Materials for Osteogenic Function i""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"Yuxin Bai, Zhaojie Wang, Xiaolie He, Yanjing Zhu, Xu Xu, Huiyi Yang, Guangyu Mei, Shengguang Chen,* Bei Ma,* and Rongrong Zhu*","[96, 268, 1035, 340]",authors,0.8,"[""page-1 zone author_zone: Yuxin Bai, Zhaojie Wang, Xiaolie He, Yanjing Zhu, Xu Xu, Hui""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,abstract,Bone tissue defects present a major challenge in orthopedic surgery. Bone tissue engineering using multiple versatile bioactive materials is a potential strategy for bone-defect repair and regeneratio,"[114, 403, 761, 821]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,6,paragraph_title,1. Introduction,"[98, 874, 246, 899]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,7,text,Bone is a connective tissue that contains collagen as the organic component and calcium phosphate (CaP) as the inorganic,"[95, 913, 588, 961]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,"component. Bone tissue defects, infections, illnesses, and dislocations can impair the quality of life of a patient.[1] Autograft and allograft techniques are often used to treat bone-related diseases","[781, 389, 1099, 870]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,9,footnote,"Y. Bai, Z. Wang, X. He, Y. Zhu, X. Xu, H. Yang, G. Mei, S. Chen, B. Ma, R. Zhu +Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education +Department of Orthopedics","[96, 993, 584, 1365]",footnote,0.7,"[""footnote label: Y. Bai, Z. Wang, X. He, Y. Zhu, X. Xu, H. Yang, G. Mei, S. C""]",footnote,0.7,body_zone,body_like,none,True,True +1,10,text,"Bone regeneration requires effective solutions for bone loss and defects, which are prominent clinical challenges in orthopedic surgery. Bone tissue engineering and regeneration offer a promising appr","[605, 871, 1099, 1177]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,text,Stem cells effectively promote bone regeneration by differentiating into osteoblasts and chondrocytes. Cartilage serves as a template for subsequent bone formation via endochondral ossification.[9] Th,"[605, 1178, 1099, 1443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,12,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smtd.202301283,"[99, 1375, 588, 1414]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,13,footer,DOI: 10.1002/smtd.202301283,"[97, 1420, 336, 1443]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,14,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,15,footer,2301283 (1 of 27),"[530, 1484, 664, 1508]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,16,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[896, 36, 1091, 117]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,2,text,"specific differentiation pathways, thereby improving bone healing and osteogenesis. $ ^{[12]} $ Therefore, scaffolds should possess a considerable capacity for the delivery of these factors. In additi","[89, 148, 582, 281]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Bioactive composite 3D porous scaffolds can improve the outcomes of bone-defect repair, including osteoconduction (bone cell infiltration into scaffolds), osseointegration (firm attachment of scaffold","[89, 281, 582, 676]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,Osteoconductivity and osteoinductivity of biomaterials has significant importance in clinical applications. The design of bone tissue engineering materials requires an understanding of the composition,"[90, 675, 582, 1158]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Multiple biomaterials have been used in bone tissue repair and regeneration to date, largely owing to their unique properties. This review summarizes several biomaterials and advanced techniques and i","[89, 1157, 583, 1402]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,paragraph_title,2. Main Types of Bone Biomaterials,"[601, 149, 945, 176]",paper_title,0.6,"[""page-1 frontmatter title guard: 2. Main Types of Bone Biomaterials""]",paper_title,0.6,frontmatter_main_zone,reference_like,reference_numeric_dot,True,True +2,7,paragraph_title,2.1. Ceramics,"[602, 187, 711, 210]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Ceramics""]",subsection_heading,0.85,frontmatter_side_zone,support_like,heading_numbered,True,True +2,8,text,"Ceramics, which are non-metallic inorganic biomaterials, have been widely proposed for cell osteogenic differentiation and bone regeneration.[20] Bioactive ceramics, such as CaP ceramics and bioactive","[600, 231, 1092, 695]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,paragraph_title,2.1.1. Hydroxyapatite,"[603, 717, 763, 740]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.1. Hydroxyapatite""]",subsection_heading,0.85,frontmatter_side_zone,support_like,heading_numbered,True,True +2,10,text,"HAP is one of the most extensively used CaP ceramics in bone repair and regeneration because of its similarity to the components of human bone minerals.[27,28] HAP with the capability of osteoconducti","[600, 759, 1093, 1177]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,text,"HAP has some drawbacks compared with other CaP ceramics, including poor mechanical properties and low degradability. Therefore, HAP is often mixed with polymers to yield composite scaffolds with impro","[599, 1176, 1093, 1399]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,13,number,2301283 (2 of 27),"[524, 1484, 658, 1508]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,14,footer,© 2024 Wiley-VCH GmbH,"[931, 1486, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,15,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smd.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:/","[1153, 30, 1172, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 44, 345, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[901, 36, 1097, 118]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,2,image,,"[237, 157, 955, 847]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,Figure 1. The schematic diagram of bioactive materials and advanced techniques to regulate the stem cell fate with specific cellular and molecular mechanism for the application of bone tissue engineer,"[97, 864, 1097, 906]",figure_caption,0.92,"[""figure_title label: Figure 1. The schematic diagram of bioactive materials and a""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,"biocompatibility, superior mechanical properties and excellent osteoconductivity, both in vitro and in vivo, and scaffolds combined with BMSCs significantly promoted new bone formation. $ ^{[31]} $ Mo","[95, 937, 588, 1161]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,2.1.2. Tricalcium Phosphate,"[98, 1202, 301, 1224]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.2. Tricalcium Phosphate""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,6,text,"HAP with a high crystallinity is relatively difficult to degrade in vivo, whereas TCP is more easily degraded and has a higher solubility. TCP combined with HAP in different proportions within composi","[95, 1245, 588, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"application in bone scaffolds. By contrast, 𝛽-TCP is more stable. +After degradation, 𝛽-TCP promotes mineralization by releasing +calcium and phosphate ions. Furthermore, 𝛽-TCP displays good +biocompatibi","[605, 937, 1097, 1070]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,β-TCP can be prepared using two methods: high-temperature solid-phase reaction and room-temperature wet method. The high-temperature solid-phase reaction method typically involves mixing CaHPO₄·2H₂O a,"[604, 1071, 1099, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,10,number,2301283 (3 of 27),"[530, 1484, 664, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,11,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,12,aside_text,"2369608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smk.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https://","[1153, 29, 1172, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +4,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[91, 45, 340, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header,"small methods +www.small-methods.com","[895, 36, 1092, 118]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,figure_title,(A),"[105, 155, 143, 183]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,3,image,,"[121, 203, 311, 374]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,4,figure_title,(B),"[432, 151, 473, 181]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,5,figure_title,(E),"[105, 377, 142, 407]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,6,image,,"[333, 204, 421, 375]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,7,chart,,"[421, 200, 656, 398]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,8,figure_title,(c),"[675, 151, 715, 181]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,9,image,,"[657, 179, 848, 414]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,10,figure_title,(D),"[884, 151, 923, 180]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,11,image,,"[887, 186, 969, 296]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,12,image,,"[973, 184, 1061, 296]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,13,image,,"[886, 303, 967, 411]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,14,image,,"[967, 303, 1058, 412]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,15,image,,"[103, 434, 607, 734]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,16,figure_title,(H),"[660, 428, 698, 458]",figure_inner_text,0.9,"[""panel label / figure inner text: (H)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,17,image,,"[618, 431, 1085, 687]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,18,figure_title,(1),"[675, 691, 703, 721]",figure_caption_candidate,0.85,"[""figure_title label: (1)""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +4,19,figure_title,(F),"[106, 745, 140, 774]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,20,figure_title,(G),"[425, 749, 464, 778]",figure_inner_text,0.9,"[""panel label / figure inner text: (G)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,21,image,,"[124, 781, 399, 1170]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,22,chart,,"[424, 801, 694, 1167]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,23,image,,"[740, 696, 1020, 932]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,24,chart,,"[739, 942, 1033, 1179]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,25,figure_title,Figure 2. A) In vivo bone regeneration efficacy of whitlockite (WH: Ca $ _{18} $Mg $ _{2} $(HPO $ _{4} $) $ _{2} $(PO $ _{4} $) $ _{12} $) embedded 3D cryogel implants after 6 weeks of subcutaneous in,"[90, 1187, 1094, 1361]",figure_caption,0.92,"[""figure_title label: Figure 2. A) In vivo bone regeneration efficacy of whitlocki""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +4,26,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,27,number,2301283 (4 of 27),"[524, 1484, 658, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,28,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,29,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header,small methods,"[1003, 36, 1095, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +5,2,header,www.small-methods.com,"[902, 97, 1096, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,3,text,"purity, while this method also has some disadvantages such as requiring the use of organic solvents, long preparation time, and difficulty in controlling crystal structure. These methods are only part","[95, 149, 587, 281]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"However, $ \beta $-TCP scaffolds are brittle and are often mixed with other biomaterials to counteract the drawback of low tensile strength. The use of porous $ \beta $-TCP scaffolds in bone regener","[95, 281, 587, 501]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,paragraph_title,2.1.3. Biphasic Calcium Phosphate,"[98, 543, 351, 566]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.3. Biphasic Calcium Phosphate""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,6,text,"BCP is a combination of HAP and $ \beta $-TCP, and, as a result, combines the advantages of two calcium phosphates, including the good biocompatibility, osteoconductivity, and osteoinductivity of bot","[95, 587, 588, 917]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,"Nevertheless, BCP has low biological activity, which is not conducive to the proliferation and differentiation of bone cells. In addition, the slow degradation rate of BCP may affect the regeneration ","[96, 918, 587, 1203]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,paragraph_title,2.1.4. Phosphate Bioactive Glasses,"[97, 1246, 349, 1268]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1.4. Phosphate Bioactive Glasses""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,9,text,"Different BGs can be fabricated by varying the ratios of calcium oxide, silicate, borate, and phosphorus, and several BGs have been used for bone regeneration. BGs can release bioactive ions that prom","[95, 1288, 588, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"tion by releasing proangiogenic ions.[41] For example, strontium- +doped BG nanoparticles could enhance osteoblast activity and +induce osteoblasts to generate cytokines associated with vascu- +larizatio","[604, 149, 1097, 302]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,"Mesoporous BGs doped with manganese and silver have been proposed to exhibit antibacterial activity and facilitate wound healing by preventing infection. $ ^{[49,50]} $ Nanostructured BGs with highly ","[605, 303, 1098, 632]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,text,"Among various preparation methods, sol-gel method is a common one, which involves preparing sol, gel, drying, and heat treatment. BGs has good biocompatibility and biodegradability, which can promote ","[605, 633, 1098, 1004]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,text,"In recent years, ceramics has been utilized in various forms, such as coating and scaffold, for bone regeneration due to its unique bioactive properties and effectiveness in promoting bone regeneratio","[604, 1004, 1099, 1313]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,14,paragraph_title,2.2. Polymers,"[607, 1355, 717, 1378]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Polymers""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,15,text,"Polymers are easy to manufacture and can be obtained in desirable sizes and shapes. Based on their source, they are","[605, 1398, 1099, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,16,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,17,footer,2301283 (5 of 27),"[530, 1484, 665, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,18,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,19,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/snmd.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153, 29, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 45, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header_image,,"[997, 36, 1089, 98]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +6,2,header,www.small-methods.com,"[897, 98, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,figure_title,Table 1. Summarization of ceramics: advantages and disadvantages.,"[91, 149, 549, 170]",table_caption,0.9,"[""table prefix matched: Table 1. Summarization of ceramics: advantages and disadvant""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,4,table,"
Type of ceramicsAdvantagesDisadvantagesReferences
HAPResembles mineral phase of bonePoor mechanical properties<","[90, 184, 1086, 558]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,5,text,"classified as natural or synthetic polymers. Natural polymers such as polysaccharides (chitosan, hyaluronic acid, cellulose, alginate, starch, carrageenan, and gellan gum) and proteins (collagen, gela","[89, 609, 582, 1073]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,paragraph_title,2.2.1. Natural Polymers,"[92, 1114, 269, 1136]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.1. Natural Polymers""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,7,text,Chitosan is made up of glucosamine and N-acetyl glucosamine units that are linked together by $ \beta(1-4) $ glycosidic bonds. Chitosan is a versatile natural polymer derived from the partial deacety,"[89, 1157, 583, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,"with high stem cell affinity could promote cell proliferation, ad- +hesion, and osteogenesis in vitro and upregulate the expression +of osteogenic markers and alkaline phosphatase (ALP) activity.[57] +Poly","[598, 609, 1093, 982]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"Alginate is a linear polysaccharide that contains β-D-mannuronate (M) and α-L-guluronate (G) residues, which are linked together in a (1, 4) configuration. Alginate extracted from brown seaweed posses","[598, 982, 1093, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,11,number,2301283 (6 of 27),"[525, 1484, 658, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,12,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,13,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +7,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header,small methods,"[1003, 37, 1095, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +7,2,header,www.small-methods.com,"[902, 97, 1096, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,3,text,deliver bone-forming peptide-1. $ ^{[63]} $ A thermo-sensitive alginate/ $ \beta $-TCP/aspirin hydrogel with an interconnected porous microstructure fabricated by Fang et al. was implanted into the pe,"[95, 149, 588, 633]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"Hyaluronic acid (HA) is an important component of the ECM in the human body, and its interaction with cluster of differentiation 44 (CD44) may regulate cell motility and adhesion. $ ^{[65]} $ Bioactiv","[96, 633, 587, 1268]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"Collagen is the most abundant protein in bone ECM, and type I collagen is the most ubiquitous among $ \approx $29 types of collagen, especially in bone tissues. $ ^{[70]} $ Collagen is a fibrous prot","[95, 1266, 588, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"cific mechanical and biological properties. Collagen can be ap- +plied to bone tissue engineering in different physical forms, such +as scaffolds, hydrogels, sponges, films, micro-and nanospheres, +and compo","[604, 148, 1099, 742]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"Gelatin is derived from the degradation of type I collagen. Gelatin has biologically functional arginine–glycine–aspartate-binding sequences that improve cell adhesion, differentiation, and proliferat","[604, 742, 1098, 1311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,Silk fibroin is a sustainable and biocompatible fibrous polymer with high mechanical strength that is suitable for use as a bone biomaterial. The degradation rate of silk fibroin-based biomaterials ca,"[604, 1310, 1098, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,10,footer,2301283 (7 of 27),"[530, 1484, 665, 1508]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,11,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,12,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smld.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 31, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +8,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header_image,,"[997, 37, 1089, 97]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +8,2,header,www.small-methods.com,"[897, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"osteogenesis of silk fibroin limits its application in bone repair, it can promote new bone formation when combined with other biomaterials. For instance, a silk fibroin/chitosan/HAP composite combine","[90, 149, 582, 678]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,2.2.2. Synthetic Polymers,"[92, 720, 279, 743]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.2. Synthetic Polymers""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,5,text,"Polycaprolactone (PCL), polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers are US Food and Drug Administration (FDA) approved polyesters that are extensively used in bone repair and ","[90, 763, 581, 895]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"PLA is characterized by cytocompatibility, non-toxic degradation products, and thermal stability. $ ^{[82,83]} $ Grémare et al. reported that the cell viability and metabolic activity of human bone ma","[89, 895, 582, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,text,"biodegradation rate and mechanical properties by changing its +structure and morphology, such as its molecular weight and +cross-linking.","[600, 149, 1091, 214]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"PGA has a high tensile modulus and porosity and can be easily manipulated and manufactured into various shapes. $ ^{[88]} $ However, its rapid degradation rate, low mechanical strength, and acidic deg","[598, 213, 1093, 1049]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,text,"PCL is an aliphatic polymer, consisting of hexanoate units, and has high crystallinity, easily manipulable mechanical characteristics, and good biocompatibility. Lin et al. reported that the PCL/cobal","[598, 1049, 1093, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,11,number,2301283 (8 of 27),"[524, 1484, 658, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,12,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,13,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 30, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,"small methods +www.small-methods.com","[901, 36, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,2,figure_title,(A),"[103, 155, 137, 181]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,3,image,,"[149, 158, 346, 306]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,4,image,,"[340, 157, 575, 315]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,5,image,,"[569, 155, 834, 328]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,image,,"[846, 157, 1080, 351]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,7,image,,"[142, 329, 826, 586]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,8,figure_title,(B),"[850, 155, 881, 180]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,figure_title,(C),"[848, 355, 879, 380]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,10,chart,,"[847, 365, 1093, 577]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,11,figure_title,(D),"[109, 596, 140, 621]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,12,image,,"[128, 602, 475, 849]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,13,figure_title,(F),"[491, 607, 522, 628]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,14,image,,"[483, 601, 838, 766]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,15,figure_title,(G),"[820, 599, 855, 623]",figure_inner_text,0.9,"[""panel label / figure inner text: (G)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,16,chart,,"[824, 601, 1085, 775]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,17,figure_title,(H),"[479, 762, 511, 785]",figure_inner_text,0.9,"[""panel label / figure inner text: (H)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,18,figure_title,(E),"[117, 855, 147, 879]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,19,image,,"[479, 763, 820, 877]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,20,figure_title,(K),"[839, 772, 873, 795]",figure_inner_text,0.9,"[""panel label / figure inner text: (K)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,21,image,,"[126, 859, 467, 1016]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,22,image,,"[836, 773, 1089, 861]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,23,chart,,"[484, 884, 635, 1017]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,24,chart,,"[633, 885, 824, 1017]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,25,image,,"[822, 866, 1090, 1016]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,26,figure_title,"Figure 3. A) Biomimetic melt electrowritten lattice and bioglass particle reinforced hydrogel scaffolds were fabricated. B) The weight percents of Ca, P, and Ca/P ratio for all the scaffolds. C) FTIR ","[94, 1025, 1101, 1160]",figure_caption,0.92,"[""figure_title label: Figure 3. A) Biomimetic melt electrowritten lattice and biog""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +9,27,text,"degradation rate and poor hydrophilicity restrict its application in bone tissue engineering. To overcome these shortcomings, PCL can be compounded with other materials, doped and modified. Among them","[95, 1200, 588, 1443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,28,text,"Different kinds of polymeric scaffolds have increasingly been +employed in bone repair and regeneration for the past few years. +Polymeric scaffolds combined with growth factors and stem cells +can modulate","[604, 1199, 1099, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,29,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,30,number,2301283 (9 of 27),"[530, 1484, 664, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,31,footer,© 2024 Wiley-VCH GmbH,"[937, 1486, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,32,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smll.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1155, 32, 1171, 1536]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +10,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[91, 45, 338, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header_image,,"[896, 36, 1092, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +10,2,figure_title,Table 2. Summarization of polymers: advantages and disadvantages.,"[91, 149, 551, 171]",table_caption,0.9,"[""table prefix matched: Table 2. Summarization of polymers: advantages and disadvant""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,3,table,"
Type of polymersExamplesAdvantagesDisadvantagesReferences
Natural polymersChitosanResistance to bacter","[91, 182, 1085, 1037]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +10,4,text,"current limitations of polymeric scaffolds in bone repair and regeneration include the possible retention of toxic products resulting from polymer degradation, denaturation of biomolecules bound to th","[90, 1091, 582, 1270]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,paragraph_title,2.3. Metals,"[91, 1307, 182, 1328]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Metals""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,6,text,"Metals with excellent mechanical properties and load-bearing capacities are ideal for bone implantation and cardiovascular stents. Commonly used metallic materials, such as titanium, magnesium, iron, ","[90, 1350, 582, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,text,"production and processing, mild stretchability, low modulus, +good cytocompatibility, and corrosion resistance.[98] Titanium +and its alloys are the most commonly used metallic materials for +bone-defect","[599, 1091, 1093, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,9,footer,2301283 (10 of 27),"[520, 1484, 663, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,10,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,11,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/snml.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153, 29, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +11,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header,small methods,"[1003, 36, 1095, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +11,2,header,www.small-methods.com,"[902, 97, 1096, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,3,text,"ions released by metal degradation, such as magnesium, iron, zinc, and strontium, have important effects on bone healing by affecting the balance between bone cells and are regarded as biological fact","[95, 149, 588, 610]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,Metal-organic frameworks (MOFs) with intramolecular pores and intrinsic bioactivity comprise metal ions and organic ligands. The large specific surface area of MOFs is conducive to cell adhesion and p,"[95, 610, 588, 1226]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"There are several methods for preparing MOFs, including solvothermal synthesis (mixing metal ions and organic ligands in an organic solvent, heating to a certain temperature, and forming crystals), hy","[95, 1223, 588, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,"ing metal ions and organic ligands in water and organic solvents, +heating to a certain temperature, and forming crystals). Each of +these methods has its own advantages and disadvantages, and the +speci","[605, 149, 1099, 503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,paragraph_title,2.4. Layered Double Hydroxide,"[607, 565, 844, 588]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Layered Double Hydroxide""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +11,8,text,"Several studies have focused on the application of layered double hydroxide (LDH) in the biomedical field, such as drug/gene delivery, bone repair and regeneration, and biological functional surface m","[604, 609, 1098, 1094]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"Multifunctional layered SrFe₁₂O₁₉-LDH/chitosan scaffolds composed of SrFe₁₂O₁₉ nanoparticles, LDH nanoparticles, and bioactive chitosan can inhibit bone resorption in osteoclasts and the release of pr","[605, 1091, 1098, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,11,footer,2301283 (11 of 27),"[526, 1483, 669, 1508]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,12,footer,© 2024 Wiley-VCH GmbH,"[937, 1486, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,13,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +12,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[91, 45, 340, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header_image,,"[894, 36, 1092, 117]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +12,2,figure_title,(A),"[102, 162, 145, 193]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,3,image,,"[155, 147, 1087, 407]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,4,figure_title,(B),"[103, 408, 143, 439]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,5,image,,"[122, 419, 1071, 617]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,6,figure_title,(C),"[99, 609, 139, 642]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,7,image,,"[138, 631, 1071, 802]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,8,figure_title,(D),"[107, 820, 150, 851]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,9,image,,"[108, 823, 966, 901]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,10,figure_title,(E),"[761, 911, 802, 941]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,11,image,,"[157, 923, 725, 1177]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,12,image,,"[830, 918, 1028, 1103]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,13,image,,"[160, 1209, 445, 1394]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,14,figure_title,(F),"[754, 1119, 794, 1151]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,15,image,,"[458, 1181, 729, 1409]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,16,image,,"[804, 1121, 1040, 1265]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,17,image,,"[803, 1276, 1041, 1420]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,18,footer,"Small Methods 2024, 8, 2301283","[94, 1486, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,19,footer,2301283 (12 of 27),"[521, 1484, 663, 1508]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,20,footer,© 2024 Wiley-VCH GmbH,"[931, 1486, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,21,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 30, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +13,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,header,small methods,"[1003, 36, 1096, 95]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +13,2,header,www.small-methods.com,"[902, 98, 1096, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,3,text,"osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities (Figure 5I–L). $ ^{[123]} $","[95, 149, 586, 192]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"The preparation method of LDH has a great influence on its properties. For example, different preparation methods can obtain different layered structures, which can affect its physical and chemical pr","[96, 193, 588, 260]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,text,"chemical properties. Common preparation methods include co- +precipitation, hydrothermal synthesis, ion exchange, etc. In ad- +dition, the preparation method of LDH can also affect its crystal +structure,","[605, 149, 1098, 260]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,6,text,"Figure 4. A) Scheme showing MgGA MOF and PLGA/Mg-GA MOF scaffold preparation. B) ALP staining of hBMSCs in the extracts. C) ARS staining of hBMSCs in the extracts. $ ^{[112]} $ Copyright 2022, Elsevie","[96, 319, 1099, 417]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 4. 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A) ALP staining and ARS staining of Control, Let-7d, LDH and LDH/let-7d groups on day 7 and day 14, respectively. Scale bars: 500 $ \mu $m. B) LDH/let-7d-incorporated fibrin scaffolds promo","[95, 1254, 1100, 1428]",figure_caption,0.92,"[""figure_title label: Figure 5. A) ALP staining and ARS staining of Control, Let-7""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +13,40,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,41,number,2301283 (13 of 27),"[526, 1484, 669, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,42,footer,© 2024 Wiley-VCH GmbH,"[937, 1486, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,43,aside_text,"23669608, 2024, 8. Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1147, 34, 1171, 1471]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +14,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 45, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,1,header,small methods,"[997, 36, 1089, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +14,2,header,www.small-methods.com,"[896, 96, 1090, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,3,paragraph_title,2.5. Composites,"[91, 148, 219, 171]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Composites""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,4,text,"As mentioned above, each material has merits and shortcomings in bone tissue engineering. The main limitations of individual materials are the brittleness and low degradability of ceramics, weak mecha","[89, 192, 581, 391]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,text,"Composite scaffolds have been used to regulate scaffold properties and repair bone defects. Numerous studies have applied ceramic and polymer composites in bone tissue engineering. For example, a chit","[89, 392, 583, 1245]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,"The preparation method affects the mechanical properties, thermal conductivity, heat resistance, and corrosion resistance of composite materials. For example, different preparation methods can control","[89, 1244, 583, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,text,"als. In summary, the preparation method of composite materials +has an important influence on their properties. Through the de- +velopment of new technical systems, the innovation and develop- +ment of bi","[600, 149, 1093, 326]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,8,paragraph_title,3. 3D printing Scaffolds and External Stimuli-Responsive Biomaterials for Bone Therapeutics and Regeneration,"[601, 360, 1003, 435]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3. 3D printing Scaffolds and External Stimuli-Responsive Bio""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +14,9,text,"Through the development of new technical systems, the innovation and development of biological materials can be promoted, and their performance and effect can be improved. The new technology system ca","[599, 447, 1093, 801]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,10,paragraph_title,3.1. 3D Printing Technology for Bone Tissue Engineering,"[601, 835, 1029, 859]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1. 3D Printing Technology for Bone Tissue Engineering""]",subsection_heading,0.6,body_zone,body_like,none,True,True +14,11,text,Developing 3D printing scaffolds have been used successfully to repair bone defects while effectively accelerating bone regeneration. Composite 3D printing scaffolds possess favorable characteristics ,"[600, 879, 1093, 1165]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,12,paragraph_title,3.1.1. Advances in 3D Printing Technology,"[602, 1202, 908, 1225]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1.1. Advances in 3D Printing Technology""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,13,text,"A large variety of conventional techniques, such as gas foaming, freeze-drying, solvent casting, phase separation, and electrospinning, have been used to manufacture scaffolds for various tissues base","[598, 1245, 1093, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,14,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,15,footer,2301283 (14 of 27),"[520, 1484, 663, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +14,16,footer,© 2024 Wiley-VCH GmbH,"[931, 1486, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,17,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +15,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,header,"small methods +www.small-methods.com","[900, 36, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,2,figure_title,(A),"[109, 152, 144, 180]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,3,image,,"[109, 162, 583, 282]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,4,figure_title,(B),"[109, 278, 142, 306]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,5,chart,,"[433, 168, 580, 283]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,6,image,,"[152, 286, 275, 400]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,7,chart,,"[431, 292, 580, 403]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,8,figure_title,(a),"[634, 181, 658, 202]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,9,figure_title,(D),"[594, 152, 628, 179]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,10,figure_title,(C),"[108, 400, 143, 428]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,11,chart,,"[161, 416, 362, 561]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,12,chart,,"[381, 420, 577, 561]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,13,image,,"[603, 155, 1084, 524]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,14,chart,,"[164, 570, 362, 716]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,15,chart,,"[381, 571, 580, 715]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,16,image,,"[610, 565, 762, 685]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,17,image,,"[765, 567, 928, 680]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,18,image,,"[933, 567, 1087, 678]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,19,figure_title,(E),"[104, 725, 139, 754]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,20,figure_title,(G),"[475, 726, 510, 753]",figure_inner_text,0.9,"[""panel label / figure inner text: (G)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,21,image,,"[135, 750, 454, 912]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,22,figure_title,(F),"[105, 911, 136, 940]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,23,image,,"[130, 915, 459, 1078]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,24,image,,"[486, 732, 1084, 1086]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,25,figure_title,"Figure 6. A,B) SEM image of scaffolds after soaking in SBF for 5 days (A1, A2: MBG/SF scaffold; B1, B2: MBG/PCL scaffold) and EDS spectra (A3: MBG/SF scaffold; B3:MBG/PCL scaffold). C) The relative ex","[95, 1098, 1100, 1252]",figure_caption,0.92,"[""figure_title label: Figure 6. A,B) SEM image of scaffolds after soaking in SBF f""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +15,26,text,"mesoporous bioactive glass (MBG) to fabricate MBG/SF composite scaffolds by 3D printing, and the results revealed that the gene expression levels of common osteogenic biomarkers on MBG/SF scaffolds we","[95, 1288, 587, 1399]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,27,text,3D printing combined with 3D computer imaging and calculation software can be used to fabricate tailored implants with complex 3D structures for patients with bone tissue defects. $ ^{[135]} $ Precise,"[96, 1399, 588, 1443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,28,text,"plex 3D structures for patients with bone tissue defects.[135] Pre- +cise control of the bulk geometry and internal structure of scaf- +folds is a major advantage of 3D printing technology in bone engi-","[604, 1288, 1099, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,29,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,30,number,2301283 (15 of 27),"[526, 1483, 668, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +15,31,footer,© 2024 Wiley-VCH GmbH,"[937, 1486, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,32,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +16,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,1,header_image,,"[997, 36, 1089, 97]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +16,2,header,www.small-methods.com,"[897, 98, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,3,text,"architecture of native bone. $ ^{[136]} $ In addition, several 3D bioprinting techniques, such as inkjet, extrusion, and laser-assisted bioprinting, have been developed in regenerative medicine, which","[90, 149, 582, 436]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,4,paragraph_title,3.1.2. The Basic Requirements of Bone Scaffolds,"[91, 479, 439, 502]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1.2. The Basic Requirements of Bone Scaffolds""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +16,5,text,"The mechanical integrity, microstructure, biocompatibility, biodegradability, and osteoconductivity are crucial properties of scaffolds for bone repair and regeneration, and it is essential to achieve","[90, 521, 582, 1115]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,text,"Postprint modification is often applied to improve the performance of bone scaffolds and obtain the desired effect. Such modifications can promote stem cell proliferation and differentiation, and impr","[89, 1114, 583, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,7,text,"10–50 μm, were used as the initial printing materials in the print- +ing ink formulations (Figure 6D).[32]","[601, 148, 1091, 195]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,8,paragraph_title,3.1.3. 3D-Printed Scaffolds for Bone Repair,"[602, 238, 913, 260]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1.3. 3D-Printed Scaffolds for Bone Repair""]",subsection_heading,0.6,body_zone,body_like,none,True,True +16,9,text,"Composites can combine the merits of two or more different types of materials and thus meet the performance requirements of bone scaffolds to a large extent, including mechanical and biological proper","[598, 281, 1093, 1158]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,10,text,"In recent years, increasing researchers have applied 3D printing technology to bone tissue regeneration. Polymer materials and hydrogel materials have their own advantages and disadvantages in bone re","[598, 1158, 1093, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,11,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,12,footer,2301283 (16 of 27),"[520, 1484, 663, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +16,13,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,14,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/snmd.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153, 29, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +17,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 44, 345, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,1,header,"small methods +www.small-methods.com","[901, 36, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,2,figure_title,Table 3. Summarization of physical stimuli-responsive strategies: advantages and disadvantages.,"[97, 149, 743, 171]",table_caption,0.9,"[""table prefix matched: Table 3. Summarization of physical stimuli-responsive strate""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +17,3,table,
Type of physical stimuli-responsive strategiesAdvantagesDisadvantagesReferences.
Photoresponsive strategyNoninvasive with high contr,"[97, 183, 1092, 577]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +17,4,text,"preparation of high-quality tantalum implants, and exploration of breakthrough directions in bone tissue engineering printing technology.","[95, 631, 587, 698]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,5,paragraph_title,3.2. Physical Stimuli-Responsive Bone Therapy and Regeneration,"[96, 730, 585, 753]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Physical Stimuli-Responsive Bone Therapy and Regenerati""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +17,6,text,"Numerous strategies have been developed to manufacture physical stimuli-responsive materials for bone-tissue engineering. External physical stimuli, including light, magnetic and electric fields, ultr","[95, 773, 588, 996]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,paragraph_title,3.2.1. Photoresponsive Strategy,"[98, 1027, 326, 1049]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.1. Photoresponsive Strategy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +17,8,text,"Photoresponsive materials can be activated by externally applied optical signals and generate photophysical effects, subsequently affecting intracellular behavior and the respiratory chain, facilitati","[96, 1071, 588, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,9,text,"Sr2+ by flawing the PLGA shells, ultimately promoting bone re- +generation in rat femoral defect models.[148] Under 808-nm near- +infrared light irradiation, HAP/graphene oxide/chitosan scaf- +folds with ","[605, 630, 1098, 876]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,10,paragraph_title,3.2.2. Electroresponsive Strategy,"[609, 917, 842, 940]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.2. Electroresponsive Strategy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +17,11,text,Previous studies have shown that electrical stimuli can enhance bone regeneration and maintain the stemness of bone marrow MSCs. The mechanism of this effect is related to the stimulation of MSC proli,"[605, 961, 1099, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,12,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,13,number,2301283 (17 of 27),"[526, 1484, 669, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +17,14,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,15,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +18,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +18,1,header,small methods,"[997, 36, 1089, 96]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +18,2,header,www.small-methods.com,"[897, 97, 1090, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +18,3,text,"was applied, titanium sheets coated with polyaniline (poly(amide-amine) dendrimer) @ Ag layer exhibited excellent antibacterial properties and improved osteogenic differentiation compared with pure ti","[90, 148, 581, 436]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,4,paragraph_title,3.2.3. Magnetic-Responsive Strategy,"[92, 478, 354, 501]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.3. Magnetic-Responsive Strategy""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +18,5,text,Magnetic-responsive materials are composed of ferromagnetic or paramagnetic nanoparticles that can be manipulated by magnetic fields and act as therapeutic agents for magnetic hyperthermia. Magnetic n,"[89, 519, 583, 1315]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,6,paragraph_title,3.2.4. Ultrasound-Responsive Strategy,"[92, 1355, 367, 1379]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.4. Ultrasound-Responsive Strategy""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +18,7,text,"Ultrasound has been shown to promote bone regeneration by increasing the mRNA expression of VEGF-A and stimulating the proliferation of chondrocytes, thereby facilitating the formation of new bone and","[90, 1398, 582, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,8,text,"the proliferation of chondrocytes, thereby facilitating the for- +mation of new bone and cell mineralization (Figure 7A–C).[158] +Nanocomplexes can be triggered by nonthermal clinical diag- +nostic ultra","[600, 149, 1093, 545]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,9,paragraph_title,3.2.5. Piezoelectricity-Responsive Strategy,"[602, 588, 902, 611]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.5. Piezoelectricity-Responsive Strategy""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +18,10,text,Natural bone tissues exhibit bioelectrical properties that are essential for bone development. Piezoelectricity is the conversion of mechanical energy into electrical energy. Under physiological condi,"[598, 632, 1094, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,11,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,12,footer,2301283 (18 of 27),"[520, 1484, 663, 1507]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +18,13,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,14,aside_text,"23669608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkl.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1153, 22, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,body_like,none,False,False +19,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 44, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +19,1,header_image,,"[900, 35, 1097, 117]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +19,2,image,,"[103, 150, 1085, 821]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +19,3,figure_title,"Figure 7. A,B) Water contact angle measurement for the Ti6Al4V substrate (A1) and Ti6Al4V substrate with BaTiO₃ coating (B1); Surface CLSM images of the Ti6Al4V substrate (A2) and Ti6Al4V substrate wi","[95, 836, 1100, 954]",figure_caption,0.92,"[""figure_title label: Figure 7. A,B) Water contact angle measurement for the Ti6Al""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +19,4,text,Piezo1 by fabricating a wearable pulsed triboelectric nanogenerator (WP-TENG) driven by human body movement (Figure 7D). $ ^{[16]} $ Epigallocatechin gallate (EGCG) was loaded into gold nanoparticle-m,"[95, 981, 587, 1113]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,5,text,"Physical stimuli-responsive strategies lack controllability, predictability, feasibility, and standardization in bone repair and regeneration applications according to existing research. These materia","[95, 1113, 589, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,6,text,"cross-fusion is also an inevitable trend in the clinical develop- +ment of orthopedics. Therefore, future research will focus on +developing better materials to promote bone tissue regeneration +and func","[604, 981, 1099, 1071]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,7,paragraph_title,4. The Underlying Mechanism of Bioactive Materials for Bone Regeneration,"[606, 1115, 1017, 1166]",section_heading,0.85,"[""paragraph_title label with numbering: 4. The Underlying Mechanism of Bioactive Materials for Bone ""]",section_heading,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +19,8,text,Understanding the molecular mechanism of bioactive materials on bone tissue can improve the design and preparation of materials to better promote bone regeneration. By studying the molecular mechanism,"[605, 1179, 1099, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,9,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,10,number,2301283 (19 of 27),"[526, 1484, 669, 1508]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +19,11,footer,© 2024 Wiley-VCH GmbH,"[937, 1486, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,12,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,body_like,none,False,False +20,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[93, 45, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +20,1,header,small methods,"[997, 36, 1089, 96]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,2,header,www.small-methods.com,"[897, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +20,3,paragraph_title,4.1. Regulation of Stem Cells by Biomaterials,"[91, 149, 432, 171]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.1. Regulation of Stem Cells by Biomaterials""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,4,text,Stem cells are undifferentiated cells that self-renew and produce an abundance of undifferentiated offspring. They have strong proliferative capacity and multi-lineage differentiation ability; therefo,"[90, 192, 582, 565]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,5,text,"Bone biomaterials act as platforms to facilitate stem cell adhesion and growth during bone repair. The chemical components, surface characteristics, and topographic structure of bone biomaterials dire","[90, 566, 582, 1073]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,6,paragraph_title,4.2. Biomaterial-Induced Pathway Modulation for Bone Regeneration,"[91, 1102, 506, 1148]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2. Biomaterial-Induced Pathway Modulation for Bone Regener""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,7,text,"Several signaling pathways and transcription factors have been shown to regulate the osteogenic differentiation of stem cells. To develop novel strategies for bone repair and regeneration, it is neces","[90, 1168, 581, 1302]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,8,paragraph_title,4.2.1. BMP Signaling Pathway,"[92, 1334, 317, 1357]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.1. BMP Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,9,text,BMPs belong to the TGF- $ \beta $ superfamily and are of great importance in bone formation and tissue homeostasis. This signaling is initiated by the binding of BMP to BMP receptors on the cell membr,"[90, 1376, 582, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,10,text,"the cell membrane, and the downstream Smad proteins are then +phosphorylated by activated receptors. Smad complexes translo- +cate into the nucleus, activating osteogenesis-related transcrip- +tion facto","[600, 150, 1093, 700]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,11,paragraph_title,4.2.2. Wnt Signaling Pathway,"[603, 720, 821, 743]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.2. Wnt Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,12,text,The Wnt/ $ \beta $-catenin signaling pathway is recognized as a crucial signal for the regulation of stem cell osteogenic differentiation and is strongly associated with the formation and regeneration,"[600, 762, 1093, 1336]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,13,paragraph_title,4.2.3. Notch Signaling Pathway,"[602, 1355, 836, 1379]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.3. Notch Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +20,14,text,"Notch signaling is a highly persistent pathway associated with cell signal transduction, self-renewal potential and proliferation,","[600, 1398, 1092, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,15,footer,"Small Methods 2024, 8, 2301283","[94, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,16,footer,2301283 (20 of 27),"[520, 1484, 663, 1507]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +20,17,footer,© 2024 Wiley-VCH GmbH,"[932, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,18,aside_text,"2369608, 2024, 8, Downloaded from https://ontinelibrary.wiley.com/doi/10.1002/smid.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:/","[1154, 29, 1172, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +21,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 346, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +21,1,header,"small methods +www.small-methods.com","[901, 36, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +21,2,figure_title,(A),"[105, 163, 133, 187]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,3,image,,"[106, 156, 654, 485]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,4,figure_title,(C),"[106, 500, 135, 524]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,5,image,,"[671, 160, 1088, 478]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,6,chart,,"[279, 515, 419, 651]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,7,chart,,"[419, 514, 576, 650]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,8,figure_title,(D),"[559, 493, 587, 515]",figure_inner_text,0.9,"[""panel label / figure inner text: (D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,9,chart,,"[127, 655, 273, 796]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,10,chart,,"[273, 658, 419, 793]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,11,chart,,"[420, 658, 563, 793]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +21,12,image,,"[594, 499, 1079, 834]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,13,figure_title,(E),"[105, 819, 133, 842]",figure_inner_text,0.9,"[""panel label / figure inner text: (E)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,14,image,,"[112, 818, 587, 1200]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,15,figure_title,(F),"[588, 852, 614, 875]",figure_inner_text,0.9,"[""panel label / figure inner text: (F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +21,16,image,,"[630, 859, 1043, 1192]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +21,17,figure_title,Figure 8. A) Schematic illustration of the procedure to fabricate BP@BMP2 electrospun fibrous scaffolds and the effect of recruiting osteoblasts and releasing calcium-free phosphate therapy for promot,"[96, 1216, 1100, 1353]",figure_caption,0.92,"[""figure_title label: Figure 8. A) Schematic illustration of the procedure to fabr""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +21,18,footer,"Small Methods 2024, 8, 2301283","[99, 1487, 289, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,19,number,2301283 (21 of 27),"[526, 1484, 668, 1508]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +21,20,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,21,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smld.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 31, 1172, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +22,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +22,1,header_image,,"[997, 36, 1089, 97]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +22,2,header,www.small-methods.com,"[897, 97, 1090, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +22,3,text,"and skeletal development. Upon cell-cell contact, Notch ligands (Jagged and Delta) interact with Notch receptors (Notch1–4), leading to the cleavage of the Notch intracellular domain. Subsequently, th","[89, 148, 583, 701]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,4,paragraph_title,4.2.4. MAPK Signaling Pathway,"[92, 742, 327, 765]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.4. MAPK Signaling Pathway""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +22,5,text,"The mitogen-activated protein kinase (MAPK) family comprises extracellular regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), which are associated with signal transduction in osteoblasts.","[89, 784, 582, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,6,paragraph_title,4.2.5. Other Osteogenesis-Relevant Signaling Pathways,"[602, 148, 1001, 172]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2.5. Other Osteogenesis-Relevant Signaling Pathways""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +22,7,text,"In addition to the aforementioned pathways, bone development and homeostasis involve several other pathways that play an indispensable role in the osteogenic differentiation of undifferentiated and os","[599, 192, 1093, 524]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,8,paragraph_title,5. Conclusions and Outlook,"[602, 548, 873, 574]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions and Outlook""]",section_heading,0.85,,heading_like,heading_numbered,True,True +22,9,text,"Herein, we summarized several biomaterials with unique biofunctions, bioactive compounds, 3D bioprinting techniques, and physical stimuli-responsive strategies for bone repair and regeneration. Among ","[600, 588, 1093, 961]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,10,text,"3D printing technology is a novel strategy in precision medicine that can produce bone implants using multiple materials based on digital models. With advances in 3D printing technology, novel composi","[598, 961, 1094, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +22,11,footer,"Small Methods 2024, 8, 2301283","[93, 1487, 283, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +22,12,footer,2301283 (22 of 27),"[520, 1484, 663, 1507]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +22,13,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +22,14,aside_text,"23699608, 2024, 8, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smkt.202301283 by Shandong University Library, Wiley Online Library on [18/02/2026]. See the Terms and Conditions (https:","[1154, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,body_like,none,False,False +23,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +23,1,header_image,,"[1003, 36, 1095, 95]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +23,2,header,www.small-methods.com,"[903, 98, 1096, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +23,3,text,"osteogenic substances to stimulate cell growth and differentiation, ultimately improving bone regeneration. These advanced strategies will play crucial roles in precise and efficient bone-tissue repai","[96, 149, 587, 236]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,4,text,"Despite the promising results presented herein, the literature primarily focuses on the development of scaffolds using advanced biomaterials, but lacks sufficient researches on the use of biomaterial-","[96, 237, 587, 479]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,5,paragraph_title,Acknowledgements,"[97, 524, 289, 549]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +23,6,text,"Y.B. and Z.W. contributed equally to this work. This work was financially supported by the National Science Fund for Distinguished Young Scholars (grant no. 82225027), the National Key Research and De","[97, 560, 587, 715]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,7,paragraph_title,Conflict of Interest,"[97, 759, 281, 784]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +23,8,text,The authors declare no conflict of interest.,"[97, 797, 382, 817]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +23,9,paragraph_title,Keywords,"[98, 863, 196, 888]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Keywords""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +23,10,text,"advanced techniques, bioactive materials, bone regeneration, molecular mechanism, stem cells","[97, 900, 586, 940]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,11,text,"Received: September 22, 2023 +Revised: November 4, 2023 +Published online: March 21, 2024","[360, 963, 586, 1020]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +23,12,reference_content,"[1] V. 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Kabra, S. Varghese, Front. Bioeng. Biotechnol. 2015, 3, 185.","[610, 1267, 1096, 1305]",reference_item,0.85,"[""reference content label: [167] V. Rao, Yu-Ru V. Shih, H. Kang, H. Kabra, S. Varghese,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +25,63,reference_content,"[168] Y. Kang, A. I. Georgiou, R. J. Macfarlane, M. E. Klontzas, M. Heliotis, E. Tsiridis, A. Mantalaris, J. Tissue Eng. Regener. Med. 2017, 11, 1929.","[611, 1308, 1096, 1363]",reference_item,0.85,"[""reference content label: [168] Y. Kang, A. I. Georgiou, R. J. Macfarlane, M. E. Klont""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +25,64,reference_content,"[169] X. Lou, Stem cell Rev. Rep. 2015, 11, 645.","[611, 1367, 922, 1385]",reference_item,0.85,"[""reference content label: [169] X. Lou, Stem cell Rev. 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See the Terms and Conditions (https://","[1155, 33, 1171, 1536]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +26,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.co","[92, 46, 317, 114]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +26,1,header_image,,"[998, 36, 1089, 96]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +26,2,header,www.small-methods.com,"[897, 99, 1089, 115]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +26,3,reference_content,"[171] K. Rutledge, Q. Cheng, M. Pryzhkova, G. M. Harris, E. Jabbarzadeh, Tissue Eng. Part C, Methods 2014, 20, 865.","[93, 151, 578, 189]",reference_item,0.85,"[""reference content label: [171] K. Rutledge, Q. Cheng, M. Pryzhkova, G. M. Harris, E. 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Eng. 2017, 3, 1062.","[605, 151, 1088, 189]",reference_item,0.85,"[""reference content label: [179] S. Midha, S. Chameettachal, E. Dey, S. Ghosh, ACS Biom""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +26,12,reference_content,"[180] S. Y. Choi, M. S. Song, P. D. Ryu, A. T. Lam, S. W. Joo, S. Y. Lee, Int. J. Nanomed. 2015, 10, 4383.","[606, 191, 1089, 230]",reference_item,0.85,"[""reference content label: [180] S. Y. Choi, M. S. Song, P. D. Ryu, A. T. Lam, S. W. Jo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +26,13,reference_content,"[181] V. Deregowski, E. Gazzerro, L. Priest, S. Rydziel, E. Canalis, J. Biol. Chem. 2006, 281, 6203.","[606, 231, 1088, 269]",reference_item,0.85,"[""reference content label: [181] V. Deregowski, E. Gazzerro, L. Priest, S. Rydziel, E. 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Wang, K. Lin, J. Chang, J. Sun, Biomaterials 2013, 34, 64.","[605, 490, 1036, 509]",reference_item,0.85,"[""reference content label: [187] C. Wang, K. Lin, J. Chang, J. Sun, Biomaterials 2013, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +26,20,reference_content,"[188] C. Liu, Q. Yu, Z. Yuan, Q. Guo, X. Liao, F. Han, T. Feng, G. Liu, R. Zhao, Z. Zhu, H. Mao, C. Zhu, B. Li, Bioact. Mater. 2023, 25, 445.","[606, 511, 1088, 548]",reference_item,0.85,"[""reference content label: [188] C. Liu, Q. Yu, Z. Yuan, Q. Guo, X. Liao, F. Han, T. Fe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +26,21,image,,"[115, 600, 314, 855]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +26,22,vision_footnote,"Yuxin Bai is now a postdoctoral fellow in Professor Rongrong Zhu's group at Tongji University, School of Life Science and Technology. 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See the Terms and Conditions (https://","[1155, 33, 1171, 1536]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +27,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +27,1,header,"small methods +methods.com","[1001, 35, 1096, 115]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +27,2,header,www.small-methods.com,"[903, 97, 1096, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +27,3,image,,"[120, 172, 320, 428]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +27,4,text,Shengguang Chen is a clinical doctor at Gongli Hospital of Shanghai Pudong New Area. He has been engaged in clinical research on endocrine and metabolic diseases. 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854, 1184]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,13,text,二〇二三年五月,"[486, 1256, 703, 1292]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,14,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +2,1,text,学位论文题目:,"[176, 218, 378, 254]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +2,2,text,人工智能辅助决策系统在髋关节置换术的临床应用研究,"[175, 280, 906, 318]",unknown_structural,0.8,"[""page-1 zone title_zone: 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role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +2,8,text,论文答辩日期:2023年06月05日,"[175, 1310, 726, 1346]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +2,9,footer,中国知网 https://www.cnki.net,"[37, 1621, 385, 1650]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +3,0,paragraph_title,目录,"[546, 204, 648, 244]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u76ee\u5f55""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +3,1,content,"前言.....1 +1 资料与方法.....4 +1.1 纳入与排除标准.....4 +1.2 一般资料.....5 +1.3 主要设备.....5 +1.4 数据获取.....5 +1.4.1 影像学数据拍摄.....5 +1.4.2 影像学测量参数.....6 +2 研究方法.....7 +2.1 术前规划方式.....7 +2.1.1 AIHIP 规划.....7 +2","[170, 284, 1020, 1514]",unknown_structural,0.2,"[""unrecognized label 'content'""]",unknown_structural,0.2,,unknown_like,none,False,True +3,2,footer,中国知网 https://www.cnki.net,"[37, 1620, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +4,0,content,"综述 全髋关节置换术前规划方式的研究与进展 ..... 37 +综述参考文献 ..... 45 +附录 Harris 髋关节功能评分(百分制) ..... 49","[178, 147, 1016, 252]",unknown_structural,0.2,"[""unrecognized label 'content'""]",unknown_structural,0.2,,unknown_like,none,False,True +4,1,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +5,0,header,海南医学院硕士学位论文,"[493, 85, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +5,1,paragraph_title,缩略语,"[544, 155, 647, 192]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u7f29\u7565\u8bed""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +5,2,table,
英文缩写英文全称中文全称
THATotal Hip Arthroplasty全髋关节置换术
AIArtificial Intelligence人工智能
CT0.05)。影像学测量结果显示两组术后髋臼假体外展角比较无统计学意义(P>0.05),术后股骨柄-髓腔轴线夹角比较无统计学意义(P>0.05),术后股骨柄-髓腔比差异有统计学意义(P<0.05)。AI组和2D组术前术后双下肢长度比较差异明,"[174, 930, 1017, 1526]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +6,5,number,||,"[587, 1565, 604, 1585]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +6,6,footer,中国知网 https://www.cnki.net,"[37, 1621, 385, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +7,0,header,海南医学院硕士学位论文,"[492, 86, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +7,1,abstract,【结论】:AIHIP 系统可对 THA 手术实现精准规划,与二维数字化模板相比,具有更高的精确性和有效性,可辅助术者在 THA 手术中缩短手术时间,减少术中出血量,促进患者术后髋关节功能恢复。,"[179, 150, 1012, 276]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +7,2,text,关键词:全髋关节置换术;人工智能;术前规划,"[178, 377, 688, 407]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +7,3,number,Ⅲ,"[587, 1566, 604, 1584]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +7,4,footer,中国知网 https://www.cnki.net,"[38, 1622, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +8,1,doc_title,"Clinical application research of artificial intelligence +assisted decision-making system in hip replacement","[187, 216, 1001, 323]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,,unknown_like,none,False,True +8,2,paragraph_title,ABSTRACT,"[516, 465, 676, 504]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,,heading_like,short_fragment,True,True +8,3,abstract,"[Objective]: To compare the preoperative planning with the two-dimensional digital template (TDTD), and investigate the accuracy and effectiveness of Artificial intelligence system (AIS) in the clinic","[174, 584, 1011, 746]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +8,4,abstract,"[Methods]: From June 2020 to December 2022, a prospective study was conducted on 100 patients who needed primary total hip replacement due to hip joint disease, and patients who met the inclusion crit","[174, 761, 1011, 1173]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +8,5,abstract,"[Results]: All patients were followed up for 6 months, and the incisions healed by first intention. There was no significant difference in general data such as surgical site, age, gender, body mass in","[173, 1188, 1012, 1514]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +8,6,number,IV,"[585, 1565, 607, 1585]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +8,7,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +9,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +9,1,abstract,"difference in the length of the lower limbs between the AI group and the 2D group before and after operation, both of which were statistically significant (P<0.05). The accuracy rates of acetabular pr","[175, 141, 1011, 675]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +9,2,abstract,"[Conclusion]: The AIHIP system can achieve precise planning for THA surgery. Compared with the two-dimensional digital template, it has higher accuracy and effectiveness. It can assist the operator to","[174, 695, 1011, 894]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,True,True +9,3,text,Keywords: total hip replacement; artificial intelligence; preoperative planning,"[177, 1011, 932, 1042]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,False,False +9,4,number,V,"[587, 1565, 603, 1583]",figure_inner_text,0.9,"[""panel label / figure inner text: V""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,5,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +10,0,paragraph_title,前言,"[557, 151, 631, 194]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u524d\u8a00""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +10,1,abstract,全髋关节置换术(Total hip arthroplasty,THA)是二十世纪外科手术中最成功的可重复和频繁进行的手术方式之一 $ ^{[1]} $。全髋关节置换术是治疗髋关节畸形、骨关节炎、股骨颈骨折、股骨头坏死、先天性髋关节畸形等髋关节病的有效方法之一 $ ^{[2]} $。由于髋是一种有着独特的解剖学及生物机械特性的复合关节,所以很难对其进行完整的关节活动及受力状态的恢复。2021年美国关,"[175, 212, 1017, 621]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,2,abstract,我国人口结构同样逐渐趋于老龄化,老年髋部骨折发病率逐年增高,此疾病给社会和家庭带来沉重的负担,老年髋部骨折由于其死亡率高,常被称为“人生最后一次骨折”。保守治疗容易引起严重的并发症,比如:坠积性肺炎,臀部压疮,深静脉血栓及肺栓塞,泌尿系统感染,肌肉萎缩等,还会导致原有疾病加重。所以,只要没有明确的外科禁忌证,高龄患者应该尽早进行髋关节的外科治疗。在中国,股骨颈骨折是最常见的髋部骨折,发病率约占全身,"[174, 634, 1017, 994]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,3,abstract,老年股骨颈骨折患者由于严重骨质疏松、骨皮质变薄,为了防止术中骨折,要求手术操作更加小心,良好的术前规划尤为重要。然而骨科医生并没有一个很好的术前计划工具,这导致了术前准备不充分,手术效果多依赖医师经验,髋关节置换手术效果受到严重制约,手术存在较多并发症。目前国内术前规划仍普遍以 X 线胶片模板测量的方式进行,因 X 线胶片放大率不准确 $ ^{[8]} $、拍摄投照角度存在差异 $ ^{[9]} ,"[174, 1009, 1017, 1417]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,4,abstract,在 THA 术前规划领域,X 线平片模板测量及二维术前规划软件出现较早,X 线平片模板测量工具与各类型假体配套,二维术前规划软件则主要包括有,"[173, 1429, 1013, 1510]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +10,5,number,1,"[587, 1565, 603, 1584]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +10,6,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +11,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +11,1,text,mediCAD(德国,HECTEC Company)、Orthoview(比利时,Materialize Company)等。这种类型的二维术前规划虽在一定程度上提高了THA手术的准确度 $ ^{[13]} $,但由于二维影像无法完整反映三维信息,且全程需要手工标定,操作繁琐,要求规划者具有丰富的临床经验,规划可重复性低,尤其对于复杂髋关节疾病手术而言,其可提供的参考作用较小。近年来,为解决二维术,"[175, 153, 1017, 840]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +11,2,text,各项研究表明,人工智能基于医疗图像进行深度学习的技术在临床应用方面具有广阔的前景,加之髋关节病变主要表现为骨性结构的改变,各类相关疾病 CT 图像特征明显,AI 深度神经网络可以模拟人类视觉感知机理,实现有监督与无监督两种类型的视觉感知,其隐藏层中的卷积核群具有共同的参数以及分层的稀疏特性,可以实现格点化的图像(Grid-like topology)的稳健辨识 $ ^{[17]} $,特别适合于对,"[175, 854, 1016, 1120]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +11,3,text,在手术中导航时,除了只有极个别的医院装备了机器人,绝大部分 THA 由术者依靠个人经验和粗略测量来实现,这会极大的提高患者的风险。有经验的外科医生也许能达到很好的手术效果,但是年轻而缺乏经验的外科医生不一定能用经验的方法获得理想的手术结果,甚至会使术后并发症发生率升高 $ ^{[18]} $。,"[177, 1136, 1015, 1307]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +11,4,abstract,因此本研究将海南医学院第一附属医院关节外科于2020年6月至2022年12月收治的100例拟行单侧初次THA治疗的膝骨关节炎患者随机分组,目的在于探讨与成熟的二维数字模板术前规划方式相比,AI在实现精准THA的有效性以及临床适用性。本研究的假设是AIHIP系统的术前计划是比传统的二维手动,"[178, 1322, 1016, 1494]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +11,5,number,2,"[588, 1520, 603, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +11,6,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +12,0,header,海南医学院硕士学位论文,"[492, 86, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +12,1,text,模板更准确地预测假体尺寸和假体位置安放的技术。,"[177, 152, 723, 181]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +12,2,number,3,"[588, 1521, 602, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +12,3,footer,中国知网 https://www.cnki.net,"[38, 1622, 384, 1649]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +13,0,header,海南医学院硕士学位论文,"[491, 85, 698, 109]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +13,1,paragraph_title,1 资料与方法,"[176, 154, 359, 193]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1 \u8d44\u6599\u4e0e\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +13,2,paragraph_title,1.1 纳入与排除标准,"[175, 226, 447, 265]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1 \u7eb3\u5165\u4e0e\u6392\u9664\u6807\u51c6""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,3,text,(1) 纳入标准:,"[186, 284, 354, 317]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,reference_like,reference_numeric_parenthesis,False,True +13,4,text,① 患者具有髋关节置换手术适应证;,"[219, 329, 629, 365]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,5,text,② 首次进行髋关节置换的患者;,"[220, 376, 582, 412]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,6,text,③术前患者自愿签署知情同意书;,"[220, 423, 605, 459]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,7,text,④ 影像学资料完整;,"[221, 470, 462, 505]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,8,text,(2) 受试者排除标准;,"[188, 518, 425, 552]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,reference_like,reference_numeric_parenthesis,False,True +13,9,text,① 患者出现了肌萎缩、肌溶解或外展肌乏力等症状;,"[219, 563, 797, 600]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,10,text,② 患者有智力障碍或无法了解参加试验的必要性;,"[220, 611, 774, 646]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,11,text,③ 患者有吸毒史、酗酒史、滥用药物史;,"[220, 657, 678, 692]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,12,text,④ 肥胖 BMI > 35kg/m²;,"[221, 704, 500, 740]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,13,text,⑤ 糖尿病控制不佳(经药物控制空腹血糖仍 $ \geq $8.0mmol/L);,"[220, 752, 882, 786]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,14,text,⑥ 严重的肝肾功能不全,其标准是:谷丙转氨酶(ALT)或谷草转氨酶,"[219, 798, 1015, 833]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,15,text,(AST)超过了其极限 2.5 倍,且血浆肌酐超过了其极限值;,"[187, 845, 814, 879]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,16,text,⑦ 已知患者有内植物过敏史;,"[220, 892, 557, 927]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,17,text,⑧ 髋关节或身体其他部位存在活动性感染病灶;,"[220, 939, 749, 974]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,18,text,⑨ 组成髋关节的骨盆、股骨近端发现有严重的骨质破坏、肿瘤或其他疾病导致的骨性结构受损的病变。,"[174, 986, 1014, 1066]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,19,text,⑩ 孕妇或哺乳期妇女或 12 个月内计划妊娠的妇女;,"[220, 1079, 797, 1114]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,20,text,① 全身性疾病(包括凝血系统异常,心血管疾病,呼吸道疾病以及其他不适合进行麻醉或外科治疗的患者);体质虚弱或由于其他系统性的原因而无法接受外科治疗,平均生存时间少于2年的患者;,"[173, 1126, 1015, 1254]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,21,text,①患者对手术和手术后的诊疗操作不合作或不适应,预期的依从性较低。,"[220, 1265, 1013, 1300]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +13,22,text,①3 患者既往有髋关节手术史。,"[221, 1312, 560, 1348]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +13,23,footer,中国知网 https://www.cnki.net,"[37, 1620, 385, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +13,24,number,4,"[587, 1520, 603, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,1,paragraph_title,1.2 一般资料,"[177, 156, 365, 191]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2 \u4e00\u822c\u8d44\u6599""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +14,2,text,本研究选取 2020 年 6 月至 2022 年 12 月期间来我院关节外科相同诊疗组因髋关节疾病需行初次全髋关节置换患者进行前瞻性研究。根据纳入标准及排除标准,本研究共纳入患者 100 例(100 髋),按照随机数表法将患者分为 AI 组 50 例(50 髋)和 2D 组(50 髋),其中 AI 组男性 24 例,女性 26 例,左侧髋关节 21 例,右侧髋关节 29 例,平均年龄 $ 56.,"[174, 225, 1015, 675]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,3,paragraph_title,1.3 主要设备,"[177, 778, 364, 813]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.3 \u4e3b\u8981\u8bbe\u5907""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +14,4,text,(1) 硬件:DR 数字 X 射线照相装置(荷兰飞利浦公司),64 排多层螺旋 CT 机(荷兰飞利浦公司),华为手机 p40(中国);,"[176, 845, 1013, 924]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +14,5,text,(2) 软件:AI HIP System(北京长木谷医疗科技有限公司,中国北京),Smart joint 软件(北京长木谷医疗科技有限公司,中国北京),PACS 影像系统(GE 医疗,美国);,"[177, 949, 1015, 1073]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +14,6,text,(3) 其他:标准硬币直径 25mm,U 盘(SanDick)256G;,"[177, 1100, 773, 1130]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +14,7,paragraph_title,1.4 数据获取 1.4.1 影像学数据拍摄,"[176, 1218, 417, 1307]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.4 \u6570\u636e\u83b7\u53d6 1.4.1 \u5f71\u50cf\u5b66\u6570\u636e\u62cd\u6444""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +14,8,footer,,"[176, 1277, 417, 1307]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +14,9,text,(1)CT 扫描标准 $ ^{[19]} $:使用 64 排螺旋 CT 对所有患者髋部进行薄层扫描,取仰卧位,嘱患者手臂上举,双侧大腿内旋,两足尖并拢,身体置于床面中间。扫描层厚:1mm,无间隙、无重叠。扫描范围为髂前下棘至股骨上 1/3,横向切片 1:1 节距,使用螺旋(螺线)扫描。扫描视野:300—400mm,管电压:120kVp,,"[176, 1326, 1014, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +14,10,number,5,"[588, 1520, 603, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,11,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +15,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,1,text,管电流 200—250mA;扫描速度:1 秒/圈,层厚:1mm,导出图像为 DICOM 格式。,"[175, 151, 1012, 230]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,2,text,(2)X 线摄片标准 $ ^{[20]} $:受检者身体垂直平卧于摄影台上,两下肢伸直且两足尖并拢,双足稍内旋 10° -15°;放射范围及检测仪的上缘为髂骨嵴,下缘要求至耻骨联合下 3cm;放射源到图像的间距是 100 厘米;中线对齐于双髂前上棘连接的中点向下 3 cm,并竖直射击至检测器中央。图像要求:髋关节正位片范围包括骨盆上缘至股骨近端 1/3,左右对称。两个大粗隆的内侧边缘只有 1/2 ,"[176, 255, 1014, 567]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,3,paragraph_title,1.4.2 影像学测量参数,"[176, 641, 417, 671]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.4.2 \u5f71\u50cf\u5b66\u6d4b\u91cf\u53c2\u6570""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +15,4,text,(1)下肢长度差异:以坐骨结节下边为参照点,在正常的髋关节正位摄影条件下,测定两个坐骨结节下边与两个坐骨结节连边之间的竖直距离。将双下肢差异大于1cm定义为双下肢不等长。,"[176, 689, 1013, 815]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,5,text,(2)髋臼假体外展角:标准髋关节正位片上,用髋臼假体上外侧和内侧两个端部间的连线和基准线之间的角度,在标准正位下,以两侧的坐骨结节下边缘连线作为基准线,测定髋臼上外侧和内侧两个端部间的角度,即为髋臼假体外展角。,"[175, 840, 1014, 1012]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,6,text,(3)股骨柄-髓腔轴线夹角:通过髋关节正位片,测量假体柄的长轴与股骨长轴间夹角,股骨柄-髓腔轴线夹角小于等于3°为股骨柄中央固定,股骨柄-髓腔轴线夹角大于3°则为内翻固定或外翻固定。,"[176, 1037, 1012, 1163]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,7,text,(4)股骨柄-髓腔比:髋关节正位片上,以股骨小转子上缘、股骨柄假体纵向中点、股骨柄下缘尖端上1cm三处为测量平面,计算股骨柄占髓腔比例,最后以百分比表示。,"[178, 1188, 1014, 1311]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +15,8,number,6,"[587, 1520, 603, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,9,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +16,0,header,海南医学院硕士学位论文,"[492, 85, 698, 109]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +16,1,paragraph_title,2 研究方法,"[175, 156, 328, 192]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2 \u7814\u7a76\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +16,2,text,2020 年 6 月至 2022 年 8 月期间,为本院关节外科相同诊疗组中每位首次接受全髋关节置换术并置入生物型假体者制定术前计划。符合入组条件的患者均接受术前 CT 扫描和常规 X 线检查。测量人员在术前应用 AIHIP 软件和 2D 数字模板进行测量,并将患者分为 AI 组与 2D 组。统计每组方案实施结果,包括髋臼杯假体型号、股骨柄假体型号。通过对这些数据的分析,确定了最适合于髋关节置换术,"[175, 223, 1016, 583]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +16,3,paragraph_title,2.1 术前规划方式 2.1.1 AIHIP 规划,"[175, 668, 417, 758]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.1 \u672f\u524d\u89c4\u5212\u65b9\u5f0f 2.1.1 AIHIP \u89c4\u5212""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +16,4,footer,,"[175, 728, 371, 758]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +16,5,paragraph_title,(1) 数据导入及智能分割,"[189, 768, 459, 800]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (1) \u6570\u636e\u5bfc\u5165\u53ca\u667a\u80fd\u5206\u5272""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +16,6,text,将 DICOM 格式的患者资料数据转为 “.cmg” 格式文件导入 AIHIP 系统,使用以二维 Dense-Unet 为主要结构的神经网络 G-NET 对骨骼进行自动分割,将骨骼分为不同区域,如骨盆区域与股骨区域。然后,通过 AIHIP 系统的 G-NET 对髋臼与股骨进行智能分割,建立骨盆与股骨的三维模型,并通过算法将髋臼与股骨头分离。分离后可单独观察股骨头或髋臼病变及骨缺损情况。,"[174, 818, 1016, 1039]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +16,7,image,,"[279, 1090, 955, 1373]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +16,8,figure_title,图 1 AIHIP 系统自动识别解剖位点,"[455, 1440, 775, 1467]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 1 AIHIP \u7cfb\u7edf\u81ea\u52a8\u8bc6\u522b\u89e3\u5256\u4f4d\u70b9""]",figure_caption,0.85,,legend_like,none,False,False +16,9,number,7,"[588, 1520, 603, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +16,10,footer,中国知网 https://www.cnki.net,"[37, 1621, 385, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +17,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +17,1,paragraph_title,(2) 矫正与测量,"[189, 143, 364, 173]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (2) \u77eb\u6b63\u4e0e\u6d4b\u91cf""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +17,2,text,AIHIP 系统智能识别髋关节解剖标志点,如坐骨结节、髂前上棘、耻骨联合、大转子、小转子等,并根据骨骼结构自动测量髋臼大小、髓腔大小、股骨机械轴等数据。通过双侧髂前上棘与耻骨联合形成平面及尺骨联合中点与尾骨中点的连线,将骨盆调整至中立位,为选择合适大小的髋臼假体,调整髋臼假体前倾角及外展角做准备。根据识别的髋部解剖点,智能计算患者双下肢长度、双侧联合偏心距等参数,为安放股骨柄假体及术者手术提供数据,"[174, 193, 1015, 458]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +17,3,image,,"[279, 478, 953, 813]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +17,4,figure_title,图 2 AIHP 系统智能识别髋关节骨性标志点,"[413, 830, 817, 856]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 2 AIHP \u7cfb\u7edf\u667a\u80fd\u8bc6\u522b\u9acb\u5173\u8282\u9aa8\u6027\u6807\u5fd7\u70b9""]",figure_caption,0.85,,legend_like,none,False,False +17,5,paragraph_title,(3) 假体规划与模拟截骨,"[189, 910, 456, 940]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (3) \u5047\u4f53\u89c4\u5212\u4e0e\u6a21\u62df\u622a\u9aa8""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +17,6,text,在 AIHIP 系统智能识别并标定的解剖标志点的基础上,依据测算出的髋臼数据,自动识别髋臼假体安放位置并从数据库中智能匹配合适的髋臼杯型号。将髋臼假体数据导入患者 CT 数据中,并计划髋臼杯假体以外展角 45°,前倾角 15-20° 安放。本步骤中可对髋臼假体的位置、型号大小、外展角及前倾角进行调整,AIHIP 系统可根据调整数据实时显示髋臼假体与髋臼前后壁位置关系,并计算出调整后的髋臼覆盖率。,"[174, 960, 1015, 1226]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +17,7,number,8,"[588, 1520, 603, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +17,8,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,0,header,海南医学院硕士学位论文,"[493, 85, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +18,1,image,,"[377, 155, 813, 440]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,2,figure_title,图 3 AIHP 系统自动匹配假体型号,"[436, 466, 754, 493]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 3 AIHP \u7cfb\u7edf\u81ea\u52a8\u5339\u914d\u5047\u4f53\u578b\u53f7""]",figure_caption,0.85,,legend_like,short_fragment,False,False +18,3,image,,"[381, 556, 573, 742]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,4,image,,"[618, 554, 811, 742]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,5,image,,"[381, 753, 573, 942]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,6,image,,"[618, 754, 811, 941]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,7,figure_title,图 4 AIHIP 系统安放髋臼假体并展示三维模拟位置,"[360, 963, 828, 990]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 4 AIHIP \u7cfb\u7edf\u5b89\u653e\u9acb\u81fc\u5047\u4f53\u5e76\u5c55\u793a\u4e09\u7ef4\u6a21\u62df\u4f4d\u7f6e""]",figure_caption,0.85,,legend_like,none,False,False +18,8,text,依据 AIHIP 软件识别的股骨髓腔形态与髓腔大小,自动匹配相应股骨柄。通过之前确定的髋臼及股骨旋转中心、双下肢长度、联合偏心距等匹配与安放合适的股骨柄假体及股骨柄球头。之后可根据假体安放后的双下肢长度及偏心距等对股骨柄安放深度、股骨柄前倾角、股骨内外翻角度微调,直至假体大小、位置、角度达到满意。软件根据假体截骨线对股骨三维模型进行自动截骨,显示完成股骨侧规划。,"[174, 1052, 1015, 1319]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +18,9,number,9,"[588, 1520, 603, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +18,10,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,0,header,海南医学院硕士学位论文,"[493, 85, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +19,1,image,,"[238, 143, 951, 482]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +19,2,figure_title,图 5 AIHIP 自动规划股骨柄假体,"[446, 497, 744, 524]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 5 AIHIP \u81ea\u52a8\u89c4\u5212\u80a1\u9aa8\u67c4\u5047\u4f53""]",figure_caption,0.85,,legend_like,short_fragment,False,False +19,3,text,髋臼假体与股骨假体规划完成后,AIHIP 软件显示最终规划的髋臼杯型号、股骨柄型号、髋臼外展角、髋臼前倾角等参数,同时显示术前与术后及患侧与对侧的患肢长度及联合偏心距等。,"[175, 586, 1012, 710]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +19,4,paragraph_title,(4) 模拟髋关节极限运动状态,"[189, 728, 505, 759]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: (4) \u6a21\u62df\u9acb\u5173\u8282\u6781\u9650\u8fd0\u52a8\u72b6\u6001""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +19,5,text,模拟髋关节的极限运动状态是指,在股骨柄与股骨锁死的情况下,进行围绕旋转中心的极限前屈、后伸等动作。这些动作可以帮助医生和研究人员更好地理解髋关节在不同运动状态下的力学特性和生物力学行为。在这种情况下,股骨柄和股骨之间的运动非常有限,因此需要进行极限运动测试来了解关节的极限运动范围。,"[174, 778, 1015, 996]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +19,6,paragraph_title,2.1.2 2D 数字化模板规划,"[175, 1086, 451, 1116]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.1.2 2D \u6570\u5b57\u5316\u6a21\u677f\u89c4\u5212""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +19,7,text,导入带有比例硬币的髋关节正位片,设定比例硬币长度为 25mm,纠正假体比例与髋关节正位片比例一致。鉴于髋臼假体的要求 $ ^{[21]} $,应当注意以下两点:①髋臼杯下缘需要保持平行状态,并且与泪滴下缘保持相同高度。②髋臼杯内侧缘距离泪滴外侧缘 5—10mm,位于髂坐线上,杯外侧缘超过髋臼上缘骨质,适当保留软骨下骨,保证假体覆盖率。股骨假体要求 $ ^{[22]} $:①根据股骨髓腔形状选择合适,"[174, 1134, 1015, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +19,8,number,10,"[584, 1521, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +19,9,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,0,header,海南医学院硕士学位论文,"[492, 85, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,1,text,及要求。根据上述标准选择髋臼杯与股骨柄的型号。,"[177, 151, 723, 182]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +20,2,image,,"[354, 262, 891, 715]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +20,3,figure_title,图 6 Smart joint 软件规划示意图,"[468, 736, 764, 763]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 6 Smart joint \u8f6f\u4ef6\u89c4\u5212\u793a\u610f\u56fe""]",figure_caption,0.85,,unknown_like,none,False,False +20,4,paragraph_title,2.2 手术方法,"[175, 861, 358, 895]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.2 \u624b\u672f\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +20,5,text,本文介绍了 100 例进行第一次 THA 的治疗方案,并通过随机方法将患者分成了 AI 组和 2D 组,每组有 50 例患者。其中 AI 组用 AIHIP 系统进行规划术前规划,根据 AIHIP 系统建议的股骨颈截骨量以及髋臼外展角和前倾角进行髋臼磨挫。2D 组用 Smart Joint 软件进行术前规划,按照标准后外侧入路全髋关节置换术式进行手术,髋臼外展角按照 45° 进行磨挫规划。两种治疗方,"[174, 928, 1014, 1335]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,6,text,手术过程:在患者身上,首先需要确定切口的起点,在大粗隆尖上方 3.0cm 处标记。随后,切口开始沿着臀大肌纤维方向向下延伸,直至股骨大转子下方 5.0cm 处,整个切口长度约为 15.0cm。接下来,依次切开组织,以显露出大粗隆。,"[175, 1359, 1015, 1484]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +20,7,number,11,"[583, 1521, 607, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,8,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +21,1,text,分离后方,显露出相应的外旋肌群。切断间窝位置,并且进行牵开外旋肌群的处理,同时还应保护坐骨神经的健康状态。随后,需要对脂肪组织进行分离,以显露出相应的关节囊,并切开囊来实现脱位。对大、小转子区域,需要对相应的股骨颈进行截骨的基本操作,然后再进行股骨头的取出操作。完成这些操作之后,使用髋臼拉钩来有效显露,并彻底清理相关软组织,这样可以显露出真性髋臼,为接下来的手术操作做好准备。使用髋臼锉从 38 m,"[175, 152, 1016, 839]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,2,paragraph_title,2.3 术后处理,"[176, 925, 357, 960]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.3 \u672f\u540e\u5904\u7406""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +21,3,text,术后采取相应的禁食处理 6 小时,结合基础病状况调整饮食。术后 1 天内,提供相应的护理、监护以及吸氧等支持。手术之后,提供相应的低分子量肝素,有效预防血栓 24 小时。抗生素方面的具体运用是 48 小时。出院后口服利伐沙班至第 12 天;切口 2—3 天进行换药操作 1 次。手术之后的第 14 天,结合具体的愈合状况进行拆线。手术之后监控具体的引流量,低于 50ml 拔除。,"[174, 992, 1013, 1212]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,4,text,术后第 1 天:指导患者平卧于床上行踝泵锻炼以及股四头肌锻炼,促进患肢血液循环以及肌肉力量的恢复,防止下肢深静脉血栓形成。,"[176, 1236, 1013, 1314]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,5,text,术后第 2 至 3 天:嘱患者在不负重或者负重条件下进行患侧下肢肌力及髋膝关节活动度训练,训练应包含相应的屈髋屈膝动作(屈髋方面低于 $ 90^{\circ} $ )、髋关节外展以及伸直,进行相应的直腿抬高等动作。,"[176, 1340, 1011, 1464]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +21,6,number,12,"[584, 1520, 607, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +21,7,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +22,0,header,海南医学院硕士学位论文,"[491, 85, 698, 109]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +22,1,text,术后 3 天至 2 周:鼓励患者主动床旁站立,在助行器辅助下尝试病房内行走的基础上进行步态训练及身体平衡性训练。,"[175, 151, 1013, 231]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +22,2,text,术后 2 周至 3 个月,患者应在出院后的 2 周内进行轻度锻炼。在接下来的 3 月内避免髋关节屈曲大于 90 度,关节活动要求恢复术前日常活动。,"[175, 255, 1014, 333]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +22,3,paragraph_title,2.4 观察项目,"[175, 435, 356, 471]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.4 \u89c2\u5bdf\u9879\u76ee""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +22,4,text,(1) 术前资料:包括一般资料,如 BMI、年龄和性别。术前患者下肢长度差值,术前髋关节 Harris 评分,AI 组及 2D 组两种方式规划时间。,"[175, 502, 1009, 582]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +22,5,text,(2) 术中资料:手术时间(切皮至关闭手术切口),术中出血量及术中实际所采用的髋关节假体型号。,"[175, 604, 1013, 684]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +22,6,text,(3) 术后资料:术后双下肢长度差值,术后髋关节正位片外展角度,术后股骨柄—髓腔轴线夹角,术后股骨柄—髓腔比,术后1月、3月、6月髋关节Harris评分。,"[175, 718, 1015, 849]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +22,7,paragraph_title,2.5 统计学方法,"[175, 993, 387, 1029]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.5 \u7edf\u8ba1\u5b66\u65b9\u6cd5""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +22,8,text,对所有数据进行处理时,采用 SPSS 25.0 软件。正态分布的计量数据使用 t 检验进行处理,非正态分布的计量数据使用秩和检验进行处理,等级数据则使用卡方检验。计量数据以均数±标准差的形式进行描述。显著性水平 P<0.05 表示差异具有统计学意义。,"[174, 1060, 1015, 1233]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +22,9,number,13,"[584, 1520, 607, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +22,10,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +23,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +23,1,paragraph_title,3 研究结果,"[176, 155, 328, 192]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3 \u7814\u7a76\u7ed3\u679c""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +23,2,paragraph_title,3.1 术前资料比较 3.1.1 一般资料,"[175, 228, 418, 318]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1 \u672f\u524d\u8d44\u6599\u6bd4\u8f83 3.1.1 \u4e00\u822c\u8d44\u6599""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +23,3,footer,,"[175, 287, 348, 318]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +23,4,text,AI 组和 2D 组的患者在手术部位、年龄、性别、体重指数(BMI)和髋关节 Harris 评分等一般资料比较的差异均无统计学意义(P>0.05),AI 组与 2D 组的观察资料具有可比性。(表 1)。,"[174, 336, 1016, 462]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +23,5,figure_title,表 1 AI 组和 2D 组术前一般资料比较,"[396, 486, 792, 516]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 1 AI \u7ec4\u548c 2D \u7ec4\u672f\u524d\u4e00\u822c\u8d44\u6599\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +23,6,table,
因素AI 组 (n=50)2D 组 (n=50)$ t/\chi^{2} $P
年龄(岁)$ 56.52 \pm 13.45 $$ 60.60 \pm 12.10 $-1.5920.1,"[167, 521, 1021, 1047]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +23,7,vision_footnote,注:AI 组和 2D 组患者术前一般资料无明显差异,无统计学意义。,"[175, 1061, 783, 1090]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u548c 2D \u7ec4\u60a3\u8005\u672f\u524d\u4e00\u822c\u8d44\u6599\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u3002""]",footnote,0.7,,unknown_like,none,True,True +23,8,paragraph_title,3.1.2 术前规划时间,"[197, 1183, 418, 1214]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.1.2 \u672f\u524d\u89c4\u5212\u65f6\u95f4""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +23,9,text,AI 组术前规划时间最长 451 秒,最短 355 秒,平均规划时间为 $ 401.56 \pm 31.36 $ 秒。2D 组术前规划时间最长为 312 秒,最短规划时间为 210 秒,平均规划时间为 $ 266.48 \pm 29.42 $ 秒。AI 组术前规划时间略长于 2D 组,且两组在术前规划时间上的比较差异有统计学意义(P < 0.05)(表 2)。,"[173, 1232, 1016, 1405]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,10,number,14,"[583, 1520, 609, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +23,11,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +24,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +24,1,figure_title,表 2 AI 组和 2D 组术前规划时间比较,"[398, 143, 791, 171]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 2 AI \u7ec4\u548c 2D \u7ec4\u672f\u524d\u89c4\u5212\u65f6\u95f4\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +24,2,table,
因素AI 组(n=50)2D 组(n=50)$ t/\chi^{2} $P
术前规划时间(秒)$ 401.56 \pm 31.36 $$ 266.48 \pm 29.42 $0.252,"[168, 171, 1019, 285]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +24,3,vision_footnote,注:AI 组和 2D 组规划时间比较有明显差异,有统计学意义。,"[175, 301, 742, 329]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u548c 2D \u7ec4\u89c4\u5212\u65f6\u95f4\u6bd4\u8f83\u6709\u660e\u663e\u5dee\u5f02\uff0c\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002""]",footnote,0.7,,unknown_like,none,True,True +24,4,chart,,"[233, 398, 965, 817]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +24,5,figure_title,图 7 AI 组与 2D 组术前规划时间箱型图,"[411, 861, 778, 889]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 7 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u524d\u89c4\u5212\u65f6\u95f4\u7bb1\u578b\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +24,6,paragraph_title,3.2 术中资料比较 3.2.1 手术时间,"[175, 954, 417, 1044]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.2 \u672f\u4e2d\u8d44\u6599\u6bd4\u8f83 3.2.1 \u624b\u672f\u65f6\u95f4""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +24,7,footer,,"[198, 1014, 371, 1044]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +24,8,text,AI 组手术时间最长为 122 分钟,最短手术时间为 60 分钟,平均手术时间为 $ 92.66 \pm 14.30 $ 分钟。2D 组手术时间最长为 157 分钟,最短手术时间为 70 分钟,平均手术时间为 $ 103.82 \pm 16.05 $ 分钟。两组在手术时间的比较有明显差异,有统计学意义(P < 0.05)(表 3、图 8)。两组手术时间对比,AI 组能有效的缩短手术时间。,"[172, 1064, 1016, 1283]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,9,number,15,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +24,10,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +25,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +25,1,chart,,"[221, 150, 981, 589]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +25,2,figure_title,图 8 AI 组与 2D 组手术时间箱型图,"[432, 622, 757, 650]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 8 AI \u7ec4\u4e0e 2D \u7ec4\u624b\u672f\u65f6\u95f4\u7bb1\u578b\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +25,3,paragraph_title,3.2.2 术中出血量,"[198, 693, 393, 722]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.2.2 \u672f\u4e2d\u51fa\u8840\u91cf""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +25,4,text,AI 组术中出血量最大为 700 ml,最小为 30 ml,平均术中出血为 207.60±131.98 ml。2D 组术中出血量最大为 800 ml,最小为 100 ml,平均术中出血为 274.00±150.02 ml。两组在术中出血量的差异有统计学意义(P<0.05),且 AI 组手术出血量少于 2D 组(表 3)。,"[174, 743, 1017, 913]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +25,5,chart,,"[212, 929, 985, 1369]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +25,6,figure_title,图 9 AI 组与 2D 组术中出血量箱型图,"[422, 1400, 767, 1427]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 9 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u4e2d\u51fa\u8840\u91cf\u7bb1\u578b\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +25,7,number,16,"[583, 1520, 609, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +25,8,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +26,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +26,1,paragraph_title,3.2.3 假体预测准确性,"[197, 143, 441, 173]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.2.3 \u5047\u4f53\u9884\u6d4b\u51c6\u786e\u6027""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +26,2,text,本研究以术前规划假体型号与术中实际应用假体型号完全一致为规划准确。研究中采用的全髋关节人工假体为美国强生公司 PINNACLE 非骨水泥型生物杯和 TRILOCK 非骨水泥型生物柄,其中髋臼杯最小号为 42 号,型号依次以 44、46、48 递增至 66 号。股骨柄最小号为 0 号,型号依次以 1、2、3 递增至 12 号。AI 组术前规划与术中实际应用髋臼杯假体与股骨柄假体准确率为 76%(38,"[173, 193, 1016, 694]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,3,chart,,"[225, 769, 947, 1186]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +26,4,figure_title,图 10 AI 组与 2D 组髋臼假体型号分布,"[417, 1214, 772, 1240]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 10 AI \u7ec4\u4e0e 2D \u7ec4\u9acb\u81fc\u5047\u4f53\u578b\u53f7\u5206\u5e03""]",figure_caption,0.85,,legend_like,none,False,False +26,5,number,17,"[584, 1520, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +26,6,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +27,0,header,海南医学院硕士学位论文,"[491, 85, 698, 109]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +27,1,chart,,"[226, 187, 946, 606]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +27,2,figure_title,图 11 AI 组与 2D 组股骨柄假体型号分布,"[407, 631, 783, 659]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 11 AI \u7ec4\u4e0e 2D \u7ec4\u80a1\u9aa8\u67c4\u5047\u4f53\u578b\u53f7\u5206\u5e03""]",figure_caption,0.85,,legend_like,none,False,False +27,3,figure_title,表 3 AI 组和 2D 组术中资料比较,"[422, 762, 768, 792]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 3 AI \u7ec4\u548c 2D \u7ec4\u672f\u4e2d\u8d44\u6599\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +27,4,table,0.05)(表 4)。AI 组与 2D 组术前规划在改善髋臼假体外展角上无明显差异,但 AI 组术后髋臼外展角相关性较 2D 组更强(图 12)。,"[175, 264, 1017, 483]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +28,4,chart,,"[271, 505, 964, 953]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +28,5,figure_title,图 12 AI 组与 2D 组术后髋臼假体外展角分布情况,"[364, 980, 824, 1007]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 12 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u9acb\u81fc\u5047\u4f53\u5916\u5c55\u89d2\u5206\u5e03\u60c5\u51b5""]",figure_caption,0.85,,legend_like,none,False,False +28,6,paragraph_title,3.3.2 术后两组股骨柄一髓腔比例比较,"[198, 1101, 605, 1131]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.3.2 \u672f\u540e\u4e24\u7ec4\u80a1\u9aa8\u67c4\u4e00\u9ad3\u8154\u6bd4\u4f8b\u6bd4\u8f83""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +28,7,text,AI 组术后股骨柄-髓腔比最大为 94.85%,最小为 84.5%,平均股骨柄-髓腔比为 $ 89.34 \pm 3.09\% $。2D 组股骨柄-髓腔比最大为 93.35%,最小为 81%,平均股骨柄-髓腔比为 $ 86.35 \pm 3.42\% $。两组股骨柄-髓腔比差异明显,有统计学意义(P<0.05)(表 4)。AI 术前规划能更加准确的规划股骨假体大小,获得更优的股骨柄-髓腔占比结,"[173, 1151, 1016, 1370]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +28,8,number,19,"[584, 1520, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +28,9,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +29,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +29,1,chart,,"[279, 161, 962, 525]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +29,2,figure_title,图 13 AI 组与 2D 组术后股骨柄-髓腔比例分布情况,"[354, 560, 836, 587]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 13 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u80a1\u9aa8\u67c4\uff0d\u9ad3\u8154\u6bd4\u4f8b\u5206\u5e03\u60c5\u51b5""]",figure_caption,0.85,,legend_like,none,False,False +29,3,paragraph_title,3.3.3 术后两组股骨柄一髓腔轴线比较,"[197, 641, 606, 671]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.3.3 \u672f\u540e\u4e24\u7ec4\u80a1\u9aa8\u67c4\u4e00\u9ad3\u8154\u8f74\u7ebf\u6bd4\u8f83""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +29,4,text,AI 组术后股骨柄-髓腔轴线夹角最大 3.12°,最小为 1.13°,平均股骨柄-股骨轴线夹角为 2.67±0.43。2D 组术后股骨柄-髓腔轴线夹角最大为 4.11°,最小为 1.12°,平均股骨柄-髓腔轴线夹角为 2.66±0.62°。两组比较差异不明显,无统计学意义(P>0.05)(表 4)。本研究以股骨柄-髓腔轴线夹角≤3°即股骨柄中心固定为准确,>3°股骨柄外翻固定或内翻固定为不准确。A,"[174, 689, 1015, 1098]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +29,5,number,20,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +29,6,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +30,0,header,海南医学院硕士学位论文,"[491, 85, 698, 109]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +30,1,chart,,"[195, 155, 1003, 622]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +30,2,figure_title,图 14 AI 组与 2D 组术后股骨柄—髓腔夹角分布情况,"[353, 653, 836, 681]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 14 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u80a1\u9aa8\u67c4\u2014\u9ad3\u8154\u5939\u89d2\u5206\u5e03\u60c5\u51b5""]",figure_caption,0.85,,legend_like,none,False,False +30,3,figure_title,表 4 AI 组和 2D 组术后假体位置比较,"[398, 756, 791, 787]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 4 AI \u7ec4\u548c 2D \u7ec4\u672f\u540e\u5047\u4f53\u4f4d\u7f6e\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +30,4,table,
因素AI 组 (n=50)2D 组 (n=50)$ t/\chi^{2} $P
手术时间(分钟)$ 92.66 \pm 14.30 $$ 103.82 \pm 16.05 $-3.670
因素AI 组 (n=50)2D 组 (n=50)$ t/\chi^{2} $P
髋臼外展角(°)$ 42.07 \pm 4.78 $$ 41.26 \pm 5.19 $0.6590.4,"[168, 791, 1022, 1285]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +30,5,vision_footnote,注:AI 组与 2D 组术后髋臼外展角、股骨柄-股骨轴线夹角及股骨柄-股骨轴线夹角准确率比较无明显差异,无统计学意义。与 2D 组相比,AI 组股骨柄-髓腔比率更优,股骨柄稳定性更强,两组结果对比有差异,具有统计学意义。,"[173, 1298, 1018, 1390]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u4e0e 2D \u7ec4\u672f\u540e\u9acb\u81fc\u5916\u5c55\u89d2\u3001\u80a1\u9aa8\u67c4\uff0d\u80a1\u9aa8\u8f74\u7ebf\u5939\u89d2\u53ca\u80a1\u9aa8\u67c4\uff0d\u80a1\u9aa8\u8f74\u7ebf\u5939\u89d2\u51c6\u786e\u7387\u6bd4\u8f83\u65e0\u660e\u663e\u5dee\u5f02\uff0c\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u4e0e""]",footnote,0.7,,unknown_like,none,True,True +30,6,number,21,"[582, 1519, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +30,7,footer,中国知网 https://www.cnki.net,"[37, 1620, 385, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +31,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +31,1,paragraph_title,3.3.4 术后两组双下肢长度比较,"[196, 143, 537, 173]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3.3.4 \u672f\u540e\u4e24\u7ec4\u53cc\u4e0b\u80a2\u957f\u5ea6\u6bd4\u8f83""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +31,2,text,AI组和2D组术前与术后双下肢长度组间比较差异无统计学意义(P<0.05),AI组和2D组术前与术后双下肢长度比较差异明显,均有统计学意义(P<0.05)。AI组与2D组通过手术都有效地改善了下肢长度,当我们定义双下肢长度差异>5mm为下肢不等长,AI组中有1名患者发生下肢不等长,而2D组有2名患者(图15,图16)。另外,AI组术后下肢长度差异平均值为0.06±0.36cm,较2D组术后下肢长度,"[173, 192, 1016, 506]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +31,3,figure_title,表 5 AI 组和 2D 组术后双下肢长度差异比较,"[385, 585, 851, 616]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 5 AI \u7ec4\u548c 2D \u7ec4\u672f\u540e\u53cc\u4e0b\u80a2\u957f\u5ea6\u5dee\u5f02\u6bd4\u8f83""]",figure_caption,0.85,,legend_like,none,False,False +31,4,table,
参数术前术后t值p值
2D组(cm)$ -1.01 \pm 0.78 $$ 0.07 \pm 0.30 $-8.8420.00
AI组(cm)
组别n术后1月(分)术后3月(分)术后6月(分)F值P值
AI组50$ 73.14 \pm 6.82 $$ 81.98 \pm 2.38 $$ 9,"[166, 1123, 1021, 1376]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +32,7,vision_footnote,注:AI 组与 2D 组相比,术后 1 月和术后 6 月髋关节评分更高,AI 术前规划精准规划髋关节活动角度及假体位置,促进患者术后关节功能恢复。,"[173, 1386, 1014, 1446]",footnote,0.7,"[""vision_footnote label: \u6ce8\uff1aAI \u7ec4\u4e0e 2D \u7ec4\u76f8\u6bd4\uff0c\u672f\u540e 1 \u6708\u548c\u672f\u540e 6 \u6708\u9acb\u5173\u8282\u8bc4\u5206\u66f4\u9ad8\uff0cAI \u672f\u524d\u89c4\u5212\u7cbe\u51c6\u89c4\u5212\u9acb\u5173\u8282\u6d3b\u52a8\u89d2\u5ea6\u53ca\u5047\u4f53\u4f4d\u7f6e\uff0c""]",footnote,0.7,,unknown_like,none,True,True +32,8,number,23,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +32,9,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +33,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +33,1,chart,,"[204, 149, 995, 701]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +33,2,figure_title,图 17 AI 组与 2D 组术前术后髋关节 Harris 评分估算边际平均值,"[300, 746, 887, 774]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 17 AI \u7ec4\u4e0e 2D \u7ec4\u672f\u524d\u672f\u540e\u9acb\u5173\u8282 Harris \u8bc4\u5206\u4f30\u7b97\u8fb9\u9645\u5e73\u5747\u503c""]",figure_caption,0.85,,legend_like,none,False,False +33,3,number,24,"[583, 1520, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +33,4,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +34,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +34,1,paragraph_title,4 讨论,"[175, 155, 270, 191]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 4 \u8ba8\u8bba""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +34,2,text,"从 19 世纪 60 年代起,全髋关节置换术就已经发展成为一种常见的外科手术,它可以有效地治疗髋部骨关节炎、病理性关节磨损等慢性疾病。随着科学技术的发展,现代全髋关节置换术已经取得了长足的进步与发展,它可以更好地恢复患者的关节活动能力。髋关节不稳定、机械松动、术后脱位、双下肢不等长等因素是导致 THA 翻修和影响髋关节手术成功率的主要因素 $ ^{[23,24]} $。因此,完备的术前准备和设计对","[174, 224, 1016, 678]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +34,3,text,随着数字化骨科技术的发展,全髋关节置换术的术前规划方式也从广泛应用的二维胶片模板与数字化模板规划方式发展到基于 CT 或 MRI 扫描的三维模板规划方式,假体型号的预测精准度也在不断地提高。然而三维规划方式不仅对于规划者的专业知识要求十分严苛,而且操作过程繁琐耗时,硬件设备要求高,无法在偏远地区医院与基层医院推广。本研究使用基于人工智能的三维规划软件,与传统的二维模板相比精准度得到了大幅度提高,同,"[174, 701, 1016, 1203]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +34,4,text,二维模板规划是目前应用最广泛的规划方法,具备操作简单、辐射剂量低、技术要求低、价格低等优点,但同样存在放大倍率不确定、提供信息量少、测量误差大等缺点。数字模板的准确性取决于放大标记的准确性及其在髋关节水平上估计骨骼真实放大率的能力,放大率差异最常见的解决方法是使用硬币或金属球进行外部标记 $ ^{[8]} $。由于二维模板术前规划是基于髋关节正位片(前后位投影)进行操作,无法准确反映髋关节的复杂骨,"[174, 1226, 1016, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +34,5,number,25,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +34,6,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +35,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +35,1,text,线投射的同一平面发生重叠时,容易导致术前规划的误差。另外,患者规划侧出现股骨弯曲或旋转时,髋关节生物力学测量则发生股骨偏移等误差,影响假体型号与放置位置的选择 $ ^{[26]} $。,"[176, 151, 1014, 275]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +35,2,text,三维模板规划是基于高分辨率 CT 或 MRI 图像,利用计算机软件对患者数据进行分割处理后转化为虚拟三维模型,并在此基础上进行假体规划和手术过程模拟。三维模板规划的优势在于 CT 成像可清晰显示髋臼前倾角、髋臼外展角、髋臼前后壁厚度、股骨前倾角以及股骨近端等解剖结构。在复杂的病例和 THA 翻修手术中,三维模板规划可直观地展示髋关节骨性结构的骨溶解和骨丢失等情况 $ ^{[27]} $。基于 AI,"[175, 303, 1016, 944]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,3,text,本研究显示,AI 组术前规划与术中实际应用髋臼杯假体与股骨柄假体准确率为 76%(38/50)和 70%(35/50),2D 组术前规划与术中实际应用髋臼杯与股骨柄假体准确率为 58%(29/50)和 54%(27/50)。髋臼杯假体与股骨柄假体在 1 个型号范围内准确率,AI 组与 2D 组分别为 96%(48/50),96%(48/50)和 76%(38/50),70%(35/50)。与 2D,"[175, 968, 1016, 1513]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +35,4,number,26,"[583, 1521, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +35,5,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +36,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +36,1,text,当的方案调整是有必要的。,"[177, 151, 460, 182]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +36,2,text,"股骨和髋臼精准的生物力学重建对于术后满意的髋关节功能至关重要 $ ^{[31]} $。若放置不当,可能会导致假体撞击等并发症。为了减少类似术后并发症的发生,对于安放髋臼假体而言,最关键的是准确地定位髋关节旋转中心 $ ^{[32]} $。此外,髋关节的旋转中心对于恢复肌肉功能 $ ^{[33,34]} $、关节稳定性 $ ^{[35,36]} $和髋关节假体寿命 $ ^{[37]} $也至关重要。","[175, 208, 1017, 946]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +36,3,text,1993 年,Dorr $ ^{[40]} $首次在骨盆正位片依据股骨一髓腔比将股骨髓腔分为香槟杯型、普通型和烟囱型,这种分型方式至今被骨科医生们使用。二维术前规划选择股骨假体利用的相同的原理。然而有学者发现,股骨髓腔同一水平面,冠状面与矢状面髓腔直径存在明显差异 $ ^{[41]} $。另外,Mikayla Forness $ ^{[42]} $等人研究发现,髋关节旋转 15°,屈曲 5° 的变,"[174, 968, 1016, 1468]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +36,4,number,27,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +36,5,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +37,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +37,1,text,良好的术前规划,可以避免假体置入的盲目性,避免反复试模与压配、调整过程造成的手术时间的延长。手术时间的缩短,可减少切口创面的渗血。由AI组与2D组研究结果可知,AI组平均手术时间为92.66±14.30分钟;2D组平均手术时间为103.82±16.05,AI组术中平均出血量为207.60±131.98ml;2D组术中出血量274.00±150.02ml,AI组与2D组术中出血量与手术时间存在正相关,"[175, 153, 1015, 464]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +37,2,text,根据相关研究显示 $ ^{[44-46]} $,精准的假体位置能够改善人工关节活动范围,延长人工关节使用寿命,有效避免假体撞击、假体不稳、假体脱位等并发症。本研究发现,在术后3个月时,两组的Harris指数没有显著差异(P>0.05);但在术后1个月和6个月时,AI组的数据明显高于2D组,差异具有统计学意义(P<0.05)。通过比较术后两组髋关节Harris评分,我们认为AI术前规划提供给医生精准,"[175, 490, 1015, 802]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +37,3,text,我们的研究同时还比较了两种规划方法的规划时间,结果显示,AI 组的规划时间为 $ 401.56 \pm 31.36 $ 秒,比 2D 组规划时间 $ 266.48 \pm 29.42 $ 秒略长。关于术前规划时间的研究既往也有学者报道,Robert $ ^{[47]} $等人报道使用醋酸盐模板法进行模板化的平均时间为 119 秒,而使用数字模板法进行的平均时间则为 154 秒,平均差异为 35,"[175, 827, 1016, 1373]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +37,4,text,髋关节置换术作为骨科中难度与复杂程度较大的手术,完善的手术器械及假体备货同样影响手术的成功率。传统的术前器械与假体准备往往通过多套手,"[177, 1398, 1013, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +37,5,number,28,"[583, 1520, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +37,6,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +38,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +38,1,text,术器械及大量假体型号备货预防与解决手术过程中假体不匹配、假体大小偏差等问题,但由于髋臼与股骨个体发育差异,仍然出现假体与患者髋臼或股骨髓腔不匹配等情况。另外,大量的器械和假体备货提高手术相关的消毒成本,增加供应室相关工作人员的工作压力与负担,可能间接导致器械无菌消毒不合格,手术感染风险升高等问题。研究过程中我们发现,人工智能三维术前规划能够提供更加精准的假体大小和型号,器械与假体只需根据术前规划报,"[174, 151, 1015, 512]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +38,2,text,骨科是医患纠纷较为常见的科室。因此,对医患交流质量有极高的要求 $ ^{[50]} $。优秀的术前沟通对于获得患者的信任至关重要,也是避免纠纷的关键 $ ^{[51]} $。以往医生进行术前谈话,多依靠患者的X线,CT或者MRI等影像学资料。患者及家属理解晦涩难懂的影像学资料存在一定的困难,同时,要求他们在理解的基础上了解手术必要性与相关风险具有非常大的难度。我们发现,人工智能术前规划提供直观的三,"[175, 535, 1015, 944]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +38,3,text,髋关节作为人体最复杂的关节之一,髋关节置换术的成功率与医师经验有关,高年资医师的手术预后较好,对于青年医师初期进行关节置换手术操作,手术效果往往不是很理想。人工智能三维术前规划,通过三维骨性结构的重建提供清晰的髋臼病损改变,预测术中可能出现的困难,规避术中并发症,并对手术过程进行预测。另外,AI术前规划准确规划术前假体大小及位置角度,提供了一种学习假体选择和安放的良好方式,缩短髋关节置换术的学习周,"[174, 966, 1016, 1281]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +38,4,number,29,"[583, 1520, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +38,5,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +39,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +39,1,paragraph_title,5 研究的局限性,"[175, 156, 386, 192]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 5 \u7814\u7a76\u7684\u5c40\u9650\u6027""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +39,2,text,本研究所采用的 AIHIP 系统可以准确预测假体型号,并在术后髋关节功能评测上获得了良好的结果。然而仍然存在一定的局限性:①本研究只纳入了强生公司的单类型假体,未对其他型号假体及其他品牌假体进行评测。②本研究仅纳入单侧初次全髋关节置换患者,未对双侧全髋关节置换、先天性髋关节发育不良、髋关节假体失效、初次髋关节置换术后髋臼严重缺损需翻修等患者进行应用研究。③本研究术后假体位置及稳定性仅依靠髋关节正位,"[174, 223, 1015, 773]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +39,3,number,30,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +39,4,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +40,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +40,1,paragraph_title,6 结论,"[175, 156, 269, 192]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 6 \u7ed3\u8bba""]",subsection_heading,0.6,body_zone,reference_like,reference_numeric_dot,True,True +40,2,text,通过短期临床随访,AIHIP系统可以辅助术者在THA手术中实现精准的假体型号与假体位置安放,减少术中反复磨挫及试模次数,缩短手术时间,减少术中出血量,降低术后假体失效率,促进患者术后髋关节功能的恢复,可以有效地应用于临床。,"[173, 223, 1015, 397]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +40,3,number,31,"[583, 1520, 607, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +40,4,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +41,0,header,海南医学院硕士学位论文,"[492, 85, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +41,1,paragraph_title,参考文献,"[526, 155, 665, 192]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u53c2\u8003\u6587\u732e""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +41,2,reference_content,"[1] Learmonth I D, Young C, Rorabeck C. 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It can reconstruct joint function and improve the quality of life of patients, but d","[174, 1060, 1018, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +46,6,number,37,"[583, 1520, 607, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +46,7,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +47,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +47,1,abstract,"infection, unequal length of lower limbs and other factors are still the main reasons for revision after hip joint surgery. Primary factor. Accurate prosthesis placement, excellent hip function and lo","[175, 153, 1017, 745]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True +47,2,paragraph_title,Keywords: total hip arthroplasty; preoperative planning; prosthesis type,"[175, 809, 893, 838]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Keywords: total hip arthroplasty; preoperative planning; pro""]",subsection_heading,0.6,,unknown_like,none,True,True +47,3,text,全髋关节置换术(Total hip arthroplasty,THA)是髋关节骨性关节炎、老年股骨颈骨折及股骨头坏死最常见的治疗方案之一,在全世界范围内广泛开展,被誉为20世纪最成功的手术 $ ^{[1]} $。据不完全统计,我国2018年约有40万人接受髋关节置换手术,并且将以每年20%的速度快速增长 $ ^{[2]} $。随着材料学的发展和手术技术的进步,髋关节置换术的短期与长期疗效都获得了巨,"[174, 886, 1016, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +47,4,text,THA 术前规划最主要的方式是模板测量,即术前使用髋关节 x 线片或计算机断层扫描(CT)等影像学检查,预测植入的人工关节假体大小和位置的过程 $ ^{[6]} $。模板术前测量可以帮助术者精准选择合适假体大小,同时规划股骨颈截骨高度、髋臼磨挫深度及假体安放位置。因此,术前规划和测量可有效降低术后假体松动、假体周围骨折、髋关节脱位等 THA 手术并发症的发生率。同时,精确术前,"[175, 1259, 1015, 1478]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +47,5,number,38,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +47,6,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +48,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +48,1,text,规划和测量可预测手术难度,完善围手术期器械准备,缩短手术时间,降低手术风险 $ ^{[7]} $。,"[175, 151, 1002, 227]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +48,2,paragraph_title,1. 全髋关节置换术前规划方式的进展,"[176, 297, 668, 331]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1. \u5168\u9acb\u5173\u8282\u7f6e\u6362\u672f\u524d\u89c4\u5212\u65b9\u5f0f\u7684\u8fdb\u5c55""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,True,True +48,3,text,完整的术前准备及设计对于 THA 非常重要,选用适当尺寸型号假体可得到较低的手术截骨量,重建偏心距及下肢长度、优化假体的位置,获得更大的假体稳定性,更好的症状缓解程度及关节功能,同时保证手术安全及减少费用等 $ ^{[8]} $。随着科技的进步,计算机技术,人工智能、大数据被广泛运用于医学领域,促进着医学事业的飞跃发展,手术前假体规划由原来的胶片模板、数字模板二维平面图像,发展到建模软件进行三维立,"[175, 355, 1015, 714]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +48,4,paragraph_title,1.1 二维模板测量法,"[224, 734, 506, 769]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1 \u4e8c\u7ef4\u6a21\u677f\u6d4b\u91cf\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +48,5,text,模板测量是关节置换术前计划中常规的一步,自全髋关节置换术诞生伊始,Charnley $ ^{[9]} $和Muller $ ^{[10]} $等都强调了使用术前X片进行规划的重要性。二维模板测量法主要包括胶片模板法和数字模板法。胶片模板是由器械设备公司提供的手工薄膜模板,其上印有各型号大小的假体轮廓图案,将胶片模板与患者髋关节正位片重叠,选择合适假体类型。数字模板是指用影像处理软件制作出数字化的假,"[174, 792, 1014, 1151]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +48,6,paragraph_title,1.1.1 X 线摄片,"[225, 1166, 397, 1195]",subsection_heading,0.85,"[""paragraph_title label with numbering: 1.1.1 X \u7ebf\u6444\u7247""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +48,7,text,在拍摄髋关节正位 X 线片时要求患者仰卧摄影台上,双下肢伸直,双足内旋并拢(10° -15°),源—像距离 100cm $ ^{[11]} $。标准髋关节正位片要求显示双侧骨盆,骶骨和腰椎的下部,及远端股骨至峡部水平。股骨头显示照片正中,股骨颈无投影变形,髋关节各骨纹理清晰锐利,坐骨棘清晰 $ ^{[12]} $。在拍摄 X 线片时常规放入一个带有标尺的金属球或标准硬币,拍摄完成后选用与 x 线片,"[174, 1213, 1015, 1479]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +48,8,number,39,"[583, 1520, 607, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +48,9,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +49,0,header,海南医学院硕士学位论文,"[492, 84, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +49,1,image,,"[349, 158, 885, 529]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +49,2,figure_title,图 1 髋关节摄片体位,"[517, 557, 715, 585]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 1 \u9acb\u5173\u8282\u6444\u7247\u4f53\u4f4d""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +49,3,paragraph_title,1.1.2 标记骨性解剖,"[224, 697, 452, 727]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1.2 \u6807\u8bb0\u9aa8\u6027\u89e3\u5256""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +49,4,text,骨性解剖包括下列(图 2):a、泪滴:髋臼杯下缘的骨性标记;b、髋臼上缘:髋臼杯上缘的骨性标记,可用来评估髋臼覆盖率;c、髂坐线:髂骨内缘与坐骨内缘的连线,用来评估髋臼杯放置深度;d、大转子:重建股骨旋转中心及股骨偏心距骨性标志;e、小转子:术前术后影像学评估双下肢长度的骨性标志。f、旋转中心:髋关节活动的中心,用于评估髋臼杯或股骨头假体旋转中心位置的标志(非骨性标志)。,"[175, 745, 1013, 1011]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +49,5,image,,"[455, 1022, 783, 1444]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +49,6,figure_title,图 2 髋关节骨性标志(左侧),"[478, 1463, 748, 1489]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 2 \u9acb\u5173\u8282\u9aa8\u6027\u6807\u5fd7\uff08\u5de6\u4fa7\uff09""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +49,7,number,40,"[583, 1520, 608, 1539]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +49,8,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +50,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +50,1,paragraph_title,1.1.3 假体规划,"[224, 152, 397, 181]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.1.3 \u5047\u4f53\u89c4\u5212""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +50,2,text,"充分评估患者双下肢长度差异(骨性长度差和外观长度差)、髋臼包容性、髋臼骨质情况、股骨髓腔形状、髓腔大小及股骨偏心距等。根据比例尺选用厂家透明模板进行模板规划。髋臼假体要求 $ ^{[13,14]} $:①髋臼杯下缘要求与泪滴下缘平行。②髋臼杯内侧缘距离泪滴外侧缘5—10mm,位于髂坐线上,杯外侧缘超过髋臼上缘骨质,适当保留软骨下骨,保证假体覆盖率。股骨假体要求:①根据股骨髓腔形状选择合适假体类型。","[175, 199, 1015, 557]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +50,3,text,据相关研究表明,二维模板规划精准预测髋臼假体准确率为25%—85.7%,股骨假体的准确率为32%—49.15%,预测髋臼假体在一个尺寸内的准确率为45%—89.3%,而股骨假体准确率为60.7%—83.6% $ ^{[6]} $,股骨柄的准确率略高于髋臼杯。随着科学技术的发展,各种辅助手术技术被应用在髋关节置换中。尽管有不同方式选择,由于二维规划的简便性,目前仍被广泛使用。由于髋关节是3D结构,2,"[175, 574, 1016, 1307]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +50,4,paragraph_title,1.2 三维模板测量法,"[225, 1374, 506, 1408]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2 \u4e09\u7ef4\u6a21\u677f\u6d4b\u91cf\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +50,5,text,数字化技术在医学领域已广泛应用,对 THA 也有着重要的影响,尤其是在术前规划方面,利用数字化模板进行术前测量显示出独特的优势 $ ^{[18]} $。THA 预测,"[175, 1431, 1015, 1508]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +50,6,number,41,"[583, 1522, 606, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +50,7,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +51,0,header,海南医学院硕士学位论文,"[492, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +51,1,text,的准确性提高得益于术前规划从二维到三维的转变。髋关节 x 线片由于二维投照的限制,无法反应骨盆倾斜程度、股骨前倾角、股骨颈干角、股骨前弓等信息。而三维成像很好地解决了这些问题 $ ^{[19]} $。三维模板测量法简单来说,就是将患者髋关节 CT 资料通过处理软件转化为虚拟三维模型并进行手术设计及规划。操作要求如下述:,"[175, 152, 1014, 368]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,2,paragraph_title,1.2.1 CT 扫描要求,"[224, 385, 434, 414]",subsection_heading,0.85,"[""paragraph_title label with numbering: 1.2.1 CT \u626b\u63cf\u8981\u6c42""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +51,3,text,螺旋 CT 对髋关节进行扫描,范围包括骨盆、骶尾骨、双侧股骨近端 1/2,如患者出现股骨畸形、脊柱侧弯或骨盆倾斜等情况,可以适当扩大 CT 扫描范围。目前三维规划软件对扫面层厚要求不一,一般选择 1mm 层厚。完成髋关节 CT 后,将患者数据以 DICOM 格式保存备用。,"[177, 433, 1015, 604]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,4,paragraph_title,1.2.2 三维规划软件分类,"[224, 620, 501, 649]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2.2 \u4e09\u7ef4\u89c4\u5212\u8f6f\u4ef6\u5206\u7c7b""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +51,5,text,目前用于手术规划的处理软件主要分为三类:第一,商业软件,如比利时materialise开发的MIMICS系统使用较为广泛、功能相对全面 $ ^{[20]} $,同时在图像解剖分析和创建精准的数字化3D模型的基础上还能规划手术过程。第二,其他软件,如Analyze、3D-DOCTOR、SimPlant和SurgiCase等,这些软件主要用于处理图像数据、3D分析、设计或进行3D模型的打印 $ ^{[,"[174, 667, 1015, 1025]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,6,paragraph_title,1.2.3 三维规划过程,"[224, 1041, 446, 1070]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2.3 \u4e09\u7ef4\u89c4\u5212\u8fc7\u7a0b""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +51,7,text,将患者的 DICOM 格式数据将其导入规划软件行三维重建。同时在计算机中进行髋关节三维动态重建,了解髋关节损伤及分型。在三维模型上标定髋关节相应识别点。在此模型的基础上根据术者的计划进行截骨、假体放置等数字化模拟步骤,根据其模拟结果选定合适尺寸的假体 $ ^{[24]} $。,"[175, 1088, 1013, 1259]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,8,text,目前,国内外在三维规划上已经有相当的应用并取得了一定的研究结果,结果均显示三维模板规划优于二维模板。M. Viceconti $ ^{[25]} $等研究发现,使用 Hip-OP三维模板系统后,将二维模板法的髋臼杯和股骨柄的准确度从83%与69%提升至86%与93%。Sugano $ ^{[26]} $等人也提示了,当股骨颈前倾和髋关节外旋超过15°,二维规划无法满足THA的术前规划,并且三维规划,"[175, 1275, 1014, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +51,9,number,42,"[583, 1521, 607, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +51,10,footer,中国知网 https://www.cnki.net,"[38, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +52,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +52,1,text,二维规划。但 Jurik $ ^{[27]} $等提出,单次螺旋 CT 扫描相当于进行 4 次髋关节 X 线片,他们对辐射量表示担忧。除此之外,Habeeb $ ^{[28]} $等也发现,三维规划与相关成本较高可能会阻碍三维规划的推广,但他们认为,与 2D 模板相比,3D 模板能更精准的规划 THA。并且,同时还证明 3D 模板方式具有足够的可靠性和可重复性。因此,三维模板临床上的可使用性需要进,"[175, 151, 1014, 370]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,2,paragraph_title,1.3 人工智能规划,"[225, 437, 475, 472]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.3 \u4eba\u5de5\u667a\u80fd\u89c4\u5212""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +52,3,text,近年来人工智能在生物医学研究和临床实践中发挥着越来越大的作用,在风险建模、个性化筛查、疾病诊断以及治疗效应的预测和预后等方面都显示了巨大的潜在应用价值 $ ^{[29]} $。人工智能是用计算机控制机器模拟类似人类的智能过程,它包括信息、推理和自我纠正能力,它可以帮助外科医生提供有效的治疗和个性化的体验 $ ^{[30]} $。人工智能可以分析通过各种放射技术获得的数字形式的数据,如 X 线照片、,"[174, 495, 1015, 807]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,4,text,随着人工智能技术的发展,运用 AI 技术进行髋关节疾病识别及诊断,髋部骨骼的三维成像,智能规划手术方案变得可行。吴东 $ ^{[31]} $等验证了 AI-HIP 系统(北京长木古有限公司)的有效性及准确性。丁冉 $ ^{[32]} $等对 32 例行初次全髋关节置换患者接受传统模板与人工智能术前规划方式进行比较发现,人工智能不仅假体大小及位置规划准确度优于传统模板组,而且规划时间明显短于传统模板,"[174, 823, 1015, 1089]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,5,paragraph_title,1.4 手术机器人,"[224, 1155, 445, 1190]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.4 \u624b\u672f\u673a\u5668\u4eba""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +52,6,text,"工业中,机器人技术是一种完善的优化流程和提高质量的方法。在关节外科领域,特别是全髋关节置换术中使用机器人的想法起源于20世纪90年代初的美国。1992年至1993年,ROBODOC手术机器人(Integrated Surgical Systems, Davis, California)经美国食品和药物管理局授权用于患者。1994年,这台机器人就已经在德国进行了4500多台髋关节置换术 $ ^{[3","[175, 1213, 1015, 1478]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +52,7,number,43,"[583, 1521, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +52,8,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +53,0,header,海南医学院硕士学位论文,"[491, 85, 698, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +53,1,text,天玑(北京)以及和华(北京)等。,"[175, 151, 557, 181]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,short_fragment,False,True +53,2,text,机器人手术的关键仍然是术前规划,通过术前导入患者髋关节 CT 数据,虚拟形成髋关节 3D 模型,结合解剖数据和患者特定骨盆的参考点,并且在手术前进行视野验证 $ ^{[34]} $。机器人的规划软件为每个截骨面生成切割边界,每个边界由切割平面和切割平面与骨表面相交的二维轮廓组成。确保了机器人只能切割骨头,并防止其损伤周围的软组织。术中,医生通过特殊的标记导针标记相应的骨结构,机器人自动生成截骨平面,"[175, 199, 1015, 558]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +53,3,text,随着科技的进步,机器人在髋关节手术中的应用效果值得肯定,但这项技术也存在一些局限性。使用的主要限制与其成本效益与工程师依赖性相关。患者层面上来说,与可靠疗效相关的高额手术费用及使用费用增加了治疗负担。另外,在复杂髋关节或者发育异常的髋关节中,机器人无法精准识别髋关节骨性标志,将会直接影响髋臼假体位置的准确性 $ ^{[37]} $。,"[174, 573, 1014, 792]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +53,4,paragraph_title,2 总结与展望,"[223, 858, 408, 893]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2 \u603b\u7ed3\u4e0e\u5c55\u671b""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,True,True +53,5,text,术前规划由原来二维胶片向二维数字发展,到各类三维软件开发,然后到3D打印快速成型技术进行实物打印,使手术前的计划由二维变为三维,由平面走向立体,由静态走向动态。目前在骨科领域已经广泛应用于手术方案制定、个性化假体选择以及术后疗效观察等方面,并逐步向个体化方向转变。这样就便于骨科医生对形变复杂髋关节局部解剖及空间关系有一个直观认识,开展较全面术前评估,设计更为精准的术前计划,实践手术过程,最后获得了,"[174, 915, 1016, 1463]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +53,6,number,44,"[582, 1521, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +53,7,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1650]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +54,0,header,海南医学院硕士学位论文,"[492, 85, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +54,1,paragraph_title,综述参考文献,"[493, 155, 696, 192]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u7efc\u8ff0\u53c2\u8003\u6587\u732e""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +54,2,reference_content,"[1]Bou M J, Parekh A, Osmani F, et al. Failed Total Hip Arthroplasty[J]. JBJS Rev, 2018,6(11):e3.","[191, 215, 1011, 289]",reference_item,0.85,"[""reference content label: [1]Bou M J, Parekh A, Osmani F, et al. Failed Total Hip Arth""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +54,3,reference_content,"[2]边焱焱, 程开源, 常晓, 等. 2011 至 2019 年中国人工髋膝关节置换手术量的初步统计与分析[J]. 中华骨科杂志, 2020(21): 1453-1460.","[191, 308, 1011, 385]",reference_item,0.85,"[""reference content label: [2]\u8fb9\u7131\u7131, \u7a0b\u5f00\u6e90, \u5e38\u6653, \u7b49. 2011 \u81f3 2019 \u5e74\u4e2d\u56fd\u4eba\u5de5\u9acb\u819d\u5173\u8282\u7f6e\u6362\u624b\u672f\u91cf\u7684\u521d\u6b65\u7edf\u8ba1\u4e0e\u5206\u6790[J]. \u4e2d""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +54,4,reference_content,"[3]Hu C Y, Yoon T R. Recent updates for biomaterials used in total hip arthroplasty[J]. 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Primary and revision total hip replacement using the Robodoc system[J]. Clin Orthop Relat Res, 1998(354):82-91.","[180, 1182, 1011, 1259]",reference_item,0.85,"[""reference content label: [33]Bargar W L, Bauer A, Borner M. Primary and revision tota""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +56,11,reference_content,"[34]Schneider J, Kalender W. Geometric accuracy in robot-assisted total hip replacement surgery[J]. Comput Aided Surg, 2003,8(3):135-145.","[180, 1276, 1010, 1352]",reference_item,0.85,"[""reference content label: [34]Schneider J, Kalender W. Geometric accuracy in robot-ass""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +56,12,reference_content,"[35] Jakopec M, Harris S J, Rodriguez Y B F, et al. The first clinical application of a ""hands-on"" robotic knee surgery system[J]. Comput Aided Surg, 2001, 6(6): 329-339.","[180, 1370, 1011, 1489]",reference_item,0.85,"[""reference content label: [35] Jakopec M, Harris S J, Rodriguez Y B F, et al. The firs""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +56,13,number,47,"[583, 1520, 608, 1538]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +56,14,footer,中国知网 https://www.cnki.net,"[37, 1621, 384, 1651]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +57,0,header,海南医学院硕士学位论文,"[492, 86, 697, 108]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +57,1,reference_content,"[36]Lecoanet P, Pascal G, Khaddad A, et al. Robot-assisted continent urinary diversion according to the Mitrofanoff principle: results of a bicentric study[J]. World J Urol, 2021,39(6):2073-2079.","[180, 155, 1011, 272]",reference_item,0.85,"[""reference content label: [36]Lecoanet P, Pascal G, Khaddad A, et al. 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The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathw","[65, 825, 301, 1062]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Liu, H.-Y.; Chang, C.-F.; Lu, C.-C.; Wu, S.-C.; Hu""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,8,text,Academic Editor: Wataru Ariyoshi,"[68, 1076, 290, 1097]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic Editor: Wataru Ariyoshi""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,9,text,"Received: 4 April 2022 +Accepted: 17 June 2022 +Published: 22 June 2022","[67, 1114, 223, 1183]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 4 April 2022\nAccepted: 17 June 2022\nPublished: 22 ""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,10,text,Publisher's Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[66, 1197, 308, 1290]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +1,11,image,,"[69, 1313, 185, 1354]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,12,text,"Copyright: © 2022 by the authors. +Licensee MDPI, Basel, Switzerland. +This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66, 1363, 309, 1551]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2022 by the authors.\nLicensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,13,text,"1 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; +artherb02@gmail.com (H.-Y.L.); cclu0880330@gmail.com (C.-C.L.); shunchengwu@hotmail.com (S.-C","[326, 479, 1123, 566]",affiliation,0.8,"[""page-1 zone affiliation_zone: 1 Orthopaedic Research Center, College of Medicine, Kaohsiun""]",affiliation,0.8,body_zone,reference_like,reference_numeric_dot,True,True +1,14,text,"2 Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; ycwang.ow@gmail.com","[326, 565, 1075, 608]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2 Department of Orthopedics, Kaohsiung Medical University Ho""]",affiliation,0.8,body_zone,reference_like,reference_numeric_dot,True,True +1,15,text,"3 Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","[327, 608, 999, 651]",affiliation,0.8,"[""page-1 zone affiliation_zone: 3 Regeneration Medicine and Cell Therapy Research Center, Ka""]",affiliation,0.8,body_zone,reference_like,reference_numeric_dot,True,True +1,16,text,"4 Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan +5 Department of Anatomy, School of Medicine, China Medical University, Taichung 40402, Taiwan;","[327, 652, 1117, 715]",affiliation,0.8,"[""page-1 zone affiliation_zone: 4 Department of Orthopedics, College of Medicine, Kaohsiung ""]",affiliation,0.8,body_zone,reference_like,reference_numeric_dot,True,True +1,17,text,"Department of Orthopedics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Ta 7 +Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University,","[325, 719, 981, 781]",affiliation,0.8,"[""page-1 zone affiliation_zone: Department of Orthopedics, Kaohsiung Municipal Siaogang Hosp""]",affiliation,0.8,body_zone,body_like,none,True,True +1,18,text,"8 Lef +9 Graduate +Kaohsiung 80706,","[327, 785, 1108, 844]",section_heading,0.65,"[""numbered text block: 8 Lef\n9 Graduate\nKaohsiung 80706,""]",section_heading,0.65,body_zone,reference_like,reference_numeric_dot,True,True +1,19,text," $ ^{10} $ Department of Bioscience Technology, Chang Jung Christian University, Tainan 71101, Taiwan; mjlee@mail.cjcu.edu.tw","[327, 846, 1034, 890]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{10} $ Department of Bioscience Technology, Chang Jung Ch""]",affiliation,0.8,body_zone,body_like,affiliation_marker,True,True +1,20,text," $ ^{11} $ Innovative Research Center of Medicine, Chang Jung Christian University, Iainan 71101, Taiwan","[328, 888, 1044, 911]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{11} $ Innovative Research Center of Medicine, Chang Jung""]",affiliation,0.8,body_zone,body_like,affiliation_marker,True,True +1,21,text," $ ^{12} $ Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan; cdyang@mail.npust.edu.tw","[325, 909, 972, 970]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{12} $ Graduate Institute of Animal Vaccine Technology, C""]",affiliation,0.8,body_zone,body_like,affiliation_marker,True,True +1,22,text,"Ph.D. Program in Biomedical Engineering, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","[327, 974, 1036, 1016]",affiliation,0.8,"[""page-1 zone affiliation_zone: Ph.D. Program in Biomedical Engineering, College of Medicine""]",affiliation,0.8,body_zone,body_like,none,True,True +1,23,text," $ ^{14} $ Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan","[327, 1017, 1038, 1040]",frontmatter_noise,0.85,"[""affiliation block: $ ^{14} $ Department of Orthopedics, Kaohsiung Municipal Ta-""]",frontmatter_noise,0.85,body_zone,body_like,affiliation_marker,False,False +1,24,text," $ ^{15} $ Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 80708, Taiwan","[327, 1039, 1065, 1081]",frontmatter_noise,0.85,"[""affiliation block: $ ^{15} $ Department of Healthcare Administration and Medica""]",frontmatter_noise,0.85,body_zone,body_like,affiliation_marker,False,False +1,25,text,"16 Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan","[327, 1082, 1119, 1129]",frontmatter_noise,0.7,"[""keyword-like block: 16 Department of Obstetrics and Gynecology, National Cheng K""]",frontmatter_noise,0.7,body_zone,reference_like,reference_numeric_dot,False,False +1,26,text," $ ^{17} $ Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80420, Taiwan + $ ^{18} $ Graduate Institute of Materials Engineering, College of Engineering, Natio","[327, 1129, 1120, 1190]",frontmatter_noise,0.85,"[""affiliation block: $ ^{17} $ Institute of Medical Science and Technology, Natio""]",frontmatter_noise,0.85,body_zone,body_like,affiliation_marker,False,False +1,27,text,Correspondence: cwwei@gap.kmu.edu.tw (C.-W.W.); kanglin@mail.ncku.edu.tw (L.K.); hwan@kmu.edu.tw (C.-H.C.); Tel.: +886-7-3121101 (ext. 2648#19) (C.-W.W.); +886-6-2766685 (L.K.); +886-7-3209209 (C.-H.C,"[325, 1192, 1057, 1254]",frontmatter_support,0.75,"[""page-1 correspondence support: Correspondence: cwwei@gap.kmu.edu.tw (C.-W.W.); kanglin@mail""]",frontmatter_support,0.75,body_zone,body_like,none,True,True +1,28,text,† These authors contributed equally to this work.,"[329, 1256, 699, 1278]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u2020 These authors contributed equally to this work.""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,29,abstract,"Abstract: Osteoarthritis (OA) is the most common joint disease characterized by degeneration of articular cartilage and causes severe joint pain, physical disability, and impaired quality of life. Rec","[324, 1305, 1125, 1539]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,30,footer,"Biomedicines 2022, 10, 1477. https://doi.org/10.3390/biomedicines10071477","[67, 1625, 606, 1647]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,31,footer,https://www.mdpi.com/journal/biomedicines,"[777, 1625, 1122, 1648]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 258, 132]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,number,2 of 25,"[1068, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,2,abstract,"In this review, we first focus on the importance of mitochondria metabolic dysregulation related to OA. Then, we show recent evidence on the AMPK-SIRT mediated pathway associated with OA pathogenesis ","[327, 193, 1123, 297]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +2,3,text,Keywords: osteoarthritis; mitochondria; AMP-activated protein kinase (AMPK); sirtuins (SIRT); long non-coding RNA (lncRNA); microRNA (miRNA),"[327, 320, 1122, 370]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,paragraph_title,1. Introduction,"[328, 447, 473, 469]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,frontmatter_side_zone,heading_like,heading_numbered,True,True +2,5,text,"Osteoarthritis (OA) is a degenerative and debilitating joint disease associated with the symptoms and signs of joint pain, swelling, stiffness, mobility limitation, and joint deformity [1]. According ","[324, 476, 1125, 929]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"Mitochondria are double-membrane organelles that convert organic molecules (e.g., glucose, amino acids, and fatty acids) into adenosine triphosphate (ATP) via the electron transport chain (ETC) and ox","[325, 929, 1126, 1306]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"In addition, recent studies have shown that the AMP-activated protein kinase (AMPK) and sirtuin (SIRT) pathways are important for signal transduction to regulate mitochondrial physiological function. ","[325, 1306, 1125, 1558]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"Biomedicines 2022, 10, 1477","[67, 111, 259, 131]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,3 of 25,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,2,text,"Therefore, in this review, we first discuss how mitochondrial metabolism dysfunction can lead to OA pathogenesis. Then, we unravel the AMPK-SIRT pathway, lncRNA, and microRNA in association with OA pa","[324, 192, 1125, 269]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,2. Mitochondrial Metabolism Dysfunction to OA Pathogenesis,"[326, 288, 909, 311]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Mitochondrial Metabolism Dysfunction to OA Pathogenesis""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +3,4,text,Mitochondria are known to be dynamic and complex organelles responsible for numerous physiological processes in chondrocytes related to energy production and cell growth and proliferation. Recent stud,"[324, 319, 1127, 698]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,image,,"[334, 723, 1086, 1140]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,Figure 1. The diagram shows the AMPK–SIRT signaling pathways related to OA pathogenesis and the potential treatment options for OA targeting at mitochondrial pathways. The outer circle is the cell mem,"[324, 1161, 1124, 1494]",figure_caption,0.92,"[""figure_title label: Figure 1. The diagram shows the AMPK\u2013SIRT signaling pathways""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,7,text,"In addition to AMPK-SIRT regulation, recent studies have yielded evidence on the interaction between lncRNA and miRNA in relation to OA pathogenesis. LncRNA, which","[327, 1511, 1123, 1561]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"Biomedicines 2022, 10, 1477","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,4 of 25,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,2,text,"binds to miRNAs to inhibit their combining with downstream genes, is crucial for metabolic reactions and homeostasis of articular chondrocytes [27]. Together with miRNA, it focuses on promoting or inh","[324, 192, 1125, 395]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,2.1. Mitochondrial Respiratory Chain (MRC) in Osteoarthritis,"[327, 412, 846, 436]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Mitochondrial Respiratory Chain (MRC) in Osteoarthritis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,4,text,"The mitochondrial membrane potential is generated by proton pumps (Complexes I, III, and IV), which are located on the inner membrane and generate transmembrane potential energy in the form of hydroge","[324, 443, 1125, 669]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"However, in OA cartilage, due to degradation (thinning, micro-cracks, and even disappearance), chondrocytes in the deep zone receive more oxygen stimulation. In a relatively high oxygen concentration ","[324, 669, 1126, 1022]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"Currently, the standard evaluation of mitochondrial function is the analysis of respiratory chain enzyme complexes, citrate synthase (CS), and changes in mitochondrial membrane potential ( $ \Delta\Ps","[323, 1022, 1125, 1322]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"Recent studies have reported that mitochondria are critical mechanotransducers, which connect the extracellular mechanical signals with intracellular signaling pathways $ [43,44] $. Bartell et al. re","[326, 1323, 1125, 1526]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,"Biomedicines 2022, 10, 1477","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,5 of 25,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,2,paragraph_title,2.2. Reactive Oxygen Species (ROS) in Osteoarthritis,"[327, 192, 772, 217]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Reactive Oxygen Species (ROS) in Osteoarthritis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,3,text,"ROS are free radicals formed by the normal cellular metabolism of oxygen. The main ROS produced by chondrocytes are nitric oxide (NO), superoxide anion ( $ O^{2-} $), and their derivative radicals, in","[324, 223, 1124, 598]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"On the other hand, the non-mitochondrial pathway mainly refers to nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Some studies showed that in pathological conditions, including mechanical","[326, 599, 1124, 826]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,"Oxidative stress damage may contribute to chronic and persistent mitochondrial dysfunction because overproduction of ROS impairs mitochondrial respiration, which further increases ROS production, thus","[326, 826, 1125, 1127]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,"On the other hand, antioxidant systems balance the production and elimination of ROS. These systems, the first line of defense, consist of enzymatic and non-enzymatic antioxidants, including glutathio","[326, 1128, 1125, 1504]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,"The contents in Table 1 represent the mechanism and biological functions of traditionally potential drugs in OA. The metabolic effects of these drugs include reduction in ROS,","[327, 1503, 1126, 1555]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,0,header,"Biomedicines 2022, 10, 1477","[67, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,6 of 25,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,2,text,"inhibition of ECM degradation, reduced inflammatory responses, and apoptosis inhibition. On the other hand, the contents in Table 2 represent the classification and biological functions of polyphenol,","[325, 192, 1125, 366]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,3,text,"Some research into drugs that target ROS production is shown in Tables 1 and 2. Hosseinzadeh, A. et al. reported that diallyl disulfide (DADS), which has antioxidant and anti-inflammatory properties, ","[324, 367, 1126, 721]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,figure_title,Table 1. Classifications and biological functions of drugs in osteoarthritis.,"[326, 744, 919, 768]",table_caption,0.9,"[""table prefix matched: Table 1. Classifications and biological functions of drugs i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,5,table,
项目得分项目得分
Ⅰ、疼痛2、功能活动
(44)(1)上楼梯
轻微(40)
DrugsMechanismFunctionRef.
DADSIncrease Nrf2 nuclear translocation and gene expressions of antioxidant enzymesReduce the pr,"[68, 782, 1123, 1376]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +7,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 259, 131]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,7 of 25,"[1068, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,2,figure_title,Table 2. Classifications and biological functions of polyphenol in osteoarthritis.,"[326, 192, 963, 215]",table_caption,0.9,"[""table prefix matched: Table 2. Classifications and biological functions of polyphe""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +7,3,table,"
DrugsMechanismFunctionRef.
EGCGDecrease the expressions of mTORReduce the chondrocyte apoptosis and activate au","[69, 230, 1117, 690]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +7,4,paragraph_title,2.3. Chondrocyte Senescence and Mitochondrial Autophagy in Osteoarthritis,"[327, 722, 959, 746]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Chondrocyte Senescence and Mitochondrial Autophagy in O""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,5,text,"Recent research showed that cell studies and animal models point to aging-related and stress-induced oxidative stress as important factors related to chondrocyte senescence [82–84]. Senescent cells, w","[325, 752, 1125, 1206]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Autophagy is a cellular process regarded as a mechanism for cell survival when cells become stressed, degrading dysfunctional proteins and macromolecules, and then recycling them to produce materials ","[324, 1206, 1126, 1560]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 258, 131]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 25,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,text,"treatment, Huang, H. T. et al. showed that $ (-) $-Epigallocatechin 3-gallate (EGCG), the most plentiful bioactive polyphenol of green tea with anti-arthritic, anti-inflammatory, and antioxidant effe","[326, 192, 1124, 369]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,paragraph_title,2.4. Chondrocyte Apoptosis and Calcium Homeostasis Regulation in Osteoarthritis,"[327, 387, 1008, 412]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Chondrocyte Apoptosis and Calcium Homeostasis Regulatio""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,4,text,Apoptosis is the most common form of cell death. It is characterized by a series of morphological and biochemical changes that lead to the formation of apoptotic bodies that are phagocytosed by macrop,"[325, 418, 1124, 771]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"There are a large number of apoptotic chondrocytes in OA cartilage, and mitochondrial-induced chondrocytes apoptosis is mediated by the reduction in $ \Delta\Psi_{m} $, overexpression of ROS, mechani","[326, 770, 1124, 1097]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"The calcium ion (Ca²⁺), one of the most important intracellular second messengers, is responsible for biological functions, such as cell adhesion, metabolism, secretion, proliferation, and apoptosis [","[325, 1097, 1125, 1423]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,text,"Under physiological cell stress, mitochondria can take up $ Ca^{2+} $ from cytosolic $ Ca^{2+} $ or the ER, and store it transiently to maintain homeostasis and regulate mitochondrial function [105,","[325, 1422, 1125, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 258, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,9 of 25,"[1069, 111, 1121, 131]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,text,and begin to shape $ Ca^{2+} $ dynamics [105]. Huser and Davies showed that impact-induced chondrocyte apoptosis and mitochondrial depolarization were significantly decreased when the amount of calci,"[326, 191, 1124, 443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"Several studies are concerned with drugs that focus on the mitochondrial apoptotic pathway, and these are listed in Tables 1 and 2. Shao, X. et al. showed that a lower range of the molecular weight of","[324, 442, 1125, 898]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,paragraph_title,2.5. mtDNA Haplogroups in Osteoarthritis,"[328, 914, 689, 939]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.5. mtDNA Haplogroups in Osteoarthritis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,5,text,"Mitochondria, which is well known as “maternal inheritance”, have their own genomic DNA [116]. Mitochondrial DNA (mtDNA) encodes 13 polypeptide subunits essential for the OXPHOS process, 2 ribosomal R","[326, 946, 1125, 1247]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,text,"In recent studies, European mtDNA haplogroup J was notably correlated with a decreased risk of knee OA in Spain [122,123], and individuals from the United Kingdom (UK) carrying the haplogroup T showed","[325, 1248, 1126, 1550]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"Biomedicines 2022, 10, 1477","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,10 of 25,"[1062, 111, 1121, 131]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,text,"There are different viewpoints to explain the associations between mtDNA haplogroups and OA. First, the associations could reside in the subtle functional differences between haplogroups, which eventu","[324, 192, 1125, 596]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,paragraph_title,3. AMPK and SIRT Pathway in Related to OA Pathogenesis,"[327, 613, 879, 637]",section_heading,0.85,"[""paragraph_title label with numbering: 3. AMPK and SIRT Pathway in Related to OA Pathogenesis""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +10,4,text,AMP-activated protein kinase (AMPK) and sirtuins (SIRT) are important biosensors that are activated in response to high AMP/ATP and ADP/ATP ratios [134]. AMPK activation restores ATP levels by inhibit,"[325, 645, 1125, 947]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"Sirtuins, which are a family of highly conserved protein modifying enzymes, detect fluctuations in the $ NAD^{+}/NADH $ ratio and regulate mitochondrial physiology and cell metabolism [140]. There ar","[325, 947, 1125, 1121]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"As mentioned above, AMPK and SIRT together regulate a variety of cellular physical activities. Here, we summarize the mechanism of action of AMPK and SIRT on ECM production, mitochondrial biogenesis, ","[324, 1122, 1125, 1298]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,paragraph_title,3.1. AMPK and SIRT Regulate ECM (Extracellular Matrix) Production and Mitochondrial Biogenesis in Chondrocytes,"[327, 1316, 1075, 1363]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. AMPK and SIRT Regulate ECM (Extracellular Matrix) Produ""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,8,text,"AMPK activation can increase ATP generation, which is beneficial for synthesizing ECM components. Some studies reported that physiological dynamic compression loading alters central metabolism in chon","[325, 1369, 1125, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,number,11 of 25,"[1062, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,text,"AMPK and SIRT regulate mitochondrial biosynthesis in chondrocytes via the AMPK-SIRT1/SIRT3-PCG-1α (peroxisome proliferator-activated receptor-γ coactivator 1 alpha) signaling pathway [147,148]. Wang e","[325, 192, 1125, 443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,3,text,"PGC-1α is a coactivator with nuclear respiratory factors (NRFs) in transcription and regulates the mitochondrial transcription factor A (TFAM), which is responsible for the mtDNA duplication, mitochon","[324, 444, 1125, 794]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"Some studies that focus on drugs targeting AMPK–SIRT pathways related to ECM production and mitochondrial biogenesis are shown in Tables 1 and 2. Dihydromyricetin (DHM), which has anti-inflammation an","[324, 794, 1126, 1175]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,paragraph_title,3.2. AMPK and SIRT Regulate Autophagy and Mitophagy in Chondrocytes,"[328, 1192, 950, 1216]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. AMPK and SIRT Regulate Autophagy and Mitophagy in Chond""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +11,6,text,"Autophagy is a conserved intracellular process that delivers cytoplasmic elements (e.g., proteins, organelles, and pathogens) to lysosomes for degradation via double-membrane autophagosomes [158]. On ","[325, 1223, 1124, 1347]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"Some studies reported that AMPK activates autophagy and mitophagy to remove damaged or defective mitochondria with impaired OXPHOS, whereas mTORC1, the mechanistic target of rapamycin complex 1, block","[326, 1348, 1125, 1551]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,0,header,"Biomedicines 2022, 10, 1477","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,12 of 25,"[1062, 111, 1121, 132]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,text,"TSC2 and the mTORC1 subunit RAPTOR, which results in reducing mTOR activity under conditions of energy stress and inhibiting the phosphorylation on ULK1 that activates autophagy [160,161]. Moreover, E","[324, 191, 1124, 419]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,text,"AMPK also directly regulates downstream mitophagy in chondrocytes via the SIRT1/SIRT3-FoxO3A-PINK1/Parkin signaling pathway, which is involved in clearing damaged mitochondria, limiting ROS production","[324, 417, 1125, 897]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,"Recent research has also reported that autophagy declines with age, which further leads to chondrocyte dysfunction and OA progression. Some studies have indicated that basal autophagy decreases with a","[325, 896, 1125, 1070]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"There are some potential drugs that focus on the AMPK–SIRT pathways related to mitophagy in OA chondrocytes, and these are shown in Tables 1 and 2. Huang, L. W. reported that zinc treatment ameliorate","[324, 1071, 1125, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,0,header,"Biomedicines 2022, 10, 1477","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,header,13 of 25,"[1062, 111, 1121, 131]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,2,paragraph_title,3.3. AMPK and SIRT Regulate Oxidative Stress and Inflammation Inhibition in Chondrocytes,"[326, 192, 1100, 217]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. AMPK and SIRT Regulate Oxidative Stress and Inflammatio""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +13,3,text,"There is increasing evidence suggesting that AMPK and SIRT may be redox-sensing proteins in the management of ROS levels [135,174]. Some studies have indicated that AMPK and SIRT regulate chondrocyte ","[324, 223, 1125, 675]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"Apart from regulating oxidative stress, some studies also showed that AMPK and SIRT inhibit inflammation [70,140]. Salminen, A. and Kaarniranta, K. reported that inhibition of NF- $ \kappa $B signalin","[324, 676, 1124, 926]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,text,"Several research works discussed the drugs that focus on the AMPK–SIRT pathways related to oxidative stress regulation and inflammation inhibition in OA chondrocytes, as shown in Tables 1 and 2. Liu J","[325, 927, 1125, 1328]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,6,paragraph_title,4. Long Non-Coding RNA (lncRNA) and MicroRNA (miRNA) in Related to OA Pathogenesis,"[327, 1347, 1024, 1393]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Long Non-Coding RNA (lncRNA) and MicroRNA (miRNA) in Rela""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +13,7,text,"The human genome is estimated to consist of around 2% protein-coding RNA (pcRNA); however, the majority of the genome consists of non-coding RNA (ncRNA) [185]. The most common are tRNA, and rRNA, whic","[324, 1399, 1126, 1553]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 258, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,1,number,14 of 25,"[1062, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +14,2,text,"ogy, researchers have gradually discovered the important roles of long non-coding RNA (lncRNA) and MicroRNA (miRNA). Both lncRNA and miRNA are involved in important pathways related to OA pathogenesis","[325, 191, 1124, 294]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,3,paragraph_title,4.1. Relationship between lncRNA and OA Pathogenesis,"[327, 312, 796, 337]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.1. Relationship between lncRNA and OA Pathogenesis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +14,4,text,"LncRNA is an ncRNA that transcribes more than 200 nucleotides in length and modulates mRNA stability [188]. Previous studies have reported that, compared with healthy cartilage tissue, the expression ","[325, 344, 1126, 570]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,text,"Previous studies have shown that HOTAIR, which serves important for cancer progression, is expressed in normal human cartilage [190,191]. Research has also reported that HOTAIR and alpha-1, 2 fucosylt","[325, 570, 1125, 844]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,"MALAT1 is expressed in many tissues and participates in numerous biological processes $ [196] $. Zhang, Y. et al. reported that MALAT1 levels in OA cartilage were upregulated with AKT3 compared with ","[325, 846, 1125, 1146]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,text,"Regarding other lncRNAs involved in OA pathogenesis, Song, J. et al. reported that upregulated GAS5 levels in OA chondrocytes negatively regulated miR-21, which increased the expression of MMPs, stimu","[325, 1147, 1127, 1550]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,number,15 of 25,"[1061, 111, 1122, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +15,2,figure_title,Table 3. Classifications and biological functions of lncRNAs in osteoarthritis.,"[326, 192, 944, 215]",table_caption,0.9,"[""table prefix matched: Table 3. Classifications and biological functions of lncRNAs""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +15,3,table,"
lncRNATarget/Signaling PathwayFunctionRef.
HOTAIRFUT2/Wnt/ $ \beta $-cateninIncrease ECM degradation, chondrocy","[68, 230, 1117, 627]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +15,4,paragraph_title,4.2. Relationship between miRNA and OA Pathogenesis,"[327, 658, 791, 682]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2. Relationship between miRNA and OA Pathogenesis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +15,5,text,"In the pathogenesis of OA, miRNA has certain biological functions that mediate ECM metabolism, chondrocyte proliferation and apoptosis, and inflammatory responses. These are shown in Table 4 [208,209]","[324, 688, 1125, 1016]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,6,text,"Chondrocyte proliferation and apoptosis play a key role in OA pathogenesis, and many miRNAs regulate these important pathways. Research has demonstrated that miR-146a targets Smad4 to promote chondroc","[325, 1015, 1126, 1241]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,7,text,"Regarding the inflammatory response, previous studies revealed that several miRNAs are involved in inflammation regulation. Jones, S. revealed that miR-146, which is downregulated in OA cartilage, red","[326, 1241, 1127, 1492]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 259, 131]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,1,number,16 of 25,"[1062, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +16,2,figure_title,Table 4. Classifications and biological functions of mi-RNAs in osteoarthritis.,"[326, 192, 947, 215]",table_caption,0.9,"[""table prefix matched: Table 4. Classifications and biological functions of mi-RNAs""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +16,3,table,"
mi-RNATarget/Signaling PathwayFunctionRef.
miR-483-5pMatn3Promote ECM degradation and chondrocyte h","[332, 228, 1118, 598]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +16,4,paragraph_title,5. Conclusions,"[328, 628, 471, 651]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +16,5,text,"In this review, we first presented evidence that mitochondria not only function as “energy powerhouses”, but also regulate several physiological activities of chondrocytes, including oxidative stress,","[323, 658, 1126, 1087]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,text,"Author Contributions: Conceptualization, H.-Y.L., C.-F.C., C.-C.L., S.-C.W., B.H., C.-W.W., L.K. and C.-H.C.; methodology, H.-Y.L., C.-F.C., C.-C.L., S.-C.W., B.H., T.-L.C., S.-Y.L., C.-J.H. and M.-J.","[325, 1108, 1126, 1321]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,support_like,none,True,True +16,7,text,"Funding: This study was supported in part by the National Health Research Institute (NHRI-EX101-9935EI) of Taiwan, Kaohsiung Medical University (NPUST-KMU-109-P002, NCTUKMU108-BIO-04, KMU-TC108A02-1, ","[325, 1331, 1125, 1522]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,0,header,"Biomedicines 2022, 10, 1477","[68, 111, 258, 131]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,1,number,17 of 25,"[1062, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +17,2,text,"Acknowledgments: We appreciate the support from members of our orthopedic research center and the Department of Physiology, Kaohsiung Medical University, Kaohsiung City, Taiwan.","[326, 193, 1122, 241]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,3,text,"Conflicts of Interest: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the ma","[326, 251, 1123, 322]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +17,4,paragraph_title,References,"[68, 342, 176, 365]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +17,5,reference_content,"1. He, Y.; Wu, Z.; Xu, L.; Xu, K.; Chen, Z.; Ran, J.; Wu, L. The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis. Cell. Mol. Life Sci. 2020, 77, 3729–3743. [CrossRef] [PubMed]","[67, 372, 1123, 418]",reference_item,0.85,"[""reference content label: 1. He, Y.; Wu, Z.; Xu, L.; Xu, K.; Chen, Z.; Ran, J.; Wu, L.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,6,reference_content,"2. Glyn-Jones, S. Osteoarthritis. Lancet 2015, 386, 376–387. [CrossRef]","[66, 419, 644, 441]",reference_item,0.85,"[""reference content label: 2. Glyn-Jones, S. Osteoarthritis. Lancet 2015, 386, 376\u2013387.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,7,reference_content,"3. Hootman, J.M.; Helmick, C.G.; Barbour, K.E.; Theis, K.A.; Boring, M.A. Updated Projected Prevalence of Self-Reported Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation Among ","[67, 442, 1123, 508]",reference_item,0.85,"[""reference content label: 3. Hootman, J.M.; Helmick, C.G.; Barbour, K.E.; Theis, K.A.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +17,8,reference_content,"4. 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LncRNA F""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,18,reference_content,"207. Cao, L.; Wang, Y.; Wang, Q.; Huang, J. LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression. Biomed. Pharmacother. ","[67, 1022, 1120, 1066]",reference_item,0.85,"[""reference content label: 207. Cao, L.; Wang, Y.; Wang, Q.; Huang, J. LncRNA FOXD2-AS1""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,19,reference_content,"208. Malemud, C.J. MicroRNAs and Osteoarthritis. Cells 2018, 7, 92. [CrossRef]","[67, 1068, 707, 1089]",reference_item,0.85,"[""reference content label: 208. Malemud, C.J. MicroRNAs and Osteoarthritis. Cells 2018,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,20,reference_content,"209. Al-Modawi, R.N.; Brinchmann, J.E.; Karlsen, T.A. Multi-pathway Protective Effects of MicroRNAs on Human Chondrocytes in an In Vitro Model of Osteoarthritis. Mol. Ther.—Nucleic Acids 2019, 17, 776","[67, 1091, 1123, 1135]",reference_item,0.85,"[""reference content label: 209. Al-Modawi, R.N.; Brinchmann, J.E.; Karlsen, T.A. Multi-""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,21,reference_content,"210. Wang, H.; Zhang, H.; Sun, Q.; Wang, Y.; Yang, J.; Yang, J.; Zhang, T.; Luo, S.; Wang, L.; Jiang, Y.; et al. Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Mat","[67, 1137, 1123, 1203]",reference_item,0.85,"[""reference content label: 210. Wang, H.; Zhang, H.; Sun, Q.; Wang, Y.; Yang, J.; Yang,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,22,reference_content,"211. Hu, G.; Zhao, X.; Wang, C.; Geng, Y.; Zhao, J.; Xu, J.; Zuo, B.; Zhao, C.; Wang, C.; Zhang, X. MicroRNA-145 attenuates TNF-alpha-driven cartilage matrix degradation in osteoarthritis via direct s","[67, 1206, 1123, 1272]",reference_item,0.85,"[""reference content label: 211. Hu, G.; Zhao, X.; Wang, C.; Geng, Y.; Zhao, J.; Xu, J.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,23,reference_content,"212. Li, L.; Jia, J.; Liu, X.; Yang, S.; Ye, S.; Yang, W.; Zhang, Y. MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes. Curr. Pharm. Des. 2015, 21, 5160–5167. [C","[67, 1275, 1122, 1319]",reference_item,0.85,"[""reference content label: 212. Li, L.; Jia, J.; Liu, X.; Yang, S.; Ye, S.; Yang, W.; Z""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,24,reference_content,"213. Zhang, Y.; Jia, J.; Yang, S.; Liu, X.; Ye, S.; Tian, H. MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes. Exp. Mol. Med. 2014, 46, e79. [CrossRef] [PubMed","[68, 1321, 1121, 1365]",reference_item,0.85,"[""reference content label: 213. Zhang, Y.; Jia, J.; Yang, S.; Liu, X.; Ye, S.; Tian, H.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,25,reference_content,"214. Li, J.; Huang, J.; Dai, L.; Yu, D.; Chen, Q.; Zhang, X.; Dai, K. miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4. Arth","[68, 1367, 1120, 1412]",reference_item,0.85,"[""reference content label: 214. Li, J.; Huang, J.; Dai, L.; Yu, D.; Chen, Q.; Zhang, X.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,26,reference_content,"215. Liu, X.; Liu, L.; Zhang, H.; Shao, Y.; Chen, Z.; Feng, X.; Fang, H.; Zhao, C.; Pan, J.; Zhang, H.; et al. MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin. Aging","[68, 1414, 1120, 1458]",reference_item,0.85,"[""reference content label: 215. Liu, X.; Liu, L.; Zhang, H.; Shao, Y.; Chen, Z.; Feng, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +24,27,reference_content,"216. Zhai, X.; Meng, R.; Li, H.; Li, J.; Jing, L.; Qin, L.; Gao, Y. miR-181a Modulates Chondrocyte Apoptosis by Targeting Glycerol-3-Phosphate Dehydrogenase 1-Like Protein (GPD1L) in Osteoarthritis. M","[67, 1460, 1123, 1526]",reference_item,0.85,"[""reference content label: 216. Zhai, X.; Meng, R.; Li, H.; Li, J.; Jing, L.; Qin, L.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +25,0,header,"Biomedicines 2022, 10, 1477","[68, 112, 258, 131]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +25,1,number,25 of 25,"[1061, 112, 1121, 130]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +25,2,reference_content,"217. Li, Z.; Meng, D.; Li, G.; Xu, J.; Tian, K.; Li, Y. Overexpression of microRNA-210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF-3α in osteoarthritis. Mol","[67, 194, 1120, 239]",reference_item,0.85,"[""reference content label: 217. Li, Z.; Meng, D.; Li, G.; Xu, J.; Tian, K.; Li, Y. Over""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +25,3,reference_content,"218. Jones, S.; Watkins, G.; Le Good, N.; Roberts, S.; Murphy, C.; Brockbank, S.; Needham, M.; Read, S.; Newham, P. The identification of differentially expressed microRNA in osteoarthritic tissue tha","[71, 241, 1122, 306]",reference_item,0.85,"[""reference content label: 218. Jones, S.; Watkins, G.; Le Good, N.; Roberts, S.; Murph""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +25,4,reference_content,"219. Bazzoni, F.; Rossato, M.; Fabbri, M.; Gaudiosi, D.; Mirolo, M.; Mori, L.; Tamassia, N.; Mantovani, A.; Cassatella, M.A.; Locati, M. Induction and regulatory function of miR-9 in human monocytes a","[67, 310, 1122, 375]",reference_item,0.85,"[""reference content label: 219. Bazzoni, F.; Rossato, M.; Fabbri, M.; Gaudiosi, D.; Mir""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +25,5,reference_content,"220. Park, S.J.; Cheon, E.J.; Kim, H.A. MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1beta-induced catabolic effects in human articular chondrocytes. Osteoarthr. Cartil. 2013, 21, ","[68, 378, 1120, 421]",reference_item,0.85,"[""reference content label: 220. Park, S.J.; Cheon, E.J.; Kim, H.A. MicroRNA-558 regulat""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/tests/fixtures/ocr_real_papers/3CEUN7T3/block_trace.csv b/tests/fixtures/ocr_real_papers/3CEUN7T3/block_trace.csv new file mode 100644 index 00000000..3b524304 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/3CEUN7T3/block_trace.csv @@ -0,0 +1,172 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593 https://doi.org/10.1007/s00167-023-07508-7","[98, 64, 560, 109]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +1,1,text,SHOULDER,"[110, 129, 218, 151]",authors,0.6,"[""page-1 initial-lastname author byline: SHOULDER""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,2,image,,"[1030, 132, 1089, 190]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,3,doc_title,Gender and degree of tendon healing are independent predictive factors for clinical outcome in successfully healed rotator cuff tears,"[97, 209, 956, 280]",paper_title,0.8,"[""page-1 zone title_zone: Gender and degree of tendon healing are independent predicti""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,Koray Şahin $ ^{1} $ ☑. Muhammed Oğuzhan Albayrak $ ^{2} $ ☑. Fatih Şentürk $ ^{3} $ ☑. Mehmet Ersin $ ^{4} $ ☑. Ali Erşen $ ^{2} $,"[96, 313, 895, 339]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,5,text,Received: 30 March 2023 / Accepted: 5 July 2023 / Published online: 15 July 2023,"[97, 373, 629, 394]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 30 March 2023 / Accepted: 5 July 2023 / Published ""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,6,text,"© The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2023","[96, 395, 918, 416]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 The Author(s) under exclusive licence to European Society ""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,7,paragraph_title,Abstract,"[97, 450, 183, 472]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,body_zone,heading_like,short_fragment,True,True +1,8,abstract,urpose Arthroscopic rotator cuff repair (aRCR) is a commonly performed procedure and has been reported to be a success l treatment. Successful healing has traditionally been considered to be associate,"[119, 475, 1081, 578]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,9,abstract,Methods This retrospective case–control study was conducted in a single center with 135 patients who had successfully healed tendons based on Sugaya classification (grades I–III) on postoperative magn,"[96, 576, 1094, 699]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,10,abstract,"Results Mean age of patients was $ 55.9 \pm 9.0 $ years and mean follow-up duration was $ 46.8 \pm 14.9 $ months. There were 50 (37%) male and 85 (63.0%) female patients. At final follow-up, mean CM","[96, 701, 1094, 925]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,11,abstract,"Conclusions This study showed that despite achieving a successful healing, considerable amount of patients (17.8%) have ended up with poor outcome. Female gender and degree of tendon healing were iden","[96, 926, 1094, 1024]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,12,text,Keywords Rotator cuff tear · Rotator cuff healing · Predictive factor · Outcome,"[96, 1051, 734, 1076]",structured_insert,0.7,"[""frontmatter noise text: Keywords Rotator cuff tear \u00b7 Rotator cuff healing \u00b7 Predicti""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,13,paragraph_title,Introduction,"[608, 1124, 750, 1149]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,14,footnote,"☒ Koray Şahin +drkoraysahin@gmail.com","[97, 1184, 311, 1228]",footnote,0.7,"[""footnote label: \u2612 Koray \u015eahin\ndrkoraysahin@gmail.com""]",footnote,0.7,body_zone,body_like,none,True,True +1,15,footnote," $ ^{1} $ Department of Orthopedics and Traumatology, Bezmialem Vakif University, Istanbul, Turkey","[97, 1244, 540, 1287]",footnote,0.7,"[""footnote label: $ ^{1} $ Department of Orthopedics and Traumatology, Bezmial""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,16,text,Rotator cuff disease is the main cause of admission to primary care due to shoulder pain and dysfunction [14]. Non-operative management is the first line of treatment recommended for majority of sympt,"[604, 1176, 1094, 1427]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,footnote," $ ^{2} $ Department of Orthopedics and Traumatology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey","[96, 1294, 527, 1338]",footnote,0.7,"[""footnote label: $ ^{2} $ Department of Orthopedics and Traumatology, Istanbu""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,18,footnote," $ ^{3} $ Department of Orthopedics and Traumatology, Hendek State Hospital, Sakarya, Turkey","[97, 1345, 548, 1387]",footnote,0.7,"[""footnote label: $ ^{3} $ Department of Orthopedics and Traumatology, Hendek ""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,19,footnote," $ ^{4} $ Department of Orthopedics and Traumatology, Istanbul Haseki Training and Research Hospital, Istanbul, Turkey","[96, 1394, 521, 1438]",footnote,0.7,"[""footnote label: $ ^{4} $ Department of Orthopedics and Traumatology, Istanbu""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,20,footer_image,,"[1002, 1470, 1091, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,0,number,4586,"[99, 63, 138, 82]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[627, 62, 1092, 84]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,2,text,"conservative management is associated with increase in tear size and inferior outcomes in long term [26]. Therefore, aRCR has been reported to be a successful treatment with significant pain relief an","[95, 113, 582, 238]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Previous outcome studies reported significant correlation between successful healing of the repaired cuff and good clinical outcomes [15, 16, 22, 28, 38]. Achieving complete structural integrity of th","[96, 239, 583, 713]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,The purpose of this study is to evaluate patients with successfully healed tendons following aRCR and to determine predictive factors causing poor final outcome in this specific patient group. It has ,"[95, 714, 582, 864]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,paragraph_title,Materials and methods,"[97, 911, 350, 937]",section_heading,0.9,"[""explicit scholarly heading: Materials and methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,6,text,"Institutional review board approval (E-67690154-050.03.04-1110453) was obtained from Istanbul University Istanbul Faculty of Medicine, and written inform consents were obtained from all included patie","[95, 962, 582, 1214]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,Patient selection,"[97, 1237, 259, 1261]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Patient selection""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,8,text,"Records of 454 patients who underwent aRCR procedure during study period by the senior author were reviewed. Surgery was indicated in case of persistent pain, discomfort or shoulder dysfunction despit","[95, 1288, 582, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"and rehabilitation. All decisions for surgery were given by +the senior author with preoperative clinical evaluation and +confirmation of presence of a full-thickness RCT using pre- +operative magnetic r","[604, 113, 1093, 213]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,"Inclusion criteria were (1) full-thickness RCT treated with transosseous equivalent (TOE) aRCR technique, (2) presence of a structural outcome data of the repair using postoperative MRI scans obtained","[604, 214, 1094, 587]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,text,"Records of 454 patients who underwent aRCR during study period were evaluated and 354 patients met the inclusion criteria. Among these 354 patients, 52 patients had subscapularis tears, 76 patients ha","[605, 588, 1093, 915]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,paragraph_title,Surgical procedure,"[607, 937, 789, 963]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Surgical procedure""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,13,text,"All surgeries were performed by the senior author with patients positioned in beach chair position under general anaesthesia. Following diagnostic arthroscopy through standard posterior portal, tenoto","[604, 988, 1093, 1263]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,text,A knotless TOE aRCR repair was then performed using a previously described technique [33]. Tear size was taken into consideration in order to determine number of medial row anchors. One anchor (Healic,"[604, 1264, 1095, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,footer_image,,"[99, 1470, 189, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[97, 62, 561, 84]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +3,1,number,4587,"[1053, 63, 1091, 82]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,figure_title,"Table 1 Preoperative demographic, clinical and intraoperative data of patients (data are reported as mean ± standard deviation or n (%))","[97, 112, 303, 235]",table_caption,0.9,"[""table prefix matched: Table 1 Preoperative demographic, clinical and intraoperativ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,3,table,"
Preoperative demographic, clinical and operative variable (n = 135)Data
GenderMale 50 (37.0), female 85 (63.0)
Age (years)55","[348, 114, 1090, 527]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,4,vision_footnote,"BMI body mass index, CMS Constant–Murley score, LHBT long head of biceps tendon","[352, 539, 953, 563]",footnote,0.7,"[""vision_footnote label: BMI body mass index, CMS Constant\u2013Murley score, LHBT long he""]",footnote,0.7,body_zone,body_like,none,True,True +3,5,text,small tears and two anchors for medium-sized tears. Repair was completed using one knotless lateral row anchor (Footprint PK; Smith&Nephew).,"[95, 610, 583, 688]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,Postoperative rehabilitation,"[97, 709, 363, 736]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Postoperative rehabilitation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,7,text,All patients underwent same standardized postoperative protocol and were followed up by the same physiotherapist starting from 1st postoperative day. All patients were immobilized for 4 weeks using an,"[95, 760, 583, 1088]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,paragraph_title,Clinical variables and patient assessment,"[97, 1109, 480, 1135]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical variables and patient assessment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,9,text,"All patients underwent preoperative clinical evaluation 1 day before the surgery by the first author. Postoperative clinical evaluations were also performed by the same author at 2 weeks, 6 weeks, 3 m","[95, 1160, 583, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"group (group II) consisted of patients with postoperative +CMS > 75. The cutoff score of 75 points was determined +according to the reported minimal clinical important dif- +ference (MCID) of CMS which i","[604, 611, 1093, 787]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,text,Other clinical outcome measures included pain score and ROM measurements. Pain score was assessed using a visual analogue scale (VAS) in a 10 points scale with 0 point indicating no pain and 10 points,"[604, 787, 1095, 1211]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,paragraph_title,Radiologic assessment,"[607, 1235, 823, 1260]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Radiologic assessment""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,13,text,All included patients underwent preoperative MRI to confirm full-thickness RCT diagnosis and to evaluate tear characteristics and also postoperative MRI at a mean of $ 13.0 \pm 2.1 $ months in order ,"[604, 1286, 1095, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,footer_image,,"[1002, 1471, 1091, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +4,0,number,4588,"[99, 63, 138, 81]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[627, 62, 1092, 84]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +4,2,text,classification described by DeOrio and Cofield [8]. Patte classification [30] was used on preoperative T2-weighted coronal oblique images in order to assess tear retraction. Degree of fatty infiltrati,"[96, 111, 582, 536]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"All MRI scans were obtained using a 1.5-Tesla magnetic resonance unit (Magnetom Aera, Siemens) equipped with a dedicated shoulder coil with upper extremity positioned in neutral position. Axial, sagit","[95, 536, 583, 788]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,Statistical analysis,"[97, 810, 274, 835]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,5,text,"Descriptive statistical methods used in order to analyze study data were mean, median, standard deviation, range, frequency and percentage. Normality distribution of continuous variables was performed","[95, 861, 582, 1161]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,A multivariate logistic regression analysis was conducted with statistically significant factors which were observed in the univariate analysis in order to determine independent predictive factors for,"[95, 1162, 583, 1361]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"Post hoc power analysis of the logistic regression model was performed using the rule of thumb of “events per variable” (EPV). Historically, ten events per variable were suggested to reach the necessa","[95, 1362, 583, 1436]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"suggested to reach the necessary power in logistic regression +models [32]. However, recent statistical knowledge suggests +that rule of ten EPV can be relaxed in case of results from +any logistic model","[605, 112, 1093, 261]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,Number of independent variables was kept minimum in the logistic regression model by performing a univariate analysis and by eliminating irrelevant covariates which gave the statistical advantage to t,"[605, 263, 1095, 563]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,paragraph_title,Results,"[607, 633, 694, 660]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,11,text,"Comparisons of preoperative clinical outcome measures including ROM, functional score and pain score between two study groups showed that two study groups were comparable preoperatively (n.s.). Group ","[604, 687, 1094, 1036]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,"Possible predictive factors affecting final clinical outcome were evaluated in a univariate analysis (Table 3). It was observed that gender, body mass index (BMI) and postoperative structural outcome ","[605, 1037, 1093, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,footer_image,,"[99, 1470, 189, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[98, 62, 561, 84]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +5,1,number,4589,"[1053, 63, 1091, 81]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,figure_title,Table 2 Preoperative and postoperative clinical outcome data of study groups,"[97, 111, 314, 175]",table_caption,0.9,"[""table prefix matched: Table 2 Preoperative and postoperative clinical outcome data""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,3,table,"
Group I (poor outcome, n=24)Group II (good outcome, n=111)p valueMean or median difference (95% CI)
Abduction, degrees
Group I (poor outcome, n=24)Group II (good outcome, n=111)p valueMean or median difference (95% CI)Odds ratio (95% CI)
Gend","[96, 118, 1088, 804]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,vision_footnote,Data reported as mean ± standard deviation or n (%). Bolded p values indicate statistical significance,"[97, 815, 790, 838]",footnote,0.7,"[""vision_footnote label: Data reported as mean \u00b1 standard deviation or n (%). Bolded ""]",footnote,0.7,body_zone,body_like,none,True,True +6,5,vision_footnote,"BMI body mass index, CMS Constant–Murley score, VAS visual analogue scale, LHBT long head of biceps tendon, CI confidence interval, n.s. non-significant. $ {}^{a} $Chi-square test, $ {}^{b} $Mann–Wh","[96, 842, 1091, 885]",footnote,0.7,"[""vision_footnote label: BMI body mass index, CMS Constant\u2013Murley score, VAS visual a""]",footnote,0.7,body_zone,body_like,none,True,True +6,6,figure_title,Table 4 Multivariate logistic regression analysis of predictive factors associated with poor clinical outcome (bolded p values indicate statistical significance),"[97, 938, 582, 1001]",table_caption,0.9,"[""table prefix matched: Table 4 Multivariate logistic regression analysis of predict""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,7,table,
VariableOdds ratio95% CIp value
Gender (female)3.651.13-14.70.04
BMI1.070.96-1.,"[98, 1008, 578, 1175]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,8,vision_footnote,"BMI body mass index, CI confidence interval, n.s. non-significant","[97, 1188, 552, 1211]",footnote,0.7,"[""vision_footnote label: BMI body mass index, CI confidence interval, n.s. non-signif""]",footnote,0.7,body_zone,body_like,none,True,True +6,9,text,"Consistent to these data, it was showed by the findings of the present study that female gender was an independent predictive factor for poor clinical outcome in patients with healed RCTs. Some possib","[95, 1261, 583, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"dressing, and that women might have different subjective +symptom perception compared to men.","[606, 936, 1092, 986]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,text,Findings of the present study showed that second independent predictive factor affecting final outcome was the degree of tendon healing. Even though grade I and II healing according to Sugaya classifi,"[604, 987, 1094, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,12,footer_image,,"[99, 1470, 189, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +7,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[97, 62, 561, 84]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,1,number,4591,"[1053, 64, 1090, 82]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,showed that higher signal intensity of the repaired tendon on postoperative MRI scans was significantly higher in patients with residual pain and that there was a significant association between pain ,"[96, 112, 583, 386]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,Obesity has been recently reported as a risk factor for poor healing of RCTs $ [10] $ and as negative contributor to recovery following aRCR $ [37] $ considering higher risk of anesthesia-related co,"[96, 387, 583, 636]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"Determination of all contributors to clinical outcome is difficult since it is affected by numerous factors. The present study mainly focused on several physical factors; however, it is obvious that p","[96, 637, 582, 961]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,This study has several limitations that need to be noted. Retrospective nature of the study is the first limitation that should be mentioned which may have cause selection bias and other unanticipated,"[96, 963, 583, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,6,text,"Another limitation is that type of diabetes and level of gly- +cemic control data which are potentially important for our +results were not available for analysis. This variable was +evaluated only relyi","[605, 111, 1093, 210]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"This study also has some strength that needs to be mentioned. Compared to similar studies on this topic [27], the study was conducted in a single center and all patients were operated by a single surg","[605, 213, 1094, 563]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,Conclusion,"[608, 634, 734, 660]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +7,9,text,"This study showed that despite successful healing of repaired tendon confirmed on postoperative MRI scans, 17.8% of the patients experienced poor clinical outcomes. Female gender and the degree of ten","[605, 686, 1093, 889]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,Funding No funding was received for this study.,"[606, 928, 948, 951]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,paragraph_title,Declarations,"[608, 970, 732, 994]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Declarations""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +7,12,text,Conflict of interest None.,"[607, 1013, 790, 1035]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +7,13,text,Ethical approval IRB approval was obtained from institutional review board of Istanbul University Istanbul Faculty of Medicine with IRB ID number: E-67690154-050.03.04-1110453.,"[606, 1053, 1092, 1116]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,14,paragraph_title,References,"[609, 1198, 734, 1224]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +7,15,reference_content,"1. 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Longo UG, Risi Ambrogioni L, Candela V, Berton A, Carnevale A, Schena E et al (2021) Conservative versus surgical management for patients with rotator cuff tears: a systematic review and META-anal","[609, 272, 1091, 369]",reference_item,0.85,"[""reference content label: 23. Longo UG, Risi Ambrogioni L, Candela V, Berton A, Carnev""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,23,reference_content,"24. Maher A, Leigh W, Young S, Caughey W, Hoffman T, Brick M et al (2022) Do age, demographics, and tear characteristics affect outcomes after rotator cuff repair? Results of over 2000 rotator cuff re","[610, 372, 1091, 488]",reference_item,0.85,"[""reference content label: 24. Maher A, Leigh W, Young S, Caughey W, Hoffman T, Brick M""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True +8,24,reference_content,"25. Mall NA, Tanaka MJ, Choi LS, Paletta GA (2014) Factors affecting rotator cuff healing. 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Orthop Traumatol Surg Res 107(8S):103100. https://doi.org/10","[610, 632, 1091, 710]",reference_item,0.85,"[""reference content label: 27. Nabergoj M, Bagheri N, Bonnevialle N, Gallinet D, Barth ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,27,reference_content,"28. Noyes MP, Ladermann A, Denard PJ (2019) Functional outcome and healing with a load-sharing rip-stop repair compared with a single-row repair for large and massive rotator cuff tears. Arthroscopy 3","[611, 712, 1090, 790]",reference_item,0.85,"[""reference content label: 28. Noyes MP, Ladermann A, Denard PJ (2019) Functional outco""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,28,reference_content,"29. Paloneva J, Lepola V, Aärimaa V, Joukainen A, Ylinen J, Mattila VM (2015) Increasing incidence of rotator cuff repairs—a nationwide registry study in Finland. BMC Musculoskelet Disord 16:189. http","[610, 793, 1091, 869]",reference_item,0.85,"[""reference content label: 29. Paloneva J, Lepola V, A\u00e4rimaa V, Joukainen A, Ylinen J, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,29,reference_content,30. Patte D (1990) Classification of rotator cuff lesions. Clin Orthop Relat Res 254:81–86,"[610, 872, 1090, 910]",reference_item,0.85,"[""reference content label: 30. Patte D (1990) Classification of rotator cuff lesions. C""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,30,reference_content,"31. Paul S, Goyal T, Yadav AK (2022) Association between functional outcome scores and MRI-based structural integrity after rotator cuff repair: a prospective cohort study. Arch Orthop Trauma Surg 142","[611, 912, 1091, 990]",reference_item,0.85,"[""reference content label: 31. Paul S, Goyal T, Yadav AK (2022) Association between fun""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,31,reference_content,"32. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49(12):1373–1379","[610, 992, 1091, 1069]",reference_item,0.85,"[""reference content label: 32. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,32,reference_content,"33. Şahin K, Şentürk F, Ersin M, Arzu U, Chodza M, Erşen A (2021) Repair integrity and functional outcomes between knot-tying and knotless suture-bridge arthroscopic rotator cuff repair: a prospective","[611, 1072, 1091, 1188]",reference_item,0.85,"[""reference content label: 33. \u015eahin K, \u015eent\u00fcrk F, Ersin M, Arzu U, Chodza M, Er\u015fen A (""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,33,reference_content,"34. Sugaya H, Maeda K, Matsuki K, Moriishi J (2007) Repair integrity and functional outcome after arthroscopic double-row rotator cuff repair. A prospective outcome study. J Bone Jt Surg Am. 89(5):953","[609, 1192, 1090, 1269]",reference_item,0.85,"[""reference content label: 34. Sugaya H, Maeda K, Matsuki K, Moriishi J (2007) Repair i""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,34,reference_content,"35. Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165(6):710–718","[611, 1272, 1090, 1330]",reference_item,0.85,"[""reference content label: 35. Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,35,reference_content,"36. Voigt C, Bosse C, Vosshenrich R, Schulz AP, Lill H (2010) Arthroscopic supraspinatus tendon repair with suture-bridging technique: functional outcome and magnetic resonance imaging. Am J Sports Me","[610, 1333, 1091, 1410]",reference_item,0.85,"[""reference content label: 36. Voigt C, Bosse C, Vosshenrich R, Schulz AP, Lill H (2010""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,36,footer_image,,"[99, 1471, 188, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +9,0,header,"Knee Surgery, Sports Traumatology, Arthroscopy (2023) 31:4585–4593","[98, 63, 560, 83]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +9,1,number,4593,"[1054, 64, 1091, 81]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +9,2,reference_content,"37. Warrender WJ, Brown OL, Abboud JA (2011) Outcomes of arthroscopic rotator cuff repairs in obese patients. J Shoulder Elbow Surg 20(6):961–967","[100, 113, 582, 171]",reference_item,0.85,"[""reference content label: 37. Warrender WJ, Brown OL, Abboud JA (2011) Outcomes of art""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,3,reference_content,"38. Wylie JD, Baran S, Granger EK, Tashjian RZ (2018) A comprehensive evaluation of factors affecting healing, range of motion, strength, and patient-reported outcomes after arthroscopic rotator cuff ","[101, 174, 580, 270]",reference_item,0.85,"[""reference content label: 38. Wylie JD, Baran S, Granger EK, Tashjian RZ (2018) A comp""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,4,reference_content,"39. Wylie JD, Suter T, Potter MQ, Granger EK, Tashjian RZ (2016) Mental health has a stronger association with patient-reported shoulder pain and function than tear size in patients with full-thicknes","[101, 273, 580, 351]",reference_item,0.85,"[""reference content label: 39. Wylie JD, Suter T, Potter MQ, Granger EK, Tashjian RZ (2""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,5,reference_content,"40. Yoo JC, Ahn JH, Koh KH, Lim KS (2009) Rotator cuff integrity after arthroscopic repair for large tears with less-than-optimal footprint coverage. Arthroscopy 25(10):1093–1100","[99, 353, 581, 412]",reference_item,0.85,"[""reference content label: 40. Yoo JC, Ahn JH, Koh KH, Lim KS (2009) Rotator cuff integ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,6,text,Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[607, 112, 1092, 154]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True +9,7,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[607, 173, 1093, 274]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,8,footer_image,,"[1003, 1471, 1090, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True diff --git a/tests/fixtures/ocr_real_papers/3CIQWBGA/block_trace.csv b/tests/fixtures/ocr_real_papers/3CIQWBGA/block_trace.csv new file mode 100644 index 00000000..90625db0 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/3CIQWBGA/block_trace.csv @@ -0,0 +1,295 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,"Biomaterials Research +A SCIENCE PARTNER JOURNAL","[96, 60, 411, 121]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,text,RESEARCH ARTICLE,"[95, 173, 307, 203]",authors,0.6,"[""page-1 initial-lastname author byline: RESEARCH ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,2,doc_title,Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects,"[95, 219, 742, 391]",paper_title,0.8,"[""page-1 zone title_zone: Enhanced Chondrogenic Differentiation of Electrically Primed""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,"Jongdarm Yi $ ^{1} $, Yujin Byun $ ^{2,3} $, Seong Soo Kang $ ^{2,3} $, Kyung Mi Shim $ ^{2,3} $, Kwangsik Jang $ ^{2,3*} $, and Jae Young Lee $ ^{1*} $","[94, 397, 769, 462]",authors,0.8,"[""page-1 zone author_zone: Jongdarm Yi $ ^{1} $, Yujin Byun $ ^{2,3} $, Seong Soo Kang ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text," $ ^{1} $School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. $ ^{2} $Department of Veterinary Surgery, College of Veterinary Me","[94, 475, 838, 584]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $School of Materials Science and Engineering, Gwangju""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,5,text,*Address correspondence to: jaeyounglee@gist.ac.kr (J.Y.L.); rhkdtlr0327@nate.com (K.J.),"[95, 603, 743, 629]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: *Address correspondence to: jaeyounglee@gist.ac.kr (J.Y.L.);""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,6,abstract,"Background: Mesenchymal stem cells (MSCs) offer a promising avenue for cartilage regeneration; however, their therapeutic efficacy requires substantial improvement. Cell priming using electrical stimu","[93, 650, 839, 1030]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,7,paragraph_title,Introduction,"[96, 1100, 230, 1126]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,8,text,"The articular cartilage is a specialized connective tissue covering the bone ends in synovial joints; it provides a smooth, lubricated surface for low-friction articulation and serves as a shock absor","[94, 1141, 593, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,vision_footnote,"Citation: Yi J, Byun Y, Kang SS, Shim KM, Jang K, Lee JY. Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects. Bioma","[869, 295, 1098, 470]",footnote,0.7,"[""vision_footnote label: Citation: Yi J, Byun Y, Kang SS, Shim KM, Jang K, Lee JY. En""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,10,text,"Submitted 4 June 2024 +Revised 12 October 2024 +Accepted 26 October 2024 +Published 18 December 2024","[869, 487, 1063, 568]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Submitted 4 June 2024\nRevised 12 October 2024\nAccepted 26 Oc""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,vision_footnote,"Copyright © 2024 Jongdarm Yi et al. +Exclusive licensee Korean Society for Biomaterials, Republic of Korea. +No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution ","[869, 583, 1111, 721]",frontmatter_noise,0.75,"[""page-1 DOI/date footnote: Copyright \u00a9 2024 Jongdarm Yi et al.\nExclusive licensee Korea""]",frontmatter_noise,0.75,frontmatter_main_zone,support_like,none,False,False +1,12,text,"(MSCs) have garnered substantial attention in cell therapy as an alternative because of their ease of isolation from diverse sources (e.g., adipose tissue, umbilical cord blood, bone marrow, and Whart","[618, 1096, 1119, 1275]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,13,text,"Many studies have used MSCs to treat articular cartilage defects. For instance, Park et al. [7] injected umbilical cord blood-derived MSCs with hyaluronic acid (HA)-based hydrogels into a knee full-th","[618, 1273, 1119, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95, 1531, 464, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,15,number,1,"[1103, 1532, 1116, 1552]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,0,header,Biomaterials Research,"[833, 62, 1102, 96]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,text,"diseases, including articular cartilage defects. For example, human synovium-derived MSCs cultured under hypoxic conditions showed enhanced colony-forming characteristics, up-regulated messenger RNA (","[79, 126, 579, 391]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,2,text,"Inherent bioelectrical signals are involved in various physiological functions, including intercellular transmission and reception of electrical signals [11]. Hence, ES has been increasingly explored ","[79, 390, 579, 875]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"In this study, we aimed to enhance the chondrogenic differentiation of human MSCs by employing appropriate ES and facilitate the restoration of articular cartilage in vivo (Fig. 1). Specifically, we i","[80, 874, 579, 1076]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,image,,"[84, 1110, 574, 1400]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,5,figure_title,"Fig.1. Schematic illustration of electrically primed mesenchymal stem cells (epMSCs) and their chondrogenic potential and regeneration ability in articular cartilage. MSCs, mesenchymal stem cells; ES,","[81, 1412, 579, 1494]",figure_caption_candidate,0.85,"[""figure_title label: Fig.1. Schematic illustration of electrically primed mesench""]",figure_caption,0.85,body_zone,legend_like,none,False,False +2,6,text,and epMSCs to validate the ES-induced alterations in gene expression.,"[604, 126, 1103, 173]",unknown_structural,0.8,"[""page-1 zone title_zone: and epMSCs to validate the ES-induced alterations in gene ex""]",paper_title,0.8,body_zone,body_like,none,False,True +2,7,paragraph_title,Materials and Methods Materials,"[606, 201, 846, 267]",unknown_structural,0.8,"[""page-1 zone author_zone: Materials and Methods Materials""]",authors,0.8,frontmatter_side_zone,heading_like,none,False,True +2,8,footer,,"[606, 243, 703, 267]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,9,text,"Human adipose-derived MSCs (hAD-MSCs) were purchased from PromoCell (Heidelberg, Germany). For ES, 316-L stainless-steel plates (3.8 cm × 2.8 cm × 0.7 cm) were obtained from BKSTEEL (Siheung, Republic","[602, 269, 1104, 933]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,Cell culture and investigation of ES on MSCs,"[605, 962, 1025, 986]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell culture and investigation of ES on MSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,11,text,"hAD-MSCs at passage 5 were used in all experiments. For maintenance, MSCs (1.0 × 10⁴ cells/cm²) were seeded on tissue culture plates and cultured in the growth medium (minimum essential medium-alpha s","[602, 987, 1104, 1229]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,text,"ES of the MSCs was performed using a 2-electrode system consisting of a platinum mesh (5 mm × 10 mm) and a cell-seeded stainless-steel plate as the counter and working electrodes, respectively. A copp","[604, 1230, 1104, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82, 1531, 450, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,14,number,2,"[1086, 1532, 1103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,Biomaterials Research,"[847, 62, 1116, 96]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +3,1,text,"were refreshed before the initial ES on day 1, and no further media were exchanged throughout the 3-d ES.","[94, 126, 592, 171]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,2,text,The cytocompatibility of MSCs subjected to different ES conditions was assessed using the LIVE/DEAD assay kit and metabolic activity measurements. Cell viability and metabolic activity were measured t,"[93, 171, 593, 657]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,Fluorescence-activated cell sorting analysis,"[94, 679, 511, 704]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Fluorescence-activated cell sorting analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,4,text,"One day after ES (on day 4 of the entire experimental period), MSCs were stained for stemness markers and analyzed by flow cytometry. Briefly, the cells were detached using 0.05% trypsin–EDTA, washed ","[93, 704, 593, 994]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Chondrogenic differentiation of MSCs,"[95, 1017, 455, 1042]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Chondrogenic differentiation of MSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,6,text,"The chondrogenic medium was prepared by adding 0.3 mM ascorbic acid, 0.35 mM L-proline, 0.1 μM dexamethasone, 1× ITS+3, and 10 ng/ml TGF-β3 in a high-glucose Dulbecco's modified Eagle's medium. One da","[92, 1042, 594, 1309]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,paragraph_title,Quantitative real-time polymerase chain reaction analysis,"[94, 1332, 477, 1383]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Quantitative real-time polymerase chain reaction analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,8,text,Quantitative real-time polymerase chain reaction (PCR) was performed after 14 d of culture in the chondrogenic medium. Total RNA was extracted from each group using the TRIzol reagent according to the,"[93, 1383, 593, 1498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"ultraviolet–visible spectrophotometer (BioDrop Duo, BioDrop, +United Kingdom). Complementary DNA (cDNA) was synthe- +sized from the isolated mRNA using the High-Capacity cDNA +Reverse Transcription Kit (","[617, 126, 1118, 571]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,paragraph_title,Quantification of the sGAG content,"[619, 598, 956, 622]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Quantification of the sGAG content""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,11,text,"The sGAG content in the cells was quantified using the DMMB assay. After 2-week incubation in the chondrogenic differentiation medium, the cell pellets were collected and washed twice with DPBS. There","[618, 624, 1119, 998]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,text,"The DNA content of the cells was quantified using the Quant-iT PicoGreen double-stranded DNA assay kit according to the manufacturer's protocol. Briefly, a DNA standard solution (100 µg/ml) was dilute","[617, 998, 1119, 1263]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,paragraph_title,Pellet histology analysis,"[619, 1292, 854, 1316]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Pellet histology analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,14,text,"The cell pellets were fixed with 3.7% formaldehyde for 30 min and washed twice with DPBS. Then, the samples were incubated in sucrose solution (30% [w/v] in DPBS) for 24 h and embedded in the optimal ","[617, 1316, 1119, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95, 1531, 464, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,16,number,3,"[1101, 1532, 1117, 1552]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Biomaterials Research,"[833, 61, 1102, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +4,1,text,"incubated in 3% acetic acid for 3 min, and incubated in the Alcian blue solution (pH 2.5) at 25 °C for 30 min. The tissue sections were gently washed under running tap water for 10 min, followed by 3 ","[79, 126, 579, 590]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,2,text,"For immunocytochemistry, the sections were first washed in DDIW for 1 min and incubated in methanol for 20 min. The slides were then washed twice with DPBS for 5 min each. Following this, the slides w","[79, 587, 580, 990]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,Establishment of the OCD model and surgical procedures,"[80, 1023, 430, 1074]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Establishment of the OCD model and surgical procedures""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,4,text,"All animal experiments were approved by the Institutional Animal Care and Use Committee of Chonnam National University (CNU, Gwangju, Republic of Korea) (approval number: CNU IACUC-YB-2023-113), and t","[79, 1075, 579, 1252]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"One day after the final ES, cells were detached using 0.05% trypsin–EDTA and centrifuged at 300×g for 5 min. Cells (1 × 10⁷ cells/ml) were then resuspended in 2% HA solution (w/v in DPBS).","[80, 1250, 578, 1338]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"The rat OCD model was established as previously described with slight modifications [7]. Animals were pre-anesthetized using 5 mg per kilogram of animal weight each of ketoprofen (EAGLE VET, Seoul, Re","[80, 1338, 579, 1497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,figure_title,Table. Detailed experimental groups for animal studies using an osteochondral defect model,"[625, 157, 1081, 205]",figure_caption_candidate,0.85,"[""figure_title label: Table. Detailed experimental groups for animal studies using""]",figure_caption,0.85,body_zone,legend_like,none,False,False +4,8,table,<,"[625, 215, 1080, 380]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,9,vision_footnote,"HA, hyaluronic acid; MSC, mesenchymal stem cells; epMSCs, electrically primed mesenchymal stem cells","[625, 394, 1082, 441]",footnote,0.7,"[""vision_footnote label: HA, hyaluronic acid; MSC, mesenchymal stem cells; epMSCs, el""]",footnote,0.7,body_zone,body_like,none,True,True +4,10,text,"injection for preventing infection and 1 mg of atropine (JEIL PHARM., Republic of Korea) per kg animal weight via subcutaneous injection for bradycardia prevention. Anesthesia was induced via intraper","[605, 525, 1104, 682]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,"The animal skin was disinfected with 10% povidone and alcohol, and a lateral parapatellar incision was made to expose the distal femoral trochlear groove surface. A full-thickness defect with a diamet","[604, 681, 1104, 1124]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,paragraph_title,Macroscopic evaluation of cartilage repair,"[605, 1160, 1005, 1185]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Macroscopic evaluation of cartilage repair""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,13,text,"Distal femurs, including the defect, were harvested after euthanasia at 4 and 8 weeks after surgery and transplantation for macroscopic evaluation and imaging. Cartilage regeneration was assessed macr","[602, 1185, 1104, 1497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[83, 1531, 450, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,15,number,4,"[1087, 1532, 1103, 1552]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,Biomaterials Research,"[848, 62, 1116, 96]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +5,1,paragraph_title,Micro-computed tomography analysis of subchondral bone repair,"[95, 125, 480, 176]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Micro-computed tomography analysis of subchondral bone repai""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,2,text,The harvested distal femurs were fixed in neutral-buffered 10% formalin. Micro-computed tomography (micro-CT) analysis was performed to verify the extent of new subchondral bone formation in vivo. The,"[92, 176, 594, 1060]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,paragraph_title,Histological analysis,"[95, 1093, 295, 1118]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histological analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,4,text,"Histological analysis of cartilage regeneration at the defect sites was performed using H&E, Masson's trichrome, Alcian blue, and Safranin-O staining. Additionally, immunohistochemical (IHC) staining ","[93, 1118, 593, 1497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,"contents in the cartilage, respectively. Additionally, 0.05% fast +green (Sigma-Aldrich) and Weigert hematoxylin solutions +(BioGnost, Zagreb, Croatia) were used to distinguish the sur- +rounding tissues","[618, 126, 1118, 568]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,"To quantitatively evaluate the degree of histological cartilage repair, the sections were analyzed using the O'Driscoll histological cartilage repair scale (Table S2) based on Safranin-O-stained image","[618, 568, 1119, 944]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,paragraph_title,Total RNA sequencing and data analysis,"[619, 960, 998, 984]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Total RNA sequencing and data analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,8,text,"From each sample, $ 1 \times 10^6 $ MSCs and epMSCs were collected for total RNA sequencing. Quantitative RNA sequencing (Quant-Seq) was performed in duplicate (Ebiogen, Seoul, Republic of Korea). Th","[617, 984, 1119, 1296]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,9,paragraph_title,Statistical analyses,"[619, 1314, 812, 1339]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical analyses""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,10,text,All tests were performed in quadruplicate $ (n = 4) $ unless otherwise noted. Results are reported as mean ± standard deviation unless otherwise noted. Differences between groups were analyzed using ,"[617, 1338, 1118, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95, 1531, 464, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,12,number,5,"[1101, 1531, 1117, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Biomaterials Research,"[833, 62, 1103, 96]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +6,1,paragraph_title,Results Cytocompatibility of ES conditions,"[80, 125, 413, 194]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Results Cytocompatibility of ES conditions""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +6,2,footer,,"[80, 169, 413, 194]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +6,3,text,"Appropriate ES is crucial for effective modulation of MSCs' characteristics without damaging their viability [20]. To this end, we examined the ES parameters of various previously reported ES systems ","[79, 193, 580, 594]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,text,"metabolic activity compared with that of both the unstimu- +lated (3.27 ± 0.04) and 0.3 V and 1 Hz (3.26 ± 0.08) groups +(Fig. 2 D). No significant differences in cell viability or meta- +bolic activity ","[604, 126, 1104, 259]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,text,"Moreover, ES-induced possible changes in stemness were investigated by analyzing the expression of stemness-related surface markers (Fig. 2E and Fig. S2). The stemness of MSCs is generally characteriz","[603, 259, 1105, 592]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,figure_title,A,"[89, 637, 111, 660]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,7,figure_title,B,"[474, 637, 492, 658]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,8,chart,,"[81, 746, 483, 876]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,image,,"[506, 655, 1098, 1004]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,10,figure_title,C,"[101, 1031, 122, 1053]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,11,figure_title,D,"[420, 1031, 441, 1054]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,12,chart,,"[112, 1075, 365, 1420]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,13,figure_title,E,"[736, 1031, 755, 1053]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,14,chart,,"[430, 1074, 676, 1418]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,15,chart,,"[745, 1075, 1010, 1364]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,16,figure_title,Fig. 2. Viability and stemness maintenance of human adipose-derived MSCs electrically stimulated under diverse parameters. (A) Schematic experimental timeline. (B) Representative fluorescent images of,"[80, 1433, 1103, 1496]",figure_caption,0.92,"[""figure_title label: Fig. 2. Viability and stemness maintenance of human adipose-""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,17,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82, 1531, 451, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,18,number,6,"[1087, 1531, 1103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Biomaterials Research,"[847, 61, 1117, 96]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +7,1,text,"MSCs, such as their immunomodulatory capacity and differentiation potential [24].","[94, 125, 591, 174]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,2,paragraph_title,In vitro chondrogenic differentiation of epMSCs,"[94, 190, 545, 215]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: In vitro chondrogenic differentiation of epMSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,3,text,The chondrogenic differentiation capability of epMSCs was assessed by analyzing the mRNA expression and extracellular matrix (ECM) production after 2 weeks of culture in chondrogenic media (Fig. 3A). ,"[93, 216, 593, 396]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"cartilage and involved in the early stages of chondrogenesis; it +serves as one of the earliest markers indicating the commitment +of cells to a chondrocyte lineage and the production of ECM +necessary f","[617, 126, 1120, 394]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,figure_title,A,"[142, 420, 164, 442]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,6,image,,"[152, 440, 783, 573]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,7,figure_title,B,"[143, 608, 163, 630]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,8,chart,,"[177, 623, 612, 940]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,9,figure_title,C,"[699, 609, 718, 630]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,10,chart,,"[701, 619, 992, 1005]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,11,figure_title,D,"[143, 1020, 162, 1040]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,12,image,,"[143, 1024, 609, 1384]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,F,"[855, 1019, 873, 1042]",figure_inner_text,0.9,"[""panel label / figure inner text: F""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,14,chart,,"[620, 1047, 845, 1393]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,15,chart,,"[856, 1057, 1072, 1393]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,16,figure_title,"Fig. 3. In vitro chondrogenic differentiation of epMSCs. (A) Schematic experimental timeline. (B) Relative expression of chondrogenic genes (COL2A1, SOX9, and ACAN) (n = 5). (C) Amount of sulfated gly","[95, 1411, 1120, 1496]",figure_caption,0.92,"[""figure_title label: Fig. 3. In vitro chondrogenic differentiation of epMSCs. (A)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,17,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95, 1531, 464, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,18,number,7,"[1101, 1531, 1117, 1552]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Biomaterials Research,"[833, 61, 1103, 96]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +8,1,text,"stages of chondrogenesis, plays a critical role in mediating chondrocyte–ECM interactions [27]. ACAN expression in the epMSC (0.3 V and 1 Hz) group was 8.5- and 3.9-fold higher than those in the unsti","[79, 126, 579, 281]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,2,text,"The sGAG content, a major component of the cartilage ECM, was significantly increased by ES at 0.3 V and 1 Hz from 7.1 ± 0.3 to 8.8 ± 0.9, whereas the production of sGAG in epMSCs (0.3 V and 100 Hz; 7","[79, 281, 580, 768]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,"Immunofluorescence staining for COL1 and COL2 further +verified the superior chondrogenic differentiation of the epMSCs +compared to that of MSCs (Fig. S3). epMSCs exhibited higher +expression of COL2 (a","[603, 125, 1104, 394]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,Macroscopic evaluations of cartilage regeneration,"[605, 410, 1080, 435]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Macroscopic evaluations of cartilage regeneration""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +8,5,text,"The in vivo therapeutic efficacy of epMSCs for cartilage regeneration was investigated in a rodent OCD model (Fig. S4). The experimental groups included untreated controls, HA-only, HA + MSCs, and HA ","[602, 435, 1104, 769]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,figure_title,A,"[83, 796, 105, 819]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,7,image,,"[85, 811, 1099, 1407]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,8,chart,,"[740, 1071, 1100, 1402]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,"Fig. 4. Macroscopic evaluation of cartilage repair in the rat model at 4 and 8 weeks after the surgery and treatments (nontreated control [Control], hyaluronic acid (HA)-only, HA + MSCs, and HA + epMS","[78, 1412, 1104, 1495]",figure_caption,0.92,"[""figure_title label: Fig. 4. Macroscopic evaluation of cartilage repair in the ra""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,10,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82, 1531, 451, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,11,number,8,"[1087, 1531, 1103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,Biomaterials Research,"[847, 61, 1117, 96]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +9,1,text,"of the control, HA-only, HA + MSCs, and HA + epMSCs groups at week 4 were $ 4.6 \pm 2.2 $, $ 5.7 \pm 1.7 $, $ 6.9 \pm 2.0 $, and $ 8.7 \pm 1.6 $, respectively. Notably, the HA + epMSCs group exhib","[93, 126, 593, 350]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,2,paragraph_title,Micro-CT evaluation of the newly formed subchondral bone,"[94, 363, 479, 414]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Micro-CT evaluation of the newly formed subchondral bone""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,3,text,"Because the articular cartilage of a rat is typically thin and micro-CT imaging has limited resolution, it was challenging to accurately compare the degrees of cartilage regeneration among all groups ","[93, 415, 594, 772]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,paragraph_title,Histological evaluations in the rat OCD model,"[94, 805, 525, 831]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histological evaluations in the rat OCD model""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,5,text,"H&E staining (Fig. 6A) showed that the articular cartilage of the HA + epMSCs group presented a smooth and regular surface morphology compared with those of the other groups. Similarly, Masson's trich","[94, 830, 594, 945]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,text,"distribution of collagen fibers in the regenerated cartilage (Fig. +6 B). Although the control group displayed faint Alcian blue +and Safranin-O staining, the HA + epMSCs group showed +distinct blue and ","[618, 125, 1119, 589]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,text,Quantitative analysis using the modified O'Driscoll histological cartilage repair scale further indicated that the HA + epMSCs group exhibited a higher proportion of hyaline cartilage and a higher sta,"[617, 590, 1119, 943]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,figure_title,A,"[96, 972, 119, 994]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,figure_title,B,"[676, 971, 695, 993]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,10,image,,"[98, 982, 1115, 1413]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,11,figure_title,Fig. 5. Micro-computed tomography (micro-CT) of the subchondral bone formation in the defect area (n = 5 for each group). (A) Three-dimensional (3D) reconstruction (yellow color indicates newly formed,"[95, 1432, 1117, 1495]",figure_caption,0.92,"[""figure_title label: Fig. 5. Micro-computed tomography (micro-CT) of the subchond""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,12,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[95, 1531, 465, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,13,number,9,"[1100, 1531, 1117, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,Biomaterials Research,"[833, 62, 1102, 96]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +10,1,paragraph_title,A H&E,"[82, 129, 186, 154]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: A H&E""]",subsection_heading,0.6,body_zone,unknown_like,short_fragment,True,True +10,2,image,,"[88, 189, 578, 390]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,3,figure_title,B Masson's trichrome,"[600, 127, 840, 154]",figure_caption_candidate,0.85,"[""figure_title label: B Masson's trichrome""]",figure_caption,0.85,body_zone,unknown_like,none,False,False +10,4,image,,"[609, 190, 1098, 392]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,5,figure_title,C Alcian blue,"[82, 416, 245, 441]",figure_caption_candidate,0.85,"[""figure_title label: C Alcian blue""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +10,6,image,,"[83, 471, 573, 671]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,7,figure_title,D Safranin-O,"[601, 416, 762, 441]",figure_caption_candidate,0.85,"[""figure_title label: D Safranin-O""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +10,8,image,,"[608, 465, 1099, 670]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,9,figure_title,E Type-II collagen (COL2),"[81, 704, 364, 733]",figure_caption,0.85,"[""figure_title label: E Type-II collagen (COL2)""]",figure_caption,0.85,body_zone,unknown_like,none,True,True +10,10,image,,"[84, 711, 574, 994]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,11,figure_title,F,"[602, 704, 620, 724]",figure_inner_text,0.9,"[""panel label / figure inner text: F""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,12,chart,,"[675, 704, 1017, 1008]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,13,figure_title,"Fig. 6. Histological and immunohistochemical (IHC) analyses of cartilage repair in the rat model at weeks 4 and 8 after transplantation. (A) Hematoxylin and eosin (H&E), (B) Masson's trichrome, (C) Al","[79, 1017, 1103, 1100]",figure_caption,0.92,"[""figure_title label: Fig. 6. Histological and immunohistochemical (IHC) analyses ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +10,14,paragraph_title,Total RNA sequencing analysis of epMSCs,"[81, 1138, 478, 1163]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Total RNA sequencing analysis of epMSCs""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +10,15,text,"Total RNA sequencing was performed to explore the mechanisms underlying epMSC-mediated enhancement of chondrogenic differentiation in vitro and cartilage regeneration in vivo. In total, 128 DEGs with ","[79, 1162, 580, 1497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,16,text,"signaling pathway, and cartilage development) were further +extracted (Fig. 7 E).","[604, 1139, 1103, 1184]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,17,text,"The ECM plays a key role in forming a complex network of macromolecules, providing structural support, transducing signals for cellular communication, and regulating cellular behavior through interact","[602, 1184, 1105, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,18,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82, 1531, 451, 1554]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,19,number,10,"[1077, 1531, 1103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,Biomaterials Research,"[847, 61, 1116, 96]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,1,figure_title,A,"[96, 126, 117, 149]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,2,chart,,"[99, 144, 416, 457]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,3,figure_title,B,"[430, 126, 448, 147]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,4,chart,,"[428, 131, 764, 451]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,5,figure_title,C,"[827, 126, 847, 148]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,6,figure_title,D,"[97, 496, 117, 519]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,7,chart,,"[156, 494, 671, 817]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,8,image,,"[822, 128, 1112, 791]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,9,figure_title,E,"[96, 845, 116, 868]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +11,10,chart,,"[198, 834, 951, 1202]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +11,11,figure_title,Fig. 7. Total RNA sequencing of MSCs and epMSCs (n = 3 for each group). (A) Comparison of gene expression as a scatter plot between MSCs and epMSCs. (B) Volcano plot of −log₁₀(P value) versus log₂(fol,"[95, 1219, 1117, 1403]",figure_caption,0.92,"[""figure_title label: Fig. 7. Total RNA sequencing of MSCs and epMSCs (n = 3 for e""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,True,True +11,12,text,"phospholipid scramblase 1 [PLSCR1], fibulin-1 [FBLN1], and podocan-like protein 1 [PODNL1]) were down-regulated, whereas 4 genes (wingless-related integration site [WNT5B], serpin family E member 1 [S","[95, 1425, 594, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +11,13,text,"E member 1 [SERPINE1], type XIII collagen alpha 1 chain +[COL13A1], and semaphorin 7A [SEMA7A]) were up-regulated. +In particular, FBLN1, COL13A1, PODNL1, INHBE, and SOD3","[618, 1425, 1118, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,14,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[96, 1531, 464, 1554]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,15,number,11,"[1096, 1531, 1117, 1553]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +12,0,header,Biomaterials Research,"[833, 62, 1102, 96]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +12,1,text,"contribute to ECM organization, whereas ADAMTS5, CLU, SERPINE1, and WNT5B are involved in ECM remodeling [30–37]. CCN5, PLSCR1, SEMA7A, and WNT2B mediate cell–ECM interactions and signal transduction ","[79, 127, 580, 768]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,2,paragraph_title,Discussion,"[81, 793, 200, 818]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True +12,3,text,"Owing to their unique ability to self-renew, differentiate, and modulate the immune response, MSCs have garnered considerable attention for the cell-based therapy of various tissue diseases, including","[79, 830, 580, 1272]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,4,text,"Our findings indicated that priming MSCs with ES under optimal conditions (0.3 V and 1 Hz) significantly improved the expression of chondrogenic genes and cartilage-specific proteins, including COL2, ","[79, 1271, 579, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,5,text,"in gene expression profiles after ES, particularly in pathways +related to ECM organization, Wnt signaling, and cartilage +development. +ES l di V i d i bl l","[604, 126, 1103, 194]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,6,text,"ES voltages exceeding 0.5 V can trigger undesirable electrochemical reactions within the culture media, leading to alterations in protein structures and disruptions to the cellular microenvironment [2","[603, 194, 1105, 656]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,7,text,"For OCD repair, numerous studies have used MSCs with hydrogels to enhance their applicability and efficacy [53]. In this study, we evaluated the effects of epMSCs using HA, a major ECM component of th","[603, 655, 1104, 1029]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,8,text,"Nanosecond pulsed electric field can affect intracellular signaling pathways by activating c-Jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase, and Wnt signaling [54]. Recently, ","[603, 1030, 1105, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,9,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[82, 1531, 451, 1554]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +12,10,number,12,"[1079, 1531, 1103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +13,0,header,Biomaterials Research,"[848, 62, 1116, 95]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +13,1,text,"growth and repair. DEGs involved in the immune response, cell differentiation, and other related processes suggest that ES can induce the creation of a favorable microenvironment for tissue regenerati","[94, 127, 593, 435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,2,text,"With an aim to improve therapeutic effectiveness of MSCs, we explored preconditioning MSCs with the appropriate ES in vitro to increase their chondrogenic differentiation. Transplantation of epMSCs wi","[94, 435, 593, 701]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,paragraph_title,Acknowledgments,"[96, 733, 288, 760]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,4,text,Funding: This research was supported by the Challengeable Future Defense Technology Research and Development Program through the Agency for Defense Development (ADD) funded by the Defense Acquisition ,"[95, 774, 591, 885]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,text,"Author contributions: J.Y.: methodology, investigation, formal analysis, data curation, writing—original draft and review and editing, software, validation, and visualization. Y.B.: investigation and ","[95, 886, 592, 1061]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,support_like,none,True,True +13,6,text,Competing interests: The authors declare that they have no competing interests.,"[96, 1061, 591, 1107]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,paragraph_title,Data Availability,"[96, 1146, 267, 1174]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data Availability""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,8,text,The data that support the findings of this study are available from the corresponding authors upon reasonable request.,"[95, 1190, 591, 1238]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,9,paragraph_title,Supplementary Materials,"[96, 1267, 358, 1294]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supplementary Materials""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +13,10,text,Figs. S1 to S7 Tables S1 and S2,"[97, 1305, 236, 1350]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,11,paragraph_title,References,"[96, 1378, 216, 1405]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +13,12,reference_content,"1. Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of articular cartilage: Structure, composition, and function. Sports Health. 2009;1(6):461–468.","[107, 1426, 591, 1490]",reference_item,0.85,"[""reference content label: 1. Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of art""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,13,reference_content,"2. Boeuf S, Richter W. Chondrogenesis of mesenchymal stem cells: Role of tissue source and inducing factors. 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Richter A, L\u00fcbbing M, Frank HG, Nolte I, Bullerdiek JC, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +14,33,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[83, 1532, 450, 1554]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +14,34,number,14,"[1080, 1532, 1102, 1552]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,0,header,Biomaterials Research,"[848, 63, 1116, 95]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +15,1,reference_content,derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cells. Eur Cell Mater. 2011;21:355–363.,"[132, 128, 564, 191]",reference_item,0.85,"[""reference content label: derived fragments stimulate the proliferation of chondrocyte""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +15,2,reference_content,"49. Gao Z, Wang Q, Guo K, Li X, Huang Y. 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Nanosecond pulsed electri""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +15,8,footer,Yi et al. 2024 | https://doi.org/10.34133/bmr.0109,"[96, 1531, 464, 1554]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +15,9,number,15,"[1093, 1531, 1117, 1553]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/3FDT9652/block_trace.csv b/tests/fixtures/ocr_real_papers/3FDT9652/block_trace.csv new file mode 100644 index 00000000..097f7d47 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/3FDT9652/block_trace.csv @@ -0,0 +1,249 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[0, 255, 22, 1311]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_main_zone,support_like,none,False,False +1,1,header,Musculoskeletal Imaging • Original Research,"[422, 43, 886, 69]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,doc_title,Predictive Factors of Retear in Patients With Repaired Rotator Cuff Tear on Shoulder MRI,"[423, 285, 1029, 413]",paper_title,0.8,"[""page-1 zone title_zone: Predictive Factors of Retear in Patients With Repaired Rotat""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,"Yun Kyung Shin $ ^{1} $ +Kyung Nam Ryu $ ^{1} $ +Ji Seon Park $ ^{1} $ +Wook Jin $ ^{2} $ +So Young Park $ ^{2} $ +Young Cheol Yoon $ ^{3} $","[74, 453, 233, 601]",authors,0.8,"[""page-1 zone author_zone: Yun Kyung Shin $ ^{1} $\nKyung Nam Ryu $ ^{1} $\nJi Seon Park ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"Keywords: acromiohumeral interval, MRI, retear, retraction, rotator cuff, shoulder","[73, 900, 357, 941]",frontmatter_noise,0.7,"[""keyword-like block: Keywords: acromiohumeral interval, MRI, retear, retraction, ""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,5,text,doi.org/10.2214/AJR.17.17915,"[74, 954, 247, 976]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,6,text,"Received January 5, 2017; accepted after revision May 23, 2017.","[73, 991, 362, 1030]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received January 5, 2017; accepted after revision May 23, 20""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,7,text," $ ^{1} $Department of Radiology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Address correspondence to","[74, 1046, 378, 1140]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: $ ^{1} $Department of Radiology, Kyung Hee University Hospit""]",frontmatter_noise,0.8,body_zone,body_like,affiliation_marker,False,False +1,8,text," $ ^{2} $Department of Radiology, Kyung Hee University Hospital at Gandong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.","[73, 1153, 404, 1212]",frontmatter_noise,0.85,"[""affiliation block: $ ^{2} $Department of Radiology, Kyung Hee University Hospit""]",frontmatter_noise,0.85,body_zone,body_like,affiliation_marker,False,False +1,9,text," $ ^{3} $Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.","[73, 1226, 383, 1283]",frontmatter_noise,0.85,"[""affiliation block: $ ^{3} $Department of Radiology, Samsung Medical Center, Sun""]",frontmatter_noise,0.85,body_zone,body_like,affiliation_marker,False,False +1,10,text,This article is available for credit.,"[74, 1298, 268, 1318]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,text,AJR2018:210:134–141,"[75, 1334, 208, 1355]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,short_fragment,False,False +1,12,text,0361-803X/18/2101-134,"[75, 1369, 220, 1390]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,13,text,"© American Roentgen Ray Society + +OBJECTIVE. This study aimed to find independent prognostic factors related to retear of the rotator cuff tendon in patients with repaired full-thickness supraspinatus ","[75, 1406, 278, 1427]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 American Roentgen Ray Society\n\nOBJECTIVE. This study aimed""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,14,text,"OBJECTIVE. This study aimed to find independent prognostic factors related to retear of +the rotator cuff tendon in patients with repaired full-thickness supraspinatus tendon tear by +evaluation of pre-","[419, 455, 1103, 522]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,text,MATERIALS AND METHODS. Shoulder MR images were retrospectively analyzed for 83 patients who had undergone arthroscopic or open rotator cuff repair with acromioplasty for full-thickness supraspinatus t,"[420, 522, 1103, 721]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,text,"RESULTS. The overall retear rate was 57.8%. Significant differences were observed between the retear and intact groups in terms of the mean values of the extent of tendon retraction (20.4 vs 11.7 mm),","[420, 721, 1102, 940]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,text,CONCLUSION. The retear rate of repaired rotator cuff tendon was about 57.8%. Independent prognostic factors of retear were degree of tendon retraction and AHI on preoperative MR images.,"[420, 941, 1101, 1007]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,18,image,,"[427, 1035, 503, 1114]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +1,19,text,"otator cuff tear is a common cause of shoulder joint pain, and MRI has high sensitivity and specificity in the diagnosis of rotator cuff tears [1]. Retear after rotator cuff repair is relatively commo","[509, 1032, 754, 1121]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,20,text,"specificity in the diagnosis of ro +tator cuff tears [1]. Retear after rotator cuff +repair is relatively common, and reports on +its frequency vary from 13% to 84% [2, 3]. +More fatty infiltration of the","[421, 1122, 754, 1297]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,21,text,"Although it is generally thought that there is no relationship between retear after surgical repair and poor functional outcomes [3], there have been previous published reports implying that postopera","[421, 1297, 754, 1431]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,22,text,"with a successful structural integrity [13, 14]. +Bias may intervene in postoperative follow-up +evaluation of functional outcomes, with meth- +ods such as visual analog scale or muscular +strength making","[769, 1030, 1103, 1253]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,23,text,"Various imaging modalities can be used for a radiologic evaluation of rotator cuff re-tear after surgical repair. Arthrography, sonography, CT, and MRI are used for diagnosis of retear of rotator cuff","[769, 1254, 1102, 1384]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,24,text,Although there have been numerous reports on the factors associated with rotator cuff re-,"[770, 1385, 1103, 1430]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,25,number,134,"[76, 1480, 104, 1498]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +1,26,footer,"AJR:210, January 2018","[946, 1479, 1101, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[0, 259, 22, 1308]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +2,1,header,Retear of Repaired Rotator Cuff Tear Seen at MRI,"[400, 93, 836, 114]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,image,,"[108, 143, 432, 468]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,3,image,,"[455, 145, 781, 466]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,4,figure_title,"Fig. 1—Two patients with full-thickness tears of supraspinatus tendon. +A, 73-year-old man with full-thickness full-width tear of supraspinatus tendon. Preoperative T2-weighted oblique sagittal MR imag","[104, 497, 783, 583]",figure_caption,0.92,"[""figure_title label: Fig. 1\u2014Two patients with full-thickness tears of supraspinat""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,5,text,"tear, there were only few reports in the English literature that included multivariable analyses of independent prognostic factors using preoperative MRI findings [16]. Therefore, the purpose of this ","[103, 604, 435, 803]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,paragraph_title,"Materials and Methods +Patients","[104, 823, 307, 866]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Materials and Methods\nPatients""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +2,7,text,"This study was approved by the institutional review board of Kyung Hee University Hospital, and the requirement for informed consent was waived. A retrospective review was done of medical records and ","[102, 871, 436, 1241]",affiliation,0.8,"[""page-1 zone affiliation_zone: This study was approved by the institutional review board of""]",affiliation,0.8,body_zone,body_like,none,True,True +2,8,text,"The exclusion criteria were as follows: concomitant infraspinatus tear that is separated from supraspinatus tear, lack of preoperative shoulder MRI or lack of postoperative shoulder MRI performed more","[102, 1244, 436, 1418]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"concomitant tenodesis of long head of biceps bra- +chii tendon, revision surgery because of additional +trauma, concomitant acromioclavicular resection, +and poor image quality. Of 316 patients, 83 were +","[451, 604, 784, 711]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,"The mean age at operation was 61.2 years (range, 44–75 years). There were 28 men and 55 women.","[451, 713, 783, 756]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,paragraph_title,MRI Examinations,"[453, 778, 588, 798]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: MRI Examinations""]",subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,False,True +2,12,text,"The mean time between preoperative MRI to operation was 17.2 days (range, 0–86 days). The mean time between operation to follow-up MRI (mean follow-up period, excluding MR images taken immediately aft","[451, 802, 784, 931]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,text,"A 3-T imaging unit (Achieva, Philips Healthcare) equipped with a dedicated shoulder coil (4-channel SENSE shoulder coil, Philips Healthcare) was used to obtain the MR images. The sequences and paramet","[449, 934, 784, 1417]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,text,"gap, 0.5 mm), and oblique sagittal turbo spin-echo +T2-weighted (FOV, 140 × 140 mm; TR/TE, 5400– +6000/80; matrix, 328 × 240; section thickness, 2.0 +mm; and intersection gap, 0.5 mm).","[800, 142, 1132, 227]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,text,"The sequences and parameters of the postoperative MRI were as follows: axial turbo spin-echo T2-weighted (FOV, 140 × 140 mm; TR/TE, 3800/80; matrix, 256 × 255; section thickness, 2.0 mm; and intersect","[799, 231, 1133, 580]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,16,paragraph_title,MR Image Interpretation,"[800, 602, 981, 623]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: MR Image Interpretation""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,False,True +2,17,text,"At preoperative MRI, type of the supraspinatus tendon tear, extent of retraction of the torn tendon (full-thickness full-width or full-thickness partial-width tear), anteroposterior (AP) dimension of ","[799, 626, 1132, 799]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,18,text,Two radiologists with 30 and 5 years of experience in musculoskeletal imaging participated in the interpretation of preoperative and postoperative MR images of 83 patients. The junior radiologist meas,"[799, 802, 1133, 1063]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,19,text,Full-thickness full-width tear of the supraspinatus tendon was defined as a complete detachment of the supraspinatus tendon from the humeral head on oblique sagittal T2-weighted images (Fig. 1A). Tear,"[798, 1066, 1133, 1418]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,20,footer,"AJR:210, January 2018","[105, 1479, 261, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,21,number,135,"[1104, 1481, 1132, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[1, 260, 22, 1310]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +3,1,header,Shin et al.,"[543, 93, 633, 114]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,image,,"[79, 142, 402, 468]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,Fig. 2—58-year-old woman with rotator cuff tear. Extent of retraction (bidirectional arrow) was measured as maximum medial-to-lateral length on preoperative T2-weighted oblique coronal MR image.,"[73, 490, 402, 560]",figure_caption,0.92,"[""figure_title label: Fig. 2\u201458-year-old woman with rotator cuff tear. Extent of r""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,spinatus portion of the tear was included in the measurement (Fig. 3). The signal intensity of the tear edge was classified into three categories on oblique coronal T2-weighted MR images (Fig. 4): typ,"[73, 581, 406, 999]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,image,,"[425, 143, 752, 468]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,Fig. 3—59-year-old woman with rotator cuff tear. Anteroposterior (AP) dimension of tear (bidirectional arrow) was measured as maximum AP dimension of tear on preoperative T2-weighted oblique sagittal ,"[421, 490, 746, 611]",figure_caption,0.92,"[""figure_title label: Fig. 3\u201459-year-old woman with rotator cuff tear. Anteroposte""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,7,text,native because our institution's routine protocol did not include sagittal T1-weighted images. AHI was measured as the minimum length between the acromion and humeral head on oblique sagittal T2-weigh,"[421, 625, 754, 778]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"Postoperative cuff integrity was classified into five categories according to the system of Sugaya et al. [18] using oblique coronal and oblique sagittal T2-weighted MR images: type I, repaired cuff a","[421, 780, 754, 999]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"compared with normal cuff, but without disconti- +nuity, suggesting a partial-thickness delaminated +tear; type IV, presence of a minor discontinuity in +only one or two slices on both oblique coronal an","[769, 142, 1102, 361]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,paragraph_title,Statistical Analysis,"[771, 382, 904, 402]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical Analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,11,text,All continuous variables were tested for normality with the Kolmogorov-Smirnov and Shapiro-Wilk tests. Measurements were expressed as mean ± SD with 95% CIs for continuous variables that accepted norm,"[768, 406, 1103, 867]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,paragraph_title,Results,"[771, 887, 841, 908]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,13,text,"Retear Rate of Repaired Rotator Cuff +According to Sugaya Classification","[770, 910, 1036, 953]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,text,"According to the classification scheme by Sugaya et al. [18], the repaired supraspinatus","[770, 954, 1101, 999]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,image,,"[77, 1021, 402, 1344]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,16,image,,"[425, 1020, 752, 1345]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,17,image,,"[774, 1022, 1099, 1343]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,18,vision_footnote,Fig. 4—Signal intensity of tear edge on preoperative T2-weighted oblique coronal MR images.,"[74, 1372, 650, 1391]",figure_caption,0.9,"[""figure prefix matched: Fig. 4\u2014Signal intensity of tear edge on preoperative T2-weig""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +3,19,vision_footnote,"A, 62-year-old man with type I tear. Tear edge (arrowhead) of supraspinatus tendon shows same low signal intensity as normal tendon.","[73, 1389, 889, 1407]",footnote,0.7,"[""vision_footnote label: A, 62-year-old man with type I tear. Tear edge (arrowhead) o""]",footnote,0.7,body_zone,body_like,none,True,True +3,20,vision_footnote,B. 74-year-old woman with type II tear. Tear edge (arrowhead) of supraspinatus tendon shows intermediate signal intensity.,"[74, 1407, 827, 1422]",footnote,0.7,"[""vision_footnote label: B. 74-year-old woman with type II tear. Tear edge (arrowhead""]",footnote,0.7,body_zone,body_like,none,True,True +3,21,vision_footnote,C. 67-year-old woman with type III tear. Tear edge (arrowhead) of supraspinatus tendon shows high signal intensity similar to fatty bone marrow of humeral head.,"[73, 1423, 1050, 1442]",footnote,0.7,"[""vision_footnote label: C. 67-year-old woman with type III tear. Tear edge (arrowhea""]",footnote,0.7,body_zone,body_like,none,True,True +3,22,number,136,"[76, 1481, 104, 1498]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,23,footer,"AJR:210, January 2018","[946, 1479, 1101, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[0, 253, 22, 1311]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +4,1,header,Retear of Repaired Rotator Cuff Tear Seen at MRI,"[399, 92, 837, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,figure_title,TABLE I: Classification of Rotator Cuff Integrity Seen at MRI After Surgery,"[104, 139, 426, 202]",figure_caption_candidate,0.85,"[""figure_title label: TABLE I: Classification of Rotator Cuff Integrity Seen at MR""]",figure_caption,0.85,body_zone,table_caption_like,none,False,False +4,3,table,
GroupImplanted materialImplanted cells
ControlNo materialNo cells
HA-only2% HANo cells
,"[105, 208, 432, 423]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,4,vision_footnote,Note—Rotator cuff integrity was classified according to the system published by Sugaya et al. [18].,"[113, 427, 434, 465]",footnote,0.7,"[""vision_footnote label: Note\u2014Rotator cuff integrity was classified according to the ""]",footnote,0.7,body_zone,body_like,none,True,True +4,5,text,"tendon on 83 postoperative MR images was type I in two (2.4%) patients, type II in 19 (22.9%) patients, type III in 14 (16.9%) patients, type IV in 10 (12.0%) patients, and type V in 38 (45.8%) patien","[101, 493, 437, 737]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Comparison of Demographics and Preoperative Radiologic Findings Between the Intact and Retear Groups,"[103, 757, 426, 824]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Comparison of Demographics and Preoperative Radiologic Findi""]",subsection_heading,0.6,body_zone,body_like,none,True,True +4,7,footer,,"[103, 775, 426, 824]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,8,text,The mean age at the time of surgery was $ 59.6 \pm 7.1 $ years in the intact group and $ 62.4 \pm 5.9 $ years in the retear group. There was no statistically significant difference between the two g,"[103, 825, 436, 936]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,image,,"[103, 959, 436, 1294]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,10,figure_title,Fig. 5—60-year-old woman with full-thickness tear of supraspinatus tendon. Acromiohumeral interval (bidirectional arrow) was measured as minimum length between acromion and humeral head (parallel line,"[102, 1313, 430, 1418]",figure_caption,0.92,"[""figure_title label: Fig. 5\u201460-year-old woman with full-thickness tear of suprasp""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,11,text,"There were 13 men and 22 women in the intact group, and there were 15 men and 33 women in the retear group. There was no statistically significant difference in the sex ratio of the two groups $ (p =","[450, 141, 783, 251]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,"The preoperative mean extent of tendon retraction was $ 20.4 \pm 9.7 $ mm (range, 5.8–48.0 mm) in the retear group and $ 11.7 \pm 8.1 $ mm (range, 1.7–31.0) in the intact group. The preoperative mea","[450, 252, 784, 427]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,text,"There was a significant difference in the degree of fat infiltration of the supraspinatus muscle between the intact and retear groups (p = 0.034). Also, there was a significant difference in the degre","[451, 427, 785, 560]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,14,text,"retear groups (p = 0.023). The preoperative +mean AP dimension of tear was 16.1 ± 8.6 mm +(range, 2.6–42.9 mm) in the retear group and +11.4 ± 9.9 mm (range, 2.2–44.0) in the intact +group. The mean AP di","[798, 142, 1134, 404]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,15,text,"There was a significant difference in the degree of fat infiltration of the supraspinatus muscle between the intact and retear groups $ (p=0.034) $. Also, there was a significant difference in the de","[798, 406, 1133, 561]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,16,figure_title,TABLE 2: Comparison of Demographics and Preoperative Radiologic Findings Between the Intact and Retear Groups,"[451, 588, 1129, 630]",table_caption,0.9,"[""table prefix matched: TABLE 2: Comparison of Demographics and Preoperative Radiolo""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,17,table,"
Sugaya ClassificationNo. (%) of Patients ( $ n = 83 $)
I2 (2.4)
II19 (22.9)
III14 (16.9)
VariableIntact Group (n = 35)Retear Group (n = 48)p $ ^{a} $
Age (y), mean $ \pm $ SD (range)59.6 $ \pm $ 7.1 (44-73)62.4","[456, 636, 1123, 1355]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,18,vision_footnote,"Note—Except where noted otherwise, data are number of patients.","[461, 1361, 872, 1380]",footnote,0.7,"[""vision_footnote label: Note\u2014Except where noted otherwise, data are number of patien""]",footnote,0.7,body_zone,body_like,none,True,True +4,19,vision_footnote,Values shown in bold type are statistically significant.,"[460, 1379, 795, 1397]",footnote,0.7,"[""vision_footnote label: Values shown in bold type are statistically significant.""]",footnote,0.7,body_zone,body_like,none,True,True +4,20,vision_footnote, $ ^{b} $Goutallier classification system was used [7].,"[461, 1396, 744, 1416]",footnote,0.7,"[""vision_footnote label: $ ^{b} $Goutallier classification system was used [7].""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +4,21,footer,"AJR:210, January 2018","[105, 1479, 261, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,22,number,137,"[1104, 1480, 1131, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[0, 252, 22, 1308]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +5,1,header,Shin et al.,"[542, 92, 634, 114]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,text,"The mean AHI at preoperative MRI was $ 6.8 \pm 2.1 $ mm (range, 1.6–10.4 mm) in the retear group and $ 8.7 \pm 1.2 $ mm (range, 5.0–10.47 mm) in the intact group. The mean AHI at preoperative MRI wa","[72, 141, 406, 297]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,text,"There were no statistically significant differences in the type of tear and signal intensity of tear edge between the intact and retear groups (p = 0.180 and 0.185, respectively). Table 2 shows specif","[72, 296, 406, 429]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,paragraph_title,Univariable Analysis of Radiologic Finding Associated With Retear of Repaired Rotator Cuff,"[72, 450, 407, 493]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Univariable Analysis of Radiologic Finding Associated With R""]",subsection_heading,0.6,body_zone,body_like,none,True,True +5,5,footer,,"[72, 471, 407, 493]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +5,6,text,"On univariable analysis, there were no statistically significant differences between the retear and intact groups in terms of patient age or sex, type of tear (full-thickness partial-width vs full-thi","[72, 495, 406, 779]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,The retear rate of the supraspinatus tendon was significantly higher in patients with higher fat infiltration of the supraspinatus $ (p = 0.049) $ and infraspinatus muscles $ (p = 0.045) $. Supraspi,"[72, 780, 408, 1001]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,figure_title,TABLE 3: Univariable Analysis of Radiologic Finding Associated With Retear of Repaired Rotator Cuff,"[420, 138, 1090, 183]",table_caption,0.9,"[""table prefix matched: TABLE 3: Univariable Analysis of Radiologic Finding Associat""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,9,table,
VariableOdds Ratio (95% CI)p $ ^{a} $
Sex1.069 (0.996-1.147)0.064
Age1.300 (0.519-3.255)0.575
Variable $ ^{a} $Odds Ratio (95% CI)p $ ^{b} $
Tendon retraction1.092 (1.006-1.185)0.036
Anteroposterior dimension<,"[453, 988, 1129, 1353]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,17,vision_footnote, $ ^{a} $The variables were adjusted according to patient age and sex.,"[459, 1357, 841, 1377]",footnote,0.7,"[""vision_footnote label: $ ^{a} $The variables were adjusted according to patient age""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +6,18,vision_footnote,Values shown in bold type are statistically significant.,"[459, 1376, 795, 1393]",footnote,0.7,"[""vision_footnote label: Values shown in bold type are statistically significant.""]",footnote,0.7,body_zone,body_like,none,True,True +6,19,vision_footnote, $ ^{c} $Goutallier classification was used [7].,"[460, 1393, 698, 1412]",footnote,0.7,"[""vision_footnote label: $ ^{c} $Goutallier classification was used [7].""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +6,20,footer,"AJR:210, January 2018","[105, 1479, 261, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,21,number,139,"[1104, 1480, 1132, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,aside_text,Downloaded from www.ajronline.org by 23.132.124.130 on 01/13/26 from IP address 23.132.124.130. Copyright ARRS. For personal use only; all rights reserved,"[0, 258, 22, 1309]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +7,1,header,Shin et al.,"[542, 92, 633, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,tears. Such cases suggest that there would be important factors other than AP dimension of tear that affect tendon integrity after repair.,"[72, 142, 405, 207]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"In this study, preoperative AHI was proven to be an independent predictive factor related to retear. To our knowledge, there has been no multivariable analysis that used MRI to study the relationship ","[73, 209, 407, 1130]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,4,text,"In the current study, we could not conclude that the degree of fat infiltration in the supraspinatus and infraspinatus muscles is an independent prognostic factor that affects retear. A greater degree","[72, 1132, 407, 1420]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,5,text,"fraspinatus muscles is related to retear. How- +ever, it was not a significant prognostic fac- +tor of retear in multivariable analysis. There +may be two possible reasons for such a re- +sult. First, the","[420, 143, 754, 646]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"In this study, the signal intensity of tear edge at preoperative MRI was not significantly related to retear. The signal intensity on T2-weighted images increases because of the edema and hemorrhage t","[420, 648, 755, 1065]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,7,text,"There are some limitations to this study. First, it is a retrospective study. Second, the mean follow-up period after surgery was relatively short (312.4 days; range, 251–435 days). Further long-term ","[419, 1066, 755, 1419]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,8,text,"functional outcomes [16, 32, 33]. Further- +more, potential bias may arise in the evalu- +ation of postoperative functional outcome, +which can cause an overestimation in the +degree of improvement. Becau","[768, 143, 1104, 669]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"In conclusion, the retear rate after surgical repair of supraspinatus full-thickness tendon tear is 57.8%. Preoperative degree of tendon retraction and AHI are independent prognostic factors of retear","[768, 670, 1103, 826]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,paragraph_title,References,"[771, 846, 873, 866]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +7,11,reference_content,"1. Lenza M, Buchbinder R, Takwoingi Y, Johnston RV, Hanchard NCA, Faloppa F. 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Arthroscopic re""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,30,reference_content,"32. Boileau P, Brassart N, Watkinson DJ, Carles M, Hatzidakis AM, Krishnan SG. Arthroscopic repair of full-thickness tears of the supraspinatus: does the tendon really heal? J Bone Joint Surg Am 2005;","[804, 825, 1131, 929]",reference_item,0.85,"[""reference content label: 32. Boileau P, Brassart N, Watkinson DJ, Carles M, Hatzidaki""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,31,reference_content,"33. Liu SH, Baker CL. Arthroscopically assisted rotator cuff repair: correlation of functional results with integrity of the cuff. Arthroscopy 1994; 10:54–60","[804, 936, 1131, 1017]",reference_item,0.85,"[""reference content label: 33. Liu SH, Baker CL. Arthroscopically assisted rotator cuff""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True +8,32,text,FOR YOUR INFORMATION,"[148, 1073, 421, 1093]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,33,text,"This article is available for CME and Self-Assessment (SA-CME) credit that satisfies Part II requirements for maintenance of certification (MOC). To access the examination for this article, follow the","[145, 1103, 1077, 1171]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +8,34,footer,"AJR:210, January 2018","[106, 1480, 261, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,35,number,141,"[1105, 1481, 1130, 1498]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/3IL2JIHZ/block_trace.csv b/tests/fixtures/ocr_real_papers/3IL2JIHZ/block_trace.csv new file mode 100644 index 00000000..160bf6cd --- /dev/null +++ b/tests/fixtures/ocr_real_papers/3IL2JIHZ/block_trace.csv @@ -0,0 +1,197 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,doc_title,In Vivo Effect of Two Different Pulsed Electromagnetic Field Frequencies on Osteoarthritis,"[109, 63, 958, 137]",paper_title,0.8,"[""page-1 zone title_zone: In Vivo Effect of Two Different Pulsed Electromagnetic Field""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,1,text,"F. Veronesi, $ ^{1} $ P. Torricelli, $ ^{1,2} $ G. Giavaresi, $ ^{1,2} $ M. Sartori, $ ^{2} $ F. Cavani, $ ^{3} $ S. Setti, $ ^{4} $ M. Cadossi, $ ^{5} $ A. Ongaro. $ ^{6} $ M. Fini $ ^{1,2} $","[107, 170, 1010, 195]",frontmatter_noise,0.7,"[""keyword-like block: F. Veronesi, $ ^{1} $ P. Torricelli, $ ^{1,2} $ G. Giavaresi""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,2,text," $ ^{1} $Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute-IOR, via Di Barbiano 1/10 40136, Bologna, Italy, $ ^{2} $Department Rizzoli RIT, Rizzoli Orthopedic Institute-IOR","[107, 207, 1120, 329]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $Laboratory of Preclinical and Surgical Studies, Rizz""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,3,text,Received 5 February 2013; accepted 6 January 2014,"[109, 337, 477, 357]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received 5 February 2013; accepted 6 January 2014""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,4,text,Published online 5 February 2014 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/jor.22584,"[108, 357, 864, 377]",frontmatter_noise,0.7,"[""frontmatter noise text: Published online 5 February 2014 in Wiley Online Library (wi""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,5,abstract,"ABSTRACT: Osteoarthritis (OA) is a joint pathology characterized by fibrillation, reduced cartilage thickness and subchondral bone sclerosis. There is evidence that pulsed electromagnetic fields (PEMF","[108, 389, 1121, 610]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,6,text,Keywords: pulsed electromagnetic fields; osteoarthritis; PEMF frequencies,"[108, 624, 691, 646]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: pulsed electromagnetic fields; osteoarthritis; PEM""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,7,text,"Articular cartilage is a connective tissue not able to repair itself, because of its avascular, anerural and alymphatic structure and poor chondrocyte mitotic ability. $ ^{1} $ For these reasons, high","[107, 692, 601, 1198]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,"Several in vitro and in vivo studies and very few clinical trials were performed to assess the effect of PEMF stimulation in cartilage, but only few authors investigated PEMFs in OA pathology, and the","[107, 1198, 602, 1361]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,text,"analysis of high-quality trials suggests that PEMFs +are effective in treating pain and improving function +in OA at 8 weeks after treatment initiation.6 However, +no specific considerations were posited ","[625, 693, 1120, 831]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,10,text,"Regarding in vitro works, the majority of authors extensively observed the positive effects of PEMFs in chondrocytes, fibroblasts and cartilage explants all with a frequency of 75 Hz and a magnetic fl","[624, 832, 1121, 1477]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,footnote,"Grant sponsor: Monte Paschi di Siena Foundation. +Correspondence to: Francesca Veronesi (T: +39 051 6366005; F: +39 0516366580; E-mail: francesca.veronesi@ior.it) +© 2014 Orthopaedic Research Society. P","[107, 1393, 594, 1474]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Grant sponsor: Monte Paschi di Siena Foundation.\nCorresponde""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,12,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[718, 1504, 1055, 1523]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,13,number,677,"[1083, 1502, 1119, 1522]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,0,number,678,"[69, 68, 105, 87]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,VERONESI ET AL.,"[134, 68, 286, 88]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,text,"authors that stimulated OA chondrocytes cultured alone $ ^{19} $ or on type-I collagen scaffold $ ^{20} $ with PEMFs at 16.7 Hz $ ^{20} $ or 21.2 MHz, $ ^{19} $ with no improvement in ECM component sy","[64, 117, 558, 209]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,Most in vivo preclinical studies applied PEMF at 75 Hz of frequency and involved bone and osteochondral defect regeneration. PEMF stimulation produced beneficial effects in bone morphology and structu,"[65, 209, 561, 713]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Finally, regarding PEMF pulse frequency, 75 Hz was usually well tolerated by patients that underwent arthroscopic treatment for cartilage lesions, anterior cruciate ligament reconstruction or early sp","[65, 713, 559, 896]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"It is noteworthy that no previous in vitro and in vivo studies, dealing with PEMF stimulation in OA, took into account that different PEMF frequencies might produce different biological effects. For t","[65, 897, 560, 1194]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"After 3 months of PEMF stimulation (6h/day), medial and lateral tibial plateaus and femoral condyles were evaluated by histological and histomorphometric analyses of both cartilage and subchondral bon","[64, 1194, 559, 1312]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,MATERIALS AND METHODS Animals and Study Design,"[66, 1344, 347, 1390]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: MATERIALS AND METHODS Animals and Study Design""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,8,footer,,"[66, 1369, 273, 1390]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,9,text,"The study was performed according to European and Italian legislation on animal experimentation (Law by Decree January 27, 1992, No. 116). Fifteen Dunkin Hartley guinea pigs (Charles River, Calco, Lec","[65, 1388, 560, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,text,"housed individually in Plexiglas cages (40 cm 25 cm 18 +cm) under controlled conditions (room temperature +22 0.5˚C; relative humidity 55 5%; 12 h of light and 12 h +of darkness) and were supplied with s","[583, 118, 1081, 582]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,paragraph_title,PEMF Characteristics,"[585, 600, 754, 621]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: PEMF Characteristics""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +2,12,text,"In the PEMF-treated groups, electromagnetic stimulators (IGEA SpA, Carpi, Modena, Italy) delivered PEMFs with a magnetic field intensity peak of 1.5 mT and a duty cycle of 1.3 ms, but with two differe","[583, 621, 1080, 1063]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,paragraph_title,Sample Processing for Histological and Histomorphometric Evaluations,"[583, 1095, 1037, 1137]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Sample Processing for Histological and Histomorphometric Eva""]",subsection_heading,0.6,body_zone,body_like,none,True,True +2,14,text,"After euthanasia, the right and left knee joints of each animal, were fixed in 4% paraformaldehyde for 48 h for histological undecalcified processing and embedded in methylmetacrilate (Merck, Schuchar","[582, 1139, 1080, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[66, 1504, 405, 1523]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,header,PEMF FREQUENCY RESPONSE IN OA,"[739, 68, 1055, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,679,"[1083, 68, 1118, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,"prising medial and lateral tibial plateaus and medial and lateral femoral condyles, were analyzed by histological and histomorphometric evaluations, by two independent researchers, who have experience","[107, 119, 600, 224]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,The Mankin modified by Carlson semi-quantitative histological score $ ^{30} $ was used for chondropathy evaluation of each femoral condyle (medial and lateral) and tibial plateau (medial and lateral) ,"[107, 224, 602, 727]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,"Finally, to evaluate the static histomorphometric parameters of epiphyseal trabecular bone at a magnification of 20×, two consecutive regions of interest (ROIs) of the same area (2,217,224 μm²) were s","[106, 726, 602, 937]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,"-BV/TV: was calculated as $ [(B.Ar/T.Ar) \times (4/\pi) \times 100] $, where B.Ar represents the trabecular bone area and T.Ar the ROI area;","[122, 946, 600, 1009]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"-Tb.Th: was calculated as $ [(2 \times \mathrm{B.Ar})/(\mathrm{B.Pm} \times 4/\pi)] $, where B.Pm is the trabecular bone perimeter;","[127, 1011, 600, 1051]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,-Tb.N: represents the number of the trabeculae per unit area and was calculated as $ [(BV/TV \times 10)/Tb.Th] $;,"[124, 1053, 599, 1094]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"-Tb.Sp: was calculated as $ [(1,000/\text{TbN}) - \text{Tb.Th}] $.","[124, 1092, 514, 1115]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,The area and perimeter values derived from the binarization process of the imaging analysis system inside the ROIs.,"[108, 1138, 598, 1181]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"The inter-tester coefficients for these histomorphometric parameters were 0.84 for BV/TV, 0.82 for Tb.Th, 0.78 for Tb.N and 0.79 for Tb.Sp as also performed by Chiba et al. $ ^{33} $","[108, 1181, 599, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,Statistical Analysis,"[109, 1266, 255, 1286]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical Analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,12,text,"Statistical analysis was performed using the SPSS v. 12.0 software (SPSS, Inc., Chicago, IL). Data are reported as the mean ± SD at a significance level of p < 0.05. After testing data for normal dist","[106, 1286, 602, 1477]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,text,"the histomorphometric data. When such interaction was +significant, univariate ANOVA was performed to investigate +the effects of the treatment and/or measurement site on the +data by hypotheses expressed","[625, 119, 1121, 310]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,paragraph_title,RESULTS,"[629, 326, 720, 349]",section_heading,0.9,"[""explicit scholarly heading: RESULTS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,15,text,Histological images of medial femoral and tibial plateau showed the presence of increased cartilage surface degeneration in the SHAM group in comparison to the two PEMF treated groups (Fig. 1A–F). A s,"[624, 353, 1120, 719]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,16,text,"In the medial tibial plateau, the PEMF-treated at 75 Hz group showed a significantly $ (p < 0.0005) $ lower histological grading score than that of the PEMF-treated at 37 Hz group and SHAM-group, and","[626, 720, 1121, 994]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,17,text,"The FI value was significantly reduced by PEMFs versus control $ (p < 0.0005) $ in the medial tibial plateau, as reported in Table 2. The FI values, achieved in the medial tibial plateau, differed si","[626, 994, 1120, 1154]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,18,text,"Both PEMF treatments significantly reduced the SBT in almost all the knee areas, in comparison with the control group $ (p<0.0005; $ Table 3 $. In the control group, the medial femoral condyle showed","[626, 1152, 1120, 1314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,19,text,"Cartilage thickness did not show interaction between treatment and site factors (Table 4) and, PEMFs at 75Hz significantly maintained cartilage thickness in comparison with either the SHAM group (p < ","[626, 1315, 1120, 1477]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,20,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[783, 1504, 1119, 1522]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,number,680,"[69, 68, 105, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,VERONESI ET AL.,"[135, 68, 286, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,figure_title,A,"[189, 122, 213, 146]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,3,image,,"[186, 147, 563, 431]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,4,figure_title,B,"[588, 122, 610, 144]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,5,image,,"[582, 147, 957, 431]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,6,figure_title,C,"[189, 439, 212, 462]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,7,image,,"[187, 467, 564, 749]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,8,figure_title,D,"[588, 439, 610, 463]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,9,image,,"[582, 467, 957, 748]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,10,figure_title,E,"[190, 757, 211, 780]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,11,figure_title,F,"[585, 757, 607, 781]",figure_inner_text,0.9,"[""panel label / figure inner text: F""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,12,image,,"[187, 785, 563, 1067]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,13,image,,"[581, 785, 957, 1067]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,14,figure_title,"Figure 1. (A and B) Images of cartilage structure of the SHAM-treated group. High fibrillation, reduced staining and cartilage thickness were observed; (A) medial tibial plateau and femoral condyle st","[65, 1082, 1080, 1233]",figure_caption,0.92,"[""figure_title label: Figure 1. (A and B) Images of cartilage structure of the SHA""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,15,text,observed in the medial tibial plateau than in all the other sites $ (p<0.0005) $ and in the lateral tibial plateau in comparison with the medial femoral condyle $ (p<0.005) $ and lateral femoral con,"[64, 1291, 558, 1383]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,16,text,"Regarding the histomorphometric results of epiphyseal femoral and tibial bone (Table 5), an interaction between site and treatment was not observed and PEMF treatments did not affect the BV/TV paramet","[66, 1383, 559, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,17,text,"in all groups. Nevertheless, each medial compartment +had significantly higher values than the lateral ones +(p ¼ 0.001). Both treatments significantly increased Tb. +Th in comparison with the SHAM group (","[583, 1289, 1079, 1476]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,18,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[67, 1504, 404, 1523]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,header,PEMF FREQUENCY RESPONSE IN OA,"[740, 67, 1056, 89]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,681,"[1083, 68, 1118, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,figure_title,"Table 1. Cartilage Histological Score (Mankin Modified by Carlson) Results of Sham-Treated and PEMF-Treated at 37 and 75 Hz Groups at Four Measurement Sites (Mean ± SD, n = 10)","[108, 116, 1119, 163]",table_caption,0.9,"[""table prefix matched: Table 1. Cartilage Histological Score (Mankin Modified by Ca""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,3,table,
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz
Medial tibial plateau$ 9.8 \pm 1.1 $$ 9.7 \pm 0.8 $ $ ^{a} $
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz
Medial tibial plateau$ 217 \pm 11^{a} $$ 189 \pm 14^{b,c} $","[107, 1026, 1117, 1159]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,11,vision_footnote,Univariate ANOVA test. $ ^{a} $Medial tibial plateau versus other sites $ (p<0.0005) $. $ ^{b} $PEMF-treated at 37 Hz and PEMF-treated at 75 Hz versus Sham-treated $ (p<0.0005) $. $ ^{c} $PEMF-treat,"[108, 1162, 1122, 1203]",footnote,0.7,"[""vision_footnote label: Univariate ANOVA test. $ ^{a} $Medial tibial plateau versus ""]",footnote,0.7,body_zone,body_like,none,True,True +5,12,figure_title,"Table 3. Subchondral Bone Thickness (SBT) Results of Sham-Treated and PEMF-Treated at 37 and 75 Hz Groups at Four Measurement Sites (Mean ± SD, n = 10)","[107, 1247, 1119, 1293]",table_caption,0.9,"[""table prefix matched: Table 3. Subchondral Bone Thickness (SBT) Results of Sham-Tr""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,13,table,
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz
Medial tibial plateau447 $ \pm $ 11328 $ \pm $ 52 $ ^{b} $
Sham-TreatedPEMF-Treated at 37 HzPEMF-Treated at 75 Hz $ ^{a,b} $
Medial tibial plateau $ ^{c} $270 $ \pm $ 5297 $ \pm $ ","[65, 170, 1075, 304]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,vision_footnote,Multiple comparison Bonferroni's test. $ ^{a} $PEMF-treated at 75 Hz versus Sham-treated $ (p<0.0005) $. $ ^{b} $PEMF-treated at 75 Hz versus PEMF-treated at 37 Hz $ (p=0.001) $. $ ^{c} $Medial tibi,"[66, 304, 1079, 366]",footnote,0.7,"[""vision_footnote label: Multiple comparison Bonferroni's test. $ ^{a} $PEMF-treated ""]",footnote,0.7,body_zone,body_like,none,True,True +6,5,text,"this frequency preserves the cartilage from the progressive reduction of its thickness, which is typical of OA. Conversely, at 37 Hz, PEMFs did not significantly affect cartilage thickness. These find","[64, 415, 560, 576]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,text,"Regarding bone, in the present work, both PEMF frequencies avoided the phenomenon of bone sclerosis as confirmed by significantly lower SBT values in treated animals in comparison to the control group","[64, 576, 561, 878]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"nant with a reduction in SBT, whereas in the later +ones, bone formation took over.34 However, discordant +results have been reported when histomorphometry +was applied to SBT and epiphyseal trabecular b","[582, 415, 1081, 737]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,"After assessing the percentage variations of each considered histomorphometric parameter, an interesting comparison between this study with the authors two previous studies $ ^{25,26} $ was possible a","[582, 737, 1080, 879]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,figure_title,"Table 5. Histomorphometric Results of Epiphyseal Femoral and Tibial Bone for Sham-Treated and PEMF-Treated at 37 and 75 Hz Groups (Mean ± SD, n = 10)","[65, 941, 1080, 988]",table_caption,0.9,"[""table prefix matched: Table 5. Histomorphometric Results of Epiphyseal Femoral and""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,10,table,"
ParametersGroupsMedial Tibial Plateau $ ^{*,,\#} $Medial Femoral Condyle $ ^{*,,\#} $Lateral Tibial Plateau $ ^{*,} $Lateral Femoral Condyle","[62, 995, 1072, 1324]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,11,vision_footnote,Multiple comparison Bonferroni's test. BV/TV: *Medial tibial plateau and medial femoral condyle versus lateral tibial plateau and lateral femoral condyle (p = 0.001): each medial compartment versus al,"[65, 1328, 1079, 1476]",footnote,0.7,"[""vision_footnote label: Multiple comparison Bonferroni's test. BV/TV: *Medial tibial""]",footnote,0.7,body_zone,body_like,none,True,True +6,12,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[67, 1503, 405, 1523]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,header,PEMF FREQUENCY RESPONSE IN OA,"[739, 67, 1056, 89]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,683,"[1083, 68, 1119, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,"21, $ ^{26} $ and 24 months old. This analysis indicated that in the later OA stage of the present work, PEMFs were still effective at counteracting the progression of OA, but with greater positive ef","[105, 115, 602, 508]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,"The spontaneous OA model used has been already well characterized and shown to be a reliable model for the study of knee OA. Degenerative changes, similar to humans, of either articular cartilage or s","[105, 507, 602, 805]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"As observed in the SHAM animals of the current study, in this late OA stage (21 months old) the medial tibial plateau showed the worst values in FI and cartilage histological grading score parameters,","[106, 805, 602, 992]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"ison with the SHAM animals of the other two previous +studies25,26 (data not shown), thus confirming the +severity of OA stage. +I h li h ifi i di i","[625, 117, 1120, 187]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"In the literature, there are no specific indications about the length of exposure, duration, and how long PEMF should be applied to subjects. In an in vitro study, De Mattei et al. $ ^{18} $ observed ","[623, 187, 1122, 991]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,figure_title,A,"[146, 1028, 173, 1054]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,8,chart,,"[147, 1037, 600, 1330]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,9,figure_title,B,"[622, 1027, 647, 1053]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,10,chart,,"[623, 1057, 1078, 1329]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,11,figure_title,"Figure 2. (A) Percentage variation of Cartilage Histological Score, FI, cartilage thickness, SBT results measured in the medial tibial plateau of the PEMF-treated at 75 Hz group and Sham-treated group","[107, 1342, 1121, 1477]",figure_caption,0.92,"[""figure_title label: Figure 2. (A) Percentage variation of Cartilage Histological""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,12,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[783, 1504, 1119, 1522]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,0,number,684,"[69, 69, 105, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,VERONESI ET AL.,"[135, 68, 286, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,text,"present study, it can only be hypothesized that this frequency exerted a stronger anti-inflammatory effect thus reducing catabolic mediators and increasing anabolic cytokine concentration.","[66, 118, 558, 209]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,The second limitation is that microtomographic analyses of the subchondral bone changes were not performed but were analyzed by histomorphometry which is strongly correlated with micro-CT measurements,"[65, 210, 559, 323]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,CONCLUSIONS,"[67, 345, 225, 367]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSIONS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +8,5,text,"Although the use of different frequencies should not affect patient compliance to therapy, it was interesting to verify if a lower frequency may eventually reproduce the same biological effects of the","[65, 370, 559, 621]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"PEMFs are a local treatment and cannot be expected to treat OA in all joints. Nevertheless, OA located at specific joints, most frequently knee and hip, has a severe impact on patients' lives and requ","[66, 622, 559, 852]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,paragraph_title,ACKNOWLEDGMENTS,"[68, 873, 291, 894]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +8,8,text,"The study was funded by “Prevenzione e cura dell'osteoartite: Patogenesi e terapie alternative” project, Monte Paschi di Siena foundation and Rizzoli Orthopedic Institute (MetaLab Research foundation)","[66, 896, 558, 1024]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,paragraph_title,REFERENCES,"[69, 1049, 193, 1071]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +8,10,reference_content,"1. 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Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodi","[634, 178, 1120, 275]",reference_item,0.85,"[""reference content label: 37. Mohan G, Perilli E, Kuliwaba JS, et al. 2011. Applicatio""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,15,reference_content,"38. Lindsey CT, Narasimhan A, Adolfo JM, et al. 2004. Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee. Osteoarthritis ","[635, 278, 1118, 354]",reference_item,0.85,"[""reference content label: 38. Lindsey CT, Narasimhan A, Adolfo JM, et al. 2004. Magnet""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,16,reference_content,"39. Ding M, Danielsen CC, Hvid I. 2005. Effects of hyaluronan on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Bone 36:489–501.","[634, 357, 1119, 433]",reference_item,0.85,"[""reference content label: 39. Ding M, Danielsen CC, Hvid I. 2005. Effects of hyalurona""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,17,reference_content,"40. Ciombor DM, Aaron RK, Wang S, et al. 2003. Modification of osteoarthritis by pulsed electromagnetic field-a morphological study. Osteoarthritis cartilage 11:455–462.","[635, 437, 1120, 495]",reference_item,0.85,"[""reference content label: 40. Ciombor DM, Aaron RK, Wang S, et al. 2003. Modification ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,18,reference_content,"41. Jimenez PA, Glasson SS, Trubetskoy OV, et al. 1997. Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes. Lab Anim Sci 47:598–601.","[635, 498, 1118, 573]",reference_item,0.85,"[""reference content label: 41. Jimenez PA, Glasson SS, Trubetskoy OV, et al. 1997. Spon""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,19,reference_content,"42. Huebner JL, Otterness IG, Freund EM, et al. 1998. Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis. Arthritis Rheum 41:877–890.","[634, 576, 1119, 634]",reference_item,0.85,"[""reference content label: 42. Huebner JL, Otterness IG, Freund EM, et al. 1998. Collag""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,20,reference_content,"43. Aaron RK, Ciombor DM, Keeping H, et al. 1999. Power frequency fields promote cell differentiation coincident with an increase in transforming growth factor- $ \beta $1 expression. Bioelectromagnet","[634, 637, 1118, 713]",reference_item,0.85,"[""reference content label: 43. Aaron RK, Ciombor DM, Keeping H, et al. 1999. Power freq""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,21,reference_content,"44. Fini M, Pagani S, Giavaresi G, et al. 2013. Functional tissue engineering in articular cartilage repair: is there a role for electromagnetic biophysical stimulation? Tissue Eng Part B Rev 19:353–3","[635, 717, 1118, 793]",reference_item,0.85,"[""reference content label: 44. Fini M, Pagani S, Giavaresi G, et al. 2013. Functional t""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,22,reference_content,"45. Thomsen JS, Laib A, Koller B, et al. 2005. Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bo","[633, 796, 1119, 873]",reference_item,0.85,"[""reference content label: 45. Thomsen JS, Laib A, Koller B, et al. 2005. Stereological""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,23,footer,JOURNAL OF ORTHOPAEDIC RESEARCH MAY 2014,"[783, 1505, 1118, 1522]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/3MPHY9LD/block_trace.csv b/tests/fixtures/ocr_real_papers/3MPHY9LD/block_trace.csv new file mode 100644 index 00000000..c021461a --- /dev/null +++ b/tests/fixtures/ocr_real_papers/3MPHY9LD/block_trace.csv @@ -0,0 +1,564 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,RESEARCH ARTICLE,"[97, 53, 358, 81]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header_image,,"[1037, 2, 1191, 26]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,2,header,ADVANCED SCIENCE,"[936, 32, 1094, 87]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,www.advancedscience.com,"[887, 97, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,doc_title,Machine Learning-Enhanced Optimization for High-Throughput Precision in Cellular Droplet Bioprinting,"[96, 148, 1063, 241]",paper_title,0.8,"[""page-1 zone title_zone: Machine Learning-Enhanced Optimization for High-Throughput P""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Jaemyung Shin, Ryan Kang, Kinam Hyun, Zhangkang Li, Hitendra Kumar, Kangsoo Kim, Simon S. Park, and Keekyoung Kim*","[91, 269, 1089, 338]",authors,0.8,"[""page-1 zone author_zone: Jaemyung Shin, Ryan Kang, Kinam Hyun, Zhangkang Li, Hitendra""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,abstract,"Organoids produce through traditional manual pipetting methods face challenges such as labor-intensive procedures and batch-to-batch variability in quality. To ensure consistent organoid production, 3","[95, 400, 740, 899]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,7,paragraph_title,1. Introduction,"[98, 962, 247, 987]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,8,text,"Bioprinting has the potential to replace 2D cell cultures by more closely replicating the 3D microtissue environment. $ ^{[1,2]} $ Moreover, its versatility enables a broad spectrum of applications, s","[95, 999, 588, 1091]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,text,"transplantation, $ ^{[5]} $ pharmaceuticals and high-throughput screening, $ ^{[6]} $ and cancer research. $ ^{[7]} $ Among many types of bioprinting, pneumatic extrusion bioprinting offers significan","[763, 387, 1099, 957]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,10,text,"et al. utilized inkjet bioprinting to create droplet-shaped structures with a gelatin methacrylate (GelMA) hydrogel precursor combined with cells, analyzing cell responses to an elastic composite subs","[605, 959, 1099, 1045]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,11,text,The common challenges frequently encountered in these studies include the intricate process of achieving consistent,"[605, 1046, 1100, 1091]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,12,footnote,"J. Shin, Z. Li, K. Kim +Department of Biomedical Engineering +Schulich School of Engineering +University of Calgary +Calgary, Alberta T2N 1N4, Canada +E-mail: keekyoung.kim@ucalgary.ca","[97, 1138, 367, 1250]",footnote,0.7,"[""footnote label: J. Shin, Z. Li, K. Kim\nDepartment of Biomedical Engineering\n""]",footnote,0.7,body_zone,body_like,none,True,True +1,13,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/advs.202412831,"[97, 1295, 588, 1336]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,14,footnote,"R. Kang, K. Kim +Department of Electrical and Software Engineering +Schulich School of Engineering +University of Calgary +Calgary, Alberta T2N 1N4, Canada","[606, 1139, 954, 1234]",footnote,0.7,"[""footnote label: R. Kang, K. Kim\nDepartment of Electrical and Software Engine""]",footnote,0.7,body_zone,body_like,none,True,True +1,15,footnote,"© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and repr","[95, 1339, 588, 1413]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2025 The Author(s). Advanced Science published by Wiley-VC""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,16,footnote,"K. Hyun, S. S. Park, K. Kim +Department of Mechanical and Manufacturing Engineering +Schulich School of Engineering +University of Calgary +Calgary, Alberta T2N 1N4, Canada +H. Kumar +Department of Bioscien","[606, 1234, 1004, 1403]",footnote,0.7,"[""footnote label: K. Hyun, S. S. Park, K. Kim\nDepartment of Mechanical and Man""]",footnote,0.7,body_zone,body_like,none,True,True +1,17,footer,DOI: 10.1002/advs.202412831,"[97, 1420, 331, 1443]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,18,footer,"Adv. Sci. 2025, 12, 2412831","[98, 1487, 260, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,19,number,2412831 (1 of 20),"[394, 1484, 528, 1508]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,20,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[663, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[931, 32, 1089, 90]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +2,2,header,www.advancedscience.com,"[881, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,text,"microscale droplets of uniform size. Additionally, optimizing numerous bioprinting parameters, such as temperature, bioink properties, printing time, printing speed, nozzle size, and dispensing pressu","[89, 149, 582, 1049]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,4,text,"In this study, we developed a novel bioprinter designed to address the challenges of high-throughput and precise 3D cellular droplet bioprinting. The system is equipped with a large-scale data collect","[89, 1048, 582, 1268]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"The combination of ML with advanced bioprinting technology can potentially accelerate research in tissue engineering and precision medicine.[23] ML refers to computer programs that based on big data, ","[89, 1267, 582, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"ing the inkjet-based bioprinting process.[25] However, the au- +thors noted that additional experiments are required to collect +a broader range of parameters for further improvement. In the +development","[599, 149, 1093, 567]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"To provide users with enhanced controllability and printability, we established a high-throughput bioprinting platform incorporating data-driven traditional ML and DL for bioprinting the array of cell","[599, 565, 1093, 1028]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,2. Results,"[602, 1053, 704, 1079]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,paragraph_title,2.1. Mechanical and Physiochemical Properties Investigation of GelMA-Alginate Bioinks,"[600, 1091, 1081, 1137]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Mechanical and Physiochemical Properties Investigation ""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +2,10,text,Achieving a successful bioprinted scaffold depends on biomaterials with optimized rheological properties. Rheological assessments were conducted on various biomaterial combinations to evaluate their s,"[598, 1157, 1092, 1312]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,text,"Figure 2a illustrates the rheological behavior of various GelMA-alginate compositions during the photocrosslinking process. The bioinks used in this study are designated as 5G, 5G0.5A, 5G1A, and 5G2A,","[599, 1311, 1093, 1445]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 2a illustrates the rheological behavior of various Ge""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +2,12,footer,"Adv. Sci. 2025, 12, 2412831","[93, 1487, 254, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,13,footer,2412831 (2 of 20),"[389, 1484, 523, 1508]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,14,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,15,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://onlinel","[1153, 30, 1172, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[97, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[932, 32, 1094, 105]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,2,header,www.advancedscience.com,"[887, 97, 1096, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,3,image,,"[235, 152, 962, 421]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,image,,"[245, 458, 870, 716]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,5,figure_title,"Figure 1. Overview of machine learning types and neural network structures. a) Machine learning encompasses various approaches, including supervised learning (e.g., regression and classification), uns","[96, 723, 1100, 782]",figure_caption,0.92,"[""figure_title label: Figure 1. Overview of machine learning types and neural netw""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,6,text,GelMA. These notations are used consistently throughout the manuscript to describe the GelMA-alginate formulations.,"[95, 828, 587, 872]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"The 5% (w/v) GelMA (5G) formulation exhibited the highest storage modulus upon light exposure, indicating superior elastic properties and robust network formation. This suggests that the 5G precursor ","[95, 872, 588, 1268]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"As the alginate concentration increased, the loss modulus appeared to slightly increase (Figure 2b). This trend aligns with the decrease in storage modulus, as the alginate is thought to interfere wit","[95, 1267, 588, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"with the crosslinking process, resulting in a more gradual transi- +tion from viscous to elastic behavior. The initial loss modulus (be- +fore initiating the light exposure) tends to be higher for sampl","[604, 828, 1098, 1070]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"As shown in Figure 2c, the storage modulus remains relatively constant across a range of angular frequencies, indicating that the material has formed a stable and elastic network. All materials used i","[604, 1071, 1098, 1377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,text,"Additionally, the static viscosity of the material, a critical bio-printing parameter, was investigated. During this measurement, a fluid typically exhibits a viscosity plateau at lower shear rates.","[605, 1377, 1098, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,footer,"Adv. Sci. 2025, 12, 2412831","[98, 1487, 260, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,13,number,2412831 (3 of 20),"[394, 1484, 528, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,14,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[663, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,15,aside_text,"21983844, 2025, 20. Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1153, 30, 1172, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +4,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 45, 340, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header,"ADVANCED SCIENCE +Open Access +advancedscience.com","[925, 31, 1090, 113]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,header,www.advancedscience.com,"[881, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,3,figure_title,a,"[101, 155, 122, 176]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,4,chart,,"[97, 165, 420, 414]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,5,figure_title,b,"[405, 151, 427, 177]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,6,chart,,"[427, 165, 736, 418]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,7,figure_title,C,"[715, 155, 735, 177]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,8,chart,,"[737, 183, 1076, 419]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,9,figure_title,e,"[326, 428, 346, 450]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,10,figure_title,d,"[98, 424, 120, 451]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,11,chart,,"[99, 472, 328, 716]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,12,figure_title,f,"[547, 424, 563, 450]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,13,figure_title,Composition of material,"[142, 707, 339, 729]",figure_caption_candidate,0.85,"[""figure_title label: Composition of material""]",figure_caption,0.85,body_zone,unknown_like,none,False,False +4,14,image,,"[347, 457, 534, 631]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,15,figure_title,g,"[777, 428, 800, 455]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,16,chart,,"[557, 454, 777, 736]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,17,chart,,"[785, 471, 1084, 734]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,18,figure_title,"Figure 2. Rheological, mechanical, and physical characterization of GelMA-alginate hydrogels. a) Storage modulus measured at the initiation of light exposure after 60 sec. b) Loss modulus measured at ","[91, 747, 1089, 845]",figure_caption,0.92,"[""figure_title label: Figure 2. Rheological, mechanical, and physical characteriza""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,19,text,"and then displays shear thinning as the shear rate increases, forming a flow curve. Alginate, a high molecular weight polysaccharide, increases the average molecular weight of the entire hydrogel prec","[89, 872, 582, 1113]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,20,text,"To evaluate the transparency, the logo remained visible in the 5G and 5G0.5A samples (Figure 2e). Conversely, the 5G1A sample showed reduced visibility of the logo, while the 5G2A sample exhibited com","[90, 1113, 581, 1266]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,21,text,"As the alginate concentration increases, the initial mechanical strength of the hydrogel is enhanced. However, excessive alginate concentrations may interfere with the photocrosslinking of GelMA. Figu","[89, 1267, 582, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,22,text,"Due to alginate’s high hydrophilicity, its incorporation into +GelMA enhances the hydrogel network’s porosity, generally lead- +ing to an increased swelling ratio.[35,36] As shown in Figure 2g, +the swel","[599, 872, 1092, 982]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,23,paragraph_title,2.2. Development and Validation of the Developed Bioprinting Platform,"[600, 1027, 1070, 1071]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Development and Validation of the Developed Bioprinting""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,24,text,A conversion of a commercially available 3D printer into a bioprinter is detailed in Shin et al. $ ^{[12]} $. This modified system was based on a low-cost 3-axis fused deposition modeling printer (End,"[599, 1091, 1092, 1356]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,25,text,"To accommodate the data-intensive nature of ML training, a movable printing stage along with additional modifications was incorporated into the original 3D bioprinting platform (Figure 3a). The G-code","[600, 1356, 1093, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,26,footer,"Adv. Sci. 2025, 12, 2412831","[93, 1487, 254, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,27,footer,2412831 (4 of 20),"[389, 1484, 523, 1508]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,28,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,29,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, China, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://","[1154, 29, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header_image,,"[930, 31, 1096, 115]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,2,figure_title,a,"[108, 152, 129, 174]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,3,image,,"[153, 154, 1043, 655]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,4,figure_title,b,"[109, 673, 130, 698]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,5,image,,"[100, 680, 559, 943]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,figure_title,C,"[575, 678, 597, 699]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,7,figure_title,d,"[820, 674, 843, 700]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,8,chart,,"[568, 717, 821, 986]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,9,chart,,"[836, 705, 1092, 934]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,10,figure_title,e,"[108, 997, 129, 1019]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,11,chart,,"[137, 1016, 502, 1233]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,12,figure_title,f,"[518, 992, 535, 1019]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,13,chart,,"[531, 1015, 897, 1234]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,figure_title,Figure 3. a) Modified and developed 3D bioprinting setup. b) Impact of in-syringe bioink homogenization on cell distribution and viability in bioprinted constructs. c) Comparison of bioprinted cell nu,"[95, 1243, 1099, 1341]",figure_caption,0.92,"[""figure_title label: Figure 3. a) Modified and developed 3D bioprinting setup. b)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,15,footer,"Adv. Sci. 2025, 12, 2412831","[98, 1487, 260, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,16,number,2412831 (5 of 20),"[395, 1484, 528, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,17,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,18,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1153, 28, 1172, 1531]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 45, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header_image,,"[931, 31, 1089, 90]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +6,2,header,www.advancedscience.com,"[882, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,figure_title,"Table 1. Bioprinting parameters used to achieve the desired droplet volume include biomaterial viscosity, nozzle size, printing time, printing pressure, and cell concentration.","[90, 150, 1089, 191]",table_caption,0.9,"[""table prefix matched: Table 1. Bioprinting parameters used to achieve the desired ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,4,table,"
Independent variablesDependent variables
Viscosity (mPa·s)Nozzle size (I.D. $ ^{a} $) mm)Printing time (s)Printing press","[90, 204, 1089, 343]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,5,vision_footnote, $ ^{a)} $ I.D.: inner diameter,"[93, 346, 223, 368]",footnote,0.7,"[""vision_footnote label: $ ^{a)} $ I.D.: inner diameter""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +6,6,text,"stepper motor, shifting the printing linear stage to the right after each droplet deposition, thereby facilitating the acquisition of new cell-laden droplet image data (Movie S1, Supporting Informatio","[89, 399, 582, 926]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"In Figure 3b, the dispensed bioink was immediately crosslinked and imaged under a microscope at three time points: at the start of printing (T0), 30 min later (T30), and 60 min later (T60) (Movie S5, ","[88, 926, 583, 1232]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,The printed green fluorescent protein (GFP)-tagged 3T3 cell-laden droplets were produced in various sizes (up to 50 μL) on a 96-well plate. The fluorescence signal was measured at an absorbance of 492,"[88, 1232, 582, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"a higher number of cells (Figure 3d). This indicates that the de- +veloped bioprinting system not only produces uniform and sta- +ble droplets but also automates the data collection process, en- +abling ","[599, 399, 1093, 532]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"Additionally, this study focused on identifying and quantifying the relative importance of bioprinting parameters in determining the final volume of bioprinted droplets (Table 1). Using a systematic a","[598, 530, 1094, 1081]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,paragraph_title,2.3. Image Processing and Droplet Volume Calculation,"[600, 1102, 1013, 1125]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Image Processing and Droplet Volume Calculation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,12,text,"To achieve uniform droplet volume during bioprinting and maintain consistent printing conditions, the substrate of the glass slide was treated with a hydrophobic silane coating (Figure 4a). This treat","[598, 1145, 1093, 1434]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,13,footer,"Adv. Sci. 2025, 12, 2412831","[93, 1487, 254, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,14,footer,2412831 (6 of 20),"[389, 1484, 523, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,15,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,16,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1153, 29, 1172, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +7,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 346, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header_image,,"[890, 31, 1096, 117]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +7,2,figure_title,a,"[109, 154, 130, 176]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,3,image,,"[102, 179, 432, 387]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,4,figure_title,b,"[430, 150, 452, 176]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,5,figure_title,C,"[664, 154, 685, 176]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,6,image,,"[442, 179, 753, 418]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,7,image,,"[763, 168, 1088, 412]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,8,figure_title,d,"[109, 417, 131, 443]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,9,vision_footnote,Raw images,"[133, 446, 258, 474]",footnote,0.7,"[""vision_footnote label: Raw images""]",footnote,0.7,body_zone,unknown_like,short_fragment,True,True +7,10,vision_footnote,Image processing,"[516, 446, 698, 476]",footnote,0.7,"[""vision_footnote label: Image processing""]",footnote,0.7,body_zone,unknown_like,short_fragment,True,True +7,11,vision_footnote,Contact Angle,"[922, 445, 1066, 475]",footnote,0.7,"[""vision_footnote label: Contact Angle""]",footnote,0.7,body_zone,unknown_like,short_fragment,True,True +7,12,image,,"[112, 511, 1083, 671]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,e,"[114, 682, 133, 705]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,14,image,,"[153, 721, 349, 908]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,15,figure_title,f,"[604, 682, 620, 709]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,16,image,,"[364, 713, 563, 909]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,17,chart,,"[630, 684, 955, 928]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,18,figure_title,g,"[106, 940, 128, 967]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,19,image,,"[120, 941, 978, 1256]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,20,figure_title,Figure 4. a) High-throughput bioprinting multiple cellular droplets during a single bioprinting run on a silane-coated glass slide. b) Demonstration of consistency in bioprinted GFP-tagged 3T3 fibrobl,"[96, 1264, 1099, 1401]",figure_caption,0.92,"[""figure_title label: Figure 4. a) High-throughput bioprinting multiple cellular d""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,21,footer,"Adv. Sci. 2025, 12, 2412831","[98, 1487, 260, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,22,number,2412831 (7 of 20),"[395, 1484, 528, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,23,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,24,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://onlinel","[1153, 29, 1172, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +8,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header_image,,"[931, 31, 1088, 90]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +8,2,header,www.advancedscience.com,"[882, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"A micro ruler was placed at the droplet dispensing location to precisely measure the actual length of the droplet at the dispensing point, yielding a value of 10 mm. The corresponding pixel count for ","[89, 149, 582, 303]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"To outline the development of our custom droplet size calculation software, the image processing pipeline incorporates a series of techniques to enhance efficiency and accuracy. Precise edge detection","[89, 303, 582, 676]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"In Figure 4e, the manual droplet volume measurement was performed by analyzing the raw image in Figure 4d using ImageJ, where five points were manually placed along the droplet boundary and the volume","[89, 675, 582, 1140]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,display_formula, $$ \mathrm{V}=\frac{\pi D^{3}}{24}\left(\frac{2-3\cos\theta+\cos^{3}\theta}{\sin^{3}\theta}\right) $$ ,"[90, 1156, 340, 1205]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,7,formula_number,(1),"[557, 1170, 578, 1192]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,8,text,"where r is the radius of the droplet base (in mm), h is the height of the droplet (in mm), V is the calculated droplet volume (in $ \mu $L), and $ \theta $ is the contact angle between the droplet a","[90, 1223, 581, 1312]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,text,"Both measurements for this analysis were obtained from 10 randomly selected droplets from each size group (small, medium, and large), resulting in a total of 30 images. These images were chosen to val","[90, 1311, 582, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,text,"sure that the subset effectively captured the range of droplet sizes +observed in the full dataset. The analysis encompassed droplets +of various sizes: small droplets with a mean volume of 3.54 μL, +medi","[599, 150, 1092, 346]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,11,text,"By combining these processed images, we achieved reliable and consistent volume measurements across all samples, demonstrating the robustness of the proposed approach in capturing the fine details nec","[599, 347, 1093, 721]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,paragraph_title,2.4. Optimization of the Hyperparameters,"[601, 764, 920, 787]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Optimization of the Hyperparameters""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,13,text,"Optimal hyperparameter tuning is essential for maximizing the performance of traditional ML models. By leveraging various optimization methods, such as grid search, random search, Bayesian optimizatio","[600, 806, 1092, 960]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,14,text,"To evaluate the performance of the algorithms in predicting printing parameters, our study was structured into two distinct phases: Phase 1, focuses on hyperparameter optimization, and Phase 2, compar","[600, 961, 1093, 1224]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,text,An optimization process was conducted to determine the optimal hyperparameters for each algorithm. This process involved 10-fold cross-validation to identify the hyperparameters that yielded the best ,"[599, 1224, 1093, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,16,footer,"Adv. Sci. 2025, 12, 2412831","[93, 1487, 254, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,17,footer,2412831 (8 of 20),"[389, 1484, 523, 1508]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,18,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,19,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://onlinel","[1153, 29, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 346, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header_image,,"[931, 31, 1096, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +9,2,figure_title,a,"[116, 156, 137, 179]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,3,chart,,"[103, 189, 371, 424]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,4,figure_title,b,"[408, 152, 430, 180]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,5,chart,,"[394, 194, 660, 421]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,6,figure_title,C,"[684, 156, 704, 180]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,7,chart,,"[679, 190, 952, 421]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,8,figure_title,d,"[117, 433, 140, 460]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,chart,,"[109, 457, 365, 691]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,10,figure_title,e,"[414, 437, 435, 459]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,11,chart,,"[383, 461, 659, 694]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,12,figure_title,f,"[122, 687, 140, 715]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,13,vision_footnote,"- Train MSE +-☑ Validation MSE +-☑ Train MAE +-☑ Validation MAE +-☑ Train RMSE +-☑ Validation RMSE +-☑ Train R-squared +-☑ Validation R-squared","[673, 469, 875, 660]",footnote,0.7,"[""vision_footnote label: - Train MSE\n-\u2611 Validation MSE\n-\u2611 Train MAE\n-\u2611 Validation MAE""]",footnote,0.7,body_zone,unknown_like,none,True,True +9,14,figure_title,g,"[411, 692, 434, 720]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,15,chart,,"[118, 716, 391, 954]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,16,figure_title,h,"[681, 687, 705, 715]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,17,chart,,"[404, 717, 662, 930]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,18,figure_title,i,"[132, 956, 147, 982]",figure_inner_text,0.9,"[""panel label / figure inner text: i""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,19,chart,,"[686, 727, 979, 955]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,20,figure_title,j,"[415, 956, 432, 988]",figure_inner_text,0.9,"[""panel label / figure inner text: j""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,21,chart,,"[104, 997, 422, 1228]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,22,chart,,"[412, 994, 702, 1225]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,23,figure_title,k,"[690, 956, 710, 983]",figure_inner_text,0.9,"[""panel label / figure inner text: k""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,24,chart,,"[697, 964, 1091, 1226]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,25,figure_title,Figure 5. a) Optimization process for identifying the optimized hyperparameters for a decision tree. b) Optimization process for identifying the optimized hyperparameters for a random forest. c) Optim,"[97, 1253, 1098, 1407]",figure_caption,0.92,"[""figure_title label: Figure 5. a) Optimization process for identifying the optimi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,26,footer,"Adv. Sci. 2025, 12, 2412831","[98, 1487, 260, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,27,number,2412831 (9 of 20),"[395, 1484, 528, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,28,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,29,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by Cochrane, China, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://","[1154, 29, 1171, 1532]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +10,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 45, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header_image,,"[930, 33, 1089, 93]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +10,2,header,www.advancedscience.com,"[881, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,3,figure_title,Table 2. Computation times of three traditional machine learning algorithms and two deep learning algorithms using the dataset with optimized hyperparameter. Training and validation times are presente,"[91, 149, 581, 223]",table_caption,0.9,"[""table prefix matched: Table 2. Computation times of three traditional machine lear""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,4,table,,"[91, 240, 578, 395]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +10,5,text,"7, while the random forest (RF) demonstrated superior performance with 10 estimators (Figure 5b). Given the multitude of hyperparameters in RF, a systematic approach employing GridSearchCV, an automat","[89, 434, 582, 766]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,paragraph_title,2.5. Computation Time for Hyperparameter Optimization,"[90, 807, 523, 830]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Computation Time for Hyperparameter Optimization""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,7,text,Hyperparameter optimization often involves exploring numerous combinations of hyperparameters. The time required to evaluate each combination directly impacts the overall optimization process. Typical,"[89, 850, 582, 1180]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,text,"The complexity of the model, such as the depth of a neural network or the number of trees in an RF, directly impacts the duration of the training. More complex models require additional time to conver","[89, 1180, 583, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,9,text,"management can help balance the time requirements of these +phases, ultimately enabling more effective and timely model de- +velopment.","[600, 148, 1093, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,paragraph_title,2.6. Comparative Evaluation of Machine Learning Algorithms for Droplet Volume Prediction,"[601, 255, 1087, 301]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Comparative Evaluation of Machine Learning Algorithms f""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,11,text,The hyperparameters identified as optimal during the initial optimization phase were applied to each algorithm. Each model was then subjected to a rigorous training and evaluation process involving 10,"[599, 321, 1093, 716]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,12,text,"Second, mean squared error (MSE) is calculated by averaging the squared differences between predicted and actual values. Lower MSE values indicate a closer alignment between model predictions and actu","[598, 715, 1093, 1067]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,13,text,"Third, RMSE mitigates the distortion caused by squaring the errors in MSE by taking the square root, making it more interpretable. Unlike MSE, RMSE provides a more intuitive measure of error in the sa","[599, 1066, 1093, 1157]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,14,figure_title,Table 3. Performance evaluation of three traditional machine learning algorithms and two deep learning algorithms.,"[600, 1186, 1091, 1227]",table_caption,0.9,"[""table prefix matched: Table 3. Performance evaluation of three traditional machine""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,15,table,
AlgorithmsTraining time (ms)Validation time (ms)
Decision tree0.9982821.591182
Random forest18.855333
AlgorithmsMean Absolute Error (MAE)Root Mean Square Error (RMSE)R-Squared
Decision tree0.329 $ \pm $ 0.0170.582 $ \pm $ 0,"[602, 1242, 1088, 1434]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +10,16,footer,"Adv. Sci. 2025, 12, 2412831","[93, 1487, 254, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,17,footer,2412831 (10 of 20),"[384, 1483, 527, 1508]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,18,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[657, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,19,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1154, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +11,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 346, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header_image,,"[931, 32, 1096, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +11,2,figure_title,a,"[104, 155, 124, 177]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,3,chart,,"[108, 166, 362, 423]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,4,figure_title,b,"[369, 152, 391, 176]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,5,chart,,"[368, 157, 603, 423]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,6,figure_title,C,"[611, 155, 631, 177]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,7,chart,,"[616, 165, 834, 427]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,8,chart,,"[848, 148, 1055, 426]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,9,figure_title,e,"[103, 430, 122, 451]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,10,chart,,"[109, 453, 415, 672]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,11,figure_title,f,"[426, 424, 442, 451]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,12,figure_title,g,"[749, 431, 769, 456]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,13,chart,,"[436, 438, 744, 679]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,14,figure_title,h,"[101, 669, 123, 697]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,15,chart,,"[783, 444, 1083, 681]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,16,chart,,"[114, 671, 424, 920]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,17,chart,,"[431, 679, 748, 923]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,18,chart,,"[774, 681, 1082, 922]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,19,figure_title,k,"[107, 934, 127, 960]",figure_inner_text,0.9,"[""panel label / figure inner text: k""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,20,image,,"[115, 937, 1090, 1173]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,21,figure_title,"Figure 6. Performance evaluation of traditional machine learning and deep learning models. a) Mean absolute error across models (n.s.: not significant, $ p < 0.0001 $). b) Mean squared error comparis","[95, 1181, 1099, 1316]",figure_caption,0.92,"[""figure_title label: Figure 6. Performance evaluation of traditional machine lear""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,22,footer,"Adv. Sci. 2025, 12, 2412831","[98, 1487, 260, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,23,number,2412831 (11 of 20),"[390, 1484, 533, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,24,footer,© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH,"[664, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,25,aside_text,"21983844, 2025, 20, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202412831 by CochraneChina, Wiley Online Library on [06/01/2026]. See the Terms and Conditions (https://on","[1153, 29, 1172, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +12,0,header_image,,"[92, 45, 339, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +12,1,header_image,,"[930, 34, 1089, 92]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +12,2,header,www.advancedscience.com,"[881, 97, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,3,figure_title,Table 4. Computation times of three traditional machine learning algorithms and two deep learning algorithms were measured using the dataset to evaluate their performance.,"[90, 149, 581, 206]",table_caption,0.9,"[""table prefix matched: Table 4. Computation times of three traditional machine lear""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +12,4,table,
AlgorithmsTraining time (ms)Testing time (ms)
Decision tree0.005 $ \pm $ 0.0020.005 $ \pm $ 0.001
Random forest
Activity levelFrequency (N = 993)Percentage
National team566
Competitive athlete16016
Knee pathologyN_{o}N_{c}N_{c} / $ \pm $ ,
ACL rupture89160.18
Old ACL injury63","[87, 542, 577, 771]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +5,9,vision_footnote," $ ^{a} $N $ _{o} $, number of patients with the different knee pathology in this material; N $ _{C} $, number of patients with current diagnosis with associated localized full-thickness cartilage les","[87, 785, 579, 848]",footnote,0.7,"[""vision_footnote label: $ ^{a} $N $ _{o} $, number of patients with the different kn""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,affiliation_marker,True,True +5,10,text,"osteochondritis dissecans lesions has demonstrated that failed surgical treatment will result in degenerative changes and problems, although initial results were quite promising. $ ^{3} $ Whether this","[85, 884, 580, 1061]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,11,paragraph_title,CONCLUSION,"[88, 1095, 227, 1118]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSION""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True +5,12,text,"This study shows that 6% of the patients admitted for arthroscopic procedures have a cartilage injury of ICRS grade 3 or 4 injury and size more than 2 cm². In total, about 11% of all knee arthroscopie","[85, 1137, 581, 1271]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +5,13,text,"ber of patients that will benefit from a cartilage repair pro- +cedure are so far unknown.","[622, 161, 1116, 205]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,14,paragraph_title,REFERENCES,"[626, 240, 755, 261]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +5,15,reference_content,"1. The cartilage standard evaluation form/knee. ICRS Newsletter, spring 1998.","[632, 279, 1116, 316]",reference_item,0.85,"[""reference content label: 1. The cartilage standard evaluation form/knee. ICRS Newslet""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,16,reference_content,"2. Alfredson H, Thorsen K, Lorentzon R: Treatment of tear of the anterior cruciate ligament combined with localised deep cartilage defects in the knee with ligament reconstruction and autologous perio","[633, 319, 1116, 392]",reference_item,0.85,"[""reference content label: 2. Alfredson H, Thorsen K, Lorentzon R: Treatment of tear of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,17,reference_content,"3. Angermann P, Riegels-Nielsen P, Pedersen H: Osteochondritis dissecans of the femoral condyle treated with periosteal transplantation: Poor outcome in 14 patients followed for 6–9 years. Acta Orthop","[633, 395, 1116, 469]",reference_item,0.85,"[""reference content label: 3. Angermann P, Riegels-Nielsen P, Pedersen H: Osteochondrit""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,18,reference_content,"4. Brittberg M, Lindahl A, Nilsson A, et al: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331: 889–895, 1994","[633, 471, 1115, 525]",reference_item,0.85,"[""reference content label: 4. Brittberg M, Lindahl A, Nilsson A, et al: Treatment of de""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,19,reference_content,"5. Curl WW, Krome J, Gordon ES, et al: Cartilage injuries: A review of 31,516 knee arthroscopies. Arthroscopy 13: 456–460, 1997","[633, 528, 1116, 564]",reference_item,0.85,"[""reference content label: 5. Curl WW, Krome J, Gordon ES, et al: Cartilage injuries: A""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,20,reference_content,"6. Hangody L, Kish G, Karpati Z, et al: Mosaicplasty for the treatment of articular cartilage defects: Application in clinical practice. Orthopedics 21: 751–756, 1998","[634, 566, 1116, 620]",reference_item,0.85,"[""reference content label: 6. Hangody L, Kish G, Karpati Z, et al: Mosaicplasty for the""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,21,reference_content,"7. Hjelle K, Austgulen O, Muri R, et al: Full thickness chondral defects: A prospective study of 1000 knee arthroscopies. Presented at International Cartilage Repair Society conference, Gothenburg, 20","[633, 623, 1116, 679]",reference_item,0.85,"[""reference content label: 7. Hjelle K, Austgulen O, Muri R, et al: Full thickness chon""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,22,reference_content,"8. Lewandrowski KU, Muller J, Schollmeier G: Concomitant meniscal and articular cartilage lesions in the femorotibial joint. Am J Sports Med 25: 486–494, 1997","[634, 680, 1116, 734]",reference_item,0.85,"[""reference content label: 8. Lewandrowski KU, Muller J, Schollmeier G: Concomitant men""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,23,reference_content,"9. Lorentzon R, Alfredson H, Hildingsson C: Treatment of deep cartilage defects of the patella with periosteal transplantation. Knee Surg Sports Traumatol Arthrosc 6: 202–208, 1998","[633, 737, 1116, 791]",reference_item,0.85,"[""reference content label: 9. Lorentzon R, Alfredson H, Hildingsson C: Treatment of dee""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,24,reference_content,"10. Mandelbaum BR, Browne JE, Fu F, et al: Articular cartilage lesions of the knee. Am J Sports Med 26: 853–861, 1998","[629, 794, 1116, 830]",reference_item,0.85,"[""reference content label: 10. Mandelbaum BR, Browne JE, Fu F, et al: Articular cartila""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,25,reference_content,"11. Messner K, Gillquist J: Cartilage repair: A critical review. Acta Orthop Scand 67: 523–529, 1996","[629, 833, 1115, 867]",reference_item,0.85,"[""reference content label: 11. Messner K, Gillquist J: Cartilage repair: A critical rev""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,26,reference_content,"12. Minas T, Peterson L: Advanced techniques in autologous chondrocyte transplantation. Clin Sports Med 18: 13–44, v–vi, 1999","[629, 871, 1115, 907]",reference_item,0.85,"[""reference content label: 12. Minas T, Peterson L: Advanced techniques in autologous c""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,27,reference_content,"13. Mont MA, Jones LC, Vogelstein BN, et al: Evidence of inappropriate application of autologous cartilage transplantation therapy in an uncontrolled environment. Am J Sports Med 27: 617–620, 1999","[629, 908, 1115, 963]",reference_item,0.85,"[""reference content label: 13. Mont MA, Jones LC, Vogelstein BN, et al: Evidence of ina""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,28,reference_content,"14. Murrell GA, Maddali S, Horovitz L, et al: The effects of time course after anterior cruciate ligament injury in correlation with meniscal and cartilage loss. Am J Sports Med 29: 9–14, 2001","[629, 965, 1115, 1019]",reference_item,0.85,"[""reference content label: 14. Murrell GA, Maddali S, Horovitz L, et al: The effects of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,29,reference_content,"15. Peterson L, Minas T, Brittberg M, et al: Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop May (374): 212–234, 2000","[629, 1023, 1116, 1076]",reference_item,0.85,"[""reference content label: 15. Peterson L, Minas T, Brittberg M, et al: Two- to 9-year ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,30,reference_content,"16. Steadman JR, Rodkey WG, Singleton SB, et al: Microfracture technique for full-thickness chondral defects: Technique and clinical results. Operative Techniques in Orthopaedics 7: 300–304, 1997","[629, 1079, 1116, 1134]",reference_item,0.85,"[""reference content label: 16. Steadman JR, Rodkey WG, Singleton SB, et al: Microfractu""]",reference_item,0.85,reference_zone,reference_like,heading_numbered,True,True +5,31,reference_content,"17. Stone KR, Walgenbach A: Surgical technique for articular cartilage transplantation to full thickness cartilage defects in the knee joint. Operative Techniques in Orthopaedics 7: 305–311, 1997","[628, 1136, 1115, 1191]",reference_item,0.85,"[""reference content label: 17. Stone KR, Walgenbach A: Surgical technique for articular""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,32,reference_content,"18. Zamber RW, Teitz CC, McGuire DA, et al: Articular cartilage lesions of the knee. Arthroscopy 5: 258–268, 1989","[628, 1193, 1116, 1229]",reference_item,0.85,"[""reference content label: 18. Zamber RW, Teitz CC, McGuire DA, et al: Articular cartil""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +5,33,reference_content,"19. Årøen A, Jones DG, Fu HF: Arthroscopic diagnosis and treatment of cartilage injuries. Sports Medicine and Arthroscopy Review 6: 31–40, 1998","[630, 1232, 1117, 1284]",reference_item,0.85,"[""reference content label: 19. \u00c5r\u00f8en A, Jones DG, Fu HF: Arthroscopic diagnosis and tre""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/tests/fixtures/ocr_real_papers/4AG67PBH/block_trace.csv b/tests/fixtures/ocr_real_papers/4AG67PBH/block_trace.csv new file mode 100644 index 00000000..8fa41ece --- /dev/null +++ b/tests/fixtures/ocr_real_papers/4AG67PBH/block_trace.csv @@ -0,0 +1,700 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,REVIEW,"[99, 42, 210, 72]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header,small science,"[1014, 14, 1099, 81]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,2,header,www.small-science-journal.com,"[883, 86, 1098, 107]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,3,doc_title,Gathering Evidence to Leverage Musculoskeletal Magnetic Stimulation Towards Clinical Applicability,"[96, 135, 1080, 225]",paper_title,0.8,"[""page-1 zone title_zone: Gathering Evidence to Leverage Musculoskeletal Magnetic Stim""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"José G. S. Figueiredo, Bárbara M. de Sousa, Marco P. Soares dos Santos,* and Sandra I. Vieira*","[91, 254, 947, 320]",authors,0.8,"[""page-1 zone author_zone: Jos\u00e9 G. S. Figueiredo, B\u00e1rbara M. de Sousa, Marco P. Soares ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,abstract,"Musculoskeletal disorders are among the main causes of disease-associated disability. Moreover, the incidence and prevalence of osteoporosis and osteoarthritis, as well as the risk of bone fractures a","[97, 386, 735, 883]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,6,paragraph_title,1. Introduction,"[98, 951, 247, 976]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,7,text,"The 2019 Global Burden of Disease placed musculoskeletal disorders among the 10 top drivers of increasing burden, given its increasing impact on disability-adjusted life-years (DALYs) from 1990 to 201","[95, 992, 589, 1130]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,"needs of individuals affected by musculoskeletal conditions endangering functional health.[3,4] Surgery is indicated for severe musculoskeletal disorders that cause substantial pain and disability, an","[765, 365, 1099, 770]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,text,"Active bone healing, key for long-term successful therapies, may be achieved by stimulating bone tissue remodeling via biochemical, mechanical, or electromagnetic stimuli. $ ^{[9]} $ The benefits of e","[765, 770, 1098, 948]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,10,text,"functions, pharmaceuticals' delivery (iontophoresis), among others. $ ^{[10-13]} $ Bone and other musculoskeletal tissues may also benefit from these, given their responsiveness to extracorporeal elec","[604, 949, 1099, 1130]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,footnote,"J. G. S. Figueiredo, B. M. de Sousa, S. I. Vieira +Department of Medical Sciences +Institute of Biomedicine (iBiMED) +University of Aveiro +3810-193 Aveiro, Portugal +E-mail: sivieira@ua.pt","[95, 1165, 424, 1276]",footnote,0.7,"[""footnote label: J. G. S. Figueiredo, B. M. de Sousa, S. I. Vieira \nDepartme""]",footnote,0.7,body_zone,body_like,none,True,True +1,12,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smsc.202300303.,"[98, 1283, 588, 1325]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,13,footnote,"M. P. Soares dos Santos +Department of Mechanical Engineering +Centre for Mechanical Technology & Automation (TEMA) +University of Aveiro +3810-193 Aveiro, Portugal +E-mail: marco.santos@ua.pt","[607, 1165, 1006, 1276]",footnote,0.7,"[""footnote label: M. P. Soares dos Santos\nDepartment of Mechanical Engineering""]",footnote,0.7,body_zone,body_like,none,True,True +1,14,footnote,"© 2024 The Authors. Small Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduct","[96, 1332, 590, 1409]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2024 The Authors. Small Science published by Wiley-VCH Gmb""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,15,footnote,"M. P. Soares dos Santos +LASI - Intelligent Systems Associated Laboratory +Guimarães 4800-058, Portugal","[607, 1287, 942, 1343]",footnote,0.7,"[""footnote label: M. P. Soares dos Santos\nLASI - Intelligent Systems Associate""]",footnote,0.7,body_zone,body_like,none,True,True +1,16,footnote,DOI: 10.1002/smsc.202300303,"[97, 1415, 338, 1438]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: DOI: 10.1002/smsc.202300303""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,17,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,18,footer,2300303 (1 of 25),"[406, 1476, 547, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,19,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1097, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 32, 311, 106]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,small science,"[1008, 14, 1092, 81]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,header,www.small-science-journal.com,"[878, 86, 1090, 106]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,text,"electrical potentials generated in loaded bone: the piezoelectric effect (mainly on dry bone, and attributed to the crystalline micelle of collagen molecules) $ ^{[16,18,19]} $ and the streaming poten","[89, 139, 582, 402]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,Many researchers have explored the effects of electromagnetic fields on the tightly orchestrated bone remodeling process. $ ^{[30-32]} $ Several animal models have been used to test the efficacy of el,"[90, 402, 582, 843]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Three methods have been used to provide electromagnetic stimulation, which includes the delivery of electrical fields (EF) and magnetic fields (MF). Direct electric current (DC) stimulation, requiring","[90, 844, 583, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"tissues. CMF stimulation combines these coil-generated PEMF +with an overlapping static MF provided by permanent +magnets.[47] Both CC and IC methods have been proposed as +therapeutic strategies to mini","[598, 138, 1092, 427]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"We here comprehensively overview the most relevant bone healing-related outcomes induced by IC in vivo, both in animal models and human patients, aiming to identify top-performer magnetic stimulation ","[598, 425, 1093, 1007]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,2. Pre-Clinical Studies of IC Therapies 2.1. Overview of IC Pre-Clinical Designs,"[600, 1044, 973, 1107]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Pre-Clinical Studies of IC Therapies 2.1. Overview of IC ""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +2,9,footer,,"[601, 1083, 911, 1107]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,10,text,"Our search has retrieved 73 pre-clinical studies using IC stimulators to treat musculoskeletal conditions in animal models (Table S1, Supporting Information). PEMF was by far the most used IC stimulat","[599, 1127, 1092, 1372]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,text,"The pre-clinical therapeutic efficacy of IC stimulation has been tested for several musculoskeletal conditions, namely bone defects, implants' osseointegration, conditions of low bone","[599, 1371, 1093, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,footer,"Small Sci. 2024, 4, 2300303","[93, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,13,footer,2300303 (2 of 25),"[400, 1476, 541, 1499]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,14,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[680, 1479, 1091, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,15,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 23, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 31, 316, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header,small science,"[1015, 14, 1098, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +3,2,header,www.small-science-journal.com,"[884, 86, 1097, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,3,figure_title,A,"[174, 143, 194, 163]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,4,figure_title,IC stimulation methods in animal models,"[233, 158, 411, 203]",non_body_insert,0.85,"[""figure_title label: IC stimulation methods in animal models""]",figure_caption,0.85,body_zone,body_like,none,False,False +3,5,chart,,"[223, 217, 480, 424]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +3,6,figure_title,B,"[537, 142, 555, 162]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,7,figure_title,Animal models receiving IC stimulation,"[622, 151, 921, 174]",non_body_insert,0.85,"[""figure_title label: Animal models receiving IC stimulation""]",figure_caption,0.85,body_zone,legend_like,none,False,False +3,8,chart,,"[517, 198, 1020, 487]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +3,9,figure_title,C,"[174, 506, 194, 527]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,10,figure_title,Musculoskeletal conditions assessed in animal models,"[382, 514, 849, 539]",figure_caption,0.85,"[""figure_title label: Musculoskeletal conditions assessed in animal models""]",figure_caption,0.85,body_zone,legend_like,none,True,True +3,11,chart,,"[173, 547, 1003, 877]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +3,12,figure_title,D,"[174, 908, 194, 930]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,13,figure_title,E,"[621, 908, 639, 930]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,14,image,,"[179, 920, 586, 1232]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +3,15,image,,"[623, 923, 963, 1239]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +3,16,figure_title,Figure 1. General trends of IC stimulation on pre-clinical studies with animal models of musculoskeletal disorders. A) IC stimulation methods applied; B) Type of animal models used; C) Musculoskeletal,"[97, 1255, 1098, 1418]",figure_caption,0.92,"[""figure_title label: Figure 1. General trends of IC stimulation on pre-clinical s""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +3,17,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,18,number,2300303 (3 of 25),"[407, 1476, 547, 1499]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,19,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1096, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,20,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smse.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 30, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +4,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 31, 312, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header,small science,"[1008, 13, 1091, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +4,2,header,www.small-science-journal.com,"[877, 86, 1091, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,3,text,"mineral density (BMD), soft tissue healing, spine fusion, and osteoarthritis, as well as in healthy subjects. Bone defects $ ^{[59-81]} $ were the most assessed condition (in 27.4% of the studies; Fig","[89, 137, 582, 298]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,text,"in pre-clinical studies to deliver PEMF is schematically presented +in Figure 1D. Additionally, Figure 1E portrays a photograph of an +actual IC stimulation device used in a pre-clinical study here +revi","[599, 137, 1092, 226]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"The tested pulse frequencies ranged from 1 Hz $ ^{[73]} $–400 Hz, $ ^{[66]} $ with the most tested frequency being 15 Hz (in 36.5% of the tested frequencies, Figure 2A). Unless stated otherwise, all","[600, 224, 1093, 297]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,chart,,"[192, 337, 582, 844]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,7,chart,,"[615, 338, 993, 851]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,8,chart,,"[193, 857, 572, 1223]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,9,chart,,"[613, 863, 976, 1224]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,10,figure_title,"Figure 2. IC stimuli parameters applied in animal pre-clinical studies. Graphical analysis of the different IC stimulation parameters used in the 73 animal studies reviewed, plotting the number of stu","[91, 1237, 1092, 1440]",figure_caption,0.92,"[""figure_title label: Figure 2. IC stimuli parameters applied in animal pre-clinic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,11,footer,"Small Sci. 2024, 4, 2300303","[94, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,12,number,2300303 (4 of 25),"[401, 1476, 541, 1499]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,13,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[680, 1479, 1091, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,14,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.20290303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrary","[1153, 28, 1171, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 32, 317, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header,small science,"[1015, 14, 1098, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +5,2,header,www.small-science-journal.com,"[884, 86, 1097, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,3,text,"frequencies here indicated refer to pulses (that comprise sets of bursts), and not to individual bursts (see Figure S1, Supporting Information, for the distinction between pulses and bursts). MF stren","[96, 139, 588, 406]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"Regarding the biological outcomes, these may differ due to anatomical and physiological differences between the animal models. For comparative purposes, the biological outcomes were analyzed by groups","[96, 406, 588, 564]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,paragraph_title,2.2. Effects of IC Stimulation on Small-Sized Animals,"[97, 593, 505, 616]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Effects of IC Stimulation on Small-Sized Animals""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,6,text,"Rats (Rattus norvegicus) were the most used animal models to test IC stimulation in vivo (Figure 1). Rats are anatomic and physiologically well-studied, have fast growth and reproductive rates and req","[96, 637, 588, 927]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,PEMF have been applied to determine whether bone tissues from healthy rats responded well to electromagnetic stimuli. These studies were focused on major macroscopical and micro-architectural effects ,"[94, 926, 589, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,text,"Increased expression levels of femur p-PKA and p-CREB, soluble +adenyl cyclase (sAC), and serum cAMP were also observed, indi- +cating osteogenic effects through the sAC/cAMP/PKA/CREB +signaling pathway.","[605, 137, 1097, 230]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,9,paragraph_title,2.2.1. Managing Bone Defects in Small-Sized Animals Through IC Stimulation,"[607, 258, 1006, 308]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.1. Managing Bone Defects in Small-Sized Animals Through ""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,10,text,"PEMF of rather different parameters were applied to heal rat bone defects (fractures and osteotomies) and consolidate bone fusions, with promising effects such as faster osseous bridging, assessed by ","[604, 327, 1099, 883]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,"Studies using PEMF of higher pulse frequencies, from 20 to 400 Hz, have mostly reported positive impacts on bone healing (Figure 2). For example, PEMF of 50 Hz and 1.5 mT, applied to rat tibial fractu","[605, 884, 1098, 1327]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,text,"An FDA-approved PEMF device, Physio-Stim, delivering pulses at the most commonly used frequency (15 Hz pulse), of triangular or sawtooth bursts at 3.85 kHz, and 2.0 mT with a daily exposure of 3 h day","[604, 1326, 1098, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 266, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,14,footer,2300303 (5 of 25),"[407, 1476, 547, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,15,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1096, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,16,aside_text,"26884046, 2024, 5. Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smse.20290303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrary","[1153, 29, 1171, 1541]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 32, 312, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header,small science,"[1008, 13, 1092, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +6,2,header,www.small-science-journal.com,"[878, 86, 1091, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,text,"parameters over 3 and 5 weeks, and reported higher osteotomy gap filling and a 2-fold increase in hard callus formation rate and volume, and in bending strength.[69] Another study applied this stimula","[89, 139, 583, 406]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,paragraph_title,2.2.2. Studies of IC Stimulation for Soft Tissue Disorders in Small-Sized Animals,"[91, 432, 507, 480]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.2. Studies of IC Stimulation for Soft Tissue Disorders i""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,5,text,"Physio-Stim was also used for soft tissue healing in rats $ ^{[107-109]} $ and PEMF of parameters similar to the ones described above (15 Hz; ≈2 mT) led to radiographical, biomechanical, and histologi","[89, 498, 582, 813]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,paragraph_title,2.2.3. Tackling Osteoporosis in Small-Sized Animals Through IC Stimulation,"[91, 839, 562, 885]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.3. Tackling Osteoporosis in Small-Sized Animals Through ""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,7,text,"Osteoporosis, a highly relevant musculoskeletal disorder, is usually studied in animal models by mimicking osteoporotic phenotypes of low BMD, either through ovariectomy (OVX; the most used osteoporos","[90, 905, 582, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,"www.small science journal.com +better results than if the treatment was initiated 12 weeks +post-OVX, highlighting that the timing of PEMF therapy initia- +tion is important to achieve optimal effects.[1","[597, 140, 1094, 953]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"For disuse osteoporosis models, PEMF of 10 Hz and 3.82 mT, for 40 min day $ ^{-1} $ over 12 weeks, improved bone microarchitecture (increased Tb.Area and Tb.N; reduced Tb.S) and increased serum OC by ","[598, 955, 1093, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,footer,"Small Sci. 2024, 4, 2300303","[93, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,11,footer,2300303 (6 of 25),"[400, 1476, 541, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,12,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[679, 1479, 1091, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,13,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.20290303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrary","[1153, 28, 1171, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +7,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 32, 316, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header,small science,"[1014, 14, 1098, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +7,2,header,www.small-science-journal.com,"[884, 86, 1097, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,3,text,"animals), and acted on bone remodeling pathways: +42.1% serum TGF-β1 and −21.7% serum IL-6.[111] PEMF of higher frequency (50 Hz) and lower MF strength (0.6 mT), applied for 1.5 h day−1 over 4 weeks, ","[95, 139, 588, 582]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"In cases of drug-induced osteoporosis, PEMF of 7.3 Hz and 0.8 mT for 1 h day $ ^{-1} $ over 4 weeks reverted heparin-induced bone loss, increasing new bone area by 4-fold and reducing serum CTX ( $ -2","[95, 583, 588, 805]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"Finally, in senile osteoporosis models, PEMF of 8 Hz and 3.82 mT (applied for 40 min day $ ^{-1} $) partially reverted aging-related bone deterioration, after 12 weeks of stimulation. Improved BMD, bo","[95, 805, 588, 1052]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,paragraph_title,2.2.4. IC Stimulation to Improve Implant Osseointegration in Small-Sized Animals,"[97, 1080, 548, 1127]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.4. IC Stimulation to Improve Implant Osseointegration in""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,7,text,"IC stimulation was also tested on rat implants’ osseointegration. A study applying PEMF with the most common parameters (15 Hz, 1.0 mT), has compared the effectiveness of 1 vs 3 h day $ ^{-1} $ exposu","[95, 1148, 587, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"increased peri-implant and osteotomy ossification were observed +in the group stimulated for 0.5 h twice-a-day with PEMF of 50 Hz +and high MF strength (72 mT), demonstrating that this IC ther- +apy can a","[604, 138, 1098, 497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,paragraph_title,2.2.5. Handling Osteoarthritis in Small-Sized Animals with IC Stimulation,"[606, 525, 1064, 572]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2.5. Handling Osteoarthritis in Small-Sized Animals with I""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,10,text,"In two studies of a rat model mimicking temporomandibular joint osteoarthritis, PEMF of 2 mT and 15 Hz pulses (bursts of 5 kHz), applied for 2 h day $ ^{-1} $ over 3 or 6 weeks, partially reversed mic","[604, 593, 1099, 1218]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,text,"Other animals used as osteoarthritis models are guinea pigs (Cavia porcellus) of the Dunkin-Hartley breed, that spontaneously develop degenerative joint diseases around 3 months old. $ ^{[104]} $ Impr","[605, 1216, 1099, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,12,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,13,footer,2300303 (7 of 25),"[406, 1476, 547, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,14,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[686, 1479, 1097, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,15,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 22, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +8,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 32, 312, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header,small science,"[1008, 13, 1092, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +8,2,header,www.small-science-journal.com,"[878, 86, 1091, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"two pulse frequencies: 3/ and 75 Hz. Both frequencies lowered Fibrillation Index (FI) and SBT, with the 75 Hz being more beneficial to cartilage (+20.6% thickness; −18.5% cartilage FI). Nevertheless, ","[90, 137, 582, 252]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,2.3. Effects of IC Stimulation on Intermediate-Sized Animals,"[90, 285, 552, 307]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Effects of IC Stimulation on Intermediate-Sized Animals""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,5,text,"Rabbits (Oryctolagus cuniculus) are the second usual choice to study IC stimulation on bone remodeling and implants' osseointegration (Figure 1). Comparatively to smaller models, rabbits undergo more ","[90, 329, 582, 557]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,paragraph_title,2.3.1. Managing Bone Defects in Intermediate-Sized Animals Using IC Stimulation,"[91, 589, 539, 635]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3.1. Managing Bone Defects in Intermediate-Sized Animals U""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,7,text,"Various studies investigated the IC stimulation impact on callus and bone formation in rabbits' bone defects (fractures/osteotomies).[67,68,71,72,76,79] Daily distracted tibial osteotomies, exposed to","[90, 658, 583, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,paragraph_title,2.3.2. IC Stimulation Effects on Implant Osseointegration in Intermediate-Sized Animals,"[601, 140, 1044, 187]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3.2. IC Stimulation Effects on Implant Osseointegration in""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +8,9,text,Bone replacement of rabbits' hindlimbs was commonly used to test IC-induced implant osseointegration. Matsumoto et al.[82] applied 100 Hz PEMF to improve osseointegration of dental implants in rabbits,"[598, 208, 1093, 589]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,text,"Another study using PEMF of similar MF strengths but at 1/10 of the pulse frequency and with increased exposure (10 Hz, 0.2–0.4 mT, 24 h day $ ^{-1} $) for up to 4 weeks, also improved osseointegratio","[599, 588, 1093, 1350]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,11,text,"In a study comparing tibial implants, PEMF of 1.5 Hz (quasi-square pulses), 0.18 mT, applied 8 h day $ ^{-1} $ for 6 weeks, accelerated bone formation and maturation (thicker trabeculae; most signific","[599, 1349, 1093, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,footer,"Small Sci. 2024, 4, 2300303","[93, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,13,footer,2300303 (8 of 25),"[401, 1476, 541, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,14,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[680, 1479, 1091, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,15,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 29, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 32, 318, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,small science,"[1014, 13, 1098, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +9,2,header,www.small-science-journal.com,"[884, 86, 1097, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,3,text,"hydroxyapatite (HA) but not around tricalcium phosphate (TCP) implants.[91] Moreover, HA tibial implants stimulated with PEMF of higher pulse frequency and MF strength (50 Hz, 8 mT), for 0.5 h twice-a","[95, 138, 588, 493]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"Implant osseointegration was also evaluated in low BMD conditions, namely in type-1 diabetes mellitus (T1DM) rabbit models and in glucocorticoids-treated rabbits.[87,88] Both studies used the same por","[96, 494, 588, 1027]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,paragraph_title,2.3.3. Tackling Soft Tissue Disorders in Intermediate-Sized Animals via IC Stimulation,"[97, 1052, 587, 1099]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3.3. Tackling Soft Tissue Disorders in Intermediate-Sized ""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +9,6,text,"Regarding soft tissue healing applications, rabbits subjected to patellectomy and further exposed for 0.5 h day $ ^{-1} $ for 8–16 weeks to CMF (alternating stimuli of 76.6 Hz, 0.04 mT; constant stimu","[96, 1119, 589, 1301]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,paragraph_title,2.4. Effects of IC Stimulation on Medium-Sized Animals,"[96, 1327, 527, 1350]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Effects of IC Stimulation on Medium-Sized Animals""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +9,8,text,Dogs (Canis lupus familiaris) were not widely used to assess IC stimulation (Figure 1) but can offer some advantages when studying the bone response to injury and treatments. Their skeleton is similar,"[96, 1371, 588, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,text,"Their skeleton is similar to humans in bone weight, density, +organic and inorganic composition, water fraction, secondary +osteons, epiphyseal fusion after maturity, intracortical remodel- +ing activity","[604, 138, 1098, 362]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,10,paragraph_title,2.4.1. Managing Bone Defects in Medium-Sized Animals Through IC Stimulation,"[607, 388, 1091, 435]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4.1. Managing Bone Defects in Medium-Sized Animals Through""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +9,11,text,"The earliest evidence of PEMF effects on bone dates back to 1974 with a study on bone defects, when dog fibular osteotomies were stimulated for 24 h day $ ^{-1} $ with PEMF of 1 or 65 Hz over 4 weeks.","[604, 456, 1098, 678]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,12,text,"Other findings in dogs also support the use of PEMF to repair bone defects and improve the success rate of bone (spine) fusion. $ ^{[62,131]} $ Exposure of osteotomized tibiae for 1 h day $ ^{-1} $ to","[604, 678, 1098, 1011]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,13,paragraph_title,2.4.2. IC Stimulation of Medium-Sized Animals with Osteoporosis and Cartilage Defects,"[606, 1037, 1092, 1085]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4.2. IC Stimulation of Medium-Sized Animals with Osteoporo""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +9,14,text,"In OVX osteoporosis dog models, PEMF of 1.5 Hz for 1 h day $ ^{-1} $ during 12 weeks reduced bone loss from 23.1% to 9.5%, but had no effect on bone remodeling within the bone cortex. $ ^{[132]} $ For","[604, 1104, 1099, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,15,footer,"Small Sci. 2024, 4, 2300303","[98, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,16,footer,2300303 (9 of 25),"[406, 1476, 547, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,17,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[686, 1479, 1097, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,18,aside_text,"26884046, 2024, 5. Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 22, 1172, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +10,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 31, 311, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,small science,"[1009, 13, 1092, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +10,2,header,www.small-science-journal.com,"[878, 86, 1090, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,3,paragraph_title,2.4.3. IC Musculoskeletal Studies on Medium-Sized Animals Showing No Improvement,"[91, 140, 534, 188]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4.3. IC Musculoskeletal Studies on Medium-Sized Animals Sh""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,4,text,"Studies that did not report any IC-driven improvements in dogs' bone metabolism have tested the effects of i) a PEMF of 1.5 Hz, 0.1 mT, 0.5 or 1 h day $ ^{-1} $ for 12 weeks, on spine fusion rate and ","[90, 207, 583, 457]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,paragraph_title,2.5. Findings from IC Pre-Clinical Studies,"[601, 140, 920, 163]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Findings from IC Pre-Clinical Studies""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,6,text,"Pre-clinical studies in non-human animal models have gathered evidence on the benefits of IC stimulation to treat bone and cartilage disorders, as illustrated in Figure 3. These included faster callus","[598, 183, 1093, 457]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,image,,"[109, 506, 715, 919]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,8,image,,"[747, 484, 1077, 919]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,9,image,,"[125, 941, 486, 1183]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,10,image,,"[556, 944, 832, 1180]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,11,image,,"[837, 954, 1079, 1181]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,12,figure_title,Figure 3. Examples of biological outcomes commonly assessed in IC stimulation studies using animal models. A) Improved trabecular bone microarchitecture and cortical bone thickness of femurs of rats s,"[88, 1197, 1095, 1439]",figure_caption,0.92,"[""figure_title label: Figure 3. Examples of biological outcomes commonly assessed ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +10,13,footer,"Small Sci. 2024, 4, 2300303","[94, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,14,number,2300303 (10 of 25),"[396, 1476, 545, 1499]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,15,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[681, 1479, 1090, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,16,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 30, 1171, 1536]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +11,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 32, 317, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header,small science,"[1015, 14, 1098, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +11,2,header,www.small-science-journal.com,"[884, 86, 1097, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,3,text,"properties, including bone bending stiffness, callus/bone elastic modulus, torque and load bearing, have also improved upon IC stimulation. At a molecular/biochemical level, IC stimulation activated o","[96, 139, 588, 315]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"A general overview of IC stimulation efficacy in animal studies is presented in Figure 2, which presents improvements versus no improvements according to stimuli frequency, MF strength or exposure tim","[96, 316, 588, 756]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"Overall, whenever biological outcomes were assessed, IC stimulation induced improvements in more than 75% of the assays, regardless of the assessed outcome (Figure 4A). Nevertheless, radiological and ","[96, 758, 588, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,"modalities that still require optimization, like RMF, or to the rel- +atively lower frequencies, field strengths, or exposure times used +(Table S1, Supporting Information). Of note, CMF and PEMF +were di","[605, 139, 1098, 293]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"In general, the studies applying IC stimulation to animal models revealed promising success rates, although radiological and biomechanical outcomes should be more thoroughly assessed. The available da","[605, 294, 1098, 518]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,8,paragraph_title,3. Clinical Studies of IC Therapies 3.1. Overview of IC Clinical Designs,"[606, 557, 942, 619]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Clinical Studies of IC Therapies 3.1. Overview of IC Clin""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +11,9,footer,,"[606, 595, 888, 619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +11,10,text,The clinical application of IC stimulation to treat multiple complications has been under development since the middle of the $ 20^{th} $ century. This therapeutic is gaining increasing popularity in,"[605, 639, 1098, 928]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,text,IC clinical studies mainly used devices delivering PEMF (in 88.6% of the studies) (Figure 5A). FDA-approved stimulators are the most used devices to test the efficacy of IC musculoskeletal therapy in ,"[604, 928, 1098, 1305]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,12,text,"Regarding the IC stimuli parameters applied in clinical studies (Figure 6A–D), there is first to highlight that the clinical studies reported less frequently the stimuli parameters applied than the pr","[604, 1305, 1098, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,13,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,14,footer,2300303 (11 of 25),"[402, 1476, 551, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,15,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1097, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,16,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +12,0,header,"ADVANCED SCIENCE NEWS_ +www.advancedsciencenews.com","[92, 31, 310, 105]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,small science,"[1009, 14, 1092, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +12,2,header,www.small-science-journal.com,"[878, 87, 1090, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,3,chart,,"[166, 142, 499, 492]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +12,4,figure_title,B Radiological outcomes in animal models,"[537, 143, 903, 164]",figure_caption,0.85,"[""figure_title label: B Radiological outcomes in animal models""]",figure_caption,0.85,body_zone,legend_like,none,True,True +12,5,chart,,"[515, 164, 1020, 497]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +12,6,figure_title,C,"[257, 513, 276, 532]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,7,figure_title,Histological/Biochemical outcomes in animal models,"[346, 514, 732, 533]",figure_caption_candidate,0.85,"[""figure_title label: Histological/Biochemical outcomes in animal models""]",figure_caption,0.85,body_zone,legend_like,none,False,False +12,8,chart,,"[258, 542, 875, 887]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +12,9,figure_title,D Biomechanical outcomes in animal models,"[262, 902, 664, 924]",figure_caption,0.85,"[""figure_title label: D Biomechanical outcomes in animal models""]",figure_caption,0.85,body_zone,legend_like,none,True,True +12,10,chart,,"[263, 936, 792, 1238]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +12,11,figure_title,"Figure 4. Efficacy analysis of IC stimulation parameters (magnetic field and frequency) on pre-clinical studies with animal models, based on the bone-associated outcomes reported. A) Overview of the I","[91, 1267, 1092, 1408]",figure_caption,0.92,"[""figure_title label: Figure 4. Efficacy analysis of IC stimulation parameters (ma""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +12,12,footer,"Small Sci. 2024, 4, 2300303","[94, 1479, 260, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,13,number,2300303 (12 of 25),"[396, 1476, 545, 1499]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,14,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[681, 1479, 1091, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,15,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smse.202900303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 27, 1171, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +13,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 31, 318, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,header_image,,"[1015, 14, 1098, 80]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +13,2,header,www.small-science-journal.com,"[884, 87, 1097, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,3,figure_title,A IC stimulation methods in humans,"[264, 145, 541, 172]",figure_caption_candidate,0.85,"[""figure_title label: A IC stimulation methods in humans""]",figure_caption,0.85,body_zone,body_like,none,False,False +13,4,chart,,"[274, 179, 535, 415]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +13,5,figure_title,B Devices used in human studies,"[617, 144, 884, 170]",figure_caption_candidate,0.85,"[""figure_title label: B Devices used in human studies""]",figure_caption,0.85,body_zone,body_like,none,False,False +13,6,chart,,"[606, 205, 931, 414]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +13,7,figure_title,C,"[264, 446, 284, 467]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +13,8,figure_title,Musculoskeletal conditions assessed in humans,"[425, 451, 776, 471]",figure_caption_candidate,0.85,"[""figure_title label: Musculoskeletal conditions assessed in humans""]",figure_caption,0.85,body_zone,legend_like,none,False,False +13,9,chart,,"[298, 481, 927, 709]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +13,10,figure_title,D,"[277, 724, 295, 745]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +13,11,image,,"[319, 731, 491, 854]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,12,figure_title,F,"[503, 724, 519, 746]",figure_inner_text,0.9,"[""panel label / figure inner text: F""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +13,13,figure_title,E,"[277, 854, 295, 875]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +13,14,image,,"[319, 863, 491, 1048]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,15,image,,"[506, 733, 717, 1046]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +13,16,figure_title,"Figure 5. General trends of IC clinical stimulation in clinical studies. Types of A) IC stimulation applied, and B) Stimulation devices used in human patients. ""Approved devices"" refer to stimulators ","[97, 1060, 1100, 1223]",figure_caption,0.92,"[""figure_title label: Figure 5. General trends of IC clinical stimulation in clini""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +13,17,text,"information. In the fewer clinical studies that could be analyzed here, the stimuli pulse frequencies ranged from 1.5–80 Hz, with a high prevalence of 15 Hz, the frequency used in 44.1% of the studies","[96, 1263, 588, 1423]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,18,text,"These highly varied from 6 μT to 5 mT (except for a higher MF +strength of 105 mT), although 45.4% (10 out of 22 studies) +applied MF strengths between 1.0 and 3.0 mT. The daily expo- +sure time ranged f","[604, 1263, 1098, 1422]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,19,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,20,footer,2300303 (13 of 25),"[402, 1476, 551, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,21,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1097, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,22,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 29, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +14,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 31, 312, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,1,header,small science,"[1008, 13, 1092, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +14,2,header,www.small-science-journal.com,"[878, 86, 1091, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,3,figure_title,A,"[271, 142, 290, 162]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +14,4,chart,,"[282, 142, 568, 505]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +14,5,chart,,"[584, 140, 902, 505]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +14,6,figure_title,D,"[584, 512, 603, 533]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +14,7,chart,,"[272, 512, 561, 865]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +14,8,chart,,"[592, 519, 900, 866]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +14,9,figure_title,"Figure 6. IC stimuli parameters applied in clinical studies. Types of IC stimulation parameters used on patients with musculoskeletal disorders, number of studies in which they were used, and their re","[89, 879, 1095, 1042]",figure_caption,0.92,"[""figure_title label: Figure 6. IC stimuli parameters applied in clinical studies.""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +14,10,text,"durations varied from 6 days to 18 months, with a median of 3 months and an average of 5.4 months.","[90, 1076, 584, 1122]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,11,paragraph_title,3.2. Evidence of IC Clinical Efficacy in Humans,"[91, 1150, 454, 1172]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Evidence of IC Clinical Efficacy in Humans""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,12,text,"Regarding the type of non-invasive biological/clinical outcome measures used to assess the efficacy of IC stimulation, radiological imaging outcomes were the ones mainly assessed in almost all the cli","[90, 1194, 582, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,13,paragraph_title,3.2.1. Managing Bone Defects in Humans with IC Stimulation,"[602, 1079, 1063, 1101]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.1. Managing Bone Defects in Humans with IC Stimulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,14,text,"Success when treating bone defects, like delayed unions and non-unions, was obtained upon stimulation with PEMF (and CMF) of 15, 23, or 80 Hz pulses, 0.01–2 mT, applied for 8–24 h day $ ^{-1} $, since","[599, 1123, 1093, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,15,footer,"Small Sci. 2024, 4, 2300303","[94, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,16,footer,2300303 (14 of 25),"[396, 1476, 545, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +14,17,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[680, 1479, 1091, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,18,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smse.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 29, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +15,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 31, 318, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,header,small science,"[1015, 14, 1098, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +15,2,header,www.small-science-journal.com,"[883, 86, 1097, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,3,figure_title,A,"[245, 143, 264, 163]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,4,chart,,"[282, 143, 774, 491]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +15,5,chart,,"[244, 514, 954, 1106]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +15,6,figure_title,"Figure 7. Analysis of the efficacy of the IC in vivo stimulation parameters (magnetic field and frequency) on human patients, based on the reported bone-associated outcomes. A) Overview of the IC effi","[97, 1118, 1099, 1261]",figure_caption,0.92,"[""figure_title label: Figure 7. Analysis of the efficacy of the IC in vivo stimula""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +15,7,text,"1007 ununited fractures. Similar success rates were obtained when comparing PEMF against surgery with bone grafts, to treat ununited tibial fractures. Aaron et al. $ ^{[162]} $ (2004) concluded that b","[96, 1301, 588, 1437]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +15,8,text,"intervention could have evolved more over the last decades, still +highlighting the lack of setup optimization and/or personalized +medicine studies.","[605, 1300, 1097, 1367]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,9,text,"Examples of setups with positive osteogenic effects include the EBI Bone Healing System Model 420 (15 Hz pulses, 4.5 kHz bursts, 8–10 h day $ ^{-1} $) to treat scaphoid non-unions, which","[605, 1368, 1098, 1436]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,10,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 266, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,11,footer,2300303 (15 of 25),"[403, 1476, 551, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +15,12,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1096, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,13,aside_text,"26884046, 2024, 5. Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 28, 1171, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +16,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 32, 311, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,1,header,small science,"[1008, 13, 1092, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +16,2,header,www.small-science-journal.com,"[878, 86, 1091, 107]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,3,text,"resulted in better grip and wrist motion unto 83% and 89% of normal levels, respectively.[141] However, in a follow-up study 6 years later, using the same settings, results slightly decreased to 77% a","[90, 137, 583, 622]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,4,text,"PEMF efficacy was also tested in acute bone fractures. PEMF of 40–72 Hz, 1 mT, applied 2–6 h day $ ^{-1} $ after mandibular fracture, complemented with maxillo-mandibular fixation, was able to return ","[90, 623, 583, 1130]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,5,text,"Regarding spine fusion, some studies state that both PEMF (4–8 h day $ ^{-1} $) and CMF (30 min day $ ^{-1} $) can improve the surgery's success rate by up to 48.8% $ ^{[145,175,176]} $. In contrast, ","[90, 1129, 582, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,text,"hypothesis, a recent multicenter study on the use of PEMF as +an adjuvant therapy to lumbar spine fusion in 142 patients at risk +for pseudarthrosis (Orthofix SpinalStim, 1.5 Hz pulses, 3.85 kHz +bursts, ","[598, 137, 1093, 473]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,7,paragraph_title,3.2.2. Tackling Osteoporosis in Humans Through IC Stimulation,"[602, 499, 1076, 523]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.2. Tackling Osteoporosis in Humans Through IC Stimulatio""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +16,8,text,"In post-menopausal women prone to osteoporosis and taking calcium and vitamin D supplements, a 40 min day $ ^{-1} $ thrice-a-week treatment with PEMF of 8 Hz pulses and 3.82 mT only slightly increased","[598, 543, 1093, 1187]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,9,paragraph_title,3.2.3. Enhancing Implant Osseointegration in Humans via IC Stimulation,"[601, 1215, 1055, 1261]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.3. Enhancing Implant Osseointegration in Humans via IC S""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +16,10,text,"To our knowledge, PEMF efficacy on implants’ osseointegration in humans was only tested in dental and hip prosthesis implants. $ ^{[142,184]} $ For dental implants, PEMF was implemented through caps t","[598, 1281, 1093, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,11,footer,"Small Sci. 2024, 4, 2300303","[93, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,12,footer,2300303 (16 of 25),"[395, 1476, 546, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +16,13,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[679, 1479, 1091, 1499]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,14,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 22, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +17,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 32, 317, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +17,1,header,small science,"[1014, 14, 1098, 80]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +17,2,header,www.small-science-journal.com,"[884, 86, 1097, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +17,3,text,"prosthesis, BMD levels at 0 and 90 post-operative days, were measured on different zones following stimulation with PEMF of 75 Hz, 2.0 mT (6 h day $ ^{-1} $). Although no significant differences were ","[96, 139, 588, 361]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +17,4,paragraph_title,3.2.4. Handling Osteoarthritis in Humans Through IC Stimulation,"[97, 387, 585, 411]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.4. Handling Osteoarthritis in Humans Through IC Stimulat""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +17,5,text,"Only two studies tested the efficacy of PEMF on (knee) osteoarthritis. One study used the FDA-approved MAGCELL ARTHRO device to deliver PEMF of 8 Hz, 105 mT for 5 min twice-a-day, for 15 days, and ati","[96, 431, 588, 742]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +17,6,paragraph_title,3.2.5. Addressing Soft Tissue Disorders in Humans with IC Stimulation,"[97, 767, 528, 815]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2.5. Addressing Soft Tissue Disorders in Humans with IC St""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +17,7,text,"In the only study on IC clinical application for soft tissues reported in the literature, PEMF stimuli of very high frequency (1 kHz pulses, with 27 MHz bursts) could improve soft tissue healing, pain","[96, 835, 588, 950]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +17,8,paragraph_title,3.3. Findings from IC Clinical Studies,"[97, 973, 387, 997]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Findings from IC Clinical Studies""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +17,9,text,"The relative efficacy of the IC clinical studies, according to the applied stimuli parameters, is presented in Figure 6 (global overview for each parameter) and Figure 7, which associates pairs of fre","[95, 1018, 587, 1129]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +17,10,text,"First, no clinical study has reported major adverse effects from the use of IC stimulation devices. Studies assessing radiographic outcomes (examples illustrated in Figure 8) have reported effects dri","[96, 1129, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +17,11,text,"low efficacy for treating scaphoid non-unions and delayed unions +after foot and ankle arthrodesis, and effectiveness on bone frac- +tures highly varied. Indeed, various setups did not significantly +impro","[604, 137, 1098, 360]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +17,12,text,"Many authors did not report the IC parameters used in their studies, making it difficult to draw more assertive conclusions regarding effective magnetic stimuli settings. However, most of them used cl","[605, 360, 1098, 779]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +17,13,text,"Altogether, the use of IC stimulation seems clinically feasible to treat non-unions, to reduce its risk after fracture and accelerate healing when combined with standard procedures, and to increase th","[605, 778, 1098, 1066]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +17,14,text,"Overall, this study indicates that it would be desirable to develop more attractive devices for daily use, with the ability to provide personalized stimuli, and highlights the need to comprehensively ","[605, 1065, 1099, 1178]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +17,15,paragraph_title,4. The Potential Biomechanism Behind IC Therapeutic Effects,"[606, 1212, 1018, 1266]",unknown_structural,0.85,"[""paragraph_title label with numbering: 4. The Potential Biomechanism Behind IC Therapeutic Effects""]",section_heading,0.85,reference_zone,reference_like,reference_numeric_dot,False,True +17,16,text,"At the turn of the 21 $ ^{st} $ century, various groups started attempting to infer the biomechanisms underlying the IC effects on the musculoskeletal system, with this line of research accelerating i","[604, 1282, 1099, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +17,17,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +17,18,footer,2300303 (17 of 25),"[402, 1476, 552, 1499]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +17,19,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[686, 1479, 1097, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +17,20,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 29, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +18,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 32, 312, 105]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +18,1,header,small science,"[1008, 13, 1092, 80]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +18,2,header,www.small-science-journal.com,"[878, 86, 1091, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +18,3,image,,"[189, 137, 994, 1132]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +18,4,figure_title,Figure 8. Examples of biological outcomes assessed in IC stimulation studies in humans. A) Anteroposterior and lateral radiographs of a distal tibial nonunion: i) 10 months after fracture; ii) after P,"[90, 1149, 1093, 1293]",figure_caption,0.92,"[""figure_title label: Figure 8. Examples of biological outcomes assessed in IC sti""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +18,5,text,"storages, increasing the cytosolic Ca²⁺ concentration. This potentially occurs through the activation of ryanodine-dependent Ca²⁺ channels (RyR) or inositol 1,4,5-triphosphate receptors (IP₃R) of the ","[90, 1326, 581, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +18,6,text,"coupled with the activation of voltage-sensitive enzymes, +the reorganization of the cytoskeleton, and the activation of +Ca2þ-dependent enzymes, including calmodulin (CaM).[190] +In osteoblasts, calcine","[599, 1326, 1093, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +18,7,footer,"Small Sci. 2024, 4, 2300303","[94, 1479, 260, 1498]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,8,footer,2300303 (18 of 25),"[396, 1476, 545, 1499]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +18,9,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[680, 1479, 1091, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +18,10,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smse.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 30, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +19,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 32, 317, 105]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +19,1,header,small science,"[1015, 14, 1098, 81]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +19,2,header,www.small-science-journal.com,"[884, 87, 1097, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +19,3,image,,"[147, 141, 1052, 672]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +19,4,figure_title,Figure 9. Biomechanisms that may underly the observed therapeutic bone-associated effects of inductive coupling (IC) in vivo stimulation. The electromagnetic fields (EMF) delivered by IC pass the cyto,"[95, 693, 1102, 877]",figure_caption,0.92,"[""figure_title label: Figure 9. Biomechanisms that may underly the observed therap""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +19,5,text,"Factor of Activated T Cells 1 (NFATc1), promoting its nuclear translocation and a subsequent increase in the transcription of genes related to the Wnt/ $ \beta $-catenin pathway. $ ^{[192]} $ Followin","[96, 916, 589, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +19,6,text,"increased sAC, serum cAMP, p-PKA and p-CREB.[102,121] +This sequence of events promotes osteoblastogenic effects, for +example by allowing the accumulation of β-catenin[201] and thus +cross-talking with ","[604, 914, 1099, 1137]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +19,7,text,"In contrast, IC stimulation can also regulate osteoclast differentiation and activity, by increasing the OPG/RANKL ratio. The increase in OPG expression, together with a decrease in RANKL expression, ","[604, 1139, 1099, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +19,8,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,9,footer,2300303 (19 of 25),"[402, 1476, 552, 1499]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +19,10,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1097, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +19,11,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1153, 29, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +20,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 32, 311, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +20,1,header,small science,"[1008, 14, 1092, 81]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,2,header,www.small-science-journal.com,"[878, 86, 1091, 107]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +20,3,text,"of bone resorption, and thus a decrease in serum CTX. $ ^{[87,88,102,112,120,121,126,180]} $ Netrin 4 may also play a role in the PEMF-induced decrease of osteoclastogenesis, $ ^{[202]} $ since PEMF i","[90, 138, 582, 359]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,4,text,"In vitro experiments suggest two other parallel and interacting mechanisms of action by which IC may lead to decreased osteoclast and increased osteoblast activities. PEMF was observed to induce, at a","[89, 360, 582, 1025]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,5,text,"In summary, there are various possible cellular events by which IC stimuli modulate osteogenic and osteoclastic activities to increase bone formation and decrease bone resorption, underscoring IC ther","[89, 1024, 582, 1293]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,6,paragraph_title,5. General Conclusions and Future Perspectives,"[90, 1328, 561, 1355]",section_heading,0.85,"[""paragraph_title label with numbering: 5. General Conclusions and Future Perspectives""]",section_heading,0.85,,heading_like,heading_numbered,True,True +20,7,text,"This review analyzed 117 studies (73 in animal models, and 44 in human patients) using magnetic stimulation delivered by IC devices for musculoskeletal therapy purposes. Overall, from the studies here","[90, 1371, 582, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +20,8,text,"www.small-science-journal.com +the studies here analyzed, IC stimulation is an attractive option +for the clinical management of bone and cartilage disorders. IC is +a non-invasive therapy, with the MF b","[597, 140, 1093, 1305]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +20,9,text,"Hopefully, the transversal knowledge presented herein will serve as a valuable guide as we navigate the path toward optimizing clinical evidence and personalized IC-based treatment strategies. A deepe","[598, 1306, 1093, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +20,10,footer,"Small Sci. 2024, 4, 2300303","[93, 1479, 261, 1498]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,11,footer,2300303 (20 of 25),"[396, 1476, 545, 1499]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +20,12,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[680, 1479, 1091, 1498]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,13,aside_text,"26884046, 2024, 5. Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smse.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 29, 1171, 1541]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +21,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[99, 32, 317, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +21,1,header,small science,"[1015, 14, 1098, 80]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +21,2,header,www.small-science-journal.com,"[884, 87, 1097, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +21,3,text,"devices, will be vital for pushing forward the clinical implementation and achieve the full therapeutic potential of IC stimulation for musculoskeletal disorders, toward more effective and tailored pa","[97, 138, 587, 228]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,4,paragraph_title,Supporting Information,"[98, 266, 329, 292]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supporting Information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True +21,5,text,Supporting Information is available from the Wiley Online Library or from the author.,"[97, 302, 586, 341]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,6,paragraph_title,Acknowledgements,"[98, 381, 288, 406]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +21,7,text,"J.G.S.F. and B.M.de.S. contributed equally to this work. The authors acknowledge the support of Fundação para a Ciência e Tecnologia (Portugal), Centro 2020, the COMPETE program, QREN, and the Europea","[96, 417, 588, 666]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +21,8,paragraph_title,Conflict of Interest,"[98, 704, 284, 729]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +21,9,text,The authors declare no conflict of interest.,"[98, 741, 390, 761]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +21,10,paragraph_title,Keywords,"[99, 814, 195, 839]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Keywords""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +21,11,text,"animal models, clinical studies, combined magnetic fields (CMF), inductive coupling, musculoskeletal disorders, pre-clinical studies, pulsed electromagnetic fields (PEMF)","[97, 850, 586, 910]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,12,text,"Received: November 21, 2023","[381, 922, 586, 941]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,13,text,"Revised: February 5, 2024","[408, 943, 587, 961]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,14,text,"Published online: February 26, 2024","[341, 962, 586, 982]",backmatter_body,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,True,True +21,15,reference_content,"[1] T. 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Silva, M. de Lourdes Noronha Motta""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +24,59,reference_content,"[210] R. Bernardo, A. Rodrigues, M. P. Soares dos Santos, P. Carneiro, A. Lopes, J. Sequeira Amaral, V. Sequeira Amaral, R. Morais, Med. Eng. Phys. 2019, 73, 77.","[604, 1290, 1089, 1349]",reference_item,0.85,"[""reference content label: [210] R. Bernardo, A. Rodrigues, M. P. Soares dos Santos, P.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +24,60,reference_content,"[211] T. S. S. Carvalho, P. M. C. Torres, J. H. Belo, J. Mano, S. M. Olhero, Adv. NanoBiomed Res. 2023, 3, 2300035.","[604, 1351, 1090, 1389]",reference_item,0.85,"[""reference content label: [211] T. S. S. Carvalho, P. M. C. Torres, J. H. Belo, J. Man""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +24,61,footer,"Small Sci. 2024, 4, 2300303","[94, 1479, 260, 1497]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +24,62,footer,2300303 (24 of 25),"[396, 1477, 545, 1499]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +24,63,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[681, 1479, 1091, 1498]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +24,64,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1155, 34, 1171, 1537]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +25,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 32, 318, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +25,1,header,small science,"[1014, 14, 1098, 81]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +25,2,header,www.small-science-journal.com,"[884, 86, 1097, 106]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +25,3,image,,"[112, 150, 261, 343]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +25,4,figure_title,"José G. S. Figueiredo is a Ph.D. student of Rehabilitation Sciences at Institute of Biomedicine (iBiMED), Department of Medical Sciences of the University of Aveiro, since 2022 and a research fellow a","[270, 144, 1067, 301]",figure_caption,0.85,"[""figure_title label: Jos\u00e9 G. S. Figueiredo is a Ph.D. student of Rehabilitation S""]",figure_caption,0.85,,legend_like,none,True,True +25,5,image,,"[117, 357, 262, 549]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +25,6,text,"Bárbara M. de Sousa holds a BSc in Biomedical Sciences and a MSc in Biochemistry and is currently a Ph.D. student in Biomedicine (University of Aveiro, Portugal). Bárbara's research interests revolve ","[271, 354, 1077, 489]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,,unknown_like,none,True,True +25,7,image,,"[116, 564, 264, 762]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +25,8,text,"Marco P. Soares dos Santos is assistant professor at the Department of Mechanical Engineering of the University of Aveiro, Portugal, since 2020. He graduated in Electrical and Computers Engineering fr","[270, 561, 1076, 720]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,citation_line,True,True +25,9,image,,"[117, 771, 262, 967]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +25,10,text,"Sandra I. Vieira is an assistant professor at the Department of Medical Sciences of the University of Aveiro, Portugal. She has graduated in Biochemistry from the University of Porto, Portugal (1998),","[270, 770, 1067, 928]",reference_item,0.82,"[""default body_paragraph for text label"", ""late role resolution: reference_like family + reference zone"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,citation_line,True,True +25,11,footer,"Small Sci. 2024, 4, 2300303","[99, 1479, 267, 1498]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +25,12,footer,2300303 (25 of 25),"[402, 1476, 551, 1499]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +25,13,footer,© 2024 The Authors. Small Science published by Wiley-VCH GmbH,"[687, 1479, 1097, 1499]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +25,14,aside_text,"26884046, 2024, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/smsc.202300303 by CochraneChina, Wiley Online Library on [19/07/2025]. See the Terms and Conditions (https://onlinelibrar","[1154, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/4AGGTJE9/block_trace.csv b/tests/fixtures/ocr_real_papers/4AGGTJE9/block_trace.csv new file mode 100644 index 00000000..bfdda572 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/4AGGTJE9/block_trace.csv @@ -0,0 +1,52 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,2013 39th Annual Northeast Bioengineering Conference,"[381, 85, 842, 111]",noise,0.9,"[""header label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,1,doc_title,"Rheological Analysis of Hydrogel Composites +Containing Carbon Nanobrushes","[183, 157, 1039, 257]",paper_title,0.8,"[""page-1 zone title_zone: Rheological Analysis of Hydrogel Composites\nContaining Carbo""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,2,text,"William H. Marks¹, Tunc Kiymaz¹, Sze C. Yang², George W. Dombi², Sujata K. Bhatia¹ +¹Harvard University, School of Engineering and Applied Sciences, Cambridge, Massachusetts, USA 02138 +²University of R","[197, 293, 1021, 390]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: William H. Marks\u00b9, Tunc Kiymaz\u00b9, Sze C. Yang\u00b2, George W. Dom""]",frontmatter_noise,0.8,body_zone,reference_like,citation_line,False,False +1,3,abstract,"Abstract—The objective of this work is to examine the rheological properties of hydrogel composites containing carbon nanobrushes. The composite, which is electrically conductive, is comprised of carb","[107, 412, 597, 869]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,4,abstract,Keywords - carbon nanobrushes; poloxamer hydrogel; rheometry; conductive hydrogel; tissue engineering; wound healing,"[107, 888, 596, 953]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,unknown_like,none,True,True +1,5,paragraph_title,I. INTRODUCTION,"[261, 967, 457, 988]",section_heading,0.9,"[""explicit scholarly heading: I. INTRODUCTION""]",section_heading,0.9,body_zone,unknown_like,heading_roman,True,True +1,6,text,"Hydrogels mimic in vivo environments by providing three-dimensional encapsulating scaffolds in which cells can proliferate, maintain normal functioning, and allow for tissue growth [1]. Pluronic F-127","[106, 996, 596, 1208]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,7,text,Kawaguchi showed that alginate gels containing carbon nanotubes exhibited a mild inflammatory response and no cytotoxicity as a tissue engineering platform $ [5] $; such gels additionally exhibit ele,"[106, 1214, 597, 1383]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,"the mechanical properties of the gel in addition to making the +gels electrically conductive.","[622, 408, 1112, 452]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,9,paragraph_title,II. MATERIALS AND METHODS A. Materials,"[624, 466, 1023, 521]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: II. MATERIALS AND METHODS A. Materials""]",section_heading,0.5,body_zone,unknown_like,none,True,True +1,10,footer,,"[624, 500, 742, 521]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,unknown_like,empty,False,False +1,11,text,"Pluronic F-127 poloxamer (Sigma, USA), carbon nanobrushes (Chemistry Department, University of Rhode Island), Dulbecco's Modified Eagle Medium (DMEM) (Gibco, USA).","[622, 525, 1112, 611]",affiliation,0.8,"[""page-1 zone affiliation_zone: Pluronic F-127 poloxamer (Sigma, USA), carbon nanobrushes (C""]",affiliation,0.8,body_zone,unknown_like,none,True,True +1,12,paragraph_title,B. Construction of carbon nanobrushes,"[625, 621, 947, 643]",subsection_heading,0.9,"[""explicit scholarly heading: B. Construction of carbon nanobrushes""]",subsection_heading,0.9,body_zone,heading_like,heading_alpha,True,True +1,13,text,The carbon nanobrushes (CNB) were constructed by coating carbon nanotubes with a polyaryl polymer brush. The size of the CNB ranges from 5-20µm in length. The diameter of the CNB is 15-30nm. The CNB w,"[622, 647, 1113, 754]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,paragraph_title,C. Preparation of poloxamer solution,"[625, 764, 932, 786]",section_heading,0.9,"[""explicit scholarly heading: C. Preparation of poloxamer solution""]",section_heading,0.9,body_zone,heading_like,heading_roman,True,True +1,15,text,"The poloxamer solution was prepared as both a 30wt% and 35wt% poloxamer solution. First, pluronic F-127 poloxamer was dissolved in 4°C de-ionized, de-gassed water to make 30wt% and 35wt% solutions whi","[622, 790, 1114, 980]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,paragraph_title,D. Preparation of poloxamer hydrogels with carbon nanobrushes,"[624, 990, 1040, 1032]",section_heading,0.9,"[""explicit scholarly heading: D. Preparation of poloxamer hydrogels with carbon nanobrushe""]",section_heading,0.9,body_zone,heading_like,heading_roman,True,True +1,17,text,"The poloxamer hydrogels were prepared by pipetting 5mL of solution into each well in a six well plate. Different wells were prepared with different concentrations of CNB, including 0vol%, 0.1vol%, 0.5","[622, 1038, 1113, 1227]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,18,paragraph_title,E. Observation of cellular density and health,"[624, 1238, 989, 1259]",subsection_heading,0.9,"[""explicit scholarly heading: E. Observation of cellular density and health""]",subsection_heading,0.9,body_zone,heading_like,heading_alpha,True,True +1,19,text,Fibroblast and myocyte density and health was observed by optical microscopy at various layers of the poloxamer hydrogels after 24 and 48 hours. Visualization was performed through a VWR VistaVision I,"[622, 1263, 1114, 1370]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,footnote,Harvard School of Engineering and Applied Sciences,"[133, 1423, 468, 1444]",footnote,0.7,"[""footnote label: Harvard School of Engineering and Applied Sciences""]",footnote,0.7,body_zone,unknown_like,none,True,True +1,21,footer,978-0-7695-4964-4/13 $26.00 © 2013 IEEE DOI 10.1109/NEBEC.2013.134,"[95, 1478, 387, 1519]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,unknown_like,none,False,False +1,22,number,109,"[598, 1480, 627, 1498]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +1,23,footer_image,,"[996, 1472, 1102, 1513]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +2,0,paragraph_title,III. RESULTS AND DISCUSSION A. Frequency sweep testing of hydrogels,"[107, 141, 504, 198]",paper_title,0.6,"[""page-1 frontmatter title guard: III. RESULTS AND DISCUSSION A. Frequency sweep testing of hy""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +2,1,footer,,"[107, 176, 437, 198]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,empty,False,False +2,2,text,"30wt% and 35wt% poloxamer gels containing 0vol%, 0.1vol%, 0.5vol%, 1vol%, and 5vol% CNB were tested on an TA AR-G2 Rheometer using a 20mm steel plate and controlled temperatures. Frequency sweeps were","[107, 201, 596, 288]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,chart,,"[112, 294, 589, 618]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,display_zone,unknown_like,empty,True,True +2,4,figure_title,Figure 1. Frequency sweep of 30wt% and 35wt% F127 hydrogels with varying concentrations of CNB.,"[127, 633, 575, 669]",figure_caption,0.92,"[""figure_title label: Figure 1. Frequency sweep of 30wt% and 35wt% F127 hydrogels ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,5,text,"Analysis of the rheometry data shows a similar pattern in both the 30wt% and 35wt% poloxamer gels. The addition of CNB to the hydrogels, from 0vol% to 5vol% CNB, alters the material properties of the ","[107, 687, 598, 897]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +2,6,text,"The crossover point for these hydrogel composites is just below 0.02 rad/s for both the 30wt% and 35wt% hydrogels. However, the differences between the two composites tested shows how hydrogel concent","[107, 906, 596, 1135]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +2,7,paragraph_title,IV. CONCLUSION,"[268, 1151, 444, 1171]",section_heading,0.9,"[""explicit scholarly heading: IV. CONCLUSION""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,heading_roman,True,True +2,8,text,This work demonstrates that CNB can be successfully dispersed into pluronic F127 poloxamer gels. This work also demonstrates the affect that hydrogel concentration has on the mechanical characteristic,"[107, 1178, 597, 1242]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +2,9,text,"mechanical characteristics of hydrogel composites containing +CNB. Moreover, this work demonstrates that chondrocyte +cells can likely survive and proliferate in 30wt% and 35wt% +poloxamer gels containin","[621, 143, 1113, 562]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,ACKNOWLEDGMENTS,"[783, 575, 953, 594]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,unknown_like,short_fragment,True,True +2,11,text,The team thanks the laboratory of David Weitz and the Rheology Center for rheometer instruction and access.,"[624, 604, 1110, 647]",affiliation,0.8,"[""page-1 zone affiliation_zone: The team thanks the laboratory of David Weitz and the Rheolo""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +2,12,paragraph_title,REFERENCES,"[816, 664, 920, 683]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +2,13,reference_content,"[1] Nicola C. Hunt and Liam M. Grover, ""Cell encapsulation using biopolymer gels for regenerative medicine,"" Biotechnol Lett, vol. 32, pp. 733-742, 2010.","[625, 692, 1109, 742]",reference_item,0.85,"[""reference content label: [1] Nicola C. Hunt and Liam M. Grover, \""Cell encapsulation u""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +2,14,reference_content,"[2] William H. Marks, Sze C. Yang, George W. Dombi, and Sujata K. Bhatia, “Translational Potential for Hydrogel Composites Containing Carbon Nanobrushes,” Proceedings of the IEEE 38 $ ^{th} $ Annual N","[626, 747, 1109, 815]",reference_item,0.85,"[""reference content label: [2] William H. Marks, Sze C. Yang, George W. Dombi, and Suja""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +2,15,reference_content,"[3] William H. Marks, Sze C. Yang, George W. Dombi, and Sujata K. Bhatia, “Hydrogel Composites Containing Carbon Nanobrushes for Wound Healing Applications,” Proceedings of the 6 $ ^{th} $ Internation","[626, 821, 1109, 907]",reference_item,0.85,"[""reference content label: [3] William H. Marks, Sze C. Yang, George W. Dombi, and Suja""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +2,16,reference_content,"[4] William H. Marks, Sze C. Yang, George W. Dombi, and Sujata K. Bhatia, “Interactions of Poloxamer Hydrogel Composites Containing Carbon Nanobrushes With Clinically Relevant Cell Lines,” Proceedings","[625, 911, 1109, 996]",reference_item,0.85,"[""reference content label: [4] William H. Marks, Sze C. Yang, George W. Dombi, and Suja""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +2,17,reference_content,"[5] Minoru Kawaguchi et al., “Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering,” Dental Materials Journal, vol 25 (4), pp. 719-725, 2006.","[626, 1001, 1108, 1053]",reference_item,0.85,"[""reference content label: [5] Minoru Kawaguchi et al., \u201cPreparation of carbon nanotube""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +2,18,reference_content,"[6] C. Basavaraja, Bong Seong Kim and Do Sung Huh, ""Characterization and AC Electrical Conductivity for the Dispersed Composites Containing Alginate-Multiwalled Carbon Nanotubes,"" Macromolecular Resea","[625, 1057, 1109, 1126]",reference_item,0.85,"[""reference content label: [6] C. Basavaraja, Bong Seong Kim and Do Sung Huh, \""Characte""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +2,19,number,110,"[599, 1480, 627, 1498]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/4CG7FRN7/block_trace.csv b/tests/fixtures/ocr_real_papers/4CG7FRN7/block_trace.csv new file mode 100644 index 00000000..3eeb07e6 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/4CG7FRN7/block_trace.csv @@ -0,0 +1,565 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[86, 50, 295, 123]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header,ORIGINAL RESEARCH published: 04 September 2018 doi: 10.3389/fphys.2018.00974,"[907, 67, 1105, 120]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +1,2,image,,"[1045, 144, 1099, 199]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,3,doc_title,"The Resting Potential and K $ ^{+} $ +Currents in Primary Human Articular +Chondrocytes","[351, 265, 1084, 404]",paper_title,0.8,"[""page-1 zone title_zone: The Resting Potential and K $ ^{+} $\nCurrents in Primary Hum""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"Mary M. Maleckar $ ^{1,2} $, Robert B. Clark $ ^{3} $, Bartholomew Votta $ ^{4} $ and Wayne R. Giles $ ^{5*} $","[350, 429, 1031, 453]",authors,0.8,"[""page-1 zone author_zone: Mary M. Maleckar $ ^{1,2} $, Robert B. Clark $ ^{3} $, Barth""]",authors,0.8,body_zone,reference_like,citation_line,True,True +1,5,text," $ ^{1} $ Simula Research Laboratory, Center for Biomedical Computing and Center for Cardiological Innovation, Oslo, Norway, + $ ^{2} $ Allen Institute for Cell Science, Seattle, WA, United States, $ ","[350, 468, 1088, 550]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ Simula Research Laboratory, Center for Biomedical C""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,6,text,OPEN ACCESS,"[172, 738, 323, 763]",frontmatter_noise,0.7,"[""frontmatter noise text: OPEN ACCESS""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False +1,7,text,"Edited by: +Leonardo Angelone, +United States Food and Drug +Administration, United States","[139, 780, 324, 862]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Edited by:\nLeonardo Angelone,\nUnited States Food and Drug\nAd""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,8,abstract,Human transplant programs provide significant opportunities for detailed in vitro assessments of physiological properties of selected tissues and cell types. We present a semi-quantitative study of th,"[347, 578, 1107, 1165]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,9,text,"Reviewed by: Richard Gray, State Food and Drug Administration, China","[95, 869, 324, 944]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Reviewed by: Richard Gray, State Food and Drug Administratio""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,10,text,"Ali Mobasheri, +University of Surrey, United Kingdom","[96, 943, 324, 990]",frontmatter_noise,0.7,"[""keyword-like block: Ali Mobasheri,\nUniversity of Surrey, United Kingdom""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,11,text,"*Correspondence: +Wayne R. Giles +wgiles@ucalgary.ca","[198, 996, 324, 1057]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: *Correspondence:\nWayne R. Giles\nwgiles@ucalgary.ca""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,12,text,"Specialty section: +This article was submitted to +Computational Physiology and +Medicine, +a section of the journal +Frontiers in Physiology","[131, 1080, 325, 1203]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Specialty section:\nThis article was submitted to\nComputation""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,13,text,"Citation: Maleckar MM, Clark RB, Votta B and Giles WR (2018) The Resting Potential and $ K^{+} $Currents in Primary Human Articular Chondrocytes. Front. Physiol. 9:974. doi: 10.3389/fphys.2018.00974","[88, 1281, 324, 1417]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Maleckar MM, Clark RB, Votta B and Giles WR (2018)""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,14,text,"Received: 13 April 2018 +Accepted: 03 July 2018 +Published: 04 September 2018 +Keywords: human chondrocyte, patch clamp recordings, K⁺ currents, TRP channels, mathematical model, resting membrane potenti","[120, 1211, 324, 1271]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 13 April 2018\nAccepted: 03 July 2018\nPublished: 04""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,15,text,"Keywords: human chondrocyte, patch clamp recordings, K+ currents, TRP channels, mathematical model, resting +membrane potential, depolarization-secretion coupling","[348, 1178, 1106, 1222]",frontmatter_noise,0.7,"[""keyword-like block: Keywords: human chondrocyte, patch clamp recordings, K+ curr""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,16,paragraph_title,INTRODUCTION,"[351, 1256, 546, 1284]",section_heading,0.9,"[""explicit scholarly heading: INTRODUCTION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,17,text,Articular cartilage is a major component of the flexible connective tissue that covers the opposed ends of articular joints. It is essential for the stability and low friction movement of the associat,"[348, 1304, 1107, 1421]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,18,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1481, 353, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,19,number,1,"[589, 1482, 602, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +1,20,footer,September 2018 | Volume 9 | Article 974,"[855, 1480, 1104, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,Maleckar et al.,"[86, 56, 180, 76]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,text,"named a “chondron” (Poole, 1997; Guilak et al., 2006; Nguyen et al., 2010; McLane et al., 2013). Under physiological circumstances, cyclical mechanical forces within the joint capsule create a dynamic","[83, 122, 584, 259]",unknown_structural,0.8,"[""page-1 zone author_zone: named a \u201cchondron\u201d (Poole, 1997; Guilak et al., 2006; Nguyen""]",authors,0.8,body_zone,body_like,none,False,True +2,3,text,"Although chondrocytes occupy only $ \sim $1–10% of the total volume of mammalian articular cartilage (Hall et al., 1996; Archer and Francis-West, 2003), they play essential roles in the homeostasis o","[83, 260, 585, 627]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"In a variety of progressive chronic diseases, or as a consequence of injury, there is chondrocyte damage and related dysfunction (Bush et al., 2003; Martin and Buckwalter, 2003; Bush and Hall, 2005; M","[83, 626, 585, 1201]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,Detailed experimental investigations that address possible functional relationships between chondrocyte electrophysiology and pathophysiology are technically challenging. This is mainly due to the ver,"[82, 1200, 585, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"other experimental data we have developed a mathematical +model based on the fundamental components responsible for +K+ transport in the human chondrocyte. This model is based +mainly on experimental dat","[603, 122, 1106, 237]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,The goals of this paper are: (i) to identify the main K⁺ currents that contribute to the resting membrane potential (ii) to develop the first mathematical model of essential electrophysiological princ,"[603, 237, 1107, 491]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,METHODS,"[605, 513, 737, 541]",section_heading,0.9,"[""explicit scholarly heading: METHODS""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True +2,9,text,"Mammalian chondrocytes express a number of different voltage-and ligand-gated ion channels, together with ion-selective pumps and exchangers as well as intercellular coupling proteins (cf. Barrett-Jol","[602, 560, 1106, 931]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,Experimental Conditions,"[605, 944, 895, 970]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Experimental Conditions""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,11,text,"In the experimental conditions employed in this study, isolated human chondrocytes had $ E_m $ values ranging from -30 to -60 mV when superfused with normal Tyrode's solution and studied using standa","[602, 971, 1107, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,footer,Frontiers in Physiology | www.frontiersin.org,"[85, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,13,number,2,"[588, 1483, 603, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,14,footer,September 2018 | Volume 9 | Article 974,"[854, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,header,Maleckar et al.,"[86, 57, 180, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,paragraph_title,Electrophysiological Studies,"[85, 119, 418, 145]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrophysiological Studies""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,3,text,"For these electrophysiological studies, selected populations of chondrocytes were first plated on pieces of glass coverslips, which were then transferred from the culture dishes to our superfusion cha","[83, 147, 585, 306]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,"Patch pipettes were fabricated from non-heparinized hematocrit capillaries. Patch pipette-filling solutions were either (i) K⁺-rich (KCl) or (ii) Cs⁺-rich (CsCl), depending on the protocol. In most ex","[83, 306, 585, 626]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,"All electrophysiological measurements were made with a Multi-Clamp 700 A patch clamp amplifier (Molecular Devices). Membrane currents and potentials were digitized with a 1,322 A data acquisition syst","[82, 626, 585, 995]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"Transmembrane current values were normalized to cell capacitance, which was measured from the area under the capacitative current transient produced by a +5mV step in membrane potential. Capacitance w","[83, 994, 585, 1200]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"In the second experimental part of this study, after obtaining the data that characterized the predominant $ K^{+} $ currents in enzymatically isolated human chondrocytes, we analyzed TRP channel med","[83, 1199, 585, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"(1:10). These chondrocytes were used up to a maximum of 6 +days after plating and were not passaged. TRP channels were +activated or blocked using proprietary compounds that were +obtained from Glaxo Smi","[603, 122, 1106, 238]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,The Atypical Microenvironment of the Chondrocyte,"[603, 261, 1041, 314]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: The Atypical Microenvironment of the Chondrocyte""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,10,text,"In adult mammals, the chondrocyte cell population is in a physiological environment, the articular joint fluid that differs significantly from that of most other cells in healthy human tissues. A numb","[602, 318, 1107, 914]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,text,"The fixed negative charges on proteoglycans of the extracellular matrix are in the immediate vicinity of the chondrocyte and can attract cations (e.g., Na⁺), while also excluding anions. As a result, ","[602, 913, 1107, 1098]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,figure_title,"TABLE 1 | Ion concentrations in compartments within the mammalian knee joint (see Ref. Hall et al., 1996) (adapted from Table 1 in Wilkins et al., 2000a).","[604, 1149, 1095, 1188]",table_caption,0.9,"[""table prefix matched: TABLE 1 | Ion concentrations in compartments within the mamm""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,13,table,
Electrolyte concentrations (mM)CytoplasmMatrixSinovial fluid
$ [Na^{+}] $40240-350140
$ [K^{+}] $,"[604, 1199, 1103, 1431]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,14,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,15,number,3,"[588, 1483, 603, 1500]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,16,footer,September 2018 | Volume 9 | Article 974,"[854, 1481, 1103, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,header,Maleckar et al.,"[86, 56, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,text,"chondrocyte can serve as a significant diffusion barrier, as demonstrated recently with the use of optical trap methods (McLane et al., 2013). It is also important to note that the literature now sugg","[83, 123, 584, 281]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"The articular joint receives only very limited blood supply. Accordingly, the synovial fluid must supply adult articular cartilage with the required (small amounts of) nutrients, as well as sufficient","[83, 283, 586, 697]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,MODEL DEVELOPMENT,"[84, 719, 370, 746]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: MODEL DEVELOPMENT""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +4,5,text,"We have developed a new, first generation mathematical model for the resting membrane potential, $ E_m $, of the chondrocyte, based partly on the experimental data obtained and described in section E","[82, 765, 584, 1201]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"The equation governing the transmembrane potential, V, of the chondrocyte is","[83, 1201, 581, 1247]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,display_formula," $$ \begin{align*}C_m\frac{dV}{dt}=&-(I_{K-DR}+I_{K-Ca}+I_{K-2p}+I_{K-ATP}+I_{Na,b}+I_{K,b}\\&+I_{Cl,b}+I_{NaK}+I_{NaCa}+I_{TRPV4})\tag{1}.\end{align*} $$ ","[90, 1268, 576, 1341]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,8,text,"where $ C_m $ is chondrocyte capacitance (8 pF). This equation includes all transport processes that are electrogenic i.e., generate net transmembrane current(s). + +The intracellular concentrations of","[82, 1360, 584, 1431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,"The intracellular concentrations of Na+, [Na+]i and K+, +[K+]i, are governed by two transport equations, namely,","[604, 122, 1100, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,display_formula," $$ \frac{d[Na^{+}]_{i}}{dt}=\frac{-(I_{Na,b}+3I_{NaK}+3I_{NaCa}-I_{NaH})}{\nu o l_{i}F} $$ ","[670, 186, 1038, 236]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,11,formula_number,(2),"[1078, 201, 1102, 223]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +4,12,text,and,"[606, 253, 644, 275]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,short_fragment,False,True +4,13,display_formula," $$ \frac{d[K^{+}]_{i}}{dt}=\frac{-(I_{K,b}-2I_{NaK}+I_{K-DR}+I_{K-2p}+I_{K-Ca}+I_{K-ATP})}{\nu o l_{i}F} $$ ","[606, 288, 1103, 338]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,14,formula_number,(3),"[1077, 337, 1101, 358]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +4,15,text,"where $ vol_i $ is the internal volume of the chondrocyte (calculated to be 0.005884 mL), and $ F $ is the Faraday constant, 96,485 C/mol. Note that Equation (1) does not include $ I_{NaH} $, since","[602, 357, 1106, 747]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,16,text,"Intracellular Ca²⁺ concentration, [Ca²⁺]ᵢ, also changes with time, due to transmembrane transport of Ca²⁺ by the Na⁺-Ca²⁺ exchanger and ATP-dependent Ca²⁺ pump, and intracellular calmodulin binding, a","[603, 747, 1109, 840]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,17,display_formula," $$ \frac{d\left[Ca^{2+}\right]_{i}}{dt}=\frac{\left(I_{NaCa}-I_{Ca,ATP}\right)}{\nu o l_{i}F}-0.045\frac{d\mathbf{O}_{c}}{dt} $$ ","[675, 858, 1034, 911]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +4,18,formula_number,(4),"[1078, 876, 1102, 898]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +4,19,text,where $ O_c $ is the fraction of intracellular calmodulin bound to $ Ca^{2+} $ (see Equation 39).,"[605, 928, 1104, 973]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,20,text,"Differential equations (1–4) and those for $ I_{K,Ca} $ and calmodulin buffering were solved numerically. All data simulations and processing was performed off-line using both noncommercial and comme","[603, 973, 1107, 1159]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,21,paragraph_title,"RESULTS Ion-Selective Transmembrane Currents +Potassium Currents","[604, 1180, 1061, 1267]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: RESULTS Ion-Selective Transmembrane Currents\nPotassium Curre""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,22,footer,,"[604, 1217, 1061, 1267]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,23,text,"We have identified and partially characterized three different $ K^{+} $ currents in mammalian chondrocytes. In principle, each of these can contribute to the resting membrane potential, $ E_{m} $, ","[606, 1269, 1106, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,24,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,25,number,4,"[588, 1483, 602, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,26,footer,September 2018 | Volume 9 | Article 974,"[855, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,header,Maleckar et al.,"[86, 56, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,Chondrocyte K⁺ Currents Modulate E_m,"[858, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,image,,"[246, 130, 937, 626]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,"FIGURE 1 | Schematic illustration of the main ion selective channels, ion exchange proteins, and ATP-dependent ion pumps that are known to be expressed in human chondrocytes. This information forms th","[93, 649, 1092, 785]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 1 | Schematic illustration of the main ion selective ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +5,4,text,"K⁺ channels, I_K-2p; and (iii) a large conductance voltage and Ca²⁺-activated K⁺ current, I_K-Ca, have been studied in some detail in our laboratory (Wilson et al., 2004; Clark et al., 2010, 2011, res","[84, 832, 584, 1038]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,"A typical pattern of K⁺ currents from our patch clamp recordings using single isolated human articular chondrocytes (denoted HAC) is illustrated in Figure 2A. This chondrocyte first held at −80 mV, an","[83, 1040, 584, 1314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,"Figure 2B consists of an averaged isochronal current-voltage (I–V) relationship based on data obtained from 13 human chondrocytes, each studied after 1 day in cell culture. The magnitude of these $ K","[84, 1314, 584, 1431]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 2B consists of an averaged isochronal current-voltage""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +5,7,text,"in cell size. Note that this I–V relationship is approximately +linear at membrane potentials negative to about −50 mV but +becomes non-linear at more depolarized voltages. The solid red +trace shows the","[603, 833, 1106, 1109]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,paragraph_title,Delayed rectifier $ K^{+} $ current: $ I_{K-DR} $,"[605, 1131, 896, 1154]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Delayed rectifier $ K^{+} $ current: $ I_{K-DR} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +5,9,text,"A conventional time- and voltage-dependent delayed rectifier $ K^{+} $ current has been identified in mouse, canine, rabbit, and human articular chondrocytes under primary culture conditions (Wilson ","[605, 1153, 1105, 1384]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,The presence of this small time- and voltage-dependent current in these human chondrocyte (HAC) preparations was,"[604, 1384, 1107, 1431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,12,number,5,"[588, 1483, 603, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,13,footer,September 2018 | Volume 9 | Article 974,"[855, 1482, 1103, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,0,header,Maleckar et al.,"[86, 56, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,Chondrocyte K⁺ Currents Modulate E_m,"[858, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,2,chart,,"[217, 133, 615, 457]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,3,figure_title,B,"[636, 137, 652, 156]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,4,chart,,"[633, 154, 971, 484]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,figure_title,"FIGURE 2 | Family of K⁺ currents recorded from an isolated human chondrocyte maintained in primary 2D culture conditions. (A) These currents were recorded from a chondrocyte that was held at −80mV, an","[94, 509, 1093, 608]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 2 | Family of K\u207a currents recorded from an isolated h""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +6,6,text,revealed more clearly when the linear leak and capacity currents were removed from the raw current records (see Methods section). An example of current records from one HAC preparation in which these ,"[81, 658, 585, 1391]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,display_formula, $$ I_{K-D R}=g_{K-D R}\alpha_{K D r}(\mathrm{V}-\mathrm{E_{K}}) $$ ,"[208, 1407, 460, 1431]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +6,8,formula_number,(5),"[557, 1408, 581, 1429]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,9,text,where,"[606, 657, 661, 678]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,short_fragment,False,True +6,10,text,"gK–DR is the maximal $ I_{K–DR} $ conductance, namely 0.0289 nS/pF from Figure 3B, and","[603, 681, 1103, 726]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,text," $ \alpha_{KDr} $ is a voltage-dependent activation factor, given by the expression","[604, 727, 1105, 773]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,12,display_formula, $$ \alpha_{K D r}=\frac{1.0}{\left(1.0+e^{\frac{-(V+26.7)}{4.1}}\right)} $$ ,"[751, 787, 955, 841]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +6,13,formula_number,(6),"[1078, 800, 1102, 821]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,14,text,"Note that the extracellular potassium concentration, $ [K^+]_0 $, was initially set to 5.4 mM under “typical” physiological conditions. In fact, however, $ [K^+]_0 $ is likely to be in the 5–15 mM r","[603, 857, 1106, 1022]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,15,paragraph_title, $ Ca^{2+} $-activated $ K^{+} $ current: $ I_{K-Ca} $,"[606, 1037, 890, 1063]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: $ Ca^{2+} $-activated $ K^{+} $ current: $ I_{K-Ca} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +6,16,text,The prominent fluctuations in outward current traces recorded from all human chondrocytes at strongly depolarized membrane potentials suggested the expression of this “large” variant of Ca²⁺-activated,"[604, 1063, 1106, 1383]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,17,text,"To more clearly reveal the functionally important properties of this BK current, additional experiments were carried out","[604, 1385, 1106, 1431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,18,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 352, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,19,number,6,"[588, 1483, 602, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,20,footer,September 2018 | Volume 9 | Article 974,"[855, 1482, 1103, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,header,Maleckar et al.,"[86, 56, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,chart,,"[178, 134, 592, 523]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,3,figure_title,B,"[606, 138, 621, 156]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,4,chart,,"[602, 144, 1009, 533]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,5,figure_title,"FIGURE 3 | Delayed rectifier K⁺ currents, I_K–DR, in a human chondrocyte. (A) Examples of I_K–DR activated by voltage-clamp steps from holding potential of −80 mV to membrane potentials of −40, −30, −","[95, 561, 1094, 641]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 3 | Delayed rectifier K\u207a currents, I_K\u2013DR, in a human""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +7,6,text,"using a pipette solution containing 3 mM Ca²⁺ and 10 mM EGTA, which yielded a nominal free Ca²⁺ concentration of ~175 nM. Data from these experiments are summarized in Figure 4. Currents from two grou","[83, 696, 587, 1202]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"It is well-known that the molecular properties and biophysical characteristics of the extensive Ca²⁺ activated K⁺ channel family can be used to divide them into three sub-groups (Berkefeld et al., 201","[83, 1202, 585, 1410]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"strongly suggest the presence of the variant of Ca2+ activated K+ +channels known as the large conductance subtype, BK. The major +properties of this current (cf. Horrigan and Aldrich, 2002) have +been i","[603, 695, 1107, 809]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"The mathematical description for this $ Ca^{2+} $-activated $ K^{+} $current is a 10-state kinetic Markov-type model, including four calcium-binding steps, with all the voltage dependence assigned t","[604, 809, 1107, 926]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,display_formula, $$ \frac{d\mathbf{C}_{O}}{dt}=\beta_{O}\mathbf{O}_{o}-\alpha_{O}\mathbf{C}_{o}+K_{c}\mathbf{C}_{1}-4Ca\mathbf{C}_{o} $$ ,"[607, 938, 932, 986]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,11,formula_number,(7),"[1078, 952, 1102, 972]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,12,display_formula, $$ \frac{d\mathbf{C}_{1}}{dt}=\beta_{1}\mathbf{O}_{1}-\alpha_{1}\mathbf{C}_{1}-K_{c}\mathbf{C}_{1}+4Ca\mathbf{C}_{o}-3Ca\mathbf{C}_{1}+2K_{c}\mathbf{C}_{2} $$ ,"[610, 987, 1073, 1030]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,13,formula_number,(8),"[1079, 999, 1102, 1019]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,14,display_formula, $$ \frac{d\mathbf{C}_{2}}{dt}=\beta_{2}\mathbf{O}_{2}-\alpha_{2}\mathbf{C}_{2}-2K_{c}\mathbf{C}_{2}+3Ca\mathbf{C}_{1}-2Ca\mathbf{C}_{2}+3K_{c}\mathbf{C}_{3} $$ ,"[611, 1033, 1081, 1080]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,15,formula_number,(9),"[1078, 1079, 1102, 1100]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,16,display_formula, $$ \frac{d\mathbf{C}_{3}}{dt}=\beta_{3}\mathbf{O}_{3}-\alpha_{3}\mathbf{C}_{3}-3K_{c}\mathbf{C}_{3}+2Ca\mathbf{C}_{2}-Ca\mathbf{C}_{3}+4K_{c}\mathbf{C}_{4} $$ ,"[611, 1102, 1073, 1147]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,17,formula_number,(10),"[1069, 1149, 1101, 1170]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,18,display_formula, $$ \frac{d\mathbf{C}_{4}}{dt}=\beta_{4}\mathbf{O}_{4}-\alpha_{4}\mathbf{C}_{4}-4K_{c}\mathbf{C}_{4}+Ca\mathbf{C}_{3} $$ ,"[611, 1169, 927, 1218]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,19,formula_number,(11),"[1069, 1185, 1101, 1206]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,20,display_formula, $$ \frac{d\mathbf{O}_{0}}{dt}=-\beta_{0}\mathbf{O}_{0}+\alpha_{0}\mathbf{C}_{0}+K_{0}\mathbf{O}_{1}-4Ca\mathbf{O}_{0} $$ ,"[610, 1219, 945, 1264]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,21,formula_number,(12),"[1069, 1232, 1102, 1253]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,22,display_formula, $$ \frac{d\mathbf{O}_{1}}{dt}=-\beta_{1}\mathbf{O}_{1}+\alpha_{1}\mathbf{C}_{1}-K_{o}\mathbf{O}_{1}+4Ca\mathbf{O}_{o}-3Ca\mathbf{O}_{1}+2K_{o}\mathbf{O}_{2} $$ ,"[608, 1265, 1095, 1312]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,23,formula_number,(13),"[1069, 1314, 1102, 1335]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,24,display_formula, $$ \frac{d\mathbf{O}_{1}}{dt}=-\beta_{2}\mathbf{O}_{2}+\alpha_{2}\mathbf{C}_{2}-2K_{o}\mathbf{O}_{2}+3Ca\mathbf{O}_{1}-2Ca\mathbf{O}_{2}+2K_{o}\mathbf{O}_{3} $$ ,"[608, 1335, 1104, 1384]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,25,formula_number,(14),"[1069, 1386, 1102, 1407]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,26,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,27,number,7,"[588, 1483, 602, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,28,footer,September 2018 | Volume 9 | Article 974,"[855, 1481, 1104, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,0,header,Maleckar et al.,"[86, 57, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858, 56, 1103, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,2,figure_title,A,"[225, 136, 242, 155]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,3,image,,"[227, 135, 501, 382]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,4,chart,,"[533, 136, 955, 433]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,5,figure_title,B,"[226, 400, 241, 418]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,6,chart,,"[226, 407, 524, 622]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,7,figure_title,D,"[585, 446, 603, 464]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,8,chart,,"[581, 457, 965, 741]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,"FIGURE 4 | Effect of changes in intracellular Ca²⁺, [Ca²⁺], concentration on K⁺ currents in human articular chondrocytes. (A) ×example of currents from a hN₂ with ""low"" internal [Ca²⁺], (0 [Ca²⁺], 10 ","[92, 767, 1087, 885]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 4 | Effect of changes in intracellular Ca\u00b2\u207a, [Ca\u00b2\u207a], ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +8,10,display_formula, $$ \frac{d\mathbf{O}_{3}}{dt}=-\beta_{3}\mathbf{O}_{3}+\alpha_{3}\mathbf{C}_{3}-3K_{o}\mathbf{O}_{3}+2Ca\mathbf{O}_{2}-Ca\mathbf{O}_{3}+4K_{o}\mathbf{O}_{4} $$ ,"[88, 929, 574, 975]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,11,formula_number,(15),"[548, 978, 580, 998]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,12,display_formula, $$ \frac{d\mathbf{O}_{4}}{d t}=-\beta_{4}\mathbf{O}_{4}+\alpha_{4}\mathbf{C}_{4}-4K_{o}\mathbf{O}_{4}+C a\mathbf{O}_{3} $$ ,"[88, 1000, 425, 1048]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,13,formula_number,(16),"[549, 1014, 580, 1033]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,14,text,"where $ C_{n=0,1,2,3,4} $ and $ O_{n=0,1,2,3,4} $ are closed and open states 1 through 4, respectively, with the total open probability corresponding to the sum of the open states, $ O $; $ \alpha","[83, 1067, 584, 1250]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,display_formula, $$ \alpha_{n}=A_{n}e^{\frac{z_{CO}VF}{RT}} $$ ,"[257, 1269, 392, 1305]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,16,formula_number,(17),"[548, 1279, 580, 1300]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,17,display_formula, $$ \beta_{n}=B_{n}e^{\frac{z_{OC}VF}{RT}} $$ ,"[259, 1304, 392, 1339]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,18,formula_number,(18),"[548, 1314, 580, 1335]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,19,display_formula," $$ A_{0}=0.659,A_{1}=3.955,A_{2}=25.05,A_{3}=129.2,A_{4}=261.1; $$ ","[106, 1361, 578, 1385]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,20,display_formula," $$ B_{0}=2651.7,B_{1}=1767.8,B_{2}=1244.0,B_{3}=713.0,B_{4}=160.0; $$ ","[108, 1384, 583, 1408]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,21,display_formula," $$ z_{CO}=0.718,z_{OC}=0.646,K_{c}=13.5,K_{O}=1.5, $$ ","[108, 1410, 567, 1431]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,22,text,"and the Ca²⁺ on-rates per site are 10⁹ M⁻¹s⁻¹, Ca²⁺ off-rates from Cₙ per binding site are 10⁹ Kₑ (13,500 s⁻¹) and Ca²⁺ off-rates from Oₙ per binding site are 10⁹ Kₒ (1,500 s⁻¹), and R is the universa","[604, 931, 1105, 1049]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,23,text, $ I_{K-Ca} $ is then defined by:,"[629, 1050, 825, 1072]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,24,display_formula, $$ I_{K-Ca}=g_{K-Ca}\mathbf{O}(V-E_{K}) $$ ,"[744, 1102, 965, 1126]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,25,formula_number,(19),"[1069, 1102, 1101, 1123]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,26,text,"where $ g_{K-Ca} $ is the maximal conductance of the channel, equal to 2.50 nS/pF, O is the total open probability as given above, V is the transmembrane potential, and $ E_{K} $ is the Nernst poten","[604, 1155, 1105, 1245]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,27,text,We have used this mathematical formalism to compute I-V relationships for BK currents that can be assumed to have been recorded from isolated human chondrocytes under conditions in which the compositi,"[603, 1247, 1106, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,28,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1483, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,29,number,8,"[588, 1483, 602, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,30,footer,September 2018 | Volume 9 | Article 974,"[855, 1482, 1103, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,header,Maleckar et al.,"[86, 57, 180, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,2,text,"depolarized membrane potentials, as shown by the computations summarized in Figure 4D.","[83, 123, 583, 168]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,Further information regarding the functional properties of this BK channel-mediated current was obtained using conventional pharmacological approaches. As shown in Figure 5 this $ K^{+} $ current can,"[81, 169, 584, 353]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"Although, $ I_{K-Ca} $ is a major outward current in human chondrocytes, it apparently does not contribute substantially to the resting potential under our conditions. This is because of the followin","[82, 352, 586, 606]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,paragraph_title,2-Pore $ K^{+} $ current: $ I_{K-2p} $,"[606, 122, 819, 146]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2-Pore $ K^{+} $ current: $ I_{K-2p} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +9,6,text,"Our previous work (Clark et al., 2011) defined recording conditions under which a K⁺ current generated by the TASK family of two-pore K⁺ channels could be identified consistently in single chondrocyte","[602, 144, 1106, 395]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,text,"We have recorded this $ K^{+} $ current under high $ [K^{+}]_{0} $ conditions, to ensure that the current changes are relatively large, so that their biophysical properties can be resolved. However,","[603, 397, 1107, 606]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,figure_title,A,"[168, 662, 186, 682]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,9,image,,"[166, 661, 531, 800]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,10,figure_title,B,"[169, 825, 186, 843]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,11,image,,"[169, 821, 529, 920]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,12,chart,,"[554, 660, 1023, 975]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,13,figure_title,C,"[168, 978, 187, 998]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,14,chart,,"[165, 987, 550, 1288]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,15,figure_title,E,"[583, 986, 601, 1006]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +9,16,chart,,"[577, 1000, 1010, 1299]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,17,figure_title,FIGURE 5 | Block of $ I_{K-Ca} $ in human chondrocyte by TEA. (A) Control currents. The voltage-clamp protocol consisted of 500 ms steps from h.p. -80 to +100 mV. Linear leak and capacitive currents ,"[90, 1319, 1095, 1418]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 5 | Block of $ I_{K-Ca} $ in human chondrocyte by TE""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +9,18,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,19,number,9,"[588, 1483, 602, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,20,footer,September 2018 | Volume 9 | Article 974,"[855, 1481, 1104, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,0,header,Maleckar et al.,"[86, 57, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,2,text,"square root of the extracellular concentration of the permeant ion. Accordingly, $ I_{K-2p} $ is described by the classical Goldman-Hodgkin-Katz equation for a single ion species, with a square-root ","[83, 123, 584, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,display_formula, $$ I_{K-2p}=\frac{P_{k}z^{2}V F^{2}}{R T}\frac{\left(\left[K^{+}\right]_{i}-\left[K^{+}\right]_{o}e^{\frac{-z V F}{R T}}\right)}{\left(1-e^{\frac{-z V F}{R T}}\right)} $$ ,"[166, 237, 499, 313]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,4,formula_number,(20),"[547, 264, 578, 287]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,5,text,"where $ P_K $ is a $ [K^+] $-dependent scaling factor that describes the permeability (conductance) for this $ K^+ $ current, namely $ 3.1 \times 10^{-6} $ $ \sqrt{([K^+]_i / [K^+]_o)} $, and $ ","[82, 337, 582, 408]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"The I–V relationship in Figure 6A shows that our primary data (Wilson et al., 2004) recorded in isotonic $ [K^+] $ ( $ \sim $145 mM), has the expected reversal potential (of 0 mV). The I–V relationsh","[83, 408, 584, 570]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,chart,,"[109, 627, 566, 873]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,8,figure_title,Voltage (mV),"[323, 880, 421, 904]",figure_caption_candidate,0.85,"[""figure_title label: Voltage (mV)""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +10,9,figure_title,B,"[113, 922, 130, 942]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,10,chart,,"[127, 919, 560, 1180]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,11,figure_title,FIGURE 6 | Analysis of the ion transfer function (I–V relationship) for a 2-pore K⁺ current in human chondrocytes. (A) Raw experimental data plotted as an I–V curve together with a superimposed I–V re,"[91, 1206, 568, 1419]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 6 | Analysis of the ion transfer function (I\u2013V relati""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +10,12,text,"As illustrated in Table 1, the extracellular milieu of the chondrocyte is somewhat unusual, since it has been reported to have a $ [K^+]_{o} $ level of $ \sim $7–12 mM. Accordingly, a I–V curve for ","[603, 122, 1107, 377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,13,paragraph_title,ATP-sensitive $ K^{+} $ current: $ I_{K-ATP} $,"[605, 402, 888, 425]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: ATP-sensitive $ K^{+} $ current: $ I_{K-ATP} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +10,14,text,"An ATP-sensitive K⁺ current I_K-ATP has been identified in chondrocytes that were isolated from the knee joint of a number of different mammalian species (Barrett-Jolley et al., 2010; Mobasheri et al.","[601, 425, 1107, 864]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,15,display_formula," $$ I_{K-,A T P}=\sigma g_{o}p_{o}f_{A T P}(\mathbf{V}-\mathbf{E_{K}}) $$ ","[722, 891, 972, 916]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,16,formula_number,(21),"[1068, 892, 1102, 914]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,17,text,"where $ \sigma = 0.6 $ is the channel density, $ g_o $ is the unitary channel conductance, $ p_o = 0.91 $ is the maximum open channel probability, and $ f_{ATP} $ is the fraction of activated chan","[603, 944, 1106, 1037]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,18,display_formula, $$ f_{ATP}=\frac{1.0}{1.0+\left[\frac{ATP_{i}}{K_{m}}\right]^{H}} $$ ,"[739, 1062, 926, 1129]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,19,formula_number,(22),"[1069, 1075, 1102, 1096]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,20,formula_number,(23),"[1069, 1136, 1101, 1157]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,21,display_formula, $$ H=1.3+0.74e^{-H_{K_{A T P}}A D P_{i}} $$ ,"[758, 1132, 981, 1159]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,22,display_formula," $$ K_{m}=35.8+17.9ADP_{i}^{K_{m,ATP}} $$ ","[748, 1161, 982, 1188]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,23,formula_number,(24),"[1069, 1165, 1101, 1186]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,24,display_formula, $$ \mathrm{ADP_{i}~=~C_{A}-ATP_{i}} $$ ,"[727, 1193, 905, 1218]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +10,25,formula_number,(25),"[1069, 1194, 1101, 1215]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,26,text,"where $ C_A = 8 \, mM $ is the total concentration of adenine nucleotides, $ ADP_i $ and $ ATP_i $ are the intracellular concentrations of adenosine diphosphate, (ADP) and adenosine triphosphate, (","[603, 1246, 1104, 1339]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,27,text,"Note that this ATP-sensitive K⁺ current is not utilized in our initial description of the ionic basis for the HAC resting potential. That is, its channel density, σ, has been set to zero in our initia","[603, 1339, 1105, 1431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,28,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,29,number,10,"[586, 1483, 606, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,30,footer,September 2018 | Volume 9 | Article 974,"[855, 1481, 1103, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,header,Maleckar et al.,"[86, 57, 180, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1104, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,2,paragraph_title,Time-Independent or Background Ionic Currents,"[84, 122, 540, 145]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Time-Independent or Background Ionic Currents""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +11,3,text,"Three distinct time-independent background (or leakage) conductances corresponding to “resting” Na⁺, K⁺, and Cl⁻ fluxes, have been included in this model. Simple mathematical descriptors for each cond","[84, 147, 583, 259]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"The background (inward) $ Na^{+} $ and (outward) $ K^{+} $ currents, are described by.","[84, 259, 583, 307]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,display_formula," $$ I_{Na,b}\;=\;G_{Na,b}(\mathrm{V}-\mathrm{E_{Na}}) $$ ","[226, 328, 426, 352]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,6,formula_number,(26),"[547, 329, 580, 350]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,7,display_formula," $$ I_{K,b}=G_{K,b}(\mathbf{V}-\mathbf{E_{K}}) $$ ","[245, 357, 426, 381]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,8,formula_number,(27),"[548, 358, 580, 379]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,9,text,"where $ G_{Na,b} = 0.1 $ nS/pF is the maximum conductance for the background sodium channel, and $ G_{K,b} = 0.07 $ nS/pF is the maximum conductance for the background potassium channel. $ [Na^+]_o","[82, 401, 584, 700]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,text,"In mammalian chondrocytes from a number of different species, a significant background $ Cl^{-} $conductance has also been identified (cf. Tsuga et al., 2002; Barrett-Jolley et al., 2010; Funabashi e","[83, 701, 584, 840]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,display_formula," $$ I_{Cl,b}\;=\;{\bf G}_{Cl,b}(V-E_{Cl}) $$ ","[241, 860, 428, 885]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,12,formula_number,(28),"[547, 861, 581, 882]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,13,text,"where $ G_{Cl,b} = 0.05 $ pS/pF is the maximum conductance for the background $ Cl^{-} $ channel, and where the reversal potential, is -65 mV. The I-V relationships for these three background curren","[82, 904, 584, 998]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,14,paragraph_title,Ion Pump and Exchanger Currents Electrogenic Na $ ^{+} $/K $ ^{+} $ pump: I $ _{NaK} $,"[84, 1012, 410, 1061]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Ion Pump and Exchanger Currents Electrogenic Na $ ^{+} $/K $""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +11,15,footer,,"[85, 1038, 365, 1061]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +11,16,text,Active (ATP requiring) extrusion of Na⁺ from chondrocytes is assumed to be achieved by the combined expression level and turnover rate of a conventional electrogenic Na⁺/K⁺ pump. Mobasheri et al. (199,"[84, 1061, 583, 1225]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,17,display_formula, $$ \begin{aligned}I_{NaK}&=\overline{I}_{NaK}\left(\frac{\left[K^{+}\right]_{o}}{\left[K^{+}\right]_{o}+k_{NaK_{K}}}\right)\left(\frac{\left[Na^{+}\right]_{i}^{1.5}}{\left[Na^{+}\right]_{i}^{1.5}+k_{,"[114, 1241, 548, 1359]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,18,formula_number,(29),"[547, 1326, 581, 1347]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,19,text,where $\bar{I}_{NaK}$ is the maximal current density $1.58\ \mathrm{pA/pF}\ \left[\mathrm{K}^{+}\right]_{0}$ is the extracellular potassium concentration. It has been initially set to $140\ \mathrm{mM,"[82, 1382, 582, 1431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,20,text,"set to 140 mM for “typical” values; Table 1), [Na+]i is the +intracellular sodium concentration, as defined previously, and +given by equation (2), kNaK,K is the half-maximum K+ binding +concentration, an","[604, 122, 1105, 235]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,21,text,"This Na⁺/K⁺ pump activity (the product of expression density and turnover rate) generates a small outward electrogenic current. In this simplified model (cf. Trujillo et al., 1999) this Na⁺/K⁺ pump ma","[603, 236, 1106, 378]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,22,display_formula, $$ Na^{+}/Ca^{2}+Exchanger:I_{NaCa} $$ ,"[606, 390, 847, 415]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,23,text,"The activity of the Na⁺/Ca²⁺ exchanger plays a key role in Ca²⁺ homeostasis in articular chondrocytes (Sánchez et al., 2006) as it does in most other cell types. We have modeled this electrogenic exch","[603, 413, 1105, 532]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,24,chart,,"[615, 588, 1092, 869]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,25,vision_footnote,"Na_i = 8.5mM, Na_o = 130mM, Ca_i = 5e-5mM, Ca_o = 2mM","[649, 923, 1094, 943]",footnote,0.7,"[""vision_footnote label: Na_i = 8.5mM, Na_o = 130mM, Ca_i = 5e-5mM, Ca_o = 2mM""]",footnote,0.7,body_zone,unknown_like,none,True,True +11,26,figure_title,B,"[624, 948, 643, 966]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,27,image,,"[627, 959, 1076, 1223]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,28,figure_title,"FIGURE 7 | Illustrations of the relative sizes of net currents produced by (A) the Na⁺/K⁺ pump, and (B) the Na⁺/Ca²⁺ exchanger in a human chondrocyte. The three superimposed I–V curves for the Na⁺/K⁺ ","[613, 1242, 1091, 1418]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 7 | Illustrations of the relative sizes of net curren""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +11,29,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1502]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,30,number,11,"[585, 1483, 605, 1500]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,31,footer,September 2018 | Volume 9 | Article 974,"[855, 1482, 1104, 1500]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,0,header,Maleckar et al.,"[86, 57, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,2,text,"properties (ion transfer characteristics, dependence on $ [Na^{+}]_{i} $ and $ [Ca^{2+}]_{i} $ have been validated previously (Nygren et al., 1998):","[83, 122, 582, 170]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,display_formula, $$ I_{NaCa}=k_{NaCa}\frac{\left[Na^{+}\right]_{i}^{3}\left[Ca^{2+}\right]_{o}e^{\frac{\gamma VF}{RT}}-\left[Na^{+}\right]_{o}^{3}\left[Ca^{2+}\right]_{i}e^{\frac{(\gamma-1.0)VF}{RT}}}{1.0+d_{NaCa}\le,"[88, 193, 575, 262]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,4,formula_number,(30),"[548, 259, 581, 280]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,5,text,"Where $ k_{NaCa} $ is a scaling factor for this current, set to 0.0374842 pA/(mmol/L) $ ^4 $, $ \gamma $ is the position of the energy barrier that modulates the voltage dependence of $ I_{NaCa} $,","[83, 279, 584, 508]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,text,"This electrogenic ion exchange mechanism has been scaled based on a baseline or resting $ [\mathrm{Na}^{+}]_{\mathrm{i}} $ of 12 mM, and $ [\mathrm{Ca}^{2+}]_{\mathrm{i}} $ of 3 x 10 $ ^{-8} $ M (se","[83, 511, 580, 605]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,paragraph_title, $ Na^{+}/H^{+} $ exchanger: $ I_{NaH} $,"[86, 623, 296, 648]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: $ Na^{+}/H^{+} $ exchanger: $ I_{NaH} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +12,8,text,"Chondrocytes express a Na⁺/H⁺ antiporter (Trujillo et al., 1999; Barrett-Jolley et al., 2010) that contributes importantly to pH regulation. By analogy with its role in many other cells and tissues, t","[84, 647, 583, 899]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,We have used the equations originally developed by Crampin and Smith (2006) to model this electroneutral antiporter:,"[83, 900, 583, 946]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,10,display_formula, $$ I_{NaH}=N_{NaH}I_{NaH_{mod}}I_{NaH_{exch}} $$ ,"[230, 973, 458, 1000]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,11,formula_number,(31),"[548, 974, 580, 995]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,12,display_formula, $$ I_{NaHmod}=\frac{1}{1+(K_{i}^{n_{H}}/\left[H^{+}\right]_{i}^{n_{H}}} $$ ,"[205, 1013, 453, 1064]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,13,formula_number,(32),"[548, 1023, 580, 1044]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,14,display_formula, $$ I_{NaH_{exch}}=\frac{t_{1}t_{2}-t_{3}t_{4}}{t_{1}+t_{2}+t_{3}+t_{4}} $$ ,"[210, 1076, 434, 1126]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,15,formula_number,(33),"[548, 1088, 580, 1109]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,16,display_formula, $$ t_{1}=\frac{k_{1}^{+}\left[Na^{+}\right]_{o}/K_{Na}^{o}}{1+\frac{\left[Na^{+}\right]_{o}}{K_{Na}^{o}}+\frac{\left[H^{+}\right]_{o}}{K_{H}^{o}}} $$ ,"[252, 1144, 460, 1219]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,17,formula_number,(34),"[548, 1165, 580, 1186]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,18,display_formula, $$ t_{2}=\frac{k_{2}^{+}\left[H^{+}\right]_{i}/K_{H}^{i}}{1+\frac{\left[Na^{+}\right]_{i}}{K_{Na}^{i}}+\frac{\left[H^{+}\right]_{i}}{K_{H}^{i}}} $$ ,"[252, 1240, 456, 1316]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,19,formula_number,(35),"[548, 1261, 580, 1282]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,20,display_formula, $$ t_{3}=\frac{k_{1}^{-}\left[Na^{+}\right]_{i}/K_{Na}^{i}}{1+\frac{\left[Na^{+}\right]_{i}}{K_{Na}^{i}}+\frac{\left[H^{+}\right]_{i}}{K_{H}^{i}}} $$ ,"[252, 1339, 455, 1412]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,21,formula_number,(36),"[547, 1359, 580, 1380]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,22,display_formula, $$ t_{4}=\frac{k_{2}^{-}\left[H^{+}\right]_{o}/K_{H}^{o}}{1+\frac{\left[Na^{+}\right]_{o}}{K_{Na}^{o}}+\frac{\left[H^{+}\right]_{o}}{K_{H}^{o}}} $$ ,"[772, 116, 980, 188]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,23,formula_number,(37),"[1069, 134, 1102, 157]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,24,text,"where, $ N_{NaH} = 4899 $, $ k_1^+ $ = 10.5, $ k_1^- $ = 0.201, $ k_2^+ $ = 15.8, $ k_2^- $ = 183, $ k_H^{i} $ = 3.07e-5, $ k_H^{i} $ = 4.8e-7, $ k_Na^+ $ = 16.2, $ k_Na^- $ = 195, $ k_H^+ $","[606, 231, 1105, 442]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,25,paragraph_title,"Intracellular $ [Ca^{2+}]_{i} $ Homeostasis: ATP-Dependent Ca Pump: $ I_{Ca,ATP} $","[604, 456, 1104, 504]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intracellular $ [Ca^{2+}]_{i} $ Homeostasis: ATP-Dependent ""]",subsection_heading,0.6,body_zone,body_like,none,True,True +12,26,text,"In human chondrocytes, $ [Ca^{2+}]_i $ is regulated by a combination of ion transporters, ion pumps, and intrinsic intracellular $ Ca^{2+} $ buffering mechanisms. As noted, there is evidence that $","[602, 505, 1105, 710]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,27,text,The $ Ca^{2+} $ pump ion transporter is electroneutral as a consequence of its ability to allow two $ H^{+} $ ions to move into the cell for each $ Ca^{2+} $ ion that is extruded per transport cycl,"[602, 711, 1106, 941]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,28,display_formula," $$ I_{Ca,ATP}=Imax_{Ca,ATP}\frac{[Ca^{2+}]_{i}}{[Ca^{2+}]_{i}+k_{Ca,ATP}} $$ ","[696, 959, 1011, 1015]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,29,formula_number,(38),"[1069, 976, 1101, 997]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,30,text,and,"[607, 1031, 643, 1053]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,short_fragment,False,True +12,31,display_formula, $$ \frac{d\mathbf{O}_{C}}{d t}=2x10^{5}[C a^{2+}]_{i}\left(1-\mathbf{O}_{C}\right)-476\mathbf{O}_{C} $$ ,"[693, 1065, 1019, 1108]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +12,32,formula_number,(39),"[1069, 1077, 1102, 1098]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,33,text,"where $ I_{\text{max}} = 0.6349 \, \text{pA/pF} $ is the maximal $ Ca^{2+} $ pump current density, $ k_{Ca,ATP} $ is the half-maximum $ Ca^{2+} $ binding concentration, $ (0.0002 \, \text{mmol/L}","[605, 1122, 1104, 1239]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,34,paragraph_title,Transient Receptor Potential (TRP) Current: $ I_{TRPV4} $,"[606, 1255, 1071, 1278]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Transient Receptor Potential (TRP) Current: $ I_{TRPV4} $""]",subsection_heading,0.6,body_zone,body_like,none,True,True +12,35,text,"A fundamental question concerning the electrophysiology of non-excitable cells is: how do they sense the external environment and what ion flux mechanism(s) are responsible for this ""trigger/transduce","[604, 1278, 1106, 1418]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,36,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,37,number,12,"[586, 1483, 606, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,38,footer,September 2018 | Volume 9 | Article 974,"[855, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,0,header,Maleckar et al.,"[86, 56, 180, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,2,text,"of ion channels (Nilius and Oswianik, 2011; Kaneko and Szallasi, 2014) are expressed in mammalian chondrocytes (cf. Gavenis et al., 2009; Phan et al., 2009; Clark et al., 2010; Asmar et al., 2016). Sp","[82, 123, 584, 511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,text,We have identified significant TRP currents in human articular chondrocyte (HAC) preparations after superfusion with novel “TRPV4 activator” compounds synthesized by Glaxo Smith Kline (GSK) (Thorneloe,"[82, 512, 585, 652]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"and a variety of other published results we have formulated +the working hypothesis that, in the human chondrocyte, there +is a multicomponent signaling complex that includes: TRP +channels, Ca2+-activat","[602, 122, 1107, 375]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,paragraph_title,GSK SB488-induced currents in voltage-clamped human chondrocytes,"[603, 399, 1068, 446]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: GSK SB488-induced currents in voltage-clamped human chondroc""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +13,6,text,"The GSK compound SB488 is a potent agonist for TRPV4 channels (Nilius and Oswianik, 2011; Hilfiker et al., 2013). Our preliminary work has shown that SB488 (1 μM) can induce large non-selective cation","[602, 446, 1106, 655]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,chart,,"[174, 692, 589, 1026]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,8,figure_title,B,"[178, 1012, 196, 1030]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +13,9,chart,,"[175, 1036, 591, 1298]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,10,chart,,"[618, 718, 1023, 1202]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,11,paragraph_title,FIGURE 8,"[96, 1321, 172, 1340]",figure_caption,0.9,"[""figure prefix matched: FIGURE 8""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +13,12,figure_title,"FIGURE 8 | Activation of TRPV4 channel currents by the GSK agonist, SB488, in human articular chondrocytes. (A) Time course of membrane current density changes at +100 (open circles) and −100 mV (clos","[90, 1319, 1089, 1419]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 8 | Activation of TRPV4 channel currents by the GSK a""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +13,13,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,14,number,13,"[585, 1483, 607, 1500]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,15,footer,September 2018 | Volume 9 | Article 974,"[855, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,0,header,Maleckar et al.,"[86, 56, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,2,chart,,"[149, 141, 574, 592]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,3,chart,,"[603, 166, 1048, 582]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,4,figure_title,FIGURE 9 | Block of SB488-induced currents through TRPV4 channels by SB779. (A) Time course of membrane current changes at +100 (open circles) and −100 mV (closed circles) during repeated ramp voltage,"[95, 616, 1095, 697]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 9 | Block of SB488-induced currents through TRPV4 cha""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +14,5,text,preparations. Figure 8 shows a representative example of the time course and I-V relationships of the SB488-induced currents in a voltage-clamped HAC. Figure 8A consists of a plot of these membrane cu,"[83, 735, 584, 941]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,Examples of HAC I-V relations recorded before and during SB488 application are shown in Figure 8B. The baseline or control current was very small and its I–V was essentially linear over the entire pot,"[83, 942, 585, 1220]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,text,"A different GSK compound, SB779, (Hilfiker et al., 2013) can potently block the currents induced by SB488. It was also studied in our HAC preparations. The data in Figure 9 confirm that SB 799 is an e","[82, 1220, 585, 1429]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,8,text,"current was quickly blocked by application of SB779 (even in +the presence of SB488). This marked reduction of the SB488- +induced current by SB779 is consistent with either block of a +SB488 “receptor,”","[603, 735, 1106, 967]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,9,paragraph_title,DISCUSSION The Resting Membrane Potential in Human Chondrocytes,"[604, 995, 1103, 1086]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: DISCUSSION The Resting Membrane Potential in Human Chondrocy""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +14,10,footer,,"[604, 1033, 1103, 1086]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +14,11,text,The new electrophysiological data and first order mathematical model provided by this study add significantly to the previously published papers on fundamental mechanisms of human chondrocyte biology ,"[602, 1091, 1106, 1431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,12,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,13,number,14,"[585, 1483, 606, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,14,footer,September 2018 | Volume 9 | Article 974,"[854, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,0,header,Maleckar et al.,"[86, 57, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[857, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,2,text,"alterations in $ E_{m} $ can contribute to dynamic regulation of cell volume (Barrett-Jolley et al., 2010; Lewis et al., 2011).","[83, 123, 584, 168]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,3,text,"Given the technical difficulty of making accurate, reproducible recordings of transmembrane ionic currents in small cells that have large input resistances, our mathematical model provides an addition","[83, 169, 585, 467]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,4,text,"At this stage of model development our simulations do not fully reveal the ionic basis for $ E_m $ in isolated human chondrocytes. However, they provide further insight into the consistent finding th","[83, 468, 585, 857]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,5,paragraph_title,The Physiological Milieu of the Chondrocyte,"[84, 892, 440, 947]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: The Physiological Milieu of the Chondrocyte""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +15,6,text,"Classical knowledge of unusual physiologic milieu (see Table 1) within the articular joint yields the expectation that these conditions would be expected to regulate the $ E_m $, e.g., by altering th","[83, 949, 584, 1201]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,7,text,We were very interested in an additional mechanism through which changes in the osmolarity of the superfusate or extracellular solution may manifest themselves. It is well-known that changes in osmola,"[83, 1200, 584, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,8,text,"known that divalent or trivalent cations, (as well as charged +osmolytes) can effectively reduce the zeta potential component +of the overall membrane potential (Hille, 2001). Although +surface potential ","[603, 123, 1107, 536]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,9,text,Perhaps the strongest evidence that in situ the chondrocyte can exhibit significant surface membrane delimited zeta potentials (and restricted diffusion profiles) has been provided by both classical a,"[603, 537, 1106, 925]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,10,text,"As noted in the Introduction, the pH in the extracellular matrix can be somewhat acidic, ~6.9 as opposed to 7.2 (see Table 1). Changes in $ [H^+]_0 $ measured in terms of pH alteration can also have ","[603, 926, 1105, 1109]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,11,text,"Other conditions that characterize the milieu mammalian articular chondrocyte would also be expected to have very significant electrophysiological consequences, mainly by altering $ E_m $. Perhaps th","[602, 1110, 1106, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,12,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,13,number,15,"[585, 1483, 606, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,14,footer,September 2018 | Volume 9 | Article 974,"[854, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,0,header,Maleckar et al.,"[86, 56, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,2,chart,,"[103, 129, 552, 1140]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,3,figure_title,"FIGURE 10 | Demonstration of the effects of in silico changes in the voltage-dependence for activation of the delayed rectifier K⁺ current, I_K–DR Panels (A,B), illustrate the altered activation curve","[92, 1167, 572, 1416]",figure_caption,0.95,"[""Frontiers figure title pattern: FIGURE 10 | Demonstration of the effects of in silico change""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True +16,4,text,by the black traces in Figure 10C. Note that when $ [Na^+]_{i} $ is increased (8.6 to 15 mM) the extra outward $ Na^+/K^+ $ pump current can significantly hyperpolarize the chondrocyte $ E_m $. Aft,"[604, 123, 1106, 377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,5,text,"Ca²⁺-Influx and Ca²⁺-Dependent Currents +As noted, activation of TRPV4 channels would be expected to result in a significant influx of Ca²⁺ and Na⁺, and a related depolarization, when the chondrocyte m","[598, 396, 1107, 1066]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,paragraph_title,Connexin-Mediated Current Flow and Electrotonic Interactions,"[605, 1076, 1041, 1129]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Connexin-Mediated Current Flow and Electrotonic Interactions""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +16,7,text,"As mentioned in the Introduction, chondrocytes in articular joints from adult humans function as isolated, single cells. Interestingly, however, Cell Physiological data from early adolescent articular","[604, 1131, 1106, 1361]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,8,text,"We also note that is Cx43 increased expression in isolated adult chondrocytes can result in release ATP in response to e.g. mechanical perturbations (Millward-Sadler et al., 2004; Knight","[604, 1361, 1105, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,9,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,10,number,16,"[586, 1483, 606, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,11,footer,September 2018 | Volume 9 | Article 974,"[855, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,0,header,Maleckar et al.,"[86, 56, 179, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858, 56, 1103, 77]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,2,text,"et al., 2009; Garcia and Knight, 2010). One plausible mechanism for this, is the occurrence of transient openings of these “hemichannels” that consist of either pannexin or connexin subunits (Saez et ","[83, 122, 584, 513]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,3,paragraph_title,Limitations of the Mathematical Model of the Human Chondrocyte Resting Membrane Potential,"[84, 528, 561, 611]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Limitations of the Mathematical Model of the Human Chondrocy""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +17,4,text,"The mathematical model that we have developed is an important advance. However, we recognize that it has significant limitations. These include:","[83, 612, 584, 682]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,5,text,"a) It is apparent that Ca²⁺ is an essential signaling molecule in the chondrocyte. Expression of L-type Ca²⁺ channels has been reported in growth plate chondrocytes (Sugimoto et al., 1996; Zuscik et a","[82, 691, 584, 1012]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,6,text,"b) Mathematical expressions that would allow simulations of what has been termed “the AM and FM modes of Ca²⁺ signaling” (Berridge, 1997; Berridge et al., 2000), will require consideration of $ [Ca^{","[82, 1014, 583, 1197]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,text,"c) There is evidence that cell culture conditions can alter both chondrocyte phenotype and gene expression profiles (Spitzer et al., 2000; Chen et al., 2012; but see Asmar et al., 2016). These pattern","[84, 1197, 585, 1428]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,8,paragraph_title,SUMMARY,"[605, 118, 740, 145]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: SUMMARY""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +17,9,text,This mathematical model of chondrocyte electrophysiology provides a reliable platform for integrating and evaluating both recent and well-established experimental data that is relevant to the generati,"[602, 163, 1107, 741]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,10,paragraph_title,AUTHOR CONTRIBUTIONS,"[604, 762, 924, 789]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: AUTHOR CONTRIBUTIONS""]",section_heading,0.6,body_zone,support_like,none,True,True +17,11,text,"RBC carried out all of the experimental work in this paper, and provided valuable input into the development and validation of the mathematical model. MM when supervising Dr. H. Narayanan at Simula Re","[603, 806, 1107, 1064]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,12,paragraph_title,ACKNOWLEDGMENTS,"[604, 1084, 876, 1110]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +17,13,text,"An Alberta Innovates—Health Solutions (AI-HS) Scientist Award (WRG), an AI-HS Starter Grant, and a Canadian Institutes of Health Research Grant were combined to support this experimental work and rela","[602, 1131, 1107, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,14,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1482, 353, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,15,number,17,"[585, 1483, 606, 1499]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,16,footer,September 2018 | Volume 9 | Article 974,"[854, 1481, 1104, 1501]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +18,0,header,Maleckar et al.,"[86, 57, 179, 75]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858, 56, 1103, 76]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +18,2,text,"aspects of the computational work in this paper. Glaxo Smith Kline Laboratories in Philadelphia, Pennsylvania supplied the human chondrocyte cell line and TRPV4 agonists/antagonists that were used to ","[84, 123, 584, 232]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,3,paragraph_title,REFERENCES,"[86, 292, 254, 317]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +18,4,paragraph_title,SUPPLEMENTARY MATERIAL,"[605, 118, 951, 145]",backmatter_heading,0.5,"[""backmatter boundary candidate: SUPPLEMENTARY MATERIAL""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +18,5,text,The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphys.2018.00974/full#supplementary-material,"[603, 164, 1104, 234]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,6,reference_content,"Amanatullah, D. 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Differential regulation of action potentials by inactivating and nonactivating BK channels in rat adrenal chromaffin cells.","[608, 753, 1102, 824]",reference_item,0.85,"[""reference content label: Sun, L., Xiong, Y., Zeng, X., Wu, Y., Pan, N., Lingle, C. J.""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,32,reference_content,"Thorneloe, K. S., Sulpizio, A. C., and Westfall, T. D. (2008). N-((1S)-1-[[4-((2S)-2-[[2,4-Dichlorophenyl)sulfonyl]amino]-3-hydroxypropanoyl)-1-piperazinyl]carbonyl]-3-methylbutyl)-1-benzothiophene-2-","[608, 827, 1102, 940]",reference_item,0.85,"[""reference content label: Thorneloe, K. S., Sulpizio, A. C., and Westfall, T. D. (2008""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,33,reference_content,"Trujillo, E., Alvarez de la Rosa, D., Mobasheri, A., Gonzalez, T., Canessa, C. M., and Martin-Vasallo, P. (1999). Sodium transport systems in human chondrocytes II. 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C., and Gehl, K. A. (1993). Regulatio""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,36,reference_content,"Webb, S. T., and Ghosh, S. (2009). Intra-articular bupivacaine: potentially chondrotoxic? Br. J. Anaes. 102, 439–441. doi: 10.1093/bja/aep036","[608, 1168, 1103, 1205]",reference_item,0.85,"[""reference content label: Webb, S. T., and Ghosh, S. (2009). Intra-articular bupivacai""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,37,reference_content,"Wilkins, R. J., Browning, J. A., and Ellory, J. C. (2000a). Surviving in a matrix: membrane transport in articular chondrocytes. J. Membr. Biol. 177, 95–108. doi: 10.1007/s002320001103","[609, 1207, 1103, 1261]",reference_item,0.85,"[""reference content label: Wilkins, R. J., Browning, J. A., and Ellory, J. C. (2000a). ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,38,reference_content,"Wilkins, R. J., Browning, J. A., and Urban, J. P. (2000b). Chondrocyte regulation by mechanical load. Biorheology 37, 67–74.","[608, 1263, 1103, 1300]",reference_item,0.85,"[""reference content label: Wilkins, R. J., Browning, J. A., and Urban, J. P. (2000b). C""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,39,reference_content,"Wilson, J. R., Clark, R. B., Banderali, U., and Giles, W. R. (2011). Measurement of the membrane potential in small cells using patch clamp methods. Channels 5, 530–537. doi: 10.4161/chan.5.6.17484","[609, 1302, 1105, 1355]",reference_item,0.85,"[""reference content label: Wilson, J. R., Clark, R. B., Banderali, U., and Giles, W. R.""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,40,reference_content,"Wilson, J. R., Duncan, N. A., Giles, W. R., and Clark, R. B. (2004). A voltage-dependent K $ ^{+} $ current contributes to membrane potential of","[608, 1358, 1105, 1395]",reference_item,0.85,"[""reference content label: Wilson, J. R., Duncan, N. A., Giles, W. R., and Clark, R. B.""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,41,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1483, 352, 1501]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,42,number,20,"[585, 1484, 606, 1498]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,43,footer,September 2018 | Volume 9 | Article 974,"[855, 1482, 1103, 1500]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,0,header,Maleckar et al.,"[86, 58, 179, 75]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +21,1,header,Chondrocyte K⁺ Currents Modulate Eᵐ,"[858, 57, 1102, 76]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +21,2,reference_content,"acutely isolated canine articular chondrocytes. J. Physiol. 557, 93–104. doi: 10.1113/jphysiol.2003.058883","[106, 127, 581, 162]",reference_item,0.85,"[""reference content label: acutely isolated canine articular chondrocytes. J. Physiol. ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,3,reference_content,"Wilusz, R. E., Sanchez-Adams, J., and Guilak, F. (2014). The structure and function of the pericellular matrix of articular cartilage. Matrix Biol. 39, 25–32. doi: 10.1016/j.matbio.2014.08.009","[89, 164, 582, 219]",reference_item,0.85,"[""reference content label: Wilusz, R. E., Sanchez-Adams, J., and Guilak, F. (2014). The""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,4,reference_content,"Wright, M. O., Nishida, K., Bavington, C., Godolphin, J. L., Dunne, E., Walmsley, S., et al. (1997). Hyperpolarisation of cultured human chondrocytes following cyclical pressure-induced strain: eviden","[89, 222, 582, 331]",reference_item,0.85,"[""reference content label: Wright, M. O., Nishida, K., Bavington, C., Godolphin, J. L.,""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,5,reference_content,"Wu, Q. Q., and Chen, Q. (2000). Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Exp. Cell Res. 256, 383–3","[89, 336, 582, 408]",reference_item,0.85,"[""reference content label: Wu, Q. Q., and Chen, Q. (2000). Mechanoregulation of chondro""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,6,reference_content,"Zuscik, M. J., Gunter, T. E., Puzas, J. E., Rosier, R. N. (1997). Characterization of voltage-sensitive calcium channels in growth plate chondrocytes. Biochem. Biophys. Res. Commun. 234, 432–438. doi:","[607, 128, 1102, 182]",reference_item,0.85,"[""reference content label: Zuscik, M. J., Gunter, T. E., Puzas, J. E., Rosier, R. N. (1""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +21,7,reference_content,Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of inter,"[606, 202, 1103, 259]",reference_item,0.85,"[""reference content label: Conflict of Interest Statement: The authors declare that the""]",reference_item,0.85,reference_zone,support_like,none,True,True +21,8,reference_content,"Copyright © 2018 Maleckar, Clark, Votta and Giles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction","[605, 278, 1105, 408]",reference_item,0.85,"[""reference content label: Copyright \u00a9 2018 Maleckar, Clark, Votta and Giles. This is a""]",reference_item,0.85,reference_zone,support_like,none,True,True +21,9,footer,Frontiers in Physiology | www.frontiersin.org,"[86, 1483, 352, 1501]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +21,10,number,21,"[584, 1483, 605, 1499]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +21,11,footer,September 2018 | Volume 9 | Article 974,"[855, 1482, 1103, 1500]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/4DU8LEH2/block_trace.csv b/tests/fixtures/ocr_real_papers/4DU8LEH2/block_trace.csv new file mode 100644 index 00000000..5f916df1 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/4DU8LEH2/block_trace.csv @@ -0,0 +1,179 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,aside_text,Open Access,"[49, 139, 72, 238]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,short_fragment,False,True +1,1,aside_text,Orthopaedic Surgery,"[5, 1089, 53, 1495]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,short_fragment,False,True +1,2,header_image,,"[4, 59, 72, 133]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,3,header,1997,"[565, 50, 627, 79]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,text,"© 2022 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.","[228, 97, 962, 120]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2022 The Authors. Orthopaedic Surgery published by Tianjin""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,5,text,CLINICAL ARTICLE,"[462, 161, 716, 191]",authors,0.6,"[""page-1 initial-lastname author byline: CLINICAL ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,6,doc_title,"The Correlation between Various Shoulder +Anatomical Indices on X-Ray and Subacromial +Impingement and Morphology of Rotator +Cuff Tears","[135, 218, 1056, 419]",paper_title,0.8,"[""page-1 zone title_zone: The Correlation between Various Shoulder\nAnatomical Indices ""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text,"Jinsong Yang, MD $ {}^{ID} $, Ming Xiang, PhD, Yiping Li, MD, Qing Zhang, MD $ {}^{ID} $, Fei Dai, MD $ {}^{ID} $","[213, 456, 976, 484]",authors,0.8,"[""page-1 zone author_zone: Jinsong Yang, MD $ {}^{ID} $, Ming Xiang, PhD, Yiping Li, M""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,8,text,"Sichuan Provincial Orthopedic Hospital Upper Arm Department, Chengdu, China","[297, 499, 893, 524]",affiliation,0.8,"[""page-1 zone affiliation_zone: Sichuan Provincial Orthopedic Hospital Upper Arm Department,""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,9,abstract,Objectives: Rotator cuff injury caused by subacromial impingement presents different morphologies. This study aims to investigate the correlation between various shoulder anatomical indexes on X-ray w,"[103, 583, 1084, 652]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,abstract,Method: This retrospective study was carried out between January 2020 and May 2022. Patients who were diagnosed as sub-acromial impingement associated with rotator cuff tears (without tendon retractio,"[103, 665, 1088, 844]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,11,abstract,Results: We analyzed 92 shoulders from 92 patients with a mean age of $ 57.23 \pm 8.45 $ years. The AS in anterior tear group ( $ 29.32 \pm 6.91^\circ $) was significantly larger than that in middle ,"[103, 859, 1088, 1058]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,12,abstract,Conclusion: Acromion with a larger AS and a smaller LAA tend to cause anterior or posterior rotator cuff tears rather than middle tears in sub-acromial impingement. Meanwhile acromion with a larger AS,"[102, 1071, 1087, 1139]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,13,text,Key words: Sub-Acromial impingement; Rotator cuff tear; Arthroscopy; Morphology; Shoulder anatomy,"[104, 1151, 957, 1176]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,14,paragraph_title,Introduction,"[77, 1238, 193, 1260]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,15,text,"Sub-acromial impingement is a common cause of shoulder pain and is also a crucial extrinsic predisposing factor for rotator cuff injury. $ ^{1,2} $ Shoulder standard A-P (anterior-posterior) view and ","[76, 1261, 583, 1311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,text,"factor for rotator cuff injury.1,2 Shoulder standard A-P +(anterior–posterior) view and outlet view on X-ray are the +most commonly used tools for the diagnosis of sub-","[606, 1237, 1114, 1311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,text,"Address for correspondence Ming Xiang, Sichuan Provincial Orthopedic Hospital Upper Arm Department, Chengdu, 610041, China. Email: joseceph_xm@sina.com +Received 30 August 2022; accepted 3 November 202","[75, 1362, 1109, 1418]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Address for correspondence Ming Xiang, Sichuan Provincial Or""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,18,footer,Orthopaedic Surgery 2023;15:1997-2006 · DOI: 10.1111/os.13610,"[78, 1473, 444, 1493]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,19,footer,"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is prope","[78, 1482, 1111, 1535]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,number,1998,"[565, 51, 627, 78]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328, 98, 581, 139]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,header,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[608, 99, 886, 119]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,text,"acromial impingement. $ ^{3-5} $ Previous studies have reported the correlation between various anatomical indices on shoulder X-ray and sub-acromial impingement. $ ^{6-9} $ However, no previous study","[74, 179, 583, 1101]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Therefore, the purpose of this study is to (i) summarize the shoulder anatomical indices and morphology of rotator cuff tear caused by subacromial impingement, (ii) investigate the correlation between","[75, 1100, 583, 1264]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,paragraph_title,Methods,"[77, 1284, 165, 1306]",section_heading,0.9,"[""explicit scholarly heading: Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,6,text,"Between January 2020 and May 2022, patients who were diagnosed as subacromial impingement associated with rotator cuff tear and received arthroscopic surgery were enrolled in this study. The study was","[75, 1307, 583, 1448]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"(1) the arthroscopic examination identified the tear was cau- +sed by impingement (the tear edge or surface was furry); +(2) there was no significant retraction of the rotator cuff; and +(3) the true anter","[606, 180, 1113, 409]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_parenthesis,True,True +2,8,text,"The radiographic indices of acromial slope (AS), acromial tilt (AT), lateral acromial angle (LAA), acromial Index (AI), and sub-acromial distance (SAD) were measured on preoperative true AP view and o","[605, 410, 1114, 689]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,paragraph_title,Measurement of Radiographic Indices Acromial Slope (AS),"[607, 709, 931, 777]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Measurement of Radiographic Indices Acromial Slope (AS)""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,False,True +2,10,footer,,"[607, 753, 779, 777]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,11,text,"AS was measured on the outlet-view X-ray. First, a line was drawn connecting the midway point and the most anterior point of the acromion inferior edge. Then, another line was drawn connecting the mid","[606, 777, 1114, 942]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,12,paragraph_title,Acromial Tilt (AT),"[607, 962, 769, 986]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Acromial Tilt (AT)""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,13,text,"The AT was measured on the outlet-view X-ray. First, a line was drawn connecting the most anterior point and the most posterior point of the acromion inferior edge. Then, another line was drawn connec","[606, 985, 1113, 1149]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,paragraph_title,Lateral Acromial Angle (LAA),"[607, 1169, 861, 1192]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Lateral Acromial Angle (LAA)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,15,text,"The LAA was measured on the true anteroposterior (AP)-view X-ray. First, a line was drawn connecting the uppermost point and the lowermost point of the lateral glenoid. Then, another line was drawn pa","[605, 1191, 1113, 1334]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,16,paragraph_title,Acromion Index (AI),"[607, 1353, 787, 1376]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Acromion Index (AI)""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +2,17,text,"The AI was measured on the true anteroposterior (AP) view X-ray. First, a lateral glenoid line was drawn connecting the uppermost point and the lowermost point of the lateral","[605, 1375, 1114, 1449]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,number,1999,"[566, 51, 626, 77]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328, 99, 581, 139]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,image,,"[367, 188, 1110, 1264]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,"Fig. 1 The various shoulder anatomical indices measured on X-ray. (A) acromial slope (AS), (B) acromial tilt (AT), (C) lateral acromial angle (LAA), (D) sub-acromial distance (SAD) and GA/GH-acromial ","[76, 1125, 349, 1292]",figure_caption,0.92,"[""figure_title label: Fig. 1 The various shoulder anatomical indices measured on X""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,"glenoid. Then, we measured the distance between the most lateral point of the acromion inferior edge and the lateral glenoid line as D1, and the distance between the most lateral point of the humeral ","[77, 1323, 583, 1465]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Sub-Acromial Distance (SAD),"[608, 1322, 856, 1347]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Sub-Acromial Distance (SAD)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,6,text,The SAD was measured on the true anteroposterior (AP) view X-ray. A line was drawn between the midpoint of the acromion inferior edge and the uppermost point of the humeral head. The length of the lin,"[606, 1345, 1115, 1464]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,2000,"[563, 51, 627, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,text,"ORTHOPAEDIC SURGERY +VOLUME 15·NUMBER 8·AUGUST, 2023 +SHOULDER ANATOMY AND ROTATOR CUFF TEAR","[327, 97, 581, 139]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,2,text,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[608, 99, 885, 119]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,Measurement of the Location and Morphology of Rotator Cuff Tears Tear Location in the Anterior to Posterior Direction,"[77, 180, 502, 270]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Measurement of the Location and Morphology of Rotator Cuff T""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,4,footer,,"[77, 248, 502, 270]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,5,text,Tear location must be viewed from a standard arthroscopic lateral portal. If the tear site was located in the anterior rotator cuff and the biceps tendon could be visually identified directly or by th,"[75, 272, 583, 571]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Tear Location in the Medial to Lateral Direction,"[77, 616, 476, 639]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Tear Location in the Medial to Lateral Direction""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,7,text,"Tear location should be viewed from a standard arthroscopic lateral portal. If the most lateral part of the tear was located more than 5 mm to the most lateral edge of the footprint, then the tear was","[75, 639, 581, 756]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,paragraph_title,Tear Morphology,"[77, 801, 226, 824]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Tear Morphology""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +4,9,text,"Tear location should be viewed from a standard arthroscopic lateral portal. If the tear ran in the medial to lateral direction, then the tear was defined as a longitudinal tear. If the tear ran in the","[74, 823, 583, 1010]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,All radiographic measurements were made by two experienced arthroscopic surgeons independently. Inter-observer consistency tests were performed and the average of the two measurements was taken as the,"[74, 1009, 582, 1196]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,paragraph_title,Statistical Analysis,"[77, 1238, 244, 1260]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical Analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,12,text,"SPSS version 22.0 (SPSS, Inc., Chicago, IL) was used to perform the statistical analysis. The comparisons of different radiographic indices between groups (anterior, middle, posterior group and horizo","[75, 1261, 582, 1471]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,paragraph_title,Results,"[608, 179, 687, 201]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,14,text,"In total, we analyzed 92 shoulders of 92 patients (33 males and 59 females). Mean age was $ 57.23 \pm 8.45 $ years. There were 64 right shoulders and 28 left shoulders. On average, $ 2.13 \pm 0.65 $","[603, 204, 1116, 805]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,15,paragraph_title,"Comparison between Groups of Different Tear Locations (Anterior, Middle, and Posterior)","[606, 824, 1086, 870]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Comparison between Groups of Different Tear Locations (Anter""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,16,text,"The radiographic indices in the anterior tear, middle tear, and posterior tear groups are shown in Table 2. The AS in the anterior tear group $ (29.32 \pm 6.91^\circ) $ was significantly larger than ","[605, 871, 1114, 1172]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,17,paragraph_title,"Comparison between Groups of Different Tear Shapes (Horizontal, Longitudinal, L-Shaped, and Irregular)","[605, 1192, 1063, 1238]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Comparison between Groups of Different Tear Shapes (Horizont""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,18,text,"The radiographic indices in the horizontal tear, longitudinal tear, L-shaped tear, and irregular tear groups are shown in Table 3. The AS in the longitudinal tear group (26.86 ± 8.41°) was significant","[605, 1239, 1114, 1470]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,2001,"[564, 51, 624, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328, 99, 581, 139]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,image,,"[168, 182, 1025, 939]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +5,3,figure_title,"Fig. 2 The different locations and shapes of rotator cuff tears caused by sub-acromial impingement. (A) Anterior tear, (B) middle tear, (C) posterior tear, (D) horizontal tear, (E) longitudinal tear, ","[77, 962, 1090, 1009]",figure_caption,0.92,"[""figure_title label: Fig. 2 The different locations and shapes of rotator cuff te""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,table,"
TABLE 1 General data of patients in each group
AntMidPosHoriLongL-shaIrrMed
TABLE 2 Comparison of radiographic indices between anterior tear, middle tear and posterior tear group
AS ( $ ^{\circ} $)AT ( $ ^{\circ} $","[81, 190, 1105, 408]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,2,chart,,"[92, 508, 574, 775]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,3,chart,,"[610, 504, 1096, 776]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,4,chart,,"[87, 802, 570, 1069]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,chart,,"[614, 800, 1102, 1072]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,6,chart,,"[359, 1099, 849, 1369]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,7,figure_title,"Fig. 3 Comparison of radiographic indices between the anterior tear, middle tear, and posterior tear groups. AS, acromial slope; AT, acromial tilt; LAA, lateral acromial angle; AI, acromial index; SAD","[77, 1392, 1090, 1439]",figure_caption,0.92,"[""figure_title label: Fig. 3 Comparison of radiographic indices between the anteri""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,0,figure_title,2003,"[562, 50, 628, 79]",figure_caption_candidate,0.85,"[""figure_title label: 2003""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False +7,1,table,"
TABLE 3 Comparison of radiographic indices in the horizontal tear, longitudinal tear, L-shaped tear and irregular tear group
AS ( $ ^{\circ} $)
TABLE 4 Comparison of radiographic indices in the medial tear and lateral tear group
AS ( $ ^{\circ} $)AT ( $ ^{\circ} $)LAA ( $ ","[81, 1144, 1104, 1344]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +8,4,vision_footnote,"Abbreviations: AI, acromial index; AS, acromial slope; AT, acromial tilt; LAA, lateral acromial angle; SAD, subacromial distance.","[97, 1320, 873, 1341]",footnote,0.7,"[""vision_footnote label: Abbreviations: AI, acromial index; AS, acromial slope; AT, a""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +8,5,text,"contact area was mainly a specific point; with shoulder abduction, the track was similar to a line running from medial to lateral. $ ^{25} $ However, if the contact area was a line, with shoulder abdu","[76, 1394, 583, 1465]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +8,6,text,"with shoulder abduction, the acromion edge worked like a +guillotine and a horizontal tear would be formed. Unlike the +medium to large rotator cuff tears (the L-shaped tear was","[605, 1393, 1114, 1466]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,0,header,2005,"[563, 50, 627, 79]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +9,1,header,"Orthopaedic Surgery +VOLUME 15 · NUMBER 8 · AUGUST, 2023","[328, 98, 581, 139]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +9,2,header,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[323, 98, 886, 138]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +9,3,text,"mainly formed by tendon retraction), the L-shaped tears observed in this study were caused by impingement. The contact area was not solitary; in contrast, the two contacting methods mentioned above (p","[74, 180, 584, 1127]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +9,4,paragraph_title,Clinical Translation,"[77, 1147, 254, 1168]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical Translation""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True +9,5,text,"The location of rotator cuff tears can differ; consequently, patients tend to complain about shoulder pain in different locations. Our analyses suggest that the location of potential rotator cuff tear","[74, 1169, 584, 1449]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +9,6,text,"be predicted from radiographic indices, thus allowing clini- +cians to guide the drug distribution.29 Patients with suba- +cromial impingement and poor radiographic indices may +require surgical interven","[604, 179, 1115, 598]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,7,paragraph_title,Strengths and Limitations,"[607, 622, 833, 645]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Strengths and Limitations""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True +9,8,text,"To the best of our knowledge, this is the first study to investigate the correlation between shoulder anatomical indices on X-ray and the morphology of rotator cuff tears with reliable statistical dat","[605, 645, 1114, 811]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,9,paragraph_title,Conclusion,"[608, 833, 710, 855]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True +9,10,text,"Acromion with a larger AS tend to cause anterior tears and middle tears rather than posterior tears, and is more likely to cause longitudinal tears rather than horizontal tears and L-shaped tears. Acr","[605, 856, 1114, 1043]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,11,paragraph_title,Acknowledgments,"[607, 1068, 781, 1090]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +9,12,text,"Thank you for the tacit teamwork of all authors. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.","[606, 1091, 1113, 1164]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,13,paragraph_title,Conflict of Interest,"[608, 1188, 786, 1210]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,True,True +9,14,text,The authors declared that they have no conflicts of interest for this work.,"[607, 1211, 1111, 1258]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,15,paragraph_title,Author's Contribution,"[608, 1284, 808, 1306]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author's Contribution""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True +9,16,text,"Jinsong Yang—study design, data collection, statistics, paper writing.","[608, 1308, 1113, 1353]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,17,text,Ming Xiang—operation implementation.,"[627, 1354, 966, 1378]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,18,text,Yiping Li—data collection.,"[628, 1377, 853, 1400]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,19,text,Qing Zhang—data collection.,"[628, 1401, 874, 1423]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,20,text,Fei Dai—data collection.,"[628, 1424, 836, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +10,0,header,2006,"[565, 52, 626, 78]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,1,text,"ORTHOPAEDIC SURGERY +SHOULDER ANATOMY AND ROTATOR CUFF TEAR","[438, 101, 580, 117]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,2,text,SHOULDER ANATOMY AND ROTATOR CUFF TEAR,"[609, 101, 885, 118]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,text,"VOLUME 15 · NUMBER 8 · AUGUST, 2023","[329, 119, 580, 137]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,paragraph_title,References,"[537, 216, 653, 236]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +10,5,reference_content,"1. 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Physical therap""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/tests/fixtures/ocr_real_papers/4FY3VQJS/block_trace.csv b/tests/fixtures/ocr_real_papers/4FY3VQJS/block_trace.csv new file mode 100644 index 00000000..168685b1 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/4FY3VQJS/block_trace.csv @@ -0,0 +1,92 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[83, 90, 187, 215]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header,Available online at www.sciencedirect.com,"[303, 90, 650, 114]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,header,ScienceDirect,"[344, 135, 608, 166]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,Materials Today: Proceedings 3 (2016) 2113–2120,"[309, 188, 645, 212]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,header_image,,"[771, 110, 1001, 176]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,5,header,www.materialstoday.com/proceedings,"[750, 191, 1002, 212]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,6,text,Recent Advances In Nano Science And Technology 2015 (RAINSAT2015),"[70, 351, 714, 378]",authors,0.8,"[""page-1 zone author_zone: Recent Advances In Nano Science And Technology 2015 (RAINSAT""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,doc_title,Structural Characterization of Silver-Hydroxyapatite Nanocomposite: A Bone Repair Biomaterial,"[179, 428, 902, 505]",unknown_structural,0.8,"[""page-1 zone author_zone: Structural Characterization of Silver-Hydroxyapatite Nanocom""]",authors,0.8,frontmatter_main_zone,support_like,none,False,True +1,8,text,"Amardeep Bharti $ ^{a,*} $, Suman Singh $ ^{b} $, Vijay Kumar Meena $ ^{b} $ and Navdeep Goyal $ ^{a} $","[126, 529, 956, 561]",authors,0.8,"[""page-1 zone author_zone: Amardeep Bharti $ ^{a,*} $, Suman Singh $ ^{b} $, Vijay Kuma""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,9,text," $ ^{a} $Department of physics, Panjab University, Chandigarh, INDIA-160014 + $ ^{b} $Central Scientific Instruments Organization, CSIR, Chandigarh, INDIA-160030","[277, 576, 804, 618]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $Department of physics, Panjab University, Chandigarh""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,10,paragraph_title,Abstract,"[70, 676, 145, 698]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,support_like,short_fragment,True,True +1,11,abstract,"Hydroxyapatite (HA) is a form of calcium & phosphate and constitutes large amount of human bone, dental enamel and dentin. HA is widely acceptable as purifier for proteins, drug delivery and body impl","[67, 721, 1012, 903]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,12,text,Selection and Peer-review under responsibility of [Conference Committee Members of Recent Advances In Nano Science and Technology 2015.].,"[70, 919, 988, 965]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,13,text,Keywords: Hydroxyapatite; Silver nanoparticles; Biomaterial; Anisotropic.,"[70, 985, 556, 1007]",structured_insert,0.7,"[""frontmatter noise text: Keywords: Hydroxyapatite; Silver nanoparticles; Biomaterial;""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,14,paragraph_title,1. Introduction,"[70, 1047, 206, 1069]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,15,text,"The area of biomaterials is an area of tremendous significance; engaged both material science and biological science, having aspiration to achieve a pertinent interaction between new material and huma","[68, 1094, 1016, 1142]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,footnote,* Corresponding author.,"[93, 1214, 259, 1234]",footnote,0.7,"[""footnote label: * Corresponding author.""]",footnote,0.7,body_zone,body_like,none,True,True +1,17,footnote,E-mail address: abharti@pu.ac.in,"[93, 1235, 319, 1255]",footnote,0.7,"[""footnote label: E-mail address: abharti@pu.ac.in""]",footnote,0.7,body_zone,body_like,none,True,True +1,18,footnote,2214-7853© 2015 Elsevier Ltd. All rights reserved.,"[70, 1277, 434, 1297]",footnote,0.7,"[""footnote label: 2214-7853\u00a9 2015 Elsevier Ltd. All rights reserved.""]",footnote,0.7,body_zone,body_like,none,True,True +1,19,footnote,Selection and Peer-review under responsibility of [Conference Committee Members of Recent Advances In Nano Science and Technology 2015].,"[70, 1295, 1005, 1338]",footnote,0.7,"[""footnote label: Selection and Peer-review under responsibility of [Conferenc""]",footnote,0.7,body_zone,body_like,none,True,True +2,0,number,2114,"[76, 93, 115, 111]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332, 93, 767, 112]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +2,2,text,"of world human population, traffic accidents and musculoskeletal disorders have become common which in turn increased the demand for implants. The major problem related to such implants is the risk of","[72, 136, 1023, 875]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: of world human population, traffic accidents and musculoskel""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,3,paragraph_title,2. Materials and Method,"[74, 897, 295, 919]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Method""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +2,4,text,"Hydroxyapatite nanoparticles were synthesized by chemical method and all the regents used were of high purity grade. Briefly, 0.3M ortho-phosphoric acid (H₃PO₄, 85 %, purchased from Merck) was added d","[74, 943, 1018, 1058]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,Silver nanoparticles were synthesized by seed-growth method and the resultant particles were anisotropic in nature. All the chemicals were of high purity grade: Silver nitrate (AgNO₃) & dextrose (C₆H₁,"[72, 1059, 1022, 1314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[339, 97, 776, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,2115,"[974, 97, 1012, 115]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,(1:4) were added. The sample was allowed to react overnight and the color of final solution turned grey. The final sample was centrifuged at 6000 rpm and washed with ethanol to produce the silver inco,"[68, 139, 1013, 210]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,3. Results and Discussions,"[69, 222, 302, 244]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and Discussions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,4,text,Transmission electron microscopy (TEM) is an excellent tool for the investigation of topology and morphology of nanomaterials. The electron micrographs of the AgNPs incorporated hydroxyapatite is show,"[67, 257, 1014, 373]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,figure_title,Table 1. Calculated parameters from electron micrograph.,"[68, 391, 444, 412]",table_caption,0.9,"[""table prefix matched: Table 1. Calculated parameters from electron micrograph.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,6,table,
Figure NameMean Particle Size ( $ S_{m} $)Standard Deviation ( $ \sigma $)Average NPs Size= $ S_{m} \pm \sigma $Polyispersity= $ \sigma / S_{m} \time,"[61, 418, 989, 520]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,7,text,XRD pattern of hydroxyapatite with and without the incorporation of anisotropic AgNPs for the structural investigation is shown in the Figure.2. XRD pattern of HA and HA+Ag is well matched with the IC,"[68, 544, 1012, 637]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,display_formula, $$ \chi_{c}=\frac{\sum A_{c}}{\sum A_{c}+\sum A_{a}} $$ ,"[464, 634, 616, 686]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +3,9,text,Where $ \sum A_c $ and $ \sum A_a $ is the total area under the crystalline and amorphous phase in the pattern respectively which could be calculated by integrating the curve over the desired phase.,"[67, 685, 1013, 825]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,display_formula, $$ \frac{1}{\mathrm{d}^{2}}=\frac{4}{3}\left(\frac{\mathrm{h}^{2}+\mathrm{k}^{2}+\mathrm{hk}}{\mathrm{a}^{2}}\right)+\frac{\mathrm{l}^{2}}{\mathrm{c}^{2}} $$ ,"[416, 822, 666, 875]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +3,11,text,"Where a, b, c are the lattice parameters, h, k, and l are miller indices. The calculated crystal parameters are reported in the Table.2.","[67, 878, 1013, 924]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,figure_title,Table 2. Calculated lattice parameter from XRD pattern.,"[70, 943, 434, 964]",table_caption,0.9,"[""table prefix matched: Table 2. Calculated lattice parameter from XRD pattern.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,13,table,
Sample NameCrystallinity ( $ \chi_{c} $) %d (Ao)Crystal Size D (nm)a (nm)b (nm)c (nm)
HA862.806<,"[61, 970, 989, 1056]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +3,14,text,"The presence of high intense diffraction peaks at $ 2\square = 38.19 $, 44.37, 64.51, 77.45, and 81.60 confirmed the presence of AgNPs with 24.6 nm crystal size in the HA matrix [14]. The crystal siz","[67, 1082, 1010, 1151]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,15,text,"is the Bragg angle. The reduction in the crystal size in case of nanocomposite is due to the presence of AgNPs which inhibit the growth of HA matrix at some extent, but still the crystal structure is ","[67, 1153, 1015, 1307]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,2116,"[76, 93, 115, 111]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +4,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332, 92, 767, 113]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +4,2,text," $ \chi_i's, = \left(\frac{k_i}{l_i}\sum_{i=1}^{n} \frac{l_i}{k_i}\right)^{-1} $, where $ n $ is the number of phases present in the mixture [15]. The sample HA contains hydroxyapatite single phase w","[72, 136, 1020, 269]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +4,3,chart,,"[203, 293, 577, 619]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,4,chart,,"[203, 639, 577, 933]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,5,image,,"[588, 290, 891, 593]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,6,image,,"[588, 604, 890, 905]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,7,chart,,"[206, 929, 581, 1239]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,8,image,,"[588, 910, 890, 1214]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +4,9,figure_title,Fig. 1. TEM images of Hydroxyapatite incorporated anisotropic AgNPs& corresponding size distribution histogram.,"[73, 1270, 824, 1292]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 1. TEM images of Hydroxyapatite incorporated anisotropi""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +5,0,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[340, 97, 776, 116]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +5,1,number,2117,"[973, 97, 1012, 115]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +5,2,chart,,"[198, 159, 897, 872]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +5,3,figure_title,Fig.2. XRD pattern of hydroxyapatite and silver-hydroxyapatite (HA+Ag) along with reference data card (Inset quantitative elemental analysis).,"[75, 895, 1006, 917]",figure_caption_candidate,0.85,"[""figure_title label: Fig.2. XRD pattern of hydroxyapatite and silver-hydroxyapati""]",figure_caption,0.85,tail_nonref_hold_zone,legend_like,none,False,False +5,4,chart,,"[250, 944, 814, 1272]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +5,5,figure_title,Fig.3. Fourier transform infrared spectroscopy (FTIR) spectra of HA and HA+Agnanocomposite.,"[69, 1282, 701, 1302]",figure_caption_candidate,0.85,"[""figure_title label: Fig.3. Fourier transform infrared spectroscopy (FTIR) spectr""]",figure_caption,0.85,tail_nonref_hold_zone,legend_like,none,False,False +6,0,number,2118,"[76, 92, 115, 111]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +6,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332, 92, 767, 112]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +6,2,chart,,"[150, 151, 931, 677]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +6,3,chart,,"[150, 727, 928, 1238]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +6,4,figure_title,Fig.4. Thermogravimetric analysis (TGA) spectra of HA and HA+Agnanocomposite.,"[74, 1258, 629, 1280]",figure_caption_candidate,0.85,"[""figure_title label: Fig.4. Thermogravimetric analysis (TGA) spectra of HA and HA""]",figure_caption,0.85,tail_nonref_hold_zone,legend_like,none,False,False +7,0,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[339, 97, 776, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,2119,"[973, 97, 1013, 115]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,text,The investigation of chemical structural composition of HA and HA+Ag was carried out by thermogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FTIR) also. The FTIR spectrum of H,"[66, 166, 1011, 383]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,image,,"[247, 401, 955, 502]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,4,figure_title,Fig.5. Proposed reaction mechanism of chemical synthesis of HA,"[68, 519, 498, 540]",figure_caption_candidate,0.85,"[""figure_title label: Fig.5. Proposed reaction mechanism of chemical synthesis of ""]",figure_caption,0.85,body_zone,legend_like,none,False,False +7,5,text,The 6.314% weight loss at 62.69 °C is attributed to the presence of water content in the sample which was confirmed by the absorption peak at 1631 cm⁻¹. The 10.76% weight loss corresponds to the PO₄ g,"[67, 564, 1011, 733]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,paragraph_title,4. Conclusion,"[69, 756, 193, 778]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Conclusion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,7,text,"In this study, structural characterization of hydroxyapatite with and without the incorporation of AgNPs has been investigated. Anisotropic AgNPs has been incorporated because of their enhanced antiba","[67, 804, 1014, 925]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,References,"[69, 996, 170, 1018]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +7,9,reference_content,"[1] T. Kim, J Periodontal Implant Sci. 44 (2014) 265-265.","[69, 1043, 449, 1062]",reference_item,0.85,"[""reference content label: [1] T. Kim, J Periodontal Implant Sci. 44 (2014) 265-265.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,10,reference_content,"[2] K. de Groot, ""Bioceramics Consisting of Calcium Phosphate Salts,"" Biomaterials. 1 (1900) 47-50.","[70, 1064, 727, 1083]",reference_item,0.85,"[""reference content label: [2] K. de Groot, \""Bioceramics Consisting of Calcium Phosphat""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,11,reference_content,"[3] F. Chenab, Y. Zhub, J. Wub, P. Huanga, D. Cuia, Nano Biomed. Eng. 4 (2012) 41-49.","[71, 1084, 652, 1103]",reference_item,0.85,"[""reference content label: [3] F. Chenab, Y. Zhub, J. Wub, P. Huanga, D. Cuia, Nano Bio""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,12,reference_content,"[4] N. Rameshbabu, T. S. S. Kumar, T.G. Prabhakar, V.S. Sastry, K.V.G.K. Murty, K. P. Rao, Journal of Biomedical Materials Research Part A. 80, (2007) 581-591.","[71, 1104, 1001, 1142]",reference_item,0.85,"[""reference content label: [4] N. Rameshbabu, T. S. S. Kumar, T.G. Prabhakar, V.S. Sast""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,13,reference_content,"[5] A. Bharti, S. Singh, V. K. Meena, and N. Goyal, Advanced Science Letters, 20 (2014) 1297–1302.","[70, 1143, 732, 1163]",reference_item,0.85,"[""reference content label: [5] A. Bharti, S. Singh, V. K. Meena, and N. Goyal, Advanced""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,14,reference_content,"[6] E. Ismail, M.B. Mohamed, A. Mostafa, H. Oudadesse, G. Kamal, Journal of Advances in Chemistry. 11 (2015) 3559-3566.","[71, 1163, 897, 1182]",reference_item,0.85,"[""reference content label: [6] E. Ismail, M.B. Mohamed, A. Mostafa, H. Oudadesse, G. Ka""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,15,reference_content,"[7] G. Liu, J. W. Talley, C. Na, S. L. Larson, L. G. Wolfe, Environ. Sci. Technol. (2009).","[70, 1183, 649, 1202]",reference_item,0.85,"[""reference content label: [7] G. Liu, J. W. Talley, C. Na, S. L. Larson, L. G. Wolfe, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,16,reference_content,"[8] S. Dasgupta, S. S. Banerjee, A. Bandyopadhyay, S. Bose, Langmuir, 26 (2010) 4958–4964.","[71, 1203, 685, 1221]",reference_item,0.85,"[""reference content label: [8] S. Dasgupta, S. S. Banerjee, A. Bandyopadhyay, S. Bose, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,17,reference_content,"[9] S. L. Iconaru, M. M. Heino, D. Predoi, Journal of Spectroscopy. (2013) 284285.","[70, 1222, 613, 1242]",reference_item,0.85,"[""reference content label: [9] S. L. Iconaru, M. M. Heino, D. Predoi, Journal of Spectr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,18,reference_content,"[10] N. Rameshbabu, T.S. Kumar, T.G. Prabhakar, K.P. Rao, Journal of Biomedical Materials Research Part A, (2006) 581-591.","[71, 1243, 897, 1262]",reference_item,0.85,"[""reference content label: [10] N. Rameshbabu, T.S. Kumar, T.G. Prabhakar, K.P. Rao, Jo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,19,reference_content,"[11] S. Pal, Y. K. Tak, and J. M. Song, Applied and Environmental Microbiology, (2007) 1712-1720.","[71, 1263, 728, 1282]",reference_item,0.85,"[""reference content label: [11] S. Pal, Y. K. Tak, and J. M. Song, Applied and Environm""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +7,20,reference_content,"[12] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater Electron, (2015).","[71, 1284, 561, 1303]",reference_item,0.85,"[""reference content label: [12] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater El""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,0,number,2120,"[77, 94, 115, 110]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +8,1,header,Author name / Materials Today: Proceedings 3 (2016) 2113–2120,"[332, 94, 767, 112]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +8,2,reference_content,"[15] w. Chen, S. On, A. P. Ong, N. Oh, Y. Liu, H. S. Courtney, M. Appleford, J. L. Ong, Journal of Biomedical Materials Research Part A, (2006).","[78, 137, 977, 176]",reference_item,0.85,"[""reference content label: [15] w. Chen, S. On, A. P. Ong, N. Oh, Y. Liu, H. S. Courtne""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,3,reference_content,"[14] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater Electron, 25 (2014) 3747–3752.","[77, 178, 662, 194]",reference_item,0.85,"[""reference content label: [14] S. Singh, A. Bharti, V. K. Meena, J Mater Sci: Mater El""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,4,reference_content,"[15] F. H. Chung, J. Appl. Cryst. 8 (1975) 17-19.","[78, 198, 397, 215]",reference_item,0.85,"[""reference content label: [15] F. H. Chung, J. Appl. Cryst. 8 (1975) 17-19.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,5,reference_content,"[16] A. A. Shaltout, M. A. Allam, M. A. Moharram, Spectrochimica Acta Part A, 83 (2011) 56-60.","[78, 219, 715, 236]",reference_item,0.85,"[""reference content label: [16] A. A. Shaltout, M. A. Allam, M. A. Moharram, Spectrochi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True diff --git a/tests/fixtures/ocr_real_papers/4KCHGV2Z/block_trace.csv b/tests/fixtures/ocr_real_papers/4KCHGV2Z/block_trace.csv new file mode 100644 index 00000000..f9e742bb --- /dev/null +++ b/tests/fixtures/ocr_real_papers/4KCHGV2Z/block_trace.csv @@ -0,0 +1,172 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,"Clin Orthop Relat Res (2010) 468:1542–1550 +DOI 10.1007/s11999-009-1058-5","[98, 64, 425, 109]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,text,CLINICAL RESEARCH,"[110, 127, 342, 153]",authors,0.6,"[""page-1 initial-lastname author byline: CLINICAL RESEARCH""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,2,doc_title,Classification and Clinical Significance of Acromial Spur in Rotator Cuff Tear,"[96, 211, 893, 282]",paper_title,0.8,"[""page-1 zone title_zone: Classification and Clinical Significance of Acromial Spur in""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,Heel-type Spur and Rotator Cuff Tear,"[96, 298, 509, 328]",authors,0.8,"[""page-1 zone author_zone: Heel-type Spur and Rotator Cuff Tear""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"Joo Han Oh MD, PhD, Jae Yoon Kim MD, Ho Kyoo Lee MD, Jung-Ah Choi MD, PhD","[95, 360, 486, 412]",authors,0.8,"[""page-1 zone author_zone: Joo Han Oh MD, PhD, Jae Yoon Kim MD, Ho Kyoo Lee MD, Jung-Ah""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,Received: 12 February 2009 / Accepted: 10 August 2009 / Published online: 4 September 2009,"[96, 485, 761, 507]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 12 February 2009 / Accepted: 10 August 2009 / Publ""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,6,text,© The Association of Bone and Joint Surgeons $ ^{\textregistered} $ 2009,"[97, 506, 494, 528]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 The Association of Bone and Joint Surgeons $ ^{\\textregist""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,7,abstract,Abstract Acromial spurs reportedly relate to the impingement syndrome and rotator cuff tears. We classified the morphologic characteristics of the acromion (shape and thickness) and acromial spurs and,"[96, 563, 583, 888]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,8,abstract,group. The heel type was most common and detected in 59 patients (56%) in the cuff tear group and in 36 patients (35%) in the control group. The flat acromion was more common (60%) than curved and hoo,"[604, 563, 1094, 834]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,9,text,"Level of Evidence: Level IV, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.","[606, 836, 1093, 911]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,10,footnote,"Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in ","[97, 932, 582, 1012]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Each author certifies that he or she has no commercial assoc""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,paragraph_title,Introduction,"[607, 962, 725, 986]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,12,footnote,Each author certifies that his or her institution has approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research. T,"[97, 1013, 580, 1115]",footnote,0.7,"[""footnote label: Each author certifies that his or her institution has approv""]",footnote,0.7,body_zone,body_like,none,True,True +1,13,text,"Rotator cuff disorder is a common cause of chronic shoulder pain in adults. The specific etiology of a rotator cuff tear has not been fully elucidated, but it has been considered to result from a comb","[605, 1011, 1093, 1236]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,footnote,"J. H. Oh, H. K. Lee +Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Korea","[96, 1131, 538, 1217]",footnote,0.7,"[""footnote label: J. H. Oh, H. K. Lee\nDepartment of Orthopedic Surgery, Seoul ""]",footnote,0.7,body_zone,body_like,none,True,True +1,15,footnote,"J. Y. Kim (✉) +Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, 224-1, Heukseok-Dong, Dongjak-ku, Seoul 156-755, Korea +e-mail: orthozan@hanmail.net","[95, 1232, 523, 1335]",footnote,0.7,"[""footnote label: J. Y. Kim (\u2709)\nDepartment of Orthopaedic Surgery, Chung-Ang U""]",footnote,0.7,body_zone,body_like,none,True,True +1,16,footnote,"J.-A. Choi +Department of Radiology, Seoul National University College +of Medicine, Seoul National University Bundang Hospital, +Seoul, Korea","[96, 1352, 532, 1434]",footnote,0.7,"[""footnote label: J.-A. Choi\nDepartment of Radiology, Seoul National Universit""]",footnote,0.7,body_zone,body_like,none,True,True +1,17,text,"The coracoacromial ligament [9, 10, 20], shape of the acromion [2, 3, 25], and formation of acromial spurs [21, 26] reportedly relate to impingement and their association with rotator cuff tears has b","[605, 1236, 1094, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,18,footer_image,,"[99, 1470, 187, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,0,header,"Volume 468, Number 6, June 2010","[98, 65, 352, 86]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,Heel-type Spur and Rotator Cuff Tear,"[762, 65, 1035, 87]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,number,1543,"[1053, 65, 1091, 84]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,3,text,"enlarge the subacromial space and decompress the rotator cuff. Numerous subsequent studies [2, 3, 8, 17, 21, 25, 26] have supported Neer's theory of extrinsic impingement leading to cuff disease and c","[95, 115, 583, 239]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,Various relationships reportedly occur between acromial spurs and rotator cuff tear. Ogawa et al. [21] classified acromial spurs according to size and emphasized only large spurs measuring 5 mm or gre,"[96, 239, 583, 736]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Therefore, the purposes of our study were (1) to classify the morphologic characteristics of acromial spurs in rotator cuff disorder; and (2) to evaluate the clinical correlation of acromial character","[95, 738, 583, 863]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,paragraph_title,Materials and Methods,"[97, 913, 308, 935]",section_heading,0.9,"[""explicit scholarly heading: Materials and Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +2,7,text,We retrospectively reviewed the prospectively collected data from all 106 patients with full-thickness rotator cuff tears who underwent rotator cuff repair surgery between July 2007 and September 2008,"[95, 961, 584, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,text,"shoulders, fractures, and tumors. There were 54 men and +48 women with an average age of 57.5 years (range, 45– +79 years) in the control group. We observed no difference +in age and gender ratio between","[605, 116, 1093, 214]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"We evaluated plain radiographs, including shoulder true AP, lateral, axial, supraspinatus outlet, and 30° caudal tilt view; MRA or CTA also was performed in all patients. Acromial thickness, shape, an","[604, 215, 1094, 614]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,figure_title,Table 1. Demographic data for both patient groups,"[607, 650, 979, 671]",table_caption,0.9,"[""table prefix matched: Table 1. Demographic data for both patient groups""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +2,11,table,"
Demographic characteristicsRotator cuff tear group (n = 106)Control group (n = 102)
Mean age (years)59.6 (range, 49-78)57.5 (range, ","[607, 675, 1090, 793]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +2,12,inline_formula, $$ p>0.05. $$ ,"[609, 799, 678, 821]",unknown_structural,0.2,"[""unrecognized label 'inline_formula'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,short_fragment,False,True +2,13,image,,"[616, 869, 1083, 1331]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,14,figure_title,Fig. 1 Acromial thickness was measured at the widest portion of the acromion on the perpendicular plane to the long axis of the acromion on the oblique sagittal image plane just lateral to the acromio,"[606, 1354, 1093, 1434]",figure_caption,0.92,"[""figure_title label: Fig. 1 Acromial thickness was measured at the widest portion""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,15,footer_image,,"[1004, 1470, 1091, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,0,number,1544,"[100, 65, 139, 84]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,Oh et al.,"[156, 65, 222, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,header,Clinical Orthopaedics and Related Research $ ^{®} $,"[764, 64, 1090, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,3,text,"interobserver reliability, acromial spur types were redetermined independently by two orthopaedic surgeons (HKL, SKL) after the classification scheme of acromial spurs was explained to them. The kappa","[95, 116, 583, 289]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,"We used Student's t-test to compare continuous variables (age, acromial thickness, and tear size) between the two groups. The chi square test was used to evaluate discrete variables (gender, acromial ","[95, 290, 583, 489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,Results,"[97, 538, 169, 561]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,6,text,"We observed distinct morphologic types of acromial spurs and categorized them into heel, lateral/anterior traction, lateral/anterior bird beak, and medial types. The quadrangular spur protruded inferi","[95, 588, 583, 713]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"type spur (Fig. 2). Laterally protruding spurs were seen +with the lateral traction and lateral bird beak-type spurs in +the coronal plane. The lateral traction-type spur was con- +gruent with the acromi","[604, 117, 1094, 487]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"We detected acromial spurs in 142 of the 208 patients (68%), and their incidence increased with age. The acromial spurs were detected more frequently (p = 0.006) in patients older than 65 years (80%) ","[604, 488, 1094, 714]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,figure_title,Fig. 2A–D (A) The inferior bony projection that looks like the heel of a shoe is shown in this diagram. This kind of spur was categorized as a heel-type spur. The heel-type spur can be seen on the (B),"[96, 754, 340, 939]",figure_caption,0.92,"[""figure_title label: Fig. 2A\u2013D (A) The inferior bony projection that looks like t""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,10,image,,"[365, 760, 1090, 1431]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,11,footer_image,,"[98, 1470, 187, 1498]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +4,0,header,"Volume 468, Number 6, June 2010","[98, 65, 352, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header,Heel-type Spur and Rotator Cuff Tear,"[762, 65, 1034, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,number,1545,"[1053, 66, 1091, 83]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,figure_title,Fig. 3A–B (A) The acromial spur is located at the lateral end of the acromion and is congruent with the acromial undersurface or parallel to the direction of the rotator cuff. This kind of spur was ca,"[96, 112, 339, 295]",figure_caption,0.92,"[""figure_title label: Fig. 3A\u2013B (A) The acromial spur is located at the lateral en""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,4,image,,"[102, 113, 1087, 828]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +4,5,figure_title,Fig. 4A–C (A) The acromial spur is located at the lateral end of the acromion. It is not congruent with the acromial undersurface or the rotator cuff. This spur was categorized as a bird beak spur and,"[96, 848, 1090, 890]",figure_caption,0.92,"[""figure_title label: Fig. 4A\u2013C (A) The acromial spur is located at the lateral en""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,6,text,"subjects [58%] (Table 2). Spurs were more frequent (p = 0.002) in patients with full-thickness cuff tears than in the control group. However, they were not related (p = 0.700, 0.248, respectively) wit","[95, 938, 583, 1210]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"One hundred twenty-five patients (60%) had a flat-type acromion, 60 (28%) had the curved type, and 23 (11%) had the hooked type. There were no differences (p = 0.124) in the distribution of each acrom","[95, 1212, 583, 1436]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"thicker (p = 0.014) than those in the control group +(Table 4). Acromions were thicker in men than in women +although the two-way ANOVA showed gender was not a +confounding factor because there was no in","[604, 938, 1094, 1061]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,Discussion,"[608, 1111, 706, 1134]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +4,10,text,"Acromial spurs apparently form by traction of the coracoacromial ligament and reportedly are related to rotator cuff tears [5, 9, 20, 21, 26], although it is debatable whether it is the cause of a rot","[604, 1161, 1094, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,footer_image,,"[1003, 1471, 1091, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,0,number,1546,"[101, 66, 139, 84]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,Oh et al.,"[157, 66, 222, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,header,Clinical Orthopaedics and Related Research $ ^{®} $,"[765, 64, 1088, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,3,figure_title,Fig. 5A–D (A) This diagram illustrates the spur located at the medial end of the acromion or distal end of the clavicle. It was categorized as a medial-type spur and can be seen on a (B) simple radiog,"[97, 113, 340, 276]",figure_caption,0.92,"[""figure_title label: Fig. 5A\u2013D (A) This diagram illustrates the spur located at t""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,image,,"[367, 118, 728, 467]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,image,,"[737, 120, 1089, 405]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,image,,"[366, 476, 730, 764]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,7,image,,"[737, 414, 1089, 762]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,text,acromial spurs and rotator cuff tears. This could provide useful guidance regarding the diagnosis and treatment of rotator cuff tears.,"[95, 811, 583, 885]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,9,text,"There are certain limitations to our study. First, spur classification by morphology is somewhat subjective, although interobserver and intraobserver reliability were 0.766/0.734 in the coronal plane ","[95, 888, 584, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"substantial number of patients, including a healthy popu- +lation, would be needed to completely confirm the +relationship between acromial spurs and rotator cuff tears. +Finally, there were 59 patients w","[604, 811, 1094, 1310]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,Ogawa et al. [21] classified acromial spurs according to size and emphasized only large spurs measuring 5 mm or greater are of diagnostic value because of the high rate of association with the bursal-,"[604, 1310, 1095, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,footer_image,,"[99, 1471, 187, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +6,0,header,"Volume 468, Number 6, June 2010","[98, 65, 351, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header,Heel-type Spur and Rotator Cuff Tear,"[763, 65, 1034, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,2,number,1547,"[1053, 66, 1091, 84]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,3,figure_title,"Fig. 6A–D (A) The diagram illustrates the anterior bony projection along with the coracoacromial ligament and the spur, which is congruent with the acromial undersurface or parallel to the rotator cuf","[97, 113, 340, 395]",figure_caption,0.92,"[""figure_title label: Fig. 6A\u2013D (A) The diagram illustrates the anterior bony proj""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,4,image,,"[366, 122, 610, 469]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,image,,"[621, 119, 1089, 464]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,6,image,,"[367, 474, 731, 823]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,7,image,,"[736, 474, 1090, 822]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,text,"morphologic characteristics, because we noticed some acromial spurs share their typical shape. The mechanisms of each type of spur formation are unclear, but we presumed traction spurs were formed by ","[96, 885, 584, 1432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"tears. However, we observed an association of full-thick- +ness rotator cuff tears and the heel-type acromial spur. +Patients with partial rotator cuff tears and heel-type spurs +seen on MRI or with heel","[605, 884, 1093, 1057]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"There are numerous theories regarding the causative factors of rotator cuff tears, and none fully explain the etiology. Acromial spurs are a potential causative factor of rotator cuff tears. However, ","[604, 1059, 1095, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,footer_image,,"[1004, 1471, 1091, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +7,0,number,1548,"[101, 65, 139, 84]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +7,1,header,Oh et al.,"[157, 66, 222, 85]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +7,2,header,Clinical Orthopaedics and Related Research $ ^{®} $,"[766, 64, 1088, 86]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +7,3,text,Fig. 7A–D (A) The anteroinferior bony projection has the appearance of a bird beak. It is neither congruent with the acromial undersurface nor parallel to the rotator cuff. This type of spur was categ,"[96, 113, 339, 375]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Fig. 7A\u2013D (A) The anteroinferior bony projection has the app""]",figure_caption_candidate,0.9,tail_nonref_hold_zone,legend_like,figure_number,True,True +7,4,image,,"[365, 114, 682, 488]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,5,image,,"[700, 118, 1090, 389]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,6,figure_title,B,"[707, 369, 727, 391]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +7,7,image,,"[367, 504, 696, 782]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,8,image,,"[700, 401, 1090, 782]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,9,chart,,"[103, 815, 575, 1121]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +7,10,figure_title,Fig. 8 The incidence of acromial spurs increased with advancing age. Patients younger than 55 years had a lower incidence of spurs than older patients. There was no major difference between the 55- to,"[96, 1137, 582, 1221]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 8 The incidence of acromial spurs increased with advanc""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +7,11,text,"Since Neer [15, 16] reported the impingement theory and rotator cuff tears, numerous studies [2, 3, 8, 12, 17, 21, 23, 25, 26] have elucidated the details of the association","[96, 1361, 582, 1434]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,12,text,"than 5 mm were associated with rotator cuff tears. Our data suggest the incidence of acromial spurs increases with age, and acromial spurs, especially the heel type, are more frequent in patients with","[95, 1261, 582, 1359]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,13,figure_title,Table 2. Relationship between the type of acromial spur and rotator cuff tear,"[606, 822, 1091, 865]",table_caption,0.9,"[""table prefix matched: Table 2. Relationship between the type of acromial spur and ""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +7,14,table,
Classification of acromial spursRotator cuff tear group (n = 106)Control group (n = 102)Total (n = 208)
Acromial spur83 $ ^{*} $ (78,"[607, 860, 1092, 1161]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +7,15,vision_footnote, $ ^{*} $ Significant difference between the two groups (p < 0.05).,"[608, 1169, 1030, 1191]",footnote,0.7,"[""vision_footnote label: $ ^{*} $ Significant difference between the two groups (p < ""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,affiliation_marker,True,True +7,16,figure_title,Table 3. Size of full-thickness rotator cuff tears according to the acromial spur,"[606, 1240, 1091, 1282]",table_caption,0.9,"[""table prefix matched: Table 3. Size of full-thickness rotator cuff tears according""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +7,17,table,
Index groupAnteroposterior dimension (cm)Retraction (cm)
Acromial spur (+) (n = 83)2.242.27
Acromial spur (−) (n = ,"[606, 1289, 1090, 1406]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +7,18,inline_formula, $$ p>0.05. $$ ,"[608, 1409, 679, 1432]",unknown_structural,0.2,"[""unrecognized label 'inline_formula'""]",unknown_structural,0.2,tail_nonref_hold_zone,unknown_like,short_fragment,False,True +7,19,footer_image,,"[98, 1470, 187, 1497]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,tail_nonref_hold_zone,unknown_like,empty,False,True +8,0,header,"Volume 468, Number 6, June 2010","[98, 65, 352, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header,Heel-type Spur and Rotator Cuff Tear,"[762, 65, 1035, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,2,number,1549,"[1053, 66, 1091, 84]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,3,figure_title,"Table 4. Relationship among acromial thickness, shape, and full-thickness rotator cuff tear","[97, 117, 581, 157]",table_caption,0.9,"[""table prefix matched: Table 4. Relationship among acromial thickness, shape, and f""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +8,4,table,"
Morphologic characteristics of acromionRotator cuff tear group (n = 106)Control group (n = 102)Total (n = 208)
Acromial shape
VariablesSAIS suspected cases +n=680
Age
≤50327 (48.1%)
>50353 (51.9%)
Type I acromionType II acromionType III acromionType IV acromionMild AC degenerative changesModerate AC degenerative changes
VariablesSAIS
YesN(%)NoN(%)P-value
Gender
Male<","[104, 147, 1084, 1508]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +6,3,footer,Orthopedic Reviews,"[534, 1622, 656, 1639]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +6,4,number,6,"[1068, 1619, 1085, 1642]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +7,0,header,Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial...,"[249, 45, 938, 65]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +7,1,paragraph_title,ACKNOWLEDGMENTS,"[104, 110, 291, 135]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,False,True +7,2,text,The author is thankful to all the associated personnel who contributed to this study by any means.,"[102, 155, 587, 207]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +7,3,text,AUTHOR'S CONTRIBUTION,"[103, 226, 336, 253]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,4,text,"Single Author paper, all contributions are made by R.A","[102, 271, 552, 299]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,5,text,CONFLICTING INTERESTS,"[103, 318, 326, 346]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,6,text,The Author(s) declare(s) that there is no conflict of interest.,"[102, 364, 586, 390]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True +7,7,paragraph_title,FUNDING,"[602, 110, 690, 135]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level section_heading: FUNDING""]",section_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,False,True +7,8,text,"The author(s) received no financial support for the re-search, authorship, and/or publication of this article.","[601, 154, 1085, 207]",frontmatter_noise,0.7,"[""keyword-like block: The author(s) received no financial support for the re-searc""]",frontmatter_noise,0.7,tail_nonref_hold_zone,unknown_like,none,False,False +7,9,text,"Submitted: April 07, 2025 EDT. Accepted: May 11, 2025 EDT. Published: July 09, 2025 EDT.","[602, 231, 1063, 285]",frontmatter_noise,0.7,"[""keyword-like block: Submitted: April 07, 2025 EDT. Accepted: May 11, 2025 EDT. P""]",frontmatter_noise,0.7,tail_nonref_hold_zone,unknown_like,none,False,False +7,10,footer,Orthopedic Reviews,"[535, 1622, 656, 1640]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +7,11,number,7,"[1068, 1618, 1085, 1642]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +8,0,header,Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial...,"[249, 45, 937, 65]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,paragraph_title,REFERENCES,"[514, 119, 676, 147]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +8,2,reference_content,1. Dhillon KS. Subacromial Impingement Syndrome of the Shoulder: A Musculoskeletal Disorder or a Medical Myth? MOJ. 2019;13(3):1-7. doi:10.5704/moj.1911.001,"[125, 212, 547, 304]",reference_item,0.85,"[""reference content label: 1. Dhillon KS. Subacromial Impingement Syndrome of the Shoul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,3,reference_content,"2. Utkan Karasu A, Kılıç A, Karaoğlan B. Efficacy of Transcutaneous Pulsed Radiofrequency Treatment in Subacromial Impingement Syndrome: A Randomized Controlled Study. J Clin Med. 2024;13(23):7462. do","[125, 332, 559, 445]",reference_item,0.85,"[""reference content label: 2. Utkan Karasu A, K\u0131l\u0131\u00e7 A, Karao\u011flan B. Efficacy of Transcu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,4,reference_content,"3. Park HJ, Lee SY, Choi YJ, et al. Association Between Subacromial Impingement and Acromiohumeral Distance on MRI. 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Epstein RE, Schweitzer ME, Frieman BG, et al. Hooked acr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,23,reference_content,"22. Chun JM, Yoo HW. Incidence of the acromial spur. J Shoulder Elbow Surg. 1994;3(Suppl):S20.","[624, 1525, 1061, 1572]",reference_item,0.85,"[""reference content label: 22. Chun JM, Yoo HW. Incidence of the acromial spur. J Shoul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +8,24,footer,Orthopedic Reviews,"[534, 1621, 656, 1640]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +8,25,number,8,"[1069, 1619, 1084, 1641]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +9,0,header,Acromion Shape and Degenerative Changes of the Acromioclavicular Joint as Risk Factors for Sub-Acromial...,"[250, 45, 937, 65]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +9,1,reference_content,"23. Farley TE, Neumann CH, Steinbach LS, et al. The coracoacromial arch: MR evaluation and correlation with rotator cuff pathology. Skeletal Radiol. 1994;23:641-645. doi:10.1007/bf02580386","[126, 108, 552, 200]",reference_item,0.85,"[""reference content label: 23. Farley TE, Neumann CH, Steinbach LS, et al. 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J Shoulder Elbow Surg. 2002;11(6):576-578. doi:10.1067/mse.2002.127097","[126, 754, 542, 846]",reference_item,0.85,"[""reference content label: 28. Hirano M, Ide J, Takagi K. Acromial shapes and extension""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,7,reference_content,29. Almekinder LC. Impingement syndrome. Clin Sports Med. 2001;20(3):491-504. doi:10.1016/S0278-5919(05)70265-9,"[626, 109, 1023, 178]",reference_item,0.85,"[""reference content label: 29. Almekinder LC. Impingement syndrome. Clin Sports Med. 20""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,8,reference_content,"30. Consigliere P, Haddo O, Levy O, et al. Subacromial impingement syndrome: management challenges. J Orthop Res. 2018;23:83-91. doi:10.2147/orr.s157864","[625, 206, 1063, 277]",reference_item,0.85,"[""reference content label: 30. Consigliere P, Haddo O, Levy O, et al. Subacromial impin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,9,reference_content,"31. Dalbøge A, Frost P, Andersen JH, et al. Exposure-response relationships between cumulative occupational shoulder exposures and different diagnoses related to surgery for subacromial impingement sy","[626, 303, 1063, 462]",reference_item,0.85,"[""reference content label: 31. Dalb\u00f8ge A, Frost P, Andersen JH, et al. Exposure-respons""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,10,reference_content,"32. Yao L, Lee HY, Gentili A, et al. Lateral down-sloping of the acromion: a useful MR sign? Clin Radiol. 1996;51(12):869-872. doi:10.1016/s0009-9260(96)80085-7","[625, 491, 1018, 583]",reference_item,0.85,"[""reference content label: 32. Yao L, Lee HY, Gentili A, et al. Lateral down-sloping of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,11,reference_content,"33. Almokhtar AA, Qanat AS, Mulla A, et al. Relationship between acromial anatomy and rotator cuff tears in Saudi Arabian population. Cureus. 2020;12(9):e10726. doi:10.7759/cureus.8304. PMID:32601576","[626, 611, 1050, 726]",reference_item,0.85,"[""reference content label: 33. Almokhtar AA, Qanat AS, Mulla A, et al. Relationship bet""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,12,reference_content,"34. Paavola M, Kanto K, Ranstam J, et al. Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: a 5-year follow-up of a randomised, placebo surgery controlled clinical tria","[625, 753, 1060, 890]",reference_item,0.85,"[""reference content label: 34. Paavola M, Kanto K, Ranstam J, et al. Subacromial decomp""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +9,13,footer,Orthopedic Reviews,"[535, 1622, 656, 1640]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,short_fragment,False,False +9,14,number,9,"[1068, 1618, 1085, 1641]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/4M64NZEC/block_trace.csv b/tests/fixtures/ocr_real_papers/4M64NZEC/block_trace.csv new file mode 100644 index 00000000..f7b0566a --- /dev/null +++ b/tests/fixtures/ocr_real_papers/4M64NZEC/block_trace.csv @@ -0,0 +1,123 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,论 著,"[100, 87, 171, 112]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header,影像研究与医学应用 2025年5月 第9卷第10期,"[366, 85, 837, 110]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,doc_title,MRI 检查在冻结肩诊断中的应用价值分析,"[244, 140, 977, 183]",paper_title,0.8,"[""page-1 zone title_zone: MRI \u68c0\u67e5\u5728\u51bb\u7ed3\u80a9\u8bca\u65ad\u4e2d\u7684\u5e94\u7528\u4ef7\u503c\u5206\u6790""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,乔祖康 $ ^{1} $,戴程炜 $ ^{2} $,徐海鹏 $ ^{1} $,熊俊龙 $ ^{1} $,赵沈阳 $ ^{1} $,常红生 $ ^{1} $(通信作者),"[283, 212, 932, 236]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,text,"(1 浙江中医药大学附属第一医院 < 浙江省中医院 > 医学影像科 浙江 杭州 310006) +(2 浙江中医药大学第三临床医学院 浙江 杭州 310053)","[228, 239, 996, 294]",unknown_structural,0.8,"[""page-1 zone title_zone: (1 \u6d59\u6c5f\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 < \u6d59\u6c5f\u7701\u4e2d\u533b\u9662 > \u533b\u5b66\u5f71\u50cf\u79d1 \u6d59\u6c5f \u676d\u5dde 310006)\n(2 \u6d59\u6c5f\u4e2d\u533b\u836f\u5927\u5b66\u7b2c\u4e09""]",paper_title,0.8,frontmatter_main_zone,support_like,none,False,True +1,5,abstract,【摘要】目的:探讨肩关节MRI在冻结肩(FS)的临床及影像诊断中的应用价值。方法:选取2022年8月—2023年8月浙江中医药大学附属第一医院收治的30例处于冻结期的FS患者作为观察组,并选取同期30名健康成人作为对照组。通过MRI测量两组的喙肱韧带(CHL)、腋囊(AR)和下盂肱韧带(IGHL)的厚度,并绘制受试者工作特征(ROC)曲线评估CHL、AR、IGHL厚度对FS的诊断价值,计算曲线下面,"[98, 347, 1126, 587]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,6,text,【关键词】冻结肩;磁共振成像;喙肱韧带;腋囊;下盂肱韧带;诊断价值,"[104, 595, 684, 620]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,7,text,【中图分类号】R445.2,"[105, 626, 295, 652]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True +1,8,text,【文献标识码】A,"[452, 626, 600, 652]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True +1,9,text,DOI:10.20267/j.issn.2096-3807.2025.10.002,"[768, 628, 1127, 651]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,False,False +1,10,doc_title,Analysis of the application value of MRI examination in the diagnosis of frozen shoulder,"[97, 708, 789, 733]",paper_title,0.6,"[""page-1 frontmatter title guard: Analysis of the application value of MRI examination in the ""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,11,text,"QIAO Zukang $ ^{1} $, DAI Chengwei $ ^{2} $, XU Haipeng $ ^{1} $, XIONG Junlong $ ^{1} $, ZHAO Shenyang $ ^{1} $, CHANG Hongsheng $ ^{1} $ (Corresponding author)","[96, 738, 1127, 766]",frontmatter_support,0.78,"[""first-surviving-page support text: QIAO Zukang $ ^{1} $, DAI Chengwei $ ^{2} $, XU Haipeng $ ^{""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True +1,12,text," $ ^{1} $ veng $ ^{1} $, XIONG Junlong $ ^{1} $, ZHAO Shenyang $ ^{1} $, CHANG Hongsheng $ ^{1} $ (Corresponding author) + +1 Department of Medical Imaging, The First Affiliated Hospital of Zhejiang Uni","[97, 739, 1127, 825]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ veng $ ^{1} $, XIONG Junlong $ ^{1} $, ZHAO Shenyan""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,13,text,"2 The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310035, China","[96, 833, 971, 858]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2 The Third Clinical Medical College, Zhejiang Chinese Medic""]",affiliation,0.8,frontmatter_main_zone,reference_like,reference_numeric_dot,True,True +1,14,abstract,【Abstract】Objective To explore the clinical and imaging diagnostic value of MRI shoulder joint in frozen shoulder (FS). Methods A total of 30 FS patients in the frozen stage admitted to the First Affi,"[94, 863, 1131, 1264]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,15,text,【Key words】Frozen shoulder; Magnetic resonance imaging; Coracohumeral ligament; Axillary recess; Inferior glenohumeral ligaments; Diagnostic value,"[96, 1270, 1126, 1326]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,16,text,冻结肩(frozen shoulder,FS)也称粘连性肩关节囊炎,是一种以肩关节囊进行性纤维化和韧带挛缩为特点的疾病,其典型特征包括关节囊和韧带的增厚以及肩关节腔体积的减小 $ ^{[1]} $。研究显示,FS的高发年龄段在50岁左右,总体发病率为2%~5%,女性发病率略高于男性,且以左肩更常见 $ ^{[2]} $。FS的诊断主要依据临床观察到的体征和症状,主要包括肩关节的广泛疼痛和运动功能受,"[98, 1389, 597, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,17,text,,"[622, 1388, 1128, 1541]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,empty,False,True +1,18,footnote,基金项目:浙江省医药卫生科技计划项目(2023KY855);浙江省中医药科技计划项目(2024ZL422)。,"[97, 1487, 597, 1539]",footnote,0.7,"[""footnote label: \u57fa\u91d1\u9879\u76ee\uff1a\u6d59\u6c5f\u7701\u533b\u836f\u536b\u751f\u79d1\u6280\u8ba1\u5212\u9879\u76ee\uff082023KY855\uff09\uff1b\u6d59\u6c5f\u7701\u4e2d\u533b\u836f\u79d1\u6280\u8ba1\u5212\u9879\u76ee\uff082024ZL422\uff09\u3002""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True +1,19,number,4,"[100, 1568, 118, 1589]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +2,0,header,影像研究与医学应用 2025年5月 第9卷第10期,"[379, 85, 852, 110]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,1,header,论 著,"[1052, 87, 1122, 112]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +2,2,text,"情况。根据2014年国际关节镜、膝关节外科和骨科运动医学学会(International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine, ISAKOS)上肢委员会制定的标准,肩部活动受限的具体指标包括前屈活动度不足100°、外旋小于10°及内旋未能达到L5水平 $ ^{[3]} $。尽管这些标准已在临床中得","[95, 139, 601, 819]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,3,paragraph_title,1 资料与方法 1.1 一般资料,"[98, 827, 267, 883]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1 \u8d44\u6599\u4e0e\u65b9\u6cd5 1.1 \u4e00\u822c\u8d44\u6599""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,False,True +2,4,footer,,"[137, 860, 267, 883]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,empty,False,False +2,5,text,选取浙江中医药大学附属第一医院2022年8月—2023年8月收治的处于冻结期的30例FS患者作为观察组,另选取同期30名健康成人作为对照组(未报告任何肩部疼痛,且肩关节活动范围正常)。观察组男11例,女19例;年龄44~64岁,平均(53.97±5.19)岁;其中右肩患病者16例,左肩14例。对照组男11名,女19名;年龄40~66岁,平均(52.93±7.33)岁。两组的一般资料比较,差异无统计,"[95, 893, 599, 1211]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,6,text,纳入标准:(1)观察组患者符合 ISAKOS 对 FS 的诊断标准 $ ^{[3]} $;(2)年龄>18 岁;(3)观察组患者存在肩关节周围广泛性疼痛;(4)观察组患者病程超过 3 个月,处于冻结期;(5)接受肩部 MRI 检查。排除标准:(1)有肩部手术史;(2)有类风湿性关节炎病史;(3)存在全层肩袖撕裂;(4)在 6 周内接受过关节内类固醇注射;(5)合并严重基础性疾病,一般情况较差。,"[95, 1220, 599, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,7,paragraph_title,1.2 方法,"[138, 1448, 228, 1472]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.2 \u65b9\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,False,True +2,8,text,MRI 检查:采用美国 GE 3.0T Discovery MR 750 扫描仪(GE Healthcare)。患者取仰卧中立位,上肢自然伸直并置于体侧,掌心朝向躯体,拇指朝上。扫描范围为肩锁关节水平至腋窝下缘。成像方位包括横断面、斜冠状面和斜矢状面 3 个方向的 FSE T₁WI 及 T₂WI 抑脂序列,扫描层厚设置为 4.0 mm,层间距为 4.5 mm。获取矢状位和冠状位 T₂ 加权图像,其,"[95, 1481, 600, 1539]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,9,text,,"[622, 141, 1127, 394]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True +2,10,text,"将扫描获得的影像上传至影像存储和传输系统(Picture Archiving and Communication System, PACS)。为保证诊断的客观性和准确性,由2位未知诊断结果的放射科主治医师阅片,阅片者1具有5年放射诊断经验,阅片者2具有10年放射诊断经验。2位医师分别在斜矢状位 $ T_{2} $加权饱和脂肪图像上测量CHL最厚处,在斜冠状位 $ T_{2} $加权饱和脂肪图像上测","[623, 402, 1127, 656]",authors,0.8,"[""page-1 zone author_zone: \u5c06\u626b\u63cf\u83b7\u5f97\u7684\u5f71\u50cf\u4e0a\u4f20\u81f3\u5f71\u50cf\u5b58\u50a8\u548c\u4f20\u8f93\u7cfb\u7edf\uff08Picture Archiving and Communication Sys""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +2,11,paragraph_title,1.3 统计学方法,"[664, 663, 814, 687]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 1.3 \u7edf\u8ba1\u5b66\u65b9\u6cd5""]",subsection_heading,0.6,,heading_like,short_fragment,False,True +2,12,text,采用 SPSS 22.0 统计软件进行数据处理,符合正态分布的计量资料采用均数 ± 标准差 $ (\bar{x} \pm s) $ 表示,采用 t 检验;计数资料以频数(n)、百分率(%)表示,采用 $ x^{2} $ 检验。采用组内相关系数(intraclass correlation coefficient,ICC)评价观察者间信度,定量参数如下:ICC < 0.40 为较差;0.40 ≤,"[621, 696, 1129, 1081]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,13,paragraph_title,2 结果 2.1 两位阅片者测量 CHL、AR、IGHL 的一致性,"[624, 1089, 1099, 1146]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2 \u7ed3\u679c 2.1 \u4e24\u4f4d\u9605\u7247\u8005\u6d4b\u91cf CHL\u3001AR\u3001IGHL \u7684\u4e00\u81f4\u6027""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,False,True +2,14,footer,,"[663, 1121, 1099, 1146]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,empty,False,False +2,15,text,采用 Modle-“Two way Random” “Absolute Agreement” Single Measures 方法分析 ICC。ICC 值显示阅片者 1 与阅片者 2 对 CHL、AR、IGHL 的测量均为一致性优秀。见表 1。,"[622, 1155, 1127, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,16,paragraph_title,2.2 两组 CHL、AR、IGHL 厚度比较,"[664, 1252, 1000, 1276]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 2.2 \u4e24\u7ec4 CHL\u3001AR\u3001IGHL \u539a\u5ea6\u6bd4\u8f83""]",subsection_heading,0.6,,heading_like,none,False,True +2,17,text,观察组的 CHL、AR、IGHL 厚度均大于对照组,差异有统计学意义(P < 0.05)。见表 2。,"[624, 1286, 1126, 1342]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,18,paragraph_title,2.3 CHL、AR、IGHL 厚度对 FS 的诊断效能,"[663, 1350, 1067, 1374]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3 CHL\u3001AR\u3001IGHL \u539a\u5ea6\u5bf9 FS \u7684\u8bca\u65ad\u6548\u80fd""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +2,19,text,CHL 增厚诊断 FS 的截断值为 5.995 mm,灵敏度为 1.000,特异度为 0.933;AR 增厚诊断 FS 的截断值为 6.7 mm,灵敏度为 0.800,特异度为 0.933;IGHL 增厚诊断 FS 的截断值为 3.5 mm,灵敏度为 0.700,特异度为 0.967。见表 3、图 1。,"[623, 1384, 1127, 1540]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +2,20,number,5,"[1107, 1567, 1124, 1589]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +3,0,header,论 著,"[100, 87, 172, 112]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +3,1,header,影像研究与医学应用 2025年5月 第9卷第10期,"[365, 85, 838, 110]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +3,2,paragraph_title,2.4 FS 患者及健康者 CHL、AR、IGHL 影像特征及测量示意图,"[96, 140, 599, 195]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4 FS \u60a3\u8005\u53ca\u5065\u5eb7\u8005 CHL\u3001AR\u3001IGHL \u5f71\u50cf\u7279\u5f81\u53ca\u6d4b\u91cf\u793a\u610f\u56fe""]",subsection_heading,0.85,,heading_like,heading_numbered,True,True +3,3,text,病例 1:女,52 岁,临床诊断粘连性关节囊炎,斜矢状位 T₂WI FSE 脂肪抑制序列 MR 显示 CHL、AR、IGHL 均增厚(白色箭头,图 2a、3a、4a);病例 2,男,46 岁,健康人,斜矢状位 T₂WI FSE 脂肪抑制序列 MRI 显示 CHL、AR、IGHL 未见增厚(白色箭头,图 2b、3b、4b);图 2c、3c、4c 分别为 CHL、AR、IGHL 测量示意图。,"[95, 201, 602, 410]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +3,4,figure_title,表 1 2 位阅片者的 ICC 评估,"[242, 446, 454, 466]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 1 2 \u4f4d\u9605\u7247\u8005\u7684 ICC \u8bc4\u4f30""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +3,5,table,
指标ICC95%CI
CHL0.9890.977 ~ 0.994
AR0.9380.898 ~ 0.962
IGHL0.995
组别例数CHLARIGHL
观察组30$ 7.85 \pm 1.49 $$ 9.10 \pm 3.71 $$ 5.22 \pm 3.17 $
对照,"[99, 637, 595, 768]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +3,8,figure_title,表 3 CHL、AR、IGHL 增厚对 FS 的诊断效能,"[707, 142, 1044, 162]",figure_caption_candidate,0.85,"[""figure_title label: \u8868 3 CHL\u3001AR\u3001IGHL \u589e\u539a\u5bf9 FS \u7684\u8bca\u65ad\u6548\u80fd""]",figure_caption,0.85,,legend_like,none,False,False +3,9,table,<,"[625, 166, 1124, 271]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +3,10,chart,,"[632, 322, 1024, 710]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +3,11,figure_title,图 1 CHL、AR、IGHL 增厚诊断 FS 的 ROC 曲线,"[693, 751, 1057, 773]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 1 CHL\u3001AR\u3001IGHL \u589e\u539a\u8bca\u65ad FS \u7684 ROC \u66f2\u7ebf""]",figure_caption,0.85,,legend_like,none,False,False +3,12,image,,"[238, 823, 482, 1068]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,13,figure_title,(a),"[344, 1085, 372, 1104]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,14,image,,"[490, 824, 738, 1068]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,15,figure_title,(b),"[606, 1085, 633, 1103]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,16,image,,"[765, 843, 969, 1051]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,17,figure_title,(c),"[852, 1085, 881, 1104]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,18,figure_title,"注:(a)CHL 增厚(箭头);(b)CHL 未见增厚(箭头);(c)CHL 测量示意(箭头)。 +图 2 FS 患者及健康人 CHL 影像特征及测量示意图","[129, 1112, 795, 1164]",figure_caption_candidate,0.85,"[""figure_title label: \u6ce8\uff1a\uff08a\uff09CHL \u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08b\uff09CHL \u672a\u89c1\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08c\uff09CHL \u6d4b\u91cf\u793a\u610f\uff08\u7bad\u5934\uff09\u3002\n\u56fe 2 FS \u60a3\u8005\u53ca\u5065""]",figure_caption,0.85,,legend_like,none,False,False +3,19,image,,"[238, 1198, 483, 1446]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,20,figure_title,(a),"[344, 1459, 372, 1475]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,21,image,,"[490, 1199, 739, 1446]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,22,figure_title,注:(a)AR 增厚(箭头);(b)AR 未见增厚(箭头);(c)AR 测量示意(箭头)。,"[129, 1487, 750, 1506]",figure_caption_candidate,0.85,"[""figure_title label: \u6ce8\uff1a\uff08a\uff09AR \u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08b\uff09AR \u672a\u89c1\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08c\uff09AR \u6d4b\u91cf\u793a\u610f\uff08\u7bad\u5934\uff09\u3002""]",figure_caption,0.85,,legend_like,none,False,False +3,23,figure_title,(b),"[599, 1457, 626, 1475]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,24,image,,"[772, 1235, 947, 1443]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +3,25,figure_title,(c),"[853, 1457, 881, 1476]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,26,figure_title,图 3 FS 患者及健康人 AR 影像特征及测量示意图,"[435, 1516, 789, 1538]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 3 FS \u60a3\u8005\u53ca\u5065\u5eb7\u4eba AR \u5f71\u50cf\u7279\u5f81\u53ca\u6d4b\u91cf\u793a\u610f\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +3,27,number,6,"[100, 1568, 117, 1589]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +4,0,header,影像研究与医学应用 2025年5月 第9卷第10期,"[379, 85, 852, 110]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +4,1,header,论 著,"[1052, 87, 1122, 112]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +4,2,image,,"[227, 142, 477, 391]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +4,3,figure_title,(a),"[343, 403, 373, 422]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,4,image,,"[486, 142, 741, 391]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +4,5,image,,"[779, 179, 957, 391]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +4,6,figure_title,(b),"[605, 402, 633, 421]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,7,figure_title,注:(a)IGHL增厚(箭头);(b)IGHL未见增厚(箭头);(c)IGHL测量示意(箭头)。,"[129, 428, 795, 449]",figure_caption_candidate,0.85,"[""figure_title label: \u6ce8\uff1a\uff08a\uff09IGHL\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08b\uff09IGHL\u672a\u89c1\u589e\u539a\uff08\u7bad\u5934\uff09\uff1b\uff08c\uff09IGHL\u6d4b\u91cf\u793a\u610f\uff08\u7bad\u5934\uff09\u3002""]",figure_caption,0.85,,legend_like,none,False,False +4,8,figure_title,(c),"[852, 403, 881, 422]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +4,9,figure_title,图 4 FS 患者及健康人 IGHL 影像特征及测量示意图,"[427, 456, 798, 477]",figure_caption_candidate,0.85,"[""figure_title label: \u56fe 4 FS \u60a3\u8005\u53ca\u5065\u5eb7\u4eba IGHL \u5f71\u50cf\u7279\u5f81\u53ca\u6d4b\u91cf\u793a\u610f\u56fe""]",figure_caption,0.85,,legend_like,none,False,False +4,10,paragraph_title,3 讨论,"[96, 513, 177, 538]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3 \u8ba8\u8bba""]",subsection_heading,0.6,reference_zone,reference_like,reference_numeric_dot,False,True +4,11,text,FS 是一种常见的临床疾病,传统上被认为是一种自限性疾病,通常能够自行缓解。然而,近期的研究表明,41% 的 FS 患者在疾病发生 4 年后仍然遭受轻度至中度的症状困扰,其中 6% 的患者甚至出现严重的疼痛和功能丧失 $ ^{[11]} $。这一发现凸显了及时的临床诊断和治疗对于 FS 恢复的重要性。,"[95, 545, 599, 726]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,12,text,尽管目前对 FS 的具体病理机制尚不完全清楚 $ ^{[12]} $,且缺乏统一的客观诊断标准,FS 的诊断仍然主要依赖于临床检查。这种情况为实现 FS 的精准治疗带来了挑战。有研究开始利用 MRI 作为诊断 FS 的辅助手段 $ ^{[13]} $。根据关节镜和组织学观察,FS 的病理变化可分为 3 个阶段:Ⅰ期以炎症性滑膜反应为主,尚未形成粘连;Ⅱ期粘连开始形成,伴有血管性滑膜炎和 AR 折叠,"[95, 730, 598, 1102]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,13,text,本研究中,2名放射科医师独立测量所得的平均 ICC 分别为 0.989、0.938、0.995,表明测量结果具有极强的一致性和高度的可重复性。通过阅片者 2 的测量结果进一步证实了 FS 患者中 CHL、AR 和 IGHL 的厚度较正常人明显增厚,与相关研究结果相似 $ ^{[16-17]} $。近年来的 MRI 研究一致表明,肩关节囊及周围韧带的增厚,特别是 CHL、IGHL 和 AR,是诊断 ,"[95, 1107, 600, 1541]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,14,text,,"[620, 511, 1127, 1259]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True +4,15,text,尽管 FS 患者在多个运动平面上的肩关节活动度均受到不同程度的影响,但主要以外旋、前屈和外展受限为主 $ ^{[5]} $。根据解剖学原理,CHL、AR 和 IGHL 是限制肩关节外展和外旋的关键结构。因此,CHL、AR 和 IGHL 的增厚可能是导致 FS 患者肩关节活动受限的主要原因,为临床诊断 FS 提供重要的参考依据。此外,Lin 等 $ ^{[25]} $的研究进一步证实减小 CHL 和,"[622, 1263, 1128, 1541]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +4,16,number,7,"[1107, 1567, 1125, 1589]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +5,0,header,论 著,"[100, 87, 171, 112]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +5,1,header,影像研究与医学应用 2025年5月 第9卷第10期,"[366, 85, 837, 110]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +5,2,text,可能有助于恢复 FS 患者的肩关节功能,提高患者的生活质量。,"[98, 139, 597, 198]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +5,3,text,综上所述,CHL、AR 和 IGHL 的增厚是 FS 的典型形态学特征。在斜矢状位上,CHL 的显示效果最佳,而在斜冠状位上则有利于展示 IGHL 和 AR 的解剖结构。特别是 CHL 的增厚,不仅具有高灵敏度和特异度,而且在 MRI 上易于识别,有望成为早期准确诊断、治疗 FS 的可靠依据。,"[96, 206, 599, 396]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,unknown_like,none,True,True +5,4,paragraph_title,【参考文献】,"[106, 435, 217, 459]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: \u3010\u53c2\u8003\u6587\u732e\u3011""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +5,5,reference_content,"[1] CHALLOUMAS D, BIDDLE M, MCLEAN M, et al. Comparison of treatments for frozen shoulder: a systematic review and meta-analysis [J]. JAMA Netw Open, 2020, 3(12): e2029581.","[103, 469, 598, 554]",reference_item,0.85,"[""reference content label: [1] CHALLOUMAS D, BIDDLE M, MCLEAN M, et al. Comparison of t""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,6,reference_content,"[2] TAMAI K, HAMADA J, NAGASE Y, et al. Frozen shoulder. An overview of pathology and biology with hopes to novel drug therapies [J]. Mod Rheumatol, 2024, 34(3): 439-443.","[103, 567, 598, 652]",reference_item,0.85,"[""reference content label: [2] TAMAI K, HAMADA J, NAGASE Y, et al. Frozen shoulder. An ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,7,reference_content,"[3] ITOI E, ARCE G, BAIN G I, et al. Shoulder stiffness: current concepts and concerns [J]. 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Optimal Cut-Off Valu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,25,reference_content,"[20] XIANG J, ZHOU X, LIU Y, et al. Magnetic resonance imaging features for diagnosing adhesive capsulitis of the shoulder: a systematic review and meta-analysis [J]. BMC Musculoskelet Disord, 2025, 2","[631, 863, 1125, 948]",reference_item,0.85,"[""reference content label: [20] XIANG J, ZHOU X, LIU Y, et al. Magnetic resonance imagi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,26,reference_content,"[21] DUPONT T, IDIR M A, HOSSU G, et al. MR imaging signs of shoulder adhesive capsulitis: analysis of potential differentials and improved diagnostic criteria [J]. Skeletal Radiol, 2025, 54(1): 77–86","[631, 961, 1125, 1047]",reference_item,0.85,"[""reference content label: [21] DUPONT T, IDIR M A, HOSSU G, et al. MR imaging signs of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,27,reference_content,"[22] ARAI R, NIMURA A, YAMAGUCHI K, et al. The anatomy of the coracohumeral ligament and its relation to the subscapularis muscle [J]. J Shoulder Elbow Surg, 2014, 23(10): 1575–1581.","[628, 1059, 1126, 1144]",reference_item,0.85,"[""reference content label: [22] ARAI R, NIMURA A, YAMAGUCHI K, et al. The anatomy of th""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,28,reference_content,"[23] UNERFÜBER L, SCHWARZ G M, HIRTLER L. Association of damage to the coracohumeral ligament with anterosuperior rotator cuff degeneration revealed by anatomical dissection [J]. Sci Rep, 2022, 12(1):","[629, 1158, 1126, 1274]",reference_item,0.85,"[""reference content label: [23] UNERF\u00dcBER L, SCHWARZ G M, HIRTLER L. Association of dam""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,29,reference_content,"[24] VAN SPANNING S H, LAFOSSE T, VERWEIJ LPE, et al. Predictive value of Gagey's hyperabduction test in identifying inferior glenohumeral ligament lesions [J]. Orthop Traumatol Surg Res, 2023, 109(4)","[631, 1288, 1125, 1405]",reference_item,0.85,"[""reference content label: [24] VAN SPANNING S H, LAFOSSE T, VERWEIJ LPE, et al. Predic""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,30,reference_content,"[25] LIN P, YANG M D, HUANG D Q, et al. Effect of proprioceptive neuromuscular facilitation technique on the treatment of frozen shoulder: a pilot randomized controlled trial [J]. BMC Musculoskelet Di","[633, 1420, 1126, 1535]",reference_item,0.85,"[""reference content label: [25] LIN P, YANG M D, HUANG D Q, et al. Effect of propriocep""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +5,31,number,8,"[100, 1568, 117, 1588]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/5DIEAVPW/block_trace.csv b/tests/fixtures/ocr_real_papers/5DIEAVPW/block_trace.csv new file mode 100644 index 00000000..245d03ef --- /dev/null +++ b/tests/fixtures/ocr_real_papers/5DIEAVPW/block_trace.csv @@ -0,0 +1,208 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,Lee et al. Knee Surgery & Related Research (2022) 34:1 https://doi.org/10.1186/s43019-022-00132-8,"[108, 63, 488, 106]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +1,1,header,Knee Surgery & Related Research,"[850, 64, 1082, 123]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,text,REVIEW ARTICLE,"[120, 181, 343, 209]",authors,0.6,"[""page-1 initial-lastname author byline: REVIEW ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,3,text,Open Access,"[923, 180, 1075, 208]",frontmatter_noise,0.7,"[""frontmatter noise text: Open Access""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,image,,"[1019, 221, 1077, 278]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,5,doc_title,"Past, present, and future of cartilage restoration: from localized defect to arthritis","[108, 238, 993, 337]",paper_title,0.8,"[""page-1 zone title_zone: Past, present, and future of cartilage restoration: from loc""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text,"Dong Hwan Lee, Seok Jung Kim $ ^{*} $, Seon Ae Kim and Gang-ik Ju","[107, 356, 658, 385]",authors,0.8,"[""page-1 zone author_zone: Dong Hwan Lee, Seok Jung Kim $ ^{*} $, Seon Ae Kim and Gang-""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,paragraph_title,Abstract,"[122, 454, 209, 479]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True +1,8,abstract,"Background: Osteoarthritis, one of the most common joint diseases, is characterized by the loss of joint function due to articular cartilage destruction. Herein, we review current and previous researc","[120, 485, 1051, 559]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,9,abstract,"Past, present, and future treatment: The arthroscopic cartilage regeneration procedure or realignment osteotomy has been performed as a joint-conserving procedure in cases where conservative treatment","[120, 564, 1065, 756]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,abstract,"Conclusion: Currently, arthritis management primarily involves the surgical application of therapeutic agents to the joints. However, nonsurgical or prophylactic methods are expected to become mainstr","[119, 762, 1058, 835]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,11,text,"Keywords: Minimally invasive surgery, Osteoarthritis, Arthritis, Biological treatment","[119, 840, 794, 866]",structured_insert,0.7,"[""keyword-like block: Keywords: Minimally invasive surgery, Osteoarthritis, Arthri""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,12,paragraph_title,Background,"[109, 910, 228, 932]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Background""]",section_heading,0.5,body_zone,heading_like,short_fragment,True,True +1,13,text,"Although mechanistic details regarding outcomes associated with articular cartilage damage remain unclear, the idea that arthritis occurs in areas surrounding articular cartilage damage is generally a","[106, 935, 585, 1176]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Although mechanistic details regarding outcomes associated w""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,14,text,"contributes to additional medical problems [3]. Pain +management using medication and physical treatment +have long been therapeutic options for the treatment of +damaged articular cartilage and early ar","[602, 909, 1083, 1125]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,15,text,"As life expectancy increases, patients have tended to have an increasingly strong desire to live a healthy life and maintain their native joints into old age. Therefore, efforts to protect articular c","[602, 1126, 1082, 1271]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,footnote,*Correspondence: peter@catholic.ac.kr,"[109, 1209, 351, 1229]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: *Correspondence: peter@catholic.ac.kr""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,17,footnote,"Department of Orthopedic Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271, Cheonbo-ro, Gyeonggi-do 11765 Uijeongbu-si, Republic of Korea","[108, 1219, 541, 1284]",footnote,0.7,"[""footnote label: Department of Orthopedic Surgery, Uijeongbu St. Mary's Hospi""]",footnote,0.7,body_zone,body_like,none,True,True +1,18,footer_image,,"[115, 1315, 323, 1401]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True +1,19,footer,"© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any ","[354, 1316, 1075, 1447]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False +2,0,header,Lee et al. Knee Surgery & Related Research (2022) 34:1,"[108, 63, 490, 85]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,1,number,Page 2 of 8,"[1001, 64, 1082, 86]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,text,"cartilage and arthritis. Recently, efforts have been made to preserve joints using nonsurgical methods [7]. Herein, we intend to review past and present research that has examined the clinical applica","[106, 173, 586, 297]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,paragraph_title,Past,"[107, 317, 159, 340]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Past""]",sub_subsection_heading,0.6,frontmatter_side_zone,heading_like,short_fragment,True,True +2,4,text,"In 1934, Burman was the first to release a report on arthroscopic treatment using the word “arthroscopy” in the title [8]. His findings revealed that patients with arthritis experienced symptom improv","[106, 342, 586, 535]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"About two decades later, in 1959, Pridie introduced the principle of drilling exposed subchondral bone to treat damaged cartilage [9]. The objective of the procedure was to form fibrocartilage by allo","[107, 534, 586, 967]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"Multiple reports have shown that microfracture may be used to effectively treat local cartilage defects in young patients. Recently, it has become a basic surgical technique in the treatment of local ","[107, 966, 586, 1017]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"patients. Recently, it has become a basic surgical tech- +nique in the treatment of local cartilage defects [14, 15]. +However, after microfracture surgery, the structure of +subchondral bones can weaken","[602, 174, 1083, 367]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,text,"Microfracture treatment involves the creation of a channel in the subchondral bone to allow bone marrow components, including bone marrow mesenchymal stem cells, to flow outward. This allows stem cell","[602, 365, 1084, 1019]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,image,,"[206, 1079, 984, 1415]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,10,figure_title,"Fig. 1 Images of cartilage defects with multiple sites of drilling a at the time of surgery, and b via arthroscopy 2-years postsurgery are shown","[119, 1423, 1026, 1444]",figure_caption,0.92,"[""figure_title label: Fig. 1 Images of cartilage defects with multiple sites of dr""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,0,header,Lee et al. Knee Surgery & Related Research (2022) 34:1,"[108, 63, 489, 85]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +3,1,number,Page 3 of 8,"[1001, 64, 1082, 86]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,microfracture has emerged as an initial treatment for femoral cartilage damage in the knee joint (Fig. 2).,"[106, 174, 584, 222]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,"Lanny Johnson introduced abrasion arthroplasty at the American Academy of Orthopedic Surgeons (AAOS) in 1982, where he reported that two thirds of 103 patients who underwent the therapy obtained satis","[107, 222, 586, 895]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,"In the past, joint problems in patients with arthritis were mainly treated because there were limited strategies for objectively measuring and diagnosing articular cartilage damage. In fact, the metho","[106, 894, 586, 1042]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,"joint problems. Studies revealed that MRI could be used +to identify articular cartilage damage as the cause of joint +problems [30].","[602, 173, 1082, 248]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,Present,"[604, 269, 685, 292]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Present""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +3,7,text,The most important changes that facilitated the shift from past to present treatment strategies were the efforts made to overcome limitations due to the histological characteristics of articular carti,"[602, 294, 1084, 630]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"After autologous chondrocyte implantation (ACI) was first performed by Brittberg [34] in 1994, cartilage treatment using cells was developed rapidly. To perform the procedure, a small amount (200–300 ","[602, 630, 1083, 870]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"First-generation ACI was developed and used by Britt-berg [35]. In first-generation ACI, a cartilage defect is covered with a periosteal flap taken from the proximal medial tibia. Then, chondrocytes a","[602, 870, 1083, 1041]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,image,,"[169, 1102, 1024, 1395]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,11,figure_title,"Fig. 2 Images of a cartilage defect of the medial femoral condyle a, b after microfracture was performed, and c at 1-year follow-up via magnetic resonance imaging are shown. The yellow arrow indicates","[119, 1403, 1047, 1444]",figure_caption,0.92,"[""figure_title label: Fig. 2 Images of a cartilage defect of the medial femoral co""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,0,header,Lee et al. Knee Surgery & Related Research (2022) 34:1,"[108, 63, 490, 86]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +4,1,number,Page 4 of 8,"[1001, 64, 1082, 87]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,text,"involves the collection of the periosteal flap and tight suturing to prevent cultured chondrocyte leakage. Further, issues may occur due to a large incision or the dedifferentiation and calcification ","[106, 171, 585, 292]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"Second-generation ACI involves the seeding of chondrocytes in a bioscaffold, such as a collagen membrane or fibrin glue, for culture and mixing. They are then implanted within the defect area [39, 40]","[106, 293, 586, 509]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,text,Third-generation ACI is performed by implanting cell pellets within the area of the cartilage defect via a specialized culture technique that does not involve use of a bioscaffold. This technique incr,"[106, 508, 586, 677]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) have been approved for use with medical products. Various clinical findings associated with hUCB-MSC use have been reported [45, 46","[107, 675, 587, 1136]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"compared with other cells [49]. Since there is a great +probability that they may be used for allogenic stem cell +therapy, commercial products containing umbilical cord +stem cells have been developed [","[602, 172, 1082, 268]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,CARTISTEM is an hUCB-MSC product approved for the treatment of osteoarthritis. Recent studies shown that favorable outcomes are achievable (Table 1) including clinical score improvement throughout 1–7,"[602, 269, 1084, 628]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"Although ACI or stem cell procedures produce good results [55], single-stage operations that use bioscaffolds or isolated cells from the bone marrow [56, 57] or fat [58] have become popular due to the","[602, 628, 1083, 917]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,Autologous matrix-induced chondrogenesis (AMIC) is a surgical technique that was developed to enhance arthroscopic microfracture. The procedure is performed as follows: curettage is performed on the c,"[601, 916, 1083, 1136]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,figure_title,Table 1 Summary of the literature evaluating the use of hUCB-MSC,"[108, 1194, 605, 1217]",table_caption,0.9,"[""table prefix matched: Table 1 Summary of the literature evaluating the use of hUCB""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,11,table,
指标AUCP95%CI截断值灵敏度特异度
CHL0.990< 0.0010.973~1.0005.995 mm1.000
Patients (n)Follow-up (years)StagingClinical scoreImaging and second lookKey features of the study
Park et al.
Piezoelectric biomaterials and their applications in cartilage regenulation.
TypesMaterialsMorphology DesignDimensionSyn","[69, 121, 1121, 1450]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,vision_footnote,(continued on next page),"[967, 1438, 1107, 1457]",footnote,0.7,"[""vision_footnote label: (continued on next page)""]",footnote,0.7,body_zone,body_like,none,True,True +6,5,number,6,"[589, 1515, 602, 1529]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Y. Wei et al.,"[71, 69, 146, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,1,header,Ultrasonics Sonochemistry 117 (2025) 107353,"[859, 69, 1120, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,figure_title,Table 1 (continued),"[71, 107, 204, 127]",table_caption,0.9,"[""table prefix matched: Table 1 (continued)""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +7,3,table,
TypesMaterialsMorphology DesignDimensionSynthesis RouteWorking ConditionPiezoelectric CoefficientRef.
PropertyBoneCartilage
Main cell populations responsive to PEMFOsteoblasts, MSCs, osteoclastsChondrocytes, chondroprogenitor cells, M","[97, 184, 1092, 464]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +4,4,text,"The dielectric and piezoelectric features of natural bone, responsible for the bioelectric signaling occurring within the tissue regulating its remodeling and homeostasis, have been previously demonst","[92, 517, 586, 995]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"The primary origin of bone piezoelectricity arises from the noncentrosymmetric structure of COL1 fibers that, upon mechanical stimulation, slide over each other, creating a separation and polarization","[92, 996, 587, 1404]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,2.2 Articular cartilage,"[94, 1446, 339, 1474]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2 Articular cartilage""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,7,text,Articular cartilage is a highly specialized and complex connective tissue consisting in chondrocytes embedded in a dense ECM mainly composed by collagen type II (COL2) fibrils intertwined with proteog,"[93, 1499, 586, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,,"[602, 517, 1097, 971]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,9,text,"Articular cartilage tissue has been shown to regulate its own metabolism through physical phenomena, namely, through physical interactions (electrical or mechanical signals) between the resident cells","[602, 974, 1097, 1235]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,"The electrical properties of the cartilage tissue arise from the flow of free cations—such as K⁺, Ca²⁺, and Na⁺—interacting with the fixed negative charges present on the carboxyl and sulfate groups a","[602, 1237, 1098, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,footer,Frontiers in Bioengineering and Biotechnology,"[94, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,12,number,04,"[584, 1600, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,13,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,Masante et al.,"[95, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,image,,"[101, 165, 1070, 735]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +5,3,figure_title,"(A) Schematic representation of a general PEMF stimulator, composed of a single coil or a pair of Helmholtz's coils; (B) Example of PEMF stimulation of 2D in vitro culture with custom-made device. Rep","[115, 756, 1071, 875]",figure_caption,0.85,"[""figure_title label: (A) Schematic representation of a general PEMF stimulator, c""]",figure_caption,0.85,,support_like,none,True,True +5,4,text,"properties (Denning et al., 2014). Notably, as in bone, the piezoelectricity of cartilage is crucial for the tissue's maintenance and function. When cartilage is exposed to mechanical stress, the endo","[92, 921, 586, 1090]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,paragraph_title,3 PEMF stimulators,"[94, 1130, 342, 1158]",section_heading,0.85,"[""paragraph_title label with numbering: 3 PEMF stimulators""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +5,6,text,"Several PEMF stimulators, both commercially available and custom-made, were used in the reported studies. In general, a PEMF device consists of a power supply connected to a single solenoid or a pair ","[92, 1184, 587, 1543]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,,"[602, 920, 1097, 1279]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +5,8,paragraph_title,4 Quantitative descriptor for comparing PEMF stimulation protocols,"[603, 1322, 1094, 1376]",section_heading,0.85,"[""paragraph_title label with numbering: 4 Quantitative descriptor for comparing PEMF stimulation pro""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +5,9,text,"To address the challenge of comparing PEMF stimulation protocols and biological outcomes obtained using different PEMF stimulators and applying different operating parameters, we propose the use of a ","[602, 1399, 1097, 1543]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,11,number,05,"[584, 1599, 606, 1617]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,12,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Masante et al.,"[96, 68, 191, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1094, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,2,figure_title,TABLE 2 Commercially available PEMF stimulators and operating parameters.,"[95, 160, 611, 180]",table_caption,0.9,"[""table prefix matched: TABLE 2 Commercially available PEMF stimulators and operatin""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,3,table,"
Device's nameCompany, countryWaveformMagnetic field intensity (B)Frequency (f)Pulse time (t)TunabilityReferences of s","[97, 181, 1093, 1094]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +6,4,text,"waveform, and the exposure duration to the magnetic field. In detail, we calculated the PEMF dose (D), expressed in mT·h, as in Equation 1:","[94, 1124, 585, 1195]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,display_formula, $$ D=B_{r m s}\cdot t_{e x p} $$ ,"[282, 1213, 398, 1235]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +6,6,formula_number,(1),"[559, 1212, 582, 1233]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,7,text,"where $ B_{rms} $ is the root mean square value of the magnetic field intensity (in mT), and $ t_{exp} $ is the total exposure duration (in h) to the PEMF stimulation. For the different stimulation ","[92, 1256, 585, 1470]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,The $ t_{exp} $ was calculated as in Equation 2:,"[121, 1473, 430, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,display_formula," $$ t_{\mathrm{e x p}}=E D_{d a y}\cdot E D_{w e e k}\cdot n_{w e e k}, $$ ","[228, 1512, 450, 1535]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +6,10,formula_number,(2),"[559, 1511, 582, 1532]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,11,figure_title,"TABLE 3 Formulas adopted for the calculation of $ B_{rms} $ depending on the waveform. $ B_{peak} $ is the peak intensity of the PEMF waveform, DC is the waveform duty cycle.","[604, 1125, 1089, 1173]",table_caption,0.9,"[""table prefix matched: TABLE 3 Formulas adopted for the calculation of $ B_{rms} $""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,12,table,
PEMF waveform$ B_{rms} $
Square$ B_{rms} = B_{peak} \cdot \sqrt{DC} $
Triangular$ B_{rms} = \frac{B_{peak}}{\sqrt{3}} \cdot ,"[605, 1180, 1092, 1416]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,13,text,"where $ ED_{day} $ is the daily exposure duration to the PEMF stimulation (h/day), $ ED_{week} $ is the number of days of the week in which PEMF stimulation is applied (day/week), and $ n_{week} $ ","[603, 1441, 1096, 1537]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,14,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1599, 403, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,15,number,06,"[584, 1599, 607, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,16,footer,frontiersin.org,"[998, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1094, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,chart,,"[235, 179, 956, 604]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,3,figure_title,"Log-log graph of the root mean square value of the magnetic field intensity ( $ B_{rms} $) versus the total exposure duration ( $ t_{exp} $), showing isolines of constant PEMF dose (D) and the procedu","[119, 630, 1040, 672]",figure_caption,0.85,"[""figure_title label: Log-log graph of the root mean square value of the magnetic ""]",figure_caption,0.85,body_zone,legend_like,none,True,True +7,4,text,"In Sections 5, 6, the PEMF dose has been calculated only for the studies that provided all the parameters needed for the evaluation ( $ B_{peak} $ waveform, DC, $ t_{exp} $) while excluding the studi","[91, 735, 585, 998]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"In addition, for visually representing and using the PEMF dose descriptor, we propose a log-log graph of $ B_{rms} $ versus $ t_{exp} $ where isolines of constant D values appear as straight lines (","[92, 1000, 586, 1287]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,paragraph_title,5 In vitro PEMF studies,"[94, 1328, 387, 1356]",section_heading,0.85,"[""paragraph_title label with numbering: 5 In vitro PEMF studies""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +7,7,text,"Over the past few decades, numerous in vitro experiments have been conducted on bone and cartilage cells, as well as on 3D tissue models, to investigate the effects of PEMF stimulation and the associa","[92, 1382, 586, 1525]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,5.1 Bone,"[606, 732, 709, 759]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1 Bone""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,9,text,"For investigating the effects of PEMF stimulation on bone stem cells, differentiated cells, or even 3D constructs, the literature reports a wide range of values for each PEMF stimulation parameter. In","[603, 785, 1096, 951]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,"Several researchers adopted a specific PEMF parameter combination (B = 1.5 mT, f = 75 Hz, t = 1.3 ms, and a quasi-triangular waveform), which can be obtained using the commercially available PEMF stim","[603, 953, 1098, 1525]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 403, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,12,number,07,"[585, 1599, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,13,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Masante et al.,"[95, 68, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,2,figure_title,TABLE 4 In vitro studies on the effects of PEMF stimulation on bone tissue.,"[95, 160, 600, 180]",table_caption,0.9,"[""table prefix matched: TABLE 4 In vitro studies on the effects of PEMF stimulation ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +8,3,table,
ReferenceCell origin and typePEMF stimulatorPEMF waveformPEMF parametersPEMF exposure durationMain biological outcomes/Signaling pa,"[96, 183, 1093, 1481]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +8,4,vision_footnote,(Continued on following page),"[912, 1485, 1094, 1505]",footnote,0.7,"[""vision_footnote label: (Continued on following page)""]",footnote,0.7,body_zone,body_like,none,True,True +8,5,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,6,number,08,"[584, 1599, 607, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,7,footer,frontiersin.org,"[998, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,Masante et al.,"[96, 68, 191, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,1,header,10.3389/fbioe.2025.1557572,"[907, 68, 1095, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,2,figure_title,TABLE 4 (Continued) In vitro studies on the effects of PEMF stimulation on bone tissue.,"[94, 158, 681, 177]",table_caption,0.9,"[""table prefix matched: TABLE 4 (Continued) In vitro studies on the effects of PEMF ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,3,table,
ReferenceCell origin and typePEMF stimulatorPEMF waveformPEMF parametersPEMF exposure durationMain biological outcomes/Signaling pa,"[97, 175, 1093, 1169]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +9,4,text,"involved in osteogenic differentiation, and increased microRNA and the vascular endothelial growth factor (VEGF) expression, which are both essential for promoting osteogenesis and angiogenesis (Baghe","[92, 1211, 587, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,text,,"[602, 1211, 1099, 1546]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +9,6,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1599, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,7,number,09,"[584, 1600, 607, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,8,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,2,text,"Besides the differentiation of hBMMSCs toward osteoblasts, it was also demonstrated that imposing a specific PEMF stimulation (B = 3 mT, f = 15 Hz, triangular waveform) may reduce osteoclastic differe","[92, 160, 586, 638]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,3,text,"Interestingly, Zhou and colleagues demonstrated that cell proliferation can be affected by PEMF stimulation by varying the waveform type. Imposing a specific PEMF stimulation protocol ( $ B_{rms} = 1.","[92, 639, 586, 996]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,"In summary, although the high variability in operating parameters, it is interesting to note that PEMF stimulation applied on bone stem cells generally induces osteogenic differentiation, which is ass","[92, 998, 586, 1548]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,,"[603, 161, 1097, 425]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,6,paragraph_title,5.2 Quantitative comparison among in vitro studies on PEMF stimulation for bone tissue,"[603, 468, 1096, 517]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2 Quantitative comparison among in vitro studies on PEMF s""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +10,7,text,Figure 3 shows the distribution of the root mean square values of the magnetic field intensity $ (B_{\mathrm{rms}}) $ and the PEMF dose $ (D) $ values (in logarithmic scale) for some of the in vitro,"[603, 543, 1096, 731]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 3 shows the distribution of the root mean square valu""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +10,8,text,"Interestingly, in studies where the applied $ B_{rms} $ was below 0.3 mT and the resulting D value was less than 10 mT•h (grey rectangle in Figure 3), a delay in ALP expression or even no ALP express","[601, 732, 1097, 1376]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,9,text,"Remarkably, for $ B_{rms} $ values above 0.3 mT, intensity-dependent effects could not be observed, but from the literature studies analyzed it appears that a minimum value of PEMF dose should be del","[603, 1379, 1095, 1548]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 403, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,11,number,10,"[585, 1599, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,12,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,2,chart,,"[210, 178, 981, 718]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +11,3,figure_title,Distribution of the root mean square value of the magnetic field intensity ( $ B_{rms} $) and the PEMF dose (D) value for the in vitro studies performed imposing PEMF stimulation on bone cells/tissues,"[116, 743, 1053, 806]",figure_caption,0.85,"[""figure_title label: Distribution of the root mean square value of the magnetic f""]",figure_caption,0.85,body_zone,legend_like,none,True,True +11,4,text,"(corresponding to $D = 0.11$ mT•h) did not show any significant differences in comparison to the untreated group. Differently, the experimental groups subjected to longer exposure durations, thus rece","[91, 876, 586, 1378]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"To sum up, the proposed quantitative comparison made it possible to deduce that, for low $ B_{rms} $ values (<0.3 mT), the exposure duration plays a crucial role, as enhanced osteogenic differentiati","[92, 1381, 585, 1545]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,,"[603, 876, 1095, 923]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +11,7,paragraph_title,5.3 Cartilage,"[605, 969, 753, 995]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3 Cartilage""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +11,8,text,"PEMF stimulation has recently gained attention also as a promising non-invasive treatment for enhancing the clinical outcome of cartilage repair procedures, showing both anti-inflammatory and chondrog","[602, 1023, 1097, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 403, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,10,number,11,"[585, 1600, 604, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,11,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,header,Masante et al.,"[95, 68, 192, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,2,figure_title,TABLE 5 In vitro studies on the effects of PEMF stimulation on cartilage tissue.,"[95, 160, 623, 180]",table_caption,0.9,"[""table prefix matched: TABLE 5 In vitro studies on the effects of PEMF stimulation ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +12,3,table,
ReferenceCell origin and typePEMF stimulatorPEMF waveformPEMF parametersPEMF exposure durationMain biological outcomes/ Signaling p,"[96, 182, 1092, 1317]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +12,4,text,"(day) applied to human umbilical cord derived MSCs was observed to significantly enhance COL2 expression, with no differences between the devices utilized (Esposito et al., 2013). Differently, stimula","[92, 1355, 587, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,,"[602, 1356, 1098, 1546]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +12,6,footer,Frontiers in Bioengineering and Biotechnology,"[94, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,7,number,12,"[585, 1599, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,8,footer,frontiersin.org,"[997, 1599, 1095, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,2,text,"2 mT, f = 15 Hz, sinusoidal waveform) to chondroprogenitors harvested from non-diseased human knee joints for 10 min every 3 days over a period of 21 days did not result in any significant increase in","[93, 161, 585, 853]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +13,3,text,"Briefly, several studies demonstrated that PEMF may have beneficial influence for cartilage regeneration, particularly promoting the differentiation of stem cells towards chondrocytes, enhancing the e","[93, 853, 585, 999]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,paragraph_title,5.4 Quantitative comparison among in vitro studies on PEMF stimulation for cartilage tissue,"[94, 1040, 584, 1116]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.4 Quantitative comparison among in vitro studies on PEMF s""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +13,5,text,"Similarly to what was reported for the in vitro studies on bone cells, the wide PEMF parameter variation that characterize the in vitro studies for cartilage tissue results in $ B_{rms} $ values rang","[91, 1141, 585, 1548]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,6,text,,"[603, 161, 1096, 278]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +13,7,text,"In contrast, for $D$ values below 3.5 mT•h, no clear relationship between PEMF parameters and biological effects could be established. Recently, hBMMSCs were exposed to square PEMF waveform varying th","[603, 281, 1096, 636]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,8,text,"Overall, the quantitative comparison of in vitro studies applying PEMF stimulation to cartilage cells indicates that the exposure duration might be a crucial parameter, indeed increased chondrocyte pr","[603, 639, 1097, 830]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,9,paragraph_title,6 In vivo animal studies,"[606, 872, 906, 900]",section_heading,0.85,"[""paragraph_title label with numbering: 6 In vivo animal studies""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +13,10,text,"The effects of PEMF stimulation on bone, cartilage, and osteochondral tissues have also been widely investigated in vivo through a considerable number of animal studies. The studies involved the use o","[602, 926, 1097, 1238]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,11,paragraph_title,6.1 Bone,"[606, 1279, 710, 1306]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.1 Bone""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +13,12,text,"Analogously to in vitro studies, the in vivo investigation of the effects of PEMF stimulation on bone tissue also shows variations in the applied PEMF parameters among the studies, with magnetic field","[603, 1332, 1096, 1450]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,13,text,"As regards the treatment of bone fractures, in 1974 Bassett and Pawluk conducted the first pioneering study, in which pulsing electromagnetic fields have been inductively coupled to dog bone, resultin","[603, 1452, 1097, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,14,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,15,number,13,"[585, 1599, 606, 1617]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,16,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,2,chart,,"[208, 176, 982, 714]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +14,3,figure_title,"FIGURE 4 +Distribution of the root mean square value of the magnetic field intensity ( $ B_{rms} $) and the PEMF dose (D) value for the in vitro studies performed imposing PEMF stimulation on cartilage","[115, 732, 1075, 799]",figure_caption,0.92,"[""figure_title label: FIGURE 4\nDistribution of the root mean square value of the m""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +14,4,text,"repaired tissue after fracture (Andrew et al., 1974). Subsequent experiments further validated these findings (Bassett et al., 1977; 1978), ultimately leading in 1979 to the first pre-market approval ","[92, 852, 585, 1402]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,text,"Recently, PEMF stimulation has also been explored as a potential adjuvant therapy to enhance implant osseointegration. In case of rabbit bone defects treated with titanium implants, it was reported th","[92, 1402, 586, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,,"[601, 852, 1097, 1427]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +14,7,text,"Over the past decade, researchers have also focused on exploring the potential of PEMF stimulation as a treatment for osteoporosis, for which mice or rats have been used as animal models suitable for ","[602, 1427, 1097, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,8,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +14,9,number,14,"[585, 1600, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,10,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,0,header,Masante et al.,"[95, 68, 192, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,2,figure_title,TABLE 6 In vivo studies on the effects of PEMF stimulation on bone tissue.,"[95, 160, 597, 180]",table_caption,0.9,"[""table prefix matched: TABLE 6 In vivo studies on the effects of PEMF stimulation o""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +15,3,table,
ReferenceSpeciesInvestigated conditionPEMF stimulatorPEMF waveformPEMF parametersPEMF exposureMain biological outcomes/ Si,"[96, 183, 1092, 1511]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +15,4,vision_footnote,(Continued on following page),"[912, 1514, 1094, 1535]",footnote,0.7,"[""vision_footnote label: (Continued on following page)""]",footnote,0.7,body_zone,body_like,none,True,True +15,5,footer,Frontiers in Bioengineering and Biotechnology,"[94, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,6,number,15,"[585, 1600, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,7,footer,frontiersin.org,"[998, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,0,header,Masante et al.,"[95, 68, 191, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,1,header,10.3389/fbioe.2025.1557572,"[907, 68, 1095, 85]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,2,figure_title,TABLE 6 (Continued) In vivo studies on the effects of PEMF stimulation on bone tissue.,"[94, 158, 678, 177]",table_caption,0.9,"[""table prefix matched: TABLE 6 (Continued) In vivo studies on the effects of PEMF s""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +16,3,table,
ReferenceSpeciesInvestigated conditionPEMF stimulatorPEMF waveformPEMF parametersPEMF exposureMain biological outcomes/ Si,"[97, 181, 1093, 1160]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +16,4,text,"female rats with osteopenia and subjected them to PEMF treatment (B = 0.5 mT, f = 15 Hz, triangular waveform, for 3 h/day over 6 weeks), observing increased elastic modulus of the hard callus across f","[93, 1211, 584, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,5,text,,"[602, 1211, 1099, 1545]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +16,6,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +16,7,number,16,"[585, 1600, 607, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,8,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1094, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,2,text,"higher B values (B = 2.5 and 4.5 mT, f = 3,000–50,000 Hz) reduced these effects. Additional findings showed improved trabecular architecture and mechanical properties, with upregulation of Wnt/β-caten","[91, 161, 586, 708]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,3,text,"Since osteopenia and osteoporosis can also result from disuse conditions, such as prolonged bed rest, immobilization after injury, or exposure to altered gravity in space travel, the potential of PEMF","[92, 711, 585, 1379]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,4,text,"Overall, these studies suggest that PEMF can promote bone health by modulating osteogenesis and bone resorption pathways across various pathological conditions, including implant osseointegration, ost","[92, 1379, 586, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,5,paragraph_title,6.2 Quantitative comparison among in vivo studies on PEMF stimulation for bone tissue,"[604, 157, 1094, 206]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.2 Quantitative comparison among in vivo studies on PEMF st""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +17,6,text,"The in vivo investigations of the effects of PEMF stimulation on bone tissue report a wide range of PEMF stimulation parameters (B = 0.1–12.4 mT, f = 1–100 Hz), with studies lasting from 10 days to 12","[603, 232, 1096, 470]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,text,"Interestingly, regarding the use of PEMF for the treatment of osteoporosis-related pathologies, all the reported studies delivered whole-body PEMF stimulation to either rats or mice, enhancing the con","[602, 475, 1099, 1410]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,8,text,"Notably, most of the studies that reported positive effects of in vivo PEMF stimulation on pathological conditions related to osteoporosis (Jing et al., 2014; Li et al., 2017; Lei et al., 2018; Lin et","[602, 1404, 1097, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,9,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 403, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,10,number,17,"[586, 1599, 605, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,11,footer,frontiersin.org,"[998, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1094, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +18,2,chart,,"[207, 179, 983, 614]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +18,3,figure_title,Distribution of the root mean square value of the magnetic field intensity ( $ B_{rms} $) and the PEMF dose (D) value for the in vivo studies performed imposing PEMF stimulation on bone tissue. The li,"[115, 638, 1072, 699]",figure_caption,0.85,"[""figure_title label: Distribution of the root mean square value of the magnetic f""]",figure_caption,0.85,body_zone,legend_like,none,True,True +18,4,text," $ B_{rms} $ values were provided, the corresponding protocols did not prove effective, regardless of the high PEMF dose associated (Lei et al., 2017; Androjna et al., 2021).","[93, 757, 585, 829]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,5,paragraph_title,6.3 Cartilage and osteochondral tissue,"[94, 872, 530, 899]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.3 Cartilage and osteochondral tissue""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +18,6,text,"The promising results of in vitro application of PEMF on cartilage regeneration have prompted investigations into its in vivo effects, with a particular focus on cartilage degeneration and OA in diffe","[91, 926, 587, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,7,text,,"[602, 758, 1097, 1044]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +18,8,text,"Regarding the direct treatment of OA, Veronesi and colleagues exposed guinea pigs with OA to PEMF stimulation (B = 1.3 mT for 6 h/day over 3 months) imposing two different frequencies (f = 37 or 75 Hz","[602, 1047, 1098, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,9,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +18,10,number,18,"[585, 1599, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,11,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,0,header,Masante et al.,"[95, 68, 192, 86]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +19,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +19,2,figure_title,TABLE 7 In vivo studies on the effects of PEMF stimulation on cartilage and osteochondral tissue.,"[95, 160, 748, 180]",table_caption,0.9,"[""table prefix matched: TABLE 7 In vivo studies on the effects of PEMF stimulation o""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +19,3,table,
ReferenceSpeciesInvestigated conditionPEMF stimulatorPEMF waveformPEMF parametersPEMF exposureMain biological outcomes/ Si,"[97, 182, 1093, 1193]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,,unknown_like,none,True,True +19,4,text,"OA. Both PEMF stimulation (B = 1.6 mT, f = 75 Hz, square waveform, for 1 h/day) and vibration treatment (frequency = 5 Hz, amplitude = 4 mm, gravitational acceleration = 0.3 g, for 20 min/day) were ap","[92, 1235, 586, 1547]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +19,5,text,,"[602, 1235, 1098, 1355]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +19,6,text,"In summary, it has been demonstrated that PEMF treatment can improve cartilage health, enhance matrix parameters, and inhibit degenerative processes in osteochondral tissue. In addition, PEMF can modu","[602, 1356, 1098, 1547]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +19,7,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +19,8,number,19,"[585, 1599, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +19,9,footer,frontiersin.org,"[997, 1598, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +20,0,header,Masante et al.,"[96, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +20,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +20,2,chart,,"[239, 178, 954, 659]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +20,3,figure_title,Distribution of the root mean square value of the magnetic field intensity $ (B_{rms}) $ and the PEMF dose $ (D) $ value for the in vivo studies performed imposing PEMF stimulation on cartilage and ,"[119, 686, 1036, 727]",figure_caption,0.85,"[""figure_title label: Distribution of the root mean square value of the magnetic f""]",figure_caption,0.85,tail_nonref_hold_zone,legend_like,none,True,True +20,4,paragraph_title,6.4 Quantitative comparison among in vivo studies on PEMF stimulation for cartilage and osteochondral tissue,"[94, 777, 583, 853]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.4 Quantitative comparison among in vivo studies on PEMF st""]",subsection_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True +20,5,text,"Besides variations in the intensity of the imposed magnetic field (resulting in $ B_{rms} $ values ranging from 0.19 to 5.66 mT, Figure 6), in vivo studies on PEMF stimulation investigating its effec","[92, 877, 585, 1261]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +20,6,paragraph_title,7 Concluding remarks,"[94, 1302, 377, 1330]",section_heading,0.85,"[""paragraph_title label with numbering: 7 Concluding remarks""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +20,7,text,"Over the past three decades, due to its non-invasiveness and promising outcomes, PEMF stimulation has gained widespread adoption as a clinical intervention for enhancing the treatment of various bone ","[92, 1355, 586, 1547]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +20,8,text,,"[602, 780, 1097, 1068]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +20,9,text,"However, this variability in experimental set-ups and imposed PEMF parameters complicates the direct comparison of outcomes across studies. This challenge is further compounded by inconsistencies in d","[601, 1069, 1098, 1548]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +20,10,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +20,11,number,20,"[584, 1599, 607, 1616]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +20,12,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +21,0,header,Masante et al.,"[95, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +21,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +21,2,text,evidence with greater translational relevance. These examples demonstrate that it is indeed feasible to design and implement protocols that maintain parameter fidelity throughout the translational pip,"[92, 160, 585, 279]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +21,3,text,"To facilitate the comparability of past and future research, here we proposed a quantitative approach based on the calculation of the PEMF dose—a comprehensive metric that integrates magnetic field in","[92, 280, 586, 902]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +21,4,text,"The method proposed for quantitative comparison is affected by some limitations. In the PEMF dose calculation, the frequency and pulse duration parameters are combined in the duty cycle and do not acc","[92, 902, 586, 1259]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +21,5,text,"For the future of PEMF research, it would be desirable to use, at least initially, the same parameters to ensure better comparability. Subsequently, it would make sense to systematically vary the vari","[92, 1262, 586, 1549]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True +21,6,text,,"[603, 161, 1098, 565]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True +21,7,text,"In conclusion, this review provides a comprehensive overview of the current state of the art of in vitro and in vivo experiments investigating the biological effects of PEMF stimulation on bone and ca","[603, 567, 1098, 999]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +21,8,paragraph_title,Author contributions,"[604, 1039, 873, 1067]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,True,True +21,9,text,"BM: Conceptualization, Investigation, Visualization, Writing – original draft. SG: Conceptualization, Formal Analysis, Investigation, Methodology, Writing – original draft. JS: Writing – original draf","[603, 1092, 1096, 1310]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +21,10,paragraph_title,Funding,"[606, 1350, 712, 1379]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Funding""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +21,11,text,The author(s) declare that financial support was received for the research and/or publication of this article. This study was carried out within the scope of: 1) the BIGMECH project funded by European,"[602, 1404, 1097, 1548]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +21,12,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1598, 404, 1619]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +21,13,number,21,"[585, 1599, 605, 1616]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +21,14,footer,frontiersin.org,"[997, 1599, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +22,0,header,Masante et al.,"[95, 67, 191, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,1,header,10.3389/fbioe.2025.1557572,"[907, 67, 1095, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +22,2,text,"Marie Skłodowska-Curie Actions Individual Postdoctoral Fellowship 2023 (awarded to João C. Silva, HORIZON-MSCA-2023-PF-01, Project No. 101155027). This manuscript reflects only the authors' views and ","[92, 159, 586, 305]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,3,paragraph_title,Acknowledgments,"[94, 346, 332, 375]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +22,4,text,The authors are grateful to Prof. Aldo Canova for technical explanations about PEMF generation and to Simona Salati from IGEA S.p.A. for the fruitful and valuable discussions on the perspectives of PE,"[92, 399, 585, 498]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,5,paragraph_title,Conflict of interest,"[94, 536, 338, 565]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +22,6,text,The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.,"[93, 590, 585, 662]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +22,7,paragraph_title,Generative AI statement,"[604, 154, 915, 183]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Generative AI statement""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +22,8,paragraph_title,References,"[96, 705, 240, 732]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +22,9,paragraph_title,Publisher's note,"[605, 297, 813, 326]",backmatter_heading,0.8,"[""backmatter heading on page 22: Publisher's note""]",backmatter_heading_candidate,0.8,body_zone,support_like,short_fragment,True,True +22,10,text,The author(s) declare that no Generative AI was used in the creation of this manuscript.,"[603, 207, 1095, 256]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,11,text,"All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.","[603, 351, 1097, 497]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,12,paragraph_title,Supplementary material,"[604, 536, 909, 567]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supplementary material""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +22,13,text,The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbioe.2025.1557572/full#supplementary-material,"[604, 590, 1096, 662]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,14,reference_content,"Amin, B., Elahi, M. 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Biochimica Biophysica Acta (BBA) - Mo","[95, 400, 584, 464]",reference_item,0.85,"[""reference content label: Wiesmann, H.-P., Hartig, M., Stratmann, U., Meyer, U., and J""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,7,reference_content,"Willers, C., Norton, N., Harvey, N. C., Jacobson, T., Johansson, H., Lorentzon, M., et al. (2022). Osteoporosis in Europe: a compendium of country-specific reports. Arch. Osteoporos. 17, 23. doi:10.10","[96, 471, 583, 521]",reference_item,0.85,"[""reference content label: Willers, C., Norton, N., Harvey, N. C., Jacobson, T., Johans""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,8,reference_content,"Wu, A.-M., Bisignano, C., James, S. L., Abady, G. G., Abedi, A., Abu-Gharbieh, E., et al. (2021). Global, regional, and national burden of bone fractures in 204 countries and territories, 1990–2019: a","[96, 527, 584, 592]",reference_item,0.85,"[""reference content label: Wu, A.-M., Bisignano, C., James, S. 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A., Schwarz, T., Mustafa, K., and Han""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,11,reference_content,"Yang, X., Guo, H., Ye, W., Yang, L., and He, C. (2021). Pulsed electromagnetic field attenuates osteoarthritis progression in a murine destabilization-induced model through inhibition of TNF- $ \alpha","[96, 742, 583, 806]",reference_item,0.85,"[""reference content label: Yang, X., Guo, H., Ye, W., Yang, L., and He, C. (2021). Puls""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,12,reference_content,"Yang, X., He, H., Zhou, Y., Zhou, Y., Gao, Q., Wang, P., et al. (2017). Pulsed electromagnetic field at different stages of knee osteoarthritis in rats induced by low-dose monosodium iodoacetate: effe","[95, 814, 584, 863]",reference_item,0.85,"[""reference content label: Yang, X., He, H., Zhou, Y., Zhou, Y., Gao, Q., Wang, P., et ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,13,reference_content,"microarchitecture and cartilage degradation. Bioelectromagnetics 38, 227–238. doi:10.1002/bem.22028","[607, 161, 1093, 194]",reference_item,0.85,"[""reference content label: microarchitecture and cartilage degradation. Bioelectromagne""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,14,reference_content,"Ye, W., Guo, H., Yang, X., Yang, L., and He, C. (2020). Pulsed electromagnetic field versus whole body vibration on cartilage and subchondral trabecular bone in mice with knee osteoarthritis. Bioelect","[607, 200, 1094, 249]",reference_item,0.85,"[""reference content label: Ye, W., Guo, H., Yang, X., Yang, L., and He, C. (2020). Puls""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,15,reference_content,"Yin, Y., Chen, P., Yu, Q., Peng, Y., Zhu, Z., and Tian, J. (2018). The effects of a pulsed electromagnetic field on the proliferation and osteogenic differentiation of human adipose-derived stem cells","[608, 256, 1093, 306]",reference_item,0.85,"[""reference content label: Yin, Y., Chen, P., Yu, Q., Peng, Y., Zhu, Z., and Tian, J. (""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,16,reference_content,"Yuan, J., Xin, F., and Jiang, W. (2018). Underlying signaling pathways and therapeutic applications of pulsed electromagnetic fields in bone repair. Cell Physiol. Biochem. 46, 1581–1594. doi:10.1159/0","[607, 368, 1094, 417]",reference_item,0.85,"[""reference content label: Yuan, J., Xin, F., and Jiang, W. (2018). Underlying signalin""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,17,reference_content,"Yong, Y., Ming, Z. D., Feng, L., Chun, Z. W., and Hua, W. (2014). Electromagnetic fields promote osteogenesis of rat mesenchymal stem cells through the PKA and ERK1/2 pathways. J. Tissue Eng. Regen. M","[607, 312, 1093, 360]",reference_item,0.85,"[""reference content label: Yong, Y., Ming, Z. D., Feng, L., Chun, Z. W., and Hua, W. (2""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,18,reference_content,"Zha, K., Tian, Y., Panayi, A. C., Mi, B., and Liu, G. (2022). Recent advances in enhancement strategies for osteogenic differentiation of mesenchymal stem cells in bone tissue engineering. Front. Cell","[606, 424, 1094, 473]",reference_item,0.85,"[""reference content label: Zha, K., Tian, Y., Panayi, A. C., Mi, B., and Liu, G. (2022)""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,19,reference_content,"Zhou, J., Chen, S., Guo, H., Xia, L., Liu, H., Qin, Y., et al. (2013). Pulsed electromagnetic field stimulates osteoprotegerin and reduces RANKL expression in ovariectomized rats. Rheumatol. Int. 33, ","[606, 479, 1094, 528]",reference_item,0.85,"[""reference content label: Zhou, J., Chen, S., Guo, H., Xia, L., Liu, H., Qin, Y., et a""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,20,reference_content,"Zhou, J., Liao, Y., Xie, H., Liao, Y., Liu, H., Zeng, Y., et al. (2017). Pulsed electromagnetic field ameliorates cartilage degeneration by inhibiting mitogen-activated protein kinases in a rat model ","[607, 535, 1094, 600]",reference_item,0.85,"[""reference content label: Zhou, J., Liao, Y., Xie, H., Liao, Y., Liu, H., Zeng, Y., et""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,21,reference_content,"Zhou, J., Ming, L.-G., Ge, B.-F., Wang, J.-Q., Zhu, R.-Q., Wei, Z., et al. (2011). Effects of 50Hz sinusoidal electromagnetic fields of different intensities on proliferation, differentiation and mine","[607, 607, 1093, 671]",reference_item,0.85,"[""reference content label: Zhou, J., Ming, L.-G., Ge, B.-F., Wang, J.-Q., Zhu, R.-Q., W""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,22,reference_content,"Zhou, J., Wang, J.-Q., Ge, B.-F., Ma, X.-N., Ma, H.-P., Xian, C. J., et al. (2014). Different electromagnetic field waveforms have different effects on proliferation, differentiation and mineralizatio","[607, 679, 1093, 744]",reference_item,0.85,"[""reference content label: Zhou, J., Wang, J.-Q., Ge, B.-F., Ma, X.-N., Ma, H.-P., Xian""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,23,reference_content,"Zhou, X., Castro, N. J., Zhu, W., Cui, H., Aliabouzar, M., Sarkar, K., et al. (2016a). Improved human bone marrow mesenchymal stem cell osteogenesis in 3D bioprinted tissue scaffolds with low intensit","[607, 751, 1093, 814]",reference_item,0.85,"[""reference content label: Zhou, X., Castro, N. J., Zhu, W., Cui, H., Aliabouzar, M., S""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,24,reference_content,"Zhou, Z., Qian, D., and Minary-Jolandan, M. (2016b). Molecular mechanism of polarization and piezoelectric effect in super-twisted collagen. ACS Biomater. Sci. Eng. 2, 929–936. doi:10.1021/acsbiomater","[607, 821, 1095, 870]",reference_item,0.85,"[""reference content label: Zhou, Z., Qian, D., and Minary-Jolandan, M. (2016b). Molecul""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +26,25,footer,Frontiers in Bioengineering and Biotechnology,"[95, 1599, 403, 1618]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +26,26,number,26,"[584, 1600, 606, 1616]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +26,27,footer,frontiersin.org,"[998, 1600, 1094, 1618]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/7S5ZEVSK/block_trace.csv b/tests/fixtures/ocr_real_papers/7S5ZEVSK/block_trace.csv new file mode 100644 index 00000000..c509553c --- /dev/null +++ b/tests/fixtures/ocr_real_papers/7S5ZEVSK/block_trace.csv @@ -0,0 +1,179 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[71, 94, 140, 161]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header,"Journal of +Clinical Medicine","[146, 102, 339, 156]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,header_image,,"[1030, 103, 1120, 161]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,3,text,Article,"[67, 201, 131, 225]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,MR Imaging Biomarkers for Clinical Impairment and Disease Progression in Patients with Shoulder Adhesive Capsulitis: A Prospective Study,"[67, 226, 1088, 344]",paper_title,0.8,"[""page-1 zone title_zone: MR Imaging Biomarkers for Clinical Impairment and Disease Pr""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Romain Gillet $ ^{1,*} $, François Zhu $ ^{1} $, Pierre Padoin $ ^{1} $, Aymeric Rauch $ ^{1} $, Gabriela Hossu $ ^{2} $, Pedro Augusto Gondim Teixeira $ ^{1} $ and Alain Blum $ ^{1} $","[66, 373, 856, 426]",authors,0.8,"[""page-1 zone author_zone: Romain Gillet $ ^{1,*} $, Fran\u00e7ois Zhu $ ^{1} $, Pierre Pado""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text,"Guilloz Imaging Department, Central Hospital, University Hospital Center of Nancy, 54000 Nancy, France; f.zhu@chru-nancy.fr (F.Z.); pierre.padoin@gmail.com (P.P.); aym.rauch@gmail.com (A.R.); p.teixei","[327, 461, 1114, 529]",affiliation,0.8,"[""page-1 zone affiliation_zone: Guilloz Imaging Department, Central Hospital, University Hos""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text," $ ^{2} $ CIC-II, CHKU Nancy, Université de Lorraine, 54000 Nancy, France; g.hossu@chru-nancy.fr","[329, 526, 1004, 549]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $ CIC-II, CHKU Nancy, Universit\u00e9 de Lorraine, 54000 N""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,8,image,,"[69, 729, 176, 766]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,9,text,* Correspondence: r.gillet@chru-nancy.fr; Tel.: +33-3-83-85-21-61; Fax: +33-3-83-85-97-25,"[327, 549, 975, 570]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: r.gillet@chru-nancy.fr; Tel.: +33-3-83-85-""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,10,text,"Citation: Gillet, R.; Zhu, F.; Padoin, P.; Rauch, A.; Hossu, G.; Teixeira, P.A.G.; Blum, A. MR Imaging Biomarkers for Clinical Impairment and Disease Progression in Patients with Shoulder Adhesive Cap","[66, 779, 309, 992]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Gillet, R.; Zhu, F.; Padoin, P.; Rauch, A.; Hossu,""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,text,"Received: 3 August 2021 +Accepted: 27 August 2021 +Published: 29 August 2021","[68, 1089, 238, 1159]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 3 August 2021 \nAccepted: 27 August 2021 \nPublish""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,12,text,Academic Editors: Mihra Taljanovic and Iwona Sudol-Szopińska,"[67, 1018, 297, 1063]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,13,text,Publisher's Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[67, 1188, 311, 1279]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=frontmatter_main_zone"", ""style_family=support_like""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False +1,14,image,,"[70, 1314, 187, 1358]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,15,text,"Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66, 1366, 311, 1553]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2021 by the authors. Licensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,16,abstract,"Abstract: Background: MRI diagnostic criteria of shoulder adhesive capsulitis (AC) are nowadays widely used, but there is little information available on the association between MRI findings and clini","[327, 598, 1124, 1115]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,17,text,Keywords: adhesive capsulitis; MRI; shoulder; constant-murley score; inferior gleno-humeral ligament,"[328, 1142, 1122, 1167]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: adhesive capsulitis; MRI; shoulder; constant-murle""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,18,paragraph_title,1. Introduction,"[331, 1241, 474, 1264]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,19,text,"Adhesive capsulitis (AC) of the shoulder is a common condition with an incidence in the general population varying considerably from 2 to 5.3% for primary and from 4.3 to 38% for secondary AC (e.g., A","[327, 1272, 1125, 1497]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,text,"AC is classically diagnosed based on clinical presentation, medical history, and physical examination. Diagnosing this condition, however, can be challenging as AC may occur","[328, 1498, 1126, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,21,footer,"J. Clin. Med. 2021, 10, 3882. https://doi.org/10.3390/jcm10173882","[67, 1624, 537, 1647]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,22,footer,https://www.mdpi.com/journal/jcm,"[842, 1625, 1118, 1648]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 125]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,number,2 of 14,"[1069, 103, 1121, 125]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,2,text,"in various clinical scenarios and has multiple potential differential diagnoses (e.g., rotator cuff tears, calcifying tendonitis, osteoarthritis, inflammatory tumors …) [2]. Imaging plays an ever-grow","[328, 189, 1123, 365]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Patients with AC typically complain of a gradual and progressive onset of pain, sleep-disturbing night pain, and active and passive limitation at various degrees of ranges of motion (ROM), both in ele","[327, 365, 1126, 669]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,paragraph_title,2. Material and Methods 2.1. Study Group,"[330, 686, 562, 738]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Material and Methods 2.1. Study Group""]",section_heading,0.85,frontmatter_side_zone,heading_like,heading_numbered,True,True +2,5,footer,,"[330, 713, 481, 738]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,6,text,"Our institutional review board approved this study, and all patients gave written informed consent. From 10 October 2013 to 16 October 2017, 170 patients over 18 years of age were enrolled prospective","[327, 745, 1123, 869]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"Patients with MRI contraindications, prior shoulder surgery, severe rotator cuff damage with at least a full-thickness tear of one tendon, shoulder osteoarthritis (osteophytes on radiographs), calcifi","[327, 871, 1124, 1098]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,2.2. Shoulder Function Assessment,"[330, 1115, 625, 1138]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Shoulder Function Assessment""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,text,A modified CMS was applied to all patients by a senior radiologist just prior to the MRI examination [19]. Two subjective variables for a maximum score of 35 were evaluated: daily living pain (varying,"[328, 1148, 1124, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 103, 258, 125]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,3 of 14,"[1069, 103, 1120, 125]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,2,text,"In addition to the modified CMS score, the pain duration was graded as follows:","[371, 192, 1087, 218]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,1 = less than 6 weeks,"[330, 224, 524, 247]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,4,text,2 = between 6 weeks and 3 months,"[330, 249, 647, 273]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,5,text,3 = between 3 and 6 months,"[330, 274, 586, 298]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,6,text,4 = between 6 months and 1 year,"[330, 300, 629, 323]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +3,7,text,5 = over 1 year,"[330, 325, 470, 349]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,reference_like,reference_numeric_dot,False,True +3,8,text,"The presence of diurnal pain, nocturnal pain, and nocturnal pain predominance were also evaluated.","[328, 356, 1121, 406]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,2.3. Clinical Follow-Up,"[330, 425, 529, 450]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Clinical Follow-Up""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,10,text,A clinical follow-up was available in a sub-group of 49 patients with a mean age of $ 54 \pm 8.8 $ (37–74) years treated by physical therapy. Other patients were lost to follow-up or were treated in ,"[328, 456, 1123, 634]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,2.4. Mri Examination,"[330, 652, 516, 675]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Mri Examination""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,12,text,"MRI examinations were performed with either a 1.5 T (105 patients) or a 3.0 T (27 patients) scanner (Signa HDxt, GE Healthcare, Milwaukee, WI, USA) using a dedicated eight-channel shoulder coil and si","[327, 682, 1125, 758]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,text,"All MRI examinations consisted of an axial and oblique sagittal fast spin-echo (FSE) T1-weighted acquisitions (at 1.5 T: TR/TE, 500/10; echo-train length (ETL), 2; matrix, 352 × 320; NEX, 0.5; FOV, 16","[327, 758, 1125, 961]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,paragraph_title,2.5. Image Analysis,"[330, 979, 500, 1004]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Image Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,15,text,"The images were retrospectively reviewed by two musculoskeletal radiologists with three (FZ) and seven years (PP) of clinical experience with MRI using a PACS station (Synapse $ ^{\circledR} $, v4.1.6","[327, 1010, 1123, 1160]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,16,text,The signal intensity of the IGHL on oblique coronal T2-weighted fat-saturated images was graded as follows (Figure 1):,"[329, 1161, 1122, 1212]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,17,text,1: normal homogenous low signal intensity,"[330, 1217, 722, 1243]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,18,text,2: partial or foci of signal hyperintensity,"[330, 1243, 694, 1267]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,19,text,3: global signal hyperintensity,"[330, 1268, 607, 1291]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,20,text,4: linear hyperintensity of the peri-articular soft tissues,"[330, 1292, 823, 1317]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 125]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,4 of 14,"[1069, 103, 1121, 125]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,2,image,,"[193, 196, 997, 883]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,3,figure_title,Figure 1. (a–d) Frontal oblique non-contrast fat-suppressed T2-weighted fast spin-echo MRI shows method used to grade glenohumeral inferior ligament signal on its glenoidal (white arrow) and humeral (,"[108, 905, 1083, 1085]",figure_caption,0.92,"[""figure_title label: Figure 1. (a\u2013d) Frontal oblique non-contrast fat-suppressed ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,4,text,"The whole ligamentous complex was considered in the analysis: the anterior band, posterior band, and hammock portion. The patients with IGHL scores of 1 and 2 were considered to have a low IGHL signal","[326, 1103, 1125, 1356]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 126]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,5 of 14,"[1069, 102, 1121, 125]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,2,image,,"[342, 198, 818, 777]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,Figure 2. Coronal oblique non-contrast fat-suppressed T2-weighted fast spin-echo MRI of the right shoulder in a 44-year-old woman with adhesive capsulitis shows method used to measure inferior glenohu,"[327, 799, 1125, 903]",figure_caption,0.92,"[""figure_title label: Figure 2. Coronal oblique non-contrast fat-suppressed T2-wei""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,4,image,,"[341, 934, 842, 1449]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,figure_title,Figure 3. Sagittal oblique non-contrast fat-suppressed T2-weighted fast spin-echo MRI of the left shoulder in a 55-year-old man with adhesive capsulitis shows method used to measure coracohumeral liga,"[328, 1472, 1124, 1551]",figure_caption,0.92,"[""figure_title label: Figure 3. Sagittal oblique non-contrast fat-suppressed T2-we""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 125]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,6 of 14,"[1069, 103, 1121, 125]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,2,paragraph_title,2.6. Statistical Analysis,"[330, 192, 533, 217]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,3,text,"The R Development Core Team software (version 3.0.12013, R Foundation for Statistical Computing, Vienna, Austria) was used to perform statistical analysis. Statistical significance for all tests was d","[327, 224, 1123, 323]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,citation_line,True,True +6,4,text,"Linear regression analysis with the Pearson test was used to evaluate the correlation between the signs of AC studied on MRI and pain, mobility, activity scores, and pain duration. The association bet","[326, 325, 1125, 526]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,paragraph_title,3. Results,"[329, 545, 428, 569]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,6,text,"Table 1 shows demographic characteristics and modified CMS in the study population. The mean global modified CMS was $ 31.3 \pm 14.2 $ (2–69) points, and the mean pain duration grade was $ 3.5 \pm 1","[326, 576, 1125, 778]",table_caption,0.9,"[""table prefix matched: Table 1 shows demographic characteristics and modified CMS i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,7,figure_title,Table 1. Summary of patients' ages and clinical impairment items.,"[326, 796, 861, 819]",table_caption,0.9,"[""table prefix matched: Table 1. Summary of patients' ages and clinical impairment i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,8,table,
ParameterMinimumMaximumMeanStandard Deviation
Patient Age
All patients ( $ n = ,"[70, 828, 1118, 1074]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,9,figure_title,Table 2. Summary of patients' pain characteristics.,"[329, 1112, 738, 1136]",table_caption,0.9,"[""table prefix matched: Table 2. Summary of patients' pain characteristics.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,10,table,","[70, 490, 1119, 629]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +7,7,vision_footnote,"Values are given in millimeters. IGHL: inferior glenohumeral ligament, CHL: coracohumeral ligament. R1: Reader 1, R2: Reader 2.","[130, 634, 1058, 656]",footnote,0.7,"[""vision_footnote label: Values are given in millimeters. IGHL: inferior glenohumeral""]",footnote,0.7,body_zone,body_like,none,True,True +7,8,text,"ICC was excellent in grading IGHL signal as low or high (0.96), and moderate when taking in account all the four grades (0.67). ICC values were moderate for IGHL thickness (glenoidal insertion: 0.72, ","[326, 679, 1122, 756]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,Mobility scores were significantly different in patients with high IGHL signal intensity compared to those with low intensity for both readers (p = 0.04 and 0.02 for readers 1 and 2). The mean mobilit,"[327, 755, 1124, 905]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,"For both readers, pain duration was significantly shorter in patients with high IGHL signal intensity compared to those with a low signal IGHL (p = 0.03 and 0.04 for readers 1 and 2). The pain duratio","[327, 906, 1124, 1105]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,text,"The glenoidal IGHL thickness was significantly correlated with activity limitation scores for reader 1 (p = 0.005). Patients with IGHL measuring < 4 mm, between 4 and <6 mm, and ≥6 mm presented a prog","[327, 1106, 1125, 1458]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,12,text,CHL measurements are shown in Table 4. This ligament could not be measured confidently in five patients for reader 1 and 20 patients for reader 2. There was no association between CHL thickness and cl,"[327, 1458, 1125, 1533]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 126]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 14,"[1068, 103, 1121, 125]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,chart,,"[125, 202, 1064, 1135]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,3,figure_title,Figure 4. Box-plot showing mean mobility score (y-axis) according to inferior glenohumeral ligament intensity grade (x-axis) for reader 1 and reader 2.,"[108, 1158, 1083, 1209]",figure_caption,0.92,"[""figure_title label: Figure 4. Box-plot showing mean mobility score (y-axis) acco""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 103, 259, 125]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,number,9 of 14,"[1069, 103, 1121, 124]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,chart,,"[85, 204, 1112, 1143]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,3,figure_title,"Figure 5. Bar plot representing pain score duration (PDS) (number of patients on y-axis) according to inferior glenohumeral ligament signal intensity (IGHL SI) (x-axis), shown for reader 1 for grade 1","[108, 1176, 1084, 1254]",figure_caption,0.92,"[""figure_title label: Figure 5. Bar plot representing pain score duration (PDS) (n""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,4,text,"Concerning disease progression, 31 patients (13 men, 18 women, mean age $ 55 \pm 9.1 $ (38–74) years) showed improvement, 11 patients (2 men, 9 women, mean age $ 55 \pm 10.1 $ (37–67) years) stabili","[327, 1270, 1125, 1550]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 126]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +10,1,number,10 of 14,"[1062, 102, 1121, 126]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,text," $ (p = 0.2) $. For both readers, the presence of high IGHL signal intensity was not significantly correlated with disease progression $ (p > 0.05) $. In patients with worsening, IGHL was found to be","[328, 191, 1123, 296]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +10,3,image,,"[82, 345, 1108, 1385]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +10,4,figure_title,"Figure 6. Box plot representing inferior glenohumeral ligament thickness (y-axis) according to clinical outcomes for reader 1 on the glenoidal (a) and humeral side (b), and for reader 2 on the glenoid","[108, 1406, 1082, 1458]",figure_caption_candidate,0.92,"[""figure_title label: Figure 6. Box plot representing inferior glenohumeral ligame""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +10,5,text,"For both readers, there was no association between CMS modified global score, pain intensity grade, diurnal pain, and MRI findings.","[327, 1475, 1125, 1529]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 125]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +11,1,header,11 of 14,"[1062, 103, 1121, 125]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,paragraph_title,4. Discussion,"[329, 193, 460, 216]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True +11,3,text,"Our study showed a significant correlation between high IGHL signal intensity and the pain duration in patients with AC, with a clear high signal predominance in the patients presenting with pain from","[326, 222, 1124, 953]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,4,text,"Unlike Anh et al. [26], we did not find any correlation between MRI findings and the degree of pain, but we did not rate IGHL enhancement, as its signal on T2-weighted fat-saturated FSE images has bee","[327, 952, 1126, 1304]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +11,5,text,"This study has limitations. Most importantly, AC diagnosis was confirmed neither by arthroscopy nor histologically. However, clinical findings remain the basis for the diagnosis of AC, and the diagnos","[326, 1304, 1125, 1557]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +12,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 102, 259, 125]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,12 of 14,"[1062, 103, 1121, 125]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,text,"heterogeneous with various disease stages and clinical impairment levels; however, the study population is one of the largest reported so far and is representative of routine clinical practice. Finall","[327, 193, 1123, 292]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,text,"In conclusion, two potentially useful MR biomarkers in patients with AC could be identified. First, the increased T2 signal intensity at the IGHL, which is an indicator of an early inflammatory phase ","[327, 294, 1124, 470]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,"Supplementary Materials: The following are available online at https://www.mdpi.com/article/10.3390/jcm10173882/s1, Table S1: Modified Constant-Murley Score.","[328, 493, 1123, 541]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"Author Contributions: Conceptualization, R.G. and P.A.G.T.; methodology, P.A.G.T.; software, G.H.; validation, R.G., A.B. and P.A.G.T. formal analysis, A.B.; investigation, A.R.; resources, F.Z. and P","[328, 552, 1126, 670]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,support_like,none,True,True +12,6,text,Funding: This research received no external funding.,"[330, 682, 759, 706]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,text,Institutional Review Board Statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of the University Hospital of Na,"[328, 717, 1123, 788]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,8,text,Informed Consent Statement: Written informed consent was obtained from all subjects involved in the study.,"[328, 799, 1123, 846]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,Conflicts of Interest: The authors declare no conflict of interest.,"[329, 858, 842, 882]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +12,10,paragraph_title,Abbreviations,"[330, 906, 468, 930]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Abbreviations""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +12,11,table,
ParameterEffective
Pain Duration Graden = 112 $ * $
14.5% (n = 5)
213.4% (n = 15)
IGHL Signal IntensityPain Duration Grade
Reader 1Reader 2Reader 1Reader 2
ParameterMinimumMaximumMeanStandard Deviation
R1R2R1
,"[325, 955, 773, 1142]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +12,12,paragraph_title,References,"[68, 1166, 176, 1189]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +12,13,reference_content,"1. Kelley, M.J.; Shaffer, M.A.; Kuhn, J.E.; Michener, L.A.; Seitz, A.L.; Uhl, T.L.; Godges, J.J.; McClure, P. Shoulder Pain and Mobility Deficits: Adhesive Capsulitis: Clinical Practice Guidelines Lin","[67, 1197, 1123, 1286]",reference_item,0.85,"[""reference content label: 1. Kelley, M.J.; Shaffer, M.A.; Kuhn, J.E.; Michener, L.A.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,14,reference_content,"2. Brue, S.; Valentin, A.; Forssblad, M.; Werner, S.; Mikkelsen, C.; Cerulli, G. Idiopathic adhesive capsulitis of the shoulder: A review. Knee Surg. Sports Traumatol. Arthrosc. 2007, 15, 1048–1054. [","[67, 1289, 1123, 1333]",reference_item,0.85,"[""reference content label: 2. Brue, S.; Valentin, A.; Forssblad, M.; Werner, S.; Mikkel""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,15,reference_content,"3. D'Orsi, G.M.; Via, A.G.; Frizziero, A.; Oliva, F. Treatment of adhesive capsulitis: A review. Muscles Ligaments Tendons J. 2012, 2, 70–78.","[67, 1335, 1123, 1377]",reference_item,0.85,"[""reference content label: 3. D'Orsi, G.M.; Via, A.G.; Frizziero, A.; Oliva, F. Treatme""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,16,reference_content,"4. Sano, H.; Hatori, M.; Mineta, M.; Hosaka, M.; Itoi, E. Tumors masked as frozen shoulders: A retrospective analysis. J. Shoulder Elbow Surg. 2010, 19, 262–266. [CrossRef]","[68, 1381, 1122, 1424]",reference_item,0.85,"[""reference content label: 4. Sano, H.; Hatori, M.; Mineta, M.; Hosaka, M.; Itoi, E. Tu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,17,reference_content,"5. Zappia, M.; Di Pietto, F.; Aliprandi, A.; Pozza, S.; De Petro, P.; Muda, A.; Sconfienza, L.M. Multi-modal imaging of adhesive capsulitis of the shoulder. Insights Imaging 2016, 7, 365–371. [CrossRe","[67, 1427, 1122, 1471]",reference_item,0.85,"[""reference content label: 5. Zappia, M.; Di Pietto, F.; Aliprandi, A.; Pozza, S.; De P""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +12,18,reference_content,"6. Teixeira, P.A.G.; Balaj, C.; Chanson, A.; Lecocq, S.; Louis, M.; Blum, A. Adhesive Capsulitis of the Shoulder: Value of Inferior Glenohumeral Ligament Signal Changes on T2-Weighted Fat-Saturated Im","[67, 1473, 1123, 1540]",reference_item,0.85,"[""reference content label: 6. Teixeira, P.A.G.; Balaj, C.; Chanson, A.; Lecocq, S.; Lou""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,0,header,"J. Clin. Med. 2021, 10, 3882","[67, 103, 259, 125]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +13,1,number,13 of 14,"[1062, 103, 1121, 125]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +13,2,reference_content,"7. Suh, C.H.; Yun, S.J.; Jin, W.; Lee, S.H.; Park, S.Y.; Park, J.S.; Ryu, K.N. Systematic review and meta-analysis of magnetic resonance imaging features for diagnosis of adhesive capsulitis of the sh","[66, 194, 1119, 240]",reference_item,0.85,"[""reference content label: 7. Suh, C.H.; Yun, S.J.; Jin, W.; Lee, S.H.; Park, S.Y.; Par""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,3,reference_content,"8. Song, K.D.; Kwon, J.W.; Yoon, Y.C.; Choi, S.-H. Indirect MR Arthrographic Findings of Adhesive Capsulitis. Am. J. Roentgenol. 2011, 197, W1105–W1109. [CrossRef]","[66, 240, 1123, 284]",reference_item,0.85,"[""reference content label: 8. Song, K.D.; Kwon, J.W.; Yoon, Y.C.; Choi, S.-H. Indirect ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,4,reference_content,"9. Mengiardi, B.; Pfirrmann, C.W.A.; Gerber, C.; Hodler, J.; Zanetti, M. Frozen Shoulder: MR Arthrographic Findings. Radiology 2004, 233, 486–492. [CrossRef] [PubMed]","[67, 286, 1122, 330]",reference_item,0.85,"[""reference content label: 9. Mengiardi, B.; Pfirrmann, C.W.A.; Gerber, C.; Hodler, J.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +13,5,reference_content,"10. Letevre-Colau, M.-M.; Drapé, J.-L.; Fayad, F.; Rannou, F.; Diche, T.; Minvielle, F.; Demaille-Wlodyka, S.; Mayoux-Benhamou, M.-A.; Fermanian, J.; Poiraudeau, S.; et al. 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Determination of magnetic resonance imaging criteria for diagnosis of adhesive capsulitis. Rheumatol. Int. 2019, 39, 453–460. [CrossRef] [PubM","[68, 770, 1120, 814]",reference_item,0.85,"[""reference content label: 46. Jung, J.H.; Kim, D.H.; Yi, J.; Kim, D.-H.; Cho, C.-H. De""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +14,15,reference_content,"47. Gokalp, G.; Algin, O.; Yildirim, N.; Yazici, Z. Adhesive capsulitis: Contrast-enhanced shoulder MRI findings: Adhesive capsulitis: MRI. J. Med Imaging Radiat. Oncol. 2011, 55, 119–125. [CrossRef]","[67, 816, 1123, 860]",reference_item,0.85,"[""reference content label: 47. Gokalp, G.; Algin, O.; Yildirim, N.; Yazici, Z. Adhesive""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/tests/fixtures/ocr_real_papers/8K39NHUQ/block_trace.csv b/tests/fixtures/ocr_real_papers/8K39NHUQ/block_trace.csv new file mode 100644 index 00000000..dbe70406 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/8K39NHUQ/block_trace.csv @@ -0,0 +1,257 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[70, 100, 139, 168]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,1,header,biomedicines,"[147, 113, 397, 159]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,2,header_image,,"[1030, 109, 1119, 168]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,3,text,Article,"[66, 207, 131, 231]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair,"[66, 232, 1016, 311]",paper_title,0.8,"[""page-1 zone title_zone: Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Pr""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Jiahang Wu$^{1}$, Taijun Chen$^{1}$, Yingying Wang$^{1}$, Jiafan Bai$^{1}$, Chenwen Lao$^{1}$, Minyue Luo$^{1}$, Mingxia Chen$^{1}$, Wenzhen Peng$^{2}$, Wei Zhi$^{1}$, Jie Weng$^{1}$ and Jianxin Wang$","[65, 333, 1049, 387]",authors,0.8,"[""page-1 zone author_zone: Jiahang Wu$^{1}$, Taijun Chen$^{1}$, Yingying Wang$^{1}$, Ji""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text,"Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; 1992380956@163.com (J.W.","[327, 427, 1110, 538]",affiliation,0.8,"[""page-1 zone affiliation_zone: Key Laboratory of Advanced Technologies of Materials, Minist""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,paragraph_title,check for updates,"[69, 781, 178, 818]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: check for updates""]",section_heading,0.5,body_zone,unknown_like,short_fragment,True,True +1,8,text,"2 Chengdu Yikeda Biotechnology Co., Ltd., Chengdu 610095, China; halishengwu@163.com","[327, 536, 998, 558]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2 Chengdu Yikeda Biotechnology Co., Ltd., Chengdu 610095, Ch""]",affiliation,0.8,body_zone,reference_like,reference_numeric_dot,True,True +1,9,text,"Citation: Wu, J.; Chen, T.; Wang, Y.; Bai, J.; Lao, C.; Luo, M.; Chen, M.; Peng, W.; Zhi, W.; Weng, J.; et al. Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect R","[66, 825, 293, 1038]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Wu, J.; Chen, T.; Wang, Y.; Bai, J.; Lao, C.; Luo,""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,10,text,"Academic Editors: Antonino Morabito and Mike Barbeck +Correspondence: jwang@swjtu.edu.cn; Tel.: +86-28-87634023","[67, 1052, 252, 1097]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic Editors: Antonino Morabito and Mike Barbeck\nCorresp""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,11,text,"g gy g +* Correspondence: jwang@swjtu.edu.cn; Tel.: +86-28-87634023","[327, 558, 795, 580]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: g gy g\n* Correspondence: jwang@swjtu.edu.cn; Tel.: +86-28-87""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,12,image,,"[69, 1313, 185, 1354]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,13,text,Publisher's Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[66, 1197, 307, 1289]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +1,14,text,"Received: 29 March 2022 +Accepted: 9 May 2022 +Published: 18 May 2022","[67, 1113, 227, 1183]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 29 March 2022\nAccepted: 9 May 2022\nPublished: 18 M""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,15,text,"Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66, 1362, 309, 1551]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2022 by the authors. Licensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,16,abstract,Abstract: The lack of vascular tissue and the low metabolism and biological activity of mature chondrocytes lead to the low regeneration ability of articular cartilage. People try to solve this proble,"[327, 608, 1123, 946]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,17,text,Keywords: piezoelectric effect; biomimetic hydrogel; antibacterial; cartilage tissue; tissue regeneration,"[327, 969, 1122, 995]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: piezoelectric effect; biomimetic hydrogel; antibac""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,18,paragraph_title,1. Introduction,"[329, 1069, 473, 1092]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,19,text,"Articular cartilage is one of the connective tissues in the skeletal system. However, due to the fact that cartilage is an avascular tissue, the metabolism and biological activity of mature chondrocyt","[325, 1100, 1124, 1199]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,20,text,"Although the known surgical treatment for cartilage disease has a certain effect, it cannot completely repair the damaged defect. Therefore, to improve the quality of treatment, it is necessary to see","[324, 1200, 1124, 1326]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,21,text,"Because of its good biocompatibility and low immune response, hydrogels are a promising biomaterial for osteochondral tissue engineering. Pulkkinen et al. demonstrated that type II collagen hydrogels ","[324, 1327, 1126, 1554]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,22,footer,"Biomedicines 2022, 10, 1165. https://doi.org/10.3390/biomedicines10051165","[67, 1625, 607, 1647]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,23,footer,https://www.mdpi.com/journal/biomedicines,"[777, 1625, 1122, 1648]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"Biomedicines 2022, 10, 1165","[68, 111, 258, 131]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,2 of 19,"[1068, 111, 1121, 131]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,2,text,"and the surrounding host bone and the same thickness of the new cartilage as that of the host cartilage were realized at 12 weeks postoperatively [3]. However, traditional hydrogels lack the function ","[324, 193, 1124, 493]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"Inspired by the piezoelectric effect of collagen in cartilage tissue [9,10], this work would focus on the design of a biomimetic hydrogel by introducing piezoelectric materials into hydrogel to endow ","[325, 493, 1125, 871]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"Although PVA has been proven to be able to be used in the repair of osteochondral defects in previous work, due to its low biodegradability and bioactivity only pure PVA hydrogel cannot obtain good os","[324, 870, 1125, 1197]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,paragraph_title,2. Materials and Methods 2.1. Materials,"[328, 1217, 569, 1265]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods 2.1. Materials""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,6,footer,,"[329, 1243, 452, 1265]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,7,text,"Sodium chloride (NaCl, >98.0%), Dimethyl sulfoxide (DMSO, >98.0%), Silver nitrate (AgNO₃, 99%), Absolute ethanol (99%), Calcium nitrate tetrahydrate (Ca(NO₃)₂·4H₂O), Ammonium phosphate ((NH₄)₂HPO₄), A","[327, 1274, 1124, 1449]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,paragraph_title,2.2. Preparation of Hydrogels,"[328, 1469, 575, 1494]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Preparation of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +2,9,text,"PVA/PVDF piezoelectric hydrogel was prepared using a two-step method. First, 60 mL DMSO and 40 mL distilled water were mixed into a solvent, and 7.5 g PVA and 7.5 g","[327, 1500, 1124, 1550]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,"Biomedicines 2022, 10, 1165","[68, 111, 258, 131]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header,3 of 19,"[1068, 111, 1121, 131]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,2,text,"PVDF were dissolved in this solvent. The mixture was stirred for 6 h at 92 °C until the suspension solution became homogeneous. Subsequently, the solution was poured into the mold, frozen, and thawed ","[327, 191, 1122, 294]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,2.3. Preparation of Nano-HA,"[328, 312, 572, 337]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Preparation of Nano-HA""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,4,text,"The synthesis of nano-HA was based on the method reported previously [16]. 11.8 g calcium nitrate tetrahydrate (Ca(NO₃)₂·4H₂O) was dissolved in 100 mL DD water, and 3.95 g ammonium phosphate ((NH₄)₂HP","[325, 344, 1125, 570]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,paragraph_title,2.4. Preparation of Silver Nanowires,"[328, 589, 632, 613]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Preparation of Silver Nanowires""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,6,text,"The preparation method of silver nanowires (Ag-NWs) is based on the ethylene glycol system reported previously [17], and the specific operation process is as follows: 70 mL PVP (K30) glycol solution w","[326, 620, 1125, 847]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,paragraph_title,2.5. Preparation of Bi-Layer Hydrogel,"[328, 865, 643, 890]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Preparation of Bi-Layer Hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,8,text,The preparation process of the bi-layer hydrogel is as follows. The preparation method of osteogenic layer and chondrogenic layer is similar to that of single layer hydrogel; 0.6 g of Ag-NWs was added,"[325, 897, 1124, 1100]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,2.6. Characterization of Materials,"[329, 1117, 609, 1141]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Characterization of Materials""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,10,text,"The composite mechanism of the sample was analyzed using a Fourier transform infrared spectrometer (FT-IR, PerkinElmer, Waltham, MA, USA). The compressive stress of the hydrogels was measured by a uni","[326, 1149, 1124, 1503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,header,"Biomedicines 2022, 10, 1165","[68, 111, 258, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,number,4 of 19,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,2,paragraph_title,2.7. Cytocompatibility,"[328, 191, 518, 217]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Cytocompatibility""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,3,text,The cytocompatibility of the hydrogel samples was evaluated through the co-culture of L929 cells with PVA/HA hydrogel and PVA/PVDF/Ag/HA hydrogel. These L929 cells co-cultured with PBS were set as the,"[326, 224, 1124, 399]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,2.8. Hemolysis Assay,"[329, 418, 511, 442]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Hemolysis Assay""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,5,text,"The hydrogel samples with a diameter of 5 mm and a height of 2~3 mm were prepared. The rabbit blood was centrifuged at 1500 rpm for 15 min at 4 °C, rinsed with PBS, and the cycle was repeated three ti","[325, 448, 1125, 755]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,2.9. Degradation Experiment of Hydrogel,"[329, 770, 673, 796]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Degradation Experiment of Hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,7,text,The degradation test was performed in 30 mL PBS (pH = 7.4) or PBS/trypsin solution. The weighed samples were immersed in a certain medium and incubated in a thermostatic bath at 37 °C. At predetermine,"[326, 801, 1126, 979]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,paragraph_title,2.10. Antibacterial Test,"[328, 997, 526, 1020]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. Antibacterial Test""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,9,text,"Gram-positive S. aureus and Gram-negative E. coli were used to evaluate the antibacterial properties of the hydrogel samples. The hydrogel samples with 3~4 mm height, 10 mm diameter were used as the e","[327, 1029, 1125, 1332]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,paragraph_title,2.11. Animal Model and Histological Analysis,"[328, 1349, 713, 1374]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.11. Animal Model and Histological Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,11,text,"All surgical procedures and subsequent animal care were approved by Ethics Committee of State Key Laboratory of Oral Diseases, West China Hospital of Stomatology (Approval Code: SKLODLL2013A86; Approv","[326, 1380, 1124, 1558]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,0,header,"Biomedicines 2022, 10, 1165","[67, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,number,5 of 19,"[1069, 110, 1121, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,2,text,"the rabbit was shaved, sterilized using iodine solution, and draped in a sterile manner, followed by an arthrotomy of the knee joint performed by an anterior medial parapatellar incision, and an opera","[324, 192, 1125, 571]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,figure_title,Table 1. Cartilage Repair Assessment ICRS.,"[327, 593, 681, 619]",table_caption,0.9,"[""table prefix matched: Table 1. Cartilage Repair Assessment ICRS.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +5,4,table,"
ACadhesive capsulitis
CHLcoracohumeral ligament
CMSConstant-Murlay Score
ETLecho-train length
Scoring ItemsIndex ParametersScore
Degree of Defect RepairComplete repair of defect depth4
75% repair o","[330, 626, 1121, 1329]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,5,text,"The H&E staining procedure is briefly described as follows: The tissue sections were incubated in the hematoxylin solution at 37 °C for 5 min, rinsed with water for 1 min to remove excess hematoxylin,","[326, 1360, 1123, 1485]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,text,The toluidine blue staining procedure is briefly described as follows: The tissue sections were incubated in 0.2% toluidine blue solution for 10 min and rinsed with water for 3 s.,"[326, 1486, 1124, 1561]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,0,header,"Biomedicines 2022, 10, 1165","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,number,6 of 19,"[1069, 111, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,2,figure_title,Table 2. Histological scoring system for evaluating osteochondral defects.,"[326, 192, 920, 215]",table_caption,0.9,"[""table prefix matched: Table 2. Histological scoring system for evaluating osteocho""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +6,3,table,"
Scoring ItemsIndex ParametersScore
(a) Overall Defects Evaluation
1. Percent Filling With Newly Formed Tissue","[325, 225, 1123, 1428]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +6,4,paragraph_title,2.12. Statistical Analysis,"[328, 1454, 541, 1480]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.12. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,5,text,"All data are presented as mean ± standard deviation. Student’s test was used to compare the data between two groups, and one-way analysis of variance (ANOVA) was used for statistical tests for compari","[326, 1487, 1124, 1564]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,0,header,"Biomedicines 2022, 10, 1165","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,number,7 of 19,"[1068, 110, 1121, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,2,text,"than 0.05, the difference was considered statistically significant. The displayed error bars represent the standard deviation (SD).","[326, 191, 1122, 243]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,paragraph_title,3. Results and Discussion 3.1. Optimization of PVA/PVDF Hydrogels,"[327, 262, 690, 314]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and Discussion 3.1. Optimization of PVA/PVDF Hydr""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,4,footer,,"[327, 288, 690, 314]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +7,5,text,"For materials used to repair osteochondral defects, we hope that they have certain piezoelectric properties to stimulate the activity of the cells, and that they also have certain mechanical propertie","[323, 320, 1125, 469]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Figure 1A. shows the FT-IR characteristic peaks of PVA and PVDF. For PVA, the peaks at 3337 cm⁻¹, 2943 cm⁻¹ and 1093 cm⁻¹ corresponded to the stretching vibration peak of -OH [18], the asymmetrical st","[323, 469, 1124, 848]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 1A. shows the FT-IR characteristic peaks of PVA and P""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +7,7,chart,,"[346, 868, 688, 1157]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,8,chart,,"[693, 870, 1033, 1150]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,9,chart,,"[335, 1156, 688, 1448]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,10,chart,,"[709, 1155, 1033, 1450]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,11,figure_title,Figure 1. FT-IR analysis and swelling behaviors of the hydrogels. (A) FI-IR spectra of pure PVA and PVDF. (B) FT-IR spectra of PVA/PVDF composite hydrogels. (C) Swelling curves of hydrogels in PBS buf,"[326, 1467, 1123, 1567]",figure_caption,0.92,"[""figure_title label: Figure 1. FT-IR analysis and swelling behaviors of the hydro""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,0,header,"Biomedicines 2022, 10, 1165","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,number,8 of 19,"[1068, 111, 1122, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,2,text,"The piezoelectric experimental results are shown in Figure 2. It can be seen that with the increase in the PVDF content in the hydrogel, the piezoelectric voltage of the materials increased from 0.08 ","[323, 192, 1125, 547]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,chart,,"[167, 567, 450, 791]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,4,chart,,"[454, 572, 740, 789]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,5,chart,,"[741, 573, 1025, 790]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,6,chart,,"[166, 801, 449, 1025]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,7,chart,,"[454, 801, 741, 1027]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,8,chart,,"[745, 797, 1024, 1011]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +8,9,figure_title,Figure 2. Piezoelectric responses of PVA/PVDF composite hydrogels.,"[326, 1046, 887, 1071]",figure_caption,0.92,"[""figure_title label: Figure 2. Piezoelectric responses of PVA/PVDF composite hydr""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,10,text,"Normally, we calculate the swelling rate by the change in mass, which is different from the swelling rate calculated by the change in volume. From the testing results of the swelling rate by the chang","[324, 1088, 1125, 1571]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,0,header,"Biomedicines 2022, 10, 1165","[68, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,9 of 19,"[1069, 110, 1121, 131]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,2,text,capillary adsorption of water. This is why we didn’t observe a significant change in PVA volume during swelling. This means that swelling rate does not play a dominant role in the screening of composi,"[325, 191, 1124, 267]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"Based on the above experimental results, PVA15/PVDF15 hydrogel with good comprehensive properties was selected for the follow-up experimental study. Furthermore, we hoped to endow PVA/PVDF hydrogels w","[326, 267, 1124, 366]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"10 study the effect of Ag-NWs on the piezoelectric property of materials, we first investigated the changes in XRD diffraction peaks before and after adding Ag-NWs. For PVDF, the characteristic peaks ","[326, 365, 1123, 871]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +9,5,display_formula, $$ \mathrm{F}(\beta)=\frac{\mathrm{A}_{\beta}}{\left(\frac{\mathrm{K}_{\beta}}{\mathrm{K}_{\alpha}}\right)\mathrm{A}_{\alpha}+\mathrm{A}_{\beta}} $$ ,"[619, 867, 826, 931]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +9,6,formula_number,(1),"[1095, 879, 1120, 903]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +9,7,text,"In the formula, Aα and Aβ are the absorbance at 766 cm⁻¹ and 840 cm⁻¹, respectively, while Kα and Kβ are the absorption coefficients of α and β phases at the respective wavenumber, which are 6.1 × 10⁴","[327, 942, 1124, 1297]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,8,text,"Referring to the reported research results [22,27], in this study, we chose Ag doping amounts of 0.3%, 0.45%, and 0.6% to investigate the effect of Ag-NWs on piezoelectric properties. After adding Ag-","[326, 1297, 1124, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,0,header,"Biomedicines 2022, 10, 1165","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,10 of 19,"[1062, 110, 1122, 132]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,2,chart,,"[346, 196, 700, 490]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,3,chart,,"[713, 197, 1070, 486]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,4,chart,,"[341, 496, 583, 733]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,5,chart,,"[583, 505, 823, 733]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,6,chart,,"[822, 502, 1071, 735]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,7,figure_title,"Figure 3. (A) XRD patterns of PVA/PVDF and PVA/PVDF/Ag hydrogels. (B) FT-IR spectra of PVA/PVDF and PVA/PVDF/Ag hydrogels. (C–E) Piezoelectric responses of PVA/PVDF hydrogels with 0.3% (C), 0.45% (D),","[327, 747, 1124, 824]",figure_caption,0.92,"[""figure_title label: Figure 3. (A) XRD patterns of PVA/PVDF and PVA/PVDF/Ag hydro""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +10,8,paragraph_title,3.2. Swelling Behaviors of Hydrogels,"[328, 838, 635, 864]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Swelling Behaviors of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +10,9,text,"In order to further allow the composite to better match the cartilage modulus, we used different concentrations of ethanol to dehydrate the composite, adjusted its compression modulus, removed the res","[324, 868, 1125, 1149]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,chart,,"[335, 1169, 707, 1474]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,11,chart,,"[714, 1171, 1097, 1466]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,12,figure_title,"Figure 4. (A) Swelling curves and (B) swelling rates of the PVA/PVDF/Ag composite hydrogels dehydrated with different concentrations of ethanol in PBS buffer solution (37 °C, pH = 7.4).","[327, 1488, 1122, 1540]",figure_caption,0.92,"[""figure_title label: Figure 4. (A) Swelling curves and (B) swelling rates of the ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,0,header,"Biomedicines 2022, 10, 1165","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,number,11 of 19,"[1061, 111, 1122, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,2,paragraph_title,3.3. Rheological Studies of Hydrogels,"[327, 191, 639, 217]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Rheological Studies of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +11,3,text,"The dynamic mechanical properties of PVA15/PVDF15/Ag hydrogels after dehydration using different ethanol concentrations are shown in Figure 5A. In the range of 0.1 to 100 Hz, the hydrogel had a high s","[325, 222, 1125, 551]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,chart,,"[165, 569, 450, 803]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,5,chart,,"[448, 573, 737, 803]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,6,chart,,"[739, 573, 1031, 801]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,7,figure_title,B,"[169, 819, 194, 848]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,8,image,,"[214, 816, 405, 1016]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,9,image,,"[407, 816, 693, 1015]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,10,image,,"[697, 817, 979, 1013]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,11,chart,,"[163, 1030, 443, 1276]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,12,figure_title,D,"[452, 1030, 476, 1057]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,13,chart,,"[449, 1033, 737, 1272]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,14,chart,,"[744, 1029, 1022, 1278]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,15,figure_title,"Figure 5. Dynamic rheology behaviors and mechanical properties of the PVA/PVDF/Ag composite hydrogels. (A) G′, G′′ and tan δ change with frequency. T = 25 °C, strain = 1%. (B) Compression process imag","[323, 1298, 1124, 1452]",figure_caption,0.92,"[""figure_title label: Figure 5. Dynamic rheology behaviors and mechanical properti""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,16,paragraph_title,3.4. Mechanical Properties of Hydrogels,"[328, 1461, 660, 1487]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Mechanical Properties of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +11,17,text,"The compressive property of the materials dehydrated with different ethanol concentrations is shown in Figure 5B–D, which shows typical nonlinear viscoelastic behavior. Therefore, the compressive modu","[326, 1494, 1126, 1570]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,0,header,"Biomedicines 2022, 10, 1165","[67, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,12 of 19,"[1062, 110, 1122, 132]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,2,text,"portion of the stress-strain curve (strain 0–15%). It can be seen that with the increase in ethanol concentration, the compressive modulus of the hydrogel increased from 0.074 MPa to 0.703 MPa, which ","[324, 192, 1123, 418]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,text,"The compression and recovery properties of hydrogel, which were closest to the natural modulus of cartilage. The results showed that after 9 cycles, the compression modulus of the hydrogel was still s","[325, 418, 1125, 594]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,paragraph_title,3.5. Morphology Analysis,"[328, 612, 548, 638]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Morphology Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,5,text,"Figure 6A,B shows the SEM images of silver nanowires and PVA15%/PVDF15%/Ag hydrogels. It can be seen that the length of the Ag-NWs obtained was about 5–15 μm. At the same time, the as-obtained hydroge","[325, 644, 1125, 873]",figure_caption,0.9,"[""figure caption candidate (body narrative): Figure 6A,B shows the SEM images of silver nanowires and PVA""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +12,6,figure_title,A,"[165, 901, 189, 929]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,7,figure_title,B,"[455, 896, 477, 921]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,8,image,,"[166, 896, 1026, 1399]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +12,9,figure_title,C,"[739, 899, 762, 926]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +12,10,figure_title,Figure 6. (A) SEM images of silver nanowires. (B) SEM images of PVA/PVDF/Ag composite hydrogels. (C–F) EDS mapping images of double-layer hydrogel. (C–F) have the same scale as (B).,"[325, 1422, 1120, 1474]",figure_caption,0.92,"[""figure_title label: Figure 6. (A) SEM images of silver nanowires. (B) SEM images""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +12,11,paragraph_title,3.6. Cell Compatibility of Hydrogels,"[327, 1488, 629, 1513]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.6. Cell Compatibility of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,12,text,"Based on the results of compression, piezoelectric and swelling properties of piezoelectric composite hydrogels, we finally chose 70% PVA15/PVDF15/Ag0.3 dehydrated","[326, 1519, 1125, 1571]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,0,header,"Biomedicines 2022, 10, 1165","[67, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,number,13 of 19,"[1062, 110, 1122, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,2,text,"composite hydrogel as the experimental group for subsequent biological evaluation, because its comprehensive properties are best matched with natural cartilage. We then studied the cell compatibility ","[323, 192, 1126, 521]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,image,,"[344, 540, 1092, 1074]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,4,chart,,"[845, 710, 1092, 896]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,5,chart,,"[849, 893, 1092, 1074]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,6,figure_title,"Figure 7. Cytotoxicity and antibacterial properties of PVA/PVDF/HA/Ag composite hydrogels. (A) Proliferative activity of L929 cells co-cultured with PVA/PVDF/HA/Ag composite hydrogels at 1 day, 3 days","[325, 1094, 1126, 1325]",figure_caption,0.92,"[""figure_title label: Figure 7. Cytotoxicity and antibacterial properties of PVA/P""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +13,7,paragraph_title,3.7. Antibacterial Properties of Hydrogels,"[328, 1337, 674, 1362]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.7. Antibacterial Properties of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +13,8,text,"Further, we evaluated the antibacterial properties of piezoelectric composite hydrogels at the macroscopic level by using the plate counting method. Because the plate counting method is better than th","[326, 1369, 1126, 1572]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,0,header,"Biomedicines 2022, 10, 1165","[67, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,1,number,14 of 19,"[1062, 110, 1122, 132]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +14,2,text,"the culture of both Escherichia coli and Staphylococcus aureus. Through quantitative calculation, the inhibition rates of piezoelectric hydrogel on two kinds of bacteria reached over 95%, indicating t","[323, 192, 1125, 470]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,3,paragraph_title,3.8. Hemocompatibility Assay,"[328, 488, 582, 513]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.8. Hemocompatibility Assay""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +14,4,text,"We further used hemolysis to determine the blood compatibility of PVA/HA hydrogel and PVA15/PVDF15/Ag0.3 hydrogel, and the results are shown in Figure 8A,B. It can be seen that both hydrogels had almo","[324, 518, 1124, 672]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,figure_title,A,"[173, 693, 200, 722]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +14,6,chart,,"[203, 692, 594, 1027]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,7,chart,,"[592, 696, 1021, 1022]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,8,chart,,"[165, 1033, 593, 1372]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,9,chart,,"[595, 1036, 1019, 1373]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +14,10,figure_title,"Figure 8. (A) Photos of the hemolysis assay of composite hydrogels. (B) Hemolysis rate of the composite hydrogels. (C,D) Degradation rate of composite hydrogels in PBS buffer solution (pH = 7.4) and i","[326, 1395, 1124, 1473]",figure_caption,0.92,"[""figure_title label: Figure 8. (A) Photos of the hemolysis assay of composite hyd""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +14,11,text,"Figure 8C,D shows the results of in vitro degradation of hydrogel materials. It can be seen that the material basically did not degrade very well in the environment of both PBS buffer (pH = 7.4) and t","[326, 1490, 1124, 1569]",figure_caption,0.9,"[""figure prefix matched: Figure 8C,D shows the results of in vitro degradation of hyd"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +15,0,header,"Biomedicines 2022, 10, 1165","[67, 110, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,header,15 of 19,"[1062, 110, 1122, 132]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +15,2,text,"polymer materials is that water molecules and enzymes cut off the polymer molecular chain, leading to the degradation of the materials [35,36]. In this experiment, the degradation rate of PVA remained","[324, 192, 1125, 368]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,3,paragraph_title,3.9. General Observation and Histological Analysis of Osteochondral Repair,"[327, 387, 954, 412]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.9. General Observation and Histological Analysis of Osteoc""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +15,4,text,"It can be seen from Figure 9A,B that there is still obvious depression in the defect of blank group, and there is basically no repair effect. In the PVA/HA hydrogel group, there was a clear difference","[324, 416, 1125, 848]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,5,figure_title,A,"[166, 893, 184, 915]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,6,figure_title,PVA/HA,"[345, 869, 413, 889]",figure_caption,0.85,"[""figure_title label: PVA/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,7,figure_title,PVA/PVDF/Ag/HA,"[437, 869, 581, 889]",figure_caption,0.85,"[""figure_title label: PVA/PVDF/Ag/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,8,image,,"[168, 868, 574, 1148]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,9,figure_title,B,"[165, 1022, 185, 1044]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,10,figure_title,Blank,"[643, 870, 696, 890]",figure_caption,0.85,"[""figure_title label: Blank""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,11,figure_title,C,"[587, 891, 604, 909]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,12,figure_title,PVA/HA,"[768, 870, 843, 890]",figure_caption,0.85,"[""figure_title label: PVA/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,True,True +15,13,image,,"[598, 882, 739, 1111]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,14,image,,"[744, 892, 880, 1114]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,15,figure_title,D,"[589, 1118, 605, 1137]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,16,figure_title,PVA/PVDF/Ag/HA,"[878, 869, 1033, 891]",figure_caption_candidate,0.85,"[""figure_title label: PVA/PVDF/Ag/HA""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +15,17,chart,,"[163, 1160, 373, 1327]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,18,chart,,"[372, 1160, 586, 1328]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,19,image,,"[596, 1114, 740, 1330]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,20,image,,"[744, 1122, 880, 1328]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,21,image,,"[884, 881, 1027, 1323]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,22,figure_title,"Figure 9. (A) Osteochondral defect model in rabbits. (B) Macroscopic images of knees repaired after 12 weeks (C,D). Histological analysis of the repaired knees after 12 weeks. (C) Toluidine blue stain","[326, 1351, 1126, 1504]",figure_caption,0.92,"[""figure_title label: Figure 9. (A) Osteochondral defect model in rabbits. (B) Mac""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +16,0,header,"Biomedicines 2022, 10, 1165","[68, 111, 259, 132]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,1,header,16 of 19,"[1062, 111, 1122, 132]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +16,2,text,"Further, we evaluated the formation of osteochondral tissues as well as the integration of materials and host tissues at the defects by H&E and toluidine blue staining of histological sections at the ","[323, 191, 1125, 721]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,3,text,"In addition, we measured the size of the implants and found that the height of the implants at 12 weeks after implantation was generally less than that before implantation. We speculated that the redu","[325, 719, 1125, 970]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,4,text,"In general, the piezoelectric-effect-enhanced tissue regeneration ability has been seen, and the piezoelectric-effect-enhanced degradation was also observed in our present PVA material system, showing","[325, 971, 1124, 1072]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,5,paragraph_title,4. Conclusions,"[329, 1091, 471, 1114]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Conclusions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +16,6,text,"In this study, a composite hydrogel with piezoelectric and antibacterial properties was prepared, and these properties were enhanced by introducing silver nanowires. The mechanical and swelling proper","[325, 1120, 1124, 1428]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,0,header,"Biomedicines 2022, 10, 1165","[68, 111, 259, 131]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,1,number,17 of 19,"[1062, 110, 1122, 131]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +17,2,text,"Author Contributions: Conceptualization, J.W. (Jiahang Wu) and J.W. (Jianxin Wang); Formal analysis, J.W. (Jiahang Wu) and Y.W. (Yingying Wang); Funding acquisition, J.W. (Jianxin Wang); Investigation","[325, 194, 1125, 382]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,support_like,none,True,True +17,3,text,Funding: This work was founded by the National Natural Science Foundation of China [No.31370966] and the National Key Technologies R&D Program of China [2016YFC1102001].,"[326, 392, 1124, 440]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,4,text,"Institutional Review Board Statement: The animal study protocol was approved by the Ethics Committee of State Key Laboratory of Oral Diseases, West China Hospital of Stomatology; Approval Code: SKLODL","[326, 451, 1123, 522]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,5,text,Data Availability Statement: Not applicable.,"[328, 533, 695, 557]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,6,text,Acknowledgments: The authors thank the Committee of National Natural Science Foundation of China and the National Key Technologies R&D Program of China for their support. We thank Wenzhen Peng of Chen,"[326, 569, 1123, 640]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,text,"Conflicts of Interest: The Cytocompatibility test platform was kindly provided by Chengdu Yikeda Biotechnology Co., Ltd. (Chengdu, China) All authors acknowledged and decided to publish the results. T","[326, 651, 1122, 722]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False +17,8,paragraph_title,References,"[67, 742, 175, 765]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +17,9,reference_content,"1. 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Xu, Q.Z.; Wang, Y.Y.; Chen, T.J.; Lao, C.W.; Gao, H.K.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,17,reference_content,"30. Korhonen, R.K.; Laasanen, M.S.; Töyräs, J.; Rieppo, J.; Hirvonen, J.; Helminen, H.J.; Jurvelin, J.S. Comparison of the equilibrium response of articular cartilage in unconfined compression, confin","[66, 953, 1123, 1019]",reference_item,0.85,"[""reference content label: 30. Korhonen, R.K.; Laasanen, M.S.; T\u00f6yr\u00e4s, J.; Rieppo, J.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,18,reference_content,"31. Masri, C.; Chagnon, G.; Favier, D. Influence of processing parameters on the macroscopic mechanical behavior of PVA hydrogels. Mater. Sci. Eng. C 2017, 75, 769–776. [CrossRef] [PubMed]","[66, 1022, 1122, 1065]",reference_item,0.85,"[""reference content label: 31. Masri, C.; Chagnon, G.; Favier, D. Influence of processi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,19,reference_content,"32. Kudo, K.; Ishida, J.; Syuu, G.; Sekine, Y.; Ikeda-Fukazawac, T. Structural changes of water in poly(vinyl alcohol) hydrogel during dehydration. J. Chem. Phys. 2014, 140, 044909. [CrossRef] [PubMed","[66, 1068, 1122, 1112]",reference_item,0.85,"[""reference content label: 32. Kudo, K.; Ishida, J.; Syuu, G.; Sekine, Y.; Ikeda-Fukaza""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,20,reference_content,"33. Lok, C.-N.; Ho, C.-M.; Chen, R.; He, Q.-Y.; Yu, W.-Y.; Sun, H.Z.; Kwong-Hang, T.P.; Chiu, J.-F.; Che, C.-M. Proteomic analysis of the mode of antibacterial action of silver nanoparticles. J. Prote","[67, 1114, 1122, 1159]",reference_item,0.85,"[""reference content label: 33. Lok, C.-N.; Ho, C.-M.; Chen, R.; He, Q.-Y.; Yu, W.-Y.; S""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,21,reference_content,"34. Qu, J.; Zhao, X.; Liang, Y.P.; Zhang, T.L.; Ma, P.X.; Guo, B.L. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints ","[67, 1160, 1124, 1226]",reference_item,0.85,"[""reference content label: 34. Qu, J.; Zhao, X.; Liang, Y.P.; Zhang, T.L.; Ma, P.X.; Gu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,22,reference_content,"35. Mawad, D.; Poole-Warren, L.A.; Martens, P.; Koole, L.H.; Slots, T.L.B.; van Hooy-Corstjens, C.S.J. Synthesis and characterization of radiopaque iodine-containing degradable PVA hydrogels. Biomacro","[67, 1228, 1123, 1273]",reference_item,0.85,"[""reference content label: 35. Mawad, D.; Poole-Warren, L.A.; Martens, P.; Koole, L.H.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,23,reference_content,"36. Cao, Y.; Xiong, D.S.; Wang, K.; Niu, Y.X. Semi-degradable porous poly (vinyl alcohol) hydrogel scaffold for cartilage repair: Evaluation of the initial and cell-cultured tribological properties. J","[66, 1275, 1123, 1319]",reference_item,0.85,"[""reference content label: 36. Cao, Y.; Xiong, D.S.; Wang, K.; Niu, Y.X. Semi-degradabl""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,24,reference_content,"37. Wang, H.S.; Klosterhalfen, B.; Müllen, A.; Otto, T.; Dievernich, A.; Jockenhövel, S. Degradation resistance of PVDF mesh in vivo in comparison to PP mesh. J. Mech. Behav. Biomed. 2021, 119, 104490","[66, 1321, 1123, 1365]",reference_item,0.85,"[""reference content label: 37. Wang, H.S.; Klosterhalfen, B.; M\u00fcllen, A.; Otto, T.; Die""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,25,reference_content,"38. Xie, J.H.; Fan, D.D. A high-toughness and high cell adhesion polyvinyl alcohol (PVA-hyaluronic acid (HA)-human-like collagen (HLC) composite hydrogel for cartilage repair. Int. J. Polym. Mater. 20","[67, 1368, 1120, 1412]",reference_item,0.85,"[""reference content label: 38. Xie, J.H.; Fan, D.D. A high-toughness and high cell adhe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,26,reference_content,"39. Damaraju, S.M.; Wu, S.; Jaffe, M.; Arinzeh, T.L. Structural changes in pvdf fibers due to electrospinning and its effect on biological function. Biomed. Mater. 2013, 8, 045007. [CrossRef]","[67, 1414, 1119, 1457]",reference_item,0.85,"[""reference content label: 39. Damaraju, S.M.; Wu, S.; Jaffe, M.; Arinzeh, T.L. Structu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,27,reference_content,"40. Damaraju, S.M.; Shen, Y.; Elele, E.; Khusid, B.; Eshghinejad, A.; Li, J.; Jaffe, M.; Arinzeh, T.L. Three-dimensional piezoelectric fibrous scaffolds selectively promote mesenchymal stem cell diffe","[66, 1460, 1123, 1504]",reference_item,0.85,"[""reference content label: 40. Damaraju, S.M.; Shen, Y.; Elele, E.; Khusid, B.; Eshghin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +19,0,header,"Biomedicines 2022, 10, 1165","[68, 112, 258, 131]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +19,1,header,19 of 19,"[1062, 112, 1122, 131]",noise,0.9,"[""header label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +19,2,reference_content,"41. Jacob, J.; More, N.; Kalia, K.; Kapusetti, G. Piezoelectric smart biomaterials for bone and cartilage tissue engineering. Inflamm. Regen. 2018, 38, 2. [CrossRef] [PubMed]","[68, 195, 1122, 237]",reference_item,0.85,"[""reference content label: 41. Jacob, J.; More, N.; Kalia, K.; Kapusetti, G. Piezoelect""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +19,3,reference_content,"42. Jacob, J.; More, N.; Mounika, C.; Gondaliya, P.; Kalia, K.; Kapusetti, G. The Smart Piezoelectric Nanohybrid of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Barium Titanate for Stimulated Cart","[68, 241, 1124, 306]",reference_item,0.85,"[""reference content label: 42. Jacob, J.; More, N.; Mounika, C.; Gondaliya, P.; Kalia, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/tests/fixtures/ocr_real_papers/A6IC2SIK/block_trace.csv b/tests/fixtures/ocr_real_papers/A6IC2SIK/block_trace.csv new file mode 100644 index 00000000..83e1766e --- /dev/null +++ b/tests/fixtures/ocr_real_papers/A6IC2SIK/block_trace.csv @@ -0,0 +1,287 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,doc_title,Journal Pre-proofs,"[81, 138, 310, 173]",non_body_insert,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,text,Preparation and Properties of Self-Healable and Conductive PVA-Agar Hydrogel with Ultra-high Mechanical Strength,"[79, 229, 756, 290]",authors,0.8,"[""page-1 zone author_zone: Preparation and Properties of Self-Healable and Conductive P""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,2,text,"Xin Xin Sun, Chun Hui Luo, Fa Liang Luo","[80, 318, 469, 346]",authors,0.8,"[""page-1 zone author_zone: Xin Xin Sun, Chun Hui Luo, Fa Liang Luo""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,3,text,PII: S0014-3057(19)32141-X,"[80, 374, 521, 401]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False +1,4,text,DOI: $ \underline{\text{https://doi.org/10.1016/j.eurpolymj.2019.109465}} $,"[81, 405, 728, 432]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: DOI: $ \\underline{\\text{https://doi.org/10.1016/j.eurpolymj""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,5,text,Reference: EPJ 109465,"[82, 435, 405, 462]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False +1,6,text,To appear in: European Polymer Journal,"[81, 492, 539, 520]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False +1,7,image,,"[801, 139, 1071, 504]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,8,text,Received Date: 22 October 2019,"[81, 550, 448, 576]",frontmatter_noise,0.7,"[""frontmatter noise text: Received Date: 22 October 2019""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,9,text,Revised Date: 21 December 2019,"[81, 579, 467, 606]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False +1,10,text,Accepted Date: 27 December 2019,"[80, 609, 467, 637]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Accepted Date: 27 December 2019""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,text,"Please cite this article as: Xin Sun, X., Hui Luo, C., Liang Luo, F., Preparation and Properties of Self-Healable and Conductive PVA-Agar Hydrogel with Ultra-high Mechanical Strength, European Polymer","[79, 683, 1091, 771]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Please cite this article as: Xin Sun, X., Hui Luo, C., Liang""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,12,text,"This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive v","[78, 853, 1094, 1000]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,13,footnote,© 2019 Published by Elsevier Ltd.,"[80, 1079, 393, 1107]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2019 Published by Elsevier Ltd.""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +2,0,header,Journal Pre-proofs,"[493, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,doc_title,Preparation and Properties of Self-Healable and Conductive PVA-Agar Hydrogel with Ultra-high Mechanical Strength,"[205, 160, 985, 257]",paper_title,0.8,"[""page-1 zone title_zone: Preparation and Properties of Self-Healable and Conductive P""]",paper_title,0.8,body_zone,body_like,none,True,True +2,2,text,"Xin Xin Sun $ ^{1} $, Chun Hui Luo $ ^{1,2,3*} $ and Fa Liang Luo $ ^{4,*} $","[327, 271, 861, 299]",authors,0.8,"[""page-1 zone author_zone: Xin Xin Sun $ ^{1} $, Chun Hui Luo $ ^{1,2,3*} $ and Fa Lian""]",authors,0.8,body_zone,body_like,none,True,True +2,3,text,"1College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, Ningxia 750021, China. +*Corresponding Author. Email: luochunhui@iccas.ac.cn.","[174, 305, 983, 360]",affiliation,0.8,"[""page-1 zone affiliation_zone: 1College of Chemistry and Chemical Engineering, North Minzu ""]",affiliation,0.8,frontmatter_side_zone,support_like,none,True,True +2,4,text,"2Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021, Ningxia, China.","[174, 367, 963, 424]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2Key Laboratory of Chemical Engineering and Technology, Stat""]",affiliation,0.8,body_zone,body_like,none,True,True +2,5,text,"3Ningxia Key Laboratory of Solar Chemical Conversion Technology, North Minzu University, Yinchuan 750021, China","[175, 429, 1003, 484]",affiliation,0.8,"[""page-1 zone affiliation_zone: 3Ningxia Key Laboratory of Solar Chemical Conversion Technol""]",affiliation,0.8,body_zone,body_like,none,True,True +2,6,abstract,"4State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Ningxia University, Yinchuan 750021, China. *Corresponding Author. Email: flluo@iccas.ac.cn.","[174, 491, 1013, 550]",frontmatter_support,0.78,"[""first-surviving-page support text: 4State Key Laboratory of High-efficiency Utilization of Coal""]",frontmatter_support,0.78,frontmatter_side_zone,support_like,none,True,True +2,7,abstract,"Abstract: Developing hydrogels with excellent mechanical properties and functions is important and challenging. Herein, commercial available materials, polyvinyl alcohol (PVA) and agar, are used to sy","[173, 557, 1017, 1387]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +2,8,text,Key words: PVA; Agar; high strength; self-healable; electrical conductivity,"[176, 1402, 918, 1433]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,number,1,"[589, 1545, 601, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +3,1,paragraph_title,1. Introduction,"[177, 156, 339, 183]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,2,text,"Human tissues including muscle, skins, cartilage and tendon possess well-defined 3D structure to transfer small molecules and excellent mechanical property to support functions of living organisms. Fo","[173, 203, 1017, 795]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,"To achieve this goal, a variety of biocompatible polymers including poly(hydroxyethyl methacrylate) (PHEMA), poly(ethylene glycol) (PEG), poly(vinylpyrrolidone) (PVP), poly(vinyl alcohol) (PVA), and p","[172, 810, 1017, 1499]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,"Among these biocompatible materials, PVA gels prepared by freezing-thawing (FT)","[175, 1511, 1014, 1542]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,number,2,"[588, 1546, 603, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +4,1,text,"have attracted much attention for their easy operation and non-toxicity [15-16, 18-23]. The crystalline knots served as junctions of PVA network [24-25]. The crystallinity of PVA mainly depends on mol","[173, 157, 1017, 608]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,2,text,"Various approaches have been developed to toughen hydrogels including dual-network hydrogels, nanocomposite hydrogels, topological hydrogel and micellar cross-linked hydrogel [31-34]. Besides the succ","[171, 625, 1018, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,number,3,"[588, 1546, 602, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +5,1,text,"and physical interactions [42], instead of chemical cross-linking, to obtain a tough, functional and self-healable hydrogel with excellent mechanical properties. Agar is a biological polysaccharide wi","[173, 156, 1019, 796]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,2,image,,"[159, 817, 1009, 1281]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,figure_title,Fig.1 Schematic diagram of the synthesis of PVA-Agar-AS hydrogel.,"[297, 1311, 888, 1337]",figure_caption_candidate,0.85,"[""figure_title label: Fig.1 Schematic diagram of the synthesis of PVA-Agar-AS hydr""]",figure_caption,0.85,body_zone,legend_like,none,False,False +5,4,paragraph_title,2. Materials and Methods,"[175, 1404, 446, 1430]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,5,paragraph_title,2.1. Materials,"[176, 1451, 317, 1477]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Materials""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +5,6,text,"Poly(vinyl alcohol) (PVA, Mn=74800 g/mol) and ammonium sulfate (AS, AR) were","[175, 1498, 1014, 1526]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,number,4,"[589, 1546, 602, 1562]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +6,1,text,"purchased from Aladdin Reagent (Shanghai) Co., Ltd. Agar was obtained from Beijing Cool Laibo Technology Co., Ltd. All reagents were used without purification.","[174, 155, 1014, 233]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,2,paragraph_title,2.2. Preparation of PVA-Agar-AS hydrogel,"[174, 249, 605, 278]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Preparation of PVA-Agar-AS hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,3,text,"PVA-Agar-AS hydrogels were synthesized by a combination of FT and soaking methods. Briefly, PVA (1.00 g), different weights (0.10 g, 0.15 g, 0.20 g) of agar and DI water (9.00 g) were put in a vessel.","[173, 294, 1018, 841]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,paragraph_title,2.3. Characterization,"[175, 857, 386, 885]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Characterization""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,5,text,FT-IR spectra were performed on a Thermo Nicolet Avatar 380 Fourier transform infrared spectrometer by the KBr tablet method in the range of 4000-500 cm⁻¹. The SEM images were recorded on a ZEISS EVO1,"[173, 904, 1017, 1264]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,text,The content of water in the hydrogel at different states was calculated according to the formula (1) [49]:,"[175, 1278, 1015, 1356]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,display_formula, $$ X_{n}=\frac{Q_{endo}}{Q_{f}}\times100\% $$ ,"[470, 1368, 662, 1418]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +6,8,formula_number,(1),"[981, 1381, 1011, 1408]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,9,text,Where $ Q_{endo} $ is the melting enthalpy of the sample during the heating process; $ Q_{f}=333.5 $ J/g is the melting enthalpy of pure water [49].,"[174, 1433, 1015, 1512]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,number,5,"[589, 1545, 602, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Journal Pre-proofs,"[492, 98, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +7,1,paragraph_title,2.4. Mechanical testing,"[175, 156, 408, 184]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Mechanical testing""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,2,text,"The mechanical performance of the hydrogel was measured on an electronic testing machine (HZ-1003B, Hengzhun Instrument Technology Co., China) at RT. Before tests, the samples were cut into dumbbells.","[173, 203, 1018, 607]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,3,text,Oscillatory dynamic mechanical measurements were performed on an Anton Paar MCR 302 rheometer equipped with 25 mm parallel plates and a gap of 1.0 mm. The linear viscoelastic (LVE) response region for,"[174, 625, 1017, 983]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,paragraph_title,2.5. Calculation of component content,"[175, 999, 553, 1026]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Calculation of component content""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,5,text,"A gravimetric method was used to measure the content of each component. The water $ (W_{H_2O}) $, gel $ (W_{Gel}) $ and AS contents $ (W_{AS}) $ in the hydrogels were estimated according to the for","[173, 1045, 1016, 1185]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,display_formula, $$ W_{H_{2}O}=\frac{W_{w}-W_{d}}{W_{w}}\times100\% $$ ,"[430, 1195, 678, 1246]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,7,formula_number,(2),"[982, 1210, 1011, 1236]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,8,display_formula, $$ W_{Gel}=\frac{W_{G}\times C_{G}}{W_{w}}\times100\% $$ ,"[431, 1259, 665, 1308]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,9,formula_number,(3),"[982, 1273, 1011, 1298]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,10,display_formula, $$ W_{AS}=\frac{W_{d}-W_{G}\times C_{G}}{W_{w}}\times100\% $$ ,"[430, 1319, 703, 1369]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +7,11,formula_number,(4),"[981, 1335, 1011, 1360]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,12,text,"Where, $ W_{w} $ and $ W_{d} $ are the weight of the wet hydrogel and the dried hydrogel respectively. While $ W_{G} $ is the weight of the wet gel before soaking, and $ C_{G} $ is the mass fracti","[174, 1386, 1014, 1512]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,13,number,6,"[588, 1546, 602, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Journal Pre-proofs,"[492, 98, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +8,1,paragraph_title,2.6. Self-healing property,"[174, 156, 432, 185]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Self-healing property""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,2,text,"The resultant hydrogel was cut into two parts and pressed together in a sealed tube at 90 °C. The self-healing efficiency ( $ E_{H} $) was evaluated by the strain of the pristine ( $ \varepsilon_{b,0}","[173, 202, 1015, 324]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,display_formula," $$ E_{H}=\frac{\varepsilon_{b}}{\varepsilon_{b,0}}\times100\% $$ ","[431, 342, 610, 386]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +8,4,formula_number,(7),"[981, 351, 1012, 378]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,5,paragraph_title,2.7. Conductivity,"[175, 405, 353, 434]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Conductivity""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,6,text,"The hydrogel was connected into an electrical circuit, and the resistances of the hydrogel at different temperatures was recorded and the resistivity ( $ \rho $) was calculated from the formula (8) [5","[174, 451, 1016, 575]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,display_formula, $$ \rho=R/R_{0} $$ ,"[513, 594, 612, 630]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,8,formula_number,(8),"[981, 601, 1011, 628]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,9,text,Where R is the resistances at different temperatures; $ R_{0} $ is the resistance at RT.,"[174, 654, 938, 683]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,citation_line,True,True +8,10,paragraph_title,3. Results and Discussion,"[175, 701, 442, 729]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,11,paragraph_title,3.1. Synthesis and Characterization of Hydrogels,"[175, 748, 657, 777]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Synthesis and Characterization of Hydrogels""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,12,text,"Agar was utilized to form hydrogen bonds with PVA followed by a simple soaking method to enhance these interactions (Fig.1). Firstly, the PVA chains underwent orderly folding, forming crystalline knot","[173, 796, 1017, 1295]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,13,text,"The chemical structures of s-PVA, s-Agar and PVA-Agar-15 precursor hydrogels were characterized by FT-IR. As shown in Fig.2, PVA displays the characteristic peaks at 3370, 1426 and 1096 cm⁻¹ for O-H, ","[173, 1310, 1017, 1528]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,14,number,7,"[589, 1545, 602, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +9,1,text,"bending vibration and C-H of residual carbons of $ \beta $-galactose in Agar [59], respectively. Compared to starting polymers, O-H stretching vibration in PVA-Agar-15 gel shifts to 3320 cm $ ^{-1} $","[173, 156, 1019, 419]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,2,chart,,"[377, 445, 818, 819]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +9,3,figure_title,"Fig.2 FT-IR spectra of s-Agar, s-PVA and PVA-Agar-15 precursor hydrogels.","[261, 842, 926, 868]",figure_caption_candidate,0.85,"[""figure_title label: Fig.2 FT-IR spectra of s-Agar, s-PVA and PVA-Agar-15 precurs""]",figure_caption,0.85,body_zone,legend_like,none,False,False +9,4,paragraph_title,3.2. Mechanical properties,"[175, 889, 441, 917]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Mechanical properties""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +9,5,text,"We first investigated the mechanical strength of PVA-Agar-X precursor hydrogels as a function of agar mass fraction. As shown in Fig.3, the tensile stress ( $ \sigma_{b} $), strain ( $ \varepsilon $),","[171, 935, 1018, 1528]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,number,8,"[588, 1546, 603, 1564]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +10,1,text,"insufficient, while become brittle when they are excessive [38, 62-64].","[175, 156, 858, 184]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,2,chart,,"[236, 205, 588, 492]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,3,chart,,"[597, 206, 986, 491]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,4,figure_title,Fig.3 Tensile (A) and compressive (B) stress-strain curves of PVA-Agar-X hydrogels.,"[227, 507, 963, 534]",figure_caption_candidate,0.85,"[""figure_title label: Fig.3 Tensile (A) and compressive (B) stress-strain curves o""]",figure_caption,0.85,body_zone,legend_like,none,False,False +10,5,text,"Previous works have shown that soaking was a successful strategy to tough hydrogels when network uniformity or crosslink density were improved [17, 38-41]. In the cases of PVA-TA and PVA-PAA composite","[170, 574, 1018, 1546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,number,9,"[588, 1546, 602, 1562]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +11,1,text,"reported PVA gels to date [39, 41].","[175, 155, 519, 184]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,2,figure_title,(A),"[228, 200, 254, 220]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,3,chart,,"[230, 202, 587, 495]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,4,chart,,"[599, 202, 964, 494]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,5,figure_title,Fig.4 Hydrogels with high mechanical properties: Tensile (A) and compressive (B) Stress and strain curves before (PVA-Agar-15) and after (PVA-Agar-15-AS) soaking in AS solution; The inset images show ,"[174, 507, 1016, 629]",figure_caption_candidate,0.85,"[""figure_title label: Fig.4 Hydrogels with high mechanical properties: Tensile (A)""]",figure_caption,0.85,body_zone,legend_like,none,False,False +11,6,figure_title,Table 1. Mechanical properties of hydrogels.,"[400, 663, 789, 689]",table_caption,0.9,"[""table prefix matched: Table 1. Mechanical properties of hydrogels.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,7,table,"
SampleTensileCompressive
Strain (%)Stress (MPa)Young's modulus (MPa)Toughness (MJ/m $ ^{3} $)<","[169, 691, 1010, 1227]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +11,8,vision_footnote, $ ^{*} $ the gel broken at 30% strain,"[202, 1242, 423, 1268]",footnote,0.7,"[""vision_footnote label: $ ^{*} $ the gel broken at 30% strain""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +11,9,text,"The crosslinking density and network homogeneity of physical gels are closely related to the concentration and time of soaking [35-36]. In order to assure uniform network, the effect of soaking time o","[173, 1288, 1016, 1508]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,number,10,"[585, 1544, 608, 1564]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +12,1,text,"saturated AS aqueous solution (~40 wt%) was used to shorten the soaking time. As shown in Fig.5, the tensile strength reach a plateau at 90 min and then decrease after that, where the maximal $ \sigm","[173, 157, 1017, 467]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,2,chart,,"[230, 482, 546, 741]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,3,chart,,"[550, 479, 962, 741]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,4,figure_title,"Fig.5 The effect of soaking time on the tensile properties of PVA-Agar-15-AS hydrogel: (A) Tensile stress-strain curves vs soaking time; (B) Corresponding $ \sigma_{b} $, E and T.","[175, 758, 1014, 814]",figure_caption_candidate,0.85,"[""figure_title label: Fig.5 The effect of soaking time on the tensile properties o""]",figure_caption,0.85,body_zone,legend_like,none,False,False +12,5,paragraph_title,3.3. The energy dissipation mechanism of hydrogel,"[175, 827, 678, 856]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. The energy dissipation mechanism of hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,6,text,We have demonstrated that the mechanical properties increased significantly after soaking in AS solution. But how does this occur? Cyclic loading-unloading experiments were carried out to reveal the e,"[171, 875, 1019, 1512]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,number,11,"[585, 1544, 606, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +13,1,text,"toughness recovery at a 100% strain could reach 56.1% after relaxing at room temperature for 20 min (Fig.S3). However, at a 300% strain, it needs relaxing at 90 °C for 30 min to achieve a recovery rat","[172, 156, 1017, 606]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,2,chart,,"[248, 623, 590, 920]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,3,chart,,"[598, 627, 945, 910]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,4,chart,,"[252, 930, 589, 1222]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,5,chart,,"[597, 928, 946, 1226]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +13,6,figure_title,Fig.6. (A) Loading-unloading curves of PVA-Agar-15-AS hydrogel at the various strains from 100% to 400%; (B) The calculated total and dissipated energy of PVA-Agar-15-AS hydrogel; (C) Fatigue resistan,"[173, 1239, 1029, 1366]",figure_caption_candidate,0.85,"[""figure_title label: Fig.6. (A) Loading-unloading curves of PVA-Agar-15-AS hydrog""]",figure_caption,0.85,body_zone,legend_like,none,False,False +13,7,text,"To gain additional insights into the toughening mechanism, water contents, crosslink density, mesh size, and microstructure of gels were examined [49, 54, 68-70]. Firstly, the water contents were calc","[174, 1388, 1016, 1513]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,8,number,12,"[584, 1544, 607, 1564]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +14,1,text,"the water content of the PVA-Agar-15 precursor hydrogel decreases from 88.5 wt% to 49.7 wt% after soaking in AS aqueous solution for 90 min, accompanied by an increase in polymer mass fraction from 11","[168, 155, 1018, 1221]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,2,number,13,"[585, 1544, 607, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +15,1,chart,,"[246, 174, 584, 433]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,2,chart,,"[597, 176, 944, 457]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,3,figure_title,(C),"[253, 462, 280, 484]",figure_inner_text,0.9,"[""panel label / figure inner text: (C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +15,4,chart,,"[273, 463, 596, 744]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,5,chart,,"[596, 463, 949, 743]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,6,figure_title,"Fig.7. (A) The mass fractions, (B) DSC curves, (C) FT-IR spectra and (D) rheology experiments of PVA-Agar-15 and PVA-Agar-15-AS hydrogels.","[173, 779, 1017, 854]",figure_caption_candidate,0.85,"[""figure_title label: Fig.7. (A) The mass fractions, (B) DSC curves, (C) FT-IR spe""]",figure_caption,0.85,body_zone,legend_like,none,False,False +15,7,text,"In addition, the average molecular weight between adjacent cross-links ( $ \overline{M}_{c} $), crosslinking density ( $ \rho_{c} $), mesh size ( $ \xi $), gel fraction ( $ F_{g} $) and number of effe","[169, 871, 1022, 1513]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,8,number,14,"[584, 1544, 608, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,0,header,Journal Pre-proofs,"[491, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +16,1,text,"respectively. Generally, the rise in $ \rho_c $ and reduce in $ \overline{M}_c/\xi $ indicate the increase in cross-linking density [68, 74], while higher $ v_{\text{exp}} $ suggests fewer imperfec","[173, 155, 1014, 281]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,2,figure_title,Table 2. Network parameters of hydrogels.,"[408, 296, 780, 323]",table_caption,0.9,"[""table prefix matched: Table 2. Network parameters of hydrogels.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +16,3,table,
Sample$ \overline{M}_{c} $(Da)$ \rho_{c} $(mmol/cm $ ^{3} $)$ \xi $ ( $ \mathring{A} $)$ F_{g} $(%)$ v_{exp} $(mol/L)
s-PVA,"[176, 327, 1011, 743]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +16,4,vision_footnote,The network parameters of hydrogels were calculated according Eq. S1&S7 (Supplementary Material),"[178, 753, 923, 778]",footnote,0.7,"[""vision_footnote label: The network parameters of hydrogels were calculated accordin""]",footnote,0.7,body_zone,body_like,none,True,True +16,5,text,"The network structures of gels were further examined by SEM. As shown in Fig.8, the two hydrogels all show a typical honeycomb pore structure [75]. However, the PVA-Agar-15 precursor hydrogel has an u","[173, 822, 1017, 1134]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,figure_title,(A),"[232, 1143, 258, 1164]",figure_inner_text,0.9,"[""panel label / figure inner text: (A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +16,7,image,,"[225, 1139, 594, 1386]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,8,figure_title,(B),"[605, 1143, 628, 1162]",figure_inner_text,0.9,"[""panel label / figure inner text: (B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +16,9,image,,"[598, 1139, 965, 1388]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,10,figure_title,Fig.8. SEM images of (A) PVA-Agar-15 and (B) PVA-Agar-15-AS hydrogels.,"[258, 1400, 929, 1426]",figure_caption_candidate,0.85,"[""figure_title label: Fig.8. SEM images of (A) PVA-Agar-15 and (B) PVA-Agar-15-AS ""]",figure_caption,0.85,body_zone,legend_like,none,False,False +16,11,paragraph_title,3.5. Self-healing property of hydrogel,"[174, 1446, 549, 1475]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Self-healing property of hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +16,12,text,"Due to the dynamic nature of junctions, the hydrogel was expected to display self-","[174, 1493, 1014, 1522]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,13,number,15,"[585, 1544, 607, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +17,1,text,"healing properties [55, 76]. The sample was cut by a razor and pressed together in a sealed tube, then the self-healing behavior of PVA-Agar-15-AS gel was investigated. As presented in Fig. 9, the hea","[172, 155, 1018, 701]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,2,chart,,"[315, 710, 500, 1010]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,3,chart,,"[505, 711, 875, 1011]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,4,figure_title,Fig.9 Illustration of self-healing properties for PVA-Agar-AS DN gel (A) healed gel could load a 2.3 kg weight; (B) Tensile stress-strain curves of the original and healed hydrogel.,"[173, 1022, 1016, 1081]",figure_caption_candidate,0.85,"[""figure_title label: Fig.9 Illustration of self-healing properties for PVA-Agar-A""]",figure_caption,0.85,body_zone,legend_like,none,False,False +17,5,paragraph_title,3.6. Conductivity of hydrogel,"[176, 1122, 469, 1151]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.6. Conductivity of hydrogel""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +17,6,text,"Because of the presence of $ NH_{4}^{+} $, $ SO_{4}^{2-} $ and water in the gel network, we studied the conductivity of PVA-Agar-15 gels upon soaking [36, 77]. As displayed in Fig.10, the red LED la","[172, 1169, 1016, 1530]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,number,16,"[585, 1545, 608, 1564]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,0,header,Journal Pre-proofs,"[492, 98, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +18,1,image,,"[232, 158, 592, 267]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +18,2,image,,"[601, 159, 961, 267]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +18,3,chart,,"[236, 277, 587, 565]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +18,4,chart,,"[602, 278, 959, 568]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +18,5,figure_title,Fig.10 The conductivity photos of (A) PVA-Agar-15 hydrogel and (B) PVA-Agar-15-AS hydrogel; (C) The resistance ratio (R/R₀) of the PVA-Agar-15-AS hydrogel as a function of temperature; (D) The resista,"[173, 584, 1015, 706]",figure_caption_candidate,0.85,"[""figure_title label: Fig.10 The conductivity photos of (A) PVA-Agar-15 hydrogel a""]",figure_caption,0.85,body_zone,legend_like,none,False,False +18,6,paragraph_title,4. Conclusion,"[175, 718, 323, 744]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Conclusion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +18,7,text,"In this work, we demonstrate a universal method based on commercially available sources and simple physical interactions, instead of chemical cross-linking, to obtain a tough, functional and self-heal","[173, 763, 1017, 1123]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,8,paragraph_title,Acknowledgements,"[176, 1131, 384, 1159]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +18,9,text,"The authors appreciate financial support from the National Natural Science Foundation of China (21464001), Innovation Program Fund for Graduate Students of North Minzu University (YCX19116), the East-","[173, 1169, 1016, 1481]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,10,text,The authors declare no competing financial interest.,"[175, 1496, 682, 1526]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,11,number,17,"[585, 1545, 607, 1563]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,0,header,Journal Pre-proofs,"[491, 97, 700, 123]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +19,1,paragraph_title,Reference,"[176, 148, 287, 173]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Reference""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +19,2,reference_content,"[1] Z.G. 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Hoogenboom, Covalen""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +19,19,number,18,"[584, 1545, 607, 1563]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,0,header,Journal Pre-proofs,"[491, 97, 700, 123]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +20,1,reference_content,"Toughness through Secondary Terpyridine Metal-Coordination Crosslinks, Adv. Funct. Mater. (2019) 1904886.","[245, 149, 1012, 203]",reference_item,0.85,"[""reference content label: Toughness through Secondary Terpyridine Metal-Coordination C""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +20,2,reference_content,"[18] M. Kobayashi, J. Toguchida, M. Oka, Preliminary study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus, Biomaterials 24 (2003) 639-647.","[177, 211, 1013, 267]",reference_item,0.85,"[""reference content label: [18] M. Kobayashi, J. Toguchida, M. 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Sci. 272 (1994) 301-309.","[178, 554, 1011, 611]",reference_item,0.85,"[""reference content label: [75] H.H. Trieu, S. Qutubuddin, Polyvinyl alcohol hydrogels ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +23,7,reference_content,"[76] J.J. Cash, T. Kubo, A.P. Bapat, B.S. Sumerlin, Room-Temperature Self-Healing Polymers Based on Dynamic-Covalent Boronic Esters, Macromolecules 48 (2015) 2098-2106.","[178, 617, 1013, 672]",reference_item,0.85,"[""reference content label: [76] J.J. Cash, T. Kubo, A.P. Bapat, B.S. Sumerlin, Room-Tem""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +23,8,reference_content,"[77] D. Gan, L. Han, M. Wang, W. Xing, T. Xu, H. Zhang, K. Wang, L. Fang, X. Lu, Conductive and Tough Hydrogels Based on Biopolymer Molecular Templates for Controlling in Situ Formation of Polypyrrole","[178, 680, 1014, 766]",reference_item,0.85,"[""reference content label: [77] D. Gan, L. Han, M. Wang, W. Xing, T. Xu, H. Zhang, K. W""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +23,9,number,22,"[584, 1544, 607, 1563]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +24,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +24,1,figure_title,Graphical abstract,"[176, 178, 360, 206]",figure_caption_candidate,0.85,"[""figure_title label: Graphical abstract""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +24,2,image,,"[300, 216, 876, 667]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +24,3,chart,,"[308, 412, 588, 665]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +24,4,vision_footnote,Electrical conductivity and Self-healing,"[690, 610, 874, 659]",footnote,0.7,"[""vision_footnote label: Electrical conductivity and Self-healing""]",footnote,0.7,,unknown_like,none,True,True +24,5,number,23,"[584, 1543, 606, 1564]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +25,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +25,1,paragraph_title,Highlights,"[176, 178, 285, 208]",structured_insert,0.7,"[""structured insert label: highlights""]",structured_insert_candidate,0.7,frontmatter_side_zone,heading_like,short_fragment,False,False +25,2,text,• A method from commercially available sources is reported to obtain functional gel.,"[174, 245, 1012, 274]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,False,False +25,3,text,• The tensile strength and toughness of the gel are 18.0 MPa and 42.3 MJ/m $ ^{3} $.,"[175, 283, 952, 312]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,False,False +25,4,text,• The gel is self-healable and conductive,"[176, 323, 603, 351]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,False,False +25,5,text,- This hydrogel might find applications as a biocompatible and bioactive material.,"[175, 362, 999, 392]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,False,False +25,6,number,24,"[584, 1544, 607, 1563]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +26,0,header,Journal Pre-proofs,"[492, 97, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +26,1,paragraph_title,Declaration of interests,"[472, 147, 718, 175]",backmatter_boundary_candidate,0.5,"[""backmatter boundary candidate: Declaration of interests""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True +26,2,text,The authors declare no competing financial interest.,"[176, 210, 682, 240]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +26,3,number,25,"[584, 1543, 607, 1563]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +27,0,header,Journal Pre-proofs,"[492, 98, 699, 123]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +27,1,paragraph_title,Author statement,"[500, 149, 691, 174]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author statement""]",subsection_heading,0.6,,heading_like,short_fragment,True,True +27,2,text,"Chunhui Luo: Conceptualization, Methodology, Resources, Visualization, Supervision, Project administration, Funding acquisition, Writing - Review & Editing +Xinxin Sun: Software, Validation, Formal ana","[175, 177, 1013, 293]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +27,3,text,Faliang Luo: Review & Editing,"[177, 273, 498, 301]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +27,4,number,26,"[584, 1544, 607, 1564]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/A8E7SRVS/block_trace.csv b/tests/fixtures/ocr_real_papers/A8E7SRVS/block_trace.csv index 59119900..323805ce 100644 --- a/tests/fixtures/ocr_real_papers/A8E7SRVS/block_trace.csv +++ b/tests/fixtures/ocr_real_papers/A8E7SRVS/block_trace.csv @@ -1,42 +1,45 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default 1,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrhD3i3D0OdRyi7TvSFi4Ci3iVC4/OAVpDDa8KKGKv0Ymy+78= on 01/20/2024","[19, 269, 55, 930]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,none,False,True +wCX1AWnYQp/llQrhD3i3D0OdRyi7TvSFi4Ci3iVC4/OAVpDDa8KKGKv0Ymy+78= on 01/20/2024","[19, 269, 55, 930]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_main_zone,support_like,none,False,False 1,1,header,"Clin Orthop Relat Res (2023) 481:1158-1170 DOI 10.1097/CORR.0000000000002520","[99, 79, 433, 123]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,2,header,"Clinical Orthopaedics and Related Research $ ^{®} $ A Publication of The Association of Bone and Joint Surgeons $ ^{®} $","[795, 52, 1069, 124]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,3,text,Clinical Research,"[112, 143, 282, 168]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False -1,4,doc_title,High Acromial Slope and Low Acromiohumeral Distance Increase the Risk of Retear of the Supraspinatus Tendon After Repair,"[98, 221, 1069, 298]",paper_title,0.6,"[""page-1 frontmatter title guard: High Acromial Slope and Low Acromiohumeral Distance Increase""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True -1,5,text,"Thomas Caffard Dr med¹, Desdemona Kralewski Dr med¹, Marius Ludwig Dr med¹, Daniel Dornacher PD Dr med¹, Michael Fuchs PD Dr med¹, Thomas Kappe Prof Dr med¹, Heiko Reichel Prof Dr med¹, Mirco Sgroi PD","[96, 329, 910, 403]",unknown_structural,0.8,"[""page-1 zone author_zone: Thomas Caffard Dr med\u00b9, Desdemona Kralewski Dr med\u00b9, Marius ""]",authors,0.8,frontmatter_main_zone,support_like,none,False,True +1,4,doc_title,High Acromial Slope and Low Acromiohumeral Distance Increase the Risk of Retear of the Supraspinatus Tendon After Repair,"[98, 221, 1069, 298]",paper_title,0.8,"[""page-1 zone title_zone: High Acromial Slope and Low Acromiohumeral Distance Increase""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Thomas Caffard Dr med¹, Desdemona Kralewski Dr med¹, Marius Ludwig Dr med¹, Daniel Dornacher PD Dr med¹, Michael Fuchs PD Dr med¹, Thomas Kappe Prof Dr med¹, Heiko Reichel Prof Dr med¹, Mirco Sgroi PD","[96, 329, 910, 403]",authors,0.8,"[""page-1 zone author_zone: Thomas Caffard Dr med\u00b9, Desdemona Kralewski Dr med\u00b9, Marius ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True 1,6,text,Received: 21 July 2022 / Accepted: 15 November 2022 / Published online: 20 December 2022,"[98, 500, 710, 522]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 21 July 2022 / Accepted: 15 November 2022 / Publis""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False 1,7,text,Copyright © 2022 by the Association of Bone and Joint Surgeons,"[98, 522, 530, 542]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright \u00a9 2022 by the Association of Bone and Joint Surgeo""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False 1,8,paragraph_title,Abstract,"[99, 602, 183, 624]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True 1,9,abstract,"Background Retearing of the supraspinatus (SSP) tendon after repair is relatively common, but its cause is rarely clear. Although the role of acromion morphology and glenoid orientation in the pathoge","[97, 626, 568, 793]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True -1,10,abstract,Questions/purposes (1) Is acromial morphology associated with the risk of retear after SSP tendon repair? (2) Is there an association between inclination and version of the glenoid and the odds for re,"[99, 795, 569, 916]",unknown_structural,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,,unknown_like,none,False,True -1,11,footnote,"Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest","[98, 996, 569, 1096]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Each author certifies that there are no funding or commercia""]",frontmatter_noise,0.8,frontmatter_side_zone,support_like,none,False,False -1,12,text,patients who had intact cuff repairs and those who had retears?,"[599, 626, 1070, 674]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True -1,13,footnote,All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research $ ^{\circledR} $ editors and board members are on file with the publication and can be viewed on request,"[98, 1096, 570, 1298]",footnote,0.7,"[""footnote label: All ICMJE Conflict of Interest Forms for authors and Clinica""]",footnote,0.7,frontmatter_side_zone,support_like,none,True,True +1,10,abstract,Questions/purposes (1) Is acromial morphology associated with the risk of retear after SSP tendon repair? (2) Is there an association between inclination and version of the glenoid and the odds for re,"[99, 795, 569, 916]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,11,footnote,"Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest","[98, 996, 569, 1096]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Each author certifies that there are no funding or commercia""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False +1,12,text,patients who had intact cuff repairs and those who had retears?,"[599, 626, 1070, 674]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,body_like,none,True,True +1,13,footnote,All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research $ ^{\circledR} $ editors and board members are on file with the publication and can be viewed on request,"[98, 1096, 570, 1298]",footnote,0.7,"[""footnote label: All ICMJE Conflict of Interest Forms for authors and Clinica""]",footnote,0.7,body_zone,support_like,none,True,True 1,14,text,"Methods Between August 2012 and December 2015, we treated 92 patients for SSP tendon tears; all of these patients were considered for inclusion in the present study. We considered patients with comple","[598, 674, 1073, 1417]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -1,15,footnote," $ ^{1} $Department of Orthopaedic Surgery, RKU, University of Ulm, Ulm, Germany","[99, 1327, 567, 1371]",footnote,0.7,"[""footnote label: $ ^{1} $Department of Orthopaedic Surgery, RKU, University o""]",footnote,0.7,,unknown_like,affiliation_marker,True,True -1,16,footnote,"M. Sgroi ✉, Oberer Eelsberg 45, DE-89081 Ulm, Germany, Email: sgroi.mirco@yahoo.de","[98, 1388, 567, 1431]",footnote,0.7,"[""footnote label: M. Sgroi \u2709, Oberer Eelsberg 45, DE-89081 Ulm, Germany, Email""]",footnote,0.7,,unknown_like,none,True,True -1,17,footer_image,,"[102, 1472, 267, 1501]",non_body_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,,unknown_like,empty,False,False -1,18,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1148, 1563]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +1,15,footnote," $ ^{1} $Department of Orthopaedic Surgery, RKU, University of Ulm, Ulm, Germany","[99, 1327, 567, 1371]",footnote,0.7,"[""footnote label: $ ^{1} $Department of Orthopaedic Surgery, RKU, University o""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True +1,16,footnote,"M. Sgroi ✉, Oberer Eelsberg 45, DE-89081 Ulm, Germany, Email: sgroi.mirco@yahoo.de","[98, 1388, 567, 1431]",footnote,0.7,"[""footnote label: M. Sgroi \u2709, Oberer Eelsberg 45, DE-89081 Ulm, Germany, Email""]",footnote,0.7,body_zone,body_like,none,True,True +1,17,footer_image,,"[102, 1472, 267, 1501]",non_body_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,False +1,18,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1148, 1563]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 2,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsH04XMl0hCy -wCX1AWnYQp/llQrHD3I3D0OdRyi7TvSF14Ci3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 268, 55, 931]",non_body_insert,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,none,False,False +wCX1AWnYQp/llQrHD3I3D0OdRyi7TvSF14Ci3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 268, 55, 931]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False 2,1,header,"Volume 481, Number 6","[101, 80, 278, 101]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False 2,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583, 80, 998, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 2,3,number,1159,"[1029, 81, 1069, 100]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False 2,4,text,"same two observers using the Sugaya and Castricini classifications, accounting for atrophy and fatty degeneration of the SSP muscle. To assess interobserver reliability, the two observers took measure","[96, 141, 570, 736]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,5,text,"Results After controlling for potentially confounding variables such as acromioplasty or preoperative fatty infiltration as well as muscle atrophy, the only morphological parameters associated with a ","[96, 739, 569, 1382]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,6,text,"Conclusion The preoperative acromiohumeral interval and acromial slope are associated with SSP tendon rupture after repair. Conversely, the critical shoulder angle, acromial tilt, lateral acromial ang","[98, 1382, 569, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,7,text,,"[599, 142, 1072, 544]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,7,text,"rerupture after repair. Conversely, the critical shoulder +angle, acromial tilt, lateral acromial angle, and acromial +index had no association with the postoperative outcome. +Additionally, glenoid incl","[599, 142, 1072, 544]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,8,text,"Level of Evidence Level III, therapeutic study.","[601, 546, 984, 571]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False 2,9,paragraph_title,Introduction,"[601, 618, 721, 641]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True 2,10,text,"Despite great scientific interest, the pathogenesis of supraspinatus (SSP) reruptures after repair has not been determined [12, 25]. The acromion's morphology and glenoid orientation have been postula","[597, 666, 1074, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,11,footer_image,,"[904, 1471, 1071, 1502]",non_body_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,False +2,11,footer_image,,"[904, 1471, 1071, 1502]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 2,12,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1149, 1565]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 3,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMI0hCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Ci3Vc4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19, 267, 55, 931]",non_body_insert,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,False +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Ci3Vc4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19, 267, 55, 931]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 3,1,number,1160,"[102, 80, 143, 101]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,2,header,Caffard et al.,"[172, 80, 271, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[737, 79, 1070, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False @@ -53,21 +56,24 @@ wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Ci3Vc4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[ 3,14,text,"Two experienced shoulder surgeons (TK and MS), who were not involved in the radiologic examinations, performed the arthroscopic procedures. The surgeons were senior surgeons who specialize in shoulder","[598, 187, 1072, 1173]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,15,paragraph_title,Aftercare,"[601, 1216, 687, 1241]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Aftercare""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 3,16,text,"After the surgical procedure, the operated-on arm was immobilized in an abduction pillow (Ultra Sling III) for 6 weeks. The patients were allowed to perform passive exercises for 6 weeks. Then, the pi","[598, 1264, 1072, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,17,footer_image,,"[101, 1472, 267, 1501]",non_body_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,False +3,17,footer_image,,"[101, 1472, 267, 1501]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 3,18,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1148, 1564]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 4,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMl0hCy -wCX1AWnYQp/llQrHD3l3D0OdRyi7TvSF14Cf3Vc4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 266, 55, 936]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3l3D0OdRyi7TvSF14Cf3Vc4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 266, 55, 936]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 4,1,header,"Volume 481, Number 6","[101, 80, 278, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 4,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583, 80, 998, 103]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 4,3,number,1161,"[1029, 80, 1068, 101]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -4,4,figure_title,Table 1. Demographic data and preoperative tendon quality of the investigated patients (n = 55),"[98, 138, 568, 183]",table_caption_candidate,0.9,"[""table prefix matched: Table 1. Demographic data and preoperative tendon quality of""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,4,figure_title,Table 1. Demographic data and preoperative tendon quality of the investigated patients (n = 55),"[98, 138, 568, 183]",table_caption,0.9,"[""table prefix matched: Table 1. Demographic data and preoperative tendon quality of""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 4,5,table,"
ParameterValue
Women, % (n)51 (28)
Side involved, right, % (n)67 (37)
Age in years, mean $ \pm $ SD
Type 1Sufficient thickness of the tendon, tendon continuity preserved, homogeneous low signal intensity
Type 2Sufficient thickness of the tendon, with","[600, 170, 1070, 513]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 6,14,paragraph_title,Sugaya Classification,"[601, 735, 783, 760]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Sugaya Classification""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 6,15,text,"To assess the tendon’s integrity, we applied the Sugaya classification (Table 2). In a recent study by Hasegawa et al. [16], the Sugaya classification showed good to excellent (kappa = 0.68 to 0.91) i","[598, 782, 1072, 1025]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -115,18 +124,21 @@ wCX1AWnYQp/llQrHD3i3D0OdRyI7TvSFi4Ci3iVC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024"," 6,20,footer_image,,"[903, 1471, 1071, 1502]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 6,21,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1538, 1149, 1563]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 7,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMl0hCy -wCX1AWnYQp/llQrHD3i3D0OdRy17TvSF14Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[18, 268, 55, 930]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRy17TvSF14Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[18, 268, 55, 930]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 7,1,number,1164,"[102, 80, 143, 100]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 7,2,header,Caffard et al.,"[172, 80, 270, 101]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 7,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[738, 79, 1070, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -7,4,figure_title,Table 3. Castricini classification [5],"[99, 138, 365, 160]",table_caption_candidate,0.9,"[""table prefix matched: Table 3. Castricini classification [5]""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +7,4,figure_title,Table 3. Castricini classification [5],"[99, 138, 365, 160]",table_caption,0.9,"[""table prefix matched: Table 3. Castricini classification [5]""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 7,5,table,
Signal intensityIHigher signal intensity throughout the whole tendon thickness
IIFocal increase of signal intensity
VariableAdjusted OR (95% CI)p value
Acromial slope1.4 (1.1 to 1.8)< 0.01
Acromiohumeral distance0.9 (0.,"[99, 1006, 565, 1221]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 8,10,text,"The model achieved statistical significance in four steps (p < 0.001). Concomitant subscapularis reconstruction, tenodesis of the long head of the biceps tendon, lateral clavicula resection, and acrom","[97, 1232, 569, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,11,text,,"[598, 140, 1073, 502]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,11,text,"(95% CI 54 to 98), specificity of 76 (95% CI 60 to 88) +and 62 (95% CI 46 to 76), an OR of 11 (95% CI 2 to 46) +and 9 (95% CI 1.8 to 46), and area under the curve of +0.82 (95% CI 0.6 to 0.9) and 0.73 (95","[598, 140, 1073, 502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,12,paragraph_title,Glenoid Morphology and Retear Risk,"[600, 546, 912, 570]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Glenoid Morphology and Retear Risk""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 8,13,text,"There was no difference between patients with intact SSP tendons and those with reruptured SSP tendons in terms of glenoid inclination ( $ 6^\circ \pm 4^\circ $ versus $ 6^\circ \pm 3^\circ $, mean d","[600, 593, 1071, 740]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,14,paragraph_title,Clinical Outcome,"[601, 784, 752, 809]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical Outcome""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True @@ -155,69 +170,76 @@ wCX1AVNYQp/llQrHD3i3D0OdRy17TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[ 8,18,footer_image,,"[903, 1470, 1071, 1502]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 8,19,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1149, 1565]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 9,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 267, 55, 930]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 267, 55, 930]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 9,1,number,1166,"[102, 81, 143, 100]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 9,2,header,Caffard et al.,"[172, 80, 271, 101]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 9,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[737, 79, 1070, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -9,4,figure_title,Table 5. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[98, 137, 1035, 184]",table_caption_candidate,0.9,"[""table prefix matched: Table 5. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,4,figure_title,Table 5. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[98, 137, 1035, 184]",table_caption,0.9,"[""table prefix matched: Table 5. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 9,5,table,
VariableSugaya 1 to 3Sugaya 4 and 5Mean difference (95% CI)p value
AHI in mm83 $ \pm $ 2061 $ \pm $ 162,"[95, 187, 1070, 378]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 9,6,vision_footnote,Data are presented as the mean ± SD. SSP = supraspinatus tendon; AHI = acromiohumeral interval; CSA = critical shoulder angle; AS = acromial slope; AT = acromial tilt; LAA = lateral acromial angle; AI,"[99, 387, 1071, 433]",footnote,0.7,"[""vision_footnote label: Data are presented as the mean \u00b1 SD. SSP = supraspinatus ten""]",footnote,0.7,body_zone,body_like,none,True,True 9,7,paragraph_title,Limitations,"[99, 468, 197, 492]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Limitations""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 9,8,text,"First, in most instances, the analyzed patients underwent mild acromioplasty. Because the probability of suffering a retear of the SSP tendon was evaluated using parameters before acromioplasty, the m","[95, 516, 571, 829]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,9,chart,,"[115, 866, 551, 1280]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -9,10,figure_title,Fig. 6 The figure represents the receiver operating characteristic curve of the acromiohumeral interval and acromial slope. The coordinates on the curve determined the cutoff values for identifying a ,"[97, 1299, 570, 1432]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 6 The figure represents the receiver operating characte""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +9,10,figure_title,Fig. 6 The figure represents the receiver operating characteristic curve of the acromiohumeral interval and acromial slope. The coordinates on the curve determined the cutoff values for identifying a ,"[97, 1299, 570, 1432]",figure_caption,0.92,"[""figure_title label: Fig. 6 The figure represents the receiver operating characte""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 9,11,text,"technique were included. In our opinion, this criterion was important because if patients who had undergone a different reconstructive technique for the SSP had been included, this could have affected","[598, 467, 1072, 994]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,12,text,"Fourth, because the preoperative MRI examinations were performed before the start of this study, standardization of imaging techniques was not possible a priori. This is a limitation of the present st","[598, 994, 1074, 1427]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,13,footer_image,,"[101, 1472, 267, 1501]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 9,14,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1149, 1564]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 10,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 267, 55, 930]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 267, 55, 930]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 10,1,header,"Volume 481, Number 6","[100, 80, 278, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 10,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583, 80, 999, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 10,3,number,1167,"[1029, 80, 1069, 100]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -10,4,figure_title,"Table 6. Sensitivity, specificity, likelihood ratio, OR, and AUC of acromial slope and acromiohumeral distance","[97, 138, 920, 160]",table_caption_candidate,0.9,"[""table prefix matched: Table 6. Sensitivity, specificity, likelihood ratio, OR, and""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,4,figure_title,"Table 6. Sensitivity, specificity, likelihood ratio, OR, and AUC of acromial slope and acromiohumeral distance","[97, 138, 920, 160]",table_caption,0.9,"[""table prefix matched: Table 6. Sensitivity, specificity, likelihood ratio, OR, and""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 10,5,table,"
VariableAcromiohumeral distance (95% CI)Acromial slope (95% CI)
Sensitivity, %77 (46 to 95)85 (54 to 98)
Specificit","[99, 164, 1070, 305]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 10,6,vision_footnote,AUC = area under the curve.,"[98, 313, 321, 337]",footnote,0.7,"[""vision_footnote label: AUC = area under the curve.""]",footnote,0.7,body_zone,body_like,none,True,True 10,7,text,"resolution. However, we do not have a 3.0 Tesla MRI in our department; this reflects the situation in most clinics and therefore does not seem to be a major limitation.","[95, 373, 568, 444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,8,text,"Sixth, residents performed the measurements. Because of their inexperience, they may have produced imprecise results. To avoid this, both observers underwent training before the measurements, during w","[95, 445, 572, 1117]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,9,text,,"[598, 372, 1072, 615]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,9,text,"have biased the assessment of the influence of acromial +morphology and glenoid orientation, so we do not consider +this limitation detracts from our findings. Finally, in the +present study, one of the tw","[598, 372, 1072, 615]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,10,paragraph_title,Acromial Morphology and Retear Risk,"[600, 659, 922, 684]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Acromial Morphology and Retear Risk""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 10,11,text,"We found that of the acromial morphologic measures analyzed, only acromial slope and acromiohumeral distance were associated with a higher risk of recurrence 2 years after SSP repair. The critical sho","[598, 706, 1073, 1118]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,12,figure_title,Table 7. Clinical and radiologic outcomes depending on the AHI cutoff,"[98, 1155, 642, 1178]",table_caption_candidate,0.9,"[""table prefix matched: Table 7. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,12,figure_title,Table 7. Clinical and radiologic outcomes depending on the AHI cutoff,"[98, 1155, 642, 1178]",table_caption,0.9,"[""table prefix matched: Table 7. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 10,13,table,"","[96, 1177, 1069, 1400]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 10,14,vision_footnote,AHI = acromiohumeral interval; WORC = Western Ontario Rotator Cuff Index.,"[98, 1406, 682, 1431]",footnote,0.7,"[""vision_footnote label: AHI = acromiohumeral interval; WORC = Western Ontario Rotato""]",footnote,0.7,body_zone,body_like,none,True,True 10,15,footer_image,,"[904, 1470, 1071, 1502]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 10,16,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1149, 1565]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 11,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMl0hCy -wCX1AWnYQp/llQrHD3i3D0OdRyj7TvSFI4Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19, 265, 56, 930]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyj7TvSFI4Cf3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[19, 265, 56, 930]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False 11,1,number,1168,"[101, 80, 144, 100]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 11,2,header,Caffard et al.,"[171, 80, 271, 101]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 11,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[737, 79, 1070, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False -11,4,figure_title,Table 8. Clinical and radiologic outcomes depending on the AS cutoff,"[97, 138, 635, 160]",table_caption_candidate,0.9,"[""table prefix matched: Table 8. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,4,figure_title,Table 8. Clinical and radiologic outcomes depending on the AS cutoff,"[97, 138, 635, 160]",table_caption,0.9,"[""table prefix matched: Table 8. Clinical and radiologic outcomes depending on the A""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 11,5,table,"
VariableAHI ≤ 7.4 mmAHI $ > $ 7.4 mmp value
WORC, mean $ \pm $ SD97 $ \pm $ 2.697 $ \pm $ 2.20.56
VariableAS ≤ 24.5°AS > 24.5°p value
WORC, mean $ \pm $ SD97 $ \pm $ 2.397 $ \pm $ 2.60.84
O","[95, 160, 1069, 385]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 11,6,vision_footnote,"AS = acromial slope; WORC = Western Ontario Rotator Cuff Index,","[97, 389, 600, 415]",footnote,0.7,"[""vision_footnote label: AS = acromial slope; WORC = Western Ontario Rotator Cuff Ind""]",footnote,0.7,body_zone,body_like,none,True,True 11,7,text,that a higher critical shoulder angle is associated with a higher risk of full-thickness retears of the rotator cuff at shorter follow-up intervals. Another study reported that a critical shoulder ang,"[95, 471, 571, 1026]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 11,8,paragraph_title,Glenoid Morphology and Retear Risk,"[99, 1070, 409, 1096]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Glenoid Morphology and Retear Risk""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 11,9,text,We found that glenoid orientation in terms of inclination and version was not associated with radiologic outcomes after SSP repair. Glenoid orientation could impact the forces acting on the reconstruc,"[97, 1117, 570, 1216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -11,10,text,,"[597, 472, 1073, 1217]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True -11,11,figure_title,Table 9. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[97, 1263, 1037, 1309]",table_caption_candidate,0.9,"[""table prefix matched: Table 9. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,10,text,"according to our results, surgeons do not need to measure +glenoid morphology preoperatively because it does not +appear to play a predictive role in rerupture of the SSP. A +study compared repaired SSP ","[597, 472, 1073, 1217]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,figure_title,Table 9. Comparison between patients with an intact SSP and those with a reruptured SSP regarding preoperative acromial morphology and glenoid orientation,"[97, 1263, 1037, 1309]",table_caption,0.9,"[""table prefix matched: Table 9. Comparison between patients with an intact SSP and ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 11,12,table,
VariableSugaya Groups 1 to 3Sugaya Groups 4 and 5Mean difference (95% CI)p value
GV in $ \circ $$ -2 \pm 3 $$ -3 ,"[100, 1311, 1070, 1401]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 11,13,vision_footnote,SSP = supraspinatus tendon; GV = glenoidal version; GI = glenoidal inclination.,"[98, 1407, 698, 1431]",footnote,0.7,"[""vision_footnote label: SSP = supraspinatus tendon; GV = glenoidal version; GI = gle""]",footnote,0.7,body_zone,body_like,none,True,True 11,14,footer_image,,"[100, 1471, 268, 1502]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True 11,15,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1538, 1148, 1565]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,support_like,none,False,False 12,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbslHo4XMlOhCy -wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 267, 55, 930]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[19, 267, 55, 930]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 12,1,header,"Volume 481, Number 6","[100, 80, 278, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 12,2,header,SSP Rerupture and Acromial and Glenoidal Morphology,"[583, 80, 999, 102]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 12,3,number,1169,"[1029, 81, 1069, 100]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -12,4,figure_title,Table 10. Postoperative clinical outcomes depending on SSP integrity,"[98, 138, 633, 160]",table_caption_candidate,0.9,"[""table prefix matched: Table 10. Postoperative clinical outcomes depending on SSP i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +12,4,figure_title,Table 10. Postoperative clinical outcomes depending on SSP integrity,"[98, 138, 633, 160]",table_caption,0.9,"[""table prefix matched: Table 10. Postoperative clinical outcomes depending on SSP i""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 12,5,table,
VariableSugaya Groups 1 to 3Sugaya Groups 4 and 5Mean difference (95% CI)p value
WORC in points98 $ \pm $ 297 $ ,"[99, 165, 1070, 252]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 12,6,vision_footnote,Data are presented as the mean ± SD. SSP = supraspinatus tendon; WORC = Western Ontario Rotator Cuff Index.,"[98, 262, 956, 285]",footnote,0.7,"[""vision_footnote label: Data are presented as the mean \u00b1 SD. SSP = supraspinatus ten""]",footnote,0.7,body_zone,body_like,none,True,True 12,7,paragraph_title,Clinical Outcome Depending on Retear of the SSP,"[98, 321, 513, 345]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Clinical Outcome Depending on Retear of the SSP""]",subsection_heading,0.6,body_zone,heading_like,none,True,True -12,8,text,We found no difference in clinical outcome between patients with intact and reruptured SSP tendons and no association with preoperative glenoid morphology and orientation. These results are important ,"[95, 368, 571, 968]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True +12,8,text,We found no difference in clinical outcome between patients with intact and reruptured SSP tendons and no association with preoperative glenoid morphology and orientation. These results are important ,"[95, 368, 571, 968]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 12,9,paragraph_title,Conclusion,"[100, 1015, 198, 1037]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True -12,10,text,"We found that acromiohumeral distance and acromial slope are associated with the risk of retear of the SSP tendon after repair. In addition, we observed no association of glenoid inclination and gleno","[97, 1061, 571, 1424]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,11,text,,"[599, 321, 1069, 370]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +12,10,text,"We found that acromiohumeral distance and acromial slope are associated with the risk of retear of the SSP tendon after repair. In addition, we observed no association of glenoid inclination and gleno","[97, 1061, 571, 1424]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,11,text,"studies might investigate whether more-radical acromioplasty +can reduce the risk of rerupture of the SSP in these patients.","[599, 321, 1069, 370]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 12,12,paragraph_title,References,"[602, 392, 708, 415]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True 12,13,reference_content,"1. Ames JB, Horan MP, Van der Meijden OAJ, Leake MJ, Millett PJ. Association between acromial index and outcomes following arthroscopic repair of full-thickness rotator cuff tears. J Bone Joint Surg A","[611, 425, 1071, 504]",reference_item,0.85,"[""reference content label: 1. Ames JB, Horan MP, Van der Meijden OAJ, Leake MJ, Millett""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 12,14,reference_content,"2. Balke M, Schmidt C, Dedy N, Banerjee M, Bouillon B, Liem D. Correlation of acromial morphology with impingement syndrome and rotator cuff tears. Acta Orthop. 2013;84:178-183.","[612, 505, 1069, 564]",reference_item,0.85,"[""reference content label: 2. Balke M, Schmidt C, Dedy N, Banerjee M, Bouillon B, Liem ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True @@ -237,7 +259,7 @@ wCX1AWnYQp/llQrHD3i3D0OdRyi7TvSF14Cf3VC4/OAVpDDa8KKGKVOYmy+78= on 01/20/2024","[ 12,28,footer_image,,"[904, 1471, 1071, 1502]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,tail_nonref_hold_zone,unknown_like,empty,False,True 12,29,footer,Copyright © 2022 by the Association of Bone and Joint Surgeons. Unauthorized reproduction of this article is prohibited.,"[1, 1539, 1149, 1565]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,support_like,none,False,False 13,0,aside_text,"Downloaded from http://journals.lww.com/clinorthop by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCy -wCX1AWnYQp/llQrhD3i3D0OdRyj7TvSFI4Ci3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[20, 268, 54, 931]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,none,False,True +wCX1AWnYQp/llQrhD3i3D0OdRyj7TvSFI4Ci3VC4/OAVpDDa8KKGKV0Ymy+78= on 01/20/2024","[20, 268, 54, 931]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False 13,1,number,1170,"[102, 81, 142, 100]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False 13,2,header,Caffard et al.,"[172, 81, 270, 101]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False 13,3,header,Clinical Orthopaedics and Related Research $ ^{\circledR} $,"[738, 81, 1069, 101]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/CAQNW9Q2/block_trace.csv b/tests/fixtures/ocr_real_papers/CAQNW9Q2/block_trace.csv index 80768a75..f7878723 100644 --- a/tests/fixtures/ocr_real_papers/CAQNW9Q2/block_trace.csv +++ b/tests/fixtures/ocr_real_papers/CAQNW9Q2/block_trace.csv @@ -2,9 +2,9 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,0,number,268,"[113, 68, 146, 87]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False 1,1,header,Annals of the Rheumatic Diseases 1994; 53: 268–275,"[740, 66, 1108, 88]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,2,paragraph_title,REVIEW,"[112, 135, 218, 162]",frontmatter_noise,0.8,"[""page-1 article-type label: review""]",frontmatter_noise,0.8,frontmatter_main_zone,heading_like,short_fragment,False,False -1,3,doc_title,Quantitative radiography of osteoarthritis,"[315, 202, 963, 242]",paper_title,0.6,"[""page-1 frontmatter title guard: Quantitative radiography of osteoarthritis""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,3,doc_title,Quantitative radiography of osteoarthritis,"[315, 202, 963, 242]",paper_title,0.8,"[""page-1 zone title_zone: Quantitative radiography of osteoarthritis""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True 1,4,text,J C Buckland-Wright,"[312, 289, 504, 315]",authors,0.6,"[""page-1 initial-lastname author byline: J C Buckland-Wright""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True -1,5,footer,"Division of Anatomy and Cell Biology, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, United Kingdom J C Buckland-Wright","[112, 1346, 298, 1493]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +1,5,footer,"Division of Anatomy and Cell Biology, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, United Kingdom J C Buckland-Wright","[112, 1346, 298, 1493]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 1,6,text,"Radiography is important in the diagnosis of osteoarthritis (OA) as the features described in the pathology of the disease can be visualised, with joint space narrowing generally thought to reflect ca","[313, 357, 706, 916]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,7,text,"Scoring systems, although an essential and widely used method for assessing disease progression, suffer from a number of limitations. They are based on two assumptions, first that the change in any on","[313, 916, 706, 1383]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,8,footnote,"Correspondence to: @@ -14,20 +14,24 @@ Cell Biology, UMDS, Guy's Hospital, London Bridge, London SE1 9RT, -United Kingdom.","[114, 1496, 275, 1610]",frontmatter_support,0.75,"[""page-1 correspondence footnote: Correspondence to:\nDr J C Buckland-Wright,\nDivision of Anato""]",frontmatter_support,0.75,frontmatter_side_zone,support_like,none,True,True -1,9,text,Quantitative assessments of the structural changes in peripheral joints with OA are based on measurements of distance and area in the radiographic image. Such measurements are obtained either directly,"[314, 1382, 706, 1610]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Quantitative assessments of the structural changes in periph""]",frontmatter_noise,0.8,,body_like,none,False,False -1,10,text,,"[718, 358, 1112, 662]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True -1,11,paragraph_title,Standard radiography,"[720, 700, 932, 722]",unknown_structural,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Standard radiography""]",section_heading,0.5,frontmatter_side_zone,heading_like,none,False,True +United Kingdom.","[114, 1496, 275, 1610]",frontmatter_support,0.75,"[""page-1 correspondence footnote: Correspondence to:\nDr J C Buckland-Wright,\nDivision of Anato""]",frontmatter_support,0.75,body_zone,body_like,none,True,True +1,9,text,Quantitative assessments of the structural changes in peripheral joints with OA are based on measurements of distance and area in the radiographic image. Such measurements are obtained either directly,"[314, 1382, 706, 1610]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Quantitative assessments of the structural changes in periph""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,10,text,"results of their application in quantifying +disease progression are outlined. Where it has +been possible to obtain precise measurements +of changes in x ray features, this has provided +new insight into","[718, 358, 1112, 662]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: results of their application in quantifying\ndisease progress""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,11,paragraph_title,Standard radiography,"[720, 700, 932, 722]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Standard radiography""]",section_heading,0.5,body_zone,heading_like,none,True,True 1,12,text,"The radiographic image is a shadow of the differential absorption of x rays by the tissues of the joint, where radiographic appearance of bony structures appears white to light grey and the radio-tran","[718, 722, 1112, 851]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,13,text,"Advantages Standard radiography is simple, cheap, easily accessible and well understood. The radiographs provide a permanent record which can be assessed at any stage during the disease process permit","[719, 850, 1112, 1022]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 1,14,text,Limitations The relatively large size of the x ray source of standard x ray tubes (usually 1 mm and at best 0·3 mm in diameter) demands that the object is placed close to the x ray plate resulting in ,"[719, 1022, 1112, 1298]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -1,15,text,"Apart from those investigators who have developed special stereotaxic devices for examining leg alignment $ ^{11,12} $ or knee joint motion, $ ^{13} $ there is no accepted method for positioning a joi","[719, 1298, 1114, 1609]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Apart from those investigators who have developed special st""]",frontmatter_noise,0.8,,unknown_like,none,False,False +1,15,text,"Apart from those investigators who have developed special stereotaxic devices for examining leg alignment $ ^{11,12} $ or knee joint motion, $ ^{13} $ there is no accepted method for positioning a joi","[719, 1298, 1114, 1609]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Apart from those investigators who have developed special st""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False 2,0,header,Quantitative radiography of OA,"[88, 62, 310, 84]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False 2,1,number,269,"[1057, 61, 1089, 79]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False 2,2,image,,"[294, 111, 1087, 755]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -2,3,figure_title,"Figure 1 Standard radiographic appearance of osteoarthritic knee joints showing different degrees of joint space narrowing, subchondral sclerosis and osteophytes. The antero-posterior radiographs of t","[287, 770, 1088, 842]",figure_caption_candidate,0.92,"[""figure_title label: Figure 1 Standard radiographic appearance of osteoarthritic ""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +2,3,figure_title,"Figure 1 Standard radiographic appearance of osteoarthritic knee joints showing different degrees of joint space narrowing, subchondral sclerosis and osteophytes. The antero-posterior radiographs of t","[287, 770, 1088, 842]",figure_caption,0.92,"[""figure_title label: Figure 1 Standard radiographic appearance of osteoarthritic ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 2,4,text,reliable assessment of joint space loss. The absence of any standards in the radio-anatomical positioning of joints results in variable radiographic images of a joint both within and between patients ,"[288, 867, 685, 1613]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,5,text,"but more often than not the plane of measurement is never defined. Further, no account is taken of the distance between the centre of the joint and the x ray film. Where this is fairly large, as in an","[694, 866, 1092, 1364]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,5,text,"but more often than not the plane of measurement is never defined. Further, no account is taken of the distance between the centre of the joint and the x ray film. Where this is fairly large, as in an","[694, 866, 1092, 1364]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: but more often than not the plane of measurement is never de""]",frontmatter_noise,0.8,frontmatter_side_zone,body_like,none,False,False 2,6,paragraph_title,Quantitative standard radiography,"[697, 1402, 1027, 1423]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Quantitative standard radiography""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 2,7,text,"Quantitative standard radiography has been applied primarily to joint space width (JSW) measurements in OA of the hip and knee, since assessment of articular cartilage thickness is important in evalua","[696, 1421, 1092, 1613]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,0,number,270,"[116, 66, 149, 86]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -35,7 +39,11 @@ United Kingdom.","[114, 1496, 275, 1610]",frontmatter_support,0.75,"[""page-1 co 3,2,text,"standardisation of the position of the hip and knee and reproducible repositioning of the joints on successive examinations. $ ^{12} $ $ ^{24} $ However, in these studies JSW measurements were carried","[315, 124, 708, 381]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,3,text,"In the former, Martel's group at Michigan University, undertook to define the precision of hyaline cartilage thickness measurements. $ ^{24} $ They used a small sourced x ray tube (0·3 mm focal spot) ","[314, 380, 708, 1237]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,4,text,The development of microcomputers and image analysis technique has provided the means of obtaining an accurate and reproducible method for measuring changes in joint anatomy and for handling large amo,"[313, 1237, 707, 1613]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -3,5,text,,"[719, 126, 1116, 728]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +3,5,text,"Joint space is assessed automatically using an +edge detection technique and is expressed +either as the mean width of several repeat +measures or as the joint space area. The +reproducibility of the comp","[719, 126, 1116, 728]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,6,paragraph_title,Microfocal radiography,"[722, 766, 948, 789]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Microfocal radiography""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 3,7,text,Microfocal x ray units are characterised by an extremely small x ray source (<15 µm in diameter) which allows radiographs to be taken at high magnification with very fine detail recorded in the film. ,"[720, 788, 1113, 1025]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 3,8,text,"Advantages of microfocal radiography are those characteristic of an extremely small x ray source. Large object magnifications are obtained ranging from ×2 to ×20, although, macroradiographs are more u","[719, 1027, 1114, 1611]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -43,13 +51,17 @@ United Kingdom.","[114, 1496, 275, 1610]",frontmatter_support,0.75,"[""page-1 co 4,1,number,271,"[1059, 58, 1090, 77]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 4,2,image,,"[95, 114, 677, 425]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True 4,3,image,,"[95, 433, 681, 736]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -4,4,figure_title,"Figure 2 Part of the macroradiographs of osteoarthritic knee joints with medial compartment involvement, in the weight bearing standing A) and loaded tunnel B) views. In the medial compartment the ant","[92, 753, 681, 840]",figure_caption_candidate,0.92,"[""figure_title label: Figure 2 Part of the macroradiographs of osteoarthritic knee""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +4,4,figure_title,"Figure 2 Part of the macroradiographs of osteoarthritic knee joints with medial compartment involvement, in the weight bearing standing A) and loaded tunnel B) views. In the medial compartment the ant","[92, 753, 681, 840]",figure_caption,0.92,"[""figure_title label: Figure 2 Part of the macroradiographs of osteoarthritic knee""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 4,5,text,"resolution, makes it possible to detect structural detail virtually at the histological level $ ^{34} $ and to carry out direct accurate measurement of the x ray features characteristic of arthritis w","[295, 865, 687, 973]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,6,text,Limitations are also a function of the small x ray source size. The smallness of the source limits the output of an x ray tube and results in longer exposure times. This restriction has been largely o,"[295, 972, 688, 1122]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,7,text,Care and accuracy are needed in positioning the patient in relation to the source. This requires specially developed apparatus enabling the patient to keep still and to maintain the position of their ,"[295, 1121, 689, 1380]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,8,paragraph_title,Standardisation of macroradiographic procedure,"[296, 1417, 656, 1459]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Standardisation of macroradiographic procedure""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 4,9,text,"Stereotaxic devices are used to position each patient accurately and reproducibly. The centre of the joint under examination (the middle phalanx in the hand, the joint space in the knee and the femora","[295, 1459, 689, 1607]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,10,text,,"[698, 113, 1095, 588]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,10,text,"knee radiography an image intensifier and +camera are used to screen the joint to ensure +that the tibial plateau is flat and parallel to the +central ray of the x ray beam and perpendicular +to the x ray","[698, 113, 1095, 588]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,11,text,The anatomical sites within the macroradiograph used in defining the boundaries for the measurement of a feature are described precisely. Steroscopic examination of the macroradiographs identified the,"[700, 586, 1094, 757]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,12,text,Femur: the distal convex margin of the condyle (fig 2).,"[703, 758, 1093, 800]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,13,text,"Tibia, medial compartment: a line extending from near the tibial spine to the medial or outer margin, across the centre of the floor of the articular fossa in the mid-coronal plane of the joint. This ","[701, 800, 1096, 1249]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -61,11 +73,15 @@ United Kingdom.","[114, 1496, 275, 1610]",frontmatter_support,0.75,"[""page-1 co 5,4,paragraph_title,Joint space width,"[313, 585, 480, 607]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Joint space width""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True 5,5,text,Joint space narrowing is considered the most important radiological feature of OA but its accuracy in measuring true cartilage loss has been questioned. $ ^{16} $ To overcome this problem we carried o,"[311, 608, 706, 906]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,6,text,"In patients with early, but definite OA of the hand, JSW measurements showed that 56% of the patients had an increase in the interbone distance compared with the reference value obtained from healthy ","[313, 906, 706, 1058]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -5,7,text,,"[717, 117, 1112, 419]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +5,7,text,"wrist and hand joints, showed a significant +increase at the first carpo-metacarpal joint of +the wrist and in the proximal interphalangeal +joints of these patients.39 This feature appears +to represent ","[717, 117, 1112, 419]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,8,paragraph_title,"Relationship between changes in joint space, subchondral sclerosis and osteophytes","[717, 456, 1072, 521]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Relationship between changes in joint space, subchondral scl""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 5,9,text,The results of the studies of OA of the hand $ ^{38} $ and knee $ ^{45} $ showed that the extent of subchondral sclerosis and osteophytosis was significantly advanced in these joints in over half of t,"[717, 521, 1114, 1059]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,10,image,,"[324, 1090, 1102, 1539]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True -5,11,figure_title,"Figure 3 Part of a macroradiograph of the metacarpo-phalangeal joints of a patient with hand OA, showing the mineralised cartilage zone extending into the existing articular cartilage space, contribut","[316, 1548, 1053, 1601]",figure_caption_candidate,0.92,"[""figure_title label: Figure 3 Part of a macroradiograph of the metacarpo-phalange""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +5,11,figure_title,"Figure 3 Part of a macroradiograph of the metacarpo-phalangeal joints of a patient with hand OA, showing the mineralised cartilage zone extending into the existing articular cartilage space, contribut","[316, 1548, 1053, 1601]",figure_caption,0.92,"[""figure_title label: Figure 3 Part of a macroradiograph of the metacarpo-phalange""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 6,0,header,Quantitative radiography of OA,"[93, 67, 315, 89]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False 6,1,number,273,"[1061, 68, 1093, 86]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,2,text,"cartilage, measured as joint space narrowing, is a late stage phenomenon of osteoarthritis.","[294, 124, 686, 168]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -73,7 +89,11 @@ United Kingdom.","[114, 1496, 275, 1610]",frontmatter_support,0.75,"[""page-1 co 6,4,text,"Evaluation of the pattern of joint space narrowing in the OA hand patients, during the study, showed no association between this feature and the pattern of normal force distribution in the hand, descr","[292, 465, 686, 959]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,5,text,"The results of these investigations show that by using accurate and precise radiographic procedures and methods of measurement, it is possible to detect early OA and to evaluate its severity and progr","[290, 957, 685, 1214]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,6,text,"The greater sensitivity of this technique, compared with standard radiography, has improved the chances of measuring the effect of a 'disease modifying' agent, particularly in patients with radiologic","[287, 1213, 683, 1614]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -6,7,text,,"[700, 124, 1096, 363]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +6,7,text,"just the signal or most painful knee, but also +the contra-lateral since nearly all of these joints +were found to be painful with clear radio- +pathological evidence of early OA; patients +with marked jo","[700, 124, 1096, 363]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,8,paragraph_title,Increasing the accuracy and reproducibility in standard radiography,"[700, 403, 1075, 447]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Increasing the accuracy and reproducibility in standard radi""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 6,9,footer,,"[700, 426, 1075, 447]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False 6,10,text,"As described above, quantitative microfocal radiography can measure progression, in hand and knee OA, within a reasonably short period of time, providing information on the natural history of the dise","[698, 441, 1093, 917]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -84,8 +104,8 @@ United Kingdom.","[114, 1496, 275, 1610]",frontmatter_support,0.75,"[""page-1 co 7,1,header,Buckland-Wright,"[986, 71, 1104, 91]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False 7,2,text,analysis and overall reduce the time taken for the mensural procedures.,"[310, 127, 699, 173]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,3,paragraph_title,Conclusion,"[310, 212, 423, 233]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True -7,4,text,"To measure OA progression, it is necessary to establish a universally acceptable method for accurate and reproducible and quantitative assessment of changes in joint structure. This will require more ","[310, 235, 701, 705]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True -7,5,text,"I wish to express my gratitude to Dr Charles Hutton for inviting me to write this article and to numerous colleagues who have collaborated in our studies in osteoarthritis, in particular Dr Diana Macf","[312, 721, 702, 827]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +7,4,text,"To measure OA progression, it is necessary to establish a universally acceptable method for accurate and reproducible and quantitative assessment of changes in joint structure. This will require more ","[310, 235, 701, 705]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"I wish to express my gratitude to Dr Charles Hutton for inviting me to write this article and to numerous colleagues who have collaborated in our studies in osteoarthritis, in particular Dr Diana Macf","[312, 721, 702, 827]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,6,reference_content,"1 Resnick D, Niwayama G. Degenerative diseases of extra-spinal locations. In: Resnick D, Niwayama G, eds. Diagnosis of bone and joint disorders, 2nd ed. Philadelphia: Saunders, 1988: 1365–479.","[323, 882, 700, 939]",reference_item,0.85,"[""reference content label: 1 Resnick D, Niwayama G. Degenerative diseases of extra-spin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 7,7,reference_content,"2 Altman R, Asch E, Block D, et al. Development of criteria for the classification and reporting of osteoarthritis. Arthritis Rheum 1986; 29: 1039–49.","[322, 939, 700, 982]",reference_item,0.85,"[""reference content label: 2 Altman R, Asch E, Block D, et al. Development of criteria ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 7,8,reference_content,"3 Altman R, Fries J F, Bloch D A, et al. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum 1987; 30: 1214–25.","[322, 982, 701, 1025]",reference_item,0.85,"[""reference content label: 3 Altman R, Fries J F, Bloch D A, et al. Radiographic assess""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True diff --git a/tests/fixtures/ocr_real_papers/DAB9VMWW/block_trace.csv b/tests/fixtures/ocr_real_papers/DAB9VMWW/block_trace.csv new file mode 100644 index 00000000..8699f7af --- /dev/null +++ b/tests/fixtures/ocr_real_papers/DAB9VMWW/block_trace.csv @@ -0,0 +1,264 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,RESEARCH ARTICLE,"[98, 53, 358, 82]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header_image,,"[1036, 1, 1191, 28]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,2,header,"ADVANCED MATERIALS +www.advmat.de","[934, 44, 1098, 117]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,3,doc_title,"Capacitive-Coupling-Responsive Hydrogel Scaffolds +Offering Wireless In Situ Electrical Stimulation Promotes +Nerve Regeneration","[95, 147, 1039, 282]",paper_title,0.8,"[""page-1 zone title_zone: Capacitive-Coupling-Responsive Hydrogel Scaffolds\nOffering W""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,4,text,"Ping Wu, Chao Xu, Xianghui Zou, Kun Yang, Yanping Xu, Xueyao Li, Xiaokun Li,* +Zhouguang Wang,* and Zhiqiang Luo*","[96, 314, 1005, 386]",authors,0.8,"[""page-1 zone author_zone: Ping Wu, Chao Xu, Xianghui Zou, Kun Yang, Yanping Xu, Xueyao""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,abstract,"Electrical stimulation (ES) has shown beneficial effects in repairing injured tissues. However, current ES techniques that use tissue-traversing leads and bulky external power suppliers have significa","[97, 446, 739, 946]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,6,paragraph_title,1. Introduction,"[766, 435, 914, 461]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,7,text,"Electrical stimulation (ES) has shown significant benefits in the repair and regeneration of damaged tissues including nerves, muscles, skin, bones, tendons, and ligaments. $ ^{[1]} $ In particular, i","[763, 472, 1099, 1065]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,8,text,"feasible. $ ^{[6]} $ Therefore, there is an urgent need to explore wireless ES without external bulky power sources and percutaneous leads for tissue-engineering applications.","[606, 1066, 1098, 1132]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,9,footnote,"P. Wu, C. Xu, X. Zou, K. Yang, Y. Xu, X. Li, Z. Luo +National Engineering Research Center for Nanomedicine +College of Life Science and Technology +Huazhong University of Science and Technology +Wuhan 430","[96, 1071, 572, 1356]",footnote,0.7,"[""footnote label: P. Wu, C. Xu, X. Zou, K. Yang, Y. Xu, X. Li, Z. Luo\nNational""]",footnote,0.7,body_zone,body_like,none,True,True +1,10,text,"To avoid invasive percutaneous leads during in vivo ES, implantable mini-sized devices that can generate electrical currents to assist in tissue regeneration have been explored. For example, Yin et al","[606, 1132, 1099, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,11,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202310483,"[98, 1375, 587, 1415]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,12,footer,DOI: 10.1002/adma.202310483,"[97, 1420, 339, 1443]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,13,footer,"Adv. Mater. 2024, 36, 2310483","[98, 1487, 277, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,14,number,2310483 (1 of 10),"[530, 1484, 665, 1507]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,15,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 338, 116]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header_image,,"[928, 44, 1092, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +2,2,image,,"[116, 167, 1072, 773]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,3,figure_title,"Figure 1. Schematics of wireless electrical stimulation based on conductive and biodegradable hydrogels for spinal cord repair. Owing to the capacitive coupling configuration, the electrostatic induct","[89, 785, 1095, 938]",figure_caption,0.92,"[""figure_title label: Figure 1. Schematics of wireless electrical stimulation base""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,4,text,"by an external magnetic field, and the ES delivered to the cuff electrodes wrapped around the damaged sciatic nerve facilitates peripheral nerve regeneration. Despite these advances, the application o","[89, 981, 582, 1179]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,We speculate that an electroactive biomaterial capable of functioning both as a biodegradable regeneration scaffold and wireless ES platform could overcome the aforementioned challenges. In this situa,"[90, 1180, 581, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"gel scaffold with capacitive-coupling wireless electrical gener- +ation capability for successful spinal cord injury (SCI) repair +(Figure 1). The biodegradable conductive scaffold was composed +of a chito","[600, 980, 1093, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,footer,"Adv. Mater. 2024, 36, 2310483","[93, 1487, 271, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,8,number,2310483 (2 of 10),"[524, 1484, 658, 1507]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,9,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,10,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header_image,,"[934, 44, 1097, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +3,2,figure_title,a,"[127, 159, 147, 181]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,3,image,,"[140, 159, 346, 355]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,b,"[355, 152, 373, 181]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,5,image,,"[377, 165, 577, 355]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,C,"[589, 157, 608, 181]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,7,image,,"[611, 172, 816, 359]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,8,figure_title,d,"[838, 154, 859, 181]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,9,chart,,"[836, 175, 1075, 382]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,10,figure_title,e,"[128, 372, 150, 393]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,11,figure_title,f,"[355, 366, 371, 394]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,12,chart,,"[120, 388, 361, 586]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,13,chart,,"[350, 376, 596, 590]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,14,figure_title,g,"[582, 372, 602, 399]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,15,figure_title,h,"[842, 367, 862, 395]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,16,chart,,"[586, 387, 826, 587]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,17,chart,,"[832, 396, 1082, 587]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,18,chart,,"[113, 589, 352, 801]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,19,chart,,"[362, 594, 837, 807]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,20,chart,,"[841, 593, 1070, 805]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,21,figure_title,Figure 2. Fabrication and characterization of CS/Gel/BP conductive hydrogels. a) TEM image of BP nanosheet. b) AFM image of BP nanosheet. c) SEM image of dehydrated CS/Gel/BP hydrogel. d) Rheological ,"[96, 817, 1101, 952]",figure_caption,0.92,"[""figure_title label: Figure 2. Fabrication and characterization of CS/Gel/BP cond""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,22,text,enhancing neural regeneration and the regeneration of other tissues.,"[95, 982, 587, 1027]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,23,paragraph_title,2. Results and Discussion,"[96, 1054, 350, 1078]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Results and Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +3,24,text,"Biodegradable conductive hydrogels provide a conductive microenvironment that enhances the repair of electroactive tissues.[11] In this study, we explored a wireless ES strategy based on biodegradable","[95, 1091, 588, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,25,text,"(BP) nanosheets have been explored as conductive dopants for +constructing conductive hydrogels for neural tissue-engineering +applications.[14] BP nanosheets possess excellent biocompatibil- +ity and bi","[605, 981, 1099, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,26,footer,"Adv. Mater. 2024, 36, 2310483","[98, 1487, 277, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,27,number,2310483 (3 of 10),"[530, 1484, 664, 1508]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,28,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,29,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155, 32, 1171, 1536]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +4,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header_image,,"[928, 44, 1091, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +4,2,text,"located at 1156 and 1067 cm⁻¹, which can be assigned to the P=O and P−O oxygen functionalities, respectively, resulting from the surface oxidation of BP. Moreover, the peaks between ≈1280 and ≈1510 cm","[89, 148, 582, 325]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"After mixing the BP@PDA nanosheets evenly in the chitosan/gelatin solution, a stable composite chitosan/gelatin/black phosphorus (CS/Gel/BP) hydrogel (BCH) was formed by adding the crosslinking agent ","[89, 331, 583, 1246]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,text,Capacitive coupling technology is a promising near-field coupling approach for wireless power transfer developed for consumer electronics and vehicles.[16] To avoid complicated device construction usi,"[89, 1245, 582, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,"responsive hydrogel scaffold with alternating current flow dur- +ing high-frequency charging and discharging can function as an +electroactive biomaterial for tissue engineering applications. The +CS/Gel/B","[598, 149, 1092, 655]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,text,"Before investigating the in vitro NSC behavior on a conductive CS/Gel/BP hydrogel with electrostatic induction-driven in situ ES, the biocompatibility of the BCH was studied. A cell contact assay was ","[600, 654, 1093, 1094]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"To evaluate the effect of electrostatic-induction-driven in situ WES on cell proliferation, the cell growth density of NSCs on the CS/Gel/BP hydrogels was determined using Ki67 immunofluorescence stai","[599, 1094, 1093, 1443]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,footer,"Adv. Mater. 2024, 36, 2310483","[93, 1487, 271, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,9,footer,2310483 (4 of 10),"[524, 1484, 658, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,10,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,11,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[97, 45, 346, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header_image,,"[934, 44, 1097, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,body_like,empty,False,True +5,2,image,,"[123, 149, 332, 513]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,3,chart,,"[319, 157, 500, 332]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,4,chart,,"[523, 166, 666, 330]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,chart,,"[684, 167, 832, 330]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,chart,,"[348, 336, 500, 495]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,7,chart,,"[840, 166, 1070, 343]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,chart,,"[520, 337, 666, 505]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,9,chart,,"[685, 337, 841, 500]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,10,chart,,"[845, 348, 1073, 532]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,11,image,,"[113, 528, 447, 859]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,12,image,,"[455, 527, 629, 858]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,13,image,,"[629, 547, 776, 857]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,image,,"[778, 551, 925, 857]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,15,image,,"[925, 550, 1079, 858]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,16,chart,,"[113, 866, 362, 1069]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,17,chart,,"[352, 865, 583, 1058]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,18,chart,,"[584, 864, 825, 1057]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,19,figure_title,k,"[118, 1051, 138, 1077]",figure_inner_text,0.9,"[""panel label / figure inner text: k""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,20,chart,,"[830, 861, 1077, 1059]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,21,figure_title,m,"[582, 1055, 609, 1078]",figure_inner_text,0.9,"[""panel label / figure inner text: m""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,22,chart,,"[121, 1082, 356, 1244]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,23,figure_title,n,"[826, 1055, 847, 1078]",figure_inner_text,0.9,"[""panel label / figure inner text: n""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,24,chart,,"[356, 1082, 583, 1245]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,25,chart,,"[590, 1081, 831, 1244]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,26,chart,,"[838, 1079, 1075, 1244]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,27,figure_title,"Figure 3. BCH with wireless in situ ES promotes NSC proliferation, differentiation, and neurotrophic factor secretion. a) Schematic of wireless electrical stimulation (WES) for NSC regulation. b,c) Ef","[96, 1251, 1099, 1406]",figure_caption,0.92,"[""figure_title label: Figure 3. BCH with wireless in situ ES promotes NSC prolifer""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,28,footer,"Adv. Mater. 2024, 36, 2310483","[99, 1487, 276, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,29,number,2310483 (5 of 10),"[530, 1484, 664, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,30,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,31,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1542]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 338, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +6,1,header_image,,"[929, 45, 1091, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +6,2,text,"in situ ES on NSC differentiation was also investigated. After 7 d of WES, with 20 min of treatment per day, immunofluorescence staining for Tuj1, a neural marker for neuron-specific microtubule eleme","[90, 149, 582, 805]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +6,3,text,"To investigate in vivo therapeutic effect of the wireless ES generated by the capacitive-coupling-responsive CS/Gel/BP hydrogel, an SCI model with a completely transected T9 segment was established us","[90, 807, 583, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +6,4,text,"2.75 V. Therefore, the in vivo and in vitro coupling efficiency for +power transmission appears to be similar.","[601, 148, 1092, 193]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,heading_numbered,True,True +6,5,text,"The effect of the BCH combined with electrostatic-induction-driven WES in promoting locomotor functional recovery was evaluated using Basso–Beattie–Bresnahan (BBB) locomotion scores recorded weekly, a","[599, 193, 1093, 609]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +6,6,text,Urinary system disorders are serious complications of spinal cord injury that cause irreversible pathological changes in the bladder and greatly affect the quality of life of patients. Effective recov,"[600, 611, 1093, 1114]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +6,7,text,"Luxol fast blue (LFB), a copper-phthalocyanine dye, combines with myelin in an ethanol solution to enhance the staining of the myelin sheath.[20] The histological morphologies of the cavity area and m","[599, 1114, 1094, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +6,8,footer,"Adv. Mater. 2024, 36, 2310483","[93, 1487, 271, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +6,9,footer,2310483 (6 of 10),"[524, 1484, 658, 1507]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +6,10,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +6,11,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +7,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[97, 45, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,1,header,"ADVANCED MATERIALS +www.advmat.de","[934, 45, 1097, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,2,chart,,"[137, 156, 364, 331]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +7,3,chart,,"[369, 153, 616, 332]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +7,4,figure_title,C,"[139, 326, 159, 347]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,5,figure_title,d,"[625, 153, 644, 177]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,6,image,,"[147, 354, 239, 672]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,7,image,,"[242, 353, 335, 673]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,8,image,,"[341, 355, 439, 674]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,9,image,,"[440, 357, 533, 670]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,10,image,,"[536, 358, 628, 669]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,11,image,,"[629, 153, 1056, 671]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,12,figure_title,e,"[140, 678, 156, 697]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,13,image,,"[145, 687, 339, 928]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,14,image,,"[342, 690, 519, 928]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,15,image,,"[521, 683, 699, 927]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,16,image,,"[699, 682, 876, 928]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,17,image,,"[878, 681, 1055, 931]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +7,18,figure_title,f,"[139, 936, 152, 962]",figure_inner_text,0.9,"[""panel label / figure inner text: f""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,19,chart,,"[141, 941, 356, 1130]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +7,20,chart,,"[354, 939, 606, 1135]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +7,21,figure_title,h,"[595, 938, 612, 963]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,22,chart,,"[616, 935, 831, 1134]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +7,23,chart,,"[829, 938, 1039, 1133]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +7,24,figure_title,"Figure 4. BCH with wireless in situ ES promotes SCI animal functional recovery and neural regeneration. a) BBB scores of rats in each group, n = 6. b) Weights of bladders in different groups, n = 4. c","[96, 1147, 1096, 1302]",figure_caption,0.92,"[""figure_title label: Figure 4. BCH with wireless in situ ES promotes SCI animal f""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,25,text,analysis results are shown in Figure 4g. The LFB staining ratio of the total area significantly increased in the ES-treated group at week 8 post-injury compared to that in the BCH or SCI groups (P < 0,"[95, 1332, 587, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +7,26,text,"ES-treated groups. These results demonstrate that the BCH com- +bined with the intermediate ES dose could synergistically and ef- +fectively improve pathological function after SCI.","[606, 1332, 1097, 1398]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +7,27,text,"The myelin sheath, the membrane that surrounds the axon, can act as an insulator to prevent the transmission of electrical","[607, 1400, 1098, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +7,28,footer,"Adv. Mater. 2024, 36, 2310483","[99, 1487, 276, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +7,29,number,2310483 (7 of 10),"[530, 1484, 664, 1507]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +7,30,footer,© 2024 Wiley-VCH GmbH,"[937, 1487, 1096, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +7,31,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +8,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 45, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +8,1,header_image,,"[928, 44, 1091, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +8,2,figure_title,a,"[108, 160, 134, 188]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,3,figure_title,d,"[596, 154, 620, 186]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,4,image,,"[110, 160, 1072, 911]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +8,5,figure_title,b,"[113, 914, 137, 948]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,6,chart,,"[134, 918, 359, 1094]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +8,7,figure_title,C,"[340, 921, 363, 948]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,8,chart,,"[372, 922, 592, 1096]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +8,9,figure_title,e,"[586, 922, 610, 947]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +8,10,chart,,"[612, 915, 835, 1098]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +8,11,chart,,"[841, 918, 1062, 1095]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +8,12,figure_title,"Figure 5. BCH with wireless in situ ES promotes neural stem cell differentiation and BDNF/c-fos expression. a) Representative images showing Tuj1 (red, a neural biomarker of neuron-specific microtubul","[90, 1109, 1090, 1226]",figure_caption,0.92,"[""figure_title label: Figure 5. BCH with wireless in situ ES promotes neural stem ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,13,text,"impulses from one axon to another. Myelination at the site of a nerve injury provides a protective barrier against axonal regeneration. Myelin basic protein (MBP), a special biomarker of myelination d","[89, 1266, 582, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +8,14,text,"nerves (Figure 4e). As shown in Figure 4h,i, the mean percentage +of MBP/NF200+ staining in the BCH-M group was much higher +than that in the SCI, BCH, BCH-L, or BCH-H groups, and the +mean percentage of","[599, 1267, 1093, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +8,15,footer,"Adv. Mater. 2024, 36, 2310483","[93, 1487, 271, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,16,number,2310483 (8 of 10),"[524, 1484, 658, 1508]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +8,17,footer,© 2024 Wiley-VCH GmbH,"[931, 1487, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +8,18,aside_text,"15214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Conditio","[1155, 28, 1171, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +9,1,header_image,,"[934, 45, 1096, 116]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True +9,2,text,"medium dose had a strong influence on strengthening remyelination. As shown in Figure S12 (Supporting Information), classic myelin-wrapped nerve fiber structures were observed in the nerve regeneratio","[95, 149, 587, 347]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"To assess the differentiation of endogenous NSC differentiation at the injury sites eight weeks after surgery, IF co-staining of Tuj1 and GFAP was performed (Figure 5a). $ ^{[22]} $ Tuj1 is a neural b","[96, 346, 588, 1028]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,4,paragraph_title,3. Conclusions,"[98, 1054, 244, 1078]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Conclusions""]",section_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True +9,5,text,"In this study, we developed a WES strategy, in which a capacitive-coupling-responsive conductive hydrogel served simultaneously as a biodegradable regeneration scaffold and in situ wireless ES platfor","[96, 1092, 587, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +9,6,text,"fectively promote functional repair by enhancing remyelination, +accelerating axonal regeneration, facilitating the differentiation +of endogenous NSCs, and activating calcium downstream signal- +ing path","[606, 149, 1098, 283]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,paragraph_title,Supporting Information,"[608, 324, 840, 351]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supporting Information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True +9,8,text,Supporting Information is available from the Wiley Online Library or from the author.,"[607, 361, 1096, 401]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,paragraph_title,Acknowledgements,"[608, 443, 801, 469]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +9,10,text,"P.W., C.X., and X.Z. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (82202352, 82302405, 81771974, and 82271629).","[606, 481, 1097, 540]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,11,paragraph_title,Conflict of Interest,"[608, 582, 792, 608]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,False,True +9,12,text,The authors declare no conflict of interest.,"[608, 620, 894, 641]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +9,13,paragraph_title,Data Availability Statement,"[609, 684, 872, 708]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data Availability Statement""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +9,14,text,The data that support the findings of this study are available from the corresponding author upon reasonable request.,"[606, 721, 1097, 761]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,15,paragraph_title,Keywords,"[608, 803, 707, 830]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Keywords""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +9,16,text,"biodegradable hydrogels, conductive hydrogels, neural regeneration, tissue engineering, wireless electrical stimulation","[607, 840, 1097, 881]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,17,text,"Received: October 9, 2023 +Revised: December 28, 2023 +Published online: January 14, 2024","[865, 902, 1097, 961]",backmatter_body,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,True,True +9,18,reference_content,"[1] a) L. 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Wang, J.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +10,21,footer,"Adv. Mater. 2024, 36, 2310483","[94, 1488, 270, 1504]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +10,22,number,2310483 (10 of 10),"[521, 1485, 662, 1507]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +10,23,footer,© 2024 Wiley-VCH GmbH,"[932, 1488, 1089, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +10,24,aside_text,"5214095, 2024, 14, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202310483 by Shandong University Library, Wiley Online Library on [27/02/2026]. See the Terms and Condition","[1156, 35, 1171, 1538]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/DWQQK2YB/block_trace.csv b/tests/fixtures/ocr_real_papers/DWQQK2YB/block_trace.csv index e26352d7..b7451e39 100644 --- a/tests/fixtures/ocr_real_papers/DWQQK2YB/block_trace.csv +++ b/tests/fixtures/ocr_real_papers/DWQQK2YB/block_trace.csv @@ -107,11 +107,11 @@ Platform Utilizing Electromagnetic Fields","[74, 155, 1028, 268]",paper_title,0. 24,2,paragraph_title,4. Conclusion,"[76, 986, 247, 1016]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Conclusion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True 24,3,text,We developed a magnetoresponsive stem cell spheroid-based cartilage recovery platform that can precisely deliver stem cells using an EMA system and can stimulate these cells by LF-EMF to promote chond,"[75, 1050, 1033, 1411]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 25,0,header,Journal Pre-proof,"[504, 2, 830, 39]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p25 y=2/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False -25,1,text,fields can provide effective potential therapeutic agents to promote the regeneration of damaged tissue within articular cartilage.,"[75, 100, 1031, 186]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -25,2,paragraph_title,Conflict of Interest,"[76, 241, 311, 270]",backmatter_heading,0.8,"[""backmatter heading on page 25: Conflict of Interest""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,support_like,none,True,True -25,3,text,All other authors declare that they have no competing interests.,"[75, 359, 690, 387]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -25,4,paragraph_title,Acknowledgments,"[76, 444, 304, 474]",backmatter_heading,0.8,"[""backmatter heading on page 25: Acknowledgments""]",backmatter_heading_candidate,0.8,tail_nonref_hold_zone,heading_like,short_fragment,True,True -25,5,text,A. Yoo and G. Go contributed equally to this work. We thank Medical Microrobot Center of Chonnam National University for supporting the equipment. This research was supported by a grant of the Korea H,"[74, 518, 1032, 881]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +25,1,text,fields can provide effective potential therapeutic agents to promote the regeneration of damaged tissue within articular cartilage.,"[75, 100, 1031, 186]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,2,paragraph_title,Conflict of Interest,"[76, 241, 311, 270]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True +25,3,text,All other authors declare that they have no competing interests.,"[75, 359, 690, 387]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,4,paragraph_title,Acknowledgments,"[76, 444, 304, 474]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +25,5,text,A. Yoo and G. Go contributed equally to this work. We thank Medical Microrobot Center of Chonnam National University for supporting the equipment. This research was supported by a grant of the Korea H,"[74, 518, 1032, 881]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 26,0,header,Journal Pre-proof,"[503, 2, 831, 39]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p26 y=2/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False 26,1,paragraph_title,References,"[75, 102, 216, 133]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True 26,2,reference_content,"[1] C. Cooper, M.K. Javaid, N. Arden, Epidemiology of osteoarthritis, Atlas of osteoarthritis, Springer 2014, pp. 21-36.","[78, 166, 1027, 249]",reference_item,0.85,"[""reference content label: [1] C. Cooper, M.K. Javaid, N. Arden, Epidemiology of osteoa""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True diff --git a/tests/fixtures/ocr_real_papers/GTRPMM56/block_trace.csv b/tests/fixtures/ocr_real_papers/GTRPMM56/block_trace.csv new file mode 100644 index 00000000..6a5776e1 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/GTRPMM56/block_trace.csv @@ -0,0 +1,490 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,nature reviews rheumatology,"[75, 79, 425, 113]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,header,https://doi.org/10.1038/s41584-025-01236-7,"[782, 80, 1125, 105]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,header,Check for updates,"[957, 184, 1126, 211]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,text,Review article,"[75, 185, 216, 212]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True +1,4,doc_title,"Restoring articular cartilage: insights from structure, composition and development","[74, 236, 962, 451]",paper_title,0.8,"[""page-1 zone title_zone: Restoring articular cartilage: insights from structure, comp""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Alba Pueyo Moliner ☎ 1,2, Keita Ito 2,3, Frank Zaucke ☎ 4, Daniel J. Kelly 5, Mylène de Ruijter 1,2,6 & Jos Malda ☎ 1,2,6","[73, 507, 1011, 535]",authors,0.8,"[""page-1 zone author_zone: Alba Pueyo Moliner \u260e 1,2, Keita Ito 2,3, Frank Zaucke \u260e 4, D""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,paragraph_title,Abstract,"[75, 545, 167, 569]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True +1,7,abstract,Articular cartilage can withstand substantial compressive and shear forces within the joint and also reduces friction during motion. The exceptional mechanical properties of articular cartilage stem f,"[73, 610, 860, 1349]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,8,table,
Sections
Introduction
The anisotropic nature of articular cartilage
Collagen type II fibres in the articular cartilage matrix
• Articular cartilage is a highly anisotropic tissue that is characterized by depth-dependent collagen fibre orientation, which provides the tissue with its unique biomechanical propert","[73, 280, 590, 733]",structured_insert,0.85,"[""media label: table""]",media_asset,0.85,frontmatter_side_zone,support_like,none,False,False +2,3,text,• Insights gained from cartilage development and its anisotropic organization could inspire novel strategies for achieving long-term cartilage regeneration.,"[74, 739, 560, 806]",structured_insert,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,4,paragraph_title,Introduction,"[75, 845, 210, 868]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True +2,5,text,Articular cartilage is a highly specialized connective tissue located in the synovial joint cavities lining the end of the epiphyses. The tissue consists of a thin hyaline cartilage layer (-0.1–2.5 mm,"[73, 868, 593, 1106]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,The extracellular matrix (ECM) provides exceptional biomechanical support through its typical anisotropic structure and composition $ ^{5} $. Collagen type II is the main fibrillar protein in articula,"[73, 1106, 594, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,text,"cartilage that enables this tissue to withstand daily shear forces and +impact loading12.","[606, 223, 1124, 267]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,8,text,"The regenerative capacity of articular cartilage is limited owing to it being avascular, anearural and dependent on nutrient diffusion from the synovial fluid $ ^{13} $. Furthermore, although resident","[605, 267, 1126, 439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,9,text,"Collagen structure forms during late fetal and early juvenile development, with minimal turnover in the adult tissue $ ^{17} $. After articular cartilage injury, fibrotic scar tissue is deposited and ","[606, 439, 1127, 890]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +2,10,text,"In this Review, we explore the basic composition, structure and development of articular cartilage, with a particular focus on how the anisotropic composition and structure of the collagen and proteog","[605, 890, 1127, 1088]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,11,paragraph_title,The anisotropic nature of articular cartilage,"[607, 1103, 1054, 1126]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: The anisotropic nature of articular cartilage""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,12,text,"Articular cartilage is a highly anisotropic tissue; at birth, the ECM is homogenous and predominantly isotropic, but during maturation, the ECM composition and structure of non-calcified articular car","[605, 1126, 1127, 1236]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,paragraph_title,Collagen and proteoglycans in articular cartilage,"[607, 1255, 1018, 1277]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Collagen and proteoglycans in articular cartilage""]",subsection_heading,0.6,body_zone,body_like,none,True,True +2,14,text,"On the basis of the orientation of collagen fibres, the zones of articular cartilage can be classified into the superficial zone (also known as the tangential zone), the middle zone (also known as the","[605, 1277, 1127, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,header,Review article,"[77, 79, 308, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,image,,"[76, 219, 1122, 603]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +3,2,figure_title,"Fig. 1 | Development of knee articular cartilage from embryogenesis to adulthood. a, Interzone formation in the nascent limb occurs when flattened, condensed Gdf5⁺ (ref. 61) interzone cells emerge wit","[74, 617, 587, 781]",figure_caption,0.92,"[""figure_title label: Fig. 1 | Development of knee articular cartilage from embryo""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,3,figure_title,"self-renewing chondroprogenitors $ ^{26,56,67,94} $. d, After maturation, the tissue exhibits zonal organization: the superficial zone has collagen fibres oriented parallel to the surface, the middle ","[606, 617, 1125, 759]",figure_caption_candidate,0.85,"[""figure_title label: self-renewing chondroprogenitors $ ^{26,56,67,94} $. d, Afte""]",figure_caption,0.85,body_zone,legend_like,none,False,False +3,4,text,"with the maximum tensile stresses experienced by the joint surface during motion and weight bearing; high tensile strength occurs in a direction that aligns with these fibres $ ^{30} $. Consequently, ","[73, 847, 593, 1020]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,"The superficial zone is rich in lubricin (also known as proteoglycan-4), a proteoglycan that contributes to articular-surface lubrication (leading to static and kinetic friction coefficients of 0.01 a","[72, 1020, 594, 1299]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"In the middle zone, the orientation of collagen fibres is random, whereas in the deep zone – the thickest layer – fibres are aligned perpendicular to the surface (Fig. 1). Compared with other zones, t","[73, 1299, 593, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"This layered organization has remained preserved across the evolution +of terrestrial mammals27,48,49.","[606, 848, 1126, 890]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"The ECM is divided into three regions on the basis of chondrocyte proximity: the pericellular matrix (PCM, 2–4 µm), the territorial matrix and the interterritorial matrix. The PCM is in direct contact","[605, 891, 1128, 1237]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,The bottom-up development of articular cartilage,"[607, 1255, 1032, 1277]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: The bottom-up development of articular cartilage""]",subsection_heading,0.6,body_zone,body_like,none,True,True +3,10,text,"During embryonic development, articular cartilage formation begins with the establishment of the synovial joints $ ^{56} $. Lineage-tracing studies in mice have provided insights into this complex pro","[605, 1277, 1127, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,footer,Nature Reviews Rheumatology,"[76, 1523, 311, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,0,header,Review article,"[77, 80, 308, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,text,cartilage and other joint structures (such as the ligament and the meniscus). Several hypotheses have been proposed to explain how Gdf5-expressing cells give rise to tissue divergence $ ^{60} $. This ,"[73, 222, 594, 482]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,2,text,Chondroprogenitor cells that are present at the surface of the nascent joint contribute to the development of all the layers of articular cartilage and supply rapidly proliferating daughter cells that,"[72, 482, 594, 719]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"Some daughter cells will halt hypertrophy as they migrate downwards and retain a chondrocyte phenotype, forming a layer of non-ossified cartilage $ ^{67} $. The tidemark is the boundary between the no","[72, 719, 594, 958]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,Collagen type II fibres in the articular cartilage matrix,"[74, 973, 456, 1019]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Collagen type II fibres in the articular cartilage matrix""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +4,5,text,"Collagen is present in the articular ECM in the form of heterotypic fibres; typically, collagen type II is packed together with collagen type XI, creating tightly packed, resilient networks $ ^{6} $. ","[73, 1020, 593, 1301]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Collagen biosynthesis,"[74, 1319, 265, 1341]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Collagen biosynthesis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +4,7,text,Collagen type II biosynthesis begins with the transcription of the COL2A1 gene into two messenger RNA (mRNA) isoforms (IIA and IIB) by alternative splicing. Chondroprogenitor cells synthesize collagen,"[73, 1341, 593, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"Collagen IIB is synthesized by adult chondrocytes and is the major form +of collagen in adult articular cartilage73. Subsequent translation of the +IIB mRNA isoform results in the formation of the proco","[605, 223, 1127, 570]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,Fibrillogenesis and self-assembly,"[607, 589, 890, 611]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Fibrillogenesis and self-assembly""]",subsection_heading,0.6,body_zone,body_like,none,True,True +4,10,text,Fibrillogenesis is a step-by-step process that begins when chondrocytes release collagen molecules. These individual collagen molecules (~300 nm long and 1.5 nm in diameter) $ ^{77} $ fuse together la,"[606, 610, 1127, 1150]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,"Collagen fibre diameter increases with growth and cartilage depth $ ^{84} $ (Fig. 2c). Fibril synthesis is influenced by various mechanisms, including growth inhibition, degradation and interactions w","[605, 1149, 1127, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,header,Review article,"[77, 79, 308, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,image,,"[208, 226, 987, 1148]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +5,2,figure_title,"Fig. 2 | Collagen fibrillogenesis. a, Procollagen is released into the endoplasmic reticulum (ER). Procollagen α-chains have tripeptide glycine-X-Y (G-X-Y) repeats that are common to all collagens and","[74, 1159, 584, 1361]",figure_caption,0.92,"[""figure_title label: Fig. 2 | Collagen fibrillogenesis. a, Procollagen is release""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,3,figure_title,"collagen type XI (red) and fibril-associated collagens (such as collagen type IX (yellow))⁷⁰. b, The collagen fibril core is formed by two collagen type II and two collagen type XI microfibrils, which","[606, 1159, 1107, 1363]",figure_caption_candidate,0.85,"[""figure_title label: collagen type XI (red) and fibril-associated collagens (such""]",figure_caption,0.85,body_zone,legend_like,none,False,False +5,4,text,"Cartilage collagen is further interconnected by crosslinking, which is mostly facilitated by the enzyme lysyl-oxidase (LOX) $ ^{88} $. As cartilage matures, both the nature and number of crosslinks in","[74, 1405, 594, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,text,"with aging89. Initially, the collagen fibrils contain reducible crosslinks +(specifically, divalent ketoimines90), which gradually convert into +non-reducible crosslinks (specifically, trivalent pyridin","[606, 1405, 1127, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,0,header,Review article,"[76, 80, 308, 118]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,text,"is also essential for shaping the collagen network. Chondrocytes produce matrix metalloproteinases (MMPs) that specifically target and degrade collagen, destabilizing fibrils by targeting regions invo","[72, 223, 594, 570]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,2,paragraph_title,Postnatal collagen structure reorganization,"[73, 587, 523, 611]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Postnatal collagen structure reorganization""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +6,3,text,"Considering the composition, structure, postnatal development and poroelastic behaviour of articular cartilage, it is evident that collagen structure and architecture have a fundamental role in shapin","[73, 611, 594, 1195]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,paragraph_title,Collagen network formation in the deep zone,"[74, 1212, 454, 1234]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Collagen network formation in the deep zone""]",subsection_heading,0.6,body_zone,body_like,none,True,True +6,5,text,"For fibrous tissues, such as tendons, fibroblasts align with the principal stress direction, producing collagen type I fibres that extend into the matrix in the same orientation. This alignment occurs","[73, 1235, 594, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,text,"indirectly related to tissue growth during postnatal development. +Notably, collagen type II fibres are anchored to the subchondral bone69. +During postnatal development, chondrocyte progenitors give ri","[605, 223, 1127, 549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,paragraph_title,Collagen network formation in the superficial zone,"[606, 566, 1035, 589]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Collagen network formation in the superficial zone""]",subsection_heading,0.6,body_zone,body_like,none,True,True +6,8,text,"I tightly packed, tangentially oriented collagen fibres provide crucial support for shear resistance and normal mechanical function of the articular cartilage $ ^{102} $. In some species (mostly those","[604, 588, 1128, 1170]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"Overall, newly synthesized collagen fibrils are dispersed in the surrounding ECM. After collagen release, the loose fibrils are assembled in an isotropic manner into the existent network $ ^{72} $. Th","[604, 1169, 1128, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,footer,Nature Reviews Rheumatology,"[75, 1523, 311, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,doc_title,Review article,"[77, 79, 308, 116]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,1,image,,"[80, 220, 1117, 573]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,2,figure_title,"Fig. 3 | Proposed mechanism for the guidance of collagen type II fibres in articular cartilage. During postnatal development, bottom-up tissue growth is not driven by internal tissue remodelling but r","[74, 665, 576, 788]",figure_caption,0.92,"[""figure_title label: Fig. 3 | Proposed mechanism for the guidance of collagen typ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,3,vision_footnote,"Additionally, increasing mechanical load promotes the alignment of collagen fibres parallel to the surface in the superficial zone $ ^{115,119-122} $. The articular surface also grows and stretches du","[606, 665, 1111, 788]",footnote,0.7,"[""vision_footnote label: Additionally, increasing mechanical load promotes the alignm""]",footnote,0.7,body_zone,body_like,none,True,True +7,4,text,tangential strains that could potentially pull the collagen fibres parallel to its surface $ ^{100} $ (Fig. 3).,"[73, 847, 593, 891]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"Taken together, these observations point towards a biomechanically driven hypothesis of collagen realignment, in which the orientation of collagen fibres is influenced by the forces generated within t","[73, 891, 594, 1065]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,paragraph_title,Proteoglycans in the articular cartilage matrix,"[76, 1081, 545, 1105]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Proteoglycans in the articular cartilage matrix""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,7,text,"Alongside fibrillogenesis, self-assembly and postnatal reorganization of collagen type II, the collagen network interacts with various other ECM components, which determines the overall mechanical pro","[73, 1106, 594, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,text,"pressurization of the fluid retained by the GAGs mainly supports the +load10. In addition to generating swelling pressure, the collagen network +restricts proteoglycan movement, thereby resisting the ou","[605, 847, 1127, 1172]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,paragraph_title,Aggrecan biosynthesis and deposition,"[607, 1191, 932, 1213]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Aggrecan biosynthesis and deposition""]",subsection_heading,0.6,body_zone,body_like,none,True,True +7,10,text,"Aggrecan is composed of a core protein that is covalently bound to sulphated GAGs, mainly chondroitin sulphate and keratan sulphate. The core protein of the aggrecan monomer is transcribed from the AC","[605, 1213, 1128, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,0,header,Review article,"[77, 80, 308, 118]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,image,,"[212, 224, 989, 663]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +8,2,figure_title,"Fig. 4 | Proteoglycan aggrecan synthesis. The aggrecan core protein contains three globular domains (G1, G2 and G3) and a non-globular region between G2 and G3 for glycosaminoglycan (GAG) attachment. ","[74, 678, 583, 780]",figure_caption,0.92,"[""figure_title label: Fig. 4 | Proteoglycan aggrecan synthesis. The aggrecan core ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +8,3,figure_title,"to form the negatively charged GAGs keratan sulphate (KS) and chondroitin sulphate (CS) $ ^{134} $. Following glycosylation, aggrecan is secreted in vesicles into the extracellular matrix (ECM). In th","[604, 678, 1122, 781]",figure_caption_candidate,0.85,"[""figure_title label: to form the negatively charged GAGs keratan sulphate (KS) an""]",figure_caption,0.85,body_zone,legend_like,none,False,False +8,4,text,"is found in aggregates in the articular ECM; hence, the name of this proteoglycan. It binds non-covalently around a central hyaluronan filament through the N-terminal G1 domain. This interaction betwe","[73, 824, 594, 958]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,paragraph_title,Aggrecan structure and distribution,"[75, 976, 382, 998]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Aggrecan structure and distribution""]",subsection_heading,0.6,body_zone,body_like,none,True,True +8,6,text,"As previously mentioned, collagen fibres in the articular cartilage exhibit an anisotropic structure, and aggrecan has a depth-dependent gradient. At the surface, the proteoglycan content is relativel","[73, 999, 594, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,paragraph_title,Other proteoglycans and glycoproteins in cartilage,"[608, 825, 1035, 847]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Other proteoglycans and glycoproteins in cartilage""]",subsection_heading,0.6,body_zone,body_like,none,True,True +8,8,text,"The interaction between collagen type II and large proteoglycans, such as aggrecan, has a crucial role in tissue stiffness and resistance to deformation. This interaction is, in many cases, indirect a","[605, 845, 1128, 1107]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,paragraph_title,Attempts to restore cartilage mechanical function,"[607, 1125, 1122, 1147]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Attempts to restore cartilage mechanical function""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +8,10,text,"Attempts to restore carriage�h.ruction +Once skeletal maturity occurs, the collagen matrix cannot be further replaced $ ^{144} $. This lack of remodelling means that any damage to the arcade-like struc","[605, 1128, 1127, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,11,footer,Nature Reviews Rheumatology,"[76, 1523, 311, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,header,Review article,"[77, 79, 307, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,1,text,therefore an urgent need for more durable approaches to articular cartilage restoration.,"[73, 224, 592, 267]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,2,text,"Novel clinical approaches, such as cell-based therapies, which involve the use of stem cells or chondrocytes (including expanded chondrocytes) $ ^{149} $, are combined with soft hydrogel-based scaffol","[73, 267, 594, 676]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,All of these therapeutic strategies for the restoration of articular cartilage incorrectly assume that the collagen network in mature individuals retains the capacity for remodelling $ ^{25} $. Those ,"[73, 676, 594, 786]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"synthesis rate by mature chondrocytes is low. With the emergence +of rapid prototyping techniques, such as 3D bioprinting, the ability +to precisely deposit cell-containing hydrogels (also referred to a","[605, 224, 1127, 546]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,text,"To overcome this challenge, hydrogel-based bioprinting has been combined with other biofabrication approaches, such as melt-electrowriting (MEW) (Fig. 6) to generate articular cartilage implants with ","[605, 547, 1127, 786]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,image,,"[79, 824, 759, 1485]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +9,7,figure_title,"Fig. 5 | The main components of articular cartilage extracellular matrix. The extracellular matrix (ECM) of articular cartilage contains numerous components (only the main components are shown here, s","[775, 824, 1120, 1227]",figure_caption,0.92,"[""figure_title label: Fig. 5 | The main components of articular cartilage extracel""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +9,8,footer,Nature Reviews Rheumatology,"[75, 1523, 311, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,0,paragraph_title,Review article,"[77, 80, 308, 118]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False +10,1,figure_title,Table 1 | The function of articular cartilage proteoglycans and (glyco)proteins and their interactions with extracellular matrix (ECM) components,"[75, 221, 1067, 269]",table_caption,0.9,"[""table prefix matched: Table 1 | The function of articular cartilage proteoglycans ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +10,2,table,"
ProteinFunctionInteraction with ECM componentsRefs.
Proteoglycans
VersicanA large bottlebrush chondroit","[75, 275, 1123, 1491]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +10,3,footer,Nature Reviews Rheumatology,"[75, 1523, 311, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,paragraph_title,Review article,"[77, 80, 308, 115]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False +11,1,figure_title,Table 1 (continued) | The function of articular cartilage proteoglycans and (glyco)proteins and their interactions with extracellular matrix (ECM) components,"[78, 222, 1057, 268]",table_caption,0.9,"[""table prefix matched: Table 1 (continued) | The function of articular cartilage pr""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +11,2,table,"
ProteinFunctionInteraction with ECM componentsRefs.
Other (glyco)proteins (continued)
ElastinA protein ","[77, 279, 1123, 667]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +11,3,vision_footnote,"Indicates small leucine-rich proteoglycans. BMP, bone morphogenetic protein; COMP, cartilage oligomeric matrix protein; ECM, extracellular matrix; FGF, fibroblast growth factor; GAG, glycosaminoglycan","[74, 673, 1077, 705]",footnote,0.7,"[""vision_footnote label: Indicates small leucine-rich proteoglycans. BMP, bone morpho""]",footnote,0.7,body_zone,body_like,none,True,True +11,4,text,"cartilage and can remain stable in vivo, as demonstrated in horses, in which implants remained stable for 6 months $ ^{167} $. However, this approach is only temporary as PCL is biodegradable and so w","[73, 739, 594, 915]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,paragraph_title,Attempts to incorporate collagen architecture,"[74, 932, 550, 955]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Attempts to incorporate collagen architecture""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +11,6,text,"The anisotropic organization of the ECM, particularly the alignment of collagen fibres, is essential not only for the mechanical performance of cartilage tissue $ ^{173} $ but also for other tissues, ","[73, 955, 594, 1409]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,paragraph_title,Approaches to inducing collagen alignment,"[74, 1427, 443, 1449]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Approaches to inducing collagen alignment""]",subsection_heading,0.6,body_zone,body_like,none,True,True +11,8,text,"For collagen type I, alignment can be achieved with fluid flow-induced shear forces, which induce collagen monomer orientation along the flow direction $ ^{182-186} $. Alternatively, tension-based met","[73, 1449, 594, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"flow direction182–186. Alternatively, tension-based methods187,188 (such as +dip-pen nanolithography189, which relies on fibre stretching), can be +used to self-assemble the collagen monomers into netwo","[605, 737, 1128, 1343]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,text,"The application of these alignment techniques has not yet been explored for collagen type II fibres. In vivo, collagen type II fibres are thinner than collagen type I fibres, with less crystallinity a","[605, 1341, 1128, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,0,paragraph_title,Review article,"[77, 81, 307, 117]",noise,0.8,"[""running header: review article""]",noise,0.8,tail_nonref_hold_zone,heading_like,short_fragment,False,False +12,1,vision_footnote,a Traditional clinical approaches,"[79, 225, 313, 246]",footnote,0.7,"[""vision_footnote label: a Traditional clinical approaches""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +12,2,image,,"[113, 265, 306, 469]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +12,3,vision_footnote,Autograft or allograft transplantation,"[80, 476, 313, 494]",footnote,0.7,"[""vision_footnote label: Autograft or allograft transplantation""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +12,4,image,,"[336, 226, 538, 471]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +12,5,vision_footnote,Autologous chondrocyte transplantation,"[336, 477, 496, 510]",footnote,0.7,"[""vision_footnote label: Autologous chondrocyte transplantation""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +12,6,image,,"[575, 227, 770, 473]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +12,7,vision_footnote,Hydrogel-based therapies,"[576, 476, 742, 494]",footnote,0.7,"[""vision_footnote label: Hydrogel-based therapies""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +12,8,vision_footnote,b Biofabrication of biomechanically competent implants,"[79, 524, 473, 545]",footnote,0.7,"[""vision_footnote label: b Biofabrication of biomechanically competent implants""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +12,9,image,,"[79, 567, 563, 839]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +12,10,image,,"[571, 552, 768, 819]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +12,11,vision_footnote,C Novel approaches to long-term mechanical function restoration,"[82, 853, 535, 873]",footnote,0.7,"[""vision_footnote label: C Novel approaches to long-term mechanical function restorat""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True +12,12,image,,"[76, 892, 773, 1494]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +12,13,paragraph_title,Fig. 6 Strategies for guiding collagen in articular cartilage restoration and biofabrication.,"[791, 222, 1123, 262]",figure_caption_candidate,0.9,"[""figure caption candidate: Fig. 6 Strategies for guiding collagen in articular cartilag""]",figure_caption_candidate,0.9,tail_nonref_hold_zone,legend_like,figure_number,False,False +12,14,text,"a, Traditional approaches to articular cartilage restoration include autograft $ ^{10} $ or allograft $ ^{145} $ transplantation, autologous chondrocyte injection $ ^{20} $ and the incorporation of ch","[789, 259, 1120, 866]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +12,15,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1544]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +13,0,header,Review article,"[77, 79, 308, 116]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +13,1,text,"is governed by liquid crystallinity properties at high concentrations, and the critical concentration for fibre assembly and nucleation rate are considerably different from collagen type $ ^{201} $. M","[73, 222, 595, 440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,2,text,"Mechanical loading could serve as a potential stimulus for aligning collagen type II, as it does during postnatal development, in laboratory-grown articular-cartilage scaffolds $ ^{202} $. For instanc","[73, 437, 594, 1089]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +13,3,paragraph_title,Novel techniques for collagen guidance cartilage,"[75, 1105, 483, 1127]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Novel techniques for collagen guidance cartilage""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,False,True +13,4,text,Novel fabrication approaches have helped to advance the guidance of collagen type II networks in engineered cartilage implants. Fibrous organized scaffolds generated with MEW technology have been used,"[73, 1126, 594, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,5,paragraph_title,Glossary,"[609, 223, 700, 249]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Glossary""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +13,6,text,"Anisotropic +Having direction-dependent properties.","[607, 288, 856, 334]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,7,paragraph_title,Arcade-like structure,"[609, 352, 783, 375]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Arcade-like structure""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,8,text,"A collagen fibre arrangement in articular cartilage whereby fibres curve from the surface to the deep zone, anchoring to the subchondral bone.","[607, 375, 859, 463]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,9,text,"Beaded microfibrillar network +A structural arrangement of thin, +bead-like fibrils connected in a network.","[608, 479, 856, 549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,10,text,"Fibrillogenesis +The process of collagen fibril formation.","[608, 566, 856, 615]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,11,text,"Heterotypic fibres +Collagen fibres composed of more than one type of collagen molecule.","[608, 631, 858, 700]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,12,text,"Hypertrophy +The process by which cells undergo significant enlargement owing to volumetric increase and distinct metabolic and molecular changes.","[608, 724, 836, 829]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,13,text,"Isotropic +Having uniform properties in all +directions.","[609, 846, 807, 915]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,14,text,"Joint cavitation +The formation of the joint cavity during embryonic development, separating the joint into two articular surfaces.","[608, 933, 859, 1024]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,15,text,"Liquid crystallinity +A state of matter with properties between those of a liquid and a solid crystal, characterized by ordered molecular alignment.","[608, 1040, 840, 1152]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,16,paragraph_title,Molecular crowding,"[609, 1169, 776, 1193]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Molecular crowding""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,False,True +13,17,text,"A high concentration of macromolecules in a confined space that influences molecular interactions and assembly. +Nascent +Newly formed or immature.","[608, 1178, 860, 1258]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,18,text,"Nascent +Newly formed or immature.","[875, 288, 1048, 334]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,19,text,"Non-reducible crosslinks +A non-reversible chemical bond that permanently stabilizes collagen fibrils.","[874, 352, 1111, 420]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,20,paragraph_title,Nucleator,"[875, 438, 962, 460]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Nucleator""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True +13,21,text,A molecule or structure that promotes the initiation of fibrillogenesis.,"[875, 462, 1114, 506]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,22,paragraph_title,Procollagen,"[875, 523, 980, 547]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Procollagen""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True +13,23,text,The precursor molecule of collagen that undergoes enzymatic processing to form tropocollagen.,"[875, 548, 1112, 615]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,24,text,"Reducible crosslinks +A reversible chemical bond that +stabilizes collagen fibrils.","[875, 631, 1076, 700]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,25,text,"Resistance to the positive principal strain +The ability of a material to withstand tensile forces along the direction of the highest principal strain.","[875, 720, 1120, 829]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,26,text,"Split-line orientation pattern +A pattern observed on the surface of +cartilage that reflects the underlying +collagen fibre alignment.","[874, 846, 1108, 936]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,27,text,"Suprafibrillar assemblies +Higher-order structures formed by the +organization of fibrils into complex +networks.","[875, 953, 1113, 1043]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,28,paragraph_title,Tidemark,"[876, 1061, 957, 1085]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Tidemark""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True +13,29,text,Boundary between the calcified and non-calcified zones of articular cartilage.,"[875, 1085, 1095, 1151]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,30,paragraph_title,Tropocollagen,"[877, 1169, 999, 1192]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Tropocollagen""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True +13,31,text,The basic triple-helical collagen molecule that assembles into fibrils.,"[876, 1194, 1100, 1236]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,32,text,important proof that guiding collagen towards its native structure is feasible and could be combined with other additive manufacturing approaches to generate spatially organized osteochondral implants,"[607, 1298, 1126, 1364]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,33,text,"Besides MEW, the introduction of the filamented light (FLight) biofabrication technique $ ^{209} $ further highlights the ability to align collagen type II networks in chondral implants $ ^{210} $. FL","[606, 1363, 1127, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,34,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1544]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +14,0,header,Review article,"[77, 81, 307, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,1,text,"mechanical properties (Fig. 6). Similarly, aligned rod-shaped microgels have been explored to generate aligned ECM $ ^{211} $. By using microgels with magnetic properties, the angle of alignment could","[73, 223, 594, 505]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,2,paragraph_title,Challenges and considerations,"[74, 522, 397, 546]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Challenges and considerations""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +14,3,text,"This Review explores the basic biology of articular cartilage, from its cellular and ECM composition in adult tissue to postnatal development that gives rise to the complex tissue architecture. We emp","[73, 546, 594, 1041]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +14,4,text,Several knowledge gaps remain. Current literature focuses mainly on inducing chondrogenic differentiation for ECM production (both in cell and/or hydrogel-based therapies and in laboratory-grown impla,"[73, 1043, 594, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +14,5,text,"of bioactive stimuli that drive ECM organization, such as mechanical +loading, bottom–up tissue growth, collagen fibrillogenesis and fibre +crosslinking, could lead to the development of tissues with th","[605, 223, 1126, 331]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,"Although this Review focused mainly on structural aspects, it is also important to consider the inflammatory environment that is often present at sites of cartilage defect, especially in OA and trauma","[605, 332, 1127, 569]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,paragraph_title,Conclusion,"[608, 587, 733, 610]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +14,8,text,"As the field of tissue engineering advances, new approaches to chondral implants and collagen guidance will continue to emerge, enabling the development of more biomimetic constructs. By replicating t","[605, 610, 1128, 935]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,9,paragraph_title,Published online: 28 March 2025 References,"[608, 953, 844, 1006]",frontmatter_noise,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Published online: 28 March 2025 References""]",subsection_heading,0.6,body_zone,support_like,none,False,False +14,10,footer,,"[610, 988, 702, 1006]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False +14,11,reference_content,"1. Shepherd, D. E. T. & Seedhom, B. B. Thickness of human articular cartilage in joints of the lower limb. Ann. Rheum. Dis. 58, 27–34 (1999).","[609, 1007, 1121, 1039]",reference_item,0.85,"[""reference content label: 1. Shepherd, D. E. T. & Seedhom, B. B. Thickness of human ar""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +14,12,reference_content,"2. 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Significance of type II ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +18,34,paragraph_title,Acknowledgements,"[609, 589, 766, 607]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True +18,35,text,"A.P.M., M.d.R., K.I. and J.M. would like to acknowledge the support of the Dutch Research Council (NWO), project LS-NeoCarE (NWA1389.20.192) and the Gravitation Program ""Materials Driven Regeneration""","[607, 608, 1125, 769]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,36,paragraph_title,Author contributions,"[609, 782, 772, 799]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True +18,37,text,"A.P.M. researched data for the article. A.P.M., J.M. and M.d.R. wrote the article. All authors contributed substantially to discussion of the content and reviewed and/or edited the manuscript before s","[608, 800, 1097, 849]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,38,paragraph_title,Competing interests,"[610, 863, 769, 880]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing interests""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,False,True +18,39,text,The authors declare no competing interests.,"[610, 882, 854, 896]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,40,paragraph_title,Additional information,"[610, 910, 785, 927]",backmatter_heading,0.5,"[""backmatter boundary candidate: Additional information""]",backmatter_boundary_candidate,0.5,,unknown_like,none,True,True +18,41,text,Supplementary information The online version contains supplementary material available at https://doi.org/10.1038/s41584-025-01236-7.,"[608, 928, 1119, 960]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,42,text,"Peer review information Nature Reviews Rheumatology thanks Daniel Grande and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.","[608, 976, 1112, 1010]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,43,text,Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[608, 1024, 1084, 1057]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True +18,44,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[608, 1071, 1103, 1137]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,45,text,© Springer Nature Limited 2025,"[610, 1151, 788, 1169]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +18,46,footnote,"Regenerative Medicine Center Utrecht, Utrecht, the Netherlands. $ ^{2} $Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands. $ ^{3} $Department of Biomedical Engin","[76, 1235, 1111, 1343]",footnote,0.7,"[""footnote label: Regenerative Medicine Center Utrecht, Utrecht, the Netherlan""]",footnote,0.7,,unknown_like,none,True,True +18,47,footer,Nature Reviews Rheumatology,"[76, 1523, 310, 1544]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/K7R8PEKW/block_trace.csv b/tests/fixtures/ocr_real_papers/K7R8PEKW/block_trace.csv new file mode 100644 index 00000000..7bc68305 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/K7R8PEKW/block_trace.csv @@ -0,0 +1,588 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,REVIEW,"[98, 53, 210, 81]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header_image,,"[1037, 1, 1190, 27]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,2,header,ADVANCED HEALTHCARE MATERIALS,"[973, 41, 1096, 97]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,3,header,www.advhealthmat.de,"[925, 97, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,4,doc_title,Extracellular Matrix-Surrogate Advanced Functional Composite Biomaterials for Tissue Repair and Regeneration,"[97, 148, 1088, 238]",paper_title,0.8,"[""page-1 zone title_zone: Extracellular Matrix-Surrogate Advanced Functional Composite""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,5,text,"Milad Vahidi, Amin S. Rizkalla, and Kibret Mequanint $ ^{*} $","[96, 269, 715, 301]",authors,0.8,"[""page-1 zone author_zone: Milad Vahidi, Amin S. Rizkalla, and Kibret Mequanint $ ^{*} ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,abstract,"Native tissues, comprising multiple cell types and extracellular matrix components, are inherently composites. Mimicking the intricate structure, functionality, and dynamic properties of native compos","[97, 363, 735, 940]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,7,footnote,"M. Vahidi, A. S. Rizkalla, K. Mequanint +Department of Chemical and Biochemical Engineering +The University of Western Ontario +London N6A5B9, Canada +E-mail: kmequani@uwo.ca +A. S. Rizkalla, K. Mequanint +","[96, 1061, 467, 1230]",footnote,0.7,"[""footnote label: M. Vahidi, A. S. Rizkalla, K. Mequanint\nDepartment of Chemic""]",footnote,0.7,body_zone,body_like,none,True,True +1,8,paragraph_title,1. Introduction,"[766, 351, 914, 375]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,9,text,"Biomaterials, encompassing a wide range of metals, ceramics, polymers, and their hybrids, are engineered to interact with biological systems for medical purposes. Whether intended for temporary or per","[764, 389, 1100, 1026]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,10,footnote,The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adhm.202401218,"[100, 1260, 587, 1300]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: The ORCID identification number(s) for the author(s) of this""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,11,text,"although similar in composition, exhibit distinct porosity and mechanical responses, with cortical bone showing linear elasticity due to its homogeneity and anisotropy, whereas cancellous bone display","[605, 1027, 1098, 1136]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,12,footnote,"© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, whic","[95, 1303, 585, 1412]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2024 The Author(s). Advanced Healthcare Materials publishe""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,13,text,"Similarly, articular cartilage showcases a complex organization of collagen fibrils and glycosaminoglycans (GAGs), with GAGs providing compression resistance through their osmotic interaction with wat","[605, 1136, 1099, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,14,footer,DOI: 10.1002/adhm.202401218,"[97, 1420, 340, 1442]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,15,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98, 1487, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,16,footer,2401218 (1 of 20),"[397, 1484, 531, 1507]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,reference_like,reference_numeric_dot,False,False +1,17,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1487, 1098, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[91, 46, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,1,header,ADVANCED HEALTHCARE MATERIALS advhealthmat.de,"[965, 40, 1091, 116]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,figure_title,a,"[104, 157, 129, 176]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +2,3,image,,"[101, 155, 401, 349]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,4,chart,,"[448, 154, 699, 360]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,5,chart,,"[102, 379, 399, 646]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,6,chart,,"[415, 375, 695, 642]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,7,chart,,"[709, 158, 1079, 634]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,8,chart,,"[118, 662, 395, 929]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,9,chart,,"[415, 663, 691, 933]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,10,chart,,"[715, 638, 1063, 936]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,11,figure_title,Figure 1. Anisotropic characteristics of natural tissues: a) the wave-like arrangement of collagen fibers within a rabbit's thoracic aorta subjected to 80 mmHg pressure. $ ^{[12]} $ b) quasistatic and,"[89, 950, 1095, 1276]",figure_caption,0.92,"[""figure_title label: Figure 1. Anisotropic characteristics of natural tissues: a)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,12,text,"and mechanical attributes of the aforementioned human tissues requires a combination of materials, as a single material alone cannot meet all these complex requirements. Thus, composite biomaterials p","[89, 1310, 582, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,13,text,"mer/bioactive filler composites, polymer/polymer filler compos- +ites, polymer/metal filler composites, and bioactive glass/carbon +filler composites. Each category provides unique benefits, aiding +in achiev","[599, 1310, 1093, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,14,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93, 1487, 336, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,15,footer,2401218 (2 of 20),"[391, 1484, 525, 1507]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False +2,16,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[581, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,17,aside_text,"2022659, 2024, 27, Downloaded from https://advancedonlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditions","[1155, 30, 1172, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,frontmatter_side_zone,support_like,none,False,False +3,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[967, 40, 1096, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,image,,"[99, 141, 1092, 653]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,figure_title,Figure 2. A rationale for nature-inspired tissue-mimicking biomaterial design strategy.,"[96, 669, 673, 691]",figure_caption,0.92,"[""figure_title label: Figure 2. A rationale for nature-inspired tissue-mimicking b""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,4,text,"and durability, coupled with the flexibility of polymers. $ ^{[1]} $ On the other hand, polymer-carbon nanomaterial composites leverage the unique electrical and thermal properties of carbon nanomater","[95, 717, 587, 960]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,This review provides a comprehensive discussion of the advancements across the entire spectrum of composite biomaterials used as functional systems to restore or regenerate tissues. Our aim is to offe,"[95, 960, 587, 1161]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,paragraph_title,2. Native Tissue-mimicking Composite Biomaterials,"[96, 1183, 471, 1232]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Native Tissue-mimicking Composite Biomaterials""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +3,7,text,The quest to emulate the intricate composite nature of biological tissues in regenerative medicine pivots on developing functional composite biomaterials. These biomaterials stand out due to their non,"[95, 1245, 587, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"we aim to create materials that replicate the complex microarchi- +tecture of biological systems, which is pivotal for the engineering +of effective tissue constructs.[14–16]","[605, 718, 1097, 784]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,Composite biomaterials are particularly significant in this context because they inherently possess the capability to imitate the composite structure of tissues. These materials offer a dual advantage,"[604, 785, 1098, 1268]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"In their versatility, composite biomaterials excel at adapting to the varying mechanical attributes among different tissues and within the same tissue type. When scrutinized against single-material co","[604, 1267, 1098, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98, 1487, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,12,footer,2401218 (3 of 20),"[396, 1484, 531, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +3,13,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,14,aside_text,"2022659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Condition","[1155, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +4,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[967, 39, 1090, 112]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,2,header,www.advhealthmat.de,"[919, 97, 1091, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,text,"responses to composite biomaterials also tend to be more favorable, as they usually foster more positive cellular activities such as adhesion, proliferation, and differentiation and present a reduced ","[90, 149, 581, 237]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,text,"From the engineering standpoint, designing and manufacturing composite biomaterials involves complex processes that may be more costly. Nevertheless, the outstanding performance and the ability for pr","[90, 237, 582, 436]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,paragraph_title,3. Composite biomaterials for bone repair and regeneration,"[91, 459, 534, 511]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Composite biomaterials for bone repair and regeneration""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +4,6,paragraph_title,3.1. The materials nexus,"[91, 521, 281, 544]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. The materials nexus""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,7,text,"As a vascularized composite tissue, bone is subjected to considerable stress, necessitating biomaterials that possess suitable mechanical strength and durability, biocompatibility, and in certain case","[89, 566, 582, 1093]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"The mechanical strength, rigidity, and bonding of composite biomaterial to the native bone must be sufficient to support and transmit the force that promotes regeneration. In vivo, the angiogenic pote","[89, 1092, 582, 1355]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,text,Hydroxyapatite $ [Ca_{10}(PO_{4})_{6}(OH)_{2}] $ is the primary inorganic constituent in human teeth and bones and is highly bioactive and biocompatible. HA has been steadily incorporated into biomat,"[90, 1356, 582, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,10,text,"been coated onto prosthetic metal implants to promote bone +integration.[32] Accordingly, it has been found that the use of +iron-reinforced hydroxyapatite nanorods, combined with colla- +gen/polycaprola","[598, 148, 1093, 741]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,text,Mg/poly(Lactic acid) (PLA) composites can potentially replace traditional non-degradable metallic implants for long-bone fractures. Evidence has emerged indicating the remarkable tensile and flexural ,"[598, 741, 1093, 1355]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,"The ease of surgical positioning and robust graft fixation in critical long bone defects is also a recognized challenge, particularly when using conventional hard bone allografts or brittle synthetic ","[599, 1354, 1092, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93, 1487, 336, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,14,footer,2401218 (4 of 20),"[391, 1484, 525, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +4,15,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[580, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +4,16,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +5,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[97, 45, 345, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[972, 40, 1096, 114]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,2,header,www.advhealthmat.de,"[925, 98, 1097, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,3,image,,"[103, 154, 404, 209]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,4,chart,,"[105, 213, 406, 516]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,5,figure_title,d,"[432, 175, 449, 196]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,6,image,,"[434, 174, 761, 300]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,7,image,,"[761, 160, 1087, 297]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,chart,,"[105, 522, 395, 652]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,9,image,,"[418, 304, 745, 484]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,10,image,,"[745, 308, 1076, 485]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,11,image,,"[415, 492, 729, 655]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,12,image,,"[738, 508, 1084, 636]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,13,chart,,"[104, 665, 377, 840]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,chart,,"[376, 667, 549, 843]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,15,image,,"[548, 661, 1087, 774]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,16,chart,,"[116, 839, 367, 1024]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,17,figure_title,Picture,"[559, 806, 575, 851]",figure_caption_candidate,0.85,"[""figure_title label: Picture""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +5,18,image,,"[560, 774, 705, 895]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,19,chart,,"[367, 848, 570, 1020]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,20,figure_title,Masson,"[560, 938, 572, 988]",figure_caption_candidate,0.85,"[""figure_title label: Masson""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +5,21,image,,"[707, 775, 830, 895]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,22,image,,"[574, 896, 705, 1022]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,23,image,,"[833, 775, 957, 896]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,24,image,,"[706, 899, 832, 1021]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,25,image,,"[832, 898, 961, 1022]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,26,image,,"[961, 777, 1089, 1021]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,27,figure_title,Figure 3. a) A sequence of images illustrating the process of compressing and then allowing a 3D-printed HA-PLGA cylinder of 1 cm diameter to regain its shape over one compression cycle.[23] b) Long-t,"[95, 1035, 1101, 1415]",figure_caption,0.92,"[""figure_title label: Figure 3. a) A sequence of images illustrating the process o""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,28,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[99, 1488, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,29,number,2401218 (5 of 20),"[396, 1485, 531, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +5,30,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1488, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,31,aside_text,"21922659, 2024, 27. Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 32, 1171, 1536]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +6,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,1,header,ADVANCED HEALTHCARE MATERIALS,"[968, 40, 1090, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +6,2,header,www.advhealthmat.de,"[919, 97, 1091, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,3,text,"tricalcium phosphate, $ [40,41] $ or bioactive glass. $ [20,42] $ While softer alternatives like polymer meshes, hydrogels, $ [43] $ and collagen sponges $ [44] $ or foams exist, they often lack the n","[89, 148, 582, 589]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,text,Composite biomaterials designed for non-load-bearing bone defects frequently found in cranial bones and smaller bones require a different approach. The lower mechanical stress experienced by these bon,"[89, 587, 582, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,text,"approximately 200 μm/day,[54] this slow pace can result in oxy- +gen and nutrient deficiencies in large bone defects, increasing +the risk of graft failure. Soft substrates, such as fibrin gel, pro- +mote ","[599, 149, 1092, 477]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,text,"Conversely, cell-free scaffolds depend on tissue-resident cell migration, which is less effective and slower. Thus, while both scaffold types improve oxygen and nutrient delivery, cell-loaded fibrin g","[600, 478, 1092, 631]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,Research revealed that the development of composite hydrogels containing GelMA and Li-modified bioglass (GM/M-Li) served as a significant advancement in treating diabetic bone defects. These hydrogels,"[599, 631, 1093, 1029]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,paragraph_title,3.2. The signaling nexus,"[602, 1071, 790, 1094]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. The signaling nexus""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,9,text,"In tissue engineering, bioactivity entails the intentional and regulated interaction between the material and the tissues. This interplay can result in varied outcomes such as fostering cell adhesion,","[600, 1113, 1092, 1334]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"Composite biomaterials could potentially be designed to interact with the various signaling pathways implicated in bone metabolism, thereby allowing for more effective control over tissue formation. I","[599, 1333, 1093, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93, 1487, 336, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,12,footer,2401218 (6 of 20),"[391, 1484, 525, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +6,13,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[581, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +6,14,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +7,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[973, 40, 1096, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,2,header,www.advhealthmat.de,"[926, 98, 1097, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,3,figure_title,"Table 1. Clinical needs, applications, and exemplary recent advances in bone tissue engineering.","[97, 149, 736, 171]",table_caption,0.9,"[""table prefix matched: Table 1. Clinical needs, applications, and exemplary recent ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +7,4,table,
Clinical needPractical applicationRecent advancesReferences
Mechanical Strength and DurabilityComposite biomaterials combining hydro,"[96, 185, 1094, 478]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +7,5,text,"main mechanisms.[56] First, metal ions, especially calcium, influence signaling pathways that balance osteoblast and osteoclast activity and govern stem cell differentiation. Second, material topograp","[95, 520, 588, 1377]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Not surprisingly, addressing the multifaceted clinical needs is essential for developing effective and reliable treatments for bone tissue repair. Different clinical scenarios require biomaterials wit","[95, 1377, 588, 1444]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,text,"als with specific properties to ensure optimal bone repair and re- +generation. Mechanical strength and durability are necessary for +load-bearing bone defects caused by trauma or osteoporotic frac- +ture","[604, 520, 1099, 963]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,paragraph_title,4. Composite biomaterials for articular cartilage repair,"[606, 985, 1065, 1037]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Composite biomaterials for articular cartilage repair""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +7,9,text,"Osteoarthritis (OA) is a chronic condition impacting millions worldwide, making it a leading cause of disability. The pathogenesis, although still not entirely understood, can be traced to a variety o","[604, 1048, 1099, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98, 1487, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,11,footer,2401218 (7 of 20),"[396, 1484, 531, 1508]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +7,12,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,13,aside_text,"21922659, 2024, 27. Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +8,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,1,header,ADVANCED HEALTHCARE MATERIALS,"[968, 40, 1090, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +8,2,header,www.advhealthmat.de,"[919, 97, 1091, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,3,text,"the potential of biodegradable alternatives. Essentially, piezoelectric materials convert mechanical stress into electrical energy and vice versa. Classic piezoelectric materials include lead zirconat","[89, 149, 582, 567]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"Biodegradable piezoelectric nanofibers like PLLA, used in conjunction with physical activity, have demonstrated potential in cartilage regeneration. $ ^{[66]} $ The in-vivo results indicated that piez","[89, 565, 582, 1334]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"Innovatively, injectable hydrogels have drawn much attention in cartilage regeneration. The novel design of nanofiber composite microchannel-containing hydrogels inspired by the tunnel-piled structure","[89, 1332, 582, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"tosan (APA/CMCS) hydrogels, thermosensitive gelatin mi- +crorods (GMs) act as a pore-forming agent, and coaxial +electrospinning polylactic acid/gelatin fibers (PGFs) loaded +with kartogenin (KGN) functio","[599, 150, 1093, 544]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,text,"Continuing with the theme of regenerative strategies, the use of viscoelastic hydrogels for chondrocyte culture and the creation of self-healing materials have come into focus. The former promotes a n","[598, 544, 1093, 1026]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"Administering therapeutics via intra-articular injection proves to be an effective method for treating OA. Accordingly, an injectable hydrogel integrated with liposome-anchored teriparatide is another","[598, 1027, 1093, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93, 1487, 336, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,10,footer,2401218 (8 of 20),"[391, 1483, 526, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +8,11,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[580, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +8,12,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +9,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,ADVANCED HEALTHCARE MATERIALS,"[974, 40, 1095, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +9,2,header,www.advhealthmat.de,"[925, 97, 1097, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,3,text,"capacity to self-renew hydration layers, thereby minimizing friction and maintaining cellular balance. Their smooth rolling mechanism ensures ongoing exposure of liposomes on their surface, continuous","[95, 149, 589, 874]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,The aging population's increasing pain and disability underscore the need for understanding signaling mechanisms such as nuclear factor $ \kappa $B (NF- $ \kappa $B) identified as the transcription f,"[95, 874, 589, 1423]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,paragraph_title,5. Composite biomaterials for cardiac tissue repair,"[606, 149, 1094, 176]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Composite biomaterials for cardiac tissue repair""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +9,6,text,"The heart muscle is both elastic and strong, capable of constant rhythmic contractions throughout life. To mimic these properties, soft biomaterials such as hydrogels are often reinforced with elastom","[604, 188, 1099, 1418]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98, 1487, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,8,footer,2401218 (9 of 20),"[396, 1483, 531, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +9,9,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,10,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1154, 29, 1172, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +10,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,1,header,ADVANCED HEALTHCARE MATERIALS,"[969, 39, 1090, 97]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,none,False,False +10,2,header,www.advhealthmat.de,"[919, 97, 1091, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,3,text,pathogenesis of early myocardial infarction by addressing the critical issue of mitochondrial dysfunction in cardiomyocytes. $ ^{[93]} $,"[88, 149, 581, 193]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,text,A stretchable and anisotropic conductive composite hydrogel could be prepared from polyacrylamide/polypyrrole composites.[94] This stretch-induced strategy to make polypyrrole nanotubes aligned within,"[89, 190, 583, 1050]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,5,text,"In addition to cardiac tissue repair, composite biomaterials have also been used as cardiac monitoring devices. Thus, wearable ultrasonic devices and soft, stretchable elastomers are emerging as promi","[89, 1048, 582, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"the dynamic examination of the left ventricle, promoting compre- +hensive cardiac monitoring.[102] Additionally, the quest for con- +ductive, stretchable, and biocompatible materials for wearable +and im","[598, 149, 1092, 521]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,text,"While considerable progress has been made in cardiac tissue engineering using composite biomaterials, creating functional cardiac tissue with controlled cell orientation, mechanical anisotropy, and hi","[599, 522, 1093, 764]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,paragraph_title,6. Other functional composite biomaterials for tissue mimicry,"[601, 787, 1049, 839]",section_heading,0.85,"[""paragraph_title label with numbering: 6. Other functional composite biomaterials for tissue mimicr""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +10,9,paragraph_title,6.1. Conductive composite 3D scaffolds,"[601, 850, 904, 873]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.1. Conductive composite 3D scaffolds""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,10,text,"The primary problem of excitable tissues (e.g., cardiac and nerve tissues) is to build the electrical microenvironment to perform biomimetic electrical signal transmission.[105] Conductive hydrogels a","[599, 894, 1094, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,11,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[92, 1487, 337, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,12,footer,2401218 (10 of 20),"[386, 1484, 529, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +10,13,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[580, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +10,14,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1154, 29, 1172, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +11,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 45, 346, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[972, 40, 1096, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,2,header,www.advhealthmat.de,"[925, 98, 1097, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,3,chart,,"[106, 159, 403, 448]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,4,chart,,"[419, 160, 727, 381]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,5,figure_title,d,"[763, 160, 784, 184]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +11,6,chart,,"[766, 160, 1086, 382]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,7,chart,,"[106, 463, 408, 769]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,8,image,,"[424, 392, 831, 560]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,9,chart,,"[853, 387, 1086, 571]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,10,image,,"[438, 568, 633, 737]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,11,image,,"[641, 569, 831, 737]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,12,chart,,"[859, 580, 1088, 762]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,13,image,,"[105, 777, 846, 1094]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,14,chart,,"[850, 783, 1089, 935]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,15,chart,,"[853, 943, 1086, 1093]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +11,16,figure_title,Figure 4. Conductive composite scaffolds for neural and cardiac tissue functional recovery. Top-left box: Neuromodulation in the peripheral nervous system using SG₂ (poly(sulfobetaine vinylimidazolium,"[95, 1105, 1099, 1413]",figure_caption,0.92,"[""figure_title label: Figure 4. Conductive composite scaffolds for neural and card""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,17,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[99, 1487, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,18,number,2401218 (11 of 20),"[392, 1484, 535, 1507]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +11,19,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,20,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1154, 29, 1172, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +12,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[966, 39, 1091, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,2,header,www.advhealthmat.de,"[919, 97, 1091, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,3,text,"host tissues, making the hydrogels biomimetic. Furthermore, by selecting suitable polymeric components and adjusting moisture content, the mechanical characteristics of hydrogels, such as modulus, may","[89, 149, 581, 303]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,There are several fabrication strategies for conductive hydrogels for tissue engineering and regenerative medicine. The versatility of hydrogel fabrication which is attributed to the diverse gelation ,"[89, 302, 582, 850]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"Native tissues are responsive to a variety of mechanical stimuli, such as stretching, compression, and shear forces. To retain structural integrity and usefulness, hydrogels utilized in tissue enginee","[90, 851, 582, 1314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,text,"pGO-PAM hydrogel, composed of Polydopamine (PDA), partially +reduced Graphene Oxide (pGO), and Polyacrylamide (PAM), +was successfully synthesized through a three-step process.[154] +Dopamine was initial","[598, 148, 1093, 675]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,text,"Although hydrogels offer enormous promise for biomedical applications, their implantable uses are constrained since hydrogels eventually swell under physiological conditions, resulting in considerable","[599, 675, 1093, 1026]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,8,text,"The rationale behind design strategies for electroconductive porous composite scaffolds is to create a biomaterial that can mimic the electrical properties of native tissues and support cell growth, d","[598, 1025, 1093, 1314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,footnote,compression (right).[95] i) Transplantation of the composite onto a pig's heart.[95] j) Immunostaining of cardiac-specific proteins (α-actinin and CX-43) in RCMs cultured in various scaffolds for 7 da,"[89, 1363, 1095, 1443]",footnote,0.7,"[""footnote label: compression (right).[95] i) Transplantation of the composite""]",footnote,0.7,body_zone,body_like,none,True,True +12,10,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93, 1487, 337, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,11,footer,2401218 (12 of 20),"[386, 1484, 530, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +12,12,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[580, 1487, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,13,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adim.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 22, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +13,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[973, 40, 1095, 113]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,2,header,www.advhealthmat.de,"[926, 98, 1097, 116]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,3,text,"It is acknowledged that porous scaffolds featuring interconnected pores can stimulate cell infiltration, facilitate nutrient exchange, and promote tissue regeneration. The porosity of the scaffold can","[95, 148, 588, 811]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,paragraph_title,6.2. Conductive composite 2D films,"[96, 851, 368, 872]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.2. Conductive composite 2D films""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +13,5,text,"Conductive composite films are made of conductive particles embedded in a polymer matrix. These films have potential applications in various fields, such as electronic devices, sensors, energy storage","[95, 895, 588, 1423]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,6,text,"ity and superior tensile modulus compared to pure silk fibroin +matrices.[164]","[605, 149, 1097, 192]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,text,"Composite films made of graphene oxide (GO) and either polypyrrole (PPy-GO) or PEDOT-GO were examined for their cytocompatibility with cardiomyocytes and neural progenitors. $ ^{[165]} $ However, usin","[604, 193, 1098, 654]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,8,text,"Adding ceramic to polymers can have both positive and negative effects on their properties, but few studies have directly compared the effects of different types of inorganic additives. A comparison o","[605, 654, 1098, 1048]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,9,text,"Conductive polymers and organic/inorganic composites may be molded into various shapes and forms, and because they are flexible, they can also be utilized as wearable bioelectronic materials. Nanopart","[604, 1048, 1099, 1424]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,10,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98, 1487, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,11,footer,2401218 (13 of 20),"[392, 1484, 536, 1507]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False +13,12,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,13,aside_text,"21922659, 2024, 27. Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 30, 1171, 1534]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,body_zone,body_like,none,False,False +14,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +14,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[967, 39, 1091, 114]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +14,2,header,www.advhealthmat.de,"[919, 97, 1091, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +14,3,text,"been investigated.[168] To address the issue of IR- and thermal radiation-shielding function distortion when the shielding fiber is exposed to atmospheric water, the surface of the PU-ATO composite fi","[89, 148, 582, 369]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +14,4,text,"The functioning of various organs and systems is dependent on the nervous system; thus, there is a need for new techniques in designing neural stimulation to restore function following injury. A condu","[89, 368, 582, 810]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +14,5,paragraph_title,6.3. Magnetic and composite biomaterials,"[90, 850, 411, 873]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.3. Magnetic and composite biomaterials""]",subsection_heading,0.85,,unknown_like,heading_numbered,True,True +14,6,text,Magnetic nanoparticles (MNPs) are one of the most significant categories of nanomaterials studied for potential use in nanomedicine. Using MNPs allows the creation of soft composite biomaterials for v,"[90, 894, 582, 1246]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +14,7,text,"As an alternative to electric fields and acoustic waves, cardiac tissue engineering can incorporate magnetic hydrogel components to mimic the physical and biological organization of cardiac tissues an","[89, 1246, 583, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +14,8,text,"sis and improve cardiac function in infarcted cardiac tissue.[178] +The magnetic nanoparticles consisted of a Fe3O4 core and a sil- +ica shell, decorated with poly (ethylene glycol) and two types of +ant","[598, 147, 1094, 741]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +14,9,text,"Neural tissue, which is responsible for the transmission of nerve impulses within the nervous system, primarily consists of neurons possessing a cell body, axons, and dendrites. Unlike anisotropic tis","[598, 740, 1093, 1270]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +14,10,paragraph_title,7. Composite biomaterials for therapeutic drug delivery,"[600, 1292, 1053, 1344]",unknown_structural,0.85,"[""paragraph_title label with numbering: 7. Composite biomaterials for therapeutic drug delivery""]",section_heading,0.85,reference_zone,reference_like,reference_numeric_dot,False,True +14,11,text,"Composite biomaterials possess key features, including tunability, improved performance (mechanical properties, biocompatibility, and controlled release profile), and versatility that make them good c","[599, 1354, 1094, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +14,12,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[92, 1487, 337, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +14,13,footer,2401218 (14 of 20),"[385, 1483, 529, 1507]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +14,14,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[580, 1486, 1091, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +14,15,aside_text,"21922659, 2024, 27. Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202401218 by Shandong University Library, Wiley Online Library on [05(02/2026)]. See the Terms and Conditi","[1155, 30, 1171, 1540]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +15,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[98, 46, 345, 117]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +15,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[973, 39, 1096, 115]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +15,2,header,www.advhealthmat.de,"[925, 98, 1097, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +15,3,text,composite biomaterials in drug delivery and tissue engineering is becoming increasingly frequent owing to their superior performance. $ ^{[182]} $ When designing composite biomaterials for drug delive,"[95, 149, 588, 391]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +15,4,text,"To enhance the bioactivity of the drug, several factors need to be considered, including the use of protective carriers, drug loading, and release modifications, incorporation of bioactive materials s","[95, 391, 589, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +15,5,text,"efficiency for tissue engineering and other biomedical applica- +tions. Bioactive glass (BG) nanoparticles (BGNs) and hydrogels +have emerged as promising systems for drug delivery.[193] BGNs, +owing to th","[604, 149, 1098, 413]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +15,6,text,"Moving forward, hybrid drug delivery systems that combine two or more drug delivery methods have the potential to maintain drug bioactivity. It has been shown that combining a nanoparticle drug delive","[604, 410, 1099, 1204]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +15,7,paragraph_title,8. Conclusions and Future Directions,"[607, 1229, 967, 1254]",section_heading,0.85,"[""paragraph_title label with numbering: 8. Conclusions and Future Directions""]",section_heading,0.85,,heading_like,heading_numbered,True,True +15,8,text,"The field of composite biomaterials is continuously evolving, and researchers are investigating various directions to enhance their properties and expand their applications. The versatile nature of co","[605, 1267, 1099, 1446]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +15,9,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[98, 1487, 342, 1505]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +15,10,footer,2401218 (15 of 20),"[392, 1484, 535, 1507]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +15,11,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[586, 1487, 1097, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +15,12,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1155, 29, 1171, 1533]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False +16,0,header,"ADVANCED +SCIENCE NEWS +www.advancedsciencenews.com","[92, 46, 339, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +16,1,header,"ADVANCED HEALTHCARE MATERIALS +advhealthmat.de","[966, 40, 1091, 115]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +16,2,header,www.advhealthmat.de,"[920, 98, 1090, 116]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +16,3,text,"to the widespread clinical application of these exciting materials. Despite significant advancements, challenges remain in the development of biological tissue composites. The optimization of composit","[90, 148, 582, 326]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,4,text,I) Personalized composite biomaterials. Advancements in personalized medicine will likely drive the development of composite biomaterials tailored to individual patients. By utilizing patient-specific,"[104, 342, 581, 539]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,5,text,III) Luminescent composite biomaterials. The future of tissue repair and regeneration will benefit from enhanced bioimaging: luminescent composite biomaterials can be engineered to emit specific wavel,"[93, 693, 581, 868]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,6,text,"II) Bioresorbable electronics. Exploring composite biomaterials for the development of bioresorbable electronics, such as implantable sensors or drug delivery systems that dissolve safely in the body ","[98, 540, 582, 693]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,7,text,IV) Integration of smart materials and sensors. The incorporation of smart materials and sensors into composite biomaterials will enable real-time monitoring of physiological parameters and the delive,"[95, 869, 581, 1043]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,8,text,V) Multifunctional composite systems. The future will see the development of composite biomaterials that combine multiple functionalities within a single material system. These multifunctional composi,"[100, 1044, 581, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,9,paragraph_title,Keywords,"[603, 149, 701, 175]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Keywords""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +16,10,text,The authors declare no conflict of interest.,"[92, 1422, 377, 1442]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True +16,11,text,"bone tissue, cardiac tissue, cartilage tissue, composite biomaterials, electrical conductivity, magnetic stimulation, nerve tissue","[600, 186, 1090, 227]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,12,text,"Revised: June 13, 2024","[938, 268, 1091, 286]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,13,text,"Received: April 1, 2024","[937, 248, 1091, 267]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +16,14,paragraph_title,Conflict of Interest,"[92, 1384, 275, 1409]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflict of Interest""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True +16,15,text,"Published online: July 22, 2024","[883, 287, 1090, 307]",frontmatter_noise,0.6,"[""default body_paragraph for text label"", ""frontmatter_side_zone excluded from body flow""]",frontmatter_noise,0.6,frontmatter_side_zone,support_like,none,False,False +16,16,paragraph_title,Acknowledgements,"[92, 1275, 284, 1300]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +16,17,text,This research was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC) Grant # RGPIN2018-06310.,"[90, 1311, 580, 1352]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +16,18,reference_content,"[1] A. 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Express 2019, 5, 045038.","[605, 151, 1088, 189]",reference_item,0.85,"[""reference content label: [196] G. Jiang, B. Xu, J. Zhu, Y. Zhang, T. Liu, G. Song, Bi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +20,10,reference_content,"[197] M. Gou, X. Qu, W. Zhu, M. Xiang, J. Yang, K. Zhang, Y. Wei, S. Chen, Nat. Commun. 2014, https://doi.org/10.1038/ncomms4774.","[606, 191, 1088, 229]",reference_item,0.85,"[""reference content label: [197] M. Gou, X. Qu, W. Zhu, M. Xiang, J. Yang, K. Zhang, Y.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +20,11,reference_content,"[198] B. Xiao, E. Viennois, Q. Chen, L. Wang, M. K. Han, Y. Zhang, Z. Zhang, Y. Kang, Y. Wan, D. Merlin, ACS Nano 2018, 12, 5253.","[606, 231, 1088, 270]",reference_item,0.85,"[""reference content label: [198] B. Xiao, E. Viennois, Q. Chen, L. Wang, M. K. Han, Y. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +20,12,reference_content,"[199] Y. Zhang, J. Zhang, M. Chen, H. Gong, S. Thamphiwatana, L. Eckmann, W. Gao, L. Zhang, ACS Appl. Mater. Interfaces 2016, 8, 18367.","[606, 271, 1088, 327]",reference_item,0.85,"[""reference content label: [199] Y. Zhang, J. Zhang, M. Chen, H. Gong, S. Thamphiwatana""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +20,13,reference_content,"[200] Y. guang Bi, Z. Ting Lin, S. Ting Deng, Mater. Sci. Eng., C 2019, 100, 576.","[605, 331, 1089, 367]",reference_item,0.85,"[""reference content label: [200] Y. guang Bi, Z. Ting Lin, S. Ting Deng, Mater. Sci. En""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +20,14,reference_content,"[201] Z. Wang, Y. Wang, J. Yan, K. Zhang, F. Lin, L. Xiang, L. Deng, Z. Guan, W. Cui, H. Zhang, Adv. Drug Delivery Rev. 2021, 174, 504.","[604, 371, 1089, 409]",reference_item,0.85,"[""reference content label: [201] Z. Wang, Y. Wang, J. Yan, K. Zhang, F. Lin, L. Xiang, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +20,15,image,,"[115, 464, 316, 717]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +20,16,vision_footnote,"Milad Vahidi is a PhD candidate in the Department of Chemical and Biochemical Engineering at Western University, focusing on advanced functional biomaterials for bone tissue repair and regeneration. H","[326, 458, 1062, 592]",footnote,0.7,"[""vision_footnote label: Milad Vahidi is a PhD candidate in the Department of Chemica""]",footnote,0.7,,unknown_like,none,True,True +20,17,image,,"[114, 749, 314, 1007]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +20,18,vision_footnote,Amin S. Rizkalla is a professor at Western University in Schulich Dentistry; Chemical and Biochemical Engineering; Medical Biophysics; and Biomedical Engineering. His research area is in dental and or,"[326, 748, 1070, 903]",footnote,0.7,"[""vision_footnote label: Amin S. Rizkalla is a professor at Western University in Sch""]",footnote,0.7,reference_zone,reference_like,citation_line,True,True +20,19,image,,"[113, 1036, 315, 1293]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +20,20,text,"Kibret Mequanint is a Professor in the Department of Chemical and Biochemical Engineering and the School of Biomedical Engineering at the University of Western Ontario, Canada. His research interests ","[326, 1032, 1069, 1232]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +20,21,footer,"Adv. Healthcare Mater. 2024, 13, 2401218","[93, 1488, 336, 1504]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,22,footer,2401218 (20 of 20),"[387, 1485, 528, 1506]",noise,0.9,"[""footer label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False +20,23,footer,© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH,"[582, 1488, 1090, 1506]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +20,24,aside_text,"21922659, 2024, 27, Downloaded from https://advanced.onlinelibrary.wiley.com/doi/10.1002/adlm.202401218 by Shandong University Library, Wiley Online Library on [05/02/2026]. See the Terms and Conditio","[1156, 31, 1171, 1535]",noise,0.95,"[""margin-band narrow/tall geometry; treated as noise""]",noise,0.95,,unknown_like,none,False,False diff --git a/tests/fixtures/ocr_real_papers/KIX7SKXQ/block_trace.csv b/tests/fixtures/ocr_real_papers/KIX7SKXQ/block_trace.csv new file mode 100644 index 00000000..60f423b6 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/KIX7SKXQ/block_trace.csv @@ -0,0 +1,677 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,Materials Today • Volume 68 • September 2023,"[82, 58, 422, 80]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,1,header_image,,"[83, 118, 171, 216]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,2,header,RESEARCH,"[1079, 60, 1160, 77]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header_image,,"[1098, 120, 1154, 177]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,4,text,HIGHLIGHTED PAPER,"[454, 182, 800, 218]",authors,0.6,"[""page-1 initial-lastname author byline: HIGHLIGHTED PAPER""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,5,doc_title,Electrical stimulation system based on electroactive biomaterials for bone tissue engineering,"[76, 315, 1135, 496]",paper_title,0.8,"[""page-1 zone title_zone: Electrical stimulation system based on electroactive biomate""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,6,text,"Xiaodi Zhang $ ^{a,b} $, Tong Wang $ ^{a} $, Zhongyang Zhang $ ^{b} $, Haiqing Liu $ ^{d} $, Longfei Li $ ^{a} $, Aochen Wang $ ^{e} $, Jiang Ouyang $ ^{b} $, Tian Xie $ ^{f} $, Liqun Zhang $ ^{a,c} $","[81, 515, 1153, 584]",authors,0.8,"[""page-1 zone author_zone: Xiaodi Zhang $ ^{a,b} $, Tong Wang $ ^{a} $, Zhongyang Zhang""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text," $ ^{a} $ Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China","[79, 614, 848, 636]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $ Beijing Laboratory of Biomedical Materials, Beijing""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,8,text," $ ^{b} $ Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States + $ ^{c} $ State Key Laboratory of Organic-Inor","[80, 635, 1155, 673]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{b} $ Center for Nanomedicine and Department of Anesthesi""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,9,text," $ ^{d} $Department of Physiology, School of Clinical & Basic Medical Sciences (Institute of Basic Medical Sciences), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 25","[79, 676, 1153, 715]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{d} $Department of Physiology, School of Clinical & Basic""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,10,text," $ ^{e} $ College of Electronic Information and Automation, Tianjin University of Science and Technology, Tianjin 300222, China","[79, 715, 920, 734]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{e} $ College of Electronic Information and Automation, T""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,11,text," $ ^{f} $ College or Pharmacy, School or Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China","[79, 734, 841, 757]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{f} $ College or Pharmacy, School or Medicine, Hangzhou N""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,12,abstract,"Traumatic injuries can lead to large bone defects under extreme conditions, which usually take a long recovery period, while the prognosis is poor. Endogenous electric field, as one major biophysical ","[75, 780, 1156, 1253]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,13,aside_text,RESEARCH: Review,"[1185, 341, 1204, 481]",non_body_insert,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,short_fragment,False,False +1,14,text,Keywords: Bone tissue engineering; Electroactive materials; Piezoelectric materials; Conductive polymers; Carbon-based materials; Triboelectric nanogenerator; Ion channels,"[79, 1275, 1155, 1321]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: Bone tissue engineering; Electroactive materials; ""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,15,paragraph_title,Introduction,"[80, 1346, 209, 1368]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +1,16,text,"Bone is a complex calcified tissue with a highly hierarchical structure that plays a pivotal role in daily physiological activities, such as supporting the body, protecting internal organs, and mainta","[78, 1372, 605, 1445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,17,text,"maintaining hematopoiesis and mineral homeostasis [1,275]. +The bone naturally undergoes continuous self-renewal and heal- +ing by dynamically balancing osteoblastic bone-formation and +osteoclastic bone","[626, 1344, 1156, 1488]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,18,footnote,"* Corresponding authors. +E-mail addresses: Xue, J. (jiajaxue@mail.buct.edu.cn), Tao, W. (wtao@bwh.harvard.edu).","[87, 1471, 588, 1509]",footnote,0.7,"[""footnote label: * Corresponding authors.\nE-mail addresses: Xue, J. (jiajaxue""]",footnote,0.7,body_zone,body_like,none,True,True +1,19,footer,1369-7021/© 2023 Elsevier Ltd. All rights reserved. https://doi.org/10.1016/j.mattod.2023.06.011,"[81, 1529, 614, 1548]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,20,number,177,"[1123, 1531, 1154, 1549]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,0,aside_text,RESEARCH: Review,"[24, 341, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,short_fragment,False,True +2,1,header,RESEARCH,"[71, 61, 155, 80]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,header,Materials Today • Volume 68 • September 2023,"[802, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,3,text,"after the remodeling. However, clinical intervention will be necessary when the bone defect is over a critical size or in cases of poor osteogenesis conditions due to some diseases such as osteoporosi","[66, 122, 595, 433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"It is well known that the endogenous electric field (EnEF) plays a guiding role in embryogenesis, physiological activities, wound healing, tissue remodeling, and other biological processes, which are ","[67, 433, 596, 820]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"structure [14], which can convert the compressive load generated +by physiological activities into piezoelectric potential.","[615, 123, 1143, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"In this context, electroactive biomaterials (EABMs) have emerged. EABMs are a new generation of ""smart"" biomaterials capable of applying electrical stimulation (ES) directly to target cells or tissues","[613, 170, 1146, 819]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,image,,"[87, 888, 1121, 1443]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,8,figure_title,Schematic diagram of the piezoelectric properties of bone and the response of cells to electrical signals.,"[69, 1484, 803, 1509]",figure_caption_candidate,0.85,"[""figure_title label: Schematic diagram of the piezoelectric properties of bone an""]",figure_caption,0.85,body_zone,legend_like,none,False,False +2,9,number,178,"[71, 1536, 104, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 421, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,header,RESEARCH,"[1071, 61, 1154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,text,"ultrasound, mechanical vibrations, etc.) [33–37]. Thus, piezoelectric biomaterials exhibit great promise in tissue engineering. Besides, with a certain wavelength-dependent tissue penetration capabili","[78, 123, 605, 314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,"This review outlines the latest progress of EABMs in BTE. First, we start with the EnEF in bone tissue and highlight its guiding significance to various physiological activities of cells. Subsequently","[78, 315, 606, 651]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,paragraph_title,Endogenous and the interaction of electric signals with cells,"[78, 714, 577, 764]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Endogenous and the interaction of electric signals with cell""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,5,text,"Ever since Luigi Galvani's groundbreaking observation of muscle contractions through ES of the frog's sciatic nerve [43], a strong connection has been established between biology and electricity. This","[78, 768, 605, 1127]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"In recent years, there has been increasing attention towards harnessing EnEF or simulating them by applying exogenous electric field (ExEF) for therapeutic applications. Unlike the EnEF that naturally","[78, 1128, 606, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"Studying and understanding EnEF in living organisms will +help us accelerate tissue regeneration by applying exogenous +ES. Therefore, this chapter aims to explore EnEF in bone tissue +and show how elect","[626, 123, 1156, 266]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,paragraph_title,Piezoelectricity in bone tissue,"[629, 289, 883, 312]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Piezoelectricity in bone tissue""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,9,text,One of the most interesting types of EnEF is bio-piezoelectricity [47]. Piezoelectricity refers to the ability of a material to convert mechanical stimuli into electrical signals. Since the phenomenon,"[627, 315, 1155, 649]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"The piezoelectricity of bone tissue is attributed to collagen molecules with non-centrosymmetric structures, which are the most common naturally-derived piezoelectric biomaterials in the human body (F","[626, 651, 1156, 1344]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,Cellular response to electric signals,"[628, 1366, 932, 1389]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cellular response to electric signals""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +3,12,text,"ES has a long history in the treatment of fractures, dating back to the mid-nineteenth century. In recent years, with the advancements in ES therapy, its clinical implementation has demonstrated effec","[626, 1390, 1157, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,aside_text,RESEARCH: Review,"[1182, 342, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +3,14,number,179,"[1122, 1537, 1154, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,aside_text,RESEARCH: Review,"[25, 341, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +4,1,header,RESEARCH,"[71, 61, 155, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,header,Materials Today • Volume 68 • September 2023,"[802, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +4,3,text,"tures, and femoral osteonecrosis [58]. Recent studies have shed light on the effects of ES on cellular behaviors of stem cells or osteoblasts. ES has been found to mediate crucial processes such as pr","[67, 123, 594, 267]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,Cell proliferation and apoptosis,"[69, 292, 302, 313]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell proliferation and apoptosis""]",subsection_heading,0.6,body_zone,body_like,none,True,True +4,5,text,"A sufficient number of cells grown on bio-scaffolds is a prerequisite for achieving a satisfied healing effect in tissue engineering. The influence of ES on cell proliferation can vary, depending on t","[65, 316, 596, 1151]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,6,paragraph_title,Cell alignment,"[69, 1177, 183, 1198]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell alignment""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +4,7,text,"Cells in natural tissue are mostly arranged in an orderly manner. Therefore, replicating the ordered arrangement of cells on the scaffold can benefit its fusion with native tissues [66]. It has been c","[66, 1198, 595, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,text,"triphosphate (ATP) and free calcium will further increase the +contractility of the cytoskeleton, leading to cell detachment from +its focal adhesions (FA). The cytoskeletal contraction squeezes +the cyt","[615, 123, 1145, 435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,Cell migration,"[618, 458, 729, 479]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell migration""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +4,10,text,"Inducing the migration of endogenous cells to the wound site is conducive to the recruitment of cells during healing. This process is generally driven by the EnEF generated at the wound site, while ap","[614, 482, 1145, 912]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,11,paragraph_title,Cell adhesion,"[618, 936, 724, 957]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell adhesion""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +4,12,text,"Cell adhesion is mainly used to describe the interaction between the cytoskeleton and ECM, where FA is crucial in this connection. External electromechanical stimulation will cause the rearrangement o","[614, 959, 1145, 1319]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,paragraph_title,Osteogenic differentiation,"[618, 1343, 812, 1365]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Osteogenic differentiation""]",subsection_heading,0.6,body_zone,body_like,none,True,True +4,14,text,"In view of the electroactivity of bone, numerous pieces of evidence has proved that various forms of ES are beneficial to osteogenic commitments [79–83]. Exogenous ES, mainly including DC, AC, capacit","[614, 1366, 1145, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,15,number,180,"[72, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 421, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +5,1,header,RESEARCH,"[1071, 61, 1154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,text,tion of stem cells [84–88]. Representative works and underlying mechanisms of this part will be discussed in detail in Chapter 4 and 5.,"[78, 123, 605, 192]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,paragraph_title,Electroactive biomaterials for bone tissue Engineering: General classification,"[79, 223, 491, 275]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electroactive biomaterials for bone tissue Engineering: Gene""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,4,footer,,"[79, 250, 430, 275]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +5,5,text,"According to the source of electrical signals, in this section, we mainly introduce the following two kinds of EABMs (Fig. 2): (i) conductive biomaterials that can transmit electrical signals and (ii)","[79, 279, 605, 421]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,6,paragraph_title,Conductive biomaterials,"[80, 442, 291, 465]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conductive biomaterials""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +5,7,text,"Conductive biomaterials can possess versatile properties in additional to excellent electrical conductivity, which endows them with potential values in BTE. Whereas, they also exhibit shortages to som","[78, 467, 606, 756]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,8,paragraph_title,Carbon-based nanomaterials,"[80, 776, 295, 797]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Carbon-based nanomaterials""]",subsection_heading,0.6,body_zone,body_like,none,True,True +5,9,text,"Carbon nanotubes. Carbon nanotubes, both single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), have cylindrical carbon structures that endow them with large surface areas","[77, 799, 606, 1039]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,text,"properties (Young’s modulus up to 1 TPa and tensile strength +of 63 GPa). Moreover, the multi-layered structure of MWCNTs +can preserve their high conductivity even with several surface +modifications, wh","[626, 124, 1157, 360]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,11,text,"Despite the as-explored promising applications in biomedical engineering, the safety of CNTs has been a constant source of vigilance. In a recent report, CNTs were added to the SIN ('Substitute It Now","[626, 362, 1156, 671]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,12,text,"Graphene and its derivatives. Graphene has attracted enormous interest since it was obtained through mechanical exfoliation from graphite in 2004 [91]. Similar to SWCNTs, graphene, with sp² hybridized","[626, 674, 1156, 1032]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,13,image,,"[93, 1072, 1136, 1454]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,figure_title,General classification of electroactive biological materials for tissue engineering.,"[81, 1485, 643, 1509]",figure_caption_candidate,0.85,"[""figure_title label: General classification of electroactive biological materials""]",figure_caption,0.85,body_zone,legend_like,none,False,False +5,15,aside_text,RESEARCH: Review,"[1182, 341, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +5,16,number,181,"[1122, 1536, 1153, 1555]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,aside_text,RESEARCH: Review,"[25, 342, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +6,1,header,RESEARCH,"[71, 61, 154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +6,3,text,"[102], and good biocompatibility, enable it to have a wide application prospect in the biomedical field. Nowadays, graphene quantum dots [103], graphene nanoribbons [104,105], monolayer/few-layered gr","[66, 122, 594, 600]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_bracket,True,True +6,4,text,"While graphene is excreted by the kidney through blood circulation $ [108,109] $, it can also be absorbed by other organs, such as the brain, heart, liver, lung, etc. $ [108,110] $. Cytotoxicity of ","[67, 601, 594, 889]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,5,paragraph_title,Conducting polymers,"[69, 938, 229, 958]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conducting polymers""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +6,6,text,Conducting polymers (CPs) are defined as a class of organic materials that not only have unique electrical and optical properties similar to metals and semiconductors but also exhibit attractive prope,"[67, 960, 595, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"delivery devices, as well as constructing electroactive scaffolds +for tissue engineering.","[617, 123, 1143, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,text,The charge-conducting ability of CPs is attributed to electrons jumping within and between the polymer chains. Conjugated systems in CPs are composed of $ \pi $ molecular orbitals formed by overlappi,"[615, 171, 1145, 625]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,9,text,"Polypyrrole (PPy). PPy and its derivatives, one class of the most widely studied CPs, have demonstrated potential for biomedical applications especially in tissue engineering, electro-responsive drug ","[615, 626, 1145, 912]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"Polyaniline (PANi). Polyaniline, mainly existing in three forms including fully oxidized (pernigraniline base), half oxidized (emeraldine base) and completely reduced (leucoemeraldine), has also been ","[615, 913, 1145, 1150]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,text,"Poly(3,4-ethyl-enedioxythiophene) (PEDOT). PEDOT, a derivative of PTH, is a relatively young class of conductive polymers with excellent electrical conductivity, as well as good chemical and thermal s","[615, 1151, 1145, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,12,number,182,"[72, 1536, 103, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 421, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +7,1,header,RESEARCH,"[1071, 61, 1154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,paragraph_title,Metallic conductive materials,"[80, 124, 296, 144]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metallic conductive materials""]",subsection_heading,0.6,body_zone,body_like,none,True,True +7,3,text,"Titanium (Ti), cobalt (Co), magnesium (Mg), and their alloys, as well as stainless steel, are currently employed in clinical for the fabrication of implantable bone scaffolds. These metallic materials","[78, 146, 606, 478]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"Metal nanoparticles offer a combination of the exceptional electrical and thermal conductivity of metal materials, along with the distinct physicochemical properties of nanomaterials. Among them, gold","[78, 481, 605, 911]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"Gold nanomaerials (AuNMs). AuNMs exhibit excellent biocompatibility, easy to adjust surface properties through surface functionalization, adjustable size and shape (like nanoclusters, nanocages, nanor","[78, 912, 605, 1197]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Silver nanomaterials (AgNMs). Compared with AuNMs, AgNMs have better electrical and thermal conductivity properties. In addition, AgNMs have unique antibacterial properties, exhibiting strong antibact","[78, 1199, 605, 1414]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,paragraph_title,Mxene,"[79, 1441, 138, 1460]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Mxene""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +7,8,text,"In recent years, MXene has emerged as a promising two-dimensional nanomaterial, displaying exceptional electrical conductivity, high volume capacitance, excellent mechanical properties, and optical pr","[78, 1463, 605, 1509]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"ductivity, high volume capacitance, excellent mechanical prop- +erties, and optical properties. The presence of surface +termination groups facilitates its dispersion in aqueous phases +and organic solve","[627, 124, 1156, 456]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,"The outstanding conductive properties of MXene can be attributed to several factors. Firstly, MXene encompasses transition metals, which inherently possess metallic properties, thus endowing them with","[626, 458, 1156, 890]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,paragraph_title,Piezoelectric materials,"[629, 913, 823, 935]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Piezoelectric materials""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +7,12,text,"Piezoelectric material is a kind of material that can achieve electromechanical conversion. As a result, piezoelectric materials can regenerate local electrical signals in situ without the need for el","[626, 938, 1156, 1248]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,13,paragraph_title,Piezoceramics,"[629, 1272, 737, 1293]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Piezoceramics""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +7,14,text,"Most piezoceramics have very high piezoelectric coefficients, so they have been widely used in electronics, especially lead zirconate titanate (PZT) with a piezoelectric coefficient reaching up to 200","[626, 1295, 1156, 1461]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,15,text,"Perovskite structure belongs to the cubic crystal system, and the general chemical formula is $ ABO_{3} $ [148]. Except above men-","[629, 1464, 1157, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,16,aside_text,RESEARCH: Review,"[1183, 342, 1199, 480]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +7,17,number,183,"[1122, 1537, 1153, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,aside_text,RESEARCH: Review,"[25, 341, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +8,1,header,RESEARCH,"[71, 61, 154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +8,3,text,"tioned PZT, other common piezoceramics including BaTiO₃ (d₃₃ = 191 pC/N), BiFeO₃, LiNbO₃ (d₃₃ = 23 pC/N), MgSiO₃ (d₃₁ = 1.74 pC/N), potassium sodium niobate (KNN) (d₃₃ = 63 pC/N), lithium sodium potas","[67, 124, 594, 480]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"Although piezoceramics have excellent piezoelectric properties, their applications in bone regeneration are always hindered by poor toughness and distortion resistance. Instead, they are usually used ","[67, 483, 594, 601]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,paragraph_title,Piezoelectric polymers,"[69, 652, 232, 672]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Piezoelectric polymers""]",subsection_heading,0.6,body_zone,body_like,none,True,True +8,6,text,"Although the piezoelectric properties of piezoelectric polymers are not as good as piezoceramics, they have better mechanical properties and biocompatibility, and can be processed in a variety of ways","[67, 673, 594, 1008]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_side_zone,body_like,none,True,True +8,7,text,"PVDF and its copolymers are one of the most investigated bio-piezoelectric polymers. Although PVDF is composed of $ -CH_{2}-CF_{2}-monomer $, different arrangements of hydrogen and fluorine atoms lea","[67, 1009, 594, 1509]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"PLLA is another commonly used piezoelectric polymer, which +has better biocompatibility and biodegradability than PVDF. Its +piezoelectricity is similar to that of human bones, and its shear +piezoelectr","[615, 123, 1144, 383]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,9,text,"Although piezoelectric polymers have better processability and flexibility, their piezoelectric coefficients are relatively lower compared to that of piezoceramics. Therefore, piezoelectric composite ","[616, 385, 1145, 530]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,paragraph_title,Application in bone healing,"[618, 566, 898, 591]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Application in bone healing""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +8,11,text,"The process of bone healing is usually divided into the following four consecutive stages: inflammation, fibrogenic callus formation, bone formation, and bone reconstruction/remodeling [1]. A variety ","[615, 594, 1145, 784]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,text,"It is worth noting that although cartilage does not belong to the bone tissue, it plays a pivotal role in the process of osteogenesis. During embryonic development, non-long bones, such as the skull a","[615, 786, 1146, 1335]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,13,paragraph_title,Osteogenesis,"[619, 1366, 737, 1388]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Osteogenesis""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +8,14,text,"Electroactive scaffolds with electrical conductivity have been shown to promote osteogenesis by enhancing intercellular communication in the presence of EnEF. However, in most studies in these years, ","[615, 1390, 1146, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,number,184,"[72, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 422, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +9,1,header,RESEARCH,"[1071, 61, 1154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,2,text,"on the application of electroactive scaffolds to promote osteogenesis only rely on presence of EnEF and potential difference in situ, without external ES. The references of electrical properties of el","[77, 123, 606, 290]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,3,text,"Conductive polymers, as emerging conductive materials, are attempted to be used as conductive scaffolds for bone tissue engineering. The electrical conductivity of the fibrous mesh reached $ 0.094 \p","[77, 290, 607, 914]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"was obtained. Under physiologically relevant low frequencies, +the impedance of GelMA-PANi was significantly lower than that +of pure GelMA, and based on this conductive hydrogel, a +microstructure can be","[626, 123, 1156, 457]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,text,"Carbon-based nanomaterials have also been shown to interact with osteoblasts to induce bone calcification. A composite material consisting of CNTs, HAp, and bioactive glass nanoparticles (BAG NPs) was","[624, 458, 1157, 915]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,6,figure_title,TABLE 1,"[80, 955, 145, 975]",table_caption,0.9,"[""table prefix matched: TABLE 1""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +9,7,table,"
Electrical properties of electroactive scaffolds and their effects on bone healing in the absence of exogenous stimuli.
Electroactive materialsElec","[81, 983, 1153, 1507]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +9,8,aside_text,RESEARCH: Review,"[1182, 341, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +9,9,number,185,"[1122, 1536, 1154, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,RESEARCH,"[72, 62, 153, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,1,aside_text,RESEARCH: Review,"[25, 341, 42, 484]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +10,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +10,3,image,,"[72, 134, 1122, 939]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,4,figure_title,"Electroactive materials for osteogenesis without the present of external electrical stimulation. a) Schematic diagram of GelMA-Pani produced by digital projection micro-stereolithography, as well as b","[68, 972, 1145, 1134]",figure_caption_candidate,0.85,"[""figure_title label: Electroactive materials for osteogenesis without the present""]",figure_caption,0.85,body_zone,support_like,none,False,False +10,5,text,membrane with a core–shell structure demonstrates enhanced adhesion properties for hMSCs [163].,"[68, 1169, 593, 1215]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,text,"As bone implants, redox reactions on carbon steel surfaces may cause adverse effects such as corrosion, release of metal ions, biocompatibility issues, and impaired mechanical properties. As shown in ","[67, 1217, 594, 1454]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,7,text,"As natural bones have piezoelectricity, piezoelectric materials that can respond to physiological loads and generate electric fields inside bone tissue, making them theoretically more suitable for bon","[68, 1456, 595, 1503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,8,text,"fields inside bone tissue, making them theoretically more suit- +able for bone regeneration. Generally, the bone compression area +generates an endogenous negative potential, while the negative +potential","[615, 1169, 1145, 1287]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,9,text,"Barium titanate (BT) with a high piezoelectrical coefficient is the most popular piezoelectric ceramic, which is usually used for preparing piezoelectric composites. For example, polydopamine (PDA, Do","[615, 1288, 1146, 1504]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,10,number,186,"[72, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 421, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +11,1,header,RESEARCH,"[1071, 61, 1154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,2,text,"Compared with pure P(VDF-TrFE) film, the piezoelectric film doped with 5% BT NPs showed a better healing outcome in rat calvarial models [165]. BT can also be prepared in the form of nanofibers by ele","[78, 122, 607, 576]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,3,text,"ZnO is also a common EABM used for bone repair. Like most nanoparticles, the biotoxicity of ZnO is also dose-dependent, which led to reduced cell viability of MSCs when its concentration reaches 60 µg","[78, 578, 605, 816]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"Besides, other piezoceramics have been applied in bone repair as well. For instance, a negative charge on the surface of lithium sodium potassium niobate porous scaffold can promote FA and proliferati","[79, 819, 605, 1198]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"Electrospinning is a well-known and attractive nanofabrication technique, which has been widely used for fabricating nanostructures with piezoelectric polymers. Compared with the film prepared by spin","[78, 1200, 606, 1512]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,"closer to the cell membrane potential (MG63: 60 mV), pro- +moted the formation and mineralization of collagen [174]. +Biodegradable PLLA scaffold can also be used to enhance bone +regeneration [175]. Com","[626, 123, 1155, 433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,text,"In fact, one thing that needs to be faced squarely is that piezoelectric polymers usually do not have supporting capabilities. Most recent studies are limited to in vitro experiments. Even if in vivo ","[627, 435, 1155, 624]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,8,paragraph_title,Chondrogenesis,"[630, 648, 772, 671]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Chondrogenesis""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +11,9,text,"Except for lamellar bones such as the skull, the development and repair of other long bones in the human body need to undergo endochondral ossification. The chondrocytes differentiated from stem cells","[626, 674, 1156, 1055]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,text,3D flexible nanofiber P(VDF-TrFE) scaffold was the first piezoelectric scaffold for evaluating the differentiation of MSC towards cartilage and bone cells (Fig. 4a). A dynamic load with a frequency of,"[626, 1058, 1156, 1414]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,text,"Conductive materials, such as GO, can be added to polymeric nanofibers to improve electrical output and mechanical properties. After doping GO, the PLLA scaffold was further coated with PDA to enhance","[626, 1415, 1155, 1509]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,12,aside_text,RESEARCH: Review,"[1183, 342, 1199, 480]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,13,number,187,"[1123, 1537, 1153, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,aside_text,RESEARCH: Review,"[25, 341, 41, 484]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +12,1,header,RESEARCH,"[72, 62, 154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +12,3,image,,"[76, 126, 1121, 804]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +12,4,figure_title,"The role of electroactive biomaterials in promoting other aspects during bone healing process. a) Representative images and histological evaluations of aspun PVDF-TrFE, annealed PVDF-TrFE and PCL scaf","[66, 840, 1146, 981]",figure_caption_candidate,0.85,"[""figure_title label: The role of electroactive biomaterials in promoting other as""]",figure_caption,0.85,body_zone,support_like,none,False,False +12,5,text,"the scaffold under dynamic mechanical loads promoted prechondrogenic cells to synthesize more glycosaminoglycans and differentiate to the chondrogenic phenotype [188]. Similarly, absorbable collagen s","[67, 1027, 595, 1171]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,text,It can be speculated from the very limited available works that the electrical signals required for chondrogenic differentiation could be weaker than that for osteogenic differentiation. Considering t,"[66, 1172, 594, 1339]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,paragraph_title,Vascularization,"[69, 1367, 204, 1388]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Vascularization""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +12,8,text,"One of the crucial issues for fracture healing is angiogenesis, especially in open fractures, poor blood supply can lead to a higher risk of fracture nonunion. New blood vessels can bring nutrients, m","[67, 1390, 594, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,"tissue regeneration [190,191]. It is worth noting that blood ves- +sels also retain piezoelectric properties, Fukada and Hara found +piezoelectricity in aorta and vena in 1969 [192], which are +mainly at","[615, 1027, 1146, 1507]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,10,number,188,"[72, 1536, 103, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 421, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +13,1,header,RESEARCH,"[1071, 61, 1154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,2,text,"dependent increase. It has been confirmed that the VEGFR2 signaling pathway is important for promoting endothelial cell angiogenesis [196]. In addition, activation of endothelial nitric oxide synthase","[79, 123, 606, 360]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,text,"In addition, ES can promote angiogenesis by promoting the release of active factors in the electroactive scaffold. In a study on promoting osteoporotic bone regeneration with ES, a conductive biocompo","[78, 363, 605, 744]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,paragraph_title,Anti-bacteria,"[79, 769, 197, 790]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Anti-bacteria""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,5,text,"For open fractures, wound infection will not only hinder the healing progress, leading to bone nonunion, but also increase the risks of subsequent deep infections, such as osteomyelitis. Therefore, th","[78, 793, 606, 1198]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,6,text,Doping the piezoelectric phase Na₀.₅K₀.₅NbO₃ in 1392 BAG could reduce the population of bacteria while promoting the viability of MG-63 cells. Polarized composite material with static surface electric,"[77, 1201, 606, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,text,"on positively polarized HAp-BT composites [208]. Another study +working on ZnO/PVDF composite nanofiber scaffold also proved +that piezoelectric excitation in the scaffold could inhibit the +growth of bac","[626, 123, 1156, 553]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,8,paragraph_title,Drug delivery,"[629, 576, 752, 599]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Drug delivery""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +13,9,text,"The principle for utilizing CP for electro-responsive drug delivery is based on the switch of polymers between oxidized and reduced states, which enables the capture and release of charged molecules t","[627, 601, 1156, 816]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,10,text,"For healing bone defects caused by major amputation or disease, the controlled release of bioactive effectors at the bone defect conduces to promote osteogenesis. As shown in Fig. 4d, the electroactiv","[626, 818, 1156, 1102]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,11,text,"However, CP-based drug delivery systems usually face challenges such as limited drug selection range by polarity and molecular weight and finite loading capacity. Therefore, electrically responsive mi","[626, 1104, 1156, 1389]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,12,text,"The drug release from piezoelectric-based carriers is mostly based on micropumps, due to their better controllability, accuracy, and reliability. However, previous studies have mainly focused on insul","[626, 1391, 1156, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,13,aside_text,RESEARCH: Review,"[1182, 342, 1199, 480]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +13,14,number,189,"[1123, 1537, 1154, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,0,aside_text,RESEARCH: Review,"[25, 342, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +14,1,header,RESEARCH,"[71, 61, 154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +14,3,text,"motion, and research on drug delivery related to electrical properties remains to be explored. It has been mentioned that the piezoelectricity of the scaffold is used to increase the loading capacity ","[67, 123, 594, 340]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,4,paragraph_title,"Electrical stimulations in bone tissue engineering +Exogenous electrical stimulation","[68, 385, 555, 432]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrical stimulations in bone tissue engineering\nExogenous""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +14,5,text,"Exogenous ES equipment has been used clinically to treat fracture healing, nonunion, and osteoporosis and enhance spinal fusion. Current clinical-use ES devices are usually divided into two modes: inv","[67, 432, 594, 1296]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,text,"In most in vitro studies, invasive ES is performed by directly immersing electrodes in the culture medium. According to different commercial electric stimulators, most of the applied electrical signal","[67, 1296, 594, 1461]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,7,text,"In the aforementioned work of treating osteoporotic fractures, the electrodes were tightly integrated with conductive rGO/zinc silicate/calcium silicate (rGO/ZS/CS) biocomposites scaffold, and Keithle","[68, 1463, 594, 1509]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,8,text,"silicate/calcium silicate (rGO/ZS/CS) biocomposites scaffold, and +Keithley (2400) was used as a power supply to provide bMSCs +with a direct current of 3 lA for 1 h per day (Fig. 5a) [198]. Keith- +ley ","[615, 121, 1145, 601]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,9,text,The application of pulsed electrical signals can solve the hyperthermia side-effect caused by DC [226]. BMSCs cultured on conductive poly[(alanine ethyl ester)-(glycine ethyl ester)] phosphazene/CNT (,"[614, 602, 1146, 1248]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,10,text,"There are also some works that provide ES parameters based on AC electric field density. For example, a carbon electrode was placed in a culture plate, and MC3T3 cells on CNT-PEG-acrylate and black ph","[614, 1247, 1145, 1460]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,11,text,Salt bridge is another invasive ES method. The salt bridge can separate cells from metallic electrodes to avoid excessive electro-,"[617, 1463, 1145, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,12,number,190,"[72, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 422, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +15,1,header,RESEARCH,"[1071, 61, 1154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,2,figure_title,TABLE 2,"[81, 123, 144, 143]",table_caption,0.9,"[""table prefix matched: TABLE 2""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +15,3,figure_title,Effects of electroactive scaffolds on bone healing in the presence of exogenous electrical stimulation and electrical stimulation parameters.,"[82, 150, 1093, 172]",figure_caption,0.85,"[""figure_title label: Effects of electroactive scaffolds on bone healing in the pr""]",figure_caption,0.85,body_zone,legend_like,none,True,True +15,4,table,"
Application modeElectroactive materialsES parametersEffectRefs.
DC ESDiamond-Graphite Nanoplatelet3 $","[84, 159, 1142, 829]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +15,5,text,"chemical reaction products. As shown in Fig. 5b, bio-agar salt bridges with a T-shaped structure were used to replace metallic electrodes. To ensure the uniform distribution of the electric field on e","[78, 871, 606, 1180]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,6,text,"There are also several works that use non-invasive ES. In a study investigating how ES affects bone formation on 3D PCL/CNT and PCL/β-tricalcium phosphate (TCP) composite materials, the electrode cult","[77, 1181, 607, 1492]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,7,text,"tive effects of external magnetic forces on osteogenesis, it has +also been confirmed that IC stimulation led to an additional pro- +motion of osteogenesis (Fig. 5d) [235]. Another way to achieve +non-inv","[626, 870, 1157, 1111]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,8,paragraph_title,"Self-powdered electrical signal source +Piezoelectric nanogenerators (PENG)","[628, 1154, 950, 1198]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Self-powdered electrical signal source\nPiezoelectric nanogen""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +15,9,text,"Piezoelectric materials can regulate cell behavior by providing different forms of electrical signals. Piezoelectric materials with surface charges/potential after polarization were firstly studied, m","[627, 1200, 1157, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,10,aside_text,RESEARCH: Review,"[1182, 342, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +15,11,number,191,"[1122, 1536, 1153, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,0,aside_text,RESEARCH: Review,"[25, 341, 42, 483]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +16,1,header,RESEARCH,"[72, 61, 154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +16,3,image,,"[82, 133, 1116, 973]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,4,figure_title,"A) bone regeneration activity is enhanced when 3 µa direct current stimulates mbmscs cultured on the surface of rgo/zs/cs. Reproduced with permission[198]. Copyright 2017, American Chemical Society. b","[68, 1012, 1145, 1114]",figure_caption_candidate,0.85,"[""figure_title label: A) bone regeneration activity is enhanced when 3 \u00b5a direct c""]",figure_caption,0.85,body_zone,support_like,none,False,False +16,5,text,electrical stimulation generated by PENG and demonstrated their role in bone healing in Table 3.,"[68, 1167, 593, 1212]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,text,Some studies suggest that negatively charged surfaces can stimulate cell adhesion and growth. HAp/BT piezocomposites with negative charges on the surface after electric polarization could induce the a,"[67, 1215, 594, 1502]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,7,text,"some works exploring the effect of quantified surface potential +on osteogenic differentiation. By controlling the spontaneous +polarization direction and magnitude of GaN, two films of N- +GaN/AlGaN with ","[615, 1166, 1146, 1503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,8,number,192,"[71, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 422, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +17,1,header,RESEARCH,"[1071, 61, 1154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,2,figure_title,TABLE 3,"[81, 123, 144, 142]",table_caption,0.9,"[""table prefix matched: TABLE 3""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +17,3,figure_title,Effects of in situ electrical stimulation generated by piezoelectric materials on bone healing.,"[82, 150, 754, 172]",figure_caption,0.85,"[""figure_title label: Effects of in situ electrical stimulation generated by piezo""]",figure_caption,0.85,body_zone,legend_like,none,True,True +17,4,table,"
Effects of in situ electrical stimulation generated by piezoelectric materials on bone healing.
Trigger modeElectroactive materialsPiezoel","[82, 155, 1140, 1493]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +17,5,aside_text,RESEARCH: Review,"[1182, 341, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +17,6,number,193,"[1123, 1537, 1153, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,0,aside_text,RESEARCH: Review,"[25, 341, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +18,1,header,RESEARCH,"[72, 61, 154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +18,3,figure_title,TABLE 3 (CONTINUED),"[71, 126, 224, 145]",table_caption,0.9,"[""table prefix matched: TABLE 3 (CONTINUED)""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +18,4,table,"
Trigger modeElectroactive materialsPiezoelectric effectEffectHighlightsRef.
MagnetostrictionWhitlockit","[75, 149, 1137, 427]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +18,5,figure_title,(b),"[543, 559, 572, 582]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +18,6,image,,"[85, 546, 1125, 1192]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +18,7,paragraph_title,FIG. 6,"[73, 1200, 123, 1219]",figure_caption,0.9,"[""figure prefix matched: FIG. 6""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +18,8,figure_title,"A) schematic diagram of the response of polarized and non-polarized surfaces to cell-material interactions. Reproduced with permission [237]. Copyright 2013, Wiley-VCH. b) GaN/AlGaN films with surface","[69, 1224, 1144, 1346]",figure_caption_candidate,0.85,"[""figure_title label: A) schematic diagram of the response of polarized and non-po""]",figure_caption,0.85,body_zone,support_like,none,False,False +18,9,text,"PLGA film and MXene/PVDF film with a surface potential of $ -76.8\ mV $, $ -58.2 $ to $ 60.9\ mV $ and $ -58.6 $ to $ -74.58\ mV $, respectively [165,240,241].","[68, 1381, 594, 1450]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,10,text,"However, some studies hold the opposite view, suggesting that positively charged surfaces are more favor to bone formation. In the same polarized lithium niobate, better cell adhesion and spread capab","[69, 1453, 594, 1500]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,11,text,"tion. In the same polarized lithium niobate, better cell adhesion +and spread capabilities were observed on its positively charged +surface. By measuring proteins adsorbed on the charged surface, +more p","[616, 1382, 1145, 1500]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,12,number,194,"[72, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 422, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +19,1,header,RESEARCH,"[1071, 61, 1154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,2,text,"showed negatively charged in osteogenic induction medium, thereby enhancing the osteogenic differentiation of bMSCs (Fig. 6c) [171]. Besides, there is another speculation on the mechanism by which pos","[77, 122, 606, 553]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,3,text,"Although there are different opinions on the effects of positive and negative charges on cellular behaviors, it is certain that both charged surfaces can increase cell activity. This opinion has also ","[78, 554, 606, 792]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,4,text,There are also some piezoelectric materials that are intrinsically neutral and only generate an electric charge/potential in response to a force. The magnitude of the piezoelectric signal generated in,"[78, 793, 605, 982]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,5,text,Cell traction. It is well known that the intracellular tension generated during cell spreading and migration can be anchored to the substrate through actin and stress fibers. This traction force is us,"[78, 984, 606, 1293]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,6,text,Constant cyclic stress. External dynamic loads can also be used to simulate the physiological load generated by the human body's daily activities to trigger the piezoelectricity of materials. As shown,"[78, 1295, 606, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,7,text,"soidal waveform at 1 Hz was used to apply dynamic compressive +stress of 10% compression deformation to the 3D nanofiber scaf- +fold. The streaming potentials of annealed P(VDF-TrFE) was 61. +1 ± 1.5 lV, ","[626, 123, 1156, 290]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,8,text,"US stimulation. As a non-invasive approach, US has deep tissue penetration and biological safety, and can be used to trigger piezoelectric effects remotely and accurately. US has been applied to PLLA ","[627, 291, 1156, 624]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,9,text,"Magnetostriction. Extensive studies have demonstrated that stem cells can achieve osteogenic differentiation, chondrogenic differentiation, and neural differentiation in response to electromagnetic fi","[626, 626, 1157, 1127]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,10,paragraph_title,Triboelectric nanogenerators (TENG),"[630, 1153, 894, 1174]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Triboelectric nanogenerators (TENG)""]",subsection_heading,0.6,body_zone,body_like,none,True,True +19,11,text,"Since the flexible TENG was proposed in 2012, it has been regarded as a hope in the field of biosensors and implantable self-powered medical devices because of its highly efficient electromechanical c","[626, 1176, 1157, 1512]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,12,aside_text,RESEARCH: Review,"[1182, 342, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +19,13,number,195,"[1123, 1536, 1153, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,0,header,RESEARCH,"[72, 61, 154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,1,aside_text,RESEARCH: Review,"[25, 342, 42, 484]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +20,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +20,3,image,,"[70, 125, 1125, 803]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,4,figure_title,"A) saos-2 cells growing on zinc oxide nanosheets trigger the piezoelectric effect through their own traction. Reproduced with permission[169]. Copyright 2020, Wiley-VCH. b) The piezoelectric effect is","[68, 838, 1143, 942]",figure_caption_candidate,0.85,"[""figure_title label: A) saos-2 cells growing on zinc oxide nanosheets trigger the""]",figure_caption,0.85,body_zone,support_like,none,False,False +20,5,text,"of a heartbeat, convert it into electrical energy, store it, and then apply it to the pacemaker [254,255].","[68, 961, 593, 1007]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,6,text,The first study using TENG to induce bone formation was achieved by seeding MC3T3-E1 cells on the interdigitated electrode. The rectified output current generated by TENG could reach 1.6 $ \mu $A. As,"[67, 1008, 595, 1461]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,7,text,"Bioresorbable self-powered devices, fracture ES devices (FED), have been developed, which can convert body movement into biphasic electrical pulses, which are directly applied to the fracture site thr","[68, 1462, 594, 1509]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,8,text,"biphasic electrical pulses, which are directly applied to the frac- +ture site through dressing electrodes. With the help of FED, the +tibial fracture of the rat fully recovered within six weeks and +mai","[615, 961, 1145, 1078]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,9,text,"The aging of bones can seriously affect the life quality of the elders, especially leading to osteoporosis-related fractures, which increase the risk of death. The main reason is the decline in the fu","[615, 1080, 1145, 1390]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,10,paragraph_title,Other implantable energy harvesting devices,"[619, 1416, 945, 1437]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Other implantable energy harvesting devices""]",subsection_heading,0.6,body_zone,body_like,none,True,True +20,11,text,"In addition to PENG and TENG, which can convert the body's mechanical energy into electrical energy, there are other implantable energy harvesting devices that can collect ambient light or","[617, 1436, 1145, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,12,number,196,"[72, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,0,header,Materials Today • Volume 68 • September 2023,"[82, 62, 421, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +21,1,header,RESEARCH,"[1072, 62, 1153, 78]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,2,image,,"[101, 125, 1128, 754]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +21,3,figure_title,FIG. 8,"[85, 774, 135, 792]",figure_caption,0.92,"[""figure_title label: FIG. 8""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +21,4,figure_title,"A) teng can rejuvenate the aging mesenchymal stem cells[257]. Copyright 2021, Wiley-VCH. b) The ES of photovoltaic cells induces cytosolic Ca²⁺ transients to promote the adhesion and growth of Saos-2 ","[78, 797, 1156, 880]",figure_caption_candidate,0.85,"[""figure_title label: A) teng can rejuvenate the aging mesenchymal stem cells[257]""]",figure_caption,0.85,body_zone,support_like,none,False,False +21,5,text,temperature or in vivo redox reactions and convert them into electrical signals.,"[79, 917, 604, 961]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,6,text,"Due to the biosafety of light, light-induced electrical signals have also been applied in the field of bone regeneration. Photovoltaic solar cells have been widely studied as green energy sources. The","[79, 962, 606, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,7,text,"Ti metal, as a load-bearing bone material that has been used in the clinic, still has the problem of insufficient bioactivity, which results in limited osseointegration. The bioactivity of Ti implants","[79, 1442, 605, 1489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,8,text,"results in limited osseointegration. The bioactivity of Ti implants +can be improved by imparting electrical activity to their surface. +Studies have shown that collagen and HAp could form a semi- +condu","[627, 915, 1156, 1368]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,9,text,"The biggest challenge in applying light to tissue engineering is the penetrability of light. Most optoelectronic materials respond to ultraviolet light and visible light, but the tissue penetration de","[626, 1370, 1156, 1490]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,10,aside_text,RESEARCH: Review,"[1182, 342, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +21,11,number,197,"[1123, 1536, 1153, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,0,aside_text,RESEARCH: Review,"[25, 341, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +22,1,header,RESEARCH,"[71, 60, 154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +22,3,text,"has been proposed for the treatment of bone regeneration and fracture healing. Compared with other visible light, red light (635 nm) has better tissue penetration. With a strong nonlinear optical effe","[66, 123, 594, 457]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,4,paragraph_title,ES-induced cell response—mechanisms,"[68, 507, 457, 529]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: ES-induced cell response\u2014mechanisms""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +22,5,text,"Regardless of the application of exogenous current and electric field, the surface charge and built-in potential generated in situ, generally regulate cellular behaviors through biological processes m","[67, 534, 593, 679]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,6,paragraph_title,Calcium signaling in cells,"[69, 721, 289, 743]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Calcium signaling in cells""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +22,7,text,"The immediate effect of ES on cells is the intracellular Ca²⁺ levels, which mediates many crucial cellular processes, such as apoptosis, migration, proliferation, and differentiation [264]. When cells","[66, 745, 594, 1007]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,8,text,"According to membrane potentials, voltage-operated calcium channels are divided into low voltage-activated (LVA) and high voltage-activated (HVA). LVA responds to small changes in resting membrane pot","[66, 1010, 594, 1511]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,9,text,"Ca2+ in the cytoplasm binds to the Ca2+-binding protein, +calmodulin (CaM). CaM can act as a calcium sensor and signal +transducer, binding and activating target proteins that cannot +bind to calcium by ","[614, 121, 1145, 601]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,10,text,The CaM/Cn/NFAT signal pathway mediated by $ Ca^{2+} $ influx is a widely recognized mechanism. It has been confirmed in many works such as external ES mediated by conductive substrates and in-situ E,"[617, 600, 1144, 721]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,11,paragraph_title,Surface receptor redistribution,"[618, 744, 879, 767]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Surface receptor redistribution""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +22,12,text,"Membrane proteins, as signal integrators, can respond to extracellular stimuli and changes in transmembrane potential [270]. The ES-induced cascade may be realized by the redistribution of charged cel","[616, 769, 1144, 912]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,13,text,"MAPK is a highly conserved family of serine/threonine protein kinases that mediate many important physiological activities including proliferation, differentiation, migration, apoptosis, and survival.","[616, 913, 1145, 1101]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,14,text,"In addition to responding to Ca²⁺, GPCR can also directly respond to external stimuli. The signal cascade triggered after receptor activation involves multiple signal pathways. The fibronectin recepto","[616, 1104, 1145, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,15,number,198,"[72, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,0,header,Materials Today • Volume 68 • September 2023,"[82, 61, 421, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +23,1,header,RESEARCH,"[1072, 61, 1154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,2,image,,"[96, 136, 1130, 849]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,3,figure_title,FIG. 9,"[85, 859, 135, 878]",figure_caption,0.92,"[""figure_title label: FIG. 9""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +23,4,figure_title,Summary of the mechanism of cell response induced by electrical stimulation.,"[81, 884, 631, 906]",figure_caption_candidate,0.85,"[""figure_title label: Summary of the mechanism of cell response induced by electri""]",figure_caption,0.85,body_zone,legend_like,none,False,False +23,5,text,"pathway, which has been proven to promote bone formation under pulsed electromagnetic fields [248,271].","[79, 942, 604, 988]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,6,text,"The electrical microenvironment can also regulate the content of PI3K and PTEN through integrins in PI3K/Akt signaling pathway, sequentially regulate the signal transduction of Akt2-IRF5/HIF-1α, and a","[79, 991, 605, 1131]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,7,text,Studies have also found that the expression of cadherin 16 (Cdh16) was up-regulated after MSCs were seeded on BFO $ ^{+} $nanofilm for 3 h [242]. Cdh is a transmembrane protein that can mediate cell a,"[78, 1134, 606, 1348]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,8,paragraph_title,Adenosine triphosphate (ATP),"[79, 1390, 335, 1413]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Adenosine triphosphate (ATP)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +23,9,text,The ATPase on the membrane can absorb energy from ES of specific frequency and amplitude to regulate the activity of membrane proteins. The mitochondrial membrane that receives the electrical signal a,"[77, 1415, 605, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,10,text,"ation process usually requires a large amount of ATP. The work of +ES to drive MSCs' cartilage formation shows that ES can directly +induce MSCs to produce Ca2+/ATP oscillations. The purinergic +receptor","[626, 941, 1156, 1348]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,11,paragraph_title,Reactive oxygen species (ROS),"[630, 1390, 889, 1413]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Reactive oxygen species (ROS)""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +23,12,text,"The production of ROS may be another mechanism by which cells respond to electrical signals. Mitochondria are the main source of endogenous ROS, and a small portion of the electrons leak out from the ","[626, 1415, 1156, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,13,aside_text,RESEARCH: Review,"[1183, 341, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +23,14,number,199,"[1123, 1537, 1154, 1554]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,0,aside_text,RESEARCH: Review,"[25, 341, 42, 482]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +24,1,header,RESEARCH,"[71, 61, 154, 80]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,2,header,Materials Today • Volume 68 • September 2023,"[803, 61, 1142, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +24,3,text,"dria to produce ROS. Too high levels of ROS can cause oxidative damage to DNA, proteins, and lipids, and can even lead to diseases such as diabetes and cancer. But the physiological level of ROS serve","[67, 123, 594, 265]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,4,text,"In the work of exploring the effects of PVDF-TrFE membranes with different piezoelectric properties on the osteogenic differentiation of MSCs, MSCs grown on a membrane with d33 = 10 pC/N have the lowe","[66, 267, 594, 578]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,5,paragraph_title,Conclusions and outlook,"[68, 623, 318, 646]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conclusions and outlook""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +24,6,text,"As an important part of organisms, ENEF plays an indispensable role in regulating growth and development and mediating signal transmission. However, unlike neurons and cardiomyocytes, bone cells canno","[67, 651, 594, 1102]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,7,text,"Although a series of conductive materials have been developed as substrates for delivering electrical signals to cells, they can also provide other biophysical and biochemical cues to achieve synerget","[67, 1103, 595, 1509]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,8,text,"Drug Administration (FDA) has approved a series of bone growth +ES devices since 1979 for the treatment of bone-related diseases +such as nonunion of fractures, congenital false joints, spinal +fusion, a","[614, 122, 1145, 673]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,9,text,"In this case, the importance of self-powered ES devices has been highlighted. Piezoelectric materials do not require the implantation of electrodes and wires, which is a relatively safer choice. Altho","[614, 674, 1147, 1510]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,10,number,200,"[71, 1536, 103, 1553]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,0,header,Materials Today • Volume 68 • September 2023,"[81, 61, 421, 81]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +25,1,header,RESEARCH,"[1071, 62, 1154, 79]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,2,text,"ideal TENG for bone regeneration should be completely sealed, with no exposed wires, and only a multifunctional conductive interface with nano-topography that contact cells is exposed. Furthermore, th","[78, 122, 606, 360]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,3,text,"Compared with other synergistic therapies, ES treatment has gained a head start with years of clinical experience. However, expensive treatment costs and long treatment cycles still limit its applicat","[78, 362, 606, 626]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,4,paragraph_title,Data availability,"[81, 652, 247, 675]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data availability""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +25,5,text,Data will be made available on request.,"[104, 678, 406, 699]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,6,paragraph_title,Declaration of Competing Interest,"[80, 723, 420, 745]",backmatter_heading,0.5,"[""backmatter boundary candidate: Declaration of Competing Interest""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +25,7,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[79, 749, 605, 813]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,8,paragraph_title,Acknowledgements,"[81, 836, 278, 858]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +25,9,text,"This work is supported by the Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award (Grant No. 113548; to W. T.), Harvard Medical School/Brigham and Women's Hospital D","[77, 863, 607, 1198]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,10,paragraph_title,References,"[80, 1218, 169, 1238]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +25,11,reference_content,"[1] X. Zhang et al., Matter 4 (9) (2021) 2727.","[95, 1245, 381, 1261]",reference_item,0.85,"[""reference content label: [1] X. Zhang et al., Matter 4 (9) (2021) 2727.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +25,12,reference_content,"[2] G.L. Koons et al., Nat. Rev. Mater. 5 (8) (2020) 584.","[95, 1263, 443, 1281]",reference_item,0.85,"[""reference content label: [2] G.L. Koons et al., Nat. Rev. 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Qian et al., Small 16 (32) (2020) 2000796.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +27,44,reference_content,"[275] J Zhou et al., Exploration 1 (2021) 20210011.","[633, 466, 959, 483]",reference_item,0.85,"[""reference content label: [275] J Zhou et al., Exploration 1 (2021) 20210011.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +27,45,reference_content,"[276] X Wan et al., Exploration 2 (2022) 20210029.","[633, 484, 959, 500]",reference_item,0.85,"[""reference content label: [276] X Wan et al., Exploration 2 (2022) 20210029.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +27,46,reference_content,"[277] Y Bian et al., Exploration 3 (2023) 20210105.","[633, 502, 957, 519]",reference_item,0.85,"[""reference content label: [277] Y Bian et al., Exploration 3 (2023) 20210105.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +27,47,reference_content,"[278] Y Zhang et al., Exploration 1 (2021) 90.","[633, 522, 922, 538]",reference_item,0.85,"[""reference content label: [278] Y Zhang et al., Exploration 1 (2021) 90.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +27,48,reference_content,"[279] S Li et al., Exploration 2 (2022) 20210223.","[633, 541, 939, 557]",reference_item,0.85,"[""reference content label: [279] S Li et al., Exploration 2 (2022) 20210223.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +27,49,number,203,"[1122, 1537, 1153, 1554]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +27,50,aside_text,RESEARCH: Review,"[1183, 343, 1199, 481]",unknown_structural,0.2,"[""unrecognized label 'aside_text'""]",unknown_structural,0.2,,unknown_like,short_fragment,False,True diff --git a/tests/fixtures/ocr_real_papers/KNEBDHHT/block_trace.csv b/tests/fixtures/ocr_real_papers/KNEBDHHT/block_trace.csv new file mode 100644 index 00000000..98b1f8f7 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/KNEBDHHT/block_trace.csv @@ -0,0 +1,244 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[84, 124, 205, 231]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,1,header,Materials and Design 195 (2020) 109025,"[484, 71, 724, 92]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,header,ELSEVIER,"[85, 236, 206, 261]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,3,header,Contents lists available at ScienceDirect,"[461, 123, 753, 147]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,4,header,Materials and Design,"[471, 166, 742, 201]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,5,header,journal homepage: www.elsevier.com/locate/matdes,"[364, 235, 848, 259]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,6,header_image,,"[1010, 112, 1121, 247]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True +1,7,doc_title,Melt electrowriting onto anatomically relevant biodegradable substrates: Resurfacing a diarthrodial joint,"[78, 330, 958, 399]",paper_title,0.6,"[""page-1 frontmatter title guard: Melt electrowriting onto anatomically relevant biodegradable""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,8,image,,"[1010, 325, 1067, 382]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,9,text,"Quentin C. Peiffer $ ^{a,b,1} $, Mylène de Ruijter $ ^{a,b,1} $, Joost van Duijn $ ^{a,b} $, Denis Crottet $ ^{c} $, Ernst Dominic $ ^{c} $, Jos Malda $ ^{a,b,d} $, Miguel Castilho $ ^{a,b,e,*} $","[79, 413, 994, 468]",authors,0.8,"[""page-1 zone author_zone: Quentin C. Peiffer $ ^{a,b,1} $, Myl\u00e8ne de Ruijter $ ^{a,b,1""]",authors,0.8,body_zone,reference_like,citation_line,True,True +1,10,text," $ ^{a} $ Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, GA, Utrecht, the Netherlands","[79, 478, 706, 497]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $ Department of Orthopaedics, University Medical Cent""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,11,text,"Regenerative Medicine Center Utrecht, Utrecht, the Netherlands","[81, 496, 444, 514]",affiliation,0.8,"[""page-1 zone affiliation_zone: Regenerative Medicine Center Utrecht, Utrecht, the Netherlan""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,12,text," $ ^{c} $ RegenHU Ltd, Villaz-St-Pierre, Switzerland","[81, 513, 327, 530]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{c} $ RegenHU Ltd, Villaz-St-Pierre, Switzerland""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,13,text," $ ^{d} $ Department of Clinical Sciences, Faculty of Veterinary Sciences, Utrecht University, Utrecht, the Netherlands","[80, 529, 680, 547]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{d} $ Department of Clinical Sciences, Faculty of Veterin""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,14,text," $ ^{e} $ Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands","[80, 546, 812, 566]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{e} $ Orthopaedic Biomechanics, Department of Biomedical ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,15,paragraph_title,HIGHLIGHTS,"[81, 602, 229, 622]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: HIGHLIGHTS""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True +1,16,text,• Microfibre patterning onto an anatomical relevant structure and clinically relevant materials is demonstrated.,"[82, 646, 354, 703]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,17,text,• Accurate microfibre patterning is demonstrated on both electrically conductive and non-conductive materials.,"[82, 704, 355, 761]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,18,text,"• Fabrication of a microfibre-reinforced, cell-laden hydrogel that resurfaces a human biological joint replica is shown","[81, 761, 356, 821]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,19,paragraph_title,ARTICLE INFO,"[80, 902, 278, 922]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: ARTICLE INFO""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True +1,20,text,"Article history: +Received 30 May 2020 +Received in revised form 30 July 2020 +Accepted 30 July 2020 +Available online 4 August 2020","[81, 941, 304, 1028]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Article history:\nReceived 30 May 2020\nReceived in revised fo""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,21,text,"Keywords: +Fibre-reinforced hydrogels +Anatomical surfaces +Electrostatics +Electrospinning +Osteochondral defects +Biofabrication","[81, 1045, 239, 1167]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords:\nFibre-reinforced hydrogels\nAnatomical surfaces\nEle""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,22,paragraph_title,GRAPHICAL ABSTRACT,"[410, 603, 674, 622]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: GRAPHICAL ABSTRACT""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,False,True +1,23,image,,"[412, 718, 562, 840]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,24,image,,"[622, 712, 791, 862]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,25,image,,"[836, 711, 1053, 853]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,26,paragraph_title,A B S T R A C T,"[410, 902, 549, 922]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: A B S T R A C T""]",section_heading,0.5,body_zone,body_like,short_fragment,True,True +1,27,abstract,Three-dimensional printed hydrogel constructs with well-organized melt electrowritten (MEW) fibre-reinforcing scaffolds have been demonstrated as a promising regenerative approach to treat small carti,"[407, 940, 1128, 1227]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,28,text,© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/),"[429, 1227, 1126, 1261]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2020 The Author(s). Published by Elsevier Ltd. This is an ""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False +1,29,paragraph_title,1. Introduction,"[618, 1316, 737, 1337]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +1,30,footnote,"* Corresponding author at: Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, GA, Utrecht, the Netherlands.","[82, 1350, 590, 1385]",footnote,0.7,"[""footnote label: * Corresponding author at: Department of Orthopaedics, Unive""]",footnote,0.7,body_zone,body_like,none,True,True +1,31,text,Articular cartilage in diarthrodial joints functions as a load-bearing tissue with a nearly frictionless surface. This unique characteristic is attributed to the composition of cartilage tissue where ,"[615, 1358, 1129, 1424]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,32,footnote,"E-mail address: M.DiasCastilho@umcutrecht.nl (M. Castilho). + $ ^{1} $Shared authorship.","[81, 1384, 454, 1423]",footnote,0.7,"[""footnote label: E-mail address: M.DiasCastilho@umcutrecht.nl (M. Castilho).\n""]",footnote,0.7,body_zone,body_like,none,True,True +1,33,footer,"https://doi.org/10.1016/j.matdes.2020.109025 + +0264-1275/© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/","[81, 1456, 1001, 1495]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,number,2,"[65, 74, 77, 89]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421, 72, 752, 91]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +2,2,text,"(structural) components, type II collagen fibrils and glycosaminoglycans (GAGs), as well as cells, are hierarchically distributed throughout the tissue [1–3]. Damage to articular cartilage can cause p","[61, 111, 573, 404]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,Regenerative approaches based on biofabrication [10] technologies are a potential alternative to repair damaged articular cartilage tissue [11]. Advances in (micro) fibre formation and deposition tech,"[61, 404, 574, 823]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"It is known that the electrical field (EF), and its resulting electrical force, the main fibre pulling force in the MEW process, is affected by the collector design in both shape, dimension [24], and ","[61, 825, 574, 1345]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Therefore, in this study, we investigate how to translate the fabrication of fibre reinforced structures from flat to more anatomically relevant, non-flat surfaces with the convergence of MEW and extr","[60, 1346, 574, 1453]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,text,"domes) and biomaterials, i.e. bioceramics, magnesium phosphate ce- +ment (MgP); thermoplastics, polycaprolactone (PCL); and hydrogels, +gelatin methacryloyl (gelMA), is studied (Fig. 1). Through computa","[596, 111, 1110, 301]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,7,paragraph_title,2. Materials and methods 2.1. Materials,"[598, 320, 796, 383]",paper_title,0.6,"[""page-1 frontmatter title guard: 2. Materials and methods 2.1. Materials""]",paper_title,0.6,frontmatter_side_zone,support_like,heading_numbered,True,True +2,8,footer,,"[599, 362, 700, 383]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +2,9,text,"Gelatin methacryloyl (gelMA) was synthesized as previously described [36]. Briefly, gelatin (type A, derived from porcine skin, 175 Bloom, Sigma Aldrich) was dissolved at 10% w/v in phosphate-buffered","[596, 404, 1111, 888]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,10,paragraph_title,2.2. Impedance spectroscopy measurements,"[598, 907, 904, 929]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Impedance spectroscopy measurements""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +2,11,text,"Dielectric properties of substrate materials were measured with an impedance/gain-phase analyser (1260 Impedance Analyser, Solartron Analytical) with a dielectric interface (1296A Dielectric Interface","[596, 949, 1110, 1181]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,12,display_formula, $$ \varepsilon_{r}=\frac{C}{C_{0}} $$ ,"[603, 1192, 665, 1234]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +2,13,formula_number,(1),"[1083, 1203, 1107, 1224]",non_body_insert,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,False +2,14,text,"where $ C_{0} $ is the capacity of the empty capacitor. In addition, electrical conductivity ( $ \sigma $) in siemens per metre was obtained indirectly by determining first the material resistance (R","[595, 1250, 1109, 1337]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,15,display_formula, $$ \sigma=\frac{l}{RA} $$ ,"[598, 1349, 659, 1389]",non_body_insert,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,False +2,16,formula_number,(2),"[1083, 1360, 1107, 1380]",non_body_insert,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,False +2,17,text,where l terms represent length and A the cross-sectional area of the measured material specimen.,"[596, 1404, 1109, 1449]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,0,header,Q.C. Peiffer et al / Materials and Design 195 (2020) 109025,"[439, 72, 769, 91]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,1,number,3,"[1113, 73, 1126, 90]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,image,,"[182, 106, 1023, 244]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,3,image,,"[180, 241, 1026, 335]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,4,figure_title,B.,"[187, 350, 203, 370]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,5,image,,"[186, 347, 1013, 593]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +3,6,figure_title,C.,"[584, 350, 604, 370]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +3,7,figure_title,Fig. 1. Deposition of melt electrowritten (MEW) fibres on clinically relevant shapes and materials. A) Schematic representation of the different collecting geometries ranging from flat (with a thickne,"[79, 619, 1125, 691]",figure_caption,0.92,"[""figure_title label: Fig. 1. Deposition of melt electrowritten (MEW) fibres on cl""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +3,8,paragraph_title,2.3. Surface roughness measurements,"[81, 735, 342, 757]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Surface roughness measurements""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,9,text,"Surface roughness of substrate materials was measured using a surface roughness tester (SJ-400, Mitutoyo Corp.) as detailed in Supplementary Methods.","[80, 777, 590, 841]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,paragraph_title,2.4. Melt electrowriting (MEW),"[81, 876, 301, 898]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Melt electrowriting (MEW)""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,11,text,"MEW was performed with polycaprolactone (PCL, Purasorb PC12, Corbion) molten in a metallic cartridge at 80 °C with an air pressure of 110–125 kPa, 24G nozzle, voltage of 7–11 kV (3D Discovery Evolutio","[79, 917, 592, 1109]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,12,paragraph_title,2.5. Fibre evaluation,"[81, 1142, 226, 1163]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Fibre evaluation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,13,text,"Fibre morphology and fibre stacking was evaluated by scanning electronic microscopy (SEM) (Phenom Pro desktop, ThermoFischer Scientific) (Supplementary Fig. 2A). Samples were coated with 6 nm gold usi","[78, 1183, 591, 1312]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,14,paragraph_title,2.6. Printing accuracy quantification,"[81, 1346, 333, 1368]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Printing accuracy quantification""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,15,text,Fibre scaffolds were imaged with an upright microscope (Olympus BX430) and subsequently processed with Fiji (version 2.0.0-rc-54/1.51 h). A selection of pores in the central region of the scaffold wer,"[79, 1388, 590, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,16,paragraph_title,2.7. Finite element analysis,"[617, 735, 808, 756]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Finite element analysis""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,17,text,"Numerical simulation of the electric field strength and distribution were performed (COMSOL Multiphysics Simulation Software, Version 5.1 COMSOL Inc.). The MEW printhead and collecting substrate geome","[614, 777, 1129, 1093]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,18,paragraph_title,2.8. Fabrication and matrix formation of clinically relevant surfaces,"[616, 1114, 1080, 1136]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Fabrication and matrix formation of clinically relevant""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,19,text,"A polycaprolactone (PCL) dome structure was resurfaced with MEW fibres and gelatin methacryloyl (gelMA) hydrogel, encapsulated with articular cartilage progenitor cells (ACPCs). A screw driven extrusi","[614, 1156, 1128, 1388]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,20,paragraph_title,2.9. Cell culture,"[616, 1409, 730, 1430]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Cell culture""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +3,21,text,Equine derived articular cartilage-resident progenitor cells (ACPCs) were isolated from the metacarpophalangeal joints of skeletally mature,"[615, 1451, 1126, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,4,"[64, 74, 77, 88]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421, 72, 752, 91]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +4,2,text,equine donors and expanded as previously described [38]. These donors have been donated to science by their owners and procedures were followed according to the guidelines of the Ethical and Animal We,"[61, 112, 574, 426]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,2.10. In vitro evaluation of (bio) fabricated implants,"[62, 446, 425, 468]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. In vitro evaluation of (bio) fabricated implants""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,4,text,"During culture, metabolic activity was measured using a resazurin assay (Sigma Aldrich) at day 1, 7, 14, 28. After 28 days, matrix formation was quantified by biochemical assessment of GAG (dimethylme","[62, 488, 574, 720]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,paragraph_title,2.11. Mechanical analysis of fibre reinforced gelMA scaffolds,"[62, 739, 478, 761]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.11. Mechanical analysis of fibre reinforced gelMA scaffold""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,6,text,"Uniaxial compression tests were performed on a universal testing machine (Zwick Z010, Germany) equipped with a 20 N load cell. Tests were conducted at a rate of 1 mm/min at room temperature, with all ","[61, 780, 574, 950]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,paragraph_title,2.12. Statistical analysis,"[63, 969, 232, 990]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.12. Statistical analysis""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,8,text,"Data is represented as mean ± standard deviation. For surface roughness measurements, impedance spectroscopy, fibre diameter measurements, scaffold thickness, pore ratio, and in vitro studies, at leas","[61, 1010, 573, 1286]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,9,paragraph_title,3. Results 3.1. Material properties: Surface roughness and electrical conductive properties,"[62, 1304, 572, 1389]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results 3.1. Material properties: Surface roughness and e""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,10,footer,,"[62, 1346, 572, 1389]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +4,11,text,Magnesium phosphate (MgP) and gelMA substrates presented higher surface roughness values (R_a and R_q between 3.61 and 5.21 μm) than PCL and Aluminium substrates (R_a and R_q between 0.07 and 0.32 μm),"[61, 1409, 573, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,12,text,"confirmed the electrical conductivity and relative permittivity of PCL, +MgP, gelMA, and aluminium (Al) collecting substrates of 1 and 4 mm +(Table 1). PCL and MgP behaved as non-conductive materials wit","[596, 110, 1110, 260]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,13,paragraph_title,3.2. Effect of collecting material conductivity on fibre deposition,"[598, 280, 1038, 302]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Effect of collecting material conductivity on fibre dep""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,14,text,"The effect of the conductivity of the collecting materials on fibre deposition was studied using substrates with thicknesses of 1 and 4 mm (Fig. 2A, B). A significant smaller fibre diameter was observ","[596, 322, 1111, 740]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,15,text,"Scaffolds fabricated onto non-conductive materials (PCL, MgP) were ~50 $ \mu $m less high as compared to scaffolds fabricated onto conductive materials (gelMA, aluminium) (Fig. 2G, supplementary Fig.","[596, 740, 1110, 952]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,16,paragraph_title,"3.3. Effect of collector geometry on fibre deposition: non-flat, wedge and curved substrates","[597, 972, 1109, 1014]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Effect of collector geometry on fibre deposition: non-f""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,17,text,"Printing onto a 45° wedge substrates showed similar trends as printing onto dome-structures. In general, printing on wedge-shaped collecting materials without z-correction in the printing trajectory (","[596, 1034, 1110, 1245]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,18,figure_title,"Table 1 +Relative permittivity $ \varepsilon_{r} $ and electrical conductivity $ \sigma $ of investigated materials.","[597, 1289, 1067, 1327]",table_caption,0.9,"[""table prefix matched: Table 1\nRelative permittivity $ \\varepsilon_{r} $ and elect""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,19,table,"
Substrate biomaterialRelative permittivity ( $ \varepsilon_{r} $, at 1 Hz)Electrical conductivity ( $ \sigma $, S m $ ^{-1} $)
Polycaprolactone (PCL)<","[602, 1330, 1104, 1487]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +5,0,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[438, 72, 769, 91]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +5,1,number,5,"[1113, 73, 1126, 90]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,figure_title,A.,"[158, 104, 185, 131]",figure_inner_text,0.9,"[""panel label / figure inner text: A.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,3,image,,"[158, 106, 601, 250]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,4,figure_title,B.,"[603, 106, 625, 130]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,5,image,,"[609, 102, 990, 245]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,6,figure_title,C.,"[154, 254, 182, 283]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,7,chart,,"[152, 292, 575, 591]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,8,figure_title,D.,"[603, 254, 632, 281]",figure_inner_text,0.9,"[""panel label / figure inner text: D.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,9,chart,,"[613, 282, 1039, 593]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,10,figure_title,E.,"[157, 596, 182, 624]",figure_inner_text,0.9,"[""panel label / figure inner text: E.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,11,image,,"[145, 629, 595, 742]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,12,figure_title,F.,"[618, 597, 640, 623]",figure_inner_text,0.9,"[""panel label / figure inner text: F.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,13,image,,"[147, 766, 594, 900]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,14,image,,"[613, 615, 1059, 889]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,15,figure_title,G.,"[154, 912, 184, 939]",figure_inner_text,0.9,"[""panel label / figure inner text: G.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +5,16,chart,,"[152, 939, 580, 1215]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,17,chart,,"[614, 911, 1026, 1218]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +5,18,figure_title,"Fig. 2. Fibre collection on flat-shaped collecting materials (PCL, MgP, gelMA, and Al). A, B) collecting materials of 1 mm and 4 mm high were investigated. C) Effect of collector velocity on fibre dia","[79, 1240, 1125, 1329]",figure_caption,0.92,"[""figure_title label: Fig. 2. Fibre collection on flat-shaped collecting materials""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +5,19,text,"These observations are slightly more pronounced for less conductive materials (PCL and MgP). Scaffolds fabricated (using z-trajectory correction) onto non-conductive wedges (PCL, MgP) were 100 to 200 ","[79, 1371, 591, 1479]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,20,text,"MgP wedges featured two-fold lower pore ratio than scaffolds fabri- +cated onto the gelMA wedge.","[614, 1372, 1125, 1414]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,21,text,"Z-correction in the printhead trajectory also improved the accuracy of fibre deposition when printing onto dome-structures (Fig. 3A, B). Computational simulation confirmed that the EF strength was con","[615, 1415, 1127, 1478]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,0,number,6,"[64, 74, 78, 90]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421, 72, 752, 91]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +6,2,figure_title,A.,"[146, 107, 169, 131]",figure_inner_text,0.9,"[""panel label / figure inner text: A.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,3,figure_title,B.,"[639, 109, 658, 130]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,4,image,,"[142, 113, 999, 369]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,5,figure_title,C.,"[134, 387, 157, 410]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,6,figure_title,PO,"[279, 390, 308, 413]",figure_caption_candidate,0.85,"[""figure_title label: PO""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +6,7,image,,"[132, 388, 1040, 665]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,8,chart,,"[133, 675, 572, 960]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,9,figure_title,E.,"[580, 675, 601, 699]",figure_inner_text,0.9,"[""panel label / figure inner text: E.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +6,10,chart,,"[590, 667, 1028, 959]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +6,11,figure_title,"Fig. 3. Fibre collection on curved collecting materials (PCL, MgP, gelMA, and Al). A) Schematic representation of the evaluated printhead trajectories with and without z-correction. B) Representative ","[63, 983, 1107, 1072]",figure_caption,0.92,"[""figure_title label: Fig. 3. Fibre collection on curved collecting materials (PCL""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,12,text,"and normal to the curved surface when printing with z-correction in the printhead trajectory (Fig. 3C). Although scaffold thickness was relatively unaffected by the collecting material used, scaffold ","[61, 1115, 574, 1327]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,13,paragraph_title,3.4. Resurfacing the entire joint surface – Simple convex surfaces,"[63, 1346, 508, 1368]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Resurfacing the entire joint surface \u2013 Simple convex su""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,14,text,"A PCL scaffold, approximating the native curvature of an average human femur, was successfully resurfaced with a boxed-microfibre architecture and filled with a cell-laden gelMA hydrogel (Fig. 4A). Th","[61, 1388, 574, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,15,text,"in the compressive modulus as compared to hydrogel only and scaffold +only groups (Supplementary Fig. 5). During the 28 days of culture, the +fibre reinforced hydrogel on top of the femur structure retai","[595, 1114, 1111, 1306]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,16,paragraph_title,4. Discussion,"[598, 1325, 703, 1346]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,17,text,"This study demonstrates the challenges of translating the fabrication of microfibre reinforcing scaffolding structures from flat to curved, anatomically relevant geometries and clinically relevant mat","[596, 1367, 1110, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,0,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[438, 72, 769, 91]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +7,1,number,7,"[1113, 73, 1126, 89]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,figure_title,A.,"[93, 108, 115, 129]",figure_inner_text,0.9,"[""panel label / figure inner text: A.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,3,figure_title,Chondrogenic part,"[713, 107, 847, 128]",figure_caption_candidate,0.85,"[""figure_title label: Chondrogenic part""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +7,4,image,,"[99, 125, 1093, 330]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,5,figure_title,B.,"[95, 331, 113, 351]",figure_inner_text,0.9,"[""panel label / figure inner text: B.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,6,image,,"[125, 341, 1101, 546]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,7,figure_title,C.,"[92, 549, 115, 572]",figure_inner_text,0.9,"[""panel label / figure inner text: C.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,8,figure_title,D.,"[458, 549, 480, 572]",figure_inner_text,0.9,"[""panel label / figure inner text: D.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,9,chart,,"[117, 562, 426, 798]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,10,figure_title,E.,"[94, 791, 114, 814]",figure_inner_text,0.9,"[""panel label / figure inner text: E.""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +7,11,image,,"[468, 554, 1106, 1016]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,12,chart,,"[107, 811, 420, 1023]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +7,13,figure_title,Fig. 4. Resurfacing a fully resorbable PCL mimicking contour of a human femoral condyle surface and cartilage-like tissue formation after 28 days of in vitro culture. A) Macroscopic cross section of M,"[79, 1045, 1125, 1116]",figure_caption,0.92,"[""figure_title label: Fig. 4. Resurfacing a fully resorbable PCL mimicking contour""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,14,text,"relevant material and anatomically relevant shapes was achieved. Furthermore, a converged printed, resurfaced human condyle-shaped construct was fabricated and supported cartilage-tissue formation aft","[79, 1160, 591, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,15,text,"It was shown that MEW fibre diameters are strongly affected by the materials they are printed on. Printing on conductive materials (gelMA, aluminium) resulted in larger fibre diameters as compared to ","[79, 1244, 591, 1455]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,16,text,"induced jet-lag. Interestingly, fibre diameter was not affected by the +thickness of the collecting materials used, which confirmed that electri- +cal conductive properties are not significantly affected b","[613, 1159, 1128, 1456]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,0,number,8,"[65, 74, 78, 89]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,Q.C. Peiffer et al. / Materials and Design 195 (2020) 109025,"[421, 72, 752, 91]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +8,2,text,only small differences in the EF strength magnitude were determined when using PCL and MgP as collecting materials in comparison to the more conductive collecting materials.,"[61, 112, 573, 173]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,3,text,"Interestingly, accurate fibre deposition on non-flat, i.e. wedge- and curve-shaped, collecting materials was significantly improved when the distance between the printhead and the collecting substrate","[61, 175, 574, 445]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,text,"Although we have shown that accurate deposition of MEW fibres is possible on different collecting materials and on anatomically relevant geometries, some deposition inaccuracies were still observed. I","[61, 446, 574, 844]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,5,text,"As a potential application to treat full-thickness cartilage or osteochondral defects, we demonstrated the fabrication of structures with a fibre-reinforced osteochondral construct that anatomically r","[61, 844, 574, 1307]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +8,6,paragraph_title,5. Conclusion,"[63, 1325, 171, 1346]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusion""]",section_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +8,7,text,"on less conductive materials, including bioceramics and thermoplasts. Accurate fibre deposition on non-flat geometries (wedge- and curved-shape structures) was shown to be successful, yet, maintaining","[596, 111, 1110, 363]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,text,"Taken together, this study demonstrates the printing of well-organized microfibre scaffolds on clinically relevant collecting materials with non-flat geometries. The electrical properties of the subst","[61, 1367, 574, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,body_like,none,True,True +8,9,text,"Supplementary data to this article can be found online at https://doi. +org/10.1016/j.matdes.2020.109025.","[596, 364, 1108, 405]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,10,paragraph_title,Funding sources,"[599, 431, 730, 452]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Funding sources""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,11,text,"This research was supported by EU funded—E11312 BioArchitect project together with regenHU, the Dutch Arthritis Foundation (LLP-12), and the European Research Council (ERC) consolidator grant 3D-JOINT","[596, 472, 1110, 641]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,12,paragraph_title,Authors contributions,"[598, 666, 773, 687]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Authors contributions""]",subsection_heading,0.6,body_zone,body_like,none,True,True +8,13,text,"Conceived and designed the experiment: MC, MdR, QCP, JvD. Collected the data: MdR, QCP.","[622, 708, 1064, 749]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,14,text,"Contributed data or analysis tools: MdR, QCP, MC, JvD, ED, DC. +Performed analysis: MdR, QCP, MC, ED, DC.","[622, 751, 1071, 798]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,15,text,"Wrote the manuscript: MC, MdR, QCP, JM.","[623, 792, 931, 814]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,16,paragraph_title,Declaration of Competing Interest,"[598, 838, 862, 859]",backmatter_heading,0.5,"[""backmatter boundary candidate: Declaration of Competing Interest""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True +8,17,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[597, 879, 1109, 945]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,18,paragraph_title,Acknowledgments,"[599, 964, 746, 985]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +8,19,text,"The authors gratefully thank Jacopo Bani, Alexandre Ribeiro and Michael Kuster for their help with the experimental part of this manuscript. In addition, the authors are very grateful to Marco Viveen ","[596, 1004, 1111, 1236]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,20,paragraph_title,References,"[600, 1257, 688, 1278]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +8,21,reference_content,"[1] J Alice S.F., B. Asheesh, A.R. Scoot, The Basic Science of Articular Cartilage: Sports Health, 1, 2009 461–468.","[607, 1293, 1108, 1325]",reference_item,0.85,"[""reference content label: [1] J Alice S.F., B. Asheesh, A.R. Scoot, The Basic Science ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +8,22,reference_content,"[2] I.A.D. Mancini, L. Rieppo, B. Pouran, I.O. Afara, F.M.S. 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Moutos, et al., Anatomically shaped tissue-enginee""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True diff --git a/tests/fixtures/ocr_real_papers/KZP6FB4Y/block_trace.csv b/tests/fixtures/ocr_real_papers/KZP6FB4Y/block_trace.csv new file mode 100644 index 00000000..b4ac4708 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/KZP6FB4Y/block_trace.csv @@ -0,0 +1,745 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header_image,,"[73, 121, 193, 228]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,1,header,Biomaterials 320 (2025) 123288,"[486, 68, 702, 89]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False +1,2,header,ELSEVIER,"[73, 233, 194, 258]",noise,0.9,"[""header 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med""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,8,image,,"[1001, 297, 1059, 353]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,9,text,"Shuncheng Yao $ ^{a,b,1} $, Xi Cui $ ^{b,d,1} $, Chao Zhang $ ^{d,*} $, Wenguo Cui $ ^{a,**} $, Zhou Li $ ^{b,c,***} $ $ ^{ID} $","[70, 382, 695, 435]",authors,0.8,"[""page-1 zone author_zone: Shuncheng Yao $ ^{a,b,1} $, Xi Cui $ ^{b,d,1} $, Chao Zhang ""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,10,text," $ ^{a} $ Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruiin Hospital, Shanghai Jia","[71, 449, 969, 478]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $ Department of Orthopaedics, Shanghai Key Laboratory""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,11,text,"Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","[71, 466, 588, 486]",affiliation,0.8,"[""page-1 zone affiliation_zone: Ruijin Hospital, Shanghai Jiao Tong University School of Med""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +1,12,text," $ ^{b} $ Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China","[70, 484, 649, 502]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{b} $ Beijing Institute of Nanoenergy and Nanosystems, Ch""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,13,text," $ ^{c} $ School of Nanoscience and Engineering, Chinese Academy of Sciences, Beijing, 100049, China","[71, 503, 597, 519]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{c} $ School of Nanoscience and Engineering, Chinese Acad""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,14,text," $ ^{d} $ School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, China","[72, 519, 663, 537]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{d} $ School of Biomedical Engineering, Shenzhen Campus o""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +1,15,paragraph_title,ARTICLE INFO,"[71, 584, 234, 602]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: ARTICLE INFO""]",authors,0.6,body_zone,body_like,short_fragment,False,True +1,16,text,"Keywords: +Force-electric conversion +Piezoelectric +Triboelectric +Electroactive +Regenerative medicine","[71, 621, 220, 726]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords:\nForce-electric conversion\nPiezoelectric\nTriboelect""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,17,paragraph_title,A B S T R A C T,"[400, 583, 522, 602]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: A B S T R A C T""]",section_heading,0.5,body_zone,body_like,short_fragment,True,True +1,18,abstract,"There is a growing recognition that force-electric conversion biomaterials and devices can convert mechanical energy into electrical energy without an external power source, thus potentially revolutio","[397, 622, 1120, 873]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +1,19,paragraph_title,1. Introduction,"[72, 931, 198, 951]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +1,20,text,"As human society continues to develop, human concern for their own health is increasing. However, the rapid ageing of the population, unhealthy diets and the occurrence of accidents have placed a heav","[69, 973, 582, 1226]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,21,text,"medicine. The generation of bioelectricity is related to the segregation of +biofilm formation as well as the distribution and flow of ions on both +sides of these membranes, and the resulting bioelectr","[606, 931, 1119, 1226]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,22,footnote,This article is part of a special issue entitled: Regenerative Bioelectronics published in Biomaterials.,"[77, 1264, 728, 1283]",footnote,0.7,"[""footnote label: This article is part of a special issue entitled: Regenerati""]",footnote,0.7,body_zone,body_like,none,True,True +1,23,footnote,* Corresponding author.,"[80, 1285, 249, 1304]",footnote,0.7,"[""footnote label: * Corresponding author.""]",footnote,0.7,body_zone,body_like,none,True,True +1,24,footnote,*** Corresponding author.,"[81, 1304, 254, 1322]",footnote,0.7,"[""footnote label: *** Corresponding author.""]",footnote,0.7,body_zone,body_like,none,True,True +1,25,footnote,"*** Corresponding author. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.","[81, 1323, 934, 1347]",footnote,0.7,"[""footnote label: *** Corresponding author. Beijing Institute of Nanoenergy an""]",footnote,0.7,body_zone,body_like,none,True,True +1,26,footnote,"E-mail addresses: wgcui@sjtu.edu.cn (C. Zhang), zhchao9@mail.sysu.edu.cn (W. Cui), zli@binn.cas.cn (Z. Li).","[82, 1337, 807, 1361]",footnote,0.7,"[""footnote label: E-mail addresses: wgcui@sjtu.edu.cn (C. Zhang), zhchao9@mail""]",footnote,0.7,body_zone,body_like,none,True,True +1,27,footnote, $ ^{1} $ These authors contributed equally to this work.,"[82, 1361, 411, 1380]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: $ ^{1} $ These authors contributed equally to this work.""]",frontmatter_noise,0.8,body_zone,body_like,affiliation_marker,False,False +1,28,footer,"https://doi.org/10.1016/j.biomaterials.2025.123288 + +Received 13 December 2024; Received in revised form 2 March 2025; Accepted 23 March 2025 + +Available online 24 March 2025 + +0142-9612/© 2025 Elsevier ","[70, 1399, 939, 1470]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +2,0,header,S. Yao et al.,"[71, 70, 145, 88]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,Biomaterials 320 (2025) 123288,"[932, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False +2,2,text,"infections, which limit the further development of electrical stimulation in the field of regenerative medicine.","[68, 107, 581, 149]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,3,text,"The human body generates a large amount of biomechanical energy during physical activity, cardiopulmonary exercise, and blood circulation. In addition, the introduction of external stimuli such as ult","[68, 148, 583, 739]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"the implantable microsystems based on TENG to drive the long-term +operation of implantable medical devices in vivo [29]. However, the +weak and uncertain nature of the ambient mechanical forces results","[606, 107, 1121, 273]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,This review paper aims to overview various applications of force-electric biomaterials and devices based on piezoelectric and triboelectric effects in the field of regenerative medicine (Fig. 1). In o,"[605, 273, 1122, 737]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,image,,"[251, 774, 934, 1443]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,7,figure_title,Fig. 1. Force-electric biomaterials and devices for regenerative medicine under different force-driven modes.,"[237, 1468, 950, 1489]",figure_caption,0.92,"[""figure_title label: Fig. 1. Force-electric biomaterials and devices for regenera""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +2,8,number,2,"[589, 1513, 603, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,0,header,S. Yao et al.,"[71, 70, 145, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +3,2,text,"of diseases. Finally, challenges and opportunities in the application of force-electric biomaterials and devices in the field of regenerative medicine are overviewed.","[68, 106, 582, 170]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,paragraph_title,2. Piezoelectric biomaterials based on force-electric conversion,"[70, 190, 568, 210]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Piezoelectric biomaterials based on force-electric conver""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +3,4,text,"In 1880, the Curie brothers revealed the piezoelectric effect in piezoelectric materials for the first time in their published paper [30], which laid the fundamental working principle of piezoelectric","[67, 232, 583, 589]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,"direction, this design mode is referred to as the d33 mode; if the potential +is perpendicular to the direction of applied stress/strain (i.e., the 1-di­ +rection), it is termed the d31 mode. Additional","[606, 106, 1120, 336]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"Piezoelectric materials are a direct manifestation of the force-electric conversion effect and are crucial components in many modern devices, such as sonar [33], medical US [34], sensors, actuators [3","[606, 337, 1121, 589]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,table,"
i)ii)
TypeApplicationForce-driven modeElectrical propertiesStimulation timeRef.
Piezoelectric biomaterialsRe","[74, 146, 1117, 512]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +20,4,text,"recovery and regulation of organ functions such as the brain, heart, eyes, and muscles; and thirdly, electrical stimulation therapy for specific diseases, utilizing electric field effects to achieve p","[70, 542, 582, 607]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,5,text,"electric field-catalyzed therapy, and electrical stimulation to eliminate +diseased cells, thus providing new methods and strategies for tissue +function recovery and regeneration.","[607, 542, 1120, 606]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,6,figure_title,Tissue regeneration,"[194, 664, 413, 691]",figure_caption_candidate,0.85,"[""figure_title label: Tissue regeneration""]",figure_caption,0.85,body_zone,unknown_like,short_fragment,False,False +20,7,image,,"[155, 709, 446, 840]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,8,image,,"[156, 846, 448, 952]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,9,image,,"[157, 956, 447, 1039]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,10,image,,"[155, 1045, 449, 1274]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,11,image,,"[455, 653, 739, 1272]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,12,image,,"[741, 709, 1033, 878]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,13,figure_title,Functional regulation,"[766, 664, 1007, 692]",figure_caption,0.85,"[""figure_title label: Functional regulation""]",figure_caption,0.85,body_zone,unknown_like,none,True,True +20,14,image,,"[742, 890, 1031, 1021]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,15,image,,"[742, 1028, 1032, 1135]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,16,image,,"[740, 1142, 1033, 1275]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,17,figure_title,Fig. 12. Force-electrical conversion biomaterials for tissue regeneration and functional regulation. A) US-driven piezoelectric degradable spinal cord scaffolds. Reproduced with permission from Ref. [,"[69, 1297, 1121, 1489]",figure_caption,0.92,"[""figure_title label: Fig. 12. Force-electrical conversion biomaterials for tissue""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +20,18,number,20,"[586, 1513, 606, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,0,header,S. Yao et al.,"[71, 70, 145, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +21,2,paragraph_title,5.1. Tissue regeneration 5.1.1. Nerve,"[71, 108, 243, 168]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1. Tissue regeneration 5.1.1. Nerve""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +21,3,footer,,"[71, 150, 168, 168]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +21,4,text,"Researches have demonstrated that an electrical field environment can effectively promote neuronal differentiation and synaptogenesis, thereby accelerating the recovery of neural function. Specificall","[69, 171, 582, 441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,5,text,"Piezoelectric electroactive materials, due to their unique property of generating electrical signals in response to external stimuli, thereby promoting the growth and differentiation of neuronal cells","[69, 442, 582, 861]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,6,text,"It is worth noting that, in designing electrical stimulation neural conduit scaffolds, besides meeting the requirements of electrical stimulation, the structural design of the scaffold is equally cruc","[68, 861, 581, 1050]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,7,paragraph_title,5.1.2. Bone,"[71, 1070, 163, 1088]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1.2. Bone""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +21,8,text,"Bone tissue stands as the largest natural piezoelectric material in organisms, with its piezoelectricity originating from the oriented arrangement of collagen fibers. The surface of injured bone tissu","[69, 1090, 582, 1490]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,9,text,"femur within 6 weeks. Compared to direct electrical stimulation, direct +contact of the newly formed tissue with the material can more effec­ +tively amplify the electrical signals [212]. Cui et al. fab","[606, 107, 1120, 314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,10,text,"Similarly, the growth process of cartilage resembles that of bone cells, and cartilage regeneration poses a crucial challenge in osteoarthritis and cartilage defects. In promoting the regeneration of ","[607, 317, 1120, 566]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,11,text,Tendon disorders also represent a key challenge in the field of orthopedics. Studies have shown that devices based on piezoelectric conversion can regulate ion channels in tendon cells in vitro and mo,"[606, 566, 1120, 819]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,12,paragraph_title,5.1.3. Skin,"[610, 840, 697, 858]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1.3. Skin""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +21,13,text,"Wound healing is a complex and intricate biological process involving interactions among various cells and molecules. In this process, the guiding role of electric fields has been proven to be crucial","[607, 860, 1119, 986]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,14,text,"Normal epidermal cells form a transepithelial potential through their internal ion channels, which is the basis for the endogenous electric field in wounds. Cations (such as $ Na^{+} $) are primarily","[607, 987, 1120, 1216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,15,text,"Recent studies have confirmed the impact of the endogenous electric field in wounds on the healing rate. For example, in some disease states (such as diabetes), the absence or weakening of the endogen","[607, 1217, 1119, 1341]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,16,text,"To leverage electric fields for wound healing, researchers have developed a series of innovative technologies. Luo et al. ingeniously combined TENG with mature wound treatment devices, namely negative","[607, 1341, 1120, 1489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,17,number,21,"[586, 1514, 604, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,0,header,S. Yao et al.,"[71, 70, 145, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +22,2,text,generated by TENG is not only stable and highly safe but also has a significant migratory promotion effect on epithelial cells and drives macrophages to differentiate into the repair-oriented $ M_{2},"[70, 107, 582, 231]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,3,text,"Another innovative study by Sun et al. developed a passive and biodegradable piezoelectric suture. The suture is composed of a multilayer coaxial structure, including poly(lactic-co-glycolic acid), po","[69, 232, 581, 420]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,4,text,"In summary, electric fields play an important role in the wound healing process, and modern technological applications provide new ways to leverage electric fields for wound healing. By innovatively s","[69, 422, 582, 611]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,5,paragraph_title,5.2. Functional regulation 5.2.1. Brain,"[71, 631, 258, 692]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2. Functional regulation 5.2.1. Brain""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +22,6,footer,,"[71, 673, 167, 692]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +22,7,text,"Brain electrical stimulation (BES), a pioneering therapeutic and interventional approach in neurology, has been proven to influence neurotransmitter release and synaptic plasticity [220]. The underlyi","[69, 695, 582, 1030]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,8,text,"In terms of technological innovations, Zhao et al. reported a wearable neuromodulation stimulator that does not require an external battery, capable of modulating synaptic plasticity in both long-term","[69, 1030, 582, 1343]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,9,text,"It is worth noting that BES may exhibit different time frames in improving symptoms of various neurological diseases. For example, tremor and rigidity may respond immediately, while long-term issues s","[69, 1343, 582, 1490]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,10,text,"reactions caused by lead migration, including motor disorders, speech +impairments, cognitive difficulties, and emotional fluctuations. There­ +fore, the implementation of BES therapy requires strict pa","[606, 107, 1120, 295]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,11,paragraph_title,5.2.2. Heart,"[610, 316, 707, 335]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2.2. Heart""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +22,12,text,The application of force-electrically convertible materials in cardiac disease treatment primarily focuses on two major areas: cardiac pacemakers and myocardial patches (as shown in Fig. 12G and H). S,"[607, 338, 1120, 609]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,13,text,"As early as 1963, Parsonnet et al. pioneered an attempt to capture in vivo mechanical energy from the pulsatile expansion of the aorta through an implanted piezoelectric device [231]. In Chapter 2 of ","[607, 610, 1120, 838]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,14,text,"On the other hand, myocardial patches primarily address the issue of limited myocardial contractile function following myocardial infarction. Poor electrical conduction between myocardial tissues incr","[606, 840, 1120, 1109]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,15,text,"In summary, force-electrically convertible materials exhibit great potential for application in the field of cardiac disease treatment. Whether by providing a novel self-powering solution for cardiac ","[606, 1111, 1120, 1322]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,16,paragraph_title,5.2.3. Muscle,"[609, 1341, 714, 1360]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2.3. Muscle""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +22,17,text,"Muscle tissue serves as a pivotal component of organisms, accounting for more than half of the body mass and playing a crucial role in force generation, bodily movement, and internal organ support. It","[606, 1363, 1120, 1489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,18,number,22,"[586, 1513, 606, 1527]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,0,header,S. Yao et al.,"[70, 70, 146, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +23,2,text,"smooth muscle. Skeletal muscle is responsible for bodily activities, cardiac muscle controls heart contraction specifically, while smooth muscle is widely distributed in blood vessels and the digestiv","[67, 107, 581, 170]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,3,text,"When muscle tissue is injured, its regenerative capacity becomes particularly significant. In contrast to skin wound healing, muscle regeneration refers specifically to the repair process of damaged m","[68, 169, 584, 527]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,4,text,"role of motor neurons in the physiological environment, influencing +muscle cell proliferation rates and hypertrophy characteristics. For +instance, the addition of electrical stimulation to two-dimensi","[605, 107, 1120, 210]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,5,text,"In vitro cultures have also revealed various materials with beneficial effects on the adhesion and proliferation of myoblasts, as well as their myogenic differentiation. For example, negatively charge","[605, 211, 1121, 462]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,6,text,"Furthermore, Fang et al. prepared piezoelectric elastomer using a copolymerization method of bio-based diacids and diols (Fig. 12I). This material has an elastic modulus matching that of skeletal musc","[606, 463, 1121, 527]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,7,figure_title,A),"[88, 579, 120, 608]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +23,8,image,,"[92, 571, 694, 775]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,9,figure_title,B),"[693, 580, 725, 607]",figure_inner_text,0.9,"[""panel label / figure inner text: B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +23,10,image,,"[725, 575, 1110, 781]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,11,figure_title,C),"[89, 782, 120, 811]",figure_inner_text,0.9,"[""panel label / figure inner text: C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +23,12,figure_title,D),"[500, 784, 533, 812]",figure_inner_text,0.9,"[""panel label / figure inner text: D)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +23,13,image,,"[83, 794, 1103, 1071]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,14,figure_title,E) Piezoelectric anaigesia blocks Cancer-induced Bone Pain,"[88, 1053, 339, 1102]",figure_caption_candidate,0.85,"[""figure_title label: E) Piezoelectric anaigesia blocks Cancer-induced Bone Pain""]",figure_caption,0.85,body_zone,unknown_like,none,False,False +23,15,figure_title,F),"[408, 1068, 435, 1094]",figure_inner_text,0.9,"[""panel label / figure inner text: F)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +23,16,image,,"[79, 1098, 408, 1331]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,17,image,,"[408, 1091, 1104, 1320]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,18,figure_title,Fig. 13. Force-electrical conversion materials in regenerative medicine. A) US-induced wireless energy harvesting for potential retinal electrical stimulation. Reproduced with permission from Ref. [24,"[67, 1355, 1118, 1490]",figure_caption,0.92,"[""figure_title label: Fig. 13. Force-electrical conversion materials in regenerati""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +23,19,number,23,"[586, 1513, 607, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,0,header,S. Yao et al.,"[71, 70, 145, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +24,2,text,"enabling stretching and recovery movements. Under ultrasonic and mechanical stimulation, the piezoelectric charge of the PPBE scaffold can promote myogenic differentiation through the $ Ca^{2+} $ sig","[69, 106, 581, 273]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,3,text,"In summary, the regenerative capacity of muscle tissue is crucial for maintaining the normal function of organisms. Currently, researchers are exploring new therapeutic strategies and materials to imp","[69, 275, 582, 422]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,4,paragraph_title,5.2.4. Other,"[71, 442, 168, 461]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2.4. Other""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +24,5,text,"Besides the aforementioned representative applications of electromechanical conversion materials in tissue regeneration and functional repair, there exist a series of special applications such as elec","[68, 463, 582, 587]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,6,text,"In the field of retinal electrical stimulation, Jiang et al. prepared a lead-free, ultra-thin composite piezoelectric patch (Fig. 13A). Through optimized manufacturing techniques and the addition of m","[69, 588, 582, 903]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,7,text,"The vagus nerve, as a composite of motor and sensory fibers, has extensive connections with various body systems. Electrical stimulation of the vagus nerve is an effective means of regulating neural a","[68, 903, 582, 1299]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,8,text,"In the field of pain relief, Yin et al. developed an US-driven electrical stimulant for blocking cancer-induced bone pain (CIBP) $ [244] $. They utilized BTO nanosheets to achieve single-cell-level e","[68, 1300, 581, 1425]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,9,text,"Recently, the construction of electrically sensitive functional cells and the regulation of cell secretion function through electrical stimulation have become research hotspots. Zhao et al. utilized p","[68, 1425, 582, 1489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,10,text,"PVDF films to generate suitable electrical stimulation to stimulate +electrically sensitive cells derived from the pancreatic β-cell line 1.1E7 +[245]. These cells were designed to express insulin, as w","[607, 106, 1120, 399]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,11,text,"In summary, the application of electromechanical conversion materials in the medical field demonstrates broad prospects and potential. From retinal electrical stimulation to artificial cochleas, from ","[607, 400, 1120, 631]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,12,paragraph_title,5.3. Disease treatment,"[609, 652, 773, 672]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3. Disease treatment""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +24,13,text,"In recent years, the disease treatment based on tissue regeneration has received increasing attention, and electrical stimulation has been studied to some extent as one of the strategies for disease t","[606, 694, 1120, 968]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,14,paragraph_title,5.3.1. Drug delivery,"[609, 987, 758, 1007]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3.1. Drug delivery""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +24,15,text,"Drug delivery systems have become a hot research topic in the biomedical field, driven by the huge clinical demand for targeted therapies, in the hope of bringing more survival benefits to patients. R","[606, 1009, 1120, 1385]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,16,text,"In stimuli-responsive drug delivery systems, biopolymers, NPs, microneedles, and liposomes are used as common drug carriers that can be electrically stimulated and controlled by electroactive material","[606, 1385, 1121, 1490]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,17,number,24,"[586, 1514, 606, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,0,header,S. Yao et al.,"[71, 70, 145, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +25,2,image,,"[244, 110, 940, 851]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +25,3,figure_title,Fig. 14. Electroactive materials and devices for disease treatment. A) Working mechanism of the F-MN device composed of F-TENG and dissolving MN patch. Reproduced with permission from Ref. [252]. Copy,"[66, 866, 1121, 1041]",figure_caption,0.92,"[""figure_title label: Fig. 14. Electroactive materials and devices for disease tre""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +25,4,text,"controlled drug release. Based on this, Wang et al. proposed a wearable, self-powered MN patch, which was integrated with a flexible friction nanogenerator (F-TENG), aiming at deep tumor therapy $ [2","[68, 1064, 581, 1336]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,5,text,"In vitro transdermal drug delivery based on electroactive materials and devices mainly relies on electroporation, electrophoresis, and iontophoresis, which impose limitations on drug delivery efficien","[69, 1336, 582, 1484]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,6,text,"the TENG output up to 70 V [253]. RBCs loaded with DOX were used as +an antitumor drug delivery system (DDS). After loading DOX, the +erythrocyte membrane was very stable with little DOX release. How­ +e","[606, 1063, 1121, 1464]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,7,number,25,"[586, 1513, 606, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,0,header,S. Yao et al.,"[71, 70, 145, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +26,2,paragraph_title,5.3.2. Catalytic therapy,"[71, 107, 245, 127]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3.2. Catalytic therapy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +26,3,text,"In the last decade, nanocatalysts designed for localized generation of ROS have been considered as a promising strategy for disease treatment to overcome drug resistance and reduce side effects. Howev","[68, 129, 582, 400]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,4,text,"In the process of enhancing the catalytic performance of electroactive materials, electric field stimulation can effectively regulate the electron mobility, electron polarization structure and electro","[68, 400, 582, 1071]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,5,text,"Piezoelectric biomaterials can directly convert mechanical pressure into an electrical response when stimulated by US, thus creating a large dynamic built-in electric field [262,263]. Under the action","[68, 1070, 582, 1489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,6,paragraph_title,5.3.3. Electrotherapy,"[609, 108, 764, 127]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3.3. Electrotherapy""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +26,7,text,The use of electrical stimulation in the treatment of disease stems from the discovery of the existence of an endogenous electric field in organisms. This electric field is important in embryonic deve,"[606, 130, 1120, 672]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,8,text,"In addition, Zulmari et al. used piezoelectric $ [P(VDF-TrFE)] $ microparticles (MPs) to induce IRE in 4T1 breast cancer cells and thereby kill the cells $ [251] $. Under US stimulation, MPs located","[607, 672, 1119, 944]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,9,text,"Electrical stimulation can not only directly induce tumor cell death, but also recruit immune cells for cancer immunotherapy. Li et al. prepared a fabric DC-TENG consisting of eight repetitively woven","[606, 945, 1120, 1280]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,10,paragraph_title,6. Conclusions and future perspectives,"[609, 1301, 918, 1322]",section_heading,0.85,"[""paragraph_title label with numbering: 6. Conclusions and future perspectives""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +26,11,text,"In the field of biomedical science, biomaterials and electro-stimulation devices based on force-electric conversion, including PENGs and TENGs, are emerging as novel electrostimulation methods that do","[605, 1343, 1121, 1489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,12,number,26,"[586, 1514, 606, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +27,0,header,S. Yao et al.,"[71, 70, 145, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +27,1,header,Biomaterials 320 (2025) 123288,"[933, 70, 1120, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +27,2,text,"From the perspective of materials, optimizing the performance of force-electrically convertible materials is crucial for future advancements. Material selection must comprehensively consider factors s","[68, 106, 583, 462]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,3,text,"In terms of device design, integrating suitable materials into a complete device is a topic that requires in-depth research. This involves structural design, encapsulation strategies, integration, and","[68, 462, 582, 1112]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,4,text,"Despite the advantages of battery-free and sustainable electro-stimulation methods based on force-electricity conversion, the instability and uncontrollability of their tiny mechanical energy conversi","[69, 1110, 582, 1299]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,5,text,"Moreover, not only the application of force-electric materials in biomedicine but also the entire field of electrostimulation therapy in biomedicine relies on the advancement of basic biological mecha","[68, 1300, 582, 1489]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,6,figure_title,"Table 2 +Potential risks and clinical translational challenges of force-electric biomaterials and devices.","[607, 107, 1118, 166]",table_caption,0.9,"[""table prefix matched: Table 2\nPotential risks and clinical translational challenge""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +27,7,table,"
TypePotential risksClinical translation challenges
Piezoelectric materialPiezoelectric ceramicsChronic inflamma","[613, 168, 1117, 598]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +27,8,text,for the further optimization and application of electrostimulation therapy.,"[607, 628, 1118, 670]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,9,text,"In summary, electrostimulation devices based on force-electric conversion have broad application prospects in the biomedical field. However, to achieve their true clinical application and commercializ","[606, 671, 1120, 861]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,10,paragraph_title,CRediT authorship contribution statement,"[608, 881, 942, 902]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: CRediT authorship contribution statement""]",subsection_heading,0.6,body_zone,body_like,none,True,True +27,11,text,"Shuncheng Yao: Writing – original draft, Conceptualization. Xi Cui: Writing – original draft, Conceptualization. Chao Zhang: Supervision. Wenguo Cui: Supervision. Zhou Li: Writing – review & editing, ","[607, 921, 1119, 1007]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,12,paragraph_title,Ethics approval and consent to participate,"[608, 1027, 942, 1049]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Ethics approval and consent to participate""]",subsection_heading,0.6,body_zone,body_like,none,True,True +27,13,text,This review article does not require any ethical approval or allied consent for publication.,"[608, 1069, 1118, 1111]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,14,paragraph_title,Declaration of competing interest,"[608, 1132, 875, 1153]",body_paragraph,0.5,"[""backmatter boundary candidate: Declaration of competing interest""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True +27,15,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[606, 1173, 1119, 1237]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,16,paragraph_title,Acknowledgments,"[609, 1257, 756, 1278]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +27,17,text,"S.Y. and X.C. contributed equally to this work. This work was supported by the National Key R&D project from Minister of Science and Technology, China (2022YFB3804700), Beijing Natural Science Foundat","[606, 1299, 1120, 1447]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,18,number,27,"[586, 1513, 606, 1528]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,0,header,S. Yao et al.,"[71, 70, 144, 87]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,1,header,Biomaterials 320 (2025) 123288,"[933, 71, 1120, 86]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False +28,2,paragraph_title,Data availability,"[71, 107, 204, 127]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data availability""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True +28,3,text,No data was used for the research described in the article.,"[93, 150, 513, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,4,paragraph_title,References,"[71, 190, 161, 209]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True +28,5,reference_content,". Cwynarski, G. Iacoboni, E. Tholouli, T. Menne, D.A. 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Wang""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +33,45,number,33,"[586, 1514, 606, 1528]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +34,0,header,S. Yao et al.,"[72, 71, 144, 87]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False +34,1,header,Biomaterials 320 (2025) 123288,"[934, 71, 1119, 86]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False +34,2,reference_content,"photoelectric-catalytic action provided by triboelectric nanogenerator, NanoMicro Lett. 13 (2021), https://doi.org/10.1007/s40820-021-00695-3.","[110, 110, 566, 139]",reference_item,0.85,"[""reference content label: photoelectric-catalytic action provided by triboelectric nan""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +34,3,reference_content,"[262] Q. Truong Hoang, D.Y. Kim, H.S. Park, W. Jang, T.G. Nguyen Cao, J.H. Kang, Y.T. Ko, S.J. Mun, S.H. Bhang, M.S. Shim, K.W. Bang, Oxygen-supplying piezocatalytic therapy of hypoxic tumors by intra","[73, 140, 576, 188]",reference_item,0.85,"[""reference content label: [262] Q. Truong Hoang, D.Y. Kim, H.S. Park, W. Jang, T.G. Ng""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +34,4,reference_content,"responsive multicompartmental carriers with sequential drug release capability, Adv. Funct. Mater. 34 (2024), https://doi.org/10.1002/adfm.202306078.","[650, 110, 1111, 140]",reference_item,0.85,"[""reference content label: responsive multicompartmental carriers with sequential drug ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True +34,5,reference_content,"[263] H. Quan Truong, V. Ravichandran, C. Thuy Giang Nguyen, J.H. Kang, Y.T. Ko, T.I. Lee, M.S. Shim, Piezoelectric Au-decorated ZnO nanorods: ultrasound-triggered generation of ROS for piezocatalytic","[612, 140, 1114, 203]",reference_item,0.85,"[""reference content label: [263] H. Quan Truong, V. Ravichandran, C. Thuy Giang Nguyen,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True +34,6,number,34,"[586, 1514, 605, 1528]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/RKSLQRIM/block_trace.csv b/tests/fixtures/ocr_real_papers/RKSLQRIM/block_trace.csv new file mode 100644 index 00000000..ed71183e --- /dev/null +++ b/tests/fixtures/ocr_real_papers/RKSLQRIM/block_trace.csv @@ -0,0 +1,377 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +2,0,header,Journal Pre-proof,"[494, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p2 y=68/1584"", ""page_1_preproof_cover_dropped_upstream""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +2,1,doc_title,Engineering electroactive and biocompatible tetra(aniline)-based terpolymers with tunable intrinsic antioxidant properties in vivo,"[139, 143, 1082, 202]",paper_title,0.8,"[""page-1 zone title_zone: Engineering electroactive and biocompatible tetra(aniline)-b""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +2,2,text,"Irrum Mushtaq, a* Iram Mushtaq, b Zareen Akhter, a* Iram Murtaza, b Samina Qamar, a Sidra Ayub, b Bushra Mirza, b Tehmeena Maryum Butt, a, Naveed Kausar Janjua, a Faiz Ullah Shah, c Farasat Zaman","[147, 214, 1083, 288]",authors,0.8,"[""page-1 zone author_zone: Irrum Mushtaq, a* Iram Mushtaq, b Zareen Akhter, a* Iram Mur""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +2,3,text," $ ^{a} $Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan","[140, 354, 860, 386]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $Department of Chemistry, Quaid-i-Azam University, Is""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +2,4,text," $ ^{b} $ Department of Biochemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan","[140, 404, 886, 436]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{b} $ Department of Biochemistry, Quaid-i-Azam University""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +2,5,text,"Chemistry of Interfaces, Luleå University of Technology, SE-97187 Luleå, Sweden","[139, 456, 879, 488]",affiliation,0.8,"[""page-1 zone affiliation_zone: Chemistry of Interfaces, Lule\u00e5 University of Technology, SE-""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +2,6,text," $ ^{d} $ Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, SE-171 74 Solna, Sweden","[139, 503, 1082, 561]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{d} $ Department of Women\u2019s and Children\u2019s Health, Karoli""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True +2,7,text,*Corresponding authors:,"[140, 622, 370, 651]",authors,0.8,"[""page-1 zone author_zone: *Corresponding authors:""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +2,8,text,"Irrum Mushtaq, Email: irrum.mushtaq@chem.qau.edu.pk (correspondence post-publication) +Zareen Akhter, Email: zareen_a@qau.edu.pk (correspondence post-publication) +Farasat Zaman, Email: farasat.zaman@ki","[139, 667, 1073, 752]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Irrum Mushtaq, Email: irrum.mushtaq@chem.qau.edu.pk (corresp""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +2,9,number,1,"[1065, 1460, 1082, 1484]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +3,0,header,Journal Pre-proof,"[494, 67, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p3 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +3,1,paragraph_title,Abstract,"[138, 144, 255, 178]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,body_zone,heading_like,short_fragment,True,True +3,2,abstract,"Under different pathological conditions, high levels of reactive oxygen species (ROS) cause substantial damage to multiple organs. To counter these ROS levels in multiple organs, we have engineered hi","[136, 222, 1088, 866]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +3,3,text,"Keywords: tetra(aniline), electroactive terpolymers, thermal stability, antioxidant, biocompatible, diabetes","[137, 901, 1083, 989]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +3,4,number,2,"[1065, 1460, 1083, 1483]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Journal Pre-proof,"[494, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p4 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +4,1,paragraph_title,1. Introduction,"[140, 147, 337, 176]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,2,text,There is a critical balance between reactive oxygen species (ROS) produced as a result of cellular metabolism and their neutralization in the body. Disturbance of this level with any exogenous or endo,"[138, 227, 1087, 699]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,text,"Intrinsic antioxidant polymers are among the emerging class of materials used in antioxidative treatment for applications in regenerative medicines, tissue engineering, and drug delivery. $ ^{4,12-17}","[137, 740, 1088, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,number,3,"[1065, 1461, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,Journal Pre-proof,"[494, 68, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p5 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +5,1,text,"pathological conditions with oxidative stress, previously designed polymers face challenges of being less biodegradable or low in potency for their intrinsic electroactive antioxidant behavior when te","[137, 147, 1086, 285]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,2,text,"In the study presented herein, we aimed to use a new approach to overcome the previous deficiencies in polymers by adding tetra(aniline) to exploit the antioxidant properties of TANI. Tetra(aniline) i","[137, 327, 1087, 1242]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,3,text,Here we demonstrate synthesize of tetra(aniline)-based terpolymers which are not only electroactive but also possess tunable intrinsic antioxidant properties and are biodegradable. We show that TANI i,"[138, 1282, 1086, 1421]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,number,4,"[1065, 1461, 1084, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Journal Pre-proof,"[494, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p6 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +6,1,text,"thermal properties, whereas PEG and fumaric acid moieties control the hydrophilic, and biocompatible characteristics as well as to make them biodegradable by introducing ester linkages.","[138, 147, 1085, 283]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,2,text,"Currently no data is available whether TANI-based material can exert antioxidant effects to overcome ROS production in vivo under diabetic condition, as oxidative stress is known to be high in diabete","[137, 327, 1085, 468]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,3,paragraph_title,2. Experimental,"[139, 510, 348, 540]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Experimental""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +6,4,paragraph_title,2.1. Materials and methods,"[140, 573, 411, 600]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Materials and methods""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,5,text,"Polyethylene glycol (PEG; $ M_w = 6000 \, g mol^{-1} $, Sigma-Aldrich) was azeotropically distilled from dried toluene prior to use. Fumaryl chloride (FC) was purchased from Sigma-Aldrich and distill","[136, 629, 1086, 989]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,paragraph_title,2.2. Synthesis of boc-protected amino-capped aniline tetramer (TANI),"[139, 1015, 827, 1043]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Synthesis of boc-protected amino-capped aniline tetrame""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,7,text,"The details of terpolymer synthesis steps are explained in Fig. 1. TANI was synthesized in the boc-protected state in three steps as reported earlier. Briefly, first step was the synthesis of nitro-ca","[138, 1088, 1085, 1410]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,number,5,"[1065, 1460, 1083, 1483]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Journal Pre-proof,"[494, 67, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p7 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +7,1,text,"FTIR (solid sample, cm⁻¹) v: 3467, 3360, 3010, 2981, 2925, 1693, 1621, 1510, 1452, 1389, 1313, 1288, 1149, 1061, 961, 833, 761, 649. MS (ESI) m/z: 704.3 [M + Na]⁺.","[140, 145, 1082, 221]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,2,paragraph_title,2.3. Synthesis of oligo (poly(ethylene glycol) fumarate) (PF-100),"[137, 251, 777, 279]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Synthesis of oligo (poly(ethylene glycol) fumarate) (PF""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,3,text,"PF-100 was synthesized according as reported earlier. $ ^{45} $ Briefly, dried PEG (1.1 mmol) was condensed with fumaryl chloride (1 mmol) in the presence of Et₃N (2 mmol) in dried DCM under nitrogen ","[138, 322, 1087, 643]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,paragraph_title,"2.4. Synthesis of terpolymers (P-19, P-37)","[139, 669, 558, 697]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Synthesis of terpolymers (P-19, P-37)""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,5,text,Terpolymers were synthesized by using solution polycondensation reaction as shown in scheme,"[139, 741, 1083, 768]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,image,,"[152, 795, 474, 1222]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,7,vision_footnote,dissolved in DCM.,"[141, 1238, 328, 1261]",footnote,0.7,"[""vision_footnote label: dissolved in DCM.""]",footnote,0.7,body_zone,body_like,short_fragment,True,True +7,8,text,1. PEG (dried by azeotropic distillation with dried toluene) and TANI predetermined amounts of total 1.1 mmol were added into a prebaked round bottom flask under N₂ atmosphere and stirred in dried DCM,"[490, 796, 1086, 1213]",body_paragraph,0.6,"[""reference-like pattern: 1. PEG (dried by azeotropic distillation with dried toluene)""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True +7,9,text,Scheme 1. Synthesis of boc-protected and deprotected terpolymers,"[140, 1307, 715, 1332]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,number,6,"[1065, 1461, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Journal Pre-proof,"[495, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p8 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +8,1,text,The reaction mixture was stirred at 0 °C for 1 hour and then maintained to room temperature for additional 48 hours. Precipitation occurred on pouring the reaction mixture into dried diethyl ether. Th,"[138, 148, 1087, 452]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,2,paragraph_title,"2.5. Deprotected terpolymers (L-19, L-37)","[139, 493, 561, 520]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Deprotected terpolymers (L-19, L-37)""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,3,text,Terpolymers (P-19 and P-37) were deprotected by using TFA 50 % solution in DCM at 0 °C for 2 hours. The solution was rotary evaporated (with DCM × 4 times) to remove excess TFA followed by treatment w,"[136, 565, 1087, 926]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,2.6. Characterization of engineered terpolymers,"[140, 953, 619, 980]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Characterization of engineered terpolymers""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,5,text,"We next characterized the engineered terpolymers. First, FTIR spectra were recorded on Bruker Tensor-II Germany in the range of 4000-500 cm⁻¹. We used Bruker Ascend Aeon WB 400 (Bruker BioSpin AG, Fäl","[137, 1024, 1086, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,number,7,"[1066, 1461, 1083, 1483]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,Journal Pre-proof,"[494, 67, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p9 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +9,1,abstract,Hg/Hg₂Cl₂ (saturated calomel electrode) as the reference electrode and Pt wire as the counter electrode at 50 mV/s scan rate in 1M H₂SO₄. Gel permeation chromatography (GPC) of the samples was conduct,"[136, 145, 1090, 1333]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True +9,2,paragraph_title,2.7. In vitro hydrolytic degradation analysis,"[139, 1375, 584, 1403]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. In vitro hydrolytic degradation analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +9,3,number,8,"[1066, 1461, 1082, 1483]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,Journal Pre-proof,"[494, 68, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p10 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +10,1,text,"The biodegradation of the synthesized material was observed by measuring the change in viscosity of their solution with time. $ ^{46} $ Sample solutions in 1x PBS (5 wt %, pH=7.4) were prepared and in","[138, 147, 1086, 338]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,2,paragraph_title,2.8. Co-culture of chondrocytes with terpolymers and cellular toxicity,"[139, 384, 826, 411]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Co-culture of chondrocytes with terpolymers and cellula""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,3,text,"ATDC-5 chondrocytes in proliferation stage were exposed to different concentrations (0.1, 0.5 and 1 mg/mL) of synthesized terpolymers. The terpolymers were directly diluted in Dulbecco's Modified Eagl","[137, 454, 1088, 925]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,paragraph_title,2.9. Antioxidant (Radical scavenging activity) assay in vitro,"[144, 968, 737, 994]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Antioxidant (Radical scavenging activity) assay in vitr""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +10,5,text,"Antioxidant assay of the materials was determined by using a model stable free radical DPPH. 1 mL of aqueous sample solution (1mg/mL) was added to 1mL of DPPH solution (0.1mM, in methanol), incubated ","[138, 1039, 1086, 1414]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,number,9,"[1065, 1461, 1083, 1482]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,Journal Pre-proof,"[494, 68, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p11 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +11,1,text,"using the formula: % RSA = (A_{control} - A_{sample} / A_{Control}) × 100, where A_{control} is the absorbance of control (DPPH + methanol + water) and A_{sample} is the absorbance of sample (DPPH + m","[138, 146, 1085, 284]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,2,paragraph_title,2.10. Antioxidative effects of terpolymers in diabetic rats,"[139, 400, 700, 427]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. Antioxidative effects of terpolymers in diabetic rats""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +11,3,text,All animal experiments were conducted according to international guidelines and all the procedures were approved by the local institutional bioethical board with ethical permit number BEC-FBS-QAU2017-,"[137, 471, 1087, 1221]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,paragraph_title,2.11. Blood glucose levels and oxidative and antioxidative profiling in the serum,"[139, 1260, 931, 1288]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.11. Blood glucose levels and oxidative and antioxidative p""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +11,5,text,Blood glucose of diabetic rats was measured before and after systemic administration of terpolymers as reported previously. $ ^{41} $ Oxidative and antioxidative profile was estimated by,"[139, 1316, 1085, 1400]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,number,10,"[1054, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,header,Journal Pre-proof,"[494, 67, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p12 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +12,1,text,"performing reactive oxygen species (ROS) $ ^{51} $, superoxide dismutase (SOD) $ ^{52} $, catalase (CAT) $ ^{53} $, and reduced glutathione (GSH) $ ^{54} $ assays on the serum of the experimental rat ","[140, 141, 1086, 285]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,2,paragraph_title,"2.12. Liver profiling, ALP analysis and histopathology of heart tissue","[139, 398, 821, 427]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.12. Liver profiling, ALP analysis and histopathology of he""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +12,3,text,"Levels of liver enzyme Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) were profiled by using through AMP Diagnostic kit, Austria as per instructions provided in the kit. Alkaline ","[137, 451, 1086, 983]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,paragraph_title,2.13. Statistical analysis,"[140, 1021, 384, 1049]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.13. Statistical analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +12,5,text,All statistical comparisons were performed by using GraphPad Prism 5 and statistical difference between various groups was determined by applying One-way ANOVA (Analysis of variance) in statistix 8.1.,"[137, 1078, 1088, 1382]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,number,11,"[1054, 1461, 1082, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,0,header,Journal Pre-proof,"[495, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p13 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +13,1,paragraph_title,3. Results and discussion,"[139, 203, 452, 231]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results and discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +13,2,paragraph_title,3.1. Synthesis and characterization of electroactive terpolymers,"[140, 266, 768, 292]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Synthesis and characterization of electroactive terpoly""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +13,3,text,"PEG fumarate (PF-100), boc-protected terpolymers (P-19 and P-37), and deprotected electroactive terpolymers (L-19 and L-37) were synthesized as shown in Scheme 1. The reaction between PEG and boc-prot","[137, 338, 1086, 753]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,Representative FTIR spectra are shown in Figure 1. FTIR spectrum for P-100 (Figure 1a) showed ester carbonyl (C=O) stretch at 1720 cm⁻¹. PEG methylene protons (CH₂) and ether linkage (H₂C-O-CH₂) showe,"[136, 795, 1087, 1434]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,number,12,"[1054, 1461, 1083, 1483]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,0,header,Journal Pre-proof,"[494, 68, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p14 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +14,1,text,characteristic stretches for boc-protected TANI in respective regions. The stretch band for ester carbonyl (C=O) at 1711 cm⁻¹ was appeared with disappearance of stretch band for terminal hydroxyl of t,"[136, 144, 1088, 1170]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,2,number,13,"[1054, 1461, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,0,header,Journal Pre-proof,"[494, 67, 729, 97]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p15 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +15,1,chart,,"[150, 147, 514, 632]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +15,2,figure_title,"Figure 1. FTIR spectra. (a) PF-100, (b) TANI, (c) P-37 and, (d) L-37. Major assignments in (c): 3400 cm⁻¹ (N-H stretch), 2903 cm⁻¹ (PEG C-H stretch), 2830 cm⁻¹ (Boc ter.C-H stretch), 1711-1665 cm⁻¹ (C","[553, 156, 1128, 682]",figure_caption,0.92,"[""figure_title label: Figure 1. FTIR spectra. (a) PF-100, (b) TANI, (c) P-37 and, ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +15,3,chart,,"[142, 681, 555, 917]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +15,4,figure_title,"Figure 2. $ ^{1} $H NMR spectra. (a) P-37 and, (b) L-37. Major signals in (a) δ ppm: 1.41 (Boc protons), 3.61 (PEG protons), 4.32 (CH $ _{2} $ protons attached with ester), 6.89-6.81 (fumaric moiety ","[135, 965, 1087, 1220]",figure_caption,0.92,"[""figure_title label: Figure 2. $ ^{1} $H NMR spectra. (a) P-37 and, (b) L-37. Ma""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +15,5,figure_title,Table 1. Feed ratio and characterization of polymer and terpolymers,"[140, 1402, 851, 1431]",table_caption,0.9,"[""table prefix matched: Table 1. Feed ratio and characterization of polymer and terp""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +15,6,number,14,"[1054, 1460, 1084, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,0,figure_title,Journal Pre-proof,"[494, 66, 729, 97]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p16 y=66/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +16,1,table,
SampleTANIPEGFA$ M_{n}^{a} $$ M_{w}^{a} $PDI $ ^{a} $$ \eta_{inh} $WaterConductivity
Co,"[75, 140, 1147, 696]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +16,2,text,Determined by GPC using THF as the eluent solvent. Soluble at room temperature. $ n_{inh} $ of the sample (5 wt % in water) was determined by using Ubbelohde viscometer at room temperature.,"[137, 712, 1084, 805]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,3,paragraph_title,Electrochemical characterization of terpolymers,"[137, 846, 644, 875]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrochemical characterization of terpolymers""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +16,4,text,We next assessed electrochemistry of the synthesized terpolymers by using UV-vis spectroscopy and cyclic voltammetry. Figure 3A shows the characteristic UV-vis spectra of terpolymers in different oxid,"[136, 918, 1087, 1223]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,5,text,"On doping of the material with CSA (ES-19 and ES-37), peak at 312 nm slightly blue shifted to 305 nm while the peak at 585 nm was diminished with new peaks raised for polaron and delocalized polaron a","[137, 1264, 1086, 1407]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,6,number,15,"[1054, 1459, 1084, 1485]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,0,header,Journal Pre-proof,"[495, 67, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p17 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +17,1,figure_title,"of L-37 showing one pair of reversible redox peaks at a mean peak potential (E₁/₂) of 0.45 V. The appearance of single redox pair ascribed to the conversion of LEB to EB state of TANI.⁴⁶,⁵⁰ Peak curre","[138, 146, 1084, 341]",figure_caption_candidate,0.85,"[""figure_title label: of L-37 showing one pair of reversible redox peaks at a mean""]",figure_caption,0.85,body_zone,legend_like,none,False,False +17,2,chart,,"[148, 385, 492, 672]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +17,3,chart,,"[509, 382, 882, 675]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +17,4,figure_title,"Figure 3. Electroactivity of the terpolymers. (A) UV-Vis spectra of terpolymer solution (in water at room temperature) in different oxidation state, (a) L-37 (324 nm for benzenoid ring π-π* transition","[136, 724, 1087, 1248]",figure_caption,0.92,"[""figure_title label: Figure 3. Electroactivity of the terpolymers. (A) UV-Vis spe""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +17,5,number,16,"[1055, 1461, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,0,header,Journal Pre-proof,"[495, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p18 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +18,1,paragraph_title,Thermal properties analysis,"[140, 147, 436, 173]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Thermal properties analysis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +18,2,text,We performed thermal analysis of polymers and engineered terpolymers by using TGA and DSC. The results of TGA are summarized in Table 2 and thermograms are shown in Figure 4a. We found $ T_i $ (decom,"[136, 218, 1086, 745]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,3,text,"Next, DSC was used to determine the $ T_m $, $ T_c $, and $ X_c $ of the polymer and terpolymers from second heating cycle. DSC data is given in Table 2. Figure 4b showed the decrease in $ T_m $ a","[137, 786, 1086, 1035]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,4,number,17,"[1054, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,0,header,Journal Pre-proof,"[494, 67, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p19 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +19,1,chart,,"[147, 151, 530, 456]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +19,2,chart,,"[563, 150, 945, 458]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +19,3,figure_title,Figure 4. Thermal properties of polymer and terpolymers. (a) TGA thermograms was measured at the temperature range of 25-600 °C under nitrogen atmosphere showed thermal stability increased on increasi,"[136, 503, 1087, 756]",figure_caption,0.92,"[""figure_title label: Figure 4. Thermal properties of polymer and terpolymers. (a)""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +19,4,figure_title,Table 2. Thermal properties of the polymer and terpolymers.,"[140, 796, 772, 825]",table_caption,0.9,"[""table prefix matched: Table 2. Thermal properties of the polymer and terpolymers.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +19,5,table,
Samples$ T_{i} $$ T_{m} $$ T_{c} $$ \Delta H_{m} $$ X_{c} $
( $ ^{\circ} $C) $ ^{a} $( $ ^{\circ} $C)
Terpolymers CodesIC $ _{50} $ (mg/mL)
L-190.72
L-370.05
ES-190.10
ES-370,"[132, 938, 548, 1221]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +24,7,text,Systemic administration of terpolymers prevents ROS generation in diabetic rats,"[137, 1294, 977, 1324]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +24,8,number,23,"[1053, 1459, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +25,0,header,Journal Pre-proof,"[494, 67, 730, 97]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p25 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +25,1,text,"After confirming in vitro antioxidative effects of terpolymers as shown in Figure 8a-b, we next expanded our studies to investigate whether terpolymers are biologically active and prevent ROS in diabe","[136, 144, 1088, 1282]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +25,2,paragraph_title,Therapeutic scavenging activity of terpolymers in diabetic rats,"[139, 1360, 790, 1390]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Therapeutic scavenging activity of terpolymers in diabetic r""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +25,3,number,24,"[1053, 1460, 1084, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +26,0,header,Journal Pre-proof,"[494, 67, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p26 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +26,1,text,"We next measured the therapeutic scavenging activity of the synthesized terpolymers by using assays against superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH). As expected, we observed s","[138, 146, 1088, 617]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +26,2,text,"We noted that GSH activity was significantly suppressed in alloxan treated rats, but systemic treatment with terpolymers significantly improved GSH levels (Figure 9c). Interestingly, L-37 completely r","[136, 661, 1088, 1408]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +26,3,number,25,"[1053, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +27,0,header,Journal Pre-proof,"[494, 67, 729, 97]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p27 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +27,1,text,"resulting into severe decrease in the total number of beta cells. All taken together, these data show that exogenous administration of these synthesized terpolymers not only exerts antioxidant effects","[137, 146, 1087, 286]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +27,2,figure_title,(a),"[145, 401, 203, 452]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +27,3,chart,,"[153, 416, 532, 866]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,4,figure_title,(c),"[145, 847, 203, 893]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +27,5,chart,,"[576, 414, 953, 885]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,6,chart,,"[150, 849, 533, 1321]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,7,chart,,"[574, 856, 953, 1333]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +27,8,number,26,"[1053, 1460, 1084, 1485]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +28,0,header,Journal Pre-proof,"[494, 67, 730, 97]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p28 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +28,1,figure_title,"Figure 9. Antioxidant potential of terpolymers investigated in-vivo. Terpolymers were administered systemically to diabetic and normal rats as explained in methods, serum was collected to measure (a) ","[136, 145, 1087, 341]",figure_caption_candidate,0.92,"[""figure_title label: Figure 9. Antioxidant potential of terpolymers investigated ""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +28,2,paragraph_title,Terpolymers improve liver profiling,"[139, 382, 521, 412]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Terpolymers improve liver profiling""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True +28,3,text,"We assessed liver enzymes activity in response to systemic treatment with terpolymers (Figure 10a, 10b). Significantly increased levels of liver enzymes ALT and AST were observed in alloxan treated di","[136, 452, 1088, 871]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +28,4,figure_title,(a),"[303, 901, 349, 941]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +28,5,chart,,"[153, 938, 441, 1269]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +28,6,figure_title,(b),"[614, 901, 662, 941]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +28,7,chart,,"[462, 952, 752, 1287]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +28,8,figure_title,(c),"[933, 901, 977, 941]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +28,9,chart,,"[776, 955, 1073, 1294]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +28,10,figure_title,"Figure 10. Liver profiling in diabetic rats. Terpolymers were administered systemically to diabetic and normal rats as explained in methods, serum was collected to measure (a) ALT level","[136, 1324, 1084, 1408]",figure_caption_candidate,0.92,"[""figure_title label: Figure 10. Liver profiling in diabetic rats. Terpolymers wer""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +28,11,number,27,"[1053, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +29,0,header,Journal Pre-proof,"[494, 68, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p29 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +29,1,text,"(b) AST level, and (c) ALP level. Mean for $ n = 3 \pm SD $, *significant to normal group, #significant to the alloxan group, p < 0.05.","[138, 147, 1085, 230]",frontmatter_noise,0.7,"[""keyword-like block: (b) AST level, and (c) ALP level. Mean for $ n = 3 \\pm SD $""]",frontmatter_noise,0.7,tail_nonref_hold_zone,unknown_like,none,False,False +29,2,paragraph_title,Effects of terpolymers on bone health related markers,"[138, 258, 704, 284]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effects of terpolymers on bone health related markers""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +29,3,text,"We detected high levels of ALP in the serum of alloxan-treated rats when compared to normal rats, whereas systemic treatment with ES-37 and L-37 significantly decreased ALP levels (Figure 10c). Raised","[136, 333, 1088, 1351]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +29,4,number,28,"[1053, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +30,0,header,Journal Pre-proof,"[495, 67, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p30 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +30,1,figure_title,(a),"[382, 157, 426, 198]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +30,2,chart,,"[152, 204, 561, 517]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +30,3,figure_title,(b),"[808, 158, 856, 198]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +30,4,image,,"[666, 207, 822, 349]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +30,5,image,,"[838, 208, 992, 348]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +30,6,image,,"[666, 364, 822, 506]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +30,7,image,,"[838, 365, 992, 505]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +30,8,figure_title,Figure 11. Cell viability/proliferation assay in cultured chondrocytes. (a) Polymer and terpolymers were used at different concentrations as indicated and co-incubated with ATDC-5 chondrocytes for 72 ,"[136, 569, 1088, 823]",figure_caption_candidate,0.92,"[""figure_title label: Figure 11. Cell viability/proliferation assay in cultured ch""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +30,9,paragraph_title,Effects on lipid profiling and histopathological examination of heart tissues,"[140, 935, 917, 963]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effects on lipid profiling and histopathological examination""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +30,10,text,"Diabetes-induced oxidative stress affects the heart health leading to various cardiac complications. $ ^{3} $ Lipid profile is a test for assessment of heart disease risk. Therefore, we also investiga","[137, 990, 1088, 1406]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +30,11,number,29,"[1053, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +31,0,header,Journal Pre-proof,"[494, 67, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p31 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +31,1,text,"function of very low-density lipoproteins in circulation. $ ^{81,82} $ In the present study the elevated TBARS, triglyceride and cholesterol levels in diabetic rats are consistent with the previous fi","[137, 145, 1086, 284]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +31,2,figure_title,(a),"[305, 420, 350, 461]",figure_inner_text,0.9,"[""panel label / figure inner text: (a)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +31,3,chart,,"[151, 455, 445, 827]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +31,4,figure_title,(b),"[629, 419, 675, 460]",figure_inner_text,0.9,"[""panel label / figure inner text: (b)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +31,5,chart,,"[466, 457, 760, 828]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +31,6,figure_title,(c),"[937, 420, 980, 461]",figure_inner_text,0.9,"[""panel label / figure inner text: (c)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +31,7,chart,,"[781, 452, 1072, 817]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +31,8,figure_title,"Figure 12. Lipid profile after treatment with terpolymers in diabetic rats. Terpolymers were administered systemically to diabetic and normal rats as explained in methods, serum was collected to measu","[136, 872, 1086, 1119]",figure_caption_candidate,0.92,"[""figure_title label: Figure 12. Lipid profile after treatment with terpolymers in""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +31,9,text,"Heart tissues stained with Haematoxylin and Eosin (H&E) as seen Figure 13a show an intact, prominent and centrally located nuclei and normal cell size in control animals. Whereas in diabetic rats (Fig","[137, 1203, 1087, 1398]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +31,10,number,30,"[1053, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +32,0,header,Journal Pre-proof,"[494, 68, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p32 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +32,1,text,"injury due to oxidative stress. Interestingly, systemic treatment with terpolymers restored the myofibril cellular organization (Figure 13c, d, and e). ES-37 treated group showed more pronounced effec","[138, 147, 1088, 506]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +32,2,figure_title,a),"[152, 619, 186, 649]",figure_inner_text,0.9,"[""panel label / figure inner text: a)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +32,3,image,,"[146, 609, 313, 782]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +32,4,figure_title,b),"[339, 612, 373, 645]",figure_inner_text,0.9,"[""panel label / figure inner text: b)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +32,5,image,,"[332, 609, 502, 780]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +32,6,figure_title,c),"[525, 615, 558, 647]",figure_inner_text,0.9,"[""panel label / figure inner text: c)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +32,7,image,,"[517, 605, 688, 776]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +32,8,figure_title,d),"[717, 612, 750, 645]",figure_inner_text,0.9,"[""panel label / figure inner text: d)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +32,9,image,,"[705, 604, 873, 775]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +32,10,figure_title,e),"[903, 614, 934, 646]",figure_inner_text,0.9,"[""panel label / figure inner text: e)""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +32,11,image,,"[890, 605, 1060, 776]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +32,12,figure_title,Figure 13. Photomicrographs showing longitudinal section of cardiac tissues after treatment with terpolymers in (a) normal (b) alloxan (c) alloxan + ES-37 (d) alloxan + L-37 and (e) alloxan + ES-19 tr,"[132, 818, 1086, 1188]",figure_caption_candidate,0.92,"[""figure_title label: Figure 13. Photomicrographs showing longitudinal section of ""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False +32,13,number,31,"[1053, 1460, 1081, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +33,0,header,Journal Pre-proof,"[494, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p33 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +33,1,paragraph_title,CONCLUSIONS,"[140, 216, 324, 242]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSIONS""]",section_heading,0.9,tail_nonref_hold_zone,heading_like,canonical_section_name,True,True +33,2,text,"We herein report synthesis and structural characterization of TANI-based electroactive terpolymers by FTIR, $ ^{1} $H NMR, $ ^{13} $C NMR and GPC techniques. These unique terpolymers showed strong e","[137, 289, 1087, 596]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +33,3,text,"As a proof-of-principle, the antioxidant behavior of these terpolymers was evaluated in oxidatively stressed disease model of diabetic rats with high ROS levels. The systemic treatment with terpolymer","[137, 636, 1088, 1163]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +33,4,number,32,"[1054, 1460, 1083, 1483]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +34,0,header,Journal Pre-proof,"[494, 67, 729, 97]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p34 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +34,1,image,,"[160, 188, 950, 589]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +34,2,figure_title,Figure 14. Schematic diagram showing synthesis and characterization of electroactive and biodegradable tetra(aniline)TANI-based intrinsic antioxidant terpolymers (in fully reduced LEB state and doped ,"[135, 621, 1088, 1207]",figure_caption,0.92,"[""figure_title label: Figure 14. Schematic diagram showing synthesis and character""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,True,True +34,3,number,33,"[1053, 1460, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +35,0,header,Journal Pre-proof,"[494, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p35 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +35,1,paragraph_title,DATA AVAILABILITY,"[140, 145, 399, 171]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: DATA AVAILABILITY""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +35,2,text,"All data supporting the findings of this study are available within the article and its supporting information, or from the corresponding author upon request.","[137, 201, 1051, 285]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,3,paragraph_title,Declaration of Competing Interest,"[140, 398, 487, 423]",backmatter_heading,0.5,"[""backmatter boundary candidate: Declaration of Competing Interest""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True +35,4,text,The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.,"[139, 427, 1043, 503]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,5,paragraph_title,ACKNOWLEDGEMENTS,"[140, 532, 430, 558]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGEMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True +35,6,text,"Authors highly thank the Karolinska Institutet, Stockholm Sweden., Luleå University of Technology, Luleå, Sweden., higher education commission of Pakistan and Quaid-i-Azam University, Islamabad, Pakis","[137, 604, 1086, 798]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,7,paragraph_title,Conflicts of interest,"[140, 841, 349, 867]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflicts of interest""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +35,8,text,The authors declare no conflicts of interest.,"[140, 898, 561, 925]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,9,paragraph_title,Contributions,"[140, 988, 292, 1014]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Contributions""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +35,10,text,"I.M., $ {}^{a} $ Z.A., and F.Z., conceived the project, I.M, $ {}^{a} $ I.M., $ {}^{b} $ I.M., Z.A., S.Q., S.A., B.M., B.T.M., J.N.K., F.S, and F.Z., performed experiments, interpreted the findings","[138, 1050, 1071, 1107]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,11,paragraph_title,REFERENCES,"[140, 1190, 308, 1216]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +35,12,reference_content,"1. 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Journal of Experimental Nanoscience 2013;8:84-102.","[140, 415, 1082, 465]",reference_item,0.85,"[""reference content label: 65. Deepshikha, Basu T. Synthesis and characterisation of na""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,7,reference_content,"66. Haidara MA, Yassin HZ, Rateb M, Ammar H, Zorkani MA. Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Current vascular pharmacology 2006;4:215-27.","[140, 469, 1082, 520]",reference_item,0.85,"[""reference content label: 66. Haidara MA, Yassin HZ, Rateb M, Ammar H, Zorkani MA. Rol""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,8,reference_content,"67. Wang X, Tao L, Hai CX. Redox-regulating role of insulin: the essence of insulin effect. Mol Cell Endocrinol 2012;349:111-27.","[141, 523, 1082, 572]",reference_item,0.85,"[""reference content label: 67. Wang X, Tao L, Hai CX. 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Glutathione Synthe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,11,reference_content,70. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.,"[140, 738, 1058, 762]",reference_item,0.85,"[""reference content label: 70. Droge W. Free radicals in the physiological control of c""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,12,reference_content,"71. Fiory F, Parrillo L, Raciti GA, et al. PED/PEA-15 Inhibits Hydrogen Peroxide-Induced Apoptosis in Ins-1E Pancreatic Beta-Cells via PLD-1. Plos One 2014;9.","[141, 766, 1083, 814]",reference_item,0.85,"[""reference content label: 71. Fiory F, Parrillo L, Raciti GA, et al. PED/PEA-15 Inhibi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,13,reference_content,"72. Xie M, Wang L, Ge J, Guo B, Ma PX. Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering. ACS applied mat","[140, 818, 1082, 895]",reference_item,0.85,"[""reference content label: 72. Xie M, Wang L, Ge J, Guo B, Ma PX. Strong electroactive ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,14,reference_content,"73. Nanke Y, Kotake S, Akama H, Kamatani N. Alkaline phosphatase in rheumatoid arthritis patients: Possible contribution of bone-type ALP to the raised activities of ALP in rheumatoid arthritis patien","[139, 899, 1081, 975]",reference_item,0.85,"[""reference content label: 73. Nanke Y, Kotake S, Akama H, Kamatani N. Alkaline phospha""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,15,reference_content,"74. Chen SCC, Tsai SP, Jhao JY, Jiang WK, Tsao CK, Chang LY. Liver Fat, Hepatic Enzymes, Alkaline Phosphatase and the Risk of Incident Type 2 Diabetes: A Prospective Study of 132,377 Adults. Sci Rep-U","[140, 979, 1082, 1054]",reference_item,0.85,"[""reference content label: 74. Chen SCC, Tsai SP, Jhao JY, Jiang WK, Tsao CK, Chang LY.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,16,reference_content,"75. Akkiraju H, Nohe A. Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration. J Dev Biol 2015;3:177-92.","[140, 1060, 1081, 1110]",reference_item,0.85,"[""reference content label: 75. Akkiraju H, Nohe A. Role of Chondrocytes in Cartilage Fo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,17,reference_content,"76. Zhou X, von der Mark K, Henry S, Norton W, Adams H, de Crombrugghe B. Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healin","[141, 1114, 1082, 1190]",reference_item,0.85,"[""reference content label: 76. Zhou X, von der Mark K, Henry S, Norton W, Adams H, de C""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,18,reference_content,"77. Smeriglio P, Lai JH, Yang F, Bhutani N. 3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation. J Vis Exp 2015.","[141, 1194, 1081, 1244]",reference_item,0.85,"[""reference content label: 77. Smeriglio P, Lai JH, Yang F, Bhutani N. 3D Hydrogel Scaf""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,19,reference_content,"78. Zaman F, Chrysis D, Huntjens K, Fadeel B, Savendahl L. Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. 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Zaman F, Zhao Y, Celvin B, et al. Humanin is a novel reg""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +39,22,number,38,"[1053, 1461, 1083, 1484]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +40,0,header,Journal Pre-proof,"[494, 68, 729, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p40 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +40,1,reference_content,"81. Pushparaj P, Tan CH, Tan BKH. Effects of Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin-diabetic rats. J Ethnopharmacol 2000;72:69-76.","[140, 147, 1081, 196]",reference_item,0.85,"[""reference content label: 81. Pushparaj P, Tan CH, Tan BKH. Effects of Averrhoa bilimb""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,2,reference_content,82. Bray TM. Dietary antioxidants and assessment of oxidative stress. Nutrition 2000;16:578-81.,"[140, 200, 1041, 224]",reference_item,0.85,"[""reference content label: 82. Bray TM. Dietary antioxidants and assessment of oxidativ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,3,reference_content,"83. Bhaskar A, Kumar A. Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedici","[140, 227, 1082, 303]",reference_item,0.85,"[""reference content label: 83. Bhaskar A, Kumar A. Antihyperglycemic, antioxidant and h""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,4,reference_content,"84. Rosa EVC, Valgas C, Souza-Sierra MM, Corrëa AX, Radetski CM. Biomass growth, micronucleus induction, and antioxidant stress enzyme responses in Vicia faba exposed to cadmium in solution. Environme","[140, 308, 1081, 385]",reference_item,0.85,"[""reference content label: 84. Rosa EVC, Valgas C, Souza-Sierra MM, Corr\u00eba AX, Radetski""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,5,reference_content,"85. Ayyasamy R, Leelavinothan P. Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats. Pharmaceutical biology 2016;54:2521-7.","[141, 388, 1082, 439]",reference_item,0.85,"[""reference content label: 85. Ayyasamy R, Leelavinothan P. Myrtenal alleviates hypergl""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,6,reference_content,"86. Babukumar S, Vinothkumar V, Sankaranarayanan C, Srinivasan S. Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin","[141, 442, 1082, 519]",reference_item,0.85,"[""reference content label: 86. Babukumar S, Vinothkumar V, Sankaranarayanan C, Srinivas""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,7,reference_content,"87. Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circulation research 2010;107:1058-70.","[141, 523, 1081, 572]",reference_item,0.85,"[""reference content label: 87. Giacco F, Brownlee M. Oxidative stress and diabetic comp""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,8,reference_content,88. Shen GX. Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase. Can J Physiol Pharm 2010;88:241-8.,"[141, 576, 1081, 626]",reference_item,0.85,"[""reference content label: 88. Shen GX. Oxidative stress and diabetic cardiovascular di""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,9,reference_content,"89. Folli F, Corradi D, Fanti P, et al. The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro-and macrovascular complications: avenues for a mechanistic-based therapeutic ","[141, 630, 1082, 707]",reference_item,0.85,"[""reference content label: 89. Folli F, Corradi D, Fanti P, et al. The role of oxidativ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,10,reference_content,"90. Fang WJ, Wang CJ, He Y, Zhou YL, Peng XD, Liu SK. Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1 alpha deacetylation. Acta Pharmacol Sin 2","[141, 711, 1083, 789]",reference_item,0.85,"[""reference content label: 90. Fang WJ, Wang CJ, He Y, Zhou YL, Peng XD, Liu SK. Resver""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +40,11,number,39,"[1053, 1460, 1083, 1483]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +41,0,header,Journal Pre-proof,"[494, 67, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p41 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +41,1,paragraph_title,Supporting Information,"[452, 466, 772, 501]",backmatter_boundary_candidate,0.5,"[""backmatter boundary candidate: Supporting Information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True +41,2,text,Electroactive and Biocompatible Tetra(aniline)-Based Terpolymers as Intrinsic Antioxidant Drugs in Oxidative Stressed Diabetic Rats,"[138, 546, 1084, 633]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +41,3,chart,,"[147, 676, 574, 1097]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,4,chart,,"[599, 679, 1039, 1093]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,5,figure_title,"Figure S1. $ ^{13} $C NMR spectra (a) P-37, (b) L-37.","[138, 1147, 606, 1178]",figure_caption_candidate,0.85,"[""figure_title label: Figure S1. $ ^{13} $C NMR spectra (a) P-37, (b) L-37.""]",figure_caption,0.85,,legend_like,none,False,False +41,6,number,40,"[1053, 1459, 1083, 1485]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +42,0,header,Journal Pre-proof,"[494, 67, 729, 97]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p42 y=67/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +42,1,figure_title,Table S1. 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image""]",media_asset,0.85,post_reference_backmatter_zone,unknown_like,empty,True,True +43,3,number,42,"[1053, 1459, 1084, 1485]",backmatter_body,0.9,"[""page number label""]",noise,0.9,post_reference_backmatter_zone,unknown_like,short_fragment,True,True +44,0,header,Journal Pre-proof,"[494, 68, 728, 96]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p44 y=68/1584""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +44,1,paragraph_title,Highlights,"[140, 149, 279, 183]",backmatter_body,0.7,"[""structured insert label: highlights""]",structured_insert_candidate,0.7,post_reference_backmatter_zone,heading_like,short_fragment,True,True +44,2,text,"- Novel class of electroactive tetra(aniline)-based terpolymers which are not only biocompatible, tuneable and biodegradable but also possess good thermal stability and aqueous solubility.","[140, 262, 1084, 343]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,post_reference_backmatter_zone,unknown_like,none,True,True +44,3,text,• The tested terpolymers showed high antioxidative activity in diabetic rats.,"[140, 345, 900, 370]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,post_reference_backmatter_zone,unknown_like,none,True,True +44,4,text,- These terpolymers present a new strategy for the development of tuneable antioxidants.,"[140, 373, 1029, 400]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,post_reference_backmatter_zone,unknown_like,none,True,True +44,5,number,43,"[1053, 1460, 1084, 1484]",backmatter_body,0.9,"[""page number label""]",noise,0.9,post_reference_backmatter_zone,unknown_like,short_fragment,True,True diff --git a/tests/fixtures/ocr_real_papers/SAN9AYVR/block_trace.csv b/tests/fixtures/ocr_real_papers/SAN9AYVR/block_trace.csv new file mode 100644 index 00000000..17d95a15 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/SAN9AYVR/block_trace.csv @@ -0,0 +1,1964 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +1,0,header,Chem Soc Rev,"[81, 104, 390, 146]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +1,1,header_image,,"[817, 43, 1109, 128]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False +1,2,text,REVIEW ARTICLE,"[96, 186, 358, 221]",authors,0.6,"[""page-1 initial-lastname author byline: REVIEW ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True +1,3,text,"View Article Online +View Journal","[900, 184, 1075, 230]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,image,,"[85, 276, 277, 309]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True +1,5,text,Cite this: DOI: 10.1039/d4cs00413b,"[81, 336, 324, 355]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Cite this: DOI: 10.1039/d4cs00413b""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,6,doc_title,"Bioelectronics for electrical stimulation: materials, devices and biomedical applications","[339, 269, 1101, 340]",paper_title,0.8,"[""page-1 zone title_zone: Bioelectronics for electrical stimulation: materials, device""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +1,7,text,"Ya Huang, †a Kuanming Yao, †a Qiang Zhang, ⑩†a Xingcan Huang, ⑩a Zhenlin Chen, a Yu Zhou ⑪b and Xinge Yu ⑪*a","[339, 360, 976, 409]",authors,0.8,"[""page-1 zone author_zone: Ya Huang, \u2020a Kuanming Yao, \u2020a Qiang Zhang, \u2469\u2020a Xingcan Huang""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +1,8,text,Received 30th April 2024,"[81, 650, 256, 670]",frontmatter_noise,0.7,"[""frontmatter noise text: Received 30th April 2024""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False +1,9,abstract,"Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and tre","[339, 437, 1110, 745]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True +1,10,text,DOI: 10.1039/d4cs00413b,"[82, 682, 262, 701]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: DOI: 10.1039/d4cs00413b""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False +1,11,text,rsc.li/chem-soc-rev,"[81, 726, 220, 745]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False 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Introduction,"[603, 790, 805, 819]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +1,13,footnote," $ ^{a} $ Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China","[80, 831, 581, 869]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $ Department of Biomedical Engineering, City Universi""]",affiliation,0.8,body_zone,body_like,affiliation_marker,True,True +1,14,footnote," $ ^{b} $ Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China. E-mail: xingeyu@cityu.edu.hk + $ ^{\dagger} $ These authors contribute","[80, 871, 587, 931]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{b} $ Department of Electronic and Computer Engineering, ""]",affiliation,0.8,body_zone,body_like,affiliation_marker,True,True +1,15,text,"Bioelectronics integrates various concepts ranging from materials science, physics, chemistry, and biology to medicine, focusing on the development and exploration of new electronic devices and techno","[601, 837, 1111, 933]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,16,image,,"[83, 991, 312, 1268]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,17,vision_footnote,Ya Huang,"[156, 1277, 242, 1299]",footnote,0.7,"[""vision_footnote label: Ya Huang""]",footnote,0.7,body_zone,body_like,short_fragment,True,True +1,18,text,Dr Ya Huang is currently a Senior Research Fellow at the Department of Biomedical Engineering of City University of Hong Kong (CityU). She received her BS degree (2015) and PhD degree (2020) in Materi,"[327, 983, 590, 1316]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +1,19,text,"p f y +and miniaturized electrostimulation devices. She has published over +40 papers in prestigious journals like Nature, Nature Electronics, Science +Advances, etc.","[79, 1317, 588, 1388]",frontmatter_noise,0.7,"[""keyword-like block: p f y\nand miniaturized electrostimulation devices. She has p""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False +1,20,image,,"[605, 985, 834, 1268]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +1,21,vision_footnote,Kuanming Yao,"[657, 1277, 783, 1299]",footnote,0.7,"[""vision_footnote label: Kuanming Yao""]",footnote,0.7,body_zone,body_like,short_fragment,True,True +1,22,text,"Kuanming Yao is currently a post-doctoral researcher in the Department of Electrical & Computer Engineering in University of California, Los Angeles (UCLA). He was a postdoc in Prof. Xinge Yu's lab in","[849, 984, 1112, 1316]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,23,text,"f +monitoring and therapeutic stimulations, and wearable haptic +interfaces. He has cumulatively published over 50 journal articles, +and is serving as first/co-first author in more than 10 papers in +jou","[598, 1318, 1109, 1436]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +1,24,footer,This journal is © The Royal Society of Chemistry 2024,"[83, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +1,25,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,0,header,Review Article,"[82, 49, 217, 71]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,1,header,View Article Online,"[991, 19, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,2,header,Chem Soc Rev,"[973, 50, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False +2,3,text,"systems. $ ^{1-3} $ One of the most important techniques in bioelectronics is electrical stimulation (ES), a versatile and powerful technique used across a broad spectrum of medical and therapeutic ap","[79, 97, 588, 482]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,4,text,"influence neural activity, facilitate muscle contraction, and +promote tissue repair and regeneration.18 This technique is +particularly valuable in fields such as neurology, where it is +used to treat c","[601, 98, 1111, 311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,5,text,"Developing bioelectronics for ES hinges on the strategic integration of electrical signals, device interfaces and design to achieve optimal performances. $ ^{11,24,25} $ The key to this process is the","[601, 313, 1111, 482]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +2,6,image,,"[84, 552, 313, 836]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +2,7,vision_footnote,Qiang Zhang,"[145, 844, 253, 867]",footnote,0.7,"[""vision_footnote label: Qiang Zhang""]",footnote,0.7,frontmatter_side_zone,support_like,short_fragment,True,True +2,8,figure_title,"Dr Qiang Zhang is a postdoctoral fellow at the Department of Biomedical Engineering, CityU. He received his PhD in Biomedical Engineering from PolyU (2022) and Bachelor of Clinical Medicine (2016) and","[327, 550, 590, 882]",non_body_insert,0.85,"[""figure_title label: Dr Qiang Zhang is a postdoctoral fellow at the Department of""]",figure_caption,0.85,,unknown_like,none,False,False +2,9,text,integrate technologies of tissue engineering and flexible electronics to promote functional tissue repair while achieving real-time disease monitoring. He has published over 40 papers in prestigious j,"[78, 885, 589, 1003]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +2,10,image,,"[606, 552, 835, 837]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,11,vision_footnote,Xingcan Huang,"[656, 845, 786, 867]",footnote,0.7,"[""vision_footnote label: Xingcan Huang""]",footnote,0.7,frontmatter_side_zone,support_like,short_fragment,True,True +2,12,figure_title,"Xingcan Huang is currently a PhD student at the Department of Biomedical Engineering, City University of Hong Kong. He received his MPhil degree and bachelor's degree from Shandong University and Qing","[849, 550, 1110, 862]",non_body_insert,0.85,"[""figure_title label: Xingcan Huang is currently a PhD student at the Department o""]",figure_caption,0.85,frontmatter_side_zone,support_like,none,False,False +2,13,image,,"[83, 1054, 312, 1341]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,14,vision_footnote,Zhenlin Chen,"[141, 1350, 255, 1369]",footnote,0.7,"[""vision_footnote label: Zhenlin Chen""]",footnote,0.7,body_zone,body_like,short_fragment,True,True +2,15,text,"Zhenlin Chen is currently a PhD candidate in Professor Xinge Yu's group at the Department of Biomedical Engineering, City University of Hong Kong. He received his BE degree from Harbin Engineering Uni","[328, 1054, 590, 1388]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +2,16,vision_footnote,and microfluidics for wearable electronics.,"[81, 1390, 389, 1412]",footnote,0.7,"[""vision_footnote label: and microfluidics for wearable electronics.""]",footnote,0.7,body_zone,body_like,none,True,True +2,17,image,,"[605, 1058, 835, 1341]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +2,18,vision_footnote,Xinge Yu,"[680, 1350, 759, 1370]",footnote,0.7,"[""vision_footnote label: Xinge Yu""]",footnote,0.7,body_zone,body_like,short_fragment,True,True +2,19,text,"Xinge Yu is the Associate Director of Institute of Digital Medicine of City University of Hong Kong, a Member of the Hong Kong Young Academy of Sciences, the recipient of RGC Research Fellow, Innovato","[849, 1054, 1112, 1388]",non_body_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +2,20,text,"12 journals. He has published 180 papers in Nature, Nature Materials, +Nature Electronics, etc. and has filed/granted 50 patents.","[601, 1390, 1107, 1437]",frontmatter_support,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_dot,True,True +2,21,footer,Chem. Soc. Rev.,"[83, 1494, 203, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +2,22,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +3,3,text,"Additionally, the bioelectronics must be capable of generating robust electrical outputs, characterized by sufficient voltage and lifespan, tailored to specific uses. A critical aspect of effective ES","[78, 95, 588, 1125]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,"At the cellular level, ES impacts the transmembrane potential (TMP), where a vital voltage differential across the cell membrane is essential for biofunctions such as communication, growth, and metabo","[78, 1125, 589, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,"Building on these biological and electrical foundational con- +cepts, bioelectronics engineered with optimal physicochemical +properties can effectively deliver ES to cells, tissues, and organs, +enhancin","[600, 98, 1111, 431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"Section 4 catalogues a diverse array of materials utilized in bioelectronics for ES, including metals, metal oxides, carbon materials, conductive polymers, semiconductors, and their hybrids. The selec","[600, 432, 1110, 647]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,7,text,"In Section 5, the focus is on ES based bioelectronics for tissue regeneration, merging biology and engineering to develop functional replacements for damaged tissues that mimic the architecture and fu","[600, 648, 1111, 838]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"Section 6 delves into neuromodulation via ES, a versatile medical technique that alters nerve activity to modulate neurological and psychiatric conditions, influencing neural circuits for symptom alle","[600, 840, 1111, 1030]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,text,"Section 7 highlights ES as an indispensable tool for bio-functional applications, effectively bridging the gap between bioelectronic systems and biological functions by delivering targeted electrical ","[600, 1031, 1110, 1149]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,10,text,"Section 8 is the conclusion and outlook with a discussion on the future directions of bioelectronics for ES. This overview emphasizes the complexity of biological behaviors and clinical scenarios, und","[600, 1150, 1111, 1294]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,11,paragraph_title,2. Cellular responses to ES,"[601, 1342, 960, 1372]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Cellular responses to ES""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +3,12,text,Cellular responses to ES bridge the gap between bioelectrical phenomena and cellular functions. A TMP voltage difference,"[600, 1388, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,13,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +3,14,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,View Article Online,"[991, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,text,"exists in all living cells, which is regulated through a delicate balance between the accumulation of various ion concentrations inside and outside the cells. $ ^{57} $ Consequently, when applying an ","[78, 97, 589, 386]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,4,paragraph_title,2.1. Effects of ES on cell behaviors,"[79, 400, 379, 423]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Effects of ES on cell behaviors""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +4,5,text,"2.1.1. Cell alignment and migration. Guided cell alignment and migration play pivotal roles in the field of regenerative medicine since they directly participate in embryonic development, tissue forma","[78, 431, 588, 913]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +4,6,text,"gradients.59,68–70 Conversely, ventricular myocytes, cardiomyocytes, +myoblasts, and osteoblasts exhibit a distinctive tendency to align +themselves parallel to the electric field vectors, which is main","[600, 97, 1111, 311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,text,"Likewise, ES affects the cell migration, $ ^{75} $ and its directional migration in response to ES is commonly referred to as electrotaxis. $ ^{76} $ It is crucial to acknowledge that the impact of ES","[598, 312, 1112, 914]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,8,image,,"[202, 968, 988, 1401]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +4,9,figure_title,Fig. 1 The molecular and cellular-level changes activated by ES.,"[79, 1414, 532, 1436]",figure_caption,0.92,"[""figure_title label: Fig. 1 The molecular and cellular-level changes activated by""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +4,10,footer,Chem. Soc. Rev.,"[82, 1493, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1493, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,0,header,Chem Soc Rev,"[82, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,3,text,"and receptors) and interactions with signal transduction pathways (e.g., Wnt/GSK3 $ \beta $/ $ \beta $-catenin and TGF $ \beta $1/ERK/NF- $ \kappa $B signaling pathways) play a pivotal role in orchest","[78, 97, 588, 215]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,4,text,"2.1.2. Cell proliferation and apoptosis. Despite widespread evidence suggesting that ES primarily boosts cell proliferation without affecting the phenotype, particularly under continuous stimulation a","[78, 218, 589, 1029]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +5,5,text,"2.1.3. Cell differentiation. ES-induced cell differentiation represents a highly promising strategy in the field of tissue engineering, as it facilitates the integration of cells with scaffolds ex viv","[78, 1031, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +5,6,text,"the osteogenic lineage rather than cartilage, which is character- +ized by increased levels of alkaline phosphatase and collagen +type I.106,107 Additionally, many studies have demonstrated that +appropr","[600, 98, 1112, 526]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,7,text,2.1.4. Cell attachment. Cell attachment has been recognized as an important factor that significantly impacts cellular behaviors and functions. The surface micro-topological morphology of 3D scaffolds,"[600, 529, 1112, 1152]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +5,8,paragraph_title,2.2. Molecular mechanisms of cellular responses to ES,"[600, 1167, 1062, 1189]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Molecular mechanisms of cellular responses to ES""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,9,text,"The underlying mechanisms that govern the cellular responses to ES are currently the focus of ongoing research. $ ^{125,126} $ Here, we summarize some critical hypotheses or views and discuss concisel","[600, 1197, 1112, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,10,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +5,11,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,1,header,View Article Online,"[990, 19, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,2,header,Chem Soc Rev,"[972, 49, 1109, 72]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,3,image,,"[230, 106, 947, 469]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +6,4,figure_title,"c. Redistribution of surface receptors, lipid rafts and actins","[337, 485, 821, 509]",figure_caption,0.85,"[""figure_title label: c. Redistribution of surface receptors, lipid rafts and acti""]",figure_caption,0.85,body_zone,legend_like,heading_roman,True,True +6,5,figure_title,"Fig. 2 Possible mechanisms of cellular responses to ES. (a) Activation of signal transduction pathways. (b) Ion flow. (c) Redistribution of surface receptors, lipid rafts and actins. (d) Enhanced ATP ","[78, 517, 1107, 559]",figure_caption,0.92,"[""figure_title label: Fig. 2 Possible mechanisms of cellular responses to ES. (a) ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +6,6,text,"subsequently induces the expression of extracellular signal-regulated kinase, p38 mitogen activated kinase, PI3 kinase, etc. $ ^{127,128} $ Depending on the specific cell types and stimulation paramet","[78, 601, 589, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,7,text,"by Leppik et al.126 and Zhao et al.129 Altogether, these putative +cellular mechanisms are intricately intertwined within a +complex but meticulously orchestrated network that trans- +forms the external ","[600, 598, 1110, 720]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,8,paragraph_title,2.3. Conventional methods to deliver ES in vitro,"[601, 736, 1010, 758]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Conventional methods to deliver ES in vitro""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +6,9,text,"In most in vitro studies, cells are cultivated in either 2D or 3D microenvironments, providing specific regimens of ES within purpose-built chambers. The conventional methods for ES delivery can be pr","[600, 768, 1111, 1315]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,10,text,"Compared with direct coupling, capacitive coupling is biologically safer for ES. $ ^{147,148} $ As illustrated in Fig. 3b, in the setup of capacitive coupling, two electrodes are placed at opposite en","[599, 1317, 1111, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,11,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,12,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,0,header,Chem Soc Rev,"[81, 49, 219, 72]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,1,header,View Article Online,"[990, 19, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,2,header,Review Article,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,3,image,,"[247, 93, 958, 482]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +7,4,figure_title,"Fig. 3 Typical ways to deliver ES for cell behavior regulation, including (a) direct coupling, (b) capacitive coupling, and (c) inducible coupling by utilization of an electromagnetic field.","[78, 500, 1107, 543]",figure_caption,0.92,"[""figure_title label: Fig. 3 Typical ways to deliver ES for cell behavior regulati""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +7,5,text,"indirect contact with the medium, this system prevents cells from being exposed to toxic electrochemical byproducts and pH fluctuations. $ ^{147} $ More importantly, the capacitive coupling system is ","[78, 575, 589, 910]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,text,"Inductive coupling is another method for in vitro ES, which commonly involves the utilization of a conductive coil positioned around the cell culture system to generate a controllable electromagnetic ","[77, 911, 589, 1246]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,7,paragraph_title,2.4. Novel platforms for manipulation of cell behaviors,"[79, 1262, 543, 1284]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Novel platforms for manipulation of cell behaviors""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +7,8,text,"The above ES devices necessitate an external power supply to connect electrodes and/or coils, for applying an electric field, which are restrained by their inherent drawbacks like bulky size, high cos","[77, 1293, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,9,text,"to take out the device and replace the old battery with a new one, +once the battery runs out of power. The potential leakage of the +battery may also lead to concerns of biosafety, since most of the +st","[600, 576, 1112, 1172]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,10,text,"The conventional cell culture platforms employed to assess the effects of ES are predominantly 2D in nature, typically established by directly seeding cells onto culture dishes. $ ^{168} $ Despite the","[599, 1173, 1112, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,11,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 481, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +7,12,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Review Article,"[82, 50, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,2,header,Chem Soc Rev,"[973, 50, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,3,image,,"[119, 102, 1076, 865]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +8,4,figure_title,Fig. 4 Novel in vitro ES platforms to regulate cell behaviors. (a) A TENG-based platform for suppressing in vitro cancer cell migration and in vivo tumor metastasis. $ ^{[151]} $ (i) Schematic illustr,"[77, 878, 1113, 1100]",figure_caption,0.92,"[""figure_title label: Fig. 4 Novel in vitro ES platforms to regulate cell behavior""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +8,5,text,"materials, $ ^{174} $ and their composites, $ ^{175-177} $ to better mimic the architectural and chemical intricacies observed in living tissues. For example, Dutta et al. fabricated a full-thickness ","[77, 1148, 589, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,text,"network.168 Currently, there is an increasing number of studies +that utilized microfluidic devices to fabricate 3D tissue models for +ES, commonly known as ‘‘tissue-on-a-chip’’.178,179 These models +off","[600, 1148, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,7,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,8,footer,This journal is © The Royal Society of Chemistry 2024,"[711, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,1,header,View Article Online,"[990, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,3,text,"effectively emulated the standard scratch assay, confirming that unidirectional electric guidance cues were better for wound closure. Furthermore, it was revealed that unidirectional ES could even res","[78, 97, 588, 455]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,text,"To achieve the desired modulation of cell behaviors, in addition to the platforms for ES delivery, comprehensive consideration of various parameters related to ES is also required. These stimulation p","[78, 457, 587, 600]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,5,paragraph_title,3. Principles of effective ES,"[80, 641, 444, 672]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Principles of effective ES""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +9,6,text,"Effective ES in bioelectronics relies on several core principles that ensure both efficacy and safety in therapeutic applications. First, the specificity of the stimulation must be finely tuned to tar","[78, 688, 588, 1096]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,7,paragraph_title,3.1. Electrode-tissue interfaces,"[80, 1119, 349, 1141]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Electrode-tissue interfaces""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +9,8,text,"Different from cells cultured in vitro, all tissues such as muscles, neurons and skin are in a complex aqueous microenvironment containing water, electrolytes, and various kinds of physical and chemic","[78, 1149, 588, 1268]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,9,text,"3.1.1. Stimulation electrode interface modelling. Taking a neurostimulator as an example, it could be viewed as an electrochemical cell that is tested using a potentiostat or galvanostat (Fig. 5a). $ ","[78, 1270, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +9,10,text,"These can be analogized to the working electrode (WE) and +counter electrode (CE) in an electrochemical cell. Although +tissues exhibit anisotropic properties that differ from those of +a salt solution, t","[601, 97, 1111, 239]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,11,text,"Considering a pair of solid metal electrodes that are brought into contact with a liquid electrolyte solution, Boehler et al. built up an equivalent circuit model for describing the electricity pathwa","[599, 241, 1111, 887]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,12,text,"As mentioned above, the interfacial impedance between bioelectronics and tissue is lower at higher frequencies, which can be beneficial for current transmission in both directions (from bioelectronics","[600, 888, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,13,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +9,14,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,Review Article,"[82, 49, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,1,header,View Article Online,"[991, 20, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,3,figure_title,a,"[182, 101, 199, 119]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,4,image,,"[185, 103, 447, 417]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,5,figure_title,b,"[450, 98, 466, 119]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,6,chart,,"[459, 100, 673, 418]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,7,figure_title,C,"[695, 101, 711, 120]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,8,chart,,"[691, 104, 986, 431]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,9,chart,,"[186, 436, 454, 706]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,10,chart,,"[453, 440, 702, 692]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,11,chart,,"[707, 457, 987, 699]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,12,figure_title,g,"[181, 708, 198, 729]",figure_inner_text,0.9,"[""panel label / figure inner text: g""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +10,13,chart,,"[171, 711, 419, 927]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,14,chart,,"[429, 700, 686, 925]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +10,15,chart,,"[727, 728, 1019, 910]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +10,16,figure_title,Fig. 5 Stimulation electrode interface modelling. (a) Principle of stimulation with a neural interface. (b) The equivalent circuit model of the electrode–tissue interface and schematic of different ch,"[77, 935, 1109, 1097]",figure_caption,0.92,"[""figure_title label: Fig. 5 Stimulation electrode interface modelling. (a) Princi""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +10,17,text,"Additionally, phase shifts in the received signal at higher frequencies can cause significant distortion and delay, necessitating a lower sampling frequency for accurate and timely sensing.","[79, 1149, 587, 1220]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,18,text,"Capacitive coupling is not the only contributor to the charge transfer. Direct faradaic currents that involve redox chemical reactions could also exist in parallel with the capacitors; thus, the inter","[79, 1222, 588, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,19,text,"multiple parallelly connected impedances. Faradaic currents +that cause electrode corrosion, changes in electrolyte composi- +tion, or gas generation at the interface should be avoided, +especially in lo","[601, 1150, 1110, 1388]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,20,text,3.1.2. Essential electrical characteristics of ES interfaces. For evaluating the electrical performance of the electrodes at,"[601, 1390, 1111, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +10,21,footer,Chem. Soc. Rev.,"[83, 1494, 203, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,22,footer,This journal is © The Royal Society of Chemistry 2024,"[711, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,3,text,"the stimulating interface, it is important to figure out what are the electrochemical activities happening there, and thus an in vitro experiment setup is needed. The immediate surrounding environment","[78, 97, 588, 575]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,4,text,"As mentioned above, EIS is one of the basic characterization methods for evaluating the performance of an electrode. The basic principle is to analyze the voltage response to the sinusoidal excitation","[78, 576, 590, 839]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,display_formula, $$ |Z|=\sqrt{\mathrm{Re}\{\underline{Z}\}^{2}+\mathrm{Im}\{\underline{Z}\}^{2}}. $$ ,"[223, 854, 443, 887]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,6,formula_number,(1),"[546, 861, 569, 884]",unknown_structural,0.2,"[""unrecognized label 'formula_number'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True +11,7,text,"The measured spectrum also has the phase shift part plotted on a linear scale. These two parts comprise the Bode plot that reflects the transfer function of the interface, which means how smoothly cha","[78, 910, 588, 1054]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,8,text,"For characterizing the charge injection performances, methods like the charge-balanced stimulation test or pulse-clamp test could be used. $ ^{8} $ To know about the characterization mechanism, we fir","[78, 1056, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,9,text,"second half (a positive pulse with the same charge amount) by +switching the polarity. The second half often has a longer dura- +tion and lower amplitude to reduce the necessary voltage excur- +sion in t","[601, 98, 1111, 479]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,10,text,"As all biological tissues contain water, we can consider it as an aqueous environment. Thus, the most common irreversible faradaic reaction that happens in all electrode-tissue interfaces is the elect","[600, 480, 1110, 575]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,11,display_formula, $$ \mathrm{2H_{2}O +2e^{-} \leftrightarrow H_{2} +2OH^{-} (reduction)} $$ ,"[696, 587, 1016, 611]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,12,display_formula, $$ 2H_{2}O\leftrightarrow O_{2}+4H^{+}+4e^{-}\left(oxidation\right) $$ ,"[704, 635, 1006, 659]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +11,13,text,"The voltage thresholds of these reactions (both reduction and oxidation) define a range within them, which is called the “water window”.¹⁸⁶ Within the water window, the charge injected won’t cause the","[600, 672, 1111, 934]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,14,text,"Additionally, faradaic reactions could also contribute to the reversible charge injection. $ ^{196,197} $ When the products of reactions stick close to the interface and are less likely to diffuse, th","[600, 936, 1110, 1175]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,15,text,"The highly reversible faradaic reactions also include those happening in conjugated polymers, where the electrostatic interactions between the electronically conductive conjugated backbone of the poly","[600, 1174, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,16,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,17,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,header,Review Article,"[81, 49, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,1,header,View Article Online,"[991, 19, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,3,text,"happen very rapidly. As a result, it appears that the absorbed ion is merely transferring charges without contributing to material or chemical changes. This pseudo-capacitance forms not only on the el","[79, 98, 587, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,text,"Apart from the above-mentioned reversible faradaic reactions, other factors also exist that could affect the charge injection behavior whether reversible or irreversible. These factors include the tem","[79, 217, 588, 407]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,text,"The CIC $ _{max} $ could be determined by a charge-balanced stimulation test as mentioned above. A current-controlled charge-balanced biphasic pulse is applied on the WE-CE circuit, where the CE is as","[79, 408, 588, 1055]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,text,"Although the charge-balanced stimulation test could reveal $ CIC_{max} $, there are still faradaic currents within the water window and their portion in the total charge transfer can't be reflected i","[78, 1056, 587, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,7,text,"many charges are slowly or cannot be recovered. Typically, the +fast recoverable charge is attributed to EDL capacitive coupling, +the slowly recoverable charge correlates to reversible faradaic +reactio","[600, 99, 1111, 287]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,8,text,"For characterizing the electrochemical active area, experimental methods such as cyclic voltammetry (CV) could be used. $ ^{200} $ The CV method is used to drive the electrode voltage (potential) to s","[599, 289, 1112, 1054]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,9,text,"CV peaks could be used to analyze how the faradaic reactions change with varying parameters such as pH, concentrations, or product diffusion. $ ^{201} $ They could also be used to estimate the increas","[600, 1056, 1112, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,10,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,1,header,View Article Online,"[990, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,3,text,"however, only superficial layers could be used for stimulation but not the whole internal surface of the bulk.","[79, 98, 587, 144]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"Compared to traditional metal electrodes, conductive polymers, such as PEDOT:PSS, show a lower bulk conductivity than metals. However, due to their ionic/electronic mixed charge transportation mechani","[78, 145, 588, 599]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,text,"3.1.3. Safety and stability guidelines. In addition to modulating performances of the electrode-tissue interface, some parameters of stimulation signals also play crucial role in safe and effective de","[78, 600, 588, 886]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +13,6,text,"Charge-balanced biphasic waveforms have been shown to reduce tissue damage compared to monophasic waveforms, highlighting the importance of managing toxic product generation. Physiological mass action","[78, 887, 588, 1173]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,text,The Shannon model of neuronal damage describes the relationship between charge density per phase (CDPP) and charge per phase (CPP) in determining the level of neuronal injury. According to Shannon's m,"[78, 1174, 588, 1319]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,8,display_formula," $$ \log(D)=k-\log(Q), $$ ","[251, 1341, 416, 1366]",unknown_structural,0.2,"[""unrecognized label 'display_formula'""]",unknown_structural,0.2,body_zone,body_like,none,False,True +13,9,text,"where D is the CDPP, Q is the CPP, and k is a constant that is derived experimentally. $ ^{205} $ This model suggests that there is a critical threshold defined by k that separates stimulation paramet","[78, 1389, 588, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,10,text,"critical threshold defined by k that separates stimulation para- +meters that lead to tissue damage from those that do not +(Fig. 5g).206 This model is important in understanding the +impact of ES on neu","[600, 98, 1110, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,11,text,"Electrodes can experience various failure modes depending on the type of material used, such as a metal or a polymer. $ ^{202} $ On one hand, metal electrodes, such as Pt, can be susceptible to corros","[600, 217, 1111, 743]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,12,text,"Electrode failure modes at the interface and substrate result from various mechanisms, including surface or bulk material degradation and issues related to adhesive bonding (Fig. 5i). $ ^{184} $ Delam","[600, 743, 1111, 1078]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,13,text,Characterizing the stability of electrodes involves a comprehensive approach that considers various factors to ensure reliable performance over time. The deposition and manufacturing technology of ele,"[600, 1079, 1111, 1365]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,14,text,"To assess stability, it is essential to conduct aging experiments that simulate long-term usage in a shorter time frame. $ ^{184} $ Elevated temperatures can accelerate reactions, providing insights i","[599, 1367, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,15,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +13,16,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,1,header,View Article Online,"[990, 19, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,3,text,"material degradation over time. The Arrhenius equation describes how the rate constant of a chemical reaction varied with temperature. Specifically, the rate constant increases exponentially as the ac","[78, 97, 588, 432]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,4,text,"When assessing performance, high-resolution imaging techniques like scanning electron microscopy (SEM) can be utilized to verify stability and surface changes post-stimulation. $ ^{213} $ Additionally","[78, 432, 589, 746]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,5,text,"performance tests due to its relevance to the ionic composition of +the extracellular fluid, complementary measurements in more +complex electrolytes may be necessary for specific applications.","[599, 97, 1111, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,paragraph_title,3.2. Stimulation parameters,"[602, 187, 846, 209]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Stimulation parameters""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,7,text,"The parameters of ES, including intensity, duration, waveforms, and frequency, require meticulous optimization to effectively trigger the desired biological responses. Careful calibration not only ens","[600, 219, 1111, 360]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,8,text,"The cathodic monophasic waveform is highly effective for stimulation (Fig. 6a(i)). It involves unidirectional current pulses, avoiding reverse current flow. $ ^{19} $ During monophasic stimulation, re","[600, 361, 1112, 747]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,9,image,,"[216, 773, 934, 1428]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +14,10,figure_title,"Fig. 6 Typical stimulation waveforms. (a) Pulsed waveform classification regarding the polarity, charge balance and interphase delay. $ ^{19} $ Adapted from ref. 19 with permission from Elsevier, copy","[78, 1393, 1107, 1436]",figure_caption,0.92,"[""figure_title label: Fig. 6 Typical stimulation waveforms. (a) Pulsed waveform cl""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +14,11,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,12,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,1,header,View Article Online,"[991, 19, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,2,header,Review Article,"[973, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,3,text,between the stimulating and reversal phases enhances the stimulation threshold and prevents suppression (Fig. 6a(iv)). Rapid charge injection during anodic reversal quickly shifts the electrode potent,"[79, 97, 587, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,4,text,Another classification method of biphasic stimulation wave-forms categorizes them into 3 different types according to their phasic symmetry. $ ^{20} $ Biphasic waveforms consist of cathodic and anodic,"[78, 217, 588, 383]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,5,text,"Biphasic symmetric waveforms (Fig. 6b(i)) consist of equal charge/phase for both positive and negative phases, ensuring charge balance of the waveform. $ ^{20} $ These waveforms typically have a leadi","[78, 384, 588, 912]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,6,paragraph_title,4. Materials and their key performances for ES based bioelectronics,"[80, 967, 437, 1061]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Materials and their key performances for ES based bioelec""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +15,7,text,"Metals, metal oxides, carbon materials, conductive polymers, semiconductors and their hybrid materials, etc. have been widely used for ES delivery. $ ^{215} $ These materials have their own distinct a","[78, 1079, 588, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,8,text,"in the selection of appropriate materials and structure design +for development of next-generation ES systems.","[600, 97, 1109, 146]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,9,paragraph_title,4.1. Electrical performances,"[602, 162, 846, 184]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.1. Electrical performances""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +15,10,text,"Electrical performances are the key characteristics essential for the development of ES electrodes, which form the electrical communication from the device to the human body. $ ^{216} $ In Section 3.1","[600, 193, 1110, 431]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,11,text,"Metals, especially noble metals like gold (Au), silver (Ag), platinum (Pt), and palladium (Pd), are the most common electrode materials for ES by virtue of their high electrical conductivity. $ ^{184,","[600, 432, 1111, 911]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,12,text,"Some metal oxides such as IrOₓ and manganese oxide (MnO₂) have emerged as promising materials for ES in recent decades owing to their high charge injection limit.¹²⁴,²⁴² These metal oxides can mitigat","[600, 911, 1111, 1292]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,13,text,Semiconductors are solid materials classified based on conductivity or resistivity and energy bands in electronics. The conductivity of semiconductors falls within the intermediate range between that ,"[599, 1294, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,14,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +15,15,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,0,header,Review Article,"[82, 49, 217, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,2,header,Chem Soc Rev,"[973, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,3,image,,"[150, 105, 687, 325]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,4,image,,"[712, 106, 1040, 323]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,5,image,,"[152, 343, 1040, 531]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +16,6,image,,"[152, 550, 381, 755]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +16,7,image,,"[385, 554, 599, 752]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +16,8,image,,"[608, 582, 803, 753]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,9,image,,"[816, 565, 1036, 753]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,10,image,,"[153, 773, 581, 964]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,11,image,,"[598, 774, 1038, 968]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +16,12,figure_title,"Fig. 7 Design principles for ES systems with desirable physicochemical and biological performances. Key properties for development of ES systems, including (a) electrical performances such as high ele","[78, 976, 1112, 1120]",figure_caption,0.92,"[""figure_title label: Fig. 7 Design principles for ES systems with desirable physi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +16,13,text,"further improved. $ ^{253} $ Recently, a molybdenum disulfide (MoS $ _2 $)-based floating-gate memory interdigital circuit, poly(3-hexylthiophene) (P3HT)-based nanofibers, and TiN-based film electrode","[79, 1148, 588, 1316]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,14,text,"Conducting polymers feature a distinct class of organic polymers with a conjugated backbone. $ ^{259,260} $ They possess outstanding electrical and optical characteristics comparable to those found in","[78, 1318, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,15,text,"resulting in the generation of positive charges along the polymer +backbone. To maintain a charge-neutral state, negatively charged +ions, commonly known as stabilizing counter ions, are doped into +the ","[599, 1149, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,16,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,17,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,1,header,View Article Online,"[990, 19, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,2,header,Review Article,"[973, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,3,image,,"[235, 107, 952, 807]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +17,4,figure_title,Fig. 8 Common electroactive materials as building blocks for ES systems.,"[80, 833, 597, 855]",figure_caption,0.92,"[""figure_title label: Fig. 8 Common electroactive materials as building blocks for""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +17,5,text,"injection limit, making them highly favorable for ES applications. In addition, it is easy to deposit PEDOT onto various substrates by electro-polymerization of a bicyclic monomer, 3,4-ethylenedioxyth","[78, 910, 588, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,6,text,"exhibits a porous structure that is highly permeable to ions, +allowing the bulk volume to contribute to electrochemically +reactive areas. It also achieves high CSC and CIC without surface +roughening, ","[600, 910, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,7,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +17,8,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,0,header,Review Article,"[82, 48, 217, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,1,header,View Article Online,"[992, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,2,figure_title,Table 1 Recent and representative electroactive materials and their key features for ES applications,"[91, 741, 114, 1432]",table_caption,0.9,"[""table prefix matched: Table 1 Recent and representative electroactive materials an""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +18,3,header,Chem Soc Rev,"[976, 20, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,4,table,
Experimental GroupInitial Glucose LevelFinal Glucose Level
Normal9798
Alloxan456478
TypesElectroactive constituentMaterial formulationElectrical propertiesMechanical propertiesOther key featuresBiomedical applicatio,"[125, 79, 1075, 1442]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +18,5,footer,Chem. Soc. Rev.,"[84, 1493, 203, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,6,footer,This journal is © The Royal Society of Chemistry 2024,"[711, 1493, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +19,0,header,Chem Soc Rev,"[83, 48, 217, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,1,header,View Article Online,"[991, 18, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,2,header,Review Article,"[973, 48, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,3,table,
Electroactive constituentMaterial formulationElectrical propertiesMechanical propertiesOther key featuresBiomedical applicationsRef,"[132, 88, 552, 1437]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True +19,4,text,"balance the electrical conductivity and modulus of the PED-OT:PSS-based hydrogel, Santhanam prepared a conductive hydrogel with an interpenetrating network by introduction of $ Ca^{2+} $-cross-linked","[601, 97, 1111, 264]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,5,text,"PANi, a conducting polymer, has attracted significant research interest and exists in three distinct oxidation states: fully oxidized, semi-oxidized, and completely reduced. The half-oxidized form is ","[601, 265, 1111, 670]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,6,text,"Melanin is a natural polymeric pigment that possesses intrinsic conductive properties and potent anti-oxidation activity. In its chemical structure, there are complex heteropolymeric structures compos","[601, 672, 1111, 1005]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,7,text,"Carbon-based materials, including graphene and its derivatives, carbon nanotubes (CNTs), and carbon fiber, have emerged as desirable conductive components for ES electrodes. $ ^{282,283} $ These mater","[601, 1007, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,8,footer,This journal is © The Royal Society of Chemistry 2024,"[83, 1493, 480, 1515]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +19,9,footer,Chem. Soc. Rev.,"[987, 1493, 1106, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,0,header,Review Article,"[82, 49, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,3,figure_title,a,"[204, 107, 221, 124]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +20,4,image,,"[202, 103, 573, 392]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,5,figure_title,b,"[587, 105, 606, 123]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +20,6,image,,"[586, 104, 991, 389]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,7,image,,"[204, 402, 619, 762]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +20,8,image,,"[635, 399, 990, 763]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,9,figure_title,e,"[207, 777, 222, 794]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +20,10,image,,"[203, 776, 415, 974]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,11,chart,,"[430, 785, 712, 971]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,12,chart,,"[709, 785, 984, 971]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,13,image,,"[207, 999, 603, 1184]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,14,image,,"[607, 1012, 786, 1173]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,15,chart,,"[789, 1016, 985, 1177]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +20,16,figure_title,"Fig. 9 Electroactive materials. (a) Mixed ionic/electronic conduction in PEDOT:PSS. $ ^{272} $ Reproduced from ref. 272 with permission from Springer Nature, copyright 2016. (b) High-performance graph","[79, 1207, 1112, 1369]",figure_caption,0.92,"[""figure_title label: Fig. 9 Electroactive materials. (a) Mixed ionic/electronic c""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +20,17,footer,Chem. Soc. Rev.,"[83, 1494, 203, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,18,footer,This journal is © The Royal Society of Chemistry 2024,"[711, 1494, 1108, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +21,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,3,text,"electrochemical properties. Their CIC reached 10.34 mC cm⁻² with an expanded CV window and a high signal-to-noise ratio, thus facilitating the measurement of neuronal activity. Such high CIC was achie","[78, 97, 588, 670]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,4,text,"MXenes, 2D transition metal carbide nanomaterials, have gained significant attention in recent years as highly promising materials for ES due to their good electrical conductivity ( $ \sim $1000 S cm ","[78, 670, 589, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,5,text,"aqueous and organic solvents, making them feasible to fabricate +robust MXene-based thin-film electrodes for multiscale ES.294","[600, 98, 1109, 144]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,6,text,"BP is another conductive dopant that has attracted much scientific interest recently. $ ^{295} $ Due to its distinctive 2D planar structure (i.e., a bilayer arrangement along the zigzag direction and ","[600, 146, 1111, 359]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,7,text,"Apart from the abovementioned electroactive materials, hybrid conducive materials have also been proposed as the ES interfaces. For instance, it is possible to realize totally reversible non-faradaic ","[597, 360, 1112, 1366]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,8,text,"To summarize, these materials exhibit favorable electrical properties for ES through appropriate modification and processing. However, practical applications require consideration of","[600, 1366, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +21,10,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,1,header,View Article Online,"[991, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,3,text,"additional characteristics such as mechanical and biological properties, which will be comprehensively discussed in the subsequent sections.","[79, 97, 587, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,4,paragraph_title,4.2. Mechanical properties,"[80, 186, 314, 208]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.2. Mechanical properties""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +22,5,text,"ES electrodes should have rigorous mechanical performances according to their specific applications. For example, as on-skin electrodes, they need to be soft and flexible to conformally contact the sk","[78, 217, 589, 671]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,6,text,"While the material composition of an ES electrode predominantly determines its mechanical properties, numerous studies have demonstrated that meticulous geometric design can effectively complement and","[78, 671, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,7,text,"where PPy is incorporated as the conductive component while silk +fibroin is for enhanced mechanical strength.102","[600, 98, 1109, 144]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,8,text,"However, these geometric designs as well as addition of different components with high mechanical performances solely enhanced the mechanical stretching of electrodes, yet they did not address the iss","[600, 143, 1112, 887]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,9,text,"It is worth mentioning that many studies have adopted finite element analysis to evaluate the distribution of interfacial mechanical strains, aiming to direct rational structural design. $ ^{310-312} ","[600, 887, 1111, 1031]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,10,paragraph_title,4.3. Adhesion performance,"[602, 1047, 839, 1069]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.3. Adhesion performance""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +22,11,text,"ES electrodes require robust interfacial integration with the target biological tissues to deliver stimulation signals reliably, which necessitates high interfacial toughness. $ ^{216,314,315} $ Curre","[600, 1079, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,12,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,13,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +23,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,1,header,View Article Online,"[990, 19, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,3,image,,"[174, 102, 1014, 662]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +23,4,chart,,"[794, 356, 1013, 502]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,5,chart,,"[797, 504, 1006, 658]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +23,6,figure_title,Fig. 10 Mechanical properties. (a) A multilayer Au/Cr-PI construction showing excellent stretchability and compressibility. $ ^{305} $ Reproduced from ref. 305 with permission from John Wiley and Sons,"[79, 674, 1108, 738]",figure_caption,0.92,"[""figure_title label: Fig. 10 Mechanical properties. (a) A multilayer Au/Cr-PI con""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +23,7,text,"and chemical bonding, the integrated device could conformally contact and stably adhere to the dynamic heart. The adhesion energy to epicardium reached $ 240 \pm 20 \, J \, m^{-2} $. Combined with th","[78, 767, 588, 910]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,8,text,"The second strategy to enhance interfacial integration with tissues involves the fabrication of diverse microstructures on electrodes, taking inspiration from natural structures such as gecko feet, $ ","[78, 911, 588, 1388]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,9,text,"Another promising strategy involves the chemical modification of the substrates or electrodes to enhance their tackiness, typically forming pressure-sensitive adhesives. Similar to the abovementioned ","[79, 1389, 589, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,10,text,"typically forming pressure-sensitive adhesives. Similar to the +abovementioned microstructure-induced ‘‘dry adhesive’’, +pressure-sensitive adhesives do not rely on chemical bonding +for adhesion. Instea","[600, 767, 1111, 1173]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,11,text,"Controllable tissue adhesiveness is of paramount importance in the development of bioelectronic interfaces. $ ^{335} $ While strong adhesion is desirable during device use, it can potentially lead to ","[600, 1174, 1111, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,12,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +23,13,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,0,header,Review Article,"[82, 49, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,2,header,Chem Soc Rev,"[973, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,3,image,,"[116, 110, 1075, 298]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,4,image,,"[116, 315, 603, 617]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +24,5,image,,"[651, 316, 937, 437]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,6,image,,"[942, 315, 1062, 435]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,7,image,,"[674, 449, 872, 613]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,8,image,,"[883, 452, 1057, 612]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,9,image,,"[118, 630, 458, 881]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +24,10,chart,,"[124, 897, 462, 1072]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,11,image,,"[479, 634, 1070, 1068]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +24,12,chart,,"[945, 896, 1064, 1052]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +24,13,figure_title,Fig. 11 Adhesion and biological properties. (a) (i) A photocurable hydrogel-based bioelectronic interface that (ii) could strongly bind to heart tissue and the electrode by complex physical and chemic,"[78, 1086, 1112, 1289]",figure_caption,0.92,"[""figure_title label: Fig. 11 Adhesion and biological properties. (a) (i) A photoc""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +24,14,paragraph_title,4.4. Biosafety and biological functions,"[80, 1318, 408, 1339]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.4. Biosafety and biological functions""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +24,15,text,"Biosafety is a critical consideration for in vivo ES, which is determined by both stimulation parameters $ ^{340} $ and device components. $ ^{341} $ As mentioned in Section 3.2.2, ES with charge imba","[79, 1340, 588, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,16,text,"uncontrollable current pulsing, and high access voltage have +been shown to induce various irreversible chemical +reactions.342 These reactions can locally disrupt the in vivo +microenvironment (e.g., in","[600, 1317, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,17,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,18,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +25,0,header,Chem Soc Rev,"[82, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,1,header,View Article Online,"[990, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,3,text,"electrode and the adjacent tissue. To prevent excessive voltage that activates these electrochemical reactions and increase the selectivity of stimulation, Flavin et al. implemented a lower stimulatio","[78, 99, 588, 547]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,4,text,"The electrode material itself can also affect the compatibility with targeted tissues. For instance, the direct and prolonged exposure of metal film electrodes to the skin can potentially result in sk","[78, 552, 588, 886]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_side_zone,body_like,none,True,True +25,5,text,"To address these biosafety concerns, a feasible approach is to integrate multiple biological functionalities into the design of electrodes, which allows for active regulation of various biological pro","[78, 888, 589, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,6,text,"betaine), are also widely utilized to modify electrode surfaces to +form anti-biofouling interfaces.326,351 By integrating these intri- +guing biofunctions, the electrodes can mitigate potential risks +a","[600, 98, 1110, 241]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,7,paragraph_title,4.5. Biodegradable/bioresorbable properties,"[602, 257, 973, 280]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.5. Biodegradable/bioresorbable properties""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +25,8,text,"Traditional implanted ES devices require surgical removal after accomplishing their therapeutic purpose. However, secondary removal surgery not only adds an additional financial burden but also carrie","[600, 289, 1111, 503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,9,text,The in vivo degradation of bioresorbable polymers involves several representative mechanisms that are of considerable importance in the controlled dissolution within the biological environment. These ,"[600, 504, 1111, 959]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,10,text,"In general, the degradation of bioresorbable synthetic polymers like polyvinyl alcohol (PVA), poly (lactic-co-glycolic acid) (PLGA), poly (L-lactic acid) (PLLA), and polycaprolactone (PCL) mainly occu","[600, 959, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +25,11,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +25,12,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,1,header,View Article Online,"[991, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,3,text,"oxidative reaction, can be used for circuits and electrodes. In addition, silicone (Si) can also serve as a viable material choice for bioresorbable devices, as it undergoes hydrolysis to silicic acid","[78, 97, 589, 483]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,4,text,"attaching onto the mechanically dynamic heart surface, while +concurrently minimizing any discernible deviations in output +voltage during mechanical deformation. In vivo experiments +demonstrated that t","[601, 97, 1111, 239]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,5,text,"To fulfill the demands of practical applications, the degradation rate of ES devices can be finely tailored by various strategies including the change in encapsulating layer thickness and modulation o","[600, 240, 1112, 482]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +26,6,image,,"[175, 543, 1012, 1300]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +26,7,chart,,"[526, 875, 771, 1075]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +26,8,chart,,"[773, 880, 994, 1070]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +26,9,figure_title,"Fig. 12 Biodegradable properties. (a) Schematic illustrations showing the representative in vivo degradation mechanisms of bioresorbable polymers, including (i) dissolution, (ii) enzymolysis, (iii) hy","[80, 1314, 1111, 1436]",figure_caption,0.92,"[""figure_title label: Fig. 12 Biodegradable properties. (a) Schematic illustration""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +26,10,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +26,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +27,0,header,Chem Soc Rev,"[82, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +27,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +27,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +27,3,text,"acid (a hydrophilic unit) to lactic acid (a hydrophobic unit) ratio in PLGA can expedite the rate of mass loss in a physiological environment. $ ^{355} $ In addition, some degradable building blocks (","[78, 97, 588, 313]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,4,paragraph_title,4.6. Other key properties,"[80, 329, 300, 352]",subsection_heading,0.85,"[""paragraph_title label with numbering: 4.6. Other key properties""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +27,5,text,"Breathability assumes a paramount role for development of bioelectronic devices, particularly for on-skin bioelectronics, as the water vapor and sweat easily accumulate at the skin-device interfaces t","[78, 361, 588, 717]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,6,text,"Over recent years, the utilization of electrospun fibers for preparation of ultrathin breathable bioelectronics with a porous structure akin to fabric or textiles has garnered growing interest. $ ^{35","[78, 720, 589, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,7,text,"thereby safeguarding the normal operation of the devices.362 It +should be emphasized that these breathable designs are highly +suitable for electrodes, energy harvesters/storage, and/or sensors; +howeve","[600, 97, 1112, 503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,8,text,"In addition to breathability, the controllable swellability of bioelectronic interfaces has also been instrumental for their performances, especially in the case of hydrogel-based bioelectronic interf","[600, 504, 1111, 909]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,9,text,"Stimuli-responsiveness represents a highly desirable and intriguing characteristic of many intelligent systems such as drug delivery platforms. $ ^{367} $ In the specific context of ES systems, this c","[600, 911, 1112, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +27,10,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +27,11,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,1,header,View Article Online,"[991, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,3,text,films were fabricated using a combination of poly(ethylene oxide) (PEO) and poly(ethylene glycol)-α-cyclodextrin inclusion complex. These films were specifically designed to possess aligned microporou,"[78, 96, 589, 338]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,4,text,"involved the utilization of inclusion complex platelets that +facilitated the permanent crosslinking of the isotropic semi- +crystalline domains of PEO through the formation of hydrogen +bonds. During th","[600, 97, 1112, 339]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +28,5,figure_title,a,"[171, 399, 191, 421]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +28,6,image,,"[166, 395, 1027, 1112]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +28,7,figure_title,b,"[171, 758, 191, 782]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +28,8,chart,,"[318, 927, 439, 1100]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +28,9,chart,,"[624, 921, 789, 1095]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +28,10,image,,"[167, 1117, 1023, 1300]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +28,11,figure_title,Fig. 13 Other key properties. (a) (i) A highly integrated breathable bioelectronic that (ii) could transport sweat via vertical and horizontal directions. $ ^{364} $ Reproduced from ref. 364 with perm,"[80, 1314, 1111, 1435]",figure_caption,0.92,"[""figure_title label: Fig. 13 Other key properties. (a) (i) A highly integrated br""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +28,12,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +28,13,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +29,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +29,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +29,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +29,3,text,"thereby disrupting the PEO crystallites. Subsequent to the contraction phase, the PEO crosslinked by the inclusion complex transitioned into an amorphous state with a high water content, transforming ","[78, 97, 588, 336]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +29,4,text,"Notably, there are many other performances (e.g., self-healing $ ^{368,369} $ or shape memory capabilities $ ^{10,53,370} $) that can be modified or armed with to further improve the application effic","[78, 336, 588, 458]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +29,5,paragraph_title,5. ES based bioelectronics for tissue engineering,"[79, 491, 560, 556]",section_heading,0.85,"[""paragraph_title label with numbering: 5. ES based bioelectronics for tissue engineering""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +29,6,text,"Tissue engineering is a multidisciplinary field that merges biology with engineering to develop functional substitutes for damaged tissues, striving to match the structure and function of healthy in v","[78, 570, 588, 887]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +29,7,paragraph_title,5.1. Skin healing,"[80, 903, 236, 925]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.1. Skin healing""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +29,8,text,"Skin, as the largest organ in the human body, serves a crucial function in safeguarding internal tissues and organs against infections and injuries. However, it also presents significant risks of dama","[78, 934, 588, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +29,9,text,"Decades ago, the theory of skin battery and the relationship +between skin wounds and endogenous electrical signals were +proposed by Barker388 and Ghadamali,389 respectively. They +believed that the ele","[600, 99, 1111, 455]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +29,10,text,"According to the differences in current models, commonly used ES methods can be categorized as either the unidirectional current (or voltage) or bidirectional current (or voltage) stimulation method. ","[600, 457, 1111, 839]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +29,11,text,"Both unidirectional and bidirectional currents have similar effects on wound healing; the working modes are largely determined by the selection of power sources for these generators, especially for th","[599, 838, 1112, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +29,12,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +29,13,footer,Chem. Soc. Rev.,"[986, 1493, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +30,0,header,Review Article,"[82, 49, 218, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +30,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +30,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +30,3,image,,"[177, 104, 599, 300]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,4,image,,"[620, 109, 1013, 300]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,5,image,,"[184, 308, 505, 504]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,6,image,,"[512, 307, 669, 498]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,7,image,,"[688, 307, 1012, 503]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,8,image,,"[177, 511, 619, 715]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +30,9,image,,"[641, 512, 1011, 767]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,10,image,,"[177, 721, 629, 976]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +30,11,image,,"[654, 798, 988, 956]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,12,image,,"[176, 987, 1014, 1209]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +30,13,figure_title,"Fig. 14 ES for skin healing. (a) ES waveforms of unidirectional current (charge-unbalanced) and bidirectional current. $ ^{381} $ Reproduced from ref. 381 with permission from John Wiley and Sons, cop","[78, 1220, 1112, 1402]",figure_caption,0.92,"[""figure_title label: Fig. 14 ES for skin healing. (a) ES waveforms of unidirectio""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +30,14,footer,Chem. Soc. Rev.,"[83, 1494, 203, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +30,15,footer,This journal is © The Royal Society of Chemistry 2024,"[711, 1494, 1108, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +31,0,header,Chem Soc Rev,"[82, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +31,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +31,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +31,3,text,the patch was composed of anode and cathode MN arrays containing glucose oxidase (GOx) and horseradish peroxidase (HRP) encapsulated in zeolite imidazolate framework-8 (ZIF-8) nanoparticles as shown i,"[78, 98, 589, 336]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +31,4,text,"Apart from the EFCs, various sen-powered ES systems utilizing nanogenerators have been fabricated. Generally, these generators are almost driven by the piezoelectric or triboelectric effect that enabl","[77, 346, 590, 1433]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +31,5,text,"both wearable electronics and stimulated wound healing devices with great biocompatibility and skin adaptability. Among them, gallium-based liquid metals have been found to be excellent candidates for","[600, 97, 1111, 623]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +31,6,text,"Although these materials combined with ES sources can accelerate cell proliferation, migration and vascular formation, these wound dressings are passive and moderately effective. They cannot actively ","[600, 625, 1112, 1436]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +31,7,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +31,8,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +32,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +32,1,header,View Article Online,"[991, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +32,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +32,3,text,stability. The combination of multiple sensors and treatments was able to monitor wound conditions more precisely and accelerate wound healing.,"[78, 98, 588, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +32,4,paragraph_title,5.2. Muscle regeneration,"[80, 187, 298, 208]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.2. Muscle regeneration""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +32,5,text,"Muscle tissues are essential elements of an organism, making up more than 50% of body mass and playing key roles in generating force, facilitating body movement, and supporting the operation of intern","[78, 219, 589, 958]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +32,6,text,"Conductive biomaterials have shown promise in enhancing the proliferation and differentiation of cells that are sensitive to electrical stimuli. $ ^{44,407,422} $ These materials are excellent candida","[78, 958, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +32,7,text,"recently, because they can be effectively delivered to inaccessible +sites for tissue regeneration.424 Jin et al. developed an electro- +active, biocompatible and injectable hydrogel, based on +phenylbora","[600, 98, 1111, 480]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +32,8,text,"In addition to materials that directly interface with muscle tissues to influence the electrical microenvironments around muscle injuries and transmit ES to target areas, bioelectronics with more func","[599, 478, 1113, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +32,9,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +32,10,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +33,0,header,Chem Soc Rev,"[82, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +33,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +33,2,header,Review Article,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +33,3,text,"that are programmed to emit bionic spikes. This approach led to a significant 73.5% reduction in the inflammatory cytokine IL-6, showcasing its potent anti-inflammatory effects in tendon regeneration.","[78, 97, 587, 191]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +33,4,text,"The heart circulates blood through the whole body via the contraction of cardiac muscles. Unfortunately, cardiac muscle tissue has limited regeneration ability after injury, often leading to the repla","[78, 193, 589, 338]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +33,5,text,"explored an innovative approach that involves incorporating Au +nanowires (AuNWs) into alginate scaffolds to electrically +enhance communication between cardiac cells in engineered +cardiac patches (Fig. ","[600, 97, 1112, 338]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +33,6,image,,"[116, 376, 1077, 1206]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +33,7,figure_title,Fig. 15 ES for muscle regeneration. (a) Injecting the hydrogel into the damaged muscle improved the tissue repair process (left). In vivo muscle-tissue conduction in the severe tissue defect model. Sc,"[78, 1216, 1112, 1435]",figure_caption,0.92,"[""figure_title label: Fig. 15 ES for muscle regeneration. (a) Injecting the hydrog""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +33,8,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +33,9,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +34,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +34,1,header,View Article Online,"[991, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +34,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +34,3,text,"engineering is the regeneration of smooth muscles, which play a crucial role in controlling gastrointestinal motility. $ ^{15,23,411} $ Wu et al. developed an innovative ES device, termed the E-bandag","[78, 97, 588, 314]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +34,4,paragraph_title,5.3. Bone regeneration,"[80, 329, 283, 351]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.3. Bone regeneration""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +34,5,text,"Bone regeneration is the process of repairing or regenerating damaged or diseased bone tissues, which are the main structural and supportive components of the human body. As one of the few tissues in ","[78, 361, 588, 838]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +34,6,text,"Similar to the in vitro stimulation platforms, according to the differences in power sources, the electrostimulators for bone regeneration could be divided into the invasive DC ESs and non-invasive st","[78, 841, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +34,7,text,"also known as capacitive electrodes or plates, to be situated on +the skin flanking the target area. The integrated power resource +produces either a stable or fluctuating electrical field within +the ta","[600, 98, 1110, 264]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +34,8,text,"For bone ES, the selection of power sources is still a matter that requires significant attention, especially for the implanted stimulators. In addition to the commonly used commercial batteries, ther","[598, 263, 1113, 1441]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +34,9,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +34,10,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +35,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +35,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +35,2,header,Review Article,"[973, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +35,3,image,,"[174, 103, 1016, 1151]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +35,4,figure_title,"Fig. 16 ES for bone regeneration. (a) Classification of ES based bone growth by the mechanism of operation and electrical energy delivery $ ^{427} $ Reproduced from ref. 427 with permission from IEEE,","[79, 1170, 1111, 1311]",figure_caption,0.92,"[""figure_title label: Fig. 16 ES for bone regeneration. (a) Classification of ES b""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +35,5,text,"electro-inspired bone tissue regeneration (Fig. 16d). $ ^{437} $ Exhibiting superior electroactivity, biocompatibility, and osteoinductivity, the CPM@MA hydrogel notably augmented cellular functionali","[79, 1364, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,6,text,"This was accomplished through the upregulation of endogenous +transforming growth factor-beta1 (TGF-b1) and the activation of +the associated TGF-b/Smad2 signaling pathway. The hydrogel,","[600, 1365, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +35,7,footer,This journal is © The Royal Society of Chemistry 2024,"[83, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +35,8,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +36,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +36,1,header,View Article Online,"[991, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +36,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +36,3,text,"when combined with ES, promoted intracellular calcium enrichment and significantly enhanced bone defect regeneration in vivo. Furthermore, as shown in Fig. 16e, Cui et al. designed an electroactive co","[78, 97, 588, 721]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +36,4,paragraph_title,5.4. Nerve regeneration,"[80, 737, 287, 758]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.4. Nerve regeneration""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +36,5,text,"Nerve injuries can cause extensive motor, sensory, and autonomic dysfunctions, severely impacting daily and professional activities. $ ^{439-441} $ The nervous system possesses regenerative capabiliti","[78, 768, 588, 1269]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +36,6,text,"Optimal nerve recovery is often hindered by factors such as chronic axotomy, chronic denervation, and slow axonal growth at surgical sites. Research has shown that low-frequency (20 Hz) ES applied aft","[78, 1269, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +36,7,text,"the regenerative effects of ES include the promotion of axonal +growth through cyclic adenosine monophosphate (cAMP), +enhancement by neurotrophic factors, and the involvement of +Schwann cells (Fig. 17a)","[600, 98, 1111, 480]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +36,8,text,"In clinical practice, a variety of advanced strategies, including precise nerve repair surgeries and pioneering bioengineering approaches like nerve guidance conduits, are employed to enhance peripher","[600, 480, 1111, 981]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +36,9,text,"NGCs are used in combination with ES to treat neural injury, providing physical support and directional guidance while enhancing nerve growth and functional recovery through ES. This combination thera","[600, 984, 1111, 1293]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +36,10,text,"Cumbersome external percutaneous wiring is an important issue for implantable ES devices because it can lead to infection risks, local discomfort, activity restrictions, and maintenance difficulties. ","[600, 1294, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +36,11,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +36,12,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +37,0,header,Chem Soc Rev,"[82, 50, 218, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +37,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +37,2,header,Review Article,"[973, 50, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +37,3,image,,"[139, 103, 497, 293]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,4,chart,,"[502, 118, 778, 287]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,5,chart,,"[772, 112, 1051, 289]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,6,image,,"[140, 307, 623, 565]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +37,7,image,,"[635, 311, 1043, 431]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,8,image,,"[633, 445, 1050, 562]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,9,image,,"[140, 575, 552, 721]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +37,10,image,,"[140, 732, 554, 890]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +37,11,image,,"[558, 577, 1046, 889]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +37,12,figure_title,"Fig. 17 ES for nerve regeneration. (a) Neurons and Schwann cells transition into a growth state, where motoneurons display chromatolytic changes such as the nucleus shifting to an eccentric position, ","[78, 906, 1112, 1208]",figure_caption,0.92,"[""figure_title label: Fig. 17 ES for nerve regeneration. (a) Neurons and Schwann c""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +37,13,text,"circumvent these issues. Generating ES based on the piezoelectric effect of the device itself is a novel method. $ ^{452,479-481} $ Wu et al. reported a self-powered piezoelectric polymer scaffold emb","[78, 1245, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +37,14,text,"Implantation of the device improved neurological deficits in +mouse models under the stimulation of running. Expanding +upon self-powered solutions, devices based on triboelectric +nanogenerators482 or h","[600, 1243, 1111, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +37,15,footer,This journal is © The Royal Society of Chemistry 2024,"[83, 1494, 479, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +37,16,footer,Chem. Soc. Rev.,"[987, 1494, 1106, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +38,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +38,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +38,2,header,Chem Soc Rev,"[972, 49, 1109, 72]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +38,3,text,"yielded therapeutic outcomes for long-segment peripheral nerve injuries (15 mm defect) that were on par with those from autologous nerve grafts (Fig. 17b). $ ^{449} $ Moreover, tubular zinc-oxygen (Zn","[78, 97, 589, 813]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +38,4,text,"The necessity of secondary surgical interventions for the extraction of implantable devices represents a significant limitation, often resulting in patient discomfort, pain, and potential complication","[78, 814, 589, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +38,5,text,"strategy involves the utilization of battery-free electrical stimu- +lators, which are powered by external RF energy.378,486 Such +devices are fabricated using bioresorbable materials, including +Mg, Mo,","[599, 97, 1111, 527]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +38,6,paragraph_title,5.5. Drug delivery,"[602, 544, 765, 567]",subsection_heading,0.85,"[""paragraph_title label with numbering: 5.5. Drug delivery""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +38,7,text,"The field of drug delivery has experienced significant advancements, with the emergence of electric fields as a promising technique with diverse therapeutic applications. $ ^{489} $ Such applications ","[600, 575, 1111, 934]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +38,8,text,5.5.1. Iontophoresis. Iontophoresis enables the transportation of small molecules across the skin layer known as the stratum corneum via electrophoresis and electroosmosis at low-voltage (typically <1,"[599, 936, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +38,9,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +38,10,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +39,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +39,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +39,2,header,Review Article,"[973, 49, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +39,3,figure_title,a,"[207, 110, 223, 124]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,4,image,,"[204, 105, 518, 387]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,5,figure_title,b,"[525, 108, 540, 124]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,6,image,,"[524, 106, 991, 386]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,7,image,,"[204, 392, 490, 600]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,8,image,,"[497, 396, 991, 602]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,9,image,,"[204, 606, 462, 805]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,10,image,,"[462, 611, 758, 800]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +39,11,image,,"[764, 609, 992, 799]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,12,chart,,"[205, 812, 421, 907]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,13,image,,"[430, 817, 575, 907]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,14,image,,"[212, 925, 392, 1033]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,15,image,,"[420, 916, 590, 1039]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,16,image,,"[601, 814, 991, 950]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,17,image,,"[205, 1040, 589, 1183]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,18,image,,"[601, 965, 989, 1179]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +39,19,figure_title,Fig. 18 ES for drug delivery by iontophoresis. (a) The working principle of iontophoresis involves using a low electrical current to transport charged molecules on the skin's surface. $ ^{490} $ Repro,"[79, 1195, 1111, 1434]",figure_caption,0.92,"[""figure_title label: Fig. 18 ES for drug delivery by iontophoresis. (a) The worki""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +39,20,footer,This journal is © The Royal Society of Chemistry 2024,"[83, 1494, 480, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +39,21,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +40,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +40,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +40,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +40,3,text,"wound, the skin temperature increased while the resistance of the thermal resistor would decrease. As a result, the voltage on SDICH would increase and thus more antibiotics were released by iontophor","[78, 96, 589, 1031]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +40,4,text,"Subsequently, the same group applied a PENG based controllable transdermal drug delivery system for treating psoriasis. $ ^{501} $ In this study, to counter the low drug penetration resulting from ski","[78, 1031, 588, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +40,5,text,"efficiency of transdermal molecular penetration and extraction +using the MN array, as well as the potential for powering the +system with EBFCs. The results showed that the PMN was able +to lower the tran","[600, 98, 1111, 480]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +40,6,text,"Furthermore, integrated closed-loop feedback systems, which combine the strengths of sensor technologies and iontophoresis-based drug delivery techniques, have emerged as a promising strategy for adva","[600, 480, 1112, 1389]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +40,7,text,5.5.2. Electroporation. Electroporation has been one of the most commonly used strategies for non-viral drug or gene,"[601, 1390, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +40,8,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +40,9,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +41,0,header,Chem Soc Rev,"[82, 49, 219, 72]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +41,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +41,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +41,3,text,"delivery by applying high-voltage electrical pulses, which can create temporary pores or channels in the cell membrane. Electroporation can be used for various purposes, such as gene therapy, cell rep","[78, 95, 589, 1104]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +41,4,text,"As shown in Fig. 19c, high-voltage pulses were applied on the skin with pulse width on the order of microseconds to milliseconds, and a dielectric breakdown at the stratum corneum subsequently punctur","[77, 1102, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +41,5,text,"and notable stretchability was developed, comprising compo- +nents such as carbon black, graphene, silicone oil, kerosene, +and a Pt catalyst. Notably, the silicone oil additive in the +conductive ink pl","[600, 98, 1111, 360]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +41,6,text,"To further break through the skin barrier for drug delivery, MNs have been combined with the electroporation technology, which can largely improve delivery efficiency of large molecules and decrease t","[599, 359, 1112, 1223]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +41,7,paragraph_title,6. ES based bioelectronics for neuromodulation,"[601, 1261, 1000, 1325]",section_heading,0.85,"[""paragraph_title label with numbering: 6. ES based bioelectronics for neuromodulation""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +41,8,text,"Neuromodulation via ES is a promising medical technique that activates, suppresses, or modifies nerve activity with electrical impulses. $ ^{8,510} $ This approach offers hope to patients with a range","[599, 1341, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +41,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +41,10,footer,Chem. Soc. Rev.,"[986, 1493, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +42,0,header,Review Article,"[82, 49, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +42,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +42,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +42,3,image,,"[223, 101, 549, 506]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,4,figure_title,b,"[565, 112, 585, 133]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +42,5,image,,"[564, 106, 966, 328]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,6,image,,"[561, 328, 965, 507]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,7,image,,"[224, 517, 963, 887]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +42,8,image,,"[225, 898, 969, 1138]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +42,9,figure_title,Fig. 19 ES for electroporation. (a) Schematic of a bulk electroporation system. The gap between the electrodes exceeds the size of a single cell by multiple orders of magnitude. $ ^{505} $ Reproduced ,"[79, 1151, 1112, 1370]",figure_caption,0.92,"[""figure_title label: Fig. 19 ES for electroporation. (a) Schematic of a bulk elec""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +42,10,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +42,11,footer,This journal is © The Royal Society of Chemistry 2024,"[711, 1494, 1108, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +43,0,header,Chem Soc Rev,"[82, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +43,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +43,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +43,3,text,"targeted ES of nerves or specific brain regions, neuromodulation can influence neural circuits, conducive to symptom alleviation and functional restoration. $ ^{512-514} $ Brain stimulation encompasse","[78, 96, 589, 982]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +43,4,paragraph_title,6.1. Mechanisms of ES for neuromodulation,"[79, 1000, 457, 1021]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.1. Mechanisms of ES for neuromodulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +43,5,text,"The nervous system comprises numerous neurons, which are the essential units for transmitting excitatory and inhibitory signals. $ ^{536} $ Neurons are composed of several parts: the cell body (soma),","[78, 1031, 588, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +43,6,text,"ES can directly impact and modulate neural activities, either +exciting or inhibiting the neuron.539,540 Likewise, when externally +applied voltage surpasses the threshold level (rheobase), it triggers +","[600, 98, 1110, 408]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +43,7,text,"To understand how to effectively excite a neuron, researchers have developed mathematical models to quantitatively describe neuronal electrical characteristics. One model is the spatially extended non","[599, 409, 1111, 814]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +43,8,text,"From F. Rattay's computational results, the electrical signal propagation along the neuron could be intuitively visualized, where the electrical impulse (duration: 0.1 ms) is generated from both insid","[599, 816, 1112, 1439]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,citation_line,True,True +43,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +43,10,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +44,0,header,Review Article,"[82, 50, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +44,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +44,2,header,Chem Soc Rev,"[972, 50, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +44,3,figure_title,a,"[148, 103, 165, 121]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +44,4,image,,"[148, 104, 748, 325]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +44,5,figure_title,C,"[737, 103, 753, 122]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +44,6,chart,,"[752, 105, 1023, 324]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +44,7,figure_title,d,"[148, 337, 167, 358]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +44,8,figure_title,e,"[463, 340, 481, 358]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +44,9,image,,"[136, 368, 452, 590]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +44,10,chart,,"[475, 364, 723, 609]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True +44,11,chart,,"[741, 338, 1052, 607]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +44,12,figure_title,Fig. 20 Mechanism of ES on a neuron. (a) Schematic illustration of efferent neurons (left) and afferent (right) neurons and the flows of excitation. $ ^{4} $ (b) Representation and equivalent circuit ,"[79, 617, 1107, 740]",figure_caption,0.92,"[""figure_title label: Fig. 20 Mechanism of ES on a neuron. (a) Schematic illustrat""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +44,13,text,"show the $ V_n $ at the next three nodes, where a spike propagating velocity of $ \sim43 $ m s $ ^{-1} $ along the axon could be deduced.","[78, 791, 587, 837]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +44,14,text,"The concept of threshold rheobase is intricately linked to the duration of stimulation, a relationship known as the strength–duration curve (SD curve). $ ^{542} $ Using the SENN model to simulate resp","[79, 839, 588, 1318]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +44,15,paragraph_title,6.2. Electrical brain stimulation,"[79, 1334, 355, 1355]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.2. Electrical brain stimulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +44,16,text,"Electrical brain stimulation represents a cutting-edge approach for both therapeutic intervention and neurological research. $ ^{3,512,517} $ By administering precise electrical currents to designated","[79, 1366, 587, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +44,17,text,"regions, this technique can modulate neuronal activity, potentially +restoring or augmenting neural functions disrupted by +conditions.543 ES of the brain can modulate sensory processing, +modulating sen","[601, 791, 1110, 909]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +44,18,text,"6.2.1. Deep brain stimulation. DBS exerts its influence on neurotransmitter release and synaptic plasticity through a complex mechanism. $ ^{520,545,546} $ A crucial feature is that by directly suppre","[600, 912, 1111, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +44,19,text,"The outcomes of stimulating various brain areas can differ markedly. For example, targeting the area that includes the dorsal subthalamic nucleus (STN) and zona incerta (ZI) has been associated with r","[600, 1247, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +44,20,footer,Chem. Soc. Rev.,"[83, 1494, 203, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +44,21,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +45,0,header,Chem Soc Rev,"[82, 50, 218, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +45,1,header,View Article Online,"[991, 20, 1108, 35]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +45,2,header,Review Article,"[973, 49, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +45,3,image,,"[141, 101, 390, 364]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,4,image,,"[390, 102, 641, 365]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,5,table,,"[648, 104, 1047, 367]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,unknown_like,none,True,True +45,6,image,,"[141, 377, 598, 585]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +45,7,image,,"[609, 375, 1052, 583]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,8,image,,"[139, 597, 626, 797]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +45,9,image,,"[632, 601, 1052, 793]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +45,10,figure_title,"Fig. 21 Deep brain stimulation (DBS). (a) Mechanisms of DBS. Stimulation induces the release of neurotransmitters, initiating calcium waves and the subsequent release of gliotransmitters, with DBS alt","[78, 807, 1113, 1088]",figure_caption,0.92,"[""figure_title label: Fig. 21 Deep brain stimulation (DBS). (a) Mechanisms of DBS.""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +45,11,text,internal segment of the globus pallidus (GPi) are primarily targeted by DBS to mitigate symptoms of Parkinson's disease. $ ^{547} $ Both targets have been associated with similar improvements in motor,"[78, 1125, 589, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +45,12,text,"noticeable when a generalized seizure is purposefully induced +during treatment.558","[601, 1125, 1109, 1171]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +45,13,text,"In epilepsy models, ES of specific brain regions like the mammillothalamic tract (MMT) or the anterior nucleus of the thalamus (ANT) showed anti-epileptic effects, highlighting the role of DBS in modu","[600, 1174, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +45,14,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +45,15,footer,Chem. Soc. Rev.,"[987, 1494, 1106, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +46,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +46,1,header,View Article Online,"[991, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +46,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +46,3,text,"For epilepsy, DBS may decrease seizure frequency and intensity by modulating brain activity through electrode placement in the anterior nucleus of the thalamus or other specific areas. $ ^{561} $","[78, 98, 588, 168]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +46,4,text,"Moreover, DBS has been adopted to regulate mood-related behaviors by targeting specific brain regions that control emotions. Stimulating specific brain regions like the nucleus accumbens and lateral h","[77, 169, 589, 503]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +46,5,text,Different mechanisms of DBS exhibit varying time frames in terms of symptom improvement across different neurological conditions (Fig. 21c). $ ^{[521]} $ Tremor and rigidity respond almost immediately,"[78, 504, 588, 909]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_side_zone,body_like,none,True,True +46,6,text,"The left image in Fig. 21d shows a brain tissue cross-section with an electrode implant, underscoring the targeted region of this intervention for Parkinson's disease. $ ^{2} $ DBS relies on the preci","[78, 911, 589, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +46,7,text,"over the spread of the electric current is essential, along with the +ability to adjust the DBS lead’s placement as necessary, without +resorting to physical relocation.569","[600, 98, 1110, 167]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +46,8,text,"The long-term efficacy of neural probes is often hindered by mechanical mismatches and immune responses, which can lead to complications such as movement at the probe-tissue interface, glial scarring,","[600, 169, 1111, 767]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +46,9,text,"Combining deep brain stimulation with imaging methods, such as functional magnetic resonance imaging (fMRI), can be challenging due to conventional metallic electrodes causing magnetic interference an","[600, 767, 1111, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +46,10,text,"Although DBS is widely used in clinical treatments, it is often invasive, and the detailed mechanisms are not fully understood, making it almost inevitably risky and potentially accompanied by complic","[600, 1245, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +46,11,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +46,12,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +47,0,header,Chem Soc Rev,"[82, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +47,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +47,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +47,3,text,"leading to unintended consequences. Reported side effects in movement disorder treatments, such as Parkinson's disease targeting the STN, include hypomania, $ ^{580} $ depression (sometimes with psych","[77, 97, 589, 384]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +47,4,text,"Despite the high occurrence of side effects in DBS, it has been found that these incidents are related to stimulation directions and tend to occur when DBS exceeds certain thresholds, particularly in ","[78, 384, 588, 813]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +47,5,text,"6.2.2. Other electrical brain stimulation techniques. Deep brain techniques often use penetrating electrodes for brain stimulation, which can inflict brain damage. Transcranial ES (TES) applies electr","[79, 814, 589, 863]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +47,6,text,"stimulation, which can inflict brain damage. Transcranial ES +(TES) applies electrical pulses to the scalp to tune neural activity +in the brain.593 The configuration of TES generally involves +positioni","[600, 97, 1112, 622]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +47,7,text,"tDCS entails applying a steady, low-intensity electrical current to the scalp. This technique effectively modulates neuronal excitability by polarizing the underlying brain tissue. This method is favo","[599, 623, 1112, 865]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +47,8,figure_title,a,"[172, 911, 191, 932]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,9,image,,"[172, 910, 459, 1091]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,10,figure_title,b,"[460, 907, 480, 931]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,11,chart,,"[463, 908, 776, 1094]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,12,figure_title,C,"[775, 911, 794, 932]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,13,chart,,"[786, 918, 1019, 1089]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,14,figure_title,d,"[172, 1106, 193, 1132]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,15,chart,,"[209, 1111, 461, 1327]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,16,figure_title,e,"[494, 1109, 513, 1131]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +47,17,image,,"[513, 1113, 769, 1316]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,18,chart,,"[772, 1115, 1018, 1324]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +47,19,figure_title,"Fig. 22 Transcranial ES. (a) Diagram depicting the three configuration for transcutaneous (scalp), subcutaneous (skull) and epidural (dura) stimulation.⁵¹⁹ (b) Neuronal compartment orientation influen","[80, 1334, 1111, 1436]",figure_caption,0.92,"[""figure_title label: Fig. 22 Transcranial ES. (a) Diagram depicting the three con""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +47,20,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +47,21,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +48,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +48,1,header,View Article Online,"[990, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +48,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +48,3,text,"potentially altering levels of brain-derived neurotrophic factor and affecting synaptic plasticity and motor learning. Furthermore, tDCS influences gamma-aminobutyric acid (GABA) neurotransmission, en","[78, 98, 589, 240]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +48,4,text,"On the other hand, tACS applies alternating current at specific frequencies to entrain brain oscillations and modulate neural activity, aiming to synchronize with existing brain rhythms to enhance cog","[78, 242, 589, 695]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +48,5,text,"The key difference between tDCS and tACS lies in their mechanisms of action: tDCS modulates neuronal excitability through polarization, while tACS entrains endogenous brain oscillations through freque","[78, 695, 589, 958]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +48,6,text,"One critical consideration in TES is the shunting effect. The shunting effect during TES refers to the tendency of the current to divert away from the brain, following the path of least resistance, ra","[78, 959, 589, 1440]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +48,7,text,"To tackle this issue, M. Vo¨ro¨slakos and colleagues developed +an intersectional short pulse (ISP) technique that enables the +direct administration of increased current intensities into the +brain, whi","[599, 98, 1112, 598]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +48,8,text,"Compared with TES, cortical ES (CES) inserts electrodes directly on/into the cortical tissue. CES requires surgical exposure of the brain and is often used during neurosurgical procedures for brain ma","[600, 600, 1112, 1101]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +48,9,text,"Brain ES can induce sensory experiences, which are linked to the specific brain regions stimulated and the configuration of the ES. $ ^{604} $ Cortical stimulation within the somatosensory cortex has ","[598, 1102, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +48,10,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +48,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +49,0,header,Chem Soc Rev,"[82, 50, 218, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +49,1,header,View Article Online,"[991, 20, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +49,2,header,Review Article,"[973, 50, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +49,3,image,,"[177, 104, 563, 313]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +49,4,image,,"[575, 104, 1013, 314]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +49,5,image,,"[177, 324, 535, 523]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,6,image,,"[548, 325, 1017, 520]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,7,image,,"[177, 541, 438, 737]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,8,image,,"[447, 538, 700, 737]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +49,9,image,,"[717, 536, 1016, 739]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +49,10,figure_title,Fig. 23 Electronics for cortical ES. (a) Schematic depiction of a graphene-based seizure sensor and epilepsy treatment stimulation sensors. $ ^{599} $ Reproduced from ref. 599 with permission from Joh,"[78, 751, 1112, 933]",figure_caption,0.92,"[""figure_title label: Fig. 23 Electronics for cortical ES. (a) Schematic depiction""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +49,11,text,"visual cortex designed to return sight to those with complete blindness. $ ^{608} $ Each array features 43 active electrodes, alongside an electronic mechanism that is wirelessly powered to decode inc","[78, 983, 589, 1293]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +49,12,text,Traditional invasive electrode arrays for brain stimulation involve risky and invasive surgeries that may cause complications like inflammation and device failure. These methods offer high-resolution ,"[79, 1294, 589, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +49,13,text,"invasive procedures.610,611 A stent-mounted electrode array has been +shown to safely provide high-quality neural signals over extended +periods in animal models.612 Opie et al. developed a stent electr","[600, 982, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +49,14,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +49,15,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +50,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +50,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +50,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +50,3,text,"Beyond the electrodes themselves, the system for signal collection in intracortical stimulation is also crucial for ES. $ ^{535,614} $ Lee et al. unveiled a cutting-edge approach for nerve recording a","[79, 98, 589, 193]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +50,4,text,"wirelessly networked and powered microscale implants +(Fig. 23e).603 These small-scale implants are engineered to +perform neural monitoring and provide targeted ES autono- +mously. They communicate bidi","[600, 97, 1111, 193]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +50,5,figure_title,a,"[181, 242, 200, 261]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +50,6,image,,"[176, 237, 454, 361]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,7,image,,"[178, 364, 453, 485]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,8,figure_title,b,"[472, 241, 492, 263]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +50,9,image,,"[465, 238, 814, 487]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,10,image,,"[827, 237, 1014, 387]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,11,image,,"[826, 392, 1011, 486]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,12,figure_title,d,"[183, 501, 202, 522]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +50,13,image,,"[179, 496, 427, 690]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,14,figure_title,e,"[441, 499, 460, 517]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +50,15,image,,"[440, 502, 643, 678]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,16,image,,"[646, 510, 825, 677]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,17,image,,"[835, 504, 1014, 683]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,18,image,,"[177, 699, 664, 1032]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +50,19,image,,"[679, 697, 1015, 1033]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,20,figure_title,h,"[182, 1049, 200, 1071]",figure_inner_text,0.9,"[""panel label / figure inner text: h""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +50,21,image,,"[178, 1052, 496, 1398]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,22,image,,"[503, 1063, 731, 1229]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,23,image,,"[751, 1055, 998, 1231]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,24,image,,"[502, 1233, 745, 1395]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,25,image,,"[751, 1236, 996, 1394]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True +50,26,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +50,27,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +51,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +51,1,header,View Article Online,"[991, 20, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +51,2,header,Review Article,"[973, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +51,3,figure_title,Fig. 24 Spinal cord stimulation. (a) Photographs of a spinal implant and a 3D model obtained from high-resolution microcomputed tomography scans taken five weeks after the implant. (b) Reproduced from,"[81, 101, 1110, 401]",figure_caption,0.92,"[""figure_title label: Fig. 24 Spinal cord stimulation. (a) Photographs of a spinal""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +51,4,text,"hub via a 1 GHz electromagnetic link that works through the skin, enabling personalized control over each device. Research involving 48 neurograins placed on a rat's brain demonstrates this system's a","[78, 453, 588, 862]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +51,5,paragraph_title,6.3. Spinal cord stimulation,"[80, 879, 324, 901]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.3. Spinal cord stimulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +51,6,text,"ES of neural pathways in the spinal cord is facilitated by specialized electrodes designed to deliver precise electrical currents to targeted regions, thereby releasing pain, modulating neurological a","[78, 910, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +51,7,text,"Percutaneous linear-type electrodes are thin, flexible leads +that are inserted transdermally into the epidural space that +encases the spinal cord.624,628 These electrodes have multiple +contact points ","[600, 453, 1112, 1146]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +51,8,text,"The linear type is simpler to implant but tends to be less effective and more susceptible to shifting within the body. In contrast, the paddle-type provides more precise targeting and greater stabilit","[600, 1148, 1112, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +51,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +51,10,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +52,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +52,1,header,View Article Online,"[991, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +52,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +52,3,text,current semi-rigid technologies. The development of a minimally invasive paddle-type SCS (MI-SCS) device that can be percutaneously implanted and then expanded in situ merges the benefits of both type,"[78, 98, 588, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,4,text,"Developed from the gate control theory introduced by Wall and Melzack in 1965, SCS has advanced as a therapeutic approach for chronic pain conditions, notably failed back surgery syndrome and various ","[78, 218, 588, 791]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,5,text,"Besides pain relieving, SCS is also used for achieving functional movements in patients with severe spinal cord injuries. $ ^{525,527,630} $ As epidural SCS can have an impact on the neural circuitry ","[78, 790, 589, 1172]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,6,text,"By stimulating the spinal cord below the level of injury, SCS aims to enhance sensory input, promote motor function, and potentially improve bladder and bowel control. $ ^{621} $ After a severe spinal","[78, 1174, 588, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,7,text,"implanted neurostimulator, a multi-electrode paddle lead, +and a robotic support system to enable a group of individuals +with chronic spinal cord injuries to regain functional abilities +as shown in Fig","[601, 97, 1110, 191]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,8,text,"Lateral lumbosacral SCS enables individuals with lower-limb amputations to perceive sensations as if they are coming from their missing foot, which helps restore somatosensory feedback, enhances balan","[600, 193, 1111, 480]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,9,text,"A major issue following SCI is the loss of voluntary bladder control, $ ^{639} $ leading to involuntary voiding and coordination problems between bladder contraction and sphincter relaxation. $ ^{640,","[600, 480, 1111, 886]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,10,text,It's important to note that spinal neural stimulation is typically considered after other conservative treatment options have been exhausted. The specific application and suitability of SCS depend on ,"[600, 887, 1111, 1103]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,11,paragraph_title,6.4. Vagus nerve and peripheral nerve stimulation,"[601, 1119, 1024, 1142]",subsection_heading,0.85,"[""paragraph_title label with numbering: 6.4. Vagus nerve and peripheral nerve stimulation""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +52,12,text,"Neuromodulation therapies, including VNS and PNS, utilize electrical impulses to control nerve activity, which can influence immune response, organ functions and muscle control, thus broadening therap","[600, 1150, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +52,13,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +52,14,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +53,0,header,Chem Soc Rev,"[82, 49, 218, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +53,1,header,View Article Online,"[991, 20, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +53,2,header,Review Article,"[973, 49, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +53,3,image,,"[139, 100, 1052, 794]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +53,4,figure_title,"Fig. 25 Vagus nerve stimulation. (a) Demonstration of the vagal circuitry that connects the central and peripheral nervous systems. $ ^{649} $ Reproduced from ref. 649, originally published by and use","[78, 803, 1112, 945]",figure_caption,0.92,"[""figure_title label: Fig. 25 Vagus nerve stimulation. (a) Demonstration of the va""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +53,5,text,"for drug-resistant epilepsy and depression in patients. $ ^{643} $ VNS plays a crucial role in autonomic regulation, making it a valuable therapeutic option for a variety of conditions, including epil","[78, 981, 588, 1148]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +53,6,text,"Vagal circuitry serves as a bidirectional communication pathway between the central and peripheral nervous systems, playing a vital role in regulating inflammation and maintaining homeostasis (Fig. 25","[78, 1150, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +53,7,text,"effects and potentially restoring autonomic balance by reducing +pro-inflammatory cytokines such as IL-6, TNFa, and IL-1b, offer- +ing potential therapeutic benefits for conditions like cardiovas- +cular d","[601, 983, 1110, 1077]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +53,8,text,"Studies have shown that VNS aids in rebalancing parasympathetic and sympathetic nervous system activities, effectively diminishing inflammation and helping to halt the progression of conditions like s","[600, 1079, 1111, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +53,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +53,10,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +54,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +54,1,header,View Article Online,"[990, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +54,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +54,3,text,"inflammation and improving gastrointestinal function in IBD, based on animal studies that show improvements in disease activity indices and inflammation markers. Sun et al. highlighted that chronic ab","[78, 97, 588, 671]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +54,4,text,"Transcutaneous VNS (tVNS) offers a promising non-invasive alternative to invasive VNS for various medical conditions. $ ^{642} $ tVNS is an affordable and straightforward technique, ideally administer","[78, 671, 588, 1173]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +54,5,text,There are some types of electrodes commonly used for vagus and peripheral nerve stimulation. $ ^{531} $ Surface electrodes are non-invasive electrodes placed on the skin surface over the targeted peri,"[78, 1173, 588, 1365]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +54,6,text,"Both the vagus nerves and peripheral nerves have a similar narrow and elongated anatomy, making them accessible for such interventions. $ ^{10} $ The contemporary implantable VNS device, like the Liva","[78, 1367, 589, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +54,7,text,"like the Livanovar stimulator, features a compact, battery-operated +stimulator, which is surgically implanted and configured to deliver +ES to the vagus nerve, typically encircling the left cervical va","[601, 97, 1111, 694]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +54,8,text,Fig. 26c addresses the challenge of designing self-rolled neural interfaces that can effectively match the complex shapes and movements of nerves. $ ^{30} $ This study presents a novel approach utiliz,"[600, 695, 1111, 958]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Fig. 26c addresses the challenge of designing self-rolled ne""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +54,9,text,"To address the issues faced by traditional bioelectronic devices, which are unsuitable for young patients with rapidly growing tissues, morphing electronics have been introduced. Liu et al. synthesize","[600, 958, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +54,10,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +54,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +55,0,header,Chem Soc Rev,"[82, 49, 218, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +55,1,header,View Article Online,"[991, 20, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +55,2,header,Review Article,"[973, 49, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +55,3,image,,"[135, 95, 1053, 903]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +55,4,figure_title,Fig. 26 Bioelectronics for vagus nerve and peripheral nerve stimulation. (a) Photomicrographs show small vagus and peripheral nerves in rats alongside a schematic detailing how the flexible neural cli,"[78, 912, 1113, 1114]",figure_caption,0.92,"[""figure_title label: Fig. 26 Bioelectronics for vagus nerve and peripheral nerve ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +55,5,text,PNS and VNS have emerged as revolutionary approaches in the treatment of various diseases and the elicitation of sensations. By delivering targeted electrical impulses to peripheral nerves or the vagu,"[78, 1147, 589, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +55,6,text,"patients with sensory deficits. Through precise intervention, +PNS and VNS stand at the forefront of a new era in personalized +medicine, where the modulation of electrical signals in the +body can lead ","[601, 1147, 1110, 1244]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +55,7,paragraph_title,7. ES based bioelectronics for other applications,"[601, 1285, 1076, 1350]",section_heading,0.85,"[""paragraph_title label with numbering: 7. ES based bioelectronics for other applications""]",section_heading,0.85,body_zone,reference_like,reference_numeric_dot,True,True +55,8,text,"ES has become a versatile tool in biofunctional applications, offering a bridge between electronic systems and biological functions. By delivering targeted electrical impulses, this","[600, 1365, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +55,9,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +55,10,footer,Chem. Soc. Rev.,"[987, 1493, 1106, 1514]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +56,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +56,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +56,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +56,3,text,"technology can be employed to regulate heart rhythms in pacemakers, facilitate muscle rehabilitation, control acute pain, diminish tremors associated with neurological disorders, and modulate sensory ","[79, 97, 589, 217]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +56,4,text,"biological processes, thus holding the promise of +improved quality of life for individuals with various medical +conditions. This adaptability underscores the potential of ES +to revolutionize treatment","[600, 96, 1112, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +56,5,figure_title,a,"[179, 286, 197, 305]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +56,6,image,,"[175, 282, 788, 577]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,7,image,,"[802, 280, 1010, 434]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,8,image,,"[800, 443, 1005, 563]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,9,figure_title,b,"[177, 592, 194, 615]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +56,10,chart,,"[177, 597, 569, 777]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,11,figure_title,C,"[584, 594, 603, 614]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +56,12,image,,"[583, 588, 1016, 766]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,13,image,,"[185, 787, 559, 971]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,14,figure_title,d,"[585, 780, 603, 804]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,tail_nonref_hold_zone,legend_like,panel_label,True,True +56,15,image,,"[583, 778, 1017, 974]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,16,image,,"[177, 996, 1015, 1221]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +56,17,figure_title,"Fig. 27 Pacemaker. (a) This bioelectronic device is affixed to the epicardium using an adhesive hydrogel patch that enables recording of cardiac pressure and provides electrical therapy (left), which ","[79, 1236, 1112, 1435]",figure_caption,0.92,"[""figure_title label: Fig. 27 Pacemaker. (a) This bioelectronic device is affixed ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +56,18,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +56,19,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +57,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +57,1,header,View Article Online,"[991, 19, 1107, 37]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +57,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +57,3,paragraph_title,7.1. Pacemakers,"[80, 99, 230, 119]",subsection_heading,0.85,"[""paragraph_title label with numbering: 7.1. Pacemakers""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +57,4,text,"Pacemakers, through the delivery of electrical impulses to the heart muscle, have become a critical treatment for various arrhythmic conditions. They provide targeted ES to correct irregular cardiac r","[78, 128, 588, 437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +57,5,text,"Cardiomyocytes naturally produce electrical impulses that initiate in the sinoatrial node and travel through the heart's conduction system, ultimately leading to coordinated muscle contractions that p","[78, 438, 588, 769]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +57,6,text,Implantable pacemakers require materials that ensure stability and biocompatibility for long-term patient care within the body's challenging biochemical environment. Hwang et al. introduced a novel si,"[78, 770, 588, 1292]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +57,7,text,"Biodegradable pacemakers are a groundbreaking advancement in temporary cardiac pacing, removing the necessity for surgical device removal and lowering the risk of associated infections. $ ^{669,670} $","[78, 1293, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +57,8,text,"glycolic acids.671 Mg is also used, particularly for electrodes, +because of its biocompatibility and adjustable degradation rates, +ensuring that the device dissolves predictably after its therapeu- +ti","[599, 97, 1111, 311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +57,9,text,"The success of implantable pacemakers relies heavily on stable power sources, such as traditional internal batteries like lithium–iodine or lithium–silver vanadium oxide cells, which eventually requir","[599, 312, 1111, 1081]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +57,10,paragraph_title,7.2. Pain block,"[602, 1094, 743, 1117]",subsection_heading,0.85,"[""paragraph_title label with numbering: 7.2. Pain block""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +57,11,text,"Pain is a complex bodily response with both sensory and emotional components, triggered by harmful stimuli. It can manifest as acute pain, which is a direct response to injury, or chronic pain, which ","[599, 1126, 1112, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +57,12,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +57,13,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +58,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +58,1,header,View Article Online,"[991, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +58,2,header,Chem Soc Rev,"[972, 49, 1109, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +58,3,text,"by Melzack and Wall, who offered a physiological explanation for its effectiveness. $ ^{638} $ This method is widely utilized to relieve pain in various medical conditions, including labor, dysmenorrh","[78, 97, 588, 289]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +58,4,text,"TENS is a non-invasive technique that uses a portable pulse +generator and adhesive pads affixed to the skin to manage +various types of pain, with its effectiveness influenced by the +proximity of the elec","[600, 97, 1111, 290]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +58,5,image,,"[175, 362, 1015, 1242]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +58,6,figure_title,Fig. 28 Pain block. (a) Commonly targeted locations for ES used in blocking pain. $ ^{680} $ (b) Hypothesized modes of action for analgesia induced by TENS. $ ^{680} $ Adapted from ref. 680 with permi,"[78, 1252, 1111, 1435]",figure_caption,0.92,"[""figure_title label: Fig. 28 Pain block. (a) Commonly targeted locations for ES u""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +58,7,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +58,8,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +59,0,header,Chem Soc Rev,"[81, 49, 219, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +59,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +59,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +59,3,text,"impulses. (Fig. 28b) $ ^{680} $ In the segmental pain-block mechanism, TENS reduces ongoing nociceptor activity and CNS sensitization when applied to somatic receptive fields, even after spinal cord t","[77, 96, 590, 1318]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +59,4,text,"When placing TENS electrodes, ensure that they are applied to healthy, sensate skin. Position the electrodes on relevant dermatomes to direct paraesthesia into the painful area, except in cases of hyp","[78, 1317, 589, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +59,5,text,"the electrodes along the main nerves proximal to the pain, +paravertebrally at spinal segments, or at contralateral mirror +sites. For large or multiple pain areas, use dual-channel TENS +devices with fo","[600, 98, 1111, 263]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +59,6,text,Percutaneous electrical nerve stimulation (PENS) is an invasive form of pain management therapy that entails the insertion of fine needles through the skin to target specific nerve pathways directly (,"[599, 264, 1111, 1079]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +59,7,text,"Compared with PENS, invasive cuff-shaped nerve electrodes attach directly to peripheral nerves and deliver stimulation that blocks nerve conduction effectively and rapidly, usually in less than 10 ms,","[599, 1078, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +59,8,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +59,9,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +60,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +60,1,header,View Article Online,"[991, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +60,2,header,Chem Soc Rev,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +60,3,text,"electrodes were developed to avoid secondary surgical procedures for electrode removal. Lee et al. developed innovative bioabsorbable cuff-shaped electrodes for peripheral nerve stimulation, eliminati","[78, 97, 588, 408]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +60,4,text,"ES of peripheral nerves is a non-drug approach to pain management that uses low-voltage currents to activate nerve fibers, blocking pain signals to the brain and reducing pain perception. Despite thei","[78, 409, 588, 647]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +60,5,paragraph_title,7.3. Tremor reduction,"[81, 664, 277, 686]",subsection_heading,0.85,"[""paragraph_title label with numbering: 7.3. Tremor reduction""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +60,6,text,"Tremor is an involuntary, rhythmic oscillation of muscle, resulting in tremulous movement. This phenomenon is most frequently observed in the hands, although it may manifest in other parts of the body","[78, 695, 588, 1294]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +60,7,text,"Tremor reduction through peripheral ES employs two main strategies: functional ES (FES), which creates forces in tremor-producing muscles to mechanically reduce tremors, and afferent pathway stimulati","[78, 1294, 589, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +60,8,text,"management include employing FES to activate antagonistic +muscle forces, stimulating afferent fibers to decrease motor +neuron excitability, and activating cutaneous afferent fibers to +suppress interneur","[601, 97, 1111, 216]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +60,9,text,FES represents a therapeutic modality of neuromuscular ES designed to facilitate or rehabilitate functional muscle activity. This is achieved through the administration of electrical pulses at an inte,"[600, 217, 1111, 671]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +60,10,text,Afferent pathway ES offers a therapeutic strategy distinct from traditional FES by targeting sensory rather than motor pathways to alleviate tremor. This novel approach applied sub-motor-threshold ele,"[599, 672, 1112, 1078]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +60,11,text,"In addition to stimulating peripheral nerves, DBS targeting the STN is a recognized and effective treatment for managing tremors. However, its effects on complex everyday movements are not as well und","[599, 1079, 1112, 1342]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +60,12,paragraph_title,7.4. Sensory modulation,"[601, 1358, 818, 1380]",subsection_heading,0.85,"[""paragraph_title label with numbering: 7.4. Sensory modulation""]",subsection_heading,0.85,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +60,13,text,"ES, as both a therapeutic modality and an enhancement technology, introduces novel avenues for broadening the","[600, 1389, 1110, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +60,14,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +60,15,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +61,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +61,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +61,2,header,Review Article,"[973, 49, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +61,3,image,,"[178, 104, 1017, 505]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,4,image,,"[175, 511, 535, 761]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,5,image,,"[541, 515, 813, 756]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,6,image,,"[814, 516, 1016, 756]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,7,image,,"[175, 767, 531, 998]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,8,image,,"[543, 770, 1015, 1001]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +61,9,figure_title,Fig. 29 Tremor reduction. (a) The underlying mechanism by which ES can mitigate tremors involves the disruption of tremorgenic signals. (i) The signals originate from a central brain oscillator and re,"[78, 1013, 1113, 1256]",figure_caption,0.92,"[""figure_title label: Fig. 29 Tremor reduction. (a) The underlying mechanism by wh""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +61,10,text,"spectrum of human sensory experiences. This technique leverages precise electrical signals to strategically activate or modulate designated pathways within the nervous system, thereby simulating the n","[79, 1293, 589, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +61,11,text,"encompassing auditory, visual, olfactory, taste, and tactile +modalities.715,716","[600, 1293, 1109, 1339]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +61,12,text,"7.4.1. Auditory. ES has significantly advanced the field of hearing, particularly with cochlear implants, which are a groundbreaking solution for individuals with severe to profound sensorineural hear","[601, 1342, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +61,13,footer,This journal is © The Royal Society of Chemistry 2024,"[83, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +61,14,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +62,0,header,Review Article,"[82, 49, 217, 70]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +62,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +62,2,header,Chem Soc Rev,"[973, 50, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +62,3,image,,"[138, 109, 407, 344]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,4,image,,"[416, 115, 717, 337]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,5,image,,"[736, 118, 1046, 333]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,6,image,,"[143, 363, 680, 582]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,7,image,,"[692, 359, 1048, 572]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,8,image,,"[151, 595, 398, 793]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,9,image,,"[418, 595, 657, 792]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,10,image,,"[688, 584, 1044, 797]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +62,11,figure_title,"Fig. 30 Auditory, visual, smell and taste modulation by ES. (a) Auditory modulation. (i) A standard contemporary cochlear implant system transforms sound into electrical impulses, which are subsequent","[77, 812, 1113, 1195]",figure_caption,0.92,"[""figure_title label: Fig. 30 Auditory, visual, smell and taste modulation by ES. ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +62,12,text,"nonfunctional hair cells by transforming sound signals into electrical impulses that stimulate the cochlea's neural elements. This process enables sound perception in the brain, effectively restoring ","[78, 1245, 588, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +62,13,text,"and minimal interference with the surrounding tissues. Electrode +arrays are usually made of durable alloys like TiN, Ti–Ir, titanium– +tantalum, IrOx, and Pt–Ir (Fig. 30a(ii)).20,722,723 Dalrymple et a","[600, 1245, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +62,14,footer,Chem. Soc. Rev.,"[83, 1494, 204, 1513]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +62,15,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +63,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +63,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +63,2,header,Review Article,"[972, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +63,3,text,"Cochlear implantation often faces challenges such as inflammatory responses, fibrosis, and ossification, which can increase electrode impedance and disrupt neural function. $ ^{732-735} $ To reduce me","[78, 96, 589, 720]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +63,4,text,"Advancements in cochlear implant technology have included improved insertion techniques for gentler surgery, increased electrode numbers, and refined stimulation protocols. $ ^{720,741} $ However, the","[78, 719, 588, 958]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +63,5,text,"7.4.2. Vision. In visual rehabilitation, ES is a key technique in activating retinal implants that provide signals to neurons under a damaged retina, enabling basic light and shape perception for some","[78, 959, 588, 1341]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +63,6,text,Retinal implants using ES are gaining favor in clinical trials due to their ability to tap into the visual pathway's natural processing and their proven effectiveness in restoring functional vision. $,"[78, 1342, 589, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +63,7,text,"significant improvements in the daily activities and mobility of +72% of trial participants over 12 months, with 45% reporting +restored visual functions for everyday use.747 This implant +featured a mic","[600, 97, 1112, 312]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +63,8,text,Stimulating the optic nerve is an effective approach that bypasses the complex retinal structure directly targeting nerve fibers. This technique preserves the advanced information processing of later ,"[600, 312, 1111, 909]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +63,9,text,"ES has witnessed considerable advancements in the realm of vision restoration and the treatment of blindness, with mounting evidence indicating its burgeoning potential in ameliorating a spectrum of v","[600, 911, 1111, 1221]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +63,10,text,"7.4.3. Olfaction and taste. Olfaction and taste are critical chemical senses that discern chemical stimuli, aiding in survival by attracting us to nutritious foods and repelling us from dangers like t","[600, 1222, 1111, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +63,11,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1493, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +63,12,footer,Chem. Soc. Rev.,"[986, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +64,0,header,Review Article,"[81, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +64,1,header,View Article Online,"[990, 19, 1108, 37]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +64,2,header,Chem Soc Rev,"[972, 49, 1108, 72]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +64,3,text,"Electrical olfactory stimulation is an incipient technological frontier with the potential to compensate for or amplify olfactory capabilities through the application of electrical currents. $ ^{756,7","[78, 97, 588, 622]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +64,4,text,"ES is a burgeoning area of research for mimicking or restoring the sense of taste. $ ^{755,763} $ Ranasinghe et al. were at the forefront with their “Digital Lollipop,” an innovative device that simul","[78, 623, 589, 958]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +64,5,text,"7.4.4. Haptics. Tactile afferents in the hand transmit details regarding the physical properties of objects and the nature of contact during manipulation, which is critical for everyday activities. $ ","[78, 959, 589, 1340]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,heading_numbered,True,True +64,6,text,"Skin electronics and TENS are fascinating aspects of human-machine interface technology that have the capability to induce tactile sensations, effectively tricking the sense of touch. These electrodes","[78, 1341, 589, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +64,7,text,"work by delivering safe, low-level electrical currents that stimu- +late the cutaneous nerves (Fig. 31a).776 The stimulation can +mimic diverse tactile sensations, like pressure, vibration, or +even text","[599, 97, 1112, 647]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +64,8,text,"Implanted peripheral nerve interfaces could enable individuals with limb amputations to experience consistent, natural touch sensations in their phantom hands. Tan et al. designed a kind of cuff elect","[600, 648, 1112, 1102]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +64,9,text,"The development of implantable devices has long faced the issue of establishing a reliable and long-lasting method for transcutaneous communication, particularly for prosthetic limbs that require intu","[598, 1101, 1112, 1439]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +64,10,footer,Chem. Soc. Rev.,"[82, 1494, 204, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +64,11,footer,This journal is © The Royal Society of Chemistry 2024,"[710, 1494, 1108, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +65,0,header,Chem Soc Rev,"[82, 50, 218, 70]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +65,1,header,View Article Online,"[991, 20, 1108, 36]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +65,2,header,Review Article,"[973, 49, 1108, 70]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +65,3,image,,"[139, 95, 1052, 967]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True +65,4,figure_title,Fig. 31 Haptic modulation and human machine interfaces. (a) A schematic graph showing the electrotactile process where an electrode is attached on the fingertip. $ ^{776} $ Reproduced from ref. 775 wi,"[78, 985, 1112, 1206]",figure_caption,0.92,"[""figure_title label: Fig. 31 Haptic modulation and human machine interfaces. (a) ""]",figure_caption,0.92,display_zone,support_like,figure_number,True,True +65,5,text,"provides sensory feedback via neurostimulation, improving the prosthetic limb's natural sensation. This technology marks substantial progress in mimicking natural limb functionality, offering stable a","[79, 1243, 588, 1362]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +65,6,text,"An ideal prosthetic replacement should provide the user with natural-like sensations when grasping or manipulating objects, which requires the simultaneous and real-time decoding of user intent and de","[79, 1364, 588, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +65,7,text,"decoding of user intent and delivery of sensory +feedback.618,781 While peripheral nervous system neural inter- +faces have shown potential, there has been no conclusive +evidence of their effectiveness i","[600, 1243, 1111, 1435]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +65,8,footer,This journal is © The Royal Society of Chemistry 2024,"[82, 1494, 480, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +65,9,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +66,0,header,Review Article,"[82, 48, 217, 72]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +66,1,header,"View Article Online +Chem Soc Rev","[973, 19, 1109, 72]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +66,2,figure_title,Table 2 ES based bioelectronics for different biomedical applications,"[91, 944, 113, 1433]",table_caption,0.9,"[""table prefix matched: Table 2 ES based bioelectronics for different biomedical app""]",table_caption,0.9,tail_nonref_hold_zone,table_caption_like,table_number,True,True +66,3,table,
CElectrical modulationNeuroplasticityNeuronal reorganization
PDTremorRigidityAxial symptoms
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
typesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesBiomedical applicationDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
TypesDevice typeES parametersES channelsEncapsulation SizePower supplyOther properties Ref.
Long-term natural touc,"[142, 91, 510, 1431]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,none,True,True +70,5,text,"must be contracted and touch sensations felt simultaneously (Fig. 31e). $ ^{780,782} $ This sensory feedback allowed the test subject to modulate the prosthesis's grasping force accurately without rel","[602, 97, 1110, 239]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,6,text,"Advancements in ES technology are continually expanding the horizons of human sensory exploration, offering the promise of transforming our interaction with the world and enriching our quality of life","[602, 241, 1110, 409]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,7,paragraph_title,8. Conclusion and outlook,"[603, 457, 958, 485]",section_heading,0.85,"[""paragraph_title label with numbering: 8. Conclusion and outlook""]",section_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True +70,8,text,"In this review, we have explored the intricate mechanisms and diverse applications of ES and its associated bioelectronics, highlighting its profound impact on cellular behavior and potential for ther","[600, 502, 1110, 1172]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,9,text,"The future of ES is set to expand with advancements in bioelectronics, materials science, and nanotechnology. Emerging technologies are expected to enhance the precision, efficiency, and adaptability ","[602, 1173, 1110, 1389]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,10,text,"Looking ahead, future advancements in bioelectronics for ES are expected to benefit greatly from breakthroughs in","[602, 1390, 1110, 1438]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +70,11,footer,Chem. Soc. Rev.,"[84, 1493, 203, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +70,12,footer,This journal is © The Royal Society of Chemistry 2024,"[711, 1494, 1107, 1514]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False +71,0,header,Chem Soc Rev,"[82, 49, 218, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +71,1,header,View Article Online,"[991, 19, 1107, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +71,2,header,Review Article,"[973, 49, 1108, 71]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +71,3,text,"materials science. The development of biocompatible, flexible, and highly conductive materials will enhance the integration of electronic devices with biological tissues, promising higher efficiency a","[78, 97, 588, 311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,4,text,"As our understanding of the bioelectrical underpinnings of diseases advances, ES can be customized to individual physiological and pathological conditions, ushering in a new era of precision medicine.","[78, 313, 589, 551]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,5,text,The integration of ES devices with wireless technologies and the Internet of Medical Things could significantly enhance the monitoring and real-time adjustment of therapies. These systems could enable,"[78, 551, 588, 767]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +71,6,text,"As ES technologies advance and become more popular in routine clinical practices, ethical and regulatory frameworks will need to evolve accordingly. The potential for these technologies to modify neur","[78, 768, 589, 1005]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +71,7,text,"ES stands as a dynamic and versatile tool in bioelectronics, poised to make significant contributions to healthcare and medicine. By continuing to explore the complex interactions between electrical f","[78, 1007, 588, 1294]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +71,8,paragraph_title,Data availability,"[81, 1342, 289, 1372]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data availability""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True +71,9,text,This review does not include any new research data generated by the authors. All figures presented in this review are used with proper authorization from the original sources. The original sources of ,"[78, 1388, 587, 1437]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True +71,10,text,"with proper authorization from the original sources. The origi- +nal sources of all figures can be found in the corresponding +captions.","[601, 97, 1110, 169]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,11,paragraph_title,Conflicts of interest,"[602, 201, 866, 231]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Conflicts of interest""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +71,12,text,There are no conflicts to declare.,"[601, 248, 873, 271]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,13,paragraph_title,Acknowledgements,"[602, 306, 864, 335]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +71,14,text,"This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region (Grant No. RFS2324-1S03, 11213721, 11215722, and 11211523), the Innovation and Technology Fund of ","[600, 352, 1111, 617]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +71,15,paragraph_title,References,"[604, 648, 753, 678]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +71,16,reference_content,"1 J. 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Brel\u00e9, F. Duret, B. G\u00e9rard, J. Delbeke and C. Vera""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,10,reference_content,"752 Y. Yan, et al., Invest Ophthalmol. Visual Sci., 2016, 57, 6327.","[82, 337, 585, 357]",reference_item,0.85,"[""reference content label: 752 Y. Yan, et al., Invest Ophthalmol. Visual Sci., 2016, 57""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,11,reference_content,"753 J. Sun, Y. Chen, X. Chai, Q. Ren and L. Li, Graefe's Arch. Clin. Exp. Ophthalmol., 2013, 251, 2545.","[84, 362, 585, 403]",reference_item,0.85,"[""reference content label: 753 J. Sun, Y. Chen, X. Chai, Q. Ren and L. Li, Graefe's Arc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,12,reference_content,"754 Y. Lu, et al., J. Neural Eng., 2013, 10, 036022.","[83, 409, 481, 429]",reference_item,0.85,"[""reference content label: 754 Y. Lu, et al., J. 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Neurosci., 2018, 12, 225.","[84, 552, 584, 595]",reference_item,0.85,"[""reference content label: 757 A. Maharjan, E. Wang, M. Peng and Y. O. Cakmak, Front. N""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,16,reference_content,"758 T. Weiss, et al., Cereb. Cortex, 2016, 26, 4180.","[83, 600, 486, 620]",reference_item,0.85,"[""reference content label: 758 T. Weiss, et al., Cereb. Cortex, 2016, 26, 4180.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,17,reference_content,"759 T. H. Musiolik in Neuromarketing in Business: Identifying Implicit Purchase Drivers and Leveraging them for Sales, ed. B. B. Briesemeister and W. K. Selmer, Springer, Fachmedien Wiesbaden, 2022, p","[83, 624, 586, 715]",reference_item,0.85,"[""reference content label: 759 T. H. Musiolik in Neuromarketing in Business: Identifyin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,18,reference_content,"760 T. Ishimaru, et al., Chem. Senses, 1997, 22, 77.","[82, 719, 493, 740]",reference_item,0.85,"[""reference content label: 760 T. Ishimaru, et al., Chem. Senses, 1997, 22, 77.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,19,reference_content,"761 T. Ishimaru, T. Miwa, T. Shimada and M. Furukawa, Ann. Otol., Rhinol., Laryngol., 2002, 111, 518.","[83, 744, 585, 786]",reference_item,0.85,"[""reference content label: 761 T. Ishimaru, T. Miwa, T. Shimada and M. Furukawa, Ann. O""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,20,reference_content,"762 C. Yamamoto, Jpn. J. Physiol., 1961, 11, 545.","[82, 790, 476, 812]",reference_item,0.85,"[""reference content label: 762 C. Yamamoto, Jpn. J. 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Koike in Proceedings of the 6th Augmented Human International Conference 191 (Association for Computing Machinery, Singapore, Singapore, 2015).","[604, 289, 1108, 357]",reference_item,0.85,"[""reference content label: 768 Y. Aruga and T. Koike in Proceedings of the 6th Augmente""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,27,reference_content,"769 H. T. Lawless, D. A. Stevens, K. W. Chapman and A. Kurtz, Chem. Senses, 2005, 30, 185.","[604, 361, 1107, 404]",reference_item,0.85,"[""reference content label: 769 H. T. Lawless, D. A. Stevens, K. W. Chapman and A. Kurtz""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,28,reference_content,"770 K. Sakurai, K. Aoyama, M. Mizukami, T. Maeda and H. Ando in Proceedings of the 1st Workshop on Multi-sensorial Approaches to Human-Food Interaction Article 2 (Association for Computing Machinery, ","[605, 410, 1109, 499]",reference_item,0.85,"[""reference content label: 770 K. Sakurai, K. Aoyama, M. Mizukami, T. Maeda and H. Ando""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,29,reference_content,"771 K. Aoyama, et al., Front. Psychol., 2017, 8, 2112.","[604, 504, 1024, 524]",reference_item,0.85,"[""reference content label: 771 K. Aoyama, et al., Front. Psychol., 2017, 8, 2112.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,30,reference_content,"772 H. P. Saal, B. P. Delhaye, B. C. Rayhaun and S. J. Bensmaia, Proc. Natl. Acad. Sci. U. S. A., 2017, 114, E5693.","[605, 528, 1108, 571]",reference_item,0.85,"[""reference content label: 772 H. P. Saal, B. P. Delhaye, B. C. Rayhaun and S. J. 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Rob.,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,34,reference_content,"776 K. Yao, et al., Nat. Mach. Intell., 2022, 4, 893.","[604, 672, 1004, 692]",reference_item,0.85,"[""reference content label: 776 K. Yao, et al., Nat. Mach. Intell., 2022, 4, 893.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,35,reference_content,"777 L. E. Osborn, et al., Sci. Rob., 2018, 3, eaat3818.","[604, 696, 1027, 717]",reference_item,0.85,"[""reference content label: 777 L. E. Osborn, et al., Sci. Rob., 2018, 3, eaat3818.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,36,reference_content,"778 D. W. Tan, et al., Sci. Transl. Med., 2014, 6, 257ra138.","[603, 720, 1072, 740]",reference_item,0.85,"[""reference content label: 778 D. W. Tan, et al., Sci. Transl. Med., 2014, 6, 257ra138.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,37,reference_content,"779 M. Ortiz-Catalan, B. Håkansson and R. Brånemark, Sci. Transl. Med., 2014, 6, 257re6.","[604, 745, 1106, 785]",reference_item,0.85,"[""reference content label: 779 M. Ortiz-Catalan, B. H\u00e5kansson and R. Br\u00e5nemark, Sci. Tr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,38,reference_content,"780 S. Raspopovic, et al., Sci. Transl. Med., 2014, 6, 222ra19.","[603, 791, 1090, 812]",reference_item,0.85,"[""reference content label: 780 S. Raspopovic, et al., Sci. Transl. Med., 2014, 6, 222ra""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,39,reference_content,"781 G. Gu, et al., Nat. Biomed. Eng., 2023, 7, 589.","[604, 815, 1002, 836]",reference_item,0.85,"[""reference content label: 781 G. Gu, et al., Nat. Biomed. Eng., 2023, 7, 589.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,40,reference_content,"782 E. D'Anna, et al., Sci. Rob., 2019, 4, eaau8892.","[604, 839, 1011, 859]",reference_item,0.85,"[""reference content label: 782 E. D'Anna, et al., Sci. Rob., 2019, 4, eaau8892.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,41,reference_content,"783 C. Wu, et al., Adv. Funct. Mater., 2020, 30, 1907378.","[604, 863, 1054, 883]",reference_item,0.85,"[""reference content label: 783 C. Wu, et al., Adv. Funct. Mater., 2020, 30, 1907378.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True +81,42,footer,This journal is © The Royal Society of Chemistry 2024,"[83, 1494, 479, 1514]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False +81,43,footer,Chem. Soc. Rev.,"[987, 1494, 1107, 1513]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/TSCKAVIS/block_trace.csv b/tests/fixtures/ocr_real_papers/TSCKAVIS/block_trace.csv index 128562fe..02bdc773 100644 --- a/tests/fixtures/ocr_real_papers/TSCKAVIS/block_trace.csv +++ b/tests/fixtures/ocr_real_papers/TSCKAVIS/block_trace.csv @@ -3,7 +3,7 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 1,1,header,https://doi.org/10.1038/s41574-024-00969-x,"[778, 80, 1125, 105]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False 1,2,header,Check for updates,"[958, 185, 1125, 211]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False 1,3,text,Review article,"[75, 185, 216, 212]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False -1,4,doc_title,Metabolic regulation of skeletal cell fate and function,"[76, 235, 969, 375]",paper_title,0.6,"[""page-1 frontmatter title guard: Metabolic regulation of skeletal cell fate and function""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True +1,4,doc_title,Metabolic regulation of skeletal cell fate and function,"[76, 235, 969, 375]",paper_title,0.8,"[""page-1 zone title_zone: Metabolic regulation of skeletal cell fate and function""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True 1,5,paragraph_title,Steve Stegen Ⓤ & Geert Carmeliet Ⓤ ✉ Abstract,"[74, 443, 421, 505]",authors,0.6,"[""author byline on page 1, assigned as authors: Steve Stegen \u24ca & Geert Carmeliet \u24ca \u2709 Abstract""]",authors,0.6,frontmatter_main_zone,support_like,none,True,True 1,6,footer,,"[75, 480, 167, 505]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,empty,False,False 1,7,abstract,Bone development and bone remodelling during adult life are highly anabolic processes requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone-resorbing osteoclasts inte,"[73, 542, 858, 1254]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True @@ -19,9 +19,11 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 2,4,paragraph_title,Introduction,"[76, 780, 210, 803]",section_heading,0.9,"[""explicit scholarly heading: Introduction""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True 2,5,text,"The skeleton has been considered to be a metabolically active organ for decades $ ^{1-3} $. The formation of bone, and also its maintenance throughout life, rely on highly anabolic, nutrient-consuming","[73, 805, 593, 1192]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,6,text,"Technological developments have enabled scientists to thoroughly analyse cell metabolism in vitro and even in vivo. Most studies have been performed in the context of cancer biology, but more recently","[73, 1192, 593, 1386]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,7,text,,"[606, 222, 1126, 289]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +2,7,text,"information on the importance of skeletal cell metabolism for bone +and whole-body physiology. The most relevant in vivo studies for this +Review are listed in Table 1.","[606, 222, 1126, 289]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,8,text,"In this Review, we summarize the current understanding of fuel selection and intermediary metabolic pathways in bone cells during bone formation, and how metabolic dysfunction can contribute to skelet","[73, 1385, 594, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -2,9,paragraph_title,Cell types involved in skeletal development and homeostasis,"[607, 306, 1098, 352]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell types involved in skeletal development and homeostasis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +2,9,paragraph_title,Cell types involved in skeletal development and homeostasis,"[607, 306, 1098, 352]",unknown_structural,0.8,"[""page-1 zone title_zone: Cell types involved in skeletal development and homeostasis""]",paper_title,0.8,body_zone,heading_like,none,False,True 2,10,text,Skeletal development strongly depends on the differentiation and activity of phenotypically distinct cell types that are derived from different lineages. The mesenchymal lineage gives rise to bone-for,"[606, 353, 1126, 483]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,11,text,"The different mature mesenchymal cell types are not derived from a single stem cell but from a diverse set of skeletal stem and progenitor cells (SSPCs), which are found in distinct anatomical niches ","[606, 483, 1127, 675]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 2,12,text,Osteoblasts derive from all subtypes of SSPCs and typically produce a collagenous extracellular matrix that later on becomes mineralized. Most terminally differentiated osteoblasts become progressivel,"[606, 675, 1128, 1322]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True @@ -29,17 +31,19 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 2,14,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 2,15,number,400,"[1086, 1524, 1125, 1543]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 3,0,paragraph_title,Review article,"[77, 80, 308, 116]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False -3,1,figure_title,Table 1 | In vivo metabolic studies in different cell types using transgenic mouse models,"[77, 222, 815, 249]",table_caption_candidate,0.9,"[""table prefix matched: Table 1 | In vivo metabolic studies in different cell types ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +3,1,figure_title,Table 1 | In vivo metabolic studies in different cell types using transgenic mouse models,"[77, 222, 815, 249]",table_caption,0.9,"[""table prefix matched: Table 1 | In vivo metabolic studies in different cell types ""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 3,2,table,"
GeneCre driverPhenotypeCell functionMetabolismRefs.
SSPCs
Glut1Prrx1No effec","[74, 248, 1124, 1498]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 3,3,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 557, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 3,4,number,401,"[1091, 1524, 1124, 1542]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 4,0,paragraph_title,Review article,"[77, 81, 308, 117]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False -4,1,figure_title,Table 1 (continued) | In vivo metabolic studies in different cell types using transgenic mouse models,"[77, 222, 917, 248]",table_caption_candidate,0.9,"[""table prefix matched: Table 1 (continued) | In vivo metabolic studies in different""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +4,1,figure_title,Table 1 (continued) | In vivo metabolic studies in different cell types using transgenic mouse models,"[77, 222, 917, 248]",table_caption,0.9,"[""table prefix matched: Table 1 (continued) | In vivo metabolic studies in different""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True 4,2,table,"
GeneCre driverPhenotypeCell functionMetabolismRefs.
Chondrocytes (continued)
Elovl6Sy","[77, 241, 1124, 903]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True 4,3,vision_footnote,"This table summarizes the most important in vivo studies mentioned in the main text.?, mechanism is not yet fully understood; αKG, α-ketoglutarate; Ac-CoA, acetyl coenzyme A; AMPK, AMP-activated prote","[73, 905, 1083, 975]",footnote,0.7,"[""vision_footnote label: This table summarizes the most important in vivo studies men""]",footnote,0.7,body_zone,body_like,none,True,True 4,4,paragraph_title,A general overview of cell metabolism,"[75, 1017, 469, 1041]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: A general overview of cell metabolism""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 4,5,text,"Historically, most studies in the bone field focused on identifying the nutritional sources and metabolic pathways that support the synthesis of ATP. The main cellular bioenergetic hub consists of the","[73, 1041, 595, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -4,6,text,,"[606, 1019, 1127, 1214]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +4,6,text,"securing energy homeostasis in oxygen-limiting conditions. In addi- +tion, lactate production also secures the regeneration of NADH from +NAD+, which is necessary for several biosynthetic reactions21. R","[606, 1019, 1127, 1214]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,7,text,"In addition to ATP production, many other metabolic pathways produce intermediates with additional regulatory roles (Fig. 2). For example, metabolites such as citrate, α-ketoglutarate and pyruvate can","[605, 1212, 1128, 1496]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 4,8,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 4,9,number,402,"[1088, 1524, 1126, 1542]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -50,19 +54,23 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 5,4,text,"Of the different nutrients, glucose has long been considered to be the most important for SSPC function (Fig. 3), as evidenced by in vitro deprivation studies. Intriguingly, deletion of the glucose tr","[73, 675, 594, 1192]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,5,text,"Besides glucose, fatty acids are also a possible nutritional source for SSPCs, as these cells express several fatty acid oxidation (FAO)-related genes $ ^{30} $ (Fig. 3). However, carnitine palmitoylt","[73, 1192, 593, 1343]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,6,text,"Concerning amino acid metabolism, the amino acid sensor GCN2 (also known as eIF2AK4) controls the proliferation of bone marrow SSPCs and their progeny. GCN2 becomes activated when intracellular free a","[73, 1342, 594, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -5,7,text,,"[605, 223, 1125, 352]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +5,7,text,"amino acid in circulation32, is taken up by SSPCs, and its conversion to +α-ketoglutarate is important for the proliferation of cultured SSPCs33,34. +However, the in vivo deletion of the rate-limiting e","[605, 223, 1125, 352]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,8,text,The lack of an in vivo bone phenotype when important metabolic transporters or enzymes are deleted suggests that SSPCs display a high metabolic plasticity. This metabolic flexibility is probably neede,"[605, 353, 1128, 568]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,9,text,"In addition, the high metabolic plasticity of SSPCs provides strategic opportunities for tissue engineering approaches, whereby cells have to be transplanted in the avascular environment of the fractu","[605, 568, 1127, 765]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 5,10,image,,"[610, 799, 1126, 1337]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -5,11,figure_title,"Fig. 1 | Differentiation of bone-resident cell types. The mesenchymal lineage gives rise to skeletal stem and progenitor cells (SSPC) that can differentiate into cartilage-forming chondrocytes, bone-f","[606, 1353, 1122, 1494]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 1 | Differentiation of bone-resident cell types. The me""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +5,11,figure_title,"Fig. 1 | Differentiation of bone-resident cell types. The mesenchymal lineage gives rise to skeletal stem and progenitor cells (SSPC) that can differentiate into cartilage-forming chondrocytes, bone-f","[606, 1353, 1122, 1494]",figure_caption,0.92,"[""figure_title label: Fig. 1 | Differentiation of bone-resident cell types. The me""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 5,12,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 5,13,number,403,"[1088, 1524, 1124, 1542]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 6,0,paragraph_title,Review article,"[77, 80, 308, 117]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False 6,1,image,,"[78, 223, 1121, 1037]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -6,2,text,"Fig. 2 | Metabolic features of skeletal cells. Environmental cues lead to intracellular signalling, which in turn causes metabolic reprogramming. The metabolic pathways important for this Review inclu","[74, 1051, 583, 1214]",figure_caption_candidate,0.9,"[""figure prefix matched: Fig. 2 | Metabolic features of skeletal cells. Environmental"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,False,False +6,2,text,"Fig. 2 | Metabolic features of skeletal cells. Environmental cues lead to intracellular signalling, which in turn causes metabolic reprogramming. The metabolic pathways important for this Review inclu","[74, 1051, 583, 1214]",figure_caption,0.9,"[""figure prefix matched: Fig. 2 | Metabolic features of skeletal cells. Environmental"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True 6,3,vision_footnote,"histone and DNA modification to control skeletal cell fate and differentiation. Ac-CoA, acetyl coenzyme A; AMPK, AMP-activated protein kinase; CI–CIV, different complexes (C) of the ETC; CoQ, coenzyme","[607, 1050, 1119, 1194]",footnote,0.7,"[""vision_footnote label: histone and DNA modification to control skeletal cell fate a""]",footnote,0.7,body_zone,body_like,none,True,True 6,4,text,"maintain redox and energy balance and sustain proliferation $ ^{25} $. These metabolic changes also increase 2-hydroxyglutarate and succinate levels, which reduce ten-eleven translocation (TET) DNA de","[73, 1277, 593, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -6,5,text,,"[606, 1277, 1126, 1364]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +6,5,text,"cells use glycogenolysis to sustain their bioenergetic balance for longer +and they have increased ROS scavenging capacity. Conversely, deletion +of HIF1α in periosteal SSPCs reduces their survival and ","[606, 1277, 1126, 1364]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,6,text,"In summary, SSPCs display a high degree of metabolic plasticity, which enables them to function in changing microenvironments.","[606, 1364, 1125, 1408]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,7,text,"Osteoblasts use different nutrients to fulfil specific functions. Upon exposure to systemic or local osteogenic stimuli, SSPCs can differentiate into the osteogenic lineage. Osteoblasts are highly ana","[606, 1427, 1127, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 6,8,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -70,19 +78,27 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 7,0,paragraph_title,Review article,"[77, 80, 307, 115]",noise,0.8,"[""running header: review article""]",noise,0.8,body_zone,heading_like,short_fragment,False,False 7,1,text,"cells that produce large amounts of matrix, but unlike other secretory skeletal cell types such as chondrocytes, they often localize close to blood vessels $ ^{40} $.","[74, 223, 593, 288]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,2,text,"Metabolically, osteoblast differentiation relies on GLUT1-mediated glucose uptake and Glut1 inactivation in cells expressing Sp7 (also known as osterix) reduces bone mass (Fig. 3). In osteoblasts, glu","[73, 289, 594, 420]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -7,3,text,,"[605, 223, 1128, 419]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +7,3,text,"(encoded by Glut4, also known as Slc2a4), on the other hand, mediates +insulin-stimulated glucose uptake, and its expression increases dur- +ing osteoblast differentiation. Glut4 deletion in mature oste","[605, 223, 1128, 419]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,4,image,,"[82, 454, 1123, 1377]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -7,5,text,"Fig. 3 | Metabolic profile of skeletal stem and progenitor cells, and their osteogenic and adipogenic descendants. Scheme of the metabolic profile, its regulation and importance for the function of sk","[74, 1392, 570, 1494]",figure_caption_candidate,0.9,"[""figure prefix matched: Fig. 3 | Metabolic profile of skeletal stem and progenitor c"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,False,False -7,6,text,,"[613, 1392, 1132, 1475]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +7,5,text,"Fig. 3 | Metabolic profile of skeletal stem and progenitor cells, and their osteogenic and adipogenic descendants. Scheme of the metabolic profile, its regulation and importance for the function of sk","[74, 1392, 570, 1494]",figure_caption,0.9,"[""figure prefix matched: Fig. 3 | Metabolic profile of skeletal stem and progenitor c"", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True +7,6,text,"AMP-activated protein kinase; GLUT, glucose transporter; GSH, glutathione; HIF, +hypoxia-inducible transcription factor; MAS, malate-aspartate shuttle; NEAA, +non-essential amino acid; OXPHOS, oxidative","[613, 1392, 1132, 1475]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 7,7,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 7,8,number,405,"[1088, 1524, 1124, 1542]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,0,header,Review article,"[77, 80, 308, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 8,1,text,"or by being converted to malate by malic enzyme 2, especially during osteoblast differentiation $ ^{43} $. Malate is then considered to contribute to the malate–aspartate shuttle (MAS) that in osteobl","[73, 222, 594, 375]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,2,text,"Whether OXPHOS increases or decreases during osteoblast differentiation is still a matter of debate $ ^{43,45} $, and the contradictory observations might be explained by transient stage-specific fluc","[73, 374, 594, 849]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,3,text,"The availability of amino acids such as glutamine and proline is important for osteoblast functioning, primarily by supporting biosynthesis and redox homeostasis (Fig. 3). Proliferating osteoprogenito","[73, 848, 594, 1386]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,4,text,,"[605, 222, 1125, 311]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,4,text,"Slc13a5 in mature osteoblasts reduces cortical thickness and affects +matrix mineralization, without a clear effect on trabecular bone. Mech- +anistically, more glucose-derived citrate was detected in t","[605, 222, 1125, 311]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,5,text,"Metabolites not only regulate intracellular properties but can also function extracellularly. Citrate is such a metabolite as it is part of the TCA cycle and contributes to lipogenesis, but is also hi","[73, 1385, 594, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -8,6,text,,"[605, 310, 1127, 721]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +8,6,text,"mineral, but it remains unknown how citrate affects mineral integrity59. +Several in vivo studies indicate that metabolic pathways are +enhanced by bone anabolic agents and by stimulation of HIF signal-","[605, 310, 1127, 721]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,7,text,"Bone marrow adipocytes are a unique cell type. During ageing and in response to environmental or nutritional stimuli, marrow SSPCs or osteoadipogenic progenitors differentiate into BMAds, which progre","[606, 739, 1127, 1128]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,8,text,"Metabolically, the gene expression profile of adipogenic progenitors differs from that of osteogenic progenitors and is characterized by increased OXPHOS, but these in vitro data still need in vivo co","[605, 1127, 1128, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 8,9,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1522, 557, 1544]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False @@ -91,11 +107,13 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 9,1,text,"of Adipo-CAR cells and BMAds, and their metabolic interaction with surrounding skeletal and haematopoietic cells, is likely to contribute to our understanding of the bone phenotype in obesity, diabete","[73, 223, 594, 291]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,2,paragraph_title,Growth plate chondrocytes are adapted to a specific metabolic microenvironment,"[73, 306, 526, 352]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: Growth plate chondrocytes are adapted to a specific metaboli""]",section_heading,0.6,body_zone,heading_like,none,True,True 9,3,text,"During long-bone development, SSPCs not only differentiate into osteoblasts and BMAds, but also give rise to chondrocytes in the early phases of the developmental process $ ^{16} $. Chondrocytes are u","[73, 353, 595, 744]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -9,4,text,,"[605, 223, 1127, 589]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +9,4,text,"an energy deficit owing to reduced glucose oxidation, indicating that a +certain degree of mitochondrial respiration is still necessary in, prob- +ably, the peripherally located chondrocytes89. In line ","[605, 223, 1127, 589]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,5,text,"Glucose, taken up mainly by GLUT1, a process regulated by BMP-HIF1α $ ^{27} $, appears to be an essential nutrient for chondrocytes (Fig. 4b), as conditional Glut1 deletion decreases their proliferati","[605, 589, 1127, 743]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 9,6,image,,"[82, 782, 442, 1213]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True 9,7,image,,"[462, 778, 1119, 1401]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True -9,8,figure_title,"Fig. 4 | Metabolic regulation of chondrocyte function. a, Low lipid availability and low oxygen levels increase SOX9 expression, which stimulates the differentiation of skeletal stem and progenitor ce","[74, 1412, 582, 1494]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 4 | Metabolic regulation of chondrocyte function. a, Lo""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False +9,8,figure_title,"Fig. 4 | Metabolic regulation of chondrocyte function. a, Low lipid availability and low oxygen levels increase SOX9 expression, which stimulates the differentiation of skeletal stem and progenitor ce","[74, 1412, 582, 1494]",figure_caption,0.92,"[""figure_title label: Fig. 4 | Metabolic regulation of chondrocyte function. a, Lo""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True 9,9,vision_footnote,"chondrocyte function. Acan, aggrecan; Ac-CoA, acetyl coenzyme A; GLS1, glutaminase 1; GSH, glutathione; HIF, hypoxia-inducible transcription factor; PHGDH, phosphoglycerate dehydrogenase; ROS, reactiv","[606, 1412, 1114, 1493]",footnote,0.7,"[""vision_footnote label: chondrocyte function. Acan, aggrecan; Ac-CoA, acetyl coenzym""]",footnote,0.7,body_zone,body_like,none,True,True 9,10,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 557, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 9,11,number,407,"[1088, 1524, 1125, 1543]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False @@ -103,46 +121,55 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 10,1,text,"are equally important for chondrocyte function (for example, by supporting biosynthetic processes). Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in the serine synthesis pathway (SS","[73, 223, 594, 719]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,2,text,"The observation that TCA cycle anaplerosis by glucose is rather limited in chondrocytes suggests that these cells rely on other nutritional sources. Fatty acids are not a likely candidate, as these re","[73, 719, 594, 1149]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,3,text,"Although exogenous fatty acids seem to have minimal importance for chondrocyte function, glutamine has been shown to complement glucose in supporting chondrocyte anabolism as part of a feedforward pro","[73, 1150, 593, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True -10,4,text,,"[605, 223, 1126, 355]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,body_like,empty,False,True +10,4,text,"healing34. Yet, excessive glutamine flux must be avoided, as increased +glutamine-dependent α-ketoglutarate production, caused by consti- +tutively active HIF1α signalling, stimulates collagen hydroxyla","[605, 223, 1126, 355]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,5,paragraph_title,Metabolic adaptations during osteoclast differentiation,"[606, 371, 1026, 416]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic adaptations during osteoclast differentiation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True 10,6,text,Bone homeostasis and quality depend on a well-adjusted balance between osteoblasts and osteoclasts. Osteoclast differentiation critically depends on the production of RANKL (encoded by Tnfsf11) by ost,"[605, 418, 1128, 1406]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,7,text,"Besides fatty acids, glucose is another major nutrient for osteoclasts. GLUT1-mediated glucose uptake increases during osteoclast differentiation and is associated not only with enhanced OXPHOS but al","[604, 1407, 1128, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 10,8,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 557, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False 10,9,number,408,"[1088, 1524, 1125, 1542]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False -11,0,header,Review article,"[77, 80, 308, 115]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -11,1,image,,"[82, 228, 1111, 848]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,tail_nonref_hold_zone,unknown_like,empty,True,True -11,2,figure_title,"Fig. 5 | Metabolic regulation of osteoclast differentiation and activity. a, M-CSF and RANKL induce the differentiation of osteoclast progenitors to mature active osteoclasts by regulating the metabol","[74, 868, 541, 970]",figure_caption_candidate,0.92,"[""figure_title label: Fig. 5 | Metabolic regulation of osteoclast differentiation ""]",figure_caption,0.92,tail_nonref_hold_zone,legend_like,figure_number,False,False -11,3,vision_footnote,"palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fatty acid oxidation; GLUT1, glucose transporter 1; M-CSF, macrophage colony-stimulating factor; Me, methyl; OXPHOS, oxidative phosphorylation","[607, 867, 1123, 971]",footnote,0.7,"[""vision_footnote label: palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fa""]",footnote,0.7,tail_nonref_hold_zone,unknown_like,none,True,True -11,4,text,"for ATP synthesis $ ^{110,111} $. Glut1 deletion impairs glycolysis more than it impairs OXPHOS, and it also decreases in vitro osteoclastogenesis (Fig. 5b). Interestingly, Glut1 deletion in Lyz2-expr","[73, 1040, 593, 1342]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -11,5,text,"Amino acid metabolism also contributes to osteoclastogenesis, although, for some amino acids, the exact metabolic mechanism is not fully understood. Preosteoclasts take up glutamine via SLC1A5, which ","[74, 1342, 594, 1495]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True -11,6,text,,"[605, 1040, 1128, 1494]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True -11,7,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -11,8,number,409,"[1088, 1524, 1124, 1542]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -12,0,header,Review article,"[77, 81, 307, 117]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False -12,1,text,line with the observation that Tie2-Cre-mediated deletion of Arg1 does not affect osteoclast properties at baseline $ ^{117} $. Whether Arg1-conditional knockout mice are more susceptible to inflammat,"[74, 222, 593, 356]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,2,paragraph_title,Metabolic disturbance during bone pathology,"[74, 371, 548, 397]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic disturbance during bone pathology""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,True,True -12,3,text,"Most studies investigating skeletal cell metabolism have been performed during bone development, but more recent evidence suggests that alterations in specific metabolic pathways underly skeletal path","[73, 397, 593, 484]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,4,paragraph_title,Metabolic dysfunction in osteoarthritic chondrocytes is associated with disease progression,"[73, 502, 542, 547]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: Metabolic dysfunction in osteoarthritic chondrocytes is asso""]",section_heading,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -12,5,text,"Osteoarthritis is a complex, multifactorial disease that is characterized by the progressive deterioration of the articular cartilage and structural changes to the entire joint, leading to severe disa","[73, 546, 594, 851]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,body_like,none,True,True -12,6,paragraph_title,Box 1 Osteoarthritis: a largely unmet clinical problem,"[87, 891, 554, 1021]",structured_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Box 1 Osteoarthritis: a largely unmet clinical problem""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,False,False -12,7,footer,,"[87, 939, 554, 1021]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,empty,False,False -12,8,text,"Osteoarthritis is the most common degenerative joint disease, and occurs with increasing prevalence due to our ageing population. It represents a major public health burden, as current therapies are l","[84, 1039, 572, 1475]",noise,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,False,False -12,9,text,,"[605, 223, 1127, 612]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,tail_nonref_hold_zone,unknown_like,empty,False,True -12,10,text,"Osteoarthritic chondrocytes also display changes in lipid metabolism, as evidenced by increased cholesterol uptake, increased expression of cholesterol hydroxylases (CH25H and CYP7B1) and enhanced pro","[605, 612, 1127, 805]",noise,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,False,False -12,11,text,"Finally, amino acid-metabolizing pathways also appear to be altered in osteoarthritic chondrocytes $ ^{32} $, although in vivo data are still limited. ARG2, which converts the conditionally essential ","[605, 805, 1128, 1107]",noise,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,False,False -12,12,paragraph_title,Metabolic alterations in osteolineage cells during diabetic bone loss,"[607, 1124, 1116, 1169]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic alterations in osteolineage cells during diabetic ""]",subsection_heading,0.6,tail_nonref_hold_zone,heading_like,none,False,True -12,13,text,"There is increasing evidence that diabetes is associated with increased bone fracture risk, although the underlying cellular and molecular mechanisms are not well understood and are probably multiface","[606, 1170, 1128, 1495]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -12,14,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False -12,15,number,410,"[1091, 1524, 1126, 1543]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +11,0,header,Review article,"[77, 80, 308, 115]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,1,image,,"[82, 228, 1111, 848]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True +11,2,figure_title,"Fig. 5 | Metabolic regulation of osteoclast differentiation and activity. a, M-CSF and RANKL induce the differentiation of osteoclast progenitors to mature active osteoclasts by regulating the metabol","[74, 868, 541, 970]",figure_caption,0.92,"[""figure_title label: Fig. 5 | Metabolic regulation of osteoclast differentiation ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +11,3,vision_footnote,"palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fatty acid oxidation; GLUT1, glucose transporter 1; M-CSF, macrophage colony-stimulating factor; Me, methyl; OXPHOS, oxidative phosphorylation","[607, 867, 1123, 971]",footnote,0.7,"[""vision_footnote label: palmitoyltransferase 2; DNMT, DNA methyltransferase; FAO, fa""]",footnote,0.7,body_zone,body_like,none,True,True +11,4,text,"for ATP synthesis $ ^{110,111} $. Glut1 deletion impairs glycolysis more than it impairs OXPHOS, and it also decreases in vitro osteoclastogenesis (Fig. 5b). Interestingly, Glut1 deletion in Lyz2-expr","[73, 1040, 593, 1342]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"Amino acid metabolism also contributes to osteoclastogenesis, although, for some amino acids, the exact metabolic mechanism is not fully understood. Preosteoclasts take up glutamine via SLC1A5, which ","[74, 1342, 594, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,6,text,"outcome differs depending on whether the transporter or metabolic +enzyme is inactivated114–116. The SLC7A5 transporter mediates uptake +of large neutral amino acids, including the essential amino acids","[605, 1040, 1128, 1494]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,7,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +11,8,number,409,"[1088, 1524, 1124, 1542]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,header,Review article,"[77, 81, 307, 117]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,1,text,line with the observation that Tie2-Cre-mediated deletion of Arg1 does not affect osteoclast properties at baseline $ ^{117} $. Whether Arg1-conditional knockout mice are more susceptible to inflammat,"[74, 222, 593, 356]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,2,paragraph_title,Metabolic disturbance during bone pathology,"[74, 371, 548, 397]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic disturbance during bone pathology""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +12,3,text,"Most studies investigating skeletal cell metabolism have been performed during bone development, but more recent evidence suggests that alterations in specific metabolic pathways underly skeletal path","[73, 397, 593, 484]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,4,paragraph_title,Metabolic dysfunction in osteoarthritic chondrocytes is associated with disease progression,"[73, 502, 542, 547]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: Metabolic dysfunction in osteoarthritic chondrocytes is asso""]",section_heading,0.6,body_zone,body_like,none,True,True +12,5,text,"Osteoarthritis is a complex, multifactorial disease that is characterized by the progressive deterioration of the articular cartilage and structural changes to the entire joint, leading to severe disa","[73, 546, 594, 851]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,6,paragraph_title,Box 1 Osteoarthritis: a largely unmet clinical problem,"[87, 891, 554, 1021]",structured_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Box 1 Osteoarthritis: a largely unmet clinical problem""]",subsection_heading,0.6,body_zone,heading_like,none,False,False +12,7,footer,,"[87, 939, 554, 1021]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +12,8,text,"Osteoarthritis is the most common degenerative joint disease, and occurs with increasing prevalence due to our ageing population. It represents a major public health burden, as current therapies are l","[84, 1039, 572, 1475]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,9,text,"In addition to the mitochondrial defects, glycolysis is enhanced in +osteoarthritic chondrocytes, probably reflecting their hypoxic micro- +environment, but perhaps also as a metabolic compensation for ","[605, 223, 1127, 612]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,10,text,"Osteoarthritic chondrocytes also display changes in lipid metabolism, as evidenced by increased cholesterol uptake, increased expression of cholesterol hydroxylases (CH25H and CYP7B1) and enhanced pro","[605, 612, 1127, 805]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,11,text,"Finally, amino acid-metabolizing pathways also appear to be altered in osteoarthritic chondrocytes $ ^{32} $, although in vivo data are still limited. ARG2, which converts the conditionally essential ","[605, 805, 1128, 1107]",noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +12,12,paragraph_title,Metabolic alterations in osteolineage cells during diabetic bone loss,"[607, 1124, 1116, 1169]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Metabolic alterations in osteolineage cells during diabetic ""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +12,13,text,"There is increasing evidence that diabetes is associated with increased bone fracture risk, although the underlying cellular and molecular mechanisms are not well understood and are probably multiface","[606, 1170, 1128, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,14,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[75, 1523, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False +12,15,number,410,"[1091, 1524, 1126, 1543]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False 13,0,header,Review article,"[77, 80, 308, 115]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False -13,1,text,"that bone marrow SSPCs from these diabetic mice display a reduction in glycolysis, which is associated with decreased expression of osteogenic genes $ ^{129} $. Glut1 deletion in Sp7-expressing osteol","[73, 223, 594, 570]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,1,text,"that bone marrow SSPCs from these diabetic mice display a reduction in glycolysis, which is associated with decreased expression of osteogenic genes $ ^{129} $. Glut1 deletion in Sp7-expressing osteol","[73, 223, 594, 570]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,2,paragraph_title,Are malignant cells in the bone environment metabolically adapted?,"[73, 587, 529, 631]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Are malignant cells in the bone environment metabolically ad""]",subsection_heading,0.6,body_zone,heading_like,none,True,True -13,3,text,"Metastatic cancer cells are considered to have a specific metabolic profile that is adapted to the local microenvironment of the tissue they home to $ ^{[131,132]} $, but whether tumour cells that for","[73, 634, 594, 1063]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -13,4,text,"The bone microenvironment also contributes to the progression of haematological malignancies by influencing their metabolic profile, often by unidirectional or bidirectional metabolite exchange $ ^{13","[73, 1064, 594, 1495]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -13,5,text,,"[604, 223, 1127, 399]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,,unknown_like,empty,False,True +13,3,text,"Metastatic cancer cells are considered to have a specific metabolic profile that is adapted to the local microenvironment of the tissue they home to $ ^{[131,132]} $, but whether tumour cells that for","[73, 634, 594, 1063]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,4,text,"The bone microenvironment also contributes to the progression of haematological malignancies by influencing their metabolic profile, often by unidirectional or bidirectional metabolite exchange $ ^{13","[73, 1064, 594, 1495]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +13,5,text,"Chronic lymphocytic leukaemia (CLL) cells also metabolically +interact with bone cells to produce GSH. In general, GSH synthesis +depends on the uptake of cystine, which is then converted to cysteine, +t","[604, 223, 1127, 399]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,6,paragraph_title,Conclusions,"[608, 415, 744, 438]",section_heading,0.9,"[""explicit scholarly heading: Conclusions""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True -13,7,text,"Over the past decade, substantial progress has been made in unravelling skeletal cell metabolism and its contribution to cell-specific behaviour. These findings highlight that nutrient availability ch","[605, 438, 1127, 697]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True -13,8,text,"However, several questions remain to be answered. For example, are metabolic interactions between different skeletal cell types important? Is the metabolism of skeletal cells altered during bone patho","[605, 697, 1128, 1088]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,7,text,"Over the past decade, substantial progress has been made in unravelling skeletal cell metabolism and its contribution to cell-specific behaviour. These findings highlight that nutrient availability ch","[605, 438, 1127, 697]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,8,text,"However, several questions remain to be answered. For example, are metabolic interactions between different skeletal cell types important? Is the metabolism of skeletal cells altered during bone patho","[605, 697, 1128, 1088]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True 13,9,paragraph_title,Published online: 18 March 2024 References,"[608, 1106, 856, 1168]",frontmatter_noise,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Published online: 18 March 2024 References""]",subsection_heading,0.6,body_zone,support_like,none,False,False 13,10,footer,,"[609, 1150, 702, 1168]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,empty,False,False 13,11,reference_content,"1. Peck, W. A., Birge, S. J. Jr. & Fedak, S. A. Bone cells: biochemical and biological studies after enzymatic isolation. Science 146, 1476–1477 (1964).","[609, 1169, 1108, 1201]",reference_item,0.85,"[""reference content label: 1. Peck, W. A., Birge, S. J. Jr. & Fedak, S. A. Bone cells: ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True @@ -295,16 +322,16 @@ page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_ 15,60,reference_content,"142. van Gastel, N. et al. Induction of a timed metabolic collapse to overcome cancer chemoresistance. Cell Metab. 32, 391–403.e6 (2020).","[611, 993, 1078, 1022]",reference_item,0.85,"[""reference content label: 142. van Gastel, N. et al. Induction of a timed metabolic co""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 15,61,reference_content,"143. Zhang, W. et al. Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat. Cell Biol. 14, 276–286 (2012).","[611, 1025, 1114, 1055]",reference_item,0.85,"[""reference content label: 143. Zhang, W. et al. Stromal control of cystine metabolism ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True 15,62,reference_content,"144. Panaroni, C. et al. Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins. Blood 139, 876–888 (2022).","[610, 1057, 1118, 1087]",reference_item,0.85,"[""reference content label: 144. Panaroni, C. et al. Multiple myeloma cells induce lipol""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True -15,63,paragraph_title,Acknowledgements,"[610, 1102, 767, 1119]",backmatter_heading,0.8,"[""backmatter heading on page 15: Acknowledgements""]",backmatter_heading_candidate,0.8,,unknown_like,short_fragment,True,True +15,63,paragraph_title,Acknowledgements,"[610, 1102, 767, 1119]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,True,True 15,64,text,"The authors thank Fonds voor Wetenschappelijk Onderzoek-Flanders for funding: EOS-GOF8218N, GOB3418N, GOC5120, G071321N, Hercules-I013518N.","[609, 1120, 1054, 1152]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -15,65,paragraph_title,Author contributions,"[609, 1166, 773, 1183]",backmatter_heading,0.8,"[""backmatter heading on page 15: Author contributions""]",backmatter_heading_candidate,0.8,,support_like,none,True,True -15,66,text,The authors contributed equally to all aspects of the article.,"[609, 1184, 937, 1200]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -15,67,paragraph_title,Competing interests,"[610, 1214, 770, 1231]",backmatter_heading,0.8,"[""backmatter heading on page 15: Competing interests""]",backmatter_heading_candidate,0.8,,unknown_like,short_fragment,True,True -15,68,text,The authors declare no competing interests.,"[613, 1235, 854, 1248]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,65,paragraph_title,Author contributions,"[609, 1166, 773, 1183]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True +15,66,text,The authors contributed equally to all aspects of the article.,"[609, 1184, 937, 1200]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,67,paragraph_title,Competing interests,"[610, 1214, 770, 1231]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing interests""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,short_fragment,False,True +15,68,text,The authors declare no competing interests.,"[613, 1235, 854, 1248]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 15,69,paragraph_title,Additional information,"[609, 1261, 785, 1279]",backmatter_heading,0.5,"[""backmatter boundary candidate: Additional information""]",backmatter_boundary_candidate,0.5,,unknown_like,none,True,True -15,70,text,"Peer review information Nature Reviews Endocrinology thanks Martina Rauner, Ryan Riddle and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.","[608, 1280, 1109, 1313]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,70,text,"Peer review information Nature Reviews Endocrinology thanks Martina Rauner, Ryan Riddle and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.","[608, 1280, 1109, 1313]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 15,71,text,Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.,"[608, 1328, 1084, 1361]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,support_like,none,True,True -15,72,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[607, 1376, 1104, 1441]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True -15,73,text,© Springer Nature Limited 2024,"[608, 1455, 789, 1473]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,72,text,Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving,"[607, 1376, 1104, 1441]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +15,73,text,© Springer Nature Limited 2024,"[608, 1455, 789, 1473]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True 15,74,footer,Nature Reviews Endocrinology | Volume 20 | July 2024 | 399–413,"[76, 1524, 556, 1543]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False 15,75,number,413,"[1092, 1524, 1124, 1542]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False diff --git a/tests/fixtures/ocr_real_papers/VFS8CBW2/block_trace.csv b/tests/fixtures/ocr_real_papers/VFS8CBW2/block_trace.csv new file mode 100644 index 00000000..bcf9ea18 --- /dev/null +++ b/tests/fixtures/ocr_real_papers/VFS8CBW2/block_trace.csv @@ -0,0 +1,411 @@ +page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default +2,0,header,Journal Pre-proof,"[475, 52, 713, 82]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p2 y=52/1684"", ""page_1_preproof_cover_dropped_upstream""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +2,1,doc_title,Directionalities of magnetic fields and topographic scaffolds synergise to enhance MSC chondrogenesis,"[95, 100, 1046, 171]",paper_title,0.8,"[""page-1 zone title_zone: Directionalities of magnetic fields and topographic scaffold""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True +2,2,text,"Cenk Celik $ ^{1} $, Alfredo Franco-Obregón $ ^{2,3,4,5*} $, Eng Hin Lee $ ^{1,6} $, James HP Hui $ ^{1,6} $, Zheng Yang $ ^{1,6*} $","[119, 234, 1022, 298]",authors,0.8,"[""page-1 zone author_zone: Cenk Celik $ ^{1} $, Alfredo Franco-Obreg\u00f3n $ ^{2,3,4,5*} $,""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True +2,3,text,"Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228","[83, 422, 986, 485]",affiliation,0.8,"[""page-1 zone affiliation_zone: Department of Orthopaedic Surgery, Yong Loo Lin School of Me""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +2,4,text,"2 Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228","[83, 491, 978, 554]",affiliation,0.8,"[""page-1 zone affiliation_zone: 2 Department of Surgery, Yong Loo Lin School of Medicine, Na""]",affiliation,0.8,frontmatter_main_zone,reference_like,reference_numeric_dot,True,True +2,5,text,"Biolonic Currents Electromagnetic Pulsing Systems Laboratory, BICEPS, National University of Singapore, Singapore, 117599","[83, 559, 1005, 624]",affiliation,0.8,"[""page-1 zone affiliation_zone: Biolonic Currents Electromagnetic Pulsing Systems Laboratory""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +2,6,text,"4 Institute for Health Innovation & Technology, iHealthtech, National University of Singapore, Singapore, 117599","[83, 629, 966, 692]",affiliation,0.8,"[""page-1 zone affiliation_zone: 4 Institute for Health Innovation & Technology, iHealthtech,""]",affiliation,0.8,frontmatter_main_zone,reference_like,reference_numeric_dot,True,True +2,7,text,"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, DSO (Kent Ridge) Building, #04-01, 27 Medical Drive, Singapore, 117593","[83, 697, 1047, 762]",affiliation,0.8,"[""page-1 zone affiliation_zone: Department of Physiology, Yong Loo Lin School of Medicine, N""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +2,8,text,"Tissue Engineering Program (NUSTEP), Life Sciences Institute, National University of Singapore, DSO (Kent Ridge) Building, #04-01, 27 Medical Drive, Singapore, 117510","[82, 767, 1026, 832]",affiliation,0.8,"[""page-1 zone affiliation_zone: Tissue Engineering Program (NUSTEP), Life Sciences Institute""]",affiliation,0.8,frontmatter_main_zone,support_like,none,True,True +2,9,text,"* Corresponding authors: Zheng Yang, dosyz@nus.edu.sg; Alfredo Franco-Obregón, suraf@nus.edu.sg","[84, 925, 1019, 956]",frontmatter_support,0.78,"[""first-surviving-page support text: * Corresponding authors: Zheng Yang, dosyz@nus.edu.sg; Alfre""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True +2,10,number,1,"[1039, 1561, 1054, 1584]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False +3,0,header,Journal Pre-proof,"[475, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p3 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +3,1,paragraph_title,Abstract,"[85, 102, 190, 128]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,body_zone,heading_like,short_fragment,True,True +3,2,text,"Mesenchymal stem cell (MSC) chondrogenesis is modulated by diverse biophysical cues. +We have previously shown that brief, low-amplitude pulsed electromagnetic fields +(PEMFs) differentially enhance MSC","[84, 163, 1052, 455]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,3,text,"chondrogenesis. MSCs on TCP or the ALN scaffolds exhibited greater resting mechanical stress and accordingly, were unresponsive, or negatively responsive, to PEMF exposure","[85, 877, 1048, 962]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,4,text,from all directions. The efficacy of PEMF-induced MSC chondrogenesis is hence regulated,"[84, 985, 1056, 1014]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,5,text,"responses, culminating in a final cellular response. The combined contributions of +micromechanical environment and magnetic field orientation hence will need to be +considered when designing magnetic e","[85, 1095, 964, 1237]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,6,text,"Keywords: pulsed electromagnetic fields, mesenchymal stem cells, electrospun fibres, chondrogenesis, mechanotransduction","[84, 1316, 1016, 1401]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False +3,7,number,2,"[1038, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p4 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +4,1,paragraph_title,1. Introduction,"[85, 103, 268, 128]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +4,2,text,"Mesenchymal stem cells (MSCs) exhibit multipotency to differentiate into multiple cell lineages including osteoblasts, adipocytes, chondrocytes and myocytes [1,2]. Preclinical studies have demonstrate","[84, 160, 1057, 629]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,3,paragraph_title,Studies have examined the interaction between stem cells and different,"[83, 668, 852, 694]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: Studies have examined the interaction between stem cells and""]",section_heading,0.6,body_zone,body_like,none,True,True +4,4,text,"microenvironmental cues presented on functionalised scaffolds [8], as well as the efficacies of different stimulation protocols [9,10] in inducing MSC-based cartilage regeneration. Substrate-mediated ","[84, 695, 1055, 1192]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,5,text,[14]. Mechanotransduction within the cell is dependent on FA and cytoskeleton actin dynamics regulated by tyrosine (FAK) [15–17] and serine-threonine kinases (MAPK) [18] as well as transcriptional lev,"[85, 1218, 1035, 1414]",body_paragraph,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,body_zone,reference_like,reference_numeric_bracket,True,True +4,6,text,"We have previously demonstrated that brief exposure to PEMFs (10 minutes), applied +once during early chondrogenic induction, were most efficacious at promoting MSC","[85, 1451, 1004, 1537]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,7,number,3,"[1038, 1562, 1055, 1583]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +5,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p5 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +5,1,text,"chondrogenesis in pellet cultures [23], whereby the exposure parameters were established by targeting the developmental expression of certain Transient Receptor Potential channels previously implicate","[83, 94, 1051, 1075]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,2,paragraph_title,2. Materials and Methods 2.1. Fabrication and characterisation of electrospun fibrous scaffolds,"[84, 1188, 854, 1270]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods 2.1. Fabrication and characterisati""]",section_heading,0.85,body_zone,body_like,heading_numbered,True,True +5,3,footer,,"[120, 1243, 854, 1270]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +5,4,text,"Poly(lacto-co-caprolactone) (PLCL, PURASORB PLC 7015, Corbion, the Netherlands) was dissolved in 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP, Sigma-Aldrich, Germany) to form a 10% PLCL/HFIP solution. Elec","[84, 1298, 1052, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +5,5,number,4,"[1039, 1562, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +6,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p6 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +6,1,text,"voltage supply of 15 kV. Randomly-oriented (RND) and parallel aligned fibres (ALN) were fabricated with the rotating collector set at 300 and 3000 rpm, respectively. Scanning electron micrographs were","[84, 103, 1048, 576]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,2,paragraph_title,2.2. Human bone marrow-derived MSC culture,"[120, 611, 623, 638]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Human bone marrow-derived MSC culture""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,3,text,"Human bone marrow mesenchymal stem cells (MSCs) were purchased from RoosterBio, Inc. (Maryland, USA) at passage 3. MSCs were further expanded in RoosterBasal™ Protein Free medium supplemented with Roo","[83, 668, 1036, 862]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,4,paragraph_title,2.3. MSC chondrogenic differentiation,"[122, 900, 528, 926]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. MSC chondrogenic differentiation""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +6,5,text,"Chondrogenic differentiation of MSCs was induced three days after seeding the MSCs onto three different topographies, namely, polystyrene tissue culture plastic (TCP; Cellstar® 24-well multiwell plate","[85, 954, 1049, 1544]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +6,6,number,5,"[1038, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +7,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p7 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +7,1,text,"proline, 50 $ \mu $g/ml ascorbic acid, 1% ITS-Premix (Becton-Dickinson, San Jose, USA), 1 mM sodium pyruvate, $ 10^{-7} $ M dexamethasone (Sigma-Aldrich, St Louis, USA) and 10 ng/ml transforming gro","[84, 102, 1053, 464]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,2,paragraph_title,2.4. PEMF exposure paradigm,"[121, 489, 451, 518]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. PEMF exposure paradigm""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,3,text,"The PEMF delivery device used in this study has been previously described [23,31,32].","[85, 544, 1014, 572]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,4,text,"The PEMF delivery device used in this study has been previously described. +MSCs on TCP, RND and ALN scaffolds were first subjected to single exposures ranging from 0 - 3 mT for 10 min administered in ","[84, 548, 1049, 961]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,5,text,"topographies were subjected to PEMFs, applied in different directions, as shown in Figure 1. Briefly, MSCs in chondrogenic differentiation medium were exposed for 10 min to PEMFs at an amplitude of 1 ","[84, 987, 1044, 1347]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,6,paragraph_title,2.5. Cell apoptosis,"[121, 1384, 325, 1412]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Cell apoptosis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +7,7,text,"Caspase-3/7 activity was measured using the Caspase-Glo $ ^{\textregistered} $ 3/7 Assay kit (Promega, Madison, USA). Briefly, the add-mix-measure reagent was added to MSC-seeded","[84, 1440, 993, 1524]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +7,8,number,6,"[1039, 1562, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +8,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p8 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +8,1,text,"topographies at room temperature and then was shaken at 400 rpm for 30 s, followed by a 30-min of incubation at room temperature. The apoptosis assay was carried out at Day 1 and Day 3 of differentiat","[84, 103, 1053, 243]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,2,paragraph_title,2.6. Cell proliferation,"[121, 280, 348, 307]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Cell proliferation""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,3,text,"Cell viability was evaluated with alamarBlue $ ^{\circledR} $ Cell Proliferation assay (Bio-Rad) according to the manufacturer's protocol. Briefly, 10x alamarBlue $ ^{\circledR} $ was diluted to 1:10 ","[83, 334, 1050, 755]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,4,paragraph_title,2.7. Real-time PCR analyses,"[121, 789, 436, 817]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Real-time PCR analyses""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,5,text,"Total mRNA was extracted using the TRIzol $ ^{\circledR} $ Reagent (Thermo Fischer Scientific) and purified using RNeasy $ ^{\circledR} $ Mini Kit (Qiagen, Germany). Reverse transcription was conducte","[83, 845, 1053, 1317]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,6,paragraph_title,2.8. Immunofluorescence staining,"[121, 1354, 486, 1381]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Immunofluorescence staining""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +8,7,text,"Cells were fixed in 10% neutral-buffered formalin solution (Sigma-Aldrich), permeabilised with Triton X-100 (0.1%, Sigma-Aldrich), followed by blocking in Ultra V Block (Thermo Scientific). Samples we","[84, 1408, 1035, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +8,8,number,7,"[1038, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +9,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p9 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +9,1,text,"Chemicon Inc.), COL I (Clone C245B, Sigma-Aldrich) and Aggrecan (AlexaFluor $ ^{\text{®}} $ 647-conjugated anti-mouse aggrecan, Santa Cruz Biotechnology), or cytoskeletal proteins pFAK (ab81298, Abcam","[84, 101, 1047, 797]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,2,paragraph_title,2.9. Western blotting,"[121, 832, 348, 860]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Western blotting""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +9,3,text,Cells were harvested 1 h following PEMF exposure and lysed by M-PER $ ^{\text{®}} $ Mammalian Protein Extraction Reagent (Thermo Scientific) supplemented with Pierce $ ^{\text{™}} $ Protease and Phosp,"[81, 888, 1050, 1527]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +9,4,number,8,"[1039, 1562, 1055, 1583]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +10,0,header,Journal Pre-proof,"[476, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p10 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +10,1,text,"anti-YAP (63.7) antibody (sc-101199, Santa Cruz Biotechnology). Blots were incubated in horseradish peroxidase (HRP)-conjugated anti-mouse (ab97023, Abcam) or anti-rabbit secondary antibodies (ab6721,","[83, 102, 1043, 354]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,2,paragraph_title,2.10. Mitochondrial Stress Measurements,"[120, 390, 622, 417]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. Mitochondrial Stress Measurements""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +10,3,text,"Effects of PEMFs on mitochondrial stress was assessed by the Mitochondrial Stress Test Complete Assay Kit (ab232857, Abcam). Briefly, 6 ×10³ cells/well were seeded onto scaffolds, placed in a 96-well ","[83, 444, 1061, 1414]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,4,paragraph_title,2.11. Statistical Analysis,"[120, 1451, 438, 1478]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.11. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True +10,5,text,All experiments were performed in biological replicates (n = 3). Statistical analyses were,"[84, 1507, 1025, 1536]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +10,6,number,9,"[1039, 1562, 1055, 1582]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +11,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p11 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +11,1,text,assessed by Student's t-test for comparison of PEMF directions within a topography; whereas ordinary one-way ANOVA was used for multiple comparisons across different topographies in GraphPad Prism 8 s,"[84, 104, 1046, 355]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,2,paragraph_title,3. Results 3.1. Characterisation of electrospun scaffolds,"[84, 458, 608, 541]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results 3.1. Characterisation of electrospun scaffolds""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +11,3,footer,,"[123, 513, 608, 541]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +11,4,text,SEM images (Fig. 2A) showed the distinct nanofibrillar organisations present in the random (RND) and aligned (ALN) scaffolds (Fig. 2B). RND and ALN nanofibers had comparable fibre diameters (Fig. 2C; ,"[82, 564, 1050, 1263]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +11,5,text,"3.2. Optimisation of PEMF conditions for MSC chondrogenesis on fibrous scaffolds +MSCs seeded onto TCP, RND or ALN scaffolds were subjected to Z-directed PEMFs, ranging from 1 - 3 mT for 10 min on the ","[84, 1299, 1056, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +11,6,number,10,"[1028, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +12,0,header,Journal Pre-proof,"[476, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p12 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +12,1,text,"and ACAN in response to exposure at 2 mT PEMFs (Fig. 3A). By contrast, MSC chondrogenesis on the RND scaffolds was dramatically augmented by exposure to 1 mT PEMFs, associated with upregulations of SO","[84, 103, 1041, 574]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,2,text,"We investigated the consequences of repetitive PEMF exposures over MSC chondrogenesis on the RND scaffolds (Fig. 3B). PEMFs at 1 mT were administered once (day 1), twice (days 1 and 2) or thrice (day ","[83, 614, 1043, 1305]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,3,paragraph_title,3.3. Effect of directional PEMF on MSC chondrogenesis,"[120, 1342, 721, 1369]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Effect of directional PEMF on MSC chondrogenesis""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +12,4,text,"After defining a reference PEMF efficacy window, the chondrogenic consequences of directional PEMFs and surface topography were examined (Fig. 1). Z-directed PEMFs resulted in elevated transcript leve","[84, 1396, 1057, 1536]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +12,5,number,11,"[1028, 1561, 1054, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +13,0,header,Journal Pre-proof,"[476, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p13 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +13,1,text,"the RND scaffolds, but not when applied to MSCs on TCP or ALN scaffolds (Fig. 4A). By contrast, X-directed PEMFs either reduced or had no effect over the expressions of these same chondrogenic markers","[84, 102, 1050, 629]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,2,text,"Immunofluorescence staining for COL II, ACAN and COL I at 21-days following PEMF exposure demonstrated significantly enhanced depositions of COL II and ACAN in response to Z-directed PEMFs delivered t","[83, 669, 1051, 1196]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,3,paragraph_title,3.4. Effects of directional PEMFs on MSC proliferation and viability,"[121, 1231, 835, 1258]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Effects of directional PEMFs on MSC proliferation and v""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +13,4,text,"The effects of directional PEMF exposure over MSC apoptosis on TCP, RND and ALN scaffolds were analysed. Caspase-3/7 activity increased over three days for MSCs on TCP under all conditions and was fur","[83, 1286, 1056, 1537]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +13,5,number,12,"[1028, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +14,0,header,Journal Pre-proof,"[476, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p14 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +14,1,text,unaffected by PEMF exposure of any orientation. Apoptosis was initially lowest for MSCs on the ALN scaffolds and was further inhibited by PEMFs in the plane of the dish (Y- and X-directed PEMFs) at da,"[83, 103, 1056, 634]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,2,paragraph_title,3.5. Dynamic effects of directional PEMFs on cell morphology,"[121, 666, 782, 695]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Dynamic effects of directional PEMFs on cell morphology""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,3,text,"Changes in MSC morphology, indicative of mechanical force distribution, were monitored on TCP, RND and ALN scaffolds immediately before PEMF (bP), immediately post-PEMF (iPP), 1-hour post-PEMF (1hPP) ","[84, 720, 1057, 1191]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,4,paragraph_title,3.6. Effects of directional PEMF on focal adhesion kinase,"[121, 1231, 735, 1257]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.6. Effects of directional PEMF on focal adhesion kinase""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +14,5,text,"The response of MSCs to PEMF orientation and substrate was examined at the level of focal adhesion assembly (Fig. 5B, D-E, F-G) and cytoskeletal organisation (Fig. 5B). MSCs on TCP were characterised ","[83, 1287, 1026, 1537]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +14,6,number,13,"[1028, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +15,0,header,Journal Pre-proof,"[476, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p15 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +15,1,text,"polygonal morphology but were smaller in size and lacked prominent stress fibre networks, whereas MSCs on the ALN scaffolds were elongated, assuming the orientation of the scaffold fibre alignment, an","[83, 103, 1061, 868]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,2,text,"pFAK size and dimensions was also subject to modulation by field orientation. The pFAK staining observed in MSCs on TCP and the ALN scaffolds were most elongated, whereas those in MSCs on the RND scaf","[83, 898, 1052, 1315]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,3,text,"pFAK-mediated mechanotransduction via the ERK and P38 signalling pathways [35–37] was investigated (Fig. 5F-G). FAK phosphorylation was reduced by Z-directed PEMFs for MSCs on TCP, whereas they exerte","[84, 1352, 1045, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +15,4,number,14,"[1027, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +16,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p16 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +16,1,text,"both the RND and ALN scaffolds, whereas they had no effect on MSCs on TCP. ERK phosphorylation was reduced by X-directed PEMFs on the RND and ALN scaffolds. Notably, PEMFs of either Z or X orientation","[83, 103, 1046, 577]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,2,paragraph_title,3.7. Dynamic effects of directional PEMFs on YAP expression,"[121, 612, 784, 638]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.7. Dynamic effects of directional PEMFs on YAP expression""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +16,3,text,"YAP, a mechanosensitive transcriptional co-activator [38,39], exhibited predominantly cytoplasmic localisation in MSCs on the RND scaffolds, whereas greater nuclear localisation was detected in MSCs o","[83, 662, 1054, 1471]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +16,4,paragraph_title,3.8. Role of pFAK in transducing PEMF effect on MSC chondrogenesis,"[121, 1507, 881, 1535]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.8. Role of pFAK in transducing PEMF effect on MSC chondrog""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True +16,5,number,15,"[1027, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +17,0,header,Journal Pre-proof,"[476, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p17 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +17,1,text,"Inhibition of FAK phosphorylation confirmed the role of pFAK in transducing the effects of directional PEMFs on MSC chondrogenesis within the RND scaffolds. The pFAK inhibitor, PF573228 (pFAKi), suppr","[84, 103, 1053, 855]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +17,2,text,"3.9. Effects of directional PEMFs on mitochondrial stress and the role of pFAK +Prior reports have shown that analogous PEMFs exert developmental consequences by modulating mitochondrial function [24,3","[84, 887, 1055, 1527]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,heading_numbered,True,True +17,3,number,16,"[1027, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +18,0,header,Journal Pre-proof,"[477, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p18 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +18,1,text,but was strongly suppressed pFAK inhibition in all conditions.,"[84, 102, 741, 131]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,2,paragraph_title,4. Discussion,"[85, 237, 256, 264]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +18,3,text,"Existing studies examining the capacity of PEMF-based strategies to promote MSC chondrogenesis have generated conflicting results. Notable discrepancies are the duration and frequency of exposure, whe","[83, 292, 1046, 1151]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,4,text,The distinct substrates compared in this study established diverse micromechanical cellular environments. MSCs on TCP and the ALN scaffolds displayed morphologies and cytoskeletal arrangements charact,"[83, 1189, 1040, 1549]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +18,5,number,17,"[1028, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +19,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p19 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +19,1,text,cytoplasmic YAP localisation.,"[84, 103, 404, 131]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,2,text,"MSCs with rounded morphologies are associated with great chondrogenic potential [44,45], coinciding with evidence that low levels of cytoskeleton tension are more +permissive for chondrogenesis [46,47]","[84, 172, 1054, 808]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,3,text,"Both RND and ALN fibrous scaffolds have previously been demonstrated to be conducive for MSC chondrogenesis [53,54], with ALN fibres biasing differentiation towards a fibrocartilage phenotype [29,30],","[83, 847, 1049, 1538]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +19,4,number,18,"[1028, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +20,0,header,Journal Pre-proof,"[476, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p20 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +20,1,text,which Z-directed PEMFs to promote MSC-chondrogenesis chondrogenesis.,"[84, 102, 893, 131]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,2,text,"PEMFs administered parallel to the plane of the tissue culture dish, in either the X or Y directions, attenuated cell proliferation on either nanofibrous scaffold (Fig. 3E). Viability of MSCs was not ","[84, 172, 1050, 643]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,3,text,"Agreeing with our previous report examining PEMF-induced MSC chondrogenesis in pellet cultures [23], a single 10-min exposure administered at the start of differentiation induction was more chondrogen","[84, 679, 1049, 1551]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +20,4,number,19,"[1028, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +21,0,paragraph_title,Journal Pre-proof,"[475, 52, 714, 82]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p21 y=52/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +21,1,text,"6B), increased ERK phosphorylation (Fig. 5F-G) and, accordingly, enhanced","[83, 103, 907, 131]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,2,text,"chondrogenesis. By direct contrast, X-directed PEMFs applied to the RND scaffolds","[84, 159, 981, 186]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,3,text,"increased FAK activation, decreased ERK phosphorylation (Fig. 6G), pro","[84, 213, 970, 240]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,4,text,detectable change in YAP localisation (Fig. 6B) and inhibited MSC chondrogenesis. Since,"[84, 268, 1047, 295]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,5,text,neither the macroscopic mechanical environment nor amplitude of the magnetic fields,"[84, 323, 1004, 351]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,6,text,"differ in the distinct orientations, differences in cell sheet spreading in the horizontal (plane","[85, 378, 1051, 406]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,7,text,of the dish) and vertical planes are the most likely variable to account for the detected,"[84, 434, 1001, 461]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,8,text,difference (Fig. 1B). These results reveal an interplay between magnetic field directionality,"[85, 489, 1049, 517]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,9,text,"and the mechanical preconditioning conferred by fibrous scaffolds, mediated via","[84, 544, 941, 572]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,10,text,cytoskeleton dynamics involving the FAK/ERK/YAP signalling axis.,"[86, 600, 802, 627]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,11,text,Mitochondrial interplay between mechanotransduction and magnetoreception,"[86, 666, 913, 694]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,12,text,"We have previously demonstrated that PEMFs induce calcium entry through transient receptor potential (TRPC1) channels [24], promoting both in vitro chondrogenesis [23] and myogenesis [31] by activatin","[84, 735, 1051, 925]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,13,text,"mechanotransduction [55] and magnetoreception [23,31], which, in turn, would influence cytoskeletal remodelling and associated mechanotransduction [56]. On another level, mitochondrial activation and ","[83, 957, 1025, 1148]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,14,text,"[57,58]. It is thus consistend with available evidence that mechanotransduction and","[85, 1175, 974, 1203]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,15,paragraph_title,"magnetoreception interact via a mutual impingement upon mitochondrial respiration. Here,","[85, 1232, 1051, 1260]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: magnetoreception interact via a mutual impingement upon mito""]",subsection_heading,0.6,body_zone,body_like,none,True,True +21,16,text,we show that PEMF directionality differentially modulates mitochondrial respiration in,"[84, 1286, 993, 1314]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,17,paragraph_title,MSCs undergoing chondrogenesis. Z-directed PEMFs applied to MSCs on the RND scaffolds moderately stimulated basal respiration that correlated with enhanced,"[85, 1340, 983, 1424]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: MSCs undergoing chondrogenesis. Z-directed PEMFs applied to ""]",subsection_heading,0.6,body_zone,body_like,none,True,True +21,18,footer,,"[85, 1396, 934, 1424]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +21,19,text,"chondrogenic outcome, whereas X-directed PEMFs produced more exaggerated","[85, 1452, 950, 1480]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,20,text,increases respiratory capacities (Fig. 8) that instead coincided with compromised,"[85, 1507, 952, 1535]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +21,21,number,20,"[1026, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +22,0,header,Journal Pre-proof,"[475, 53, 714, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p22 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +22,1,text,"chondrogenic induction (Fig. 4A). Subtle differences in ROS levels have been shown to have disparate effects on MSC-derived chondogenesis [57–59]. For instance, whereas NADPH oxidases-generated ROS ar","[86, 82, 1051, 898]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,2,paragraph_title,"TRPC1 is activated by ROS [66] and conversely, TRPC1-mediated calcium entry","[85, 943, 951, 971]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: TRPC1 is activated by ROS [66] and conversely, TRPC1-mediate""]",section_heading,0.6,body_zone,body_like,none,True,True +22,3,paragraph_title,"mitohormesis [31]. FAK staining indicates that resting cytoskeletal tensions of MSCs are least on the RND scaffolds and highest on TCP (Fig. 5B, D-E). Accepting that PEMF","[84, 1164, 1030, 1247]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: mitohormesis [31]. FAK staining indicates that resting cytos""]",section_heading,0.6,body_zone,body_like,none,True,True +22,4,footer,,"[85, 1219, 987, 1247]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +22,5,text,"exposure and resting mechanotransduction act cumulatively in a mitohormetic fashion,","[85, 1275, 1010, 1301]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,6,paragraph_title,increases and decreases (excessive mitochondrial activation) in FAK phosphorylation in response to magnetic exposure of fixed amplitude substantiates pre-existing low and high,"[85, 1330, 1043, 1412]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: increases and decreases (excessive mitochondrial activation)""]",subsection_heading,0.6,body_zone,body_like,none,True,True +22,7,footer,,"[85, 1385, 1043, 1412]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False +22,8,text,"levels of resting mechanical tension, respectively, correspondent to X-directed PEMFs","[87, 1440, 1009, 1467]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,9,text,applied to MSCs on the RND scaffolds and Z-directed PEMFs applied to MSCs on TCP,"[85, 1494, 1022, 1522]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +22,10,number,21,"[1026, 1561, 1054, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +23,0,paragraph_title,Journal Pre-proof,"[476, 53, 713, 82]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p23 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +23,1,text,"(Fig. 5D-E). It must be stipulated, however, that these results are cumulative, representing the combined mitochondrial responses of cytoskeletal-based mechanotransduction in conjunction with those in","[84, 88, 1052, 458]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,2,paragraph_title,Influence of magnetic field directionality,"[86, 501, 513, 528]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Influence of magnetic field directionality""]",subsection_heading,0.6,body_zone,heading_like,none,True,True +23,3,text,Previous studies have demonstrated an anisotropic relationship between magnetic field direction and induced mitochondrial respiration [67]. Having shown that similar PEMFs to those employed in present,"[85, 578, 1049, 1501]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,4,text,maxima and minima: 1) cells plated in 2D in the X-Y plane in response to Z-directed fields,"[85, 1507, 1047, 1535]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +23,5,number,22,"[1026, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +24,0,header,Journal Pre-proof,"[476, 53, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p24 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +24,1,text,"and; 2) Y-aligned cells exposed to Y-directed fields, respectively, in accordance with this +proposed mechanism.","[84, 101, 1029, 186]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,2,paragraph_title,5. Conclusion,"[84, 226, 259, 252]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True +24,3,text,Chondrogenic responses to PEMF exposure were modulated by both micromechanical environment as well as the degree of cross-alignment of cells with the fields. Our results indicate that the efficacy of ,"[83, 281, 1045, 643]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,4,paragraph_title,Acknowledgements,"[85, 789, 318, 818]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True +24,5,text,This work was supported by funding from Singapore Ministry of Education (MOE2019-T2-1-127). CC was supported by the National University of Singapore Research Scholarship.,"[85, 845, 1042, 929]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,6,text,"Authors' contributions: CC conducted all experimental work, data acquisition and analyses, interpretation of data as well as the manuscript writing. AF-O provided the PEMF device and expertise, interp","[83, 1011, 1058, 1262]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,7,text,"Conflicts of interest statement: AF-O is an inventor on patent WO 2019/17863 A1, System and Method for Applying Pulsed Electromagnetic Fields, wherein field directionality effects are described, as we","[83, 1340, 1006, 1537]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True +24,8,number,23,"[1027, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +25,0,header,Journal Pre-proof,"[475, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p25 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +25,1,text,conflicts of interest.,"[84, 102, 296, 130]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True +25,2,number,24,"[1025, 1560, 1057, 1585]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False +26,0,header,Journal Pre-proof,"[475, 53, 713, 80]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p26 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +26,1,paragraph_title,References,"[85, 102, 222, 128]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True +26,2,reference_content,"[1] M. 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(A) SEM micrographs. Segments presented as red indicates pores within the fibres. 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(A) Relative expression of chondrogenic markers on TCP, RND and ALN in response to PEMF exposure. MSCs on the different topographies","[83, 103, 1055, 1076]",figure_caption,0.9,"[""figure caption candidate (body narrative): Fig. 3 Optimisation of PEMFs on the different surface topogr""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +33,2,number,32,"[1026, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +34,0,figure_title,A,"[89, 97, 116, 125]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +34,1,figure_title,Journal Pre-proof,"[476, 51, 714, 82]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p34 y=51/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +34,2,chart,,"[93, 108, 421, 319]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,3,figure_title,COL I/COL II,"[243, 316, 323, 335]",figure_caption_candidate,0.85,"[""figure_title label: COL I/COL II""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +34,4,chart,,"[432, 111, 731, 310]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,5,figure_title,COL X/COL II,"[551, 317, 637, 335]",figure_caption_candidate,0.85,"[""figure_title label: COL X/COL II""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +34,6,chart,,"[741, 111, 1050, 309]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,7,chart,,"[92, 329, 418, 511]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,8,chart,,"[423, 334, 731, 510]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,9,figure_title,B,"[90, 509, 115, 534]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +34,10,chart,,"[760, 357, 1054, 457]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,11,figure_title,"RND +ACAN","[556, 527, 619, 578]",figure_caption_candidate,0.85,"[""figure_title label: RND\nACAN""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +34,12,image,,"[89, 524, 1054, 1000]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +34,13,figure_title,C,"[89, 1002, 115, 1028]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +34,14,chart,,"[88, 1023, 439, 1222]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,15,chart,,"[449, 1015, 744, 1222]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,16,chart,,"[756, 1022, 1050, 1220]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +34,17,figure_title,"Fig. 4 Effect of directional PEMF on MSC chondrogenesis on different topographies. (A) Real-time PCR analysis of cartilaginous, fibroblastic and hypertrophic markers' expression after 14 days of diffe","[83, 1267, 1059, 1522]",figure_caption,0.92,"[""figure_title label: Fig. 4 Effect of directional PEMF on MSC chondrogenesis on d""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +34,18,number,33,"[1026, 1561, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +35,0,header,Journal Pre-proof,"[476, 52, 712, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p35 y=52/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +35,1,text,"2 independent experiments. (B) Immunofluorescent staining for COL II, ACAN and COL I deposition on TCP, RND and ALN in response to PEMFs at Day 21 of differentiation. Scale bar represents 20 μm and ap","[83, 101, 1059, 466]",reference_item,0.78,"[""default body_paragraph for text label"", ""late role resolution: non-body family 'reference_like' overrides body_paragraph"", ""style_family_authority=reference_marker"", ""context_source=block""]",body_paragraph,0.6,reference_zone,reference_like,reference_numeric_dot,True,True +35,2,chart,,"[87, 509, 282, 1231]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +35,3,figure_title,B,"[282, 508, 298, 528]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +35,4,figure_title,C,"[456, 507, 473, 530]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +35,5,chart,,"[291, 510, 457, 1228]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +35,6,chart,,"[457, 509, 830, 1230]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +35,7,chart,,"[836, 517, 1046, 1230]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +35,8,figure_title,"Fig. 5 Transient effects of directional PEMFs on pFAK in MSCs laden on TCP, RND and ALN. (A) Cell morphology under different conditions (green ≡ phalloidin). (B) pFAK probing by IFS (red ≡ pFAK; yello","[84, 1282, 1058, 1535]",figure_caption,0.92,"[""figure_title label: Fig. 5 Transient effects of directional PEMFs on pFAK in MSC""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +35,9,number,34,"[1026, 1561, 1056, 1585]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +36,0,paragraph_title,Journal Pre-proof,"[475, 52, 714, 82]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p36 y=52/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +36,1,text,"15. (F) Western blot analysis for the effect of directional PEMFs on the activation of FAK, ERK and P38 expression in MSCs on different topographies at 1hPP. (G) Semiquantification of phosphorylated F","[84, 101, 1058, 410]",reference_item,0.6,"[""reference-like pattern: 15. 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(A) YAP probing by IFS (green ≡ YAP; yellow dashes ≡ cell boundary; white dashes ≡ nuclei boundary; sc","[84, 102, 1058, 631]",figure_caption,0.9,"[""figure caption candidate (body narrative): Fig. 6 of directional PEMFs on YAP localisation and expressi""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True +38,2,number,37,"[1026, 1561, 1055, 1584]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +39,0,paragraph_title,Journal Pre-proof,"[475, 52, 714, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p39 y=52/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +39,1,figure_title,A,"[83, 96, 118, 128]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,2,image,,"[104, 125, 597, 446]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +39,3,figure_title,B,"[646, 96, 676, 126]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,4,chart,,"[655, 119, 1035, 353]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +39,5,chart,,"[138, 458, 583, 640]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +39,6,chart,,"[673, 384, 1037, 597]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +39,7,figure_title,COL II,"[347, 668, 409, 693]",figure_caption_candidate,0.85,"[""figure_title label: COL II""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +39,8,figure_title,C,"[85, 646, 116, 678]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,9,chart,,"[97, 687, 583, 952]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +39,10,figure_title,D,"[84, 953, 117, 984]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,11,chart,,"[590, 671, 1045, 949]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +39,12,image,,"[128, 973, 563, 1249]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True +39,13,figure_title,E,"[585, 953, 612, 985]",figure_inner_text,0.9,"[""panel label / figure inner text: E""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True +39,14,chart,,"[597, 985, 1053, 1239]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +39,15,figure_title,Fig. 7 Role of pFAK signalling in transducing PEMF effect to MSC chondrogenesis on RND fibrous scaffolds. (A) Western blot analysis of FAK and ERK protein phosphorylation measured 1-hour following PEM,"[80, 1301, 1058, 1554]",figure_caption,0.92,"[""figure_title label: Fig. 7 Role of pFAK signalling in transducing PEMF effect to""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +39,16,number,38,"[1026, 1560, 1056, 1584]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +40,0,header,Journal Pre-proof,"[475, 53, 714, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p40 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +40,1,text,"COL II and ACAN by PEMF-treated MSCs in the presence (red bars) or absence of FAK inhibitor (blue bars). Data shown represent means ± SD, n = 6 from 2 independent experiments. (D) Protein semi-quantif","[84, 99, 1059, 578]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,,unknown_like,none,True,True +40,2,number,39,"[1026, 1561, 1055, 1583]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +41,0,header,Journal Pre-proof,"[475, 52, 713, 82]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p41 y=52/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +41,1,figure_title,Spare respiratory capacity,"[144, 118, 393, 146]",figure_caption,0.85,"[""figure_title label: Spare respiratory capacity""]",figure_caption,0.85,,unknown_like,none,True,True +41,2,chart,,"[103, 155, 389, 425]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,3,figure_title,Basal respiration rate,"[498, 119, 701, 146]",figure_caption_candidate,0.85,"[""figure_title label: Basal respiration rate""]",figure_caption,0.85,,unknown_like,none,False,False +41,4,chart,,"[432, 129, 713, 426]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,5,figure_title,Maximal respiration,"[840, 118, 1024, 146]",figure_caption_candidate,0.85,"[""figure_title label: Maximal respiration""]",figure_caption,0.85,,unknown_like,short_fragment,False,False +41,6,chart,,"[767, 124, 1043, 423]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,7,figure_title,ATP-coupled $ O_{2} $ consumption,"[127, 468, 409, 496]",figure_caption_candidate,0.85,"[""figure_title label: ATP-coupled $ O_{2} $ consumption""]",figure_caption,0.85,,unknown_like,none,False,False +41,8,figure_title,Non-ATP-coupled $ O_{2} $ consumption,"[434, 468, 763, 496]",figure_caption,0.85,"[""figure_title label: Non-ATP-coupled $ O_{2} $ consumption""]",figure_caption,0.85,,legend_like,none,True,True +41,9,chart,,"[103, 505, 398, 775]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,10,chart,,"[431, 505, 749, 778]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,11,chart,,"[852, 443, 1055, 702]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,,unknown_like,empty,True,True +41,12,figure_title,"Fig. 8 Role of inhibition of FAK (red bars) on cellular respiration on the RND scaffolds. Data shown represent means ± SD, n = 6 from 2 independent experiments. * denotes significance levels compared ","[83, 841, 1037, 1152]",figure_caption,0.92,"[""figure_title label: Fig. 8 Role of inhibition of FAK (red bars) on cellular resp""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True +41,13,number,40,"[1027, 1560, 1056, 1585]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False +42,0,header,Journal Pre-proof,"[475, 53, 713, 81]",frontmatter_noise,0.98,"[""journal pre-proof running header suppressed: p42 y=53/1684""]",frontmatter_noise,0.98,preproof_cover_zone,unknown_like,preproof_marker,False,False +42,1,figure_title,Table 1 Nomenclature of test groups.,"[85, 159, 422, 186]",table_caption,0.9,"[""table prefix matched: Table 1 Nomenclature of test groups.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True +42,2,table,"0.68), LAA (≤83°), and CSA (≥35°). The area under the ROC curve was highest for the CSA (0.855 vs","[100, 1329, 590, 1450]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,8,text,"CSA is the most valuable measure for discriminating be- +tween the RCT and control groups (Figs. 2 and 3). This was +also reflected in the calculated sensitivity and specificity, +which were revealed to be","[624, 948, 1117, 1209]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +3,9,paragraph_title,Discussion,"[629, 1250, 745, 1276]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True +3,10,text,"The influence of individual scapular morphology on the pathogenesis of RCTs remains controversial. Although some authors place great importance on anatomic variants, particularly those of the acromion","[625, 1305, 1116, 1450]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True +4,0,number,4,"[74, 66, 89, 86]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,1,header,ARTICLE IN PRESS,"[413, 5, 679, 36]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False +4,2,header,B.K. Moor et al.,"[948, 64, 1082, 88]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False +4,3,figure_title,Table I Linear and logistic regression analysis for each parameter,"[83, 121, 593, 144]",figure_caption_candidate,0.85,"[""figure_title label: Table I Linear and logistic regression analysis for each par""]",figure_caption,0.85,,reference_like,citation_line,False,False +4,4,table,"
TopographyPEMF amplitude (mT)PEMF directionPlot abbreviation
Tissue culture plastic (TCP)0N/ANP
None: def test_non_backmatter_zone_not_affected() -> None: - """Blocks outside post_reference_backmatter_zone are not converted.""" + """Blocks outside verified reference zone are HOLD by structural gate.""" from paperforge.worker.ocr_document import normalize_document_structure blocks = [ @@ -4694,8 +4694,12 @@ def test_non_backmatter_zone_not_affected() -> None: ] doc, normalized = normalize_document_structure(blocks) by_id = {b["block_id"]: b for b in normalized} - # No zone set -> not in post_reference_backmatter_zone -> stays reference_item - assert by_id["bio_1"]["role"] == "reference_item" + # Verified reference zone correctly excludes bio_1 (page 11, not in zone). + # Structural gate HOLDs it as unknown_structural with role_candidate retained. + assert by_id["bio_1"]["role"] == "unknown_structural" + assert by_id["bio_1"]["role_candidate"] == "reference_item" + # Ref items inside verified zone remain accepted. + assert by_id["r1"]["role"] == "reference_item" def test_sanitize_reference_zone_boundary_strips_non_reference_roles() -> None: @@ -4838,3 +4842,104 @@ def test_rendered_text_coverage_flags_missing_pdf_segment() -> None: ) assert result["rendered_text_gap_count"] == 1 + + +def test_compute_layout_facts_marks_reading_band_region_boundary_and_bridge() -> None: + from paperforge.worker.ocr_document import compute_layout_facts + + blocks = [ + { + "block_id": "body_1", + "page": 5, + "role": "body_paragraph", + "zone": "body_zone", + "bbox": [80, 120, 520, 220], + "text": "Body text.", + }, + { + "block_id": "ref_1", + "page": 5, + "role": "reference_item", + "zone": "reference_zone", + "bbox": [610, 120, 1120, 180], + "text": "Smith J, Doe P. J Bone Miner Res. 2021;36(4):100-110.", + }, + { + "block_id": "gap_1", + "page": 5, + "role": "unknown_structural", + "zone": "display_zone", + "bbox": [640, 200, 1110, 360], + "text": "", + }, + ] + + facts = compute_layout_facts(blocks) + by_id = {row["block_id"]: row for row in facts} + + assert by_id["body_1"]["layout_region"] == "body_flow" + assert by_id["ref_1"]["layout_region"] == "reference_candidate" + assert by_id["body_1"]["reading_band_id"] != by_id["ref_1"]["reading_band_id"] + assert by_id["gap_1"]["bridge_eligible"] is True + assert by_id["ref_1"]["boundary_before"] in {"weak", "hard"} + + +def test_reference_signal_detector_scores_unnumbered_vancouver_entry() -> None: + from paperforge.worker.ocr_reference_signals import score_reference_entry + + result = score_reference_entry( + "Smith J, Doe P. Bone regeneration with scaffold support. J Bone Miner Res. 2021;36(4):100-110. doi:10.1000/test" + ) + + assert result["family"] == "vancouver_structured_unnumbered" + assert result["confidence"] > 0.6 + assert result["signals"]["journal_lexicon_match"] is True + + +def test_reference_signal_detector_distinguishes_report_like_entry() -> None: + from paperforge.worker.ocr_reference_signals import score_reference_entry + + result = score_reference_entry( + "World Health Organization. Clinical management guideline [Internet]. 2023 [cited 2024 Jan 10]. Available from: https://example.org" + ) + + assert result["family"] == "book_or_report" + assert result["signals"]["online_marker_signature"] is True + + +def test_reference_corridor_keeps_reference_like_blocks_but_rejects_acknowledgements() -> None: + from paperforge.worker.ocr_document import score_reference_corridor_membership + + ref_block = { + "block_id": "r1", + "page": 20, + "role": "reference_item", + "zone": "reference_zone", + "layout_region": "reference_candidate", + "text": "Brown T, Green S. N Engl J Med. 2020;382(4):100-110.", + } + ack_block = { + "block_id": "a1", + "page": 20, + "role": "backmatter_body", + "zone": "tail_nonref_hold_zone", + "layout_region": "tail_candidate", + "text": "Acknowledgements We thank the patients and families.", + } + + ref_score = score_reference_corridor_membership(ref_block) + ack_score = score_reference_corridor_membership(ack_block) + + assert ref_score["accept_reference_membership"] is True + assert ack_score["accept_reference_membership"] is False + assert ack_score["non_ref_intrusion_score"] > ref_score["non_ref_intrusion_score"] + + +def test_reference_hold_does_not_promote_final_reference_membership() -> None: + from paperforge.worker.ocr_structural_gate import build_verified_reference_zone_from_artifacts + + blocks = [ + {"block_id": "x1", "role": "backmatter_body", "zone": "tail_nonref_hold_zone", "text": "Data availability statement."}, + ] + zone = build_verified_reference_zone_from_artifacts(blocks, {"region_bus": {"reference_zone_ids": set()}}) + assert zone.get("status") != "ACCEPT" diff --git a/tests/test_ocr_layout_zones.py b/tests/test_ocr_layout_zones.py index 071d775f..cd8061db 100644 --- a/tests/test_ocr_layout_zones.py +++ b/tests/test_ocr_layout_zones.py @@ -183,3 +183,17 @@ def test_analyze_document_structure_computes_region_bus_before_role_normalizatio assert "p7_b2" not in doc.region_bus["body_zone"]["block_ids"] assert "p8_b2" in doc.region_bus["reference_zone"]["block_ids"] assert "p8_b3" in doc.region_bus["reference_zone"]["block_ids"] + + +def test_layout_facts_split_body_and_reference_candidates_on_same_page() -> None: + from paperforge.worker.ocr_document import compute_layout_facts + + blocks = [ + {"block_id": "b1", "page": 12, "role": "body_paragraph", "zone": "body_zone", "bbox": [70, 100, 540, 160], "text": "Conclusion paragraph."}, + {"block_id": "r1", "page": 12, "role": "reference_item", "zone": "reference_zone", "bbox": [620, 100, 1110, 150], "text": "Brown T. Lancet. 2020;395:10-12."}, + ] + + facts = {row["block_id"]: row for row in compute_layout_facts(blocks)} + assert facts["b1"]["layout_region"] == "body_flow" + assert facts["r1"]["layout_region"] == "reference_candidate" + assert facts["b1"]["reading_band_id"] != facts["r1"]["reading_band_id"] diff --git a/tests/test_ocr_pdf_text_fallback.py b/tests/test_ocr_pdf_text_fallback.py index d90680a2..64bee11b 100644 --- a/tests/test_ocr_pdf_text_fallback.py +++ b/tests/test_ocr_pdf_text_fallback.py @@ -120,3 +120,17 @@ def test_backfill_requires_page_dimensions(tmp_path: Path): assert blocks[0]["_ocr_raw_status"] == "missing_text_unrecovered" assert blocks[0]["_ocr_raw_error_type"] == "missing_page_dimensions" + + +def test_local_reference_pdf_fallback_repairs_only_local_candidate_text() -> None: + from paperforge.worker.ocr_document import repair_reference_entry_from_pdf_text + + block_run = [ + {"block_id": "r1", "page": 14, "bbox": [620, 900, 1100, 950], "text": "Brown T, Green S."}, + {"block_id": "r2", "page": 14, "bbox": [620, 952, 1100, 1000], "text": "N Engl J M"}, + ] + page_text = "Body text ... Brown T, Green S. N Engl J Med. 2020;382(4):100-110. More body text" + + repaired = repair_reference_entry_from_pdf_text(block_run, page_text) + assert "N Engl J Med" in repaired + assert repaired.startswith("Brown T, Green S.") diff --git a/tests/test_ocr_structural_gate.py b/tests/test_ocr_structural_gate.py index 69a0e1ed..df92e891 100644 --- a/tests/test_ocr_structural_gate.py +++ b/tests/test_ocr_structural_gate.py @@ -215,6 +215,74 @@ def test_reference_zone_accepts_heading_when_region_ids_are_plain_block_ids() -> assert zone["item_block_ids"] == [11] +def test_ordered_reference_anchors_do_not_swallow_non_ref_blocks_between_anchors() -> None: + from paperforge.worker.ocr_structural_gate import _build_ordered_reference_items + + blocks = [ + {"page": 14, "block_id": 11, "seed_role": "reference_item", "bbox": [620, 500, 1100, 520], "text": "Smith J. 2020."}, + {"page": 14, "block_id": 12, "seed_role": "body_paragraph", "bbox": [620, 530, 1100, 600], "text": "A long body paragraph that does not belong in references."}, + {"page": 14, "block_id": 13, "seed_role": "reference_item", "bbox": [620, 610, 1100, 630], "text": "Brown T. 2021."}, + ] + anchor_ids = {11, 13} + result = _build_ordered_reference_items(blocks, anchor_ids, set()) + assert 11 in result + assert 13 in result + assert 12 not in result + + +def test_ordered_reference_anchors_fill_reference_like_gap_but_not_intrusion() -> None: + from paperforge.worker.ocr_structural_gate import _build_ordered_reference_items + + blocks = [ + {"page": 20, "block_id": 1, "seed_role": "reference_item", "bbox": [80, 500, 520, 520], "text": "Ref [1]."}, + {"page": 20, "block_id": 2, "seed_role": "reference_item", "bbox": [80, 525, 520, 545], "text": "Continuation line of ref [1]."}, + {"page": 20, "block_id": 3, "seed_role": "reference_item", "bbox": [80, 550, 520, 570], "text": "Ref [2]."}, + ] + anchor_ids = {1, 3} + result = _build_ordered_reference_items(blocks, anchor_ids, set()) + assert 1 in result + assert 3 in result + assert 2 in result + + +def test_ordered_reference_anchors_stop_at_section_heading() -> None: + from paperforge.worker.ocr_structural_gate import _build_ordered_reference_items + + blocks = [ + {"page": 14, "block_id": 11, "seed_role": "reference_item", "bbox": [620, 500, 1100, 520], "text": "Smith J. 2020."}, + {"page": 14, "block_id": 12, "seed_role": "section_heading", "bbox": [620, 530, 1100, 550], "text": "Data Availability"}, + {"page": 14, "block_id": 13, "seed_role": "reference_item", "bbox": [620, 560, 1100, 580], "text": "Brown T. 2021."}, + ] + anchor_ids = {11, 13} + result = _build_ordered_reference_items(blocks, anchor_ids, set()) + assert 11 in result + assert 13 in result + assert 12 not in result + + +def test_ordered_reference_anchors_rejects_acknowledgement_swallowed_as_gap() -> None: + from paperforge.worker.ocr_structural_gate import build_verified_reference_zone_from_artifacts + + blocks = [ + {"page": 14, "block_id": "refs", "seed_role": "reference_heading", "text": "References"}, + {"page": 14, "block_id": "r1", "seed_role": "reference_item", "bbox": [80, 120, 520, 140], "text": "[1] Smith J. 2020."}, + {"page": 14, "block_id": "ack", "seed_role": "backmatter_body", "bbox": [80, 160, 520, 200], "text": "Acknowledgements We thank the funding agency."}, + {"page": 14, "block_id": "r2", "seed_role": "reference_item", "bbox": [80, 220, 520, 240], "text": "[2] Brown T. 2021."}, + ] + zone = build_verified_reference_zone_from_artifacts( + blocks, + { + "reference_family_anchor": {"heading_block_id": "refs", "item_block_ids": ["r1", "r2"]}, + "region_bus": {"reference_zone_ids": {"refs", "r1", "r2"}}, + "tail_spread": {}, + }, + ) + assert zone["status"] == "ACCEPT" + assert "r1" in zone["item_block_ids"] + assert "r2" in zone["item_block_ids"] + assert "ack" not in zone["item_block_ids"] + + def test_abstract_body_without_span_is_not_verified_accept() -> None: from paperforge.worker.ocr_structural_gate import RoleGateContext, resolve_verified_role diff --git a/tests/test_ocr_tables.py b/tests/test_ocr_tables.py index 4bfc05f3..8e6c74f5 100644 --- a/tests/test_ocr_tables.py +++ b/tests/test_ocr_tables.py @@ -1078,3 +1078,18 @@ def test_bare_table_number_can_match_previous_page_continuation_under_strong_geo assert table["match_status"] in {"matched_low_confidence", "matched"} assert table["asset_block_id"] == "p7_a1" + + +def test_table_inventory_keeps_bridge_gap_inside_sparse_display_cluster() -> None: + from paperforge.worker.ocr_tables import build_table_inventory + + structured_blocks = [ + {"page": 10, "block_id": "table_asset", "role": "table_asset", "raw_label": "table", "bbox": [100, 120, 620, 420], "text": "", "layout_region": "display_zone"}, + {"page": 10, "block_id": "gap_block", "role": "unknown_structural", "bbox": [640, 130, 930, 420], "text": "", "layout_region": "display_zone", "bridge_eligible": True}, + {"page": 10, "block_id": "table_caption", "role": "table_caption", "bbox": [120, 450, 900, 490], "text": "Table 1. Sparse reconstruction.", "layout_region": "display_zone"}, + ] + + inventory = build_table_inventory(structured_blocks) + table = inventory["tables"][0] + assert table["asset_block_id"] == "table_asset" + assert table.get("bridge_block_ids") == ["gap_block"]
CTRL (n = 51)RCT (n = 51)Unadjusted difference (95% confidence interval, P value)
AI0.66 (0.6-0.72)0.74 (0.71-0.79)