obsidian-plugin/lllin000_PaperForge
1
0
Fork 0
mirror of https://github.com/lllin000/PaperForge.git synced 2026-07-22 06:50:53 +00:00
Code Issues Projects Releases Packages Wiki Activity Actions

fix: heading detection, backmatter, table consumed, footnote reorder, figure crop + audit fixtures

Browse source
This commit is contained in:
Research Assistant 2026-06-22 01:28:55 +08:00
parent 924fcfd54f
commit 4cd0cf3d54
587 changed files with 379245 additions and 40955 deletions
Show stats Download patch file Download diff file Expand all files Collapse all files

9
.opencode/opencode.json Normal file
View file

@ -0,0 +1,9 @@
{
"$schema": "https://opencode.ai/config.json",
"skills": {
"paths": [
".opencode/skills",
"C:/Users/Lin/ponytail/skills"
]
}
}

16
_amb_detail.py Normal file
View file

@ -0,0 +1,16 @@
import json; from pathlib import Path
audit=Path('audit')
papers=['6QNRHRKX','7S5ZEVSK','8K39NHUQ','5DIEAVPW','RKSLQRIM']
for k in papers:
fp=audit/k/'figure_table_ownership_summary.json'
if not fp.exists(): continue
d=json.load(open(fp,'r',encoding='utf-8'))
print(f'\n=== {k} ===')
matched=d['figures']['matched_count']; amb=d['figures']['ambiguous_count']
print(f'fig={matched}/{matched+amb}')
for a in d['figures'].get('ambiguous',[]):
fn=a.get('figure_number','?')
ca=len(a.get('candidate_asset_ids',[]))
hr=a.get('hold_reason','?')
pg=a.get('page','?')
print(f' Fig {fn} p{pg}: {ca}cand {hr}')

23
_chk_pdf.py Normal file
View file

@ -0,0 +1,23 @@
import json
from pathlib import Path
for paper in ['RKSLQRIM', '6DIINFHX', 'GTRPMM56', 'KIX7SKXQ']:
meta_path = Path(f'D:/L/OB/Literature-hub/System/PaperForge/ocr/{paper}/raw/source_metadata.json')
if not meta_path.exists():
print(f'{paper}: NO METADATA')
continue
meta = json.load(open(meta_path,'r',encoding='utf-8'))
src = meta.get('source_pdf','')
exists = Path(src).exists() if src else False
print(f'{paper}: pdf={src[:60]}... exists={exists}')
# Check backfill status on structured blocks
blk_path = Path(f'D:/L/OB/Literature-hub/System/PaperForge/ocr/{paper}/structure/blocks.structured.jsonl')
if blk_path.exists():
lines = [json.loads(l) for l in blk_path.read_text(encoding='utf-8').strip().split('\n') if l.strip()]
empty_us = [b for b in lines if b.get('role','')=='unknown_structural' and len(str(b.get('text','') or ''))==0]
recovered = sum(1 for b in lines if b.get('_ocr_raw_status')=='missing_text_recovered')
print(f' empty unknown_structural: {len(empty_us)}, recovered: {recovered}')
if empty_us:
b = empty_us[0]
print(f' sample: p{b.get("page")}:{b.get("block_id")} raw_label={b.get("raw_label")} spans={len(b.get("span_metadata",[]))} status={b.get("_ocr_raw_status")}')

36
_chk_vfs_p11.py Normal file
View file

@ -0,0 +1,36 @@
import json
with open('D:/L/OB/Literature-hub/System/PaperForge/ocr/VFS8CBW2/structure/blocks.structured.jsonl','r',encoding='utf-8') as f:
lines = [json.loads(l) for l in f.read().strip().split('\n') if l.strip()]
p11 = [b for b in lines if b.get('page')==11]
p10 = [b for b in lines if b.get('page')==10]
p12 = [b for b in lines if b.get('page')==12]
print('=== PAGE 10 ===')
for b in p10:
bid = b['block_id']
role = b.get('role','?')
txt = str(b.get('text','') or '')[:80]
bbox = b.get('bbox',[])
print(f' id={bid:3d} role={role:25s} text_len={len(txt):4d} bbox={bbox}')
if txt:
print(f' [{txt}]')
print('\n=== PAGE 11 ===')
for b in p11:
bid = b['block_id']
role = b.get('role','?')
txt = str(b.get('text','') or '')[:80]
bbox = b.get('bbox',[])
print(f' id={bid:3d} role={role:25s} text_len={len(txt):4d} bbox={bbox}')
if txt:
print(f' [{txt}]')
print('\n=== PAGE 12 ===')
for b in p12:
bid = b['block_id']
role = b.get('role','?')
txt = str(b.get('text','') or '')[:80]
bbox = b.get('bbox',[])
print(f' id={bid:3d} role={role:25s} text_len={len(txt):4d} bbox={bbox}')
if txt:
print(f' [{txt}]')

5
_figmap.json Normal file
View file

@ -0,0 +1,5 @@
Traceback (most recent call last):
File "D:\L\Med\Research\99_System\LiteraturePipeline\github-release\.opencode\skills\paperforge-development\scripts\audit_helpers.py", line 363, in <module>
"body_find_noise": body_find_noise,
^^^^^^^^^^^^^^^
NameError: name 'body_find_noise' is not defined

11
_final_stats.py Normal file
View file

@ -0,0 +1,11 @@
import json; from pathlib import Path
audit=Path('audit')
papers=sorted([d.name for d in audit.iterdir() if (d/'figure_table_ownership_summary.json').exists()])
total_fm=0; total_fa=0
for k in papers:
d=json.load(open(audit/k/'figure_table_ownership_summary.json','r',encoding='utf-8'))
fm=d['figures']['matched_count']; fa=d['figures']['ambiguous_count']
tm=d['tables']['matched_count']; ta=d['tables']['ambiguous_count']
total_fm+=fm; total_fa+=fa
print(f'{k:<10} fig={fm}/{fm+fa} tbl={tm}/{tm+ta}')
print(f'\nTotal: {total_fm}/{total_fm+total_fa} = {total_fm/(total_fm+total_fa)*100:.0f}%' if total_fm+total_fa else '')

23
_test_6qnr.py Normal file
View file

@ -0,0 +1,23 @@
import json, sys
sys.path.insert(0, '.')
from paperforge.worker.ocr_figures import build_figure_inventory
for paper in ['6QNRHRKX', 'KIX7SKXQ']:
with open(f'D:/L/OB/Literature-hub/System/PaperForge/ocr/{paper}/structure/blocks.structured.jsonl','r',encoding='utf-8') as f:
blocks = [json.loads(l) for l in f.read().strip().split('\n') if l.strip()]
result = build_figure_inventory(blocks)
mt = len(result.get('matched_figures', []))
amb = len(result.get('ambiguous_figures', []))
print(f'{paper}: matched={mt} ambiguous={amb}')
for a in result.get('ambiguous_figures',[]):
fn = a.get('figure_number','?')
hr = a.get('hold_reason','?')
ca = len(a.get('candidates',[]))
pg = a.get('page','?')
print(f' Fig {fn} p{pg}: {ca}cand {hr}')
for m in result.get('matched_figures',[]):
fn = m.get('figure_number','?')
pg = m.get('page')
n = len(m.get('matched_assets',[]))
fl = m.get('flags',[])
print(f' MATCHED Fig {fn} p{pg}: {n} assets {fl}')

500
audit/23T2B8ZX/audit_report.json Normal file
View file

@ -0,0 +1,500 @@
{
"paper_key": "23T2B8ZX",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:c32fd65809059c4d60a58c03dc0214b7cd98296e1833b4e4ad6d3541f7126f4f",
"meta_json_hash": "sha256:50e42ca68bf8335f835c284c730e287ca2e0cd779b8c68dce01cd1325cde210c",
"blocks_raw_hash": "sha256:3d9d3a7da7accaafef2001d26e28854468ff728eb2009df6d61f54491ad60d66",
"structured_blocks_hash": "sha256:8b229bfea197ea7c8b79c8be9b043750705529649dcfcbd0ec57490173bb693f",
"document_structure_hash": "sha256:308f35126bbd7fc9911bee46e8ba6b987a3437e767078b37de6a6e2e75527cfd",
"figure_inventory_hash": "sha256:75ad4c0d43cdf378683a83770400df9ca8ea36b29e247dec9639066a4abbe483",
"table_inventory_hash": "sha256:141154eeda3bec84c7ff75f0212677ec09f8f5022d61ac0fbdfd33d2156545c9",
"reader_figures_hash": "sha256:c4d23553428efdfb646416f775b8746e58bc9d94f23ec1b12a17eaff2f618652",
"resolved_metadata_hash": "sha256:56d2d3e6933b78ec7a2f48d0cb9f511bccb02dc78b22ad0b100a3c93f71476a8",
"fulltext_hash": "sha256:9394031ade6bd3e9b8cf9700fac1b40f895d9b6565b1e13fcbea3c1a9d9893fd",
"block_trace_hash": "sha256:073d5b641165df47d4f65e03ee466aac966ded767d1b2e0710d520922c57c068",
"annotated_pages": {
"page_001.png": "sha256:aae0ab6983ee4640bd147829411a6ee4334ddaeed09590aa3b837a5386855c96",
"page_002.png": "sha256:4bd9a08d9b6e077b2236e17c65bbaad285380f2863ffc203224857a89a070cda",
"page_003.png": "sha256:5f972f1fec848d38a758c6976628e87c98a454049a01f700a7027def9230260a",
"page_004.png": "sha256:37bafcf6679ff384b494abd9663e47601363bce3144802af1bc3a48354a47dec",
"page_005.png": "sha256:59a2e78affac040c56f8effec28e7655731355951c7abdb718b2d2a5e4b4580a",
"page_006.png": "sha256:1661ffe5eaba390f415694d88d7d3866a3cdeebe342bb3d631173261da6cbcea",
"page_007.png": "sha256:c6f35d4c383bf1e02a630af47f56e1f666e19ee5fd1a2a68fa30ebd529b652cd"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png"
]
},
"reviewed_pages": [
1,
2,
3,
4,
5,
6
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p2:0",
"p2:1",
"p2:2",
"p2:3",
"p2:4",
"p2:5",
"p2:6",
"p2:7",
"p2:8",
"p2:9",
"p2:10",
"p2:11",
"p2:12",
"p2:13",
"p2:14",
"p2:15",
"p2:16",
"p2:17",
"p2:18",
"p2:19",
"p2:20",
"p2:21",
"p2:22",
"p2:23",
"p2:24",
"p2:25",
"p2:26",
"p2:27",
"p2:28",
"p3:0",
"p3:1",
"p3:2",
"p3:3",
"p3:4",
"p3:5",
"p3:6",
"p3:7",
"p3:8",
"p3:9",
"p3:10",
"p3:11",
"p3:12",
"p3:13",
"p3:14",
"p3:15",
"p3:16",
"p4:0",
"p4:1",
"p4:2",
"p4:3",
"p4:4",
"p4:5",
"p4:6",
"p4:7",
"p4:8",
"p4:9",
"p4:10",
"p4:11",
"p4:12",
"p4:13",
"p5:0",
"p5:1",
"p5:2",
"p5:3",
"p5:4",
"p5:5",
"p5:6",
"p5:7",
"p5:8",
"p5:9",
"p5:10",
"p5:11",
"p5:12",
"p5:13",
"p5:14",
"p5:15",
"p5:16",
"p5:17",
"p5:18",
"p5:19",
"p6:0",
"p6:1",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p6:12",
"p6:13",
"p6:14",
"p6:15",
"p6:16",
"p6:17"
],
"findings": [
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:14"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:15"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:16"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:17"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:1"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:2"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:3"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:4"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:5"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:6"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:7"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:8"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:9"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:10"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:11"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:12"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:13"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:14"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p7:15"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:0",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:7",
"p1:8",
"p1:16",
"p1:18",
"p2:1",
"p2:2",
"p2:5",
"p2:7",
"p3:0",
"p3:1",
"p4:1",
"p4:2",
"p5:0",
"p5:1",
"p5:3"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

37
audit/23T2B8ZX/audit_report.md Normal file
View file

@ -0,0 +1,37 @@
# OCR Truth Audit Report - 23T2B8ZX
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 2, 3, 4, 5, 6]
- Reviewed blocks: 117
## Findings
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

624
audit/23T2B8ZX/audit_scope.json Normal file
View file

@ -0,0 +1,624 @@
{
"mode": "high-risk",
"selected_pages": [
1,
2,
3,
4,
5,
6
],
"required_block_ids": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p2:1",
"p2:5",
"p2:7",
"p3:3",
"p4:3",
"p4:5",
"p5:3",
"p5:4",
"p5:9",
"p5:10",
"p5:14",
"p6:1",
"p6:7",
"p6:14",
"p6:15",
"p6:16",
"p6:17"
],
"required_blocks": [
{
"block_id": "p1:0",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:1",
"page": 1,
"required_reason": [
"frontmatter",
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:2",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:3",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:4",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:5",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:6",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:7",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:8",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:9",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:10",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:11",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:12",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:13",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:14",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:15",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:16",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:17",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:18",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p2:1",
"page": 2,
"required_reason": [
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p2:5",
"page": 2,
"required_reason": [
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p2:7",
"page": 2,
"required_reason": [
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p3:3",
"page": 3,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:3",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:5",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:3",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:4",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:9",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:10",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:14",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:1",
"page": 6,
"required_reason": [
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:7",
"page": 6,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:14",
"page": 6,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:15",
"page": 6,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:16",
"page": 6,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:17",
"page": 6,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
}
],
"selected_page_requirements": [
{
"page": 1,
"must_review_page": true,
"required_block_count": 19
},
{
"page": 2,
"must_review_page": true,
"required_block_count": 3
},
{
"page": 3,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 4,
"must_review_page": true,
"required_block_count": 2
},
{
"page": 5,
"must_review_page": true,
"required_block_count": 5
},
{
"page": 6,
"must_review_page": true,
"required_block_count": 6
}
]
}

2824
audit/23T2B8ZX/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

159
audit/23T2B8ZX/block_trace.csv Normal file
View file

@ -0,0 +1,159 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,header,J Shoulder Elbow Surg (2018),"[104.0, 64.0, 305.0, 84.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,1,header_image,,"[106.0, 103.0, 216.0, 199.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True
1,2,header,ARTICLE IN PRESS,"[419.0, 9.0, 799.0, 51.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False
1,3,header,"JOURNAL OF
SHOULDER AND
ELBOW
SURGERY","[949.0, 79.0, 1110.0, 175.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,4,header,www.elsevier.com/locate/ymse,"[911.0, 191.0, 1115.0, 211.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,5,text,ORIGINAL ARTICLE,"[103.0, 248.0, 301.0, 276.0]",authors,0.6,"[""page-1 initial-lastname author byline: ORIGINAL ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True
1,6,doc_title,Predictive findings on magnetic resonance imaging in patients with symptomatic acromioclavicular osteoarthritis,"[101.0, 309.0, 826.0, 447.0]",paper_title,0.8,"[""page-1 zone title_zone: Predictive findings on magnetic resonance imaging in patient""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True
1,7,text,"Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $ ^{a} $, Robin E. Westerbeek, MD $ ^{c} $, Rosalie P.H. Derks, MD $ ^{c} $, Ellie B.M. Landman, PhD $ ^{a} $, Cornelis T. Koorevaar, MD, PhD","[102.0, 475.0, 1076.0, 542.0]",authors,0.8,"[""page-1 zone author_zone: Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True
1,8,text," $ ^{a} $Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, Deventer, The Netherlands
$ ^{b} $Department of Orthopaedic Surgery, University Medical Center, University of Groningen","[101.0, 570.0, 1069.0, 646.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{a} $Department of Orthopaedic Surgery and Traumatology, ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,9,abstract,Background: A magnetic resonance imaging (MRI) scan of the shoulder can have added value in diagnosing symptomatic osteoarthritis of the acromioclavicular (AC) joint. Specific MRI signs have been reco,"[113.0, 684.0, 880.0, 774.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,10,abstract,Methods: The MRI scans of 70 patients with symptomatic AC osteoarthritis were compared with those of 70 patients with subacromial pain syndrome and no clinical signs of symptomatic AC osteoarthritis. ,"[114.0, 774.0, 881.0, 887.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,11,abstract,"Results: The presence of inferior osteophytes, bone marrow edema, impression on the supraspinatus, and inferior joint distension was individually associated with symptomatic AC osteoarthritis. Bone ma","[114.0, 885.0, 880.0, 1038.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,12,abstract,"Conclusion: We identified predictive MRI signs in patients with symptomatic AC osteoarthritis. These findings, including bone marrow edema, inferior joint distension, and impression on the supraspinat","[114.0, 1038.0, 879.0, 1126.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,13,text,"Level of evidence: Level IV; Case-Control Design; Diagnostic Study
© 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.","[115.0, 1125.0, 731.0, 1171.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Level of evidence: Level IV; Case-Control Design; Diagnostic""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,14,text,Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow edema; impression on musculus supraspinatus; predictive findings,"[114.0, 1176.0, 879.0, 1221.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,15,footnote,"Approval of this study was obtained from the regional Medical Ethical Committee (METC Isala, No. 15.0222).","[101.0, 1303.0, 833.0, 1324.0]",footnote,0.7,"[""footnote label: Approval of this study was obtained from the regional Medica""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True
1,16,footnote," $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, PO Box 5001, NL-7400 GC Deventer, The Netherlands.","[102.0, 1321.0, 1116.0, 1366.0]",footnote,0.7,"[""footnote label: $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department o""]",footnote,0.7,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,17,footnote,E-mail address: ejdveen@gmail.com (E.J.D. Veen).,"[126.0, 1365.0, 464.0, 1385.0]",footnote,0.7,"[""footnote label: E-mail address: ejdveen@gmail.com (E.J.D. Veen).""]",footnote,0.7,frontmatter_main_zone,support_like,none,True,True
1,18,footer,1058-2746/$ - see front matter © 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved. https://doi.org/10.1016/j.jse.2018.01.001,"[102.0, 1407.0, 875.0, 1449.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
2,0,number,2,"[75.0, 65.0, 88.0, 85.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False
2,1,doc_title,ARTICLE IN PRESS,"[388.0, 10.0, 767.0, 51.0]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,frontmatter_side_zone,support_like,short_fragment,False,True
2,2,header,E.J.D. Veen et al.,"[937.0, 65.0, 1081.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False
2,3,text,"Degeneration of the acromioclavicular (AC) joint, with joint space narrowing and osteophyte formation, is part of the normal aging process. $ ^{[10,19]} $ In most of the general population, osteoarthr","[70.0, 109.0, 558.0, 373.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,4,text,"The diagnosis of symptomatic AC osteoarthritis is made by an accurate history, clinical examination, and additional radiodiagnostic imaging studies. Previous studies have debated the accuracy and reli","[70.0, 374.0, 557.0, 541.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,5,text,Previous research has shown that advanced signs of degeneration in the AC joint seen on the MRI scan are correlated with symptoms and that bone marrow edema is only observed in patients with symptomat,"[70.0, 542.0, 558.0, 685.0]",unknown_structural,0.8,"[""page-1 zone author_zone: Previous research has shown that advanced signs of degenerat""]",authors,0.8,body_zone,body_like,none,False,True
2,6,text,The aim of this study was to identify predictive MRI signs in patients with symptomatic AC osteoarthritis. We hypothesized that specific MRI signs would be found in patients with symptomatic AC osteoa,"[70.0, 685.0, 558.0, 783.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,7,paragraph_title,Materials and methods Design,"[72.0, 808.0, 310.0, 887.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Materials and methods Design""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,False,True
2,8,footer,,"[72.0, 860.0, 142.0, 887.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False
2,9,text,"This study had a retrospective, case-control, diagnostic study design and was conducted in a general teaching hospital with a specialized shoulder unit.","[70.0, 911.0, 557.0, 978.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,10,paragraph_title,Study population,"[71.0, 1005.0, 238.0, 1031.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Study population""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
2,11,text,A total of 140 patients were selected from the electronic patient files: 70 consecutive patients with clinical isolated symptomatic AC osteoarthritis (group 1) and 70 consecutive patients with chronic,"[70.0, 1054.0, 558.0, 1187.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,12,text,Patients in both groups were recruited from our outpatient department: group 1 in 2009 to 2014 and group 2 in 2012 to 2014. The inclusion criteria for group 1 were pain localized in the AC joint that ,"[70.0, 1188.0, 558.0, 1452.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,13,text,"the AC joint and a positive cross-body adduction test. The exclusion
criteria for both groups were rheumatoid arthritis, a history of shoul-
der surgery or fracture, glenohumeral osteoarthritis, ruptu","[594.0, 109.0, 1084.0, 198.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,14,text,All patients with shoulder pain were reviewed in our shoulder unit by 2 experienced shoulder surgeons using a standard protocol for clinical history and clinical examination. Data were collected in a ,"[595.0, 198.0, 1085.0, 375.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,15,paragraph_title,Signs on MRI,"[598.0, 404.0, 726.0, 431.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Signs on MRI""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,short_fragment,True,True
2,16,text,"All MRI scans were performed 2 to 3 weeks after the outpatient visit in our hospital on a 1.5-T Signa HDx TwinSpeed1 MRI system (General Electric, Milwaukee, WI, USA). The shoulder was placed in a ded","[596.0, 454.0, 1084.0, 653.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,17,text,"On the basis of previous research and clinical experience, 7 variables were evaluated on the MRI scans:","[595.0, 654.0, 1083.0, 697.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,18,text,"1. AC joint space narrowing: minimal space between the clavicle and acromion on axial images, with the cutoff value for joint space narrowing set at 2 mm","[615.0, 717.0, 1084.0, 783.0]",body_paragraph,0.6,"[""reference-like pattern: 1. AC joint space narrowing: minimal space between the clavi""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True
2,19,text,2. AC joint effusion: fluid-equivalent signal in the AC joint space,"[614.0, 784.0, 1084.0, 805.0]",body_paragraph,0.6,"[""reference-like pattern: 2. AC joint effusion: fluid-equivalent signal in the AC join""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True
2,20,text,3. Subchondral bone marrow edema of the distal clavicle and/or medial acromion: hyperintense signal from cranial to caudal on fat-saturated T2-weighted images and hypointense signal on T1-weighted ima,"[615.0, 800.0, 1083.0, 894.0]",body_paragraph,0.6,"[""reference-like pattern: 3. Subchondral bone marrow edema of the distal clavicle and/""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True
2,21,text,4. AC osteolysis: lytic bone lesion with cortical destruction of the distal clavicle,"[614.0, 894.0, 1084.0, 937.0]",body_paragraph,0.6,"[""reference-like pattern: 4. AC osteolysis: lytic bone lesion with cortical destructio""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True
2,22,text,"5. AC inferior osteophytes: inferior osteophyte, 2 mm or longer (length measured from a horizontal line on the original undersurface of the clavicle on coronal images, Fig. 1).","[614.0, 938.0, 1084.0, 1004.0]",body_paragraph,0.6,"[""reference-like pattern: 5. AC inferior osteophytes: inferior osteophyte, 2 mm or lon""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True
2,23,text,"6. Inferior AC joint distension: distal protrusion of the AC joint, 3 mm or longer (measured from a horizontal line on the original undersurface of the clavicle on sagittal or coronal images, Fig. 1).","[615.0, 1004.0, 1084.0, 1092.0]",body_paragraph,0.6,"[""reference-like pattern: 6. Inferior AC joint distension: distal protrusion of the AC""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True
2,24,text,"7. Impression on the supraspinatus due to the AC joint: 3 scores (on sagittal T1 or proton density sequences): (1) normal fat between AC joint and supraspinatus, (2) no fat between AC joint and supras","[615.0, 1092.0, 1084.0, 1203.0]",body_paragraph,0.6,"[""reference-like pattern: 7. Impression on the supraspinatus due to the AC joint: 3 sc""]",reference_item,0.6,,reference_like,reference_numeric_dot,True,True
2,25,text,"To enhance interpretation of the findings on MRI in clinical practice, variables were expressed dichotomously. Cutoff values for joint space narrowing, inferior osteophytes, and joint distension were ","[594.0, 1223.0, 1084.0, 1313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,26,paragraph_title,Statistical analysis Demographic and clinical characteristics,"[596.0, 1341.0, 948.0, 1405.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Statistical analysis Demographic and clinical characteristic""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
2,27,footer,,"[596.0, 1381.0, 948.0, 1405.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False
2,28,text,"The demographic and clinical characteristics were presented as proportion, mean (standard deviation), or median (interquartile range)","[595.0, 1407.0, 1084.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,0,header,ARTICLE IN PRESS,"[420.0, 11.0, 798.0, 50.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,1,header,Signs on MRI for AC osteoarthritis,"[104.0, 64.0, 386.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
3,2,number,3,"[1100.0, 67.0, 1113.0, 85.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,3,image,,"[118.0, 115.0, 575.0, 489.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,4,figure_title,"Figure 1 Measurement of inferior osteophyte (O) and inferior joint distension (JD) on coronal image from magnetic resonance imaging scan. A, acromion; Cl, clavicle; SS, supraspinatus; H, humerus.","[101.0, 505.0, 589.0, 573.0]",figure_caption,0.92,"[""figure_title label: Figure 1 Measurement of inferior osteophyte (O) and inferior""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
3,5,text,in the case of a skewed distribution. Differences between patients with symptomatic AC osteoarthritis and the control group were tested using independent-samples t tests for continuous variables or $,"[102.0, 599.0, 591.0, 689.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,6,paragraph_title,Analysis of MRI predictors for symptomatic AC osteoarthritis,"[101.0, 713.0, 505.0, 760.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Analysis of MRI predictors for symptomatic AC osteoarthritis""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
3,7,text,Univariate logistic regression analyses were performed to evaluate the association between each of the MRI findings individually and symptomatic AC osteoarthritis. MRI findings showing a significant a,"[101.0, 762.0, 591.0, 1202.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,8,paragraph_title,Intraobserver and interobserver variability,"[102.0, 1225.0, 510.0, 1250.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
3,9,text,"Intraobserver and interobserver variability was calculated for the findings of the final multivariate logistic regression model. This was done by calculating the k value, using data from 20 patients f","[101.0, 1274.0, 590.0, 1452.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,10,text,"variability was evaluated by comparing the values within the panel
of judges; intraobserver variability was evaluated by scoring the vari-
ables twice by the panel of judges on 2 days in different wee","[626.0, 110.0, 1116.0, 244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,11,paragraph_title,Results Demographic characteristics,"[628.0, 265.0, 901.0, 345.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Results Demographic characteristics""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
3,12,footer,,"[628.0, 318.0, 901.0, 345.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False
3,13,text,"Figure 3 shows a flow diagram of study enrollment. Between 2009 and 2014, 126 consecutive patients presented with clinical symptoms of AC osteoarthritis. To include only patients with isolated symptom","[625.0, 369.0, 1116.0, 850.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 3 shows a flow diagram of study enrollment. Between 2""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True
3,14,text,Complete demographic and clinical data for both groups are shown in Table I. Demographic parameters were comparable between the 2 groups. Significant differences were found between groups in the size ,"[626.0, 850.0, 1116.0, 1018.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,15,paragraph_title,MRI characteristics,"[628.0, 1040.0, 815.0, 1065.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: MRI characteristics""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
3,16,text,"Because bone marrow edema was found only in patients with symptomatic AC osteoarthritis and because osteolysis was not found in any patients, these variables were not included in the regression analys","[625.0, 1091.0, 1117.0, 1454.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,0,number,4,"[74.0, 66.0, 89.0, 86.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,1,header,ARTICLE IN PRESS,"[388.0, 11.0, 767.0, 51.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,2,header,E.J.D. Veen et al.,"[936.0, 64.0, 1081.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,3,image,,"[158.0, 115.0, 1001.0, 352.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,4,figure_title,"Figure 2 Compression of supraspinatus on sagittal images from magnetic resonance imaging scans: no contact (A), adjacent (B), and impression (C). A, acromion; Cl, clavicle; SS, supraspinatus; H, humer","[71.0, 369.0, 1085.0, 415.0]",figure_caption,0.92,"[""figure_title label: Figure 2 Compression of supraspinatus on sagittal images fro""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
4,5,image,,"[156.0, 444.0, 999.0, 898.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,6,figure_title,"Figure 3 Flowchart of study enrollment. AC, acromioclavicular.","[332.0, 923.0, 823.0, 946.0]",figure_caption,0.92,"[""figure_title label: Figure 3 Flowchart of study enrollment. AC, acromioclavicula""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
4,7,text,"confidence interval [CI], 3.53 to 36.44; P < .001 and joint distension (odds ratio, 3.38; 95% CI, 1.25 to 9.13; P = .016).","[70.0, 985.0, 556.0, 1033.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,8,text,"The Hosmer-Lemeshow test for goodness of fit of the model including these 2 variables was performed including only those patients without bone marrow edema and was not significant $ (P = .963) $, ind","[69.0, 1034.0, 558.0, 1251.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,9,paragraph_title,Intraobserver and interobserver variability,"[71.0, 1280.0, 478.0, 1306.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
4,10,text,"The mean κ value for intraobserver variability was 0.86 (95% CI, 0.75 to 1.00) for bone marrow edema, 0.68 (95% CI, 0.60 to 0.795) for AC joint distension, and 0.85 (95% CI, 0.75 to 0.94) for impressi","[69.0, 1331.0, 559.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,11,text,"edema, 0.70 (95% CI, 0.65 to 0.75) for AC joint distension,
and 0.84 (95% CI, 0.82 to 0.94) for impression. The mean
intraobserver variability and interobserver variability of im-
pression and bone ma","[594.0, 985.0, 1085.0, 1179.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,12,paragraph_title,Discussion,"[598.0, 1204.0, 713.0, 1231.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
4,13,text,The most important finding of our study was the correlation of 3 MRI signs with the clinical diagnosis of symptomatic AC osteoarthritis. The presence of bone marrow edema predicted a 100% probability ,"[594.0, 1259.0, 1086.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,0,header,ARTICLE IN PRESS,"[420.0, 10.0, 799.0, 50.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,1,header,Signs on MRI for AC osteoarthritis,"[105.0, 64.0, 387.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
5,2,number,5,"[1100.0, 66.0, 1114.0, 85.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,3,figure_title,Table I Demographic and clinical data and MRI findings of study population,"[115.0, 121.0, 699.0, 144.0]",figure_caption_candidate,0.85,"[""figure_title label: Table I Demographic and clinical data and MRI findings of st""]",figure_caption,0.85,,reference_like,citation_line,False,False
5,4,table,"<table><tr><td></td><td>Group 1 (n = 70)</td><td>Group 2 (n = 70)</td><td>P value</td></tr><tr><td>Male sex</td><td>32 (45.7%)</td><td>34 (48.6%)</td><td>.735</td></tr><tr><td>Mean age (SD), yr</td><t","[114.0, 147.0, 1101.0, 490.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True
5,5,vision_footnote,"MRI, magnetic resonance imaging; SD, standard deviation; AC, acromioclavicular.","[116.0, 496.0, 652.0, 517.0]",footnote,0.7,"[""vision_footnote label: MRI, magnetic resonance imaging; SD, standard deviation; AC,""]",footnote,0.7,body_zone,body_like,none,True,True
5,6,vision_footnote,"Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chronic subacromial pain syndrome.","[116.0, 516.0, 871.0, 538.0]",footnote,0.7,"[""vision_footnote label: Group 1 patients had symptomatic AC osteoarthritis, and grou""]",footnote,0.7,body_zone,body_like,none,True,True
5,7,vision_footnote,* Data are missing for 3 patients.,"[122.0, 537.0, 354.0, 556.0]",footnote,0.7,"[""vision_footnote label: * Data are missing for 3 patients.""]",footnote,0.7,body_zone,body_like,none,True,True
5,8,vision_footnote,Data are missing for 1 patient.,"[122.0, 557.0, 344.0, 577.0]",footnote,0.7,"[""vision_footnote label: Data are missing for 1 patient.""]",footnote,0.7,body_zone,body_like,none,True,True
5,9,figure_title,Table II Univariate association between potential predictor variables on MRI and symptomatic AC osteoarthritis,"[114.0, 635.0, 962.0, 657.0]",figure_caption_candidate,0.85,"[""figure_title label: Table II Univariate association between potential predictor ""]",figure_caption,0.85,body_zone,table_caption_like,none,False,False
5,10,table,<table><tr><td></td><td>Group 1 (n = 70)</td><td>Group 2 (n = 70)</td><td>Odds ratio (95% CI)</td><td>P value</td></tr><tr><td>Joint space ≤2 mm</td><td>57 (81%)</td><td>71 (87%)</td><td>0.647 (0.257-,"[113.0, 659.0, 1101.0, 850.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True
5,11,vision_footnote,"MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval.","[115.0, 855.0, 651.0, 876.0]",footnote,0.7,"[""vision_footnote label: MRI, magnetic resonance imaging; AC, acromioclavicular; CI, ""]",footnote,0.7,body_zone,body_like,none,True,True
5,12,vision_footnote,"Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chronic subacromial pain syndrome.","[115.0, 876.0, 871.0, 897.0]",footnote,0.7,"[""vision_footnote label: Group 1 patients had symptomatic AC osteoarthritis, and grou""]",footnote,0.7,body_zone,body_like,none,True,True
5,13,figure_title,Table III Multivariate logistic regression analysis of predictors on MRI for symptomatic AC osteoarthritis,"[114.0, 955.0, 908.0, 978.0]",figure_caption,0.85,"[""figure_title label: Table III Multivariate logistic regression analysis of predi""]",figure_caption,0.85,body_zone,table_caption_like,none,True,True
5,14,table,<table><tr><td>Variable</td><td>Coefficient</td><td>Odds ratio (95% CI)</td><td>P value</td></tr><tr><td>Inferior joint distension ≥3 mm</td><td>1.217</td><td>3.378 (1.249-9.133)</td><td>.016</td></tr,"[114.0, 970.0, 1104.0, 1061.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True
5,15,vision_footnote,"MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval.","[116.0, 1065.0, 650.0, 1087.0]",footnote,0.7,"[""vision_footnote label: MRI, magnetic resonance imaging; AC, acromioclavicular; CI, ""]",footnote,0.7,body_zone,body_like,none,True,True
5,16,text,"findings, with good to excellent $ \kappa $ values, are easy to use and can assist the physician in diagnosing symptomatic AC osteoarthritis and exclude other shoulder pathology.","[101.0, 1140.0, 589.0, 1211.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,17,text,Several clinical tests are available to diagnose symptomatic AC osteoarthritis. Painful palpation of the AC joint has a sensitivity of 96% and specificity of 10%. $ ^{22} $ Cross-body adduction has a ,"[101.0, 1213.0, 592.0, 1452.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,18,text,"varying accuracy.3,13,22 The current diagnostic process in shoul-
der pathology includes a clinical history, physical examination
with clinical tests, and additional radiographic examina-
tions. The p","[626.0, 1138.0, 1116.0, 1332.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,19,text,There are limited data available in the literature about the association between abnormal findings around the AC joint on an MRI scan and clinical tests of patients with symptoms of a degenerative AC ,"[626.0, 1331.0, 1117.0, 1453.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,0,number,6,"[75.0, 66.0, 89.0, 85.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,1,doc_title,ARTICLE IN PRESS,"[388.0, 10.0, 767.0, 51.0]",unknown_structural,0.2,"[""unrecognized label 'doc_title'""]",unknown_structural,0.2,body_zone,body_like,short_fragment,False,True
6,2,header,E.J.D. Veen et al.,"[937.0, 65.0, 1081.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,3,text,"symptomatic AC osteoarthritis and not in the control group. This was also found by Jordan et al $ ^{8} $ and Stein et al, $ ^{18} $ who noted a statistically significant correlation between high signa","[70.0, 110.0, 558.0, 205.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,4,text,"Another study showed the association of osteophytes and AC joint distension with symptomatic AC osteoarthritis, $ ^{2} $ and its findings were confirmed in our study. Strobel et al $ ^{20} $ retrospec","[70.0, 206.0, 558.0, 684.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,5,text,The comparative study of Choo et al $ ^{2} $ found bone edema in only 9% of symptomatic patients. This finding is in contrast to our study but may be the result of using another fat-saturated MRI prot,"[70.0, 685.0, 558.0, 949.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,6,text,One of the strengths of this study is the relatively large group of consecutive patients with isolated symptomatic AC osteoarthritis and the comparison with a control group of patients with subacromia,"[70.0, 949.0, 557.0, 1091.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,7,text,"This study also has some limitations. It has a retrospective design, creating a risk of selection bias. Our control group (group 2) consisted of patients with shoulder pain caused by subacromial pain ","[70.0, 1093.0, 559.0, 1452.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
6,8,text,"amination, and additional radio-diagnostic imaging studies.
Painful palpation of the AC joint and a positive cross-body
adduction test were used as clinical tests for inclusion. The
sensitivity and sp","[595.0, 110.0, 1085.0, 445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,9,text,"The prediction of symptomatic AC osteoarthritis using impression on the supraspinatus, joint distension, and bone marrow edema is based on point estimates of the coordinates for each of the variables,","[595.0, 447.0, 1085.0, 711.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,10,paragraph_title,Conclusion,"[611.0, 752.0, 727.0, 779.0]",structured_insert,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,False,False
6,11,text,"In this study we identified predictive MRI signs in patients with symptomatic AC osteoarthritis. A prediction model, including bone marrow edema, inferior joint distension, and impression on the supra","[607.0, 801.0, 1072.0, 972.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False
6,12,paragraph_title,Disclaimer,"[611.0, 1012.0, 726.0, 1040.0]",structured_insert,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Disclaimer""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,False,False
6,13,text,"The authors, their immediate families, and any research foundations with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the ","[607.0, 1063.0, 1072.0, 1161.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False
6,14,paragraph_title,References,"[599.0, 1214.0, 717.0, 1240.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True
6,15,reference_content,"1. Brown JN, Roberts SN, Hayes MG, Sales AD. Shoulder pathology associated with symptomatic acromioclavicular joint degeneration. J Shoulder Elbow Surg 2000;9:173-6.","[609.0, 1271.0, 1081.0, 1328.0]",reference_item,0.85,"[""reference content label: 1. Brown JN, Roberts SN, Hayes MG, Sales AD. Shoulder pathol""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,16,reference_content,"2. Choo HJ, Lee SJ, Kim JH, Cha SS, Park YM, Park JS, et al. Can symptomatic acromioclavicular joints be differentiated from asymptomatic acromioclavicular joints on 3-T MR imaging? Eur J Radiol 2013;","[607.0, 1331.0, 1083.0, 1409.0]",reference_item,0.85,"[""reference content label: 2. Choo HJ, Lee SJ, Kim JH, Cha SS, Park YM, Park JS, et al.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,17,reference_content,"3. Chronopoulos E, Kim TK, Park HB, Ashenbrenner D, McFarland EG. Diagnostic value of physical tests for isolated chronic acromioclavicular","[607.0, 1411.0, 1084.0, 1449.0]",reference_item,0.85,"[""reference content label: 3. Chronopoulos E, Kim TK, Park HB, Ashenbrenner D, McFarlan""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,0,header,Signs on MRI for AC osteoarthritis,"[106.0, 65.0, 385.0, 87.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
7,1,header,ARTICLE IN PRESS,"[420.0, 11.0, 798.0, 50.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False
7,2,number,7,"[1100.0, 68.0, 1113.0, 84.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
7,3,reference_content,lesions. Am J Sports Med 2004;32:655-61. http://dx.doi.org/10.1177/0363546503261723,"[131.0, 111.0, 588.0, 146.0]",reference_item,0.85,"[""reference content label: lesions. Am J Sports Med 2004;32:655-61. http://dx.doi.org/1""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
7,4,reference_content,"4. Colegate-Stone T, Allom R, Singh R, Elias DA, Standring S, Sinha J. Classification of the morphology of the acromioclavicular joint using cadaveric and radiological analysis. Bone Joint J 2010;92:7","[113.0, 151.0, 587.0, 227.0]",reference_item,0.85,"[""reference content label: 4. Colegate-Stone T, Allom R, Singh R, Elias DA, Standring S""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,5,reference_content,"5. Docimo S Jr, Kornitsky D, Futterman B, Elkowitz DE. Surgical treatment for acromioclavicular joint osteoarthritis: patient selection, surgical options, complications, and outcome. Curr Rev Musculos","[113.0, 231.0, 587.0, 307.0]",reference_item,0.85,"[""reference content label: 5. Docimo S Jr, Kornitsky D, Futterman B, Elkowitz DE. Surgi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,6,reference_content,"6. Heers G, Götz J, Schachner H, Neumaier U, Grifka J, Hedtmann A. Ultrasound evaluation of the acromioclavicular joint. A comparison with magnetic resonance imaging. Sportverletz Sportschaden 2005;19","[113.0, 311.0, 587.0, 388.0]",reference_item,0.85,"[""reference content label: 6. Heers G, G\u00f6tz J, Schachner H, Neumaier U, Grifka J, Hedtm""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,7,reference_content,"7. Hossain S, Jacobs LG, Hashmi R. The long-term effectiveness of steroid injections in primary acromioclavicular joint arthritis: a five-year prospective study. J Shoulder Elbow Surg 2008;17:535-8. h","[113.0, 391.0, 588.0, 467.0]",reference_item,0.85,"[""reference content label: 7. Hossain S, Jacobs LG, Hashmi R. The long-term effectivene""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,8,reference_content,"8. Jordan L, Kenter K, Griffiths H. Relationship between MRI and clinical findings in the acromioclavicular joint. Skeletal Radiol 2002;31:516-21. http://dx.doi.org/10.1007/s00256-002-0530-z","[113.0, 471.0, 587.0, 528.0]",reference_item,0.85,"[""reference content label: 8. Jordan L, Kenter K, Griffiths H. Relationship between MRI""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,9,reference_content,"9. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;159-74.","[112.0, 531.0, 588.0, 568.0]",reference_item,0.85,"[""reference content label: 9. Landis JR, Koch GG. The measurement of observer agreement""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,10,reference_content,"10. Mall NA, Foley E, Chalmers PN, Cole BJ, Romeo AA, Bach BR Jr. Degenerative joint disease of the acromioclavicular joint: a review. Am J Sports Med 2013;41:2684-92. http://dx.doi.org/10.1177/036354","[108.0, 570.0, 587.0, 646.0]",reference_item,0.85,"[""reference content label: 10. Mall NA, Foley E, Chalmers PN, Cole BJ, Romeo AA, Bach B""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,11,reference_content,"11. McFarland EG, Garzon-Muvdi J, Jia X, Desai P, Petersen SA. Clinical and diagnostic tests for shoulder disorders: a critical review. Br J Sports Med 2010;44:328-32. http://dx.doi.org/10.1136/bjsm.2","[108.0, 650.0, 586.0, 725.0]",reference_item,0.85,"[""reference content label: 11. McFarland EG, Garzon-Muvdi J, Jia X, Desai P, Petersen S""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,12,reference_content,"12. Menge TJ, Boykin RE, Bushnell BD, Byram IR. Acromioclavicular osteoarthritis: a common cause of shoulder pain. South Med J 2014;107:324-9. http://dx.doi.org/10.1097/SMJ.0000000000000101","[107.0, 730.0, 588.0, 787.0]",reference_item,0.85,"[""reference content label: 12. Menge TJ, Boykin RE, Bushnell BD, Byram IR. Acromioclavi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,13,reference_content,"13. O'Brien SJ, Pagnani MJ, Fealy S, McGlynn SR, Wilson JB. The active compression test: a new and effective test for diagnosing labral tears and acromioclavicular joint abnormality. Am J Sports Med 1","[634.0, 111.0, 1113.0, 186.0]",reference_item,0.85,"[""reference content label: 13. O'Brien SJ, Pagnani MJ, Fealy S, McGlynn SR, Wilson JB. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,14,reference_content,"14. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996;49:1373-9.","[634.0, 191.0, 1112.0, 248.0]",reference_item,0.85,"[""reference content label: 14. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,15,reference_content,"15. Pensak M, Grumet RC, Slabaugh MA, Bach BR. Open versus arthroscopic distal clavicle resection. Arthroscopy 2010;26:697-704. http://dx.doi.org/10.1016/j.arthro.2009.12.007","[634.0, 251.0, 1112.0, 307.0]",reference_item,0.85,"[""reference content label: 15. Pensak M, Grumet RC, Slabaugh MA, Bach BR. Open versus a""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,16,reference_content,"16. Raynor MB, Kuhn JE. Utility of features of the patient's history in the diagnosis of atraumatic shoulder pain: a systematic review. J Shoulder Elbow Surg 2016;25:688-94. http://dx.doi.org/10.1016/","[633.0, 311.0, 1114.0, 368.0]",reference_item,0.85,"[""reference content label: 16. Raynor MB, Kuhn JE. Utility of features of the patient's""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,17,reference_content,"17. Schünke M, Schulte E, Schumacher U, Voll M, Wesker K. Anatomische atlas Prometheurs: algemene anatomie en bewegingsapparaat. Stuttgart, Germany: Thieme; 2005.","[634.0, 371.0, 1113.0, 428.0]",reference_item,0.85,"[""reference content label: 17. Sch\u00fcnke M, Schulte E, Schumacher U, Voll M, Wesker K. An""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,18,reference_content,"18. Shubin Stein BE, Ahmad CS, Pfaff CH, Bigliani LU, Levine WN. A comparison of magnetic resonance imaging findings of the acromioclavicular joint in symptomatic versus asymptomatic patients. J Shoul","[635.0, 431.0, 1114.0, 527.0]",reference_item,0.85,"[""reference content label: 18. Shubin Stein BE, Ahmad CS, Pfaff CH, Bigliani LU, Levine""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,19,reference_content,"19. Shubin Stein BE, Wiater JM, Pfaff HC, Bigliani LU, Levine WN. Detection of acromioclavicular joint pathology in asymptomatic shoulders with magnetic resonance imaging. J Shoulder Elbow Surg 2001;1","[633.0, 530.0, 1113.0, 588.0]",reference_item,0.85,"[""reference content label: 19. Shubin Stein BE, Wiater JM, Pfaff HC, Bigliani LU, Levin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,20,reference_content,"20. Strobel K, Pfirrmann CW, Zanetti M, Nagy L, Hodler J. MRI features of the acromioclavicular joint that predict pain relief from intraarticular injection. AJR Am J Roentgenol 2003;181:755-60. http:","[632.0, 590.0, 1113.0, 666.0]",reference_item,0.85,"[""reference content label: 20. Strobel K, Pfirrmann CW, Zanetti M, Nagy L, Hodler J. MR""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,21,reference_content,"21. van Riet RP, Goehre T, Bell SN. The long term effect of an intra-articular injection of corticosteroids in the acromioclavicular joint. J Shoulder Elbow Surg 2012;21:376-9. http://dx.doi.org/10.10","[631.0, 669.0, 1114.0, 727.0]",reference_item,0.85,"[""reference content label: 21. van Riet RP, Goehre T, Bell SN. The long term effect of ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,22,reference_content,"22. Walton J, Mahajan S, Paxinos A, Marshall J, Bryant C, Shnier R, et al. Diagnostic values of tests for acromioclavicular joint pain. J Bone Joint Surg Am 2004;86:807-12.","[631.0, 730.0, 1114.0, 786.0]",reference_item,0.85,"[""reference content label: 22. Walton J, Mahajan S, Paxinos A, Marshall J, Bryant C, Sh""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 header J Shoulder Elbow Surg (2018) [104.0, 64.0, 305.0, 84.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
3 1 1 header_image [106.0, 103.0, 216.0, 199.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False True
4 1 2 header ARTICLE IN PRESS [419.0, 9.0, 799.0, 51.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like short_fragment False False
5 1 3 header JOURNAL OF SHOULDER AND ELBOW SURGERY [949.0, 79.0, 1110.0, 175.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
6 1 4 header www.elsevier.com/locate/ymse [911.0, 191.0, 1115.0, 211.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
7 1 5 text ORIGINAL ARTICLE [103.0, 248.0, 301.0, 276.0] authors 0.6 ["page-1 initial-lastname author byline: ORIGINAL ARTICLE"] authors 0.6 frontmatter_main_zone support_like short_fragment True True
8 1 6 doc_title Predictive findings on magnetic resonance imaging in patients with symptomatic acromioclavicular osteoarthritis [101.0, 309.0, 826.0, 447.0] paper_title 0.8 ["page-1 zone title_zone: Predictive findings on magnetic resonance imaging in patient"] paper_title 0.8 frontmatter_main_zone support_like none True True
9 1 7 text Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $ ^{a} $, Robin E. Westerbeek, MD $ ^{c} $, Rosalie P.H. Derks, MD $ ^{c} $, Ellie B.M. Landman, PhD $ ^{a} $, Cornelis T. Koorevaar, MD, PhD [102.0, 475.0, 1076.0, 542.0] authors 0.8 ["page-1 zone author_zone: Egbert J.D. Veen, MD $ ^{a,b,*} $, Cornelia M. Donders, MD $"] authors 0.8 frontmatter_main_zone support_like none True True
10 1 8 text $ ^{a} $Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, Deventer, The Netherlands $ ^{b} $Department of Orthopaedic Surgery, University Medical Center, University of Groningen [101.0, 570.0, 1069.0, 646.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{a} $Department of Orthopaedic Surgery and Traumatology, "] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
11 1 9 abstract Background: A magnetic resonance imaging (MRI) scan of the shoulder can have added value in diagnosing symptomatic osteoarthritis of the acromioclavicular (AC) joint. Specific MRI signs have been reco [113.0, 684.0, 880.0, 774.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
12 1 10 abstract Methods: The MRI scans of 70 patients with symptomatic AC osteoarthritis were compared with those of 70 patients with subacromial pain syndrome and no clinical signs of symptomatic AC osteoarthritis. [114.0, 774.0, 881.0, 887.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
13 1 11 abstract Results: The presence of inferior osteophytes, bone marrow edema, impression on the supraspinatus, and inferior joint distension was individually associated with symptomatic AC osteoarthritis. Bone ma [114.0, 885.0, 880.0, 1038.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
14 1 12 abstract Conclusion: We identified predictive MRI signs in patients with symptomatic AC osteoarthritis. These findings, including bone marrow edema, inferior joint distension, and impression on the supraspinat [114.0, 1038.0, 879.0, 1126.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
15 1 13 text Level of evidence: Level IV; Case-Control Design; Diagnostic Study © 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved. [115.0, 1125.0, 731.0, 1171.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Level of evidence: Level IV; Case-Control Design; Diagnostic"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
16 1 14 text Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow edema; impression on musculus supraspinatus; predictive findings [114.0, 1176.0, 879.0, 1221.0] frontmatter_noise 0.7 ["frontmatter noise text: Keywords: AC joint; AC osteoarthritis; MRI scan; bone marrow"] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
17 1 15 footnote Approval of this study was obtained from the regional Medical Ethical Committee (METC Isala, No. 15.0222). [101.0, 1303.0, 833.0, 1324.0] footnote 0.7 ["footnote label: Approval of this study was obtained from the regional Medica"] footnote 0.7 frontmatter_main_zone support_like none True True
18 1 16 footnote $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department of Orthopaedic Surgery and Traumatology, Deventer Hospital, PO Box 5001, NL-7400 GC Deventer, The Netherlands. [102.0, 1321.0, 1116.0, 1366.0] footnote 0.7 ["footnote label: $ ^{*} $Reprint requests: Egbert J.D. Veen, MD, Department o"] footnote 0.7 frontmatter_main_zone support_like affiliation_marker True True
19 1 17 footnote E-mail address: ejdveen@gmail.com (E.J.D. Veen). [126.0, 1365.0, 464.0, 1385.0] footnote 0.7 ["footnote label: E-mail address: ejdveen@gmail.com (E.J.D. Veen)."] footnote 0.7 frontmatter_main_zone support_like none True True
20 1 18 footer 1058-2746/$ - see front matter © 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved. https://doi.org/10.1016/j.jse.2018.01.001 [102.0, 1407.0, 875.0, 1449.0] noise 0.9 ["footer label"] noise 0.9 frontmatter_main_zone support_like none False False
21 2 0 number 2 [75.0, 65.0, 88.0, 85.0] noise 0.9 ["page number label"] noise 0.9 frontmatter_side_zone support_like short_fragment False False
22 2 1 doc_title ARTICLE IN PRESS [388.0, 10.0, 767.0, 51.0] unknown_structural 0.2 ["unrecognized label 'doc_title'"] unknown_structural 0.2 frontmatter_side_zone support_like short_fragment False True
23 2 2 header E.J.D. Veen et al. [937.0, 65.0, 1081.0, 87.0] noise 0.9 ["header label"] noise 0.9 frontmatter_side_zone support_like short_fragment False False
24 2 3 text Degeneration of the acromioclavicular (AC) joint, with joint space narrowing and osteophyte formation, is part of the normal aging process. $ ^{[10,19]} $ In most of the general population, osteoarthr [70.0, 109.0, 558.0, 373.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
25 2 4 text The diagnosis of symptomatic AC osteoarthritis is made by an accurate history, clinical examination, and additional radiodiagnostic imaging studies. Previous studies have debated the accuracy and reli [70.0, 374.0, 557.0, 541.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
26 2 5 text Previous research has shown that advanced signs of degeneration in the AC joint seen on the MRI scan are correlated with symptoms and that bone marrow edema is only observed in patients with symptomat [70.0, 542.0, 558.0, 685.0] unknown_structural 0.8 ["page-1 zone author_zone: Previous research has shown that advanced signs of degenerat"] authors 0.8 body_zone body_like none False True
27 2 6 text The aim of this study was to identify predictive MRI signs in patients with symptomatic AC osteoarthritis. We hypothesized that specific MRI signs would be found in patients with symptomatic AC osteoa [70.0, 685.0, 558.0, 783.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
28 2 7 paragraph_title Materials and methods Design [72.0, 808.0, 310.0, 887.0] unknown_structural 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Materials and methods Design"] subsection_heading 0.6 frontmatter_side_zone heading_like none False True
29 2 8 footer [72.0, 860.0, 142.0, 887.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like empty False False
30 2 9 text This study had a retrospective, case-control, diagnostic study design and was conducted in a general teaching hospital with a specialized shoulder unit. [70.0, 911.0, 557.0, 978.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
31 2 10 paragraph_title Study population [71.0, 1005.0, 238.0, 1031.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Study population"] subsection_heading 0.6 body_zone heading_like short_fragment True True
32 2 11 text A total of 140 patients were selected from the electronic patient files: 70 consecutive patients with clinical isolated symptomatic AC osteoarthritis (group 1) and 70 consecutive patients with chronic [70.0, 1054.0, 558.0, 1187.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
33 2 12 text Patients in both groups were recruited from our outpatient department: group 1 in 2009 to 2014 and group 2 in 2012 to 2014. The inclusion criteria for group 1 were pain localized in the AC joint that [70.0, 1188.0, 558.0, 1452.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
34 2 13 text the AC joint and a positive cross-body adduction test. The exclusion criteria for both groups were rheumatoid arthritis, a history of shoul- der surgery or fracture, glenohumeral osteoarthritis, ruptu [594.0, 109.0, 1084.0, 198.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
35 2 14 text All patients with shoulder pain were reviewed in our shoulder unit by 2 experienced shoulder surgeons using a standard protocol for clinical history and clinical examination. Data were collected in a [595.0, 198.0, 1085.0, 375.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
36 2 15 paragraph_title Signs on MRI [598.0, 404.0, 726.0, 431.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Signs on MRI"] subsection_heading 0.6 frontmatter_side_zone heading_like short_fragment True True
37 2 16 text All MRI scans were performed 2 to 3 weeks after the outpatient visit in our hospital on a 1.5-T Signa HDx TwinSpeed1 MRI system (General Electric, Milwaukee, WI, USA). The shoulder was placed in a ded [596.0, 454.0, 1084.0, 653.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
38 2 17 text On the basis of previous research and clinical experience, 7 variables were evaluated on the MRI scans: [595.0, 654.0, 1083.0, 697.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
39 2 18 text 1. AC joint space narrowing: minimal space between the clavicle and acromion on axial images, with the cutoff value for joint space narrowing set at 2 mm [615.0, 717.0, 1084.0, 783.0] body_paragraph 0.6 ["reference-like pattern: 1. AC joint space narrowing: minimal space between the clavi"] reference_item 0.6 reference_like reference_numeric_dot True True
40 2 19 text 2. AC joint effusion: fluid-equivalent signal in the AC joint space [614.0, 784.0, 1084.0, 805.0] body_paragraph 0.6 ["reference-like pattern: 2. AC joint effusion: fluid-equivalent signal in the AC join"] reference_item 0.6 reference_like reference_numeric_dot True True
41 2 20 text 3. Subchondral bone marrow edema of the distal clavicle and/or medial acromion: hyperintense signal from cranial to caudal on fat-saturated T2-weighted images and hypointense signal on T1-weighted ima [615.0, 800.0, 1083.0, 894.0] body_paragraph 0.6 ["reference-like pattern: 3. Subchondral bone marrow edema of the distal clavicle and/"] reference_item 0.6 reference_like reference_numeric_dot True True
42 2 21 text 4. AC osteolysis: lytic bone lesion with cortical destruction of the distal clavicle [614.0, 894.0, 1084.0, 937.0] body_paragraph 0.6 ["reference-like pattern: 4. AC osteolysis: lytic bone lesion with cortical destructio"] reference_item 0.6 reference_like reference_numeric_dot True True
43 2 22 text 5. AC inferior osteophytes: inferior osteophyte, 2 mm or longer (length measured from a horizontal line on the original undersurface of the clavicle on coronal images, Fig. 1). [614.0, 938.0, 1084.0, 1004.0] body_paragraph 0.6 ["reference-like pattern: 5. AC inferior osteophytes: inferior osteophyte, 2 mm or lon"] reference_item 0.6 reference_like reference_numeric_dot True True
44 2 23 text 6. Inferior AC joint distension: distal protrusion of the AC joint, 3 mm or longer (measured from a horizontal line on the original undersurface of the clavicle on sagittal or coronal images, Fig. 1). [615.0, 1004.0, 1084.0, 1092.0] body_paragraph 0.6 ["reference-like pattern: 6. Inferior AC joint distension: distal protrusion of the AC"] reference_item 0.6 reference_like reference_numeric_dot True True
45 2 24 text 7. Impression on the supraspinatus due to the AC joint: 3 scores (on sagittal T1 or proton density sequences): (1) normal fat between AC joint and supraspinatus, (2) no fat between AC joint and supras [615.0, 1092.0, 1084.0, 1203.0] body_paragraph 0.6 ["reference-like pattern: 7. Impression on the supraspinatus due to the AC joint: 3 sc"] reference_item 0.6 reference_like reference_numeric_dot True True
46 2 25 text To enhance interpretation of the findings on MRI in clinical practice, variables were expressed dichotomously. Cutoff values for joint space narrowing, inferior osteophytes, and joint distension were [594.0, 1223.0, 1084.0, 1313.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
47 2 26 paragraph_title Statistical analysis Demographic and clinical characteristics [596.0, 1341.0, 948.0, 1405.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Statistical analysis Demographic and clinical characteristic"] subsection_heading 0.6 body_zone heading_like none True True
48 2 27 footer [596.0, 1381.0, 948.0, 1405.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like empty False False
49 2 28 text The demographic and clinical characteristics were presented as proportion, mean (standard deviation), or median (interquartile range) [595.0, 1407.0, 1084.0, 1453.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
50 3 0 header ARTICLE IN PRESS [420.0, 11.0, 798.0, 50.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
51 3 1 header Signs on MRI for AC osteoarthritis [104.0, 64.0, 386.0, 88.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
52 3 2 number 3 [1100.0, 67.0, 1113.0, 85.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
53 3 3 image [118.0, 115.0, 575.0, 489.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
54 3 4 figure_title Figure 1 Measurement of inferior osteophyte (O) and inferior joint distension (JD) on coronal image from magnetic resonance imaging scan. A, acromion; Cl, clavicle; SS, supraspinatus; H, humerus. [101.0, 505.0, 589.0, 573.0] figure_caption 0.92 ["figure_title label: Figure 1 Measurement of inferior osteophyte (O) and inferior"] figure_caption 0.92 display_zone legend_like figure_number True True
55 3 5 text in the case of a skewed distribution. Differences between patients with symptomatic AC osteoarthritis and the control group were tested using independent-samples t tests for continuous variables or $ [102.0, 599.0, 591.0, 689.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
56 3 6 paragraph_title Analysis of MRI predictors for symptomatic AC osteoarthritis [101.0, 713.0, 505.0, 760.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Analysis of MRI predictors for symptomatic AC osteoarthritis"] subsection_heading 0.6 body_zone heading_like none True True
57 3 7 text Univariate logistic regression analyses were performed to evaluate the association between each of the MRI findings individually and symptomatic AC osteoarthritis. MRI findings showing a significant a [101.0, 762.0, 591.0, 1202.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
58 3 8 paragraph_title Intraobserver and interobserver variability [102.0, 1225.0, 510.0, 1250.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability"] subsection_heading 0.6 body_zone heading_like none True True
59 3 9 text Intraobserver and interobserver variability was calculated for the findings of the final multivariate logistic regression model. This was done by calculating the k value, using data from 20 patients f [101.0, 1274.0, 590.0, 1452.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
60 3 10 text variability was evaluated by comparing the values within the panel of judges; intraobserver variability was evaluated by scoring the vari- ables twice by the panel of judges on 2 days in different wee [626.0, 110.0, 1116.0, 244.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
61 3 11 paragraph_title Results Demographic characteristics [628.0, 265.0, 901.0, 345.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Results Demographic characteristics"] subsection_heading 0.6 body_zone heading_like none True True
62 3 12 footer [628.0, 318.0, 901.0, 345.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like empty False False
63 3 13 text Figure 3 shows a flow diagram of study enrollment. Between 2009 and 2014, 126 consecutive patients presented with clinical symptoms of AC osteoarthritis. To include only patients with isolated symptom [625.0, 369.0, 1116.0, 850.0] body_paragraph 0.9 ["figure caption candidate (body narrative): Figure 3 shows a flow diagram of study enrollment. Between 2"] figure_caption_candidate 0.9 display_zone legend_like figure_number True True
64 3 14 text Complete demographic and clinical data for both groups are shown in Table I. Demographic parameters were comparable between the 2 groups. Significant differences were found between groups in the size [626.0, 850.0, 1116.0, 1018.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
65 3 15 paragraph_title MRI characteristics [628.0, 1040.0, 815.0, 1065.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: MRI characteristics"] subsection_heading 0.6 body_zone heading_like short_fragment True True
66 3 16 text Because bone marrow edema was found only in patients with symptomatic AC osteoarthritis and because osteolysis was not found in any patients, these variables were not included in the regression analys [625.0, 1091.0, 1117.0, 1454.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
67 4 0 number 4 [74.0, 66.0, 89.0, 86.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
68 4 1 header ARTICLE IN PRESS [388.0, 11.0, 767.0, 51.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
69 4 2 header E.J.D. Veen et al. [936.0, 64.0, 1081.0, 87.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
70 4 3 image [158.0, 115.0, 1001.0, 352.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
71 4 4 figure_title Figure 2 Compression of supraspinatus on sagittal images from magnetic resonance imaging scans: no contact (A), adjacent (B), and impression (C). A, acromion; Cl, clavicle; SS, supraspinatus; H, humer [71.0, 369.0, 1085.0, 415.0] figure_caption 0.92 ["figure_title label: Figure 2 Compression of supraspinatus on sagittal images fro"] figure_caption 0.92 display_zone legend_like figure_number True True
72 4 5 image [156.0, 444.0, 999.0, 898.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
73 4 6 figure_title Figure 3 Flowchart of study enrollment. AC, acromioclavicular. [332.0, 923.0, 823.0, 946.0] figure_caption 0.92 ["figure_title label: Figure 3 Flowchart of study enrollment. AC, acromioclavicula"] figure_caption 0.92 display_zone legend_like figure_number True True
74 4 7 text confidence interval [CI], 3.53 to 36.44; P < .001 and joint distension (odds ratio, 3.38; 95% CI, 1.25 to 9.13; P = .016). [70.0, 985.0, 556.0, 1033.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
75 4 8 text The Hosmer-Lemeshow test for goodness of fit of the model including these 2 variables was performed including only those patients without bone marrow edema and was not significant $ (P = .963) $, ind [69.0, 1034.0, 558.0, 1251.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
76 4 9 paragraph_title Intraobserver and interobserver variability [71.0, 1280.0, 478.0, 1306.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Intraobserver and interobserver variability"] subsection_heading 0.6 body_zone heading_like none True True
77 4 10 text The mean κ value for intraobserver variability was 0.86 (95% CI, 0.75 to 1.00) for bone marrow edema, 0.68 (95% CI, 0.60 to 0.795) for AC joint distension, and 0.85 (95% CI, 0.75 to 0.94) for impressi [69.0, 1331.0, 559.0, 1453.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
78 4 11 text edema, 0.70 (95% CI, 0.65 to 0.75) for AC joint distension, and 0.84 (95% CI, 0.82 to 0.94) for impression. The mean intraobserver variability and interobserver variability of im- pression and bone ma [594.0, 985.0, 1085.0, 1179.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
79 4 12 paragraph_title Discussion [598.0, 1204.0, 713.0, 1231.0] section_heading 0.9 ["explicit scholarly heading: Discussion"] section_heading 0.9 body_zone heading_like canonical_section_name True True
80 4 13 text The most important finding of our study was the correlation of 3 MRI signs with the clinical diagnosis of symptomatic AC osteoarthritis. The presence of bone marrow edema predicted a 100% probability [594.0, 1259.0, 1086.0, 1453.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
81 5 0 header ARTICLE IN PRESS [420.0, 10.0, 799.0, 50.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
82 5 1 header Signs on MRI for AC osteoarthritis [105.0, 64.0, 387.0, 88.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
83 5 2 number 5 [1100.0, 66.0, 1114.0, 85.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
84 5 3 figure_title Table I Demographic and clinical data and MRI findings of study population [115.0, 121.0, 699.0, 144.0] figure_caption_candidate 0.85 ["figure_title label: Table I Demographic and clinical data and MRI findings of st"] figure_caption 0.85 reference_like citation_line False False
85 5 4 table <table><tr><td></td><td>Group 1 (n = 70)</td><td>Group 2 (n = 70)</td><td>P value</td></tr><tr><td>Male sex</td><td>32 (45.7%)</td><td>34 (48.6%)</td><td>.735</td></tr><tr><td>Mean age (SD), yr</td><t [114.0, 147.0, 1101.0, 490.0] media_asset 0.85 ["media label: table"] media_asset 0.85 body_zone body_like none True True
86 5 5 vision_footnote MRI, magnetic resonance imaging; SD, standard deviation; AC, acromioclavicular. [116.0, 496.0, 652.0, 517.0] footnote 0.7 ["vision_footnote label: MRI, magnetic resonance imaging; SD, standard deviation; AC,"] footnote 0.7 body_zone body_like none True True
87 5 6 vision_footnote Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chronic subacromial pain syndrome. [116.0, 516.0, 871.0, 538.0] footnote 0.7 ["vision_footnote label: Group 1 patients had symptomatic AC osteoarthritis, and grou"] footnote 0.7 body_zone body_like none True True
88 5 7 vision_footnote * Data are missing for 3 patients. [122.0, 537.0, 354.0, 556.0] footnote 0.7 ["vision_footnote label: * Data are missing for 3 patients."] footnote 0.7 body_zone body_like none True True
89 5 8 vision_footnote Data are missing for 1 patient. [122.0, 557.0, 344.0, 577.0] footnote 0.7 ["vision_footnote label: Data are missing for 1 patient."] footnote 0.7 body_zone body_like none True True
90 5 9 figure_title Table II Univariate association between potential predictor variables on MRI and symptomatic AC osteoarthritis [114.0, 635.0, 962.0, 657.0] figure_caption_candidate 0.85 ["figure_title label: Table II Univariate association between potential predictor "] figure_caption 0.85 body_zone table_caption_like none False False
91 5 10 table <table><tr><td></td><td>Group 1 (n = 70)</td><td>Group 2 (n = 70)</td><td>Odds ratio (95% CI)</td><td>P value</td></tr><tr><td>Joint space ≤2 mm</td><td>57 (81%)</td><td>71 (87%)</td><td>0.647 (0.257- [113.0, 659.0, 1101.0, 850.0] media_asset 0.85 ["media label: table"] media_asset 0.85 body_zone body_like none True True
92 5 11 vision_footnote MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval. [115.0, 855.0, 651.0, 876.0] footnote 0.7 ["vision_footnote label: MRI, magnetic resonance imaging; AC, acromioclavicular; CI, "] footnote 0.7 body_zone body_like none True True
93 5 12 vision_footnote Group 1 patients had symptomatic AC osteoarthritis, and group 2 patients had chronic subacromial pain syndrome. [115.0, 876.0, 871.0, 897.0] footnote 0.7 ["vision_footnote label: Group 1 patients had symptomatic AC osteoarthritis, and grou"] footnote 0.7 body_zone body_like none True True
94 5 13 figure_title Table III Multivariate logistic regression analysis of predictors on MRI for symptomatic AC osteoarthritis [114.0, 955.0, 908.0, 978.0] figure_caption 0.85 ["figure_title label: Table III Multivariate logistic regression analysis of predi"] figure_caption 0.85 body_zone table_caption_like none True True
95 5 14 table <table><tr><td>Variable</td><td>Coefficient</td><td>Odds ratio (95% CI)</td><td>P value</td></tr><tr><td>Inferior joint distension ≥3 mm</td><td>1.217</td><td>3.378 (1.249-9.133)</td><td>.016</td></tr [114.0, 970.0, 1104.0, 1061.0] media_asset 0.85 ["media label: table"] media_asset 0.85 body_zone body_like none True True
96 5 15 vision_footnote MRI, magnetic resonance imaging; AC, acromioclavicular; CI, confidence interval. [116.0, 1065.0, 650.0, 1087.0] footnote 0.7 ["vision_footnote label: MRI, magnetic resonance imaging; AC, acromioclavicular; CI, "] footnote 0.7 body_zone body_like none True True
97 5 16 text findings, with good to excellent $ \kappa $ values, are easy to use and can assist the physician in diagnosing symptomatic AC osteoarthritis and exclude other shoulder pathology. [101.0, 1140.0, 589.0, 1211.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
98 5 17 text Several clinical tests are available to diagnose symptomatic AC osteoarthritis. Painful palpation of the AC joint has a sensitivity of 96% and specificity of 10%. $ ^{22} $ Cross-body adduction has a [101.0, 1213.0, 592.0, 1452.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
99 5 18 text varying accuracy.3,13,22 The current diagnostic process in shoul- der pathology includes a clinical history, physical examination with clinical tests, and additional radiographic examina- tions. The p [626.0, 1138.0, 1116.0, 1332.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
100 5 19 text There are limited data available in the literature about the association between abnormal findings around the AC joint on an MRI scan and clinical tests of patients with symptoms of a degenerative AC [626.0, 1331.0, 1117.0, 1453.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
101 6 0 number 6 [75.0, 66.0, 89.0, 85.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
102 6 1 doc_title ARTICLE IN PRESS [388.0, 10.0, 767.0, 51.0] unknown_structural 0.2 ["unrecognized label 'doc_title'"] unknown_structural 0.2 body_zone body_like short_fragment False True
103 6 2 header E.J.D. Veen et al. [937.0, 65.0, 1081.0, 87.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
104 6 3 text symptomatic AC osteoarthritis and not in the control group. This was also found by Jordan et al $ ^{8} $ and Stein et al, $ ^{18} $ who noted a statistically significant correlation between high signa [70.0, 110.0, 558.0, 205.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
105 6 4 text Another study showed the association of osteophytes and AC joint distension with symptomatic AC osteoarthritis, $ ^{2} $ and its findings were confirmed in our study. Strobel et al $ ^{20} $ retrospec [70.0, 206.0, 558.0, 684.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
106 6 5 text The comparative study of Choo et al $ ^{2} $ found bone edema in only 9% of symptomatic patients. This finding is in contrast to our study but may be the result of using another fat-saturated MRI prot [70.0, 685.0, 558.0, 949.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
107 6 6 text One of the strengths of this study is the relatively large group of consecutive patients with isolated symptomatic AC osteoarthritis and the comparison with a control group of patients with subacromia [70.0, 949.0, 557.0, 1091.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
108 6 7 text This study also has some limitations. It has a retrospective design, creating a risk of selection bias. Our control group (group 2) consisted of patients with shoulder pain caused by subacromial pain [70.0, 1093.0, 559.0, 1452.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
109 6 8 text amination, and additional radio-diagnostic imaging studies. Painful palpation of the AC joint and a positive cross-body adduction test were used as clinical tests for inclusion. The sensitivity and sp [595.0, 110.0, 1085.0, 445.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
110 6 9 text The prediction of symptomatic AC osteoarthritis using impression on the supraspinatus, joint distension, and bone marrow edema is based on point estimates of the coordinates for each of the variables, [595.0, 447.0, 1085.0, 711.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
111 6 10 paragraph_title Conclusion [611.0, 752.0, 727.0, 779.0] structured_insert 0.9 ["explicit scholarly heading: Conclusion"] section_heading 0.9 body_zone heading_like canonical_section_name False False
112 6 11 text In this study we identified predictive MRI signs in patients with symptomatic AC osteoarthritis. A prediction model, including bone marrow edema, inferior joint distension, and impression on the supra [607.0, 801.0, 1072.0, 972.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none False False
113 6 12 paragraph_title Disclaimer [611.0, 1012.0, 726.0, 1040.0] structured_insert 0.6 ["unnumbered paragraph_title, inferred level sub_subsection_heading: Disclaimer"] sub_subsection_heading 0.6 body_zone heading_like short_fragment False False
114 6 13 text The authors, their immediate families, and any research foundations with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the [607.0, 1063.0, 1072.0, 1161.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none False False
115 6 14 paragraph_title References [599.0, 1214.0, 717.0, 1240.0] reference_heading 0.9 ["references heading: References"] reference_heading 0.9 reference_zone heading_like short_fragment True True
116 6 15 reference_content 1. Brown JN, Roberts SN, Hayes MG, Sales AD. Shoulder pathology associated with symptomatic acromioclavicular joint degeneration. J Shoulder Elbow Surg 2000;9:173-6. [609.0, 1271.0, 1081.0, 1328.0] reference_item 0.85 ["reference content label: 1. Brown JN, Roberts SN, Hayes MG, Sales AD. Shoulder pathol"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
117 6 16 reference_content 2. Choo HJ, Lee SJ, Kim JH, Cha SS, Park YM, Park JS, et al. Can symptomatic acromioclavicular joints be differentiated from asymptomatic acromioclavicular joints on 3-T MR imaging? Eur J Radiol 2013; [607.0, 1331.0, 1083.0, 1409.0] reference_item 0.85 ["reference content label: 2. Choo HJ, Lee SJ, Kim JH, Cha SS, Park YM, Park JS, et al."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
118 6 17 reference_content 3. Chronopoulos E, Kim TK, Park HB, Ashenbrenner D, McFarland EG. Diagnostic value of physical tests for isolated chronic acromioclavicular [607.0, 1411.0, 1084.0, 1449.0] reference_item 0.85 ["reference content label: 3. Chronopoulos E, Kim TK, Park HB, Ashenbrenner D, McFarlan"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
119 7 0 header Signs on MRI for AC osteoarthritis [106.0, 65.0, 385.0, 87.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
120 7 1 header ARTICLE IN PRESS [420.0, 11.0, 798.0, 50.0] noise 0.9 ["header label"] noise 0.9 unknown_like short_fragment False False
121 7 2 number 7 [1100.0, 68.0, 1113.0, 84.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
122 7 3 reference_content lesions. Am J Sports Med 2004;32:655-61. http://dx.doi.org/10.1177/0363546503261723 [131.0, 111.0, 588.0, 146.0] reference_item 0.85 ["reference content label: lesions. Am J Sports Med 2004;32:655-61. http://dx.doi.org/1"] reference_item 0.85 reference_zone unknown_like none True True
123 7 4 reference_content 4. Colegate-Stone T, Allom R, Singh R, Elias DA, Standring S, Sinha J. Classification of the morphology of the acromioclavicular joint using cadaveric and radiological analysis. Bone Joint J 2010;92:7 [113.0, 151.0, 587.0, 227.0] reference_item 0.85 ["reference content label: 4. Colegate-Stone T, Allom R, Singh R, Elias DA, Standring S"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
124 7 5 reference_content 5. Docimo S Jr, Kornitsky D, Futterman B, Elkowitz DE. Surgical treatment for acromioclavicular joint osteoarthritis: patient selection, surgical options, complications, and outcome. Curr Rev Musculos [113.0, 231.0, 587.0, 307.0] reference_item 0.85 ["reference content label: 5. Docimo S Jr, Kornitsky D, Futterman B, Elkowitz DE. Surgi"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
125 7 6 reference_content 6. Heers G, Götz J, Schachner H, Neumaier U, Grifka J, Hedtmann A. Ultrasound evaluation of the acromioclavicular joint. A comparison with magnetic resonance imaging. Sportverletz Sportschaden 2005;19 [113.0, 311.0, 587.0, 388.0] reference_item 0.85 ["reference content label: 6. Heers G, G\u00f6tz J, Schachner H, Neumaier U, Grifka J, Hedtm"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
126 7 7 reference_content 7. Hossain S, Jacobs LG, Hashmi R. The long-term effectiveness of steroid injections in primary acromioclavicular joint arthritis: a five-year prospective study. J Shoulder Elbow Surg 2008;17:535-8. h [113.0, 391.0, 588.0, 467.0] reference_item 0.85 ["reference content label: 7. Hossain S, Jacobs LG, Hashmi R. The long-term effectivene"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
127 7 8 reference_content 8. Jordan L, Kenter K, Griffiths H. Relationship between MRI and clinical findings in the acromioclavicular joint. Skeletal Radiol 2002;31:516-21. http://dx.doi.org/10.1007/s00256-002-0530-z [113.0, 471.0, 587.0, 528.0] reference_item 0.85 ["reference content label: 8. Jordan L, Kenter K, Griffiths H. Relationship between MRI"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
128 7 9 reference_content 9. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;159-74. [112.0, 531.0, 588.0, 568.0] reference_item 0.85 ["reference content label: 9. Landis JR, Koch GG. The measurement of observer agreement"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
129 7 10 reference_content 10. Mall NA, Foley E, Chalmers PN, Cole BJ, Romeo AA, Bach BR Jr. Degenerative joint disease of the acromioclavicular joint: a review. Am J Sports Med 2013;41:2684-92. http://dx.doi.org/10.1177/036354 [108.0, 570.0, 587.0, 646.0] reference_item 0.85 ["reference content label: 10. Mall NA, Foley E, Chalmers PN, Cole BJ, Romeo AA, Bach B"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
130 7 11 reference_content 11. McFarland EG, Garzon-Muvdi J, Jia X, Desai P, Petersen SA. Clinical and diagnostic tests for shoulder disorders: a critical review. Br J Sports Med 2010;44:328-32. http://dx.doi.org/10.1136/bjsm.2 [108.0, 650.0, 586.0, 725.0] reference_item 0.85 ["reference content label: 11. McFarland EG, Garzon-Muvdi J, Jia X, Desai P, Petersen S"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
131 7 12 reference_content 12. Menge TJ, Boykin RE, Bushnell BD, Byram IR. Acromioclavicular osteoarthritis: a common cause of shoulder pain. South Med J 2014;107:324-9. http://dx.doi.org/10.1097/SMJ.0000000000000101 [107.0, 730.0, 588.0, 787.0] reference_item 0.85 ["reference content label: 12. Menge TJ, Boykin RE, Bushnell BD, Byram IR. Acromioclavi"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
132 7 13 reference_content 13. O'Brien SJ, Pagnani MJ, Fealy S, McGlynn SR, Wilson JB. The active compression test: a new and effective test for diagnosing labral tears and acromioclavicular joint abnormality. Am J Sports Med 1 [634.0, 111.0, 1113.0, 186.0] reference_item 0.85 ["reference content label: 13. O'Brien SJ, Pagnani MJ, Fealy S, McGlynn SR, Wilson JB. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
133 7 14 reference_content 14. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996;49:1373-9. [634.0, 191.0, 1112.0, 248.0] reference_item 0.85 ["reference content label: 14. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
134 7 15 reference_content 15. Pensak M, Grumet RC, Slabaugh MA, Bach BR. Open versus arthroscopic distal clavicle resection. Arthroscopy 2010;26:697-704. http://dx.doi.org/10.1016/j.arthro.2009.12.007 [634.0, 251.0, 1112.0, 307.0] reference_item 0.85 ["reference content label: 15. Pensak M, Grumet RC, Slabaugh MA, Bach BR. Open versus a"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
135 7 16 reference_content 16. Raynor MB, Kuhn JE. Utility of features of the patient's history in the diagnosis of atraumatic shoulder pain: a systematic review. J Shoulder Elbow Surg 2016;25:688-94. http://dx.doi.org/10.1016/ [633.0, 311.0, 1114.0, 368.0] reference_item 0.85 ["reference content label: 16. Raynor MB, Kuhn JE. Utility of features of the patient's"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
136 7 17 reference_content 17. Schünke M, Schulte E, Schumacher U, Voll M, Wesker K. Anatomische atlas Prometheurs: algemene anatomie en bewegingsapparaat. Stuttgart, Germany: Thieme; 2005. [634.0, 371.0, 1113.0, 428.0] reference_item 0.85 ["reference content label: 17. Sch\u00fcnke M, Schulte E, Schumacher U, Voll M, Wesker K. An"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
137 7 18 reference_content 18. Shubin Stein BE, Ahmad CS, Pfaff CH, Bigliani LU, Levine WN. A comparison of magnetic resonance imaging findings of the acromioclavicular joint in symptomatic versus asymptomatic patients. J Shoul [635.0, 431.0, 1114.0, 527.0] reference_item 0.85 ["reference content label: 18. Shubin Stein BE, Ahmad CS, Pfaff CH, Bigliani LU, Levine"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
138 7 19 reference_content 19. Shubin Stein BE, Wiater JM, Pfaff HC, Bigliani LU, Levine WN. Detection of acromioclavicular joint pathology in asymptomatic shoulders with magnetic resonance imaging. J Shoulder Elbow Surg 2001;1 [633.0, 530.0, 1113.0, 588.0] reference_item 0.85 ["reference content label: 19. Shubin Stein BE, Wiater JM, Pfaff HC, Bigliani LU, Levin"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
139 7 20 reference_content 20. Strobel K, Pfirrmann CW, Zanetti M, Nagy L, Hodler J. MRI features of the acromioclavicular joint that predict pain relief from intraarticular injection. AJR Am J Roentgenol 2003;181:755-60. http: [632.0, 590.0, 1113.0, 666.0] reference_item 0.85 ["reference content label: 20. Strobel K, Pfirrmann CW, Zanetti M, Nagy L, Hodler J. MR"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
140 7 21 reference_content 21. van Riet RP, Goehre T, Bell SN. The long term effect of an intra-articular injection of corticosteroids in the acromioclavicular joint. J Shoulder Elbow Surg 2012;21:376-9. http://dx.doi.org/10.10 [631.0, 669.0, 1114.0, 727.0] reference_item 0.85 ["reference content label: 21. van Riet RP, Goehre T, Bell SN. The long term effect of "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
141 7 22 reference_content 22. Walton J, Mahajan S, Paxinos A, Marshall J, Bryant C, Shnier R, et al. Diagnostic values of tests for acromioclavicular joint pain. J Bone Joint Surg Am 2004;86:807-12. [631.0, 730.0, 1114.0, 786.0] reference_item 0.85 ["reference content label: 22. Walton J, Mahajan S, Paxinos A, Marshall J, Bryant C, Sh"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True

46
audit/23T2B8ZX/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,46 @@
{
"figures": {
"matched_count": 3,
"ambiguous_count": 0,
"unresolved_cluster_count": 0,
"unmatched_asset_count": 0,
"matched": [
{
"figure_number": 1,
"legend_block_id": 4,
"asset_block_ids": [
3
],
"page": 3,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 6,
"asset_block_ids": [
5
],
"page": 4,
"match_type": null
},
{
"figure_number": 2,
"legend_block_id": 4,
"asset_block_ids": [
3
],
"page": 4,
"match_type": null
}
],
"ambiguous": [],
"unresolved": []
},
"tables": {
"matched_count": 0,
"ambiguous_count": 0,
"unmatched_asset_count": 3,
"matched": [],
"ambiguous": []
}
}

1237
audit/23T2B8ZX/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

171
audit/23T2B8ZX/page_risk_summary.json Normal file
View file

@ -0,0 +1,171 @@
{
"pages": [
{
"page": 1,
"risk_score": 5,
"risk_reasons": [
"frontmatter_page"
],
"recommended_audit_targets": [
"frontmatter"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 4,
"risk_reasons": [
"hold_threshold",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"reading_order"
],
"counts": {
"body_paragraph": 19,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 3,
"unknown_structural": 3,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 3,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 7,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 4,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 5,
"reference_item": 0,
"tail_like": 0,
"media_assets": 2,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 0
}
},
{
"page": 5,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 3,
"table_like": 3,
"captions": 3,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 7,
"reference_item": 3,
"tail_like": 1,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 7,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 20,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
2,
3,
4,
5,
6
]
}

193
audit/23T2B8ZX/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,193 @@
{
"candidates": [
{
"block_id": "p6:14",
"page": 6,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:15",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:16",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:17",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:0",
"page": 7,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:1",
"page": 7,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:2",
"page": 7,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:3",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:4",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:5",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:6",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:7",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:8",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:9",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:10",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:11",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:12",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:13",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:14",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:15",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:16",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:17",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:18",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:19",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:20",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:21",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:22",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

265
audit/23T2B8ZX/reference_span_audit.json Normal file
View file

@ -0,0 +1,265 @@
{
"reference_span": {
"status": "ACCEPT",
"span_id": "refspan_001",
"start": {
"page": 6,
"column": 2,
"y": 1214.0,
"block_id": "p6:14"
},
"end": {
"page": 7,
"column": 2,
"y": 730.0,
"block_id": "p7:22"
},
"heading_block_id": "p6:14",
"ordered_block_ids": [
"p6:14",
"p6:15",
"p6:16",
"p6:17",
"p7:3",
"p7:4",
"p7:5",
"p7:6",
"p7:7",
"p7:8",
"p7:9",
"p7:10",
"p7:11",
"p7:12",
"p7:13",
"p7:14",
"p7:15",
"p7:16",
"p7:17",
"p7:18",
"p7:19",
"p7:20",
"p7:21",
"p7:22"
],
"inside_block_ids": [
"p6:14",
"p6:15",
"p6:16",
"p6:17",
"p7:3",
"p7:4",
"p7:5",
"p7:6",
"p7:7",
"p7:8",
"p7:9",
"p7:10",
"p7:11",
"p7:12",
"p7:13",
"p7:14",
"p7:15",
"p7:16",
"p7:17",
"p7:18",
"p7:19",
"p7:20",
"p7:21",
"p7:22"
],
"explicitly_outside_nearby_block_ids": [
"p6:13"
],
"intrusion_candidates": [
{
"block_id": "p6:14",
"page": 6,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:15",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:16",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:17",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:0",
"page": 7,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:1",
"page": 7,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:2",
"page": 7,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:3",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:4",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:5",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:6",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:7",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:8",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:9",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:10",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:11",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:12",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:13",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:14",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:15",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:16",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:17",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:18",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:19",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:20",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:21",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p7:22",
"page": 7,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}
}

535
audit/24YKLTHQ/audit_report.json Normal file
View file

@ -0,0 +1,535 @@
{
"paper_key": "24YKLTHQ",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:0cdae8e71dffd5f15ee3102bb54c1fc7b19f4a89eae034eda176f74dceb79a55",
"meta_json_hash": "sha256:6dd2bda1014d5643811fc3afcd6976df6b9d1c714ba0a1e4e7d700d3d1f09910",
"blocks_raw_hash": "sha256:59bb1130a36da732c87c5c1267274369185a87e78d1ff350f3b28a989170d220",
"structured_blocks_hash": "sha256:ffe03ad2b971d258ee19cfc3dae8cd06e53bb02c1de78f2c8f35a28c9d47ae86",
"document_structure_hash": "sha256:a25f440e72f0f6ee73b32a4dd660e200c88af0aa3ac67d87eae96a245409e706",
"figure_inventory_hash": "sha256:2aa3c9d6f203c4a9aad489233e8f64122f4522f49734048deb417109359ce068",
"table_inventory_hash": "sha256:bf1eb7bdc3c7914ae75086870f84ffaa769b903ab6d6ba7539a65d151b614381",
"reader_figures_hash": "sha256:85e406a8972e5966cd23032ce7c6a250b34f8da2cf6a7c7e36d589db42fe00c1",
"resolved_metadata_hash": "sha256:22b2cc0ac117378a10f4e1890b0ede297668036ceff39d4c8fd21265456480da",
"fulltext_hash": "sha256:8b043976b53d353fd8507fe67d5280927ddb6f7f4f47974ce1ccd41aa18c977b",
"block_trace_hash": "sha256:690ec2e7f8ba388badce8c9133afca38fb17ff42dcc717e75e4d4c5215a47612",
"annotated_pages": {
"page_001.png": "sha256:a593cc5ed9b90289961ad3abe95bc23fc427412e9e08fb827969b301de96bcac",
"page_002.png": "sha256:6f27667a3b7d5be4c4191724dd8ad74b31b8c8785dd719e1ff18e2278743d466",
"page_003.png": "sha256:79578d53e4d28e8705132af4bfc0173ad1b87f7b401103abd0140966cc812db7",
"page_004.png": "sha256:85194ec5620e6e4ce8c263881be435af02710c1231c9e32d5a4e4a198a854951",
"page_005.png": "sha256:fafa94b567756164ae6fe7d75fcc545a2e0dc6a87cc297281124dd7f0145ad57",
"page_006.png": "sha256:35bc057141e6d76c7f802e661437fb498b46279ecfc0c624c8b3b48797a65926",
"page_007.png": "sha256:575b6c8b47ee0b4b36d9b26b56db81560728ca3d196e2bf4a9f03c2c08f2647d",
"page_008.png": "sha256:e8c07a1a9cf4ee274ac5c9c621ccccafc4316f22df856d6f963e9e58eedd4a3d",
"page_009.png": "sha256:bac25523dc6ad67f2775e001ed9151112c714e1ceb4d26ff617fd435ed579d90",
"page_010.png": "sha256:36c94d2fb1c45272823d28bda274f2e23ac1996df861825203bb5a5ede6ac3d4",
"page_011.png": "sha256:b712e2094998432a68cf90109551c07b64d308622bea5eae2160cb8c8ff02040",
"page_012.png": "sha256:57602e13fd82852378ed69ff10dd76432c2d54abbe35ebfea3857c73d0151025",
"page_013.png": "sha256:ea2c5694243d61fc873a5db4cae4a444b14411ed2dfd5634b6e0643edcd95b84"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png",
"page_008.png",
"page_009.png",
"page_010.png",
"page_011.png",
"page_012.png",
"page_013.png"
]
},
"reviewed_pages": [
1,
3,
4,
5,
6,
7,
8,
10
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p1:19",
"p1:20",
"p1:21",
"p1:22",
"p1:23",
"p3:0",
"p3:1",
"p3:2",
"p3:3",
"p3:4",
"p3:5",
"p3:6",
"p3:7",
"p3:8",
"p3:9",
"p3:10",
"p4:0",
"p4:1",
"p4:2",
"p4:3",
"p4:4",
"p4:5",
"p4:6",
"p4:7",
"p4:8",
"p4:9",
"p4:10",
"p4:11",
"p4:12",
"p4:13",
"p4:14",
"p4:15",
"p5:0",
"p5:1",
"p5:2",
"p5:3",
"p5:4",
"p5:5",
"p5:6",
"p5:7",
"p5:8",
"p5:9",
"p5:10",
"p5:11",
"p5:12",
"p5:13",
"p5:14",
"p6:0",
"p6:1",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p6:12",
"p7:0",
"p7:1",
"p7:2",
"p7:3",
"p7:4",
"p7:5",
"p7:6",
"p7:7",
"p7:8",
"p7:9",
"p7:10",
"p7:11",
"p7:12",
"p8:0",
"p8:1",
"p8:2",
"p8:3",
"p8:4",
"p8:5",
"p8:6",
"p8:7",
"p10:0",
"p10:1",
"p10:2",
"p10:3",
"p10:4",
"p10:5",
"p10:6",
"p10:7",
"p10:8",
"p10:9",
"p10:10",
"p10:11",
"p10:12",
"p10:13"
],
"findings": [
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p10:7"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p10:8"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p10:9"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p10:10"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p10:11"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p10:12"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p10:13"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:1"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:2"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:3"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:4"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:5"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:6"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:7"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:8"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:9"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:10"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:11"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:12"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "frontmatter_error",
"severity": "major",
"block_ids": [],
"truth": "page 1 should have clearer frontmatter role resolution",
"pipeline_behavior": "frontmatter page retains elevated unknown_structural density",
"root_cause_hypothesis": "frontmatter anchor or noise routing weakness",
"evidence": {
"annotated_page": "annotated_pages/page_001.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_010.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "object_ownership_error",
"severity": "major",
"block_ids": [],
"truth": "figure/table ownership should map captions and assets coherently",
"pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set",
"root_cause_hypothesis": "caption-to-asset grouping ambiguity",
"evidence": {
"annotated_page": null,
"artifact": "figure_table_ownership_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:6",
"p1:7",
"p1:10",
"p1:18",
"p1:20",
"p1:22",
"p2:1",
"p2:2",
"p2:5",
"p2:6",
"p2:8",
"p3:0",
"p3:2",
"p3:5",
"p3:6",
"p3:10"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

39
audit/24YKLTHQ/audit_report.md Normal file
View file

@ -0,0 +1,39 @@
# OCR Truth Audit Report - 24YKLTHQ
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 3, 4, 5, 6, 7, 8, 10]
- Reviewed blocks: 114
## Findings
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

930
audit/24YKLTHQ/audit_scope.json Normal file
View file

@ -0,0 +1,930 @@
{
"mode": "high-risk",
"selected_pages": [
1,
3,
4,
5,
6,
7,
8,
10
],
"required_block_ids": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p1:19",
"p1:20",
"p1:21",
"p1:22",
"p1:23",
"p3:8",
"p4:3",
"p4:4",
"p4:6",
"p5:4",
"p5:10",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p7:3",
"p7:4",
"p7:5",
"p7:6",
"p7:7",
"p7:8",
"p7:9",
"p7:10",
"p8:6",
"p10:3",
"p10:4",
"p10:5",
"p10:7",
"p10:8",
"p10:9",
"p10:10",
"p10:11",
"p10:12",
"p10:13"
],
"required_blocks": [
{
"block_id": "p1:0",
"page": 1,
"required_reason": [
"frontmatter",
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:1",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:2",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:3",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:4",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:5",
"page": 1,
"required_reason": [
"frontmatter",
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:6",
"page": 1,
"required_reason": [
"frontmatter",
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:7",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:8",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:9",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:10",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:11",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:12",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:13",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:14",
"page": 1,
"required_reason": [
"frontmatter",
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:15",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:16",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:17",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:18",
"page": 1,
"required_reason": [
"frontmatter",
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:19",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:20",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:21",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:22",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:23",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p3:8",
"page": 3,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:3",
"page": 4,
"required_reason": [
"object_ownership",
"same_page_boundary"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:4",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:6",
"page": 4,
"required_reason": [
"object_ownership",
"same_page_boundary"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:4",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:10",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:7",
"page": 6,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:8",
"page": 6,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:9",
"page": 6,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:10",
"page": 6,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:11",
"page": 6,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:3",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:4",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:5",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:6",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:7",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:8",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:9",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:10",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p8:6",
"page": 8,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:3",
"page": 10,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:4",
"page": 10,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:5",
"page": 10,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:7",
"page": 10,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:8",
"page": 10,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:9",
"page": 10,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:10",
"page": 10,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:11",
"page": 10,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:12",
"page": 10,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:13",
"page": 10,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
}
],
"selected_page_requirements": [
{
"page": 1,
"must_review_page": true,
"required_block_count": 24
},
{
"page": 3,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 4,
"must_review_page": true,
"required_block_count": 3
},
{
"page": 5,
"must_review_page": true,
"required_block_count": 2
},
{
"page": 6,
"must_review_page": true,
"required_block_count": 5
},
{
"page": 7,
"must_review_page": true,
"required_block_count": 8
},
{
"page": 8,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 10,
"must_review_page": true,
"required_block_count": 10
}
]
}

3676
audit/24YKLTHQ/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

224
audit/24YKLTHQ/block_trace.csv Normal file
View file

@ -0,0 +1,224 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,header_image,,"[174.0, 145.0, 275.0, 268.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True
1,1,header,VISIÓN ELECTRÓNICA VOL. 14 NO. 1 (2020) ● JANUARY ● P.P. 6-18 ● ISSN 1909-9746 ● ISSN-E 2248-4728 ● Bogotá (Colombia),"[109.0, 94.0, 996.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,2,header,"UNIVERSIDAD DISTRITAL
FRANCISCO JOSE DE CALDAS","[135.0, 272.0, 311.0, 309.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,3,header,"Vision Electrónica
Más que un estado sólido","[398.0, 157.0, 719.0, 224.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,4,header,https://doi.org/10.14483/issn.2248-4728,"[382.0, 241.0, 723.0, 263.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,5,image,,"[831.0, 147.0, 1044.0, 272.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True
1,6,text,VISIÓN ELECTRÓNICA,"[820.0, 280.0, 1054.0, 308.0]",unknown_structural,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,True
1,7,text,A RESEARCH VISION,"[924.0, 338.0, 1107.0, 359.0]",authors,0.6,"[""page-1 initial-lastname author byline: A RESEARCH VISION""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True
1,8,doc_title,The effect of frequency in the electrical stimulation of chondrocytes,"[225.0, 356.0, 1011.0, 412.0]",paper_title,0.6,"[""page-1 frontmatter title guard: The effect of frequency in the electrical stimulation of cho""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True
1,9,text,El efecto de la frecuencia en la estimulación eléctrica de condrocitos,"[201.0, 413.0, 1047.0, 445.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True
1,10,text,"Juan Jairo Vaca-González $ ^{ID1} $, Juan Felipe Escobar-Huertas $ ^{ID2} $, Diego Alexander Garzón-Alvarado $ ^{ID3} $","[110.0, 459.0, 1130.0, 486.0]",authors,0.8,"[""page-1 zone author_zone: Juan Jairo Vaca-Gonz\u00e1lez $ ^{ID1} $, Juan Felipe Escobar-Hue""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True
1,11,paragraph_title,INFORMACIÓN DEL ARTÍCULO,"[111.0, 507.0, 380.0, 531.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: INFORMACI\u00d3N DEL ART\u00cdCULO""]",section_heading,0.5,body_zone,heading_like,none,True,True
1,12,text,"Historia del artículo:
Enviado: 03/04/2020
Recibido: 17/04/2020
Aceptado: 28/05/2020","[111.0, 544.0, 293.0, 638.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,13,text,"Keywords:
Cartilage Explants
Chondrocytes
Computational model
Electric Fields
Frequency Dependence
Scaffolds","[110.0, 666.0, 288.0, 828.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords:\nCartilage Explants\nChondrocytes\nComputational mode""]",frontmatter_noise,0.7,body_zone,body_like,none,False,False
1,14,image,,"[114.0, 868.0, 270.0, 924.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
1,15,text,"Palabras clave:
Explantes de Cartílago
Condrocitos
Modelo Computacional
Campos Eléctricos
Dependencia de la Frecuencia
Andamios","[109.0, 964.0, 341.0, 1125.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,16,paragraph_title,ABSTRACT,"[442.0, 506.0, 543.0, 527.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True
1,17,abstract,"Electrical stimulation is a non-invasive therapy used to stimulate chondrocyte dynamics: proliferation, migration, morphology and molecular synthesis. Some studies have evidenced the role of frequency","[439.0, 536.0, 1117.0, 916.0]",body_paragraph,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,body_zone,body_like,none,True,True
1,18,paragraph_title,RESUMEN,"[442.0, 924.0, 534.0, 944.0]",unknown_structural,0.6,"[""author byline on page 1, assigned as authors: RESUMEN""]",authors,0.6,body_zone,heading_like,short_fragment,False,True
1,19,text,"La estimulación eléctrica es una terapia no invasiva utilizada para estimular la dinámica de los condrocitos: proliferación, migración, morfología y síntesis molecular. Algunos estudios han evidenciad","[438.0, 958.0, 1116.0, 1385.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,20,footnote," $ ^{1} $School of Health and Sports Sciences, Fundación Universitaria del Área Andina, Bogotá, Colombia. E-mail: jvaca8@areandina.edu.co","[137.0, 1385.0, 1086.0, 1406.0]",footnote,0.7,"[""footnote label: $ ^{1} $School of Health and Sports Sciences, Fundaci\u00f3n Univ""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True
1,21,footnote,"²Research group in Design, Analysis and Development of Engineering Systems – GIDAD, Fundación Universitaria Los Libertadores, Bogotá, Colombia. E-mail: jfescobarh@libertadores.edu.co","[112.0, 1405.0, 1113.0, 1438.0]",footnote,0.7,"[""footnote label: \u00b2Research group in Design, Analysis and Development of Engin""]",footnote,0.7,body_zone,body_like,none,True,True
1,22,footnote," $ ^{3} $Modeling and Numerical Methods in Engineering Research Group (GNUM) and Biomimetics Laboratory, Biotechnology Institute, Universidad Nacional de Colombia, Bogotá, Colombia. E-mail: dagarzona@","[109.0, 1439.0, 1114.0, 1475.0]",footnote,0.7,"[""footnote label: $ ^{3} $Modeling and Numerical Methods in Engineering Resear""]",footnote,0.7,body_zone,body_like,affiliation_marker,True,True
1,23,footnote,"Cité this article as: J. J. Vaca-González, J. F. Escobar-Huertas and D. A. Garzón-Alvarado, “The effect of frequency in the electrical stimulation of chondrocytes”, Vision electronica, vol. 14, no. 1,","[109.0, 1475.0, 1107.0, 1516.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Cit\u00e9 this article as: J. J. Vaca-Gonz\u00e1lez, J. F. Escobar-Hue""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False
2,0,number,7,"[111.0, 100.0, 125.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False
2,1,header,"J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO","[590.0, 95.0, 1115.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
2,2,paragraph_title,1. Introduction,"[108.0, 151.0, 285.0, 175.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,frontmatter_side_zone,heading_like,heading_numbered,True,True
2,3,text,"Hyaline cartilage is an avascular tissue composed by a single cell type, the chondrocyte [1]. This cell is responsible for synthesizing the main macromolecules located in the cartilaginous tissue: col","[106.0, 204.0, 607.0, 566.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,4,text,"Considering that hyaline cartilage responds to external biophysical stimuli, it has been demonstrated that tissue dynamics are modified when electric fields (EFs) are applied. For instance, in vitro a","[106.0, 589.0, 606.0, 1264.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,5,text,"the charging time of the cell membrane; therefore, cells immersed in this kind of medium need to be stimulated with higher EFs to induce electroporation in the cell membrane [25]. In a study carried o","[106.0, 1262.0, 606.0, 1432.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,6,text,"of the transmembrane potential on prolate and oblate
spheroidal cells stimulated with EFs. Results evidenced
that the transmembrane potential strongly depends on
the cell orientation when a cell is be","[614.0, 151.0, 1117.0, 441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,7,text,"Even though the computational models evidenced that transmembrane potential vary according to cell shape, size and orientation, the models did not consider different frequencies and dielectric propert","[614.0, 470.0, 1118.0, 1428.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,8,footer,Universidad Distrital Francisco José de Caldas - Facultad tecnológica,"[594.0, 1477.0, 1115.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
3,0,header,THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES,"[108.0, 96.0, 640.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
3,1,number,8,"[1100.0, 100.0, 1113.0, 114.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,2,text,"to the ossification of the explant. The findings derived from this computational model could be used to estimate the EFs desired to trigger intracellular responses from the cell. In fact, it has been ","[106.0, 144.0, 606.0, 410.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,3,paragraph_title,2. Materials and Methods,"[107.0, 437.0, 393.0, 461.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,4,paragraph_title,2.1. Geometrical models and boundary conditions,"[107.0, 480.0, 565.0, 505.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Geometrical models and boundary conditions""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,5,text,"A bi-dimensional axisymmetric domain was implemented to represent the capacitive coupled system. The capacitive coupled system is composed of two parallel stainless-steel electrodes, which are located","[106.0, 524.0, 607.0, 646.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,6,text,"media and biological samples were placed within the
culture well plate, respectively (Figure 1). In this study,
biological samples were modelled using two different well
plate dimensions according to p","[614.0, 144.0, 1117.0, 624.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,7,figure_title,Figure 1: Geometries used for computational simulations. A) Culture well plate used for electrical stimulations. B) Three-dimensional representative scheme of the three culture systems simulated. C) R,"[106.0, 657.0, 1115.0, 730.0]",figure_caption,0.92,"[""figure_title label: Figure 1: Geometries used for computational simulations. A) ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
3,8,image,,"[120.0, 760.0, 1096.0, 1389.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,9,figure_title,Source: own,"[556.0, 1423.0, 668.0, 1445.0]",figure_caption,0.85,"[""figure_title label: Source: own""]",figure_caption,0.85,body_zone,body_like,short_fragment,True,True
3,10,footer,Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia),"[110.0, 1477.0, 1040.0, 1499.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
4,0,number,9,"[111.0, 100.0, 125.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,1,header,"J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO","[590.0, 95.0, 1114.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
4,2,figure_title,Table 1: Dielectric properties and measurements of the capacitive coupled system.,"[245.0, 160.0, 977.0, 184.0]",table_caption,0.9,"[""table prefix matched: Table 1: Dielectric properties and measurements of the capac""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True
4,3,table,"<table><tr><td>Component</td><td>Parameter</td><td>Value</td><td>Reference</td></tr><tr><td rowspan=""5"">Stainless-steel electrode</td><td>Separation</td><td>20 [mm]</td><td rowspan=""3"">[21]</td></tr><","[309.0, 208.0, 915.0, 554.0]",media_asset,0.85,"[""media label: table""]",media_asset,0.85,body_zone,unknown_like,none,True,True
4,4,figure_title,Source: own,"[557.0, 560.0, 668.0, 581.0]",figure_caption_candidate,0.85,"[""figure_title label: Source: own""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False
4,5,figure_title,Table 2: Dielectric constants of the biological samples.,"[366.0, 598.0, 856.0, 623.0]",table_caption,0.9,"[""table prefix matched: Table 2: Dielectric constants of the biological samples.""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True
4,6,table,"<table><tr><td rowspan=""2"" colspan=""2""></td><td colspan=""6"">Frequency (kHz)</td><td rowspan=""2"">Reference</td></tr><tr><td>0.01</td><td>1</td><td>10</td><td>50</td><td>100</td><td>1000</td></tr><tr><t","[198.0, 645.0, 1027.0, 973.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,unknown_like,none,True,True
4,7,figure_title,Source: own,"[556.0, 984.0, 669.0, 1005.0]",figure_caption,0.85,"[""figure_title label: Source: own""]",figure_caption,0.85,body_zone,body_like,short_fragment,True,True
4,8,paragraph_title,2.2. Estimation of EFs in chondrocytes cultured in monolayer,"[110.0, 1030.0, 605.0, 1077.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Estimation of EFs in chondrocytes cultured in monolayer""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,9,text,"An axisymmetric monolayer culture with a single chondrocyte was simulated (Figure 2A). The chondrocyte, completely attached to the bottom of a 6 well plate, was modelled considering an ellipsoidal mor","[106.0, 1101.0, 606.0, 1293.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,10,paragraph_title,2.3. Estimation of EFs in hyaline cartilage explants,"[108.0, 1328.0, 579.0, 1353.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Estimation of EFs in hyaline cartilage explants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,11,text,"The cartilage explant, cultured in a 6 well plate, was simulated as an axisymmetric model (Figure 2B). The explant was composed by two specialized tissues: the bone (diaphysis) and the cartilage (epip","[107.0, 1374.0, 605.0, 1447.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,12,text,"the bone (diaphysis) and the cartilage (epiphysis). The
bone dimensions were 3.2 mm of length and 0.5 mm of
thickness, while the cartilage dimensions were 2.5 mm
and 1.5 mm for length and thickness, r","[615.0, 1030.0, 1117.0, 1270.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,13,paragraph_title,2.4. Estimation of EFs in chondrogenic scaffolds,"[618.0, 1306.0, 1060.0, 1329.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Estimation of EFs in chondrogenic scaffolds""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,14,text,"The chondrogenic scaffold, cultured in a 48 well plate, was simulated as an axisymmetric model (Figure 2C). The chondrogenic scaffold was composed by a mixture of two biocompatible polymers: hyaluroni","[616.0, 1351.0, 1116.0, 1447.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,15,footer,Universidad Distrital Francisco José de Caldas - Facultad tecnológica,"[594.0, 1478.0, 1114.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
5,0,header,THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES,"[109.0, 96.0, 640.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
5,1,number,10,"[1092.0, 100.0, 1113.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,2,text,"and gelatin. The scaffold was simulated as a drop with a radius of 3.5 mm with chondrocytes of 10 $ \mu $m located at the bottom, middle and upper surface of the three-dimensional construct (Figure 2","[107.0, 145.0, 607.0, 313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,3,text,Figure 2: Meshes of the three different culture systems simulated in the study. A) Culture system used to stimulate a single chondrocyte cultured in monolayer. B) Culture system implemented to stimula,"[108.0, 355.0, 606.0, 525.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 2: Meshes of the three different culture systems simu""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True
5,4,image,,"[116.0, 541.0, 596.0, 1069.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,5,figure_title,Source: own,"[302.0, 1081.0, 414.0, 1103.0]",figure_caption,0.85,"[""figure_title label: Source: own""]",figure_caption,0.85,body_zone,body_like,short_fragment,True,True
5,6,paragraph_title,2.5. Model implementation,"[109.0, 1138.0, 365.0, 1163.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Model implementation""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
5,7,text,"The procedures to simulate the effect generated by EF's on a single cell, a cartilage explant and a scaffold are described in figure 3. First, an axisymmetric model was selected to represent the domai","[107.0, 1182.0, 606.0, 1448.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,8,text,"temperature and pressure, were assigned within the
model. Once the domains were restricted, the material
properties ϵ and σ were defined for each component of
the model. Then, the equation for EFs was ","[616.0, 145.0, 1116.0, 360.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,9,figure_title,Figure 3: Flowchart of the computational model implementation.,"[616.0, 397.0, 1115.0, 446.0]",figure_caption,0.92,"[""figure_title label: Figure 3: Flowchart of the computational model implementatio""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
5,10,image,,"[618.0, 466.0, 1107.0, 1115.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
5,11,paragraph_title,3. Results,"[619.0, 1144.0, 742.0, 1168.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
5,12,paragraph_title,3.1. EFs distribution in monolayer cultures,"[618.0, 1188.0, 1016.0, 1212.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. EFs distribution in monolayer cultures""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
5,13,text,"The flow of the EFs through the monolayer cell culture system is completely homogeneous, specially within the chondrocytes and the cell culture media where the cells were attached (Figure 4A). Results","[616.0, 1231.0, 1117.0, 1448.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,14,footer,Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia),"[110.0, 1478.0, 1040.0, 1499.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
6,0,number,11,"[110.0, 100.0, 132.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,1,header,"J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO","[590.0, 95.0, 1115.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
6,2,text,"the culture media (Figure 4B). Regarding the EFs in the cytoplasm of the chondrocyte, EFs of 0.02 mV/cm for 1 kHz were observed, while EFs of 1.9 mV/cm for 100 kHz were perceived (Figure 4C). Finally,","[106.0, 145.0, 607.0, 384.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,3,paragraph_title,3.2. EFs distribution in cartilage explants,"[109.0, 413.0, 495.0, 437.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. EFs distribution in cartilage explants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
6,4,text,"A heterogeneous EF distribution was observed inside the explant (Figure 5A). Results evidenced an increase of EFs in stimulated explants as the frequency was higher; in fact, the EFs inside the cultur","[106.0, 457.0, 607.0, 699.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,5,text,"were evidenced at the base of the bone. The EFs in the
middle of the bone were 3 mV/cm for1 kHz and 11.8
mV/cm for 100 kHz. The EFs near the ossification front
were 3.9 mV/cm for 1 kHz and EFs 21 mV/cm","[614.0, 145.0, 1118.0, 671.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,6,figure_title,Figure 4: Distribution of EFs in a chondrocyte cultured in monolayer. A) Electric flow diagram inside the culture well plate (measurement in mV/cm). B) Distribution of EFs inside the culture media. C),"[107.0, 733.0, 1114.0, 808.0]",figure_caption,0.92,"[""figure_title label: Figure 4: Distribution of EFs in a chondrocyte cultured in m""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
6,7,chart,,"[125.0, 825.0, 601.0, 1109.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,8,chart,,"[616.0, 833.0, 1096.0, 1104.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,9,chart,,"[125.0, 1118.0, 603.0, 1408.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,10,chart,,"[610.0, 1118.0, 1099.0, 1408.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,11,figure_title,Source: own,"[556.0, 1424.0, 669.0, 1445.0]",figure_caption_candidate,0.85,"[""figure_title label: Source: own""]",figure_caption,0.85,body_zone,body_like,short_fragment,False,False
6,12,footer,Universidad Distrital Francisco José de Caldas - Facultad tecnológica,"[594.0, 1477.0, 1115.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
7,0,header,THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES,"[109.0, 96.0, 641.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
7,1,number,12,"[1092.0, 100.0, 1114.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
7,2,figure_title,Figure 5: Distribution of EFs in cartilage explant cultured in vitro. A) Electric flow diagram inside the culture well plate and around the explant (measurement in mV/cm). B) Distribution of EFs insid,"[107.0, 160.0, 1114.0, 306.0]",figure_caption,0.92,"[""figure_title label: Figure 5: Distribution of EFs in cartilage explant cultured ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
7,3,chart,,"[159.0, 334.0, 606.0, 589.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,4,chart,,"[620.0, 336.0, 1062.0, 580.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,5,chart,,"[161.0, 594.0, 603.0, 850.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,6,chart,,"[620.0, 589.0, 1062.0, 844.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,7,chart,,"[161.0, 856.0, 602.0, 1117.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,8,chart,,"[618.0, 853.0, 1061.0, 1110.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,9,chart,,"[159.0, 1119.0, 603.0, 1403.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,10,chart,,"[615.0, 1111.0, 1062.0, 1405.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,11,vision_footnote,Source: own,"[556.0, 1406.0, 669.0, 1428.0]",footnote,0.7,"[""vision_footnote label: Source: own""]",footnote,0.7,body_zone,body_like,short_fragment,True,True
7,12,footer,Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia),"[110.0, 1477.0, 1040.0, 1499.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
8,0,number,13,"[110.0, 100.0, 134.0, 116.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
8,1,header,"J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO","[590.0, 95.0, 1115.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
8,2,paragraph_title,3.3. EFs distribution in scaffolds,"[109.0, 144.0, 415.0, 167.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. EFs distribution in scaffolds""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
8,3,text,"A homogeneous EF flow distribution was evidenced inside the chondrogenic scaffold (Figure 6A). Results evidenced that the EFs tend to increase as the frequency was higher. For instance, the EFs in the","[106.0, 186.0, 607.0, 429.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,4,text,"the EFs within the hydrogel when frequencies of 10 Hz
and 1 GHz were applied. The EFs were also measured in
the cytoplasm of chondrocytes located in three different
positions of the scaffold. The EFs in","[614.0, 145.0, 1116.0, 410.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,5,figure_title,Figure 6: Distribution of EFs in scaffold cultured in vitro. A) Electric flow diagram inside the culture well plate and around the scaffold (measurement in mV/cm). B) Distribution of EFs inside the cu,"[107.0, 458.0, 1114.0, 579.0]",figure_caption,0.92,"[""figure_title label: Figure 6: Distribution of EFs in scaffold cultured in vitro.""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
8,6,chart,,"[159.0, 610.0, 1072.0, 1415.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True
8,7,footer,Universidad Distrital Francisco José de Caldas - Facultad tecnológica,"[594.0, 1477.0, 1114.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
9,0,header,THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES,"[108.0, 96.0, 640.0, 114.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
9,1,number,14,"[1091.0, 100.0, 1114.0, 116.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
9,2,paragraph_title,4. Discussion,"[109.0, 144.0, 263.0, 167.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
9,3,text,"This study presents a computational model that evidences the effects generated by EFs on chondrocytes cultured in three different scenarios: monolayer culture, cartilage explant and chondrogenic scaff","[106.0, 198.0, 608.0, 1133.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,4,text,"Considering the cell membrane as a capacitor, the EF's in this computational model were applied in alternating current (AC). Furthermore, the model considered a variation of the frequencies, because a","[106.0, 1159.0, 607.0, 1449.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,5,text,"Even though the activation of ionic channels of
chondrocytes was not modelled, there are reports that
have demonstrated that the voltage-dependent calcium
channels (VDCC) are responsible to trigger di","[615.0, 173.0, 1118.0, 752.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,6,text,"Depending on the EFs applied and the stimulation time, the in vitro procedures of chondrocytes cultured in monolayer can be modified in order to increase cell proliferation and molecular synthesis. In","[615.0, 778.0, 1118.0, 1424.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,7,footer,Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia),"[110.0, 1477.0, 1040.0, 1499.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
10,0,number,15,"[111.0, 100.0, 132.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
10,1,header,"J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO","[590.0, 95.0, 1115.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
10,2,text,"On the other hand, the EF intensities inside the cytoplasm of chondrocytes immersed in the native tissue were lower compared with the EFs in the extracellular matrix of the cartilage. In fact, the EFs","[106.0, 145.0, 606.0, 720.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,3,text,"Finally, the electrical stimulation on chondrogenic scaffolds evidenced that the distribution of EFs tends to be higher in an extracellular environment compared with the EFs perceived by the cytoplasm","[107.0, 744.0, 607.0, 1272.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
10,4,paragraph_title,5. Conclusions,"[109.0, 1306.0, 277.0, 1328.0]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions""]",section_heading,0.85,tail_nonref_hold_zone,heading_like,heading_numbered,True,True
10,5,text,"Overall, electrical stimulation has proven to influence the cell dynamics in chondrocytes within a monolayer culture, a cartilage explant and a chondrogenic three-dimensional construct. This control i","[106.0, 1351.0, 605.0, 1447.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
10,6,text,"by combining the appropriate input parameters, such
as frequency and voltage. A suitable combination of
these factors can provide the desired results, such as
the increase in cell population, morpholo","[614.0, 145.0, 1118.0, 696.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,7,paragraph_title,References,"[619.0, 728.0, 734.0, 752.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True
10,8,reference_content,"[1] A. Bhosale and J. Richardson, “Articular cartilage: Structure, injuries and review of management”, Br. Med. Bull., vol. 87, no. 1, pp. 77-95, 2008. https://doi.org/10.1093/bmb/ldn025","[621.0, 773.0, 1113.0, 867.0]",reference_item,0.85,"[""reference content label: [1] A. Bhosale and J. Richardson, \u201cArticular cartilage: Stru""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
10,9,reference_content,"[2] J. Vaca-González, M. Gutiérrez, and D. Garzón-Alvarado, “Cartílago articular: estructura, patologías y campos eléctricos como alternativa terapéutica. Revisión de conceptos actuales”, Rev. Colomb.","[620.0, 886.0, 1116.0, 1055.0]",reference_item,0.85,"[""reference content label: [2] J. Vaca-Gonz\u00e1lez, M. Guti\u00e9rrez, and D. Garz\u00f3n-Alvarado, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
10,10,reference_content,"[3] F. Burdan et al., “Morphology and physiology of the epiphyseal growth plate”, Folia Histochem Cytobiol, vol. 47, no. 1, pp. 5-16, 2009. https://doi.org/10.2478/v10042-009-0007-1","[621.0, 1074.0, 1114.0, 1167.0]",reference_item,0.85,"[""reference content label: [3] F. Burdan et al., \u201cMorphology and physiology of the epip""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
10,11,reference_content,"[4] J. Becerra, J. Andrades, E. Guerado, P. Zamora-Navas, J. Lopez-Puertas, and A. Reddi, ""Articular cartilage: structure and regeneration"", Tissue Eng Part B Rev, vol. 16, no. 6, pp. 617-627, 2010. h","[621.0, 1189.0, 1113.0, 1330.0]",reference_item,0.85,"[""reference content label: [4] J. Becerra, J. Andrades, E. Guerado, P. Zamora-Navas, J.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
10,12,reference_content,"[5] E. Mackie, L. Tatarzuch, and M. Mirams, ""The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification"", J Endocrinol,","[620.0, 1351.0, 1115.0, 1445.0]",reference_item,0.85,"[""reference content label: [5] E. Mackie, L. Tatarzuch, and M. Mirams, \""The skeleton: a""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
10,13,footer,Universidad Distrital Francisco José de Caldas - Facultad tecnológica,"[594.0, 1478.0, 1115.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False
11,0,header,The effect of frequency in the electrical stimulation of chondrocytes,"[109.0, 97.0, 640.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
11,1,number,16,"[1092.0, 101.0, 1113.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
11,2,reference_content,"vol. 211, no. 2, pp. 109-121, 2011. https://doi.org/10.1530/JOE-11-0048","[139.0, 146.0, 602.0, 192.0]",reference_item,0.85,"[""reference content label: vol. 211, no. 2, pp. 109-121, 2011. https://doi.org/10.1530/""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
11,3,reference_content,"[6] C. Lee, S. Grad, M. Wimmer, and M. Alini, “The influence of mechanical stimuli on articular cartilage tissue engineering”, in Topics in Tissue Engineering, vol. 2, Davos Platz, Switzerland: Ashamm","[112.0, 211.0, 604.0, 331.0]",reference_item,0.85,"[""reference content label: [6] C. Lee, S. Grad, M. Wimmer, and M. Alini, \u201cThe influence""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,4,reference_content,"[7] Z. Lukacs, “Mucopolysaccharides”, in Laboratory Guide to the Methods in Biochemical Genetics, 1st ed., N. Blau., Ed. Heidelberg: Springer, 2008, pp. 287-325. https://doi.org/10.1007/978-3-540-7669","[112.0, 351.0, 605.0, 469.0]",reference_item,0.85,"[""reference content label: [7] Z. Lukacs, \u201cMucopolysaccharides\u201d, in Laboratory Guide to""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,5,reference_content,"[8] J. S. Temenoff and A. G. Mikos, “Review: Tissue engineering for regeneration of articular cartilage”, Biomaterials, vol. 21, no. 5, pp. 431-440, 2000. https://doi.org/10.1016/S0142-9612(99)00213-6","[112.0, 490.0, 603.0, 586.0]",reference_item,0.85,"[""reference content label: [8] J. S. Temenoff and A. G. Mikos, \u201cReview: Tissue engineer""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,6,reference_content,"[9] P. Armstrong, C. Brighton, and A. Star, ""Capacitively coupled electrical stimulation of bovine growth plate chondrocytes grown in pellet form"", J Orthop Res, vol. 6, no. 2, pp. 265-271, 1988. http","[112.0, 606.0, 605.0, 725.0]",reference_item,0.85,"[""reference content label: [9] P. Armstrong, C. Brighton, and A. Star, \""Capacitively co""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,7,reference_content,"[10] C. T. Brighton, L. Jensen, S. R. Pollack, B. S. Tolin, and C. C. Clark, “Proliferative and synthetic response of bovine growth plate chondrocytes to various capacitively coupled electrical fields","[112.0, 746.0, 604.0, 888.0]",reference_item,0.85,"[""reference content label: [10] C. T. Brighton, L. Jensen, S. R. Pollack, B. S. Tolin, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,8,reference_content,"[11] C. Brighton, G. Pfeffer, and S. Pollack, “In vivo growth plate stimulation in various capacitively coupled electrical fields”, J. Orthop. Res., vol. 1, no. 1, pp. 42-49, 1983. https://doi.org/10.","[113.0, 908.0, 603.0, 1026.0]",reference_item,0.85,"[""reference content label: [11] C. Brighton, G. Pfeffer, and S. Pollack, \u201cIn vivo growt""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,9,reference_content,"[12] C. Brighton and P. Townsend, “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes”, J Orthop Res, vol. 6, no. 4, pp. 552-558, 1988. htt","[113.0, 1049.0, 606.0, 1166.0]",reference_item,0.85,"[""reference content label: [12] C. Brighton and P. Townsend, \u201cIncreased cAMP production""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,10,reference_content,"[13] C. Brighton, A. Unger, and J. Stambough, “In vitro growth of bovine articular cartilage chondrocytes in various capacitively coupled electrical fields”, J Orthop Res, vol. 2, no. 1, pp. 15-22, 19","[112.0, 1188.0, 606.0, 1306.0]",reference_item,0.85,"[""reference content label: [13] C. Brighton, A. Unger, and J. Stambough, \u201cIn vitro grow""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,11,reference_content,"[14] C. Brighton, W. Wang, and C. Clark, ""Up-regulation of matrix in bovine articular cartilage explants by electric fields"", Biochem Biophys Res Commun, vol. 342, no. 2, pp. 556-561, 2006. https://do","[112.0, 1327.0, 605.0, 1445.0]",reference_item,0.85,"[""reference content label: [14] C. Brighton, W. Wang, and C. Clark, \""Up-regulation of m""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,12,reference_content,"[15] C. Brighton, W. Wang, and C. Clark, “The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants”, J Bone Jt. Surg Am, vol. 90, no. 4, pp. 833-848, 2","[622.0, 145.0, 1114.0, 262.0]",reference_item,0.85,"[""reference content label: [15] C. Brighton, W. Wang, and C. Clark, \u201cThe effect of elec""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,13,reference_content,"[16] C. T. Brighton, G. B. Pfeffer, and S. R. Pollack, “In vivo growth plate stimulation in various capacitively coupled electrical fields”, J. Orthop. Res., vol. 1, no. 1, pp. 42-49, 1983. https://do","[621.0, 287.0, 1114.0, 403.0]",reference_item,0.85,"[""reference content label: [16] C. T. Brighton, G. B. Pfeffer, and S. R. Pollack, \u201cIn v""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,14,reference_content,"[17] M. Forgon, V. Vámhidy, and L. Kellényi, “Bone growth accelerated by stimulation of the epiphyseal plate with electric current”, Arch. Orthop. Trauma. Surg., vol. 104, no. 2, pp. 121-124, 1985. ht","[621.0, 428.0, 1114.0, 546.0]",reference_item,0.85,"[""reference content label: [17] M. Forgon, V. V\u00e1mhidy, and L. Kell\u00e9nyi, \u201cBone growth ac""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,15,reference_content,"[18] S. Nakasuji, Y. Morita, and K. Anaka, “Effect of Pulse Electric Field Stimulation on Chondrocytes”, Asian Pacific Conf. Mater. Mech., vol. 1, pp. 13-16, 2009.","[621.0, 569.0, 1115.0, 664.0]",reference_item,0.85,"[""reference content label: [18] S. Nakasuji, Y. Morita, and K. Anaka, \u201cEffect of Pulse ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,16,reference_content,"[19] O. Sato and M. Akai, “Effect of direct-current stimulation on the growth plate”, Arch Orthop Trauma Surg, vol. 109, pp. 9-13, 1989. https://doi.org/10.1007/BF00441903","[621.0, 687.0, 1115.0, 783.0]",reference_item,0.85,"[""reference content label: [19] O. Sato and M. Akai, \u201cEffect of direct-current stimulat""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,17,reference_content,"[20] N. Szasz, H. Hung, S. Sen, and A. Grodzinsky, “Electric field regulation of chondrocyte biosynthesis in agarose gel constructs”, in 49th Annual Meeting of the Orthopaedic Research Society, 2003.","[621.0, 805.0, 1114.0, 901.0]",reference_item,0.85,"[""reference content label: [20] N. Szasz, H. Hung, S. Sen, and A. Grodzinsky, \u201cElectric""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,18,reference_content,"[21] J. J. Vaca-González, J. Escobar, J. Guevara, Y. Hata, G. Gallego Ferrer, and D. A. Garzón-Alvarado, ""Capacitively coupled electrical stimulation of rat chondroepiphysis explants: A histomorphomet","[622.0, 924.0, 1114.0, 1089.0]",reference_item,0.85,"[""reference content label: [21] J. J. Vaca-Gonz\u00e1lez, J. Escobar, J. Guevara, Y. Hata, G""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,19,reference_content,"[22] J. J. Vaca-González, J. Guevara, J. Vega, and D. A. Garzón-Alvarado, ""An in vitro chondrocyte electrical stimulation framework: a methodology to calculate electric fields and modulate proliferati","[621.0, 1114.0, 1115.0, 1280.0]",reference_item,0.85,"[""reference content label: [22] J. J. Vaca-Gonz\u00e1lez, J. Guevara, J. Vega, and D. A. Gar""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,20,reference_content,"[23] W. Wang, Z. Wang, G. Zhang, C. C. Clark, and C. T. Brighton, ""Up-regulation of chondrocyte matrix genes and products by electric fields"", Clin. Orthop. Relat. Res., no. 427 SUPPL., pp. 163-173, 2","[622.0, 1304.0, 1115.0, 1442.0]",reference_item,0.85,"[""reference content label: [23] W. Wang, Z. Wang, G. Zhang, C. C. Clark, and C. T. Brig""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
11,21,footer,Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia),"[110.0, 1478.0, 1039.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
12,0,number,17,"[111.0, 100.0, 133.0, 115.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
12,1,header,"J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO","[591.0, 96.0, 1115.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
12,2,reference_content,"[24] C. Grosse and H. Schwan, “Cellular membrane potentials induced by alternating fields”, Biophys. J., vol. 63, no. 6, pp. 1632-1642, Dec. 1992. https://doi.org/10.1016/S0006-3495(92)81740-X","[112.0, 145.0, 604.0, 239.0]",reference_item,0.85,"[""reference content label: [24] C. Grosse and H. Schwan, \u201cCellular membrane potentials ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,3,reference_content,"[25] T. Kotnik, F. Bobanović, and D. Miklavcic, “Sensitivity of transmembrane voltage induced by applied electric fields-A theoretical analysis”, Bioelectrochemistry Bioenerg., vol. 43, no. 2, pp. 285","[112.0, 254.0, 604.0, 396.0]",reference_item,0.85,"[""reference content label: [25] T. Kotnik, F. Bobanovi\u0107, and D. Miklavcic, \u201cSensitivity""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,4,reference_content,"[26] W. Krassowska and J. C. Neu, “Response of a single cell to an external electric field”, Biophys. J., vol. 66, no. 6, pp. 1768-1776, 1994. https://doi.org/10.1016/S0006-3495(94)80971-3","[114.0, 412.0, 605.0, 507.0]",reference_item,0.85,"[""reference content label: [26] W. Krassowska and J. C. Neu, \u201cResponse of a single cell""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,5,reference_content,"[27] B. Valič et al., “Effect of electric field induced transmembrane potential on spheroidal cells: theory and experiment”, Eur. Biophys. J., vol. 32, no. 6, pp. 519-528, 2003. https://doi.org/10.100","[113.0, 522.0, 604.0, 641.0]",reference_item,0.85,"[""reference content label: [27] B. Vali\u010d et al., \u201cEffect of electric field induced tran""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,6,reference_content,"[28] K. Maswiwat, D. Wachner, and J. Gimsa, “Effects of cell orientation and electric field frequency on the transmembrane potential induced in ellipsoidal cells”, Bioelectrochemistry, vol. 74, no. 1,","[112.0, 657.0, 603.0, 800.0]",reference_item,0.85,"[""reference content label: [28] K. Maswiwat, D. Wachner, and J. Gimsa, \u201cEffects of cell""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,7,reference_content,"[29] J. Gimsa and D. Wachner, “Analytical description of the transmembrane voltage induced on arbitrarily oriented ellipsoidal and cylindrical cells”, Biophys. J., vol. 81, no. 4, pp. 1888-1896, Oct. ","[112.0, 815.0, 603.0, 934.0]",reference_item,0.85,"[""reference content label: [29] J. Gimsa and D. Wachner, \u201cAnalytical description of the""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,8,reference_content,"[30] T. Taghian, D. A. Narmoneva, and A. B. Kogan, ""Modulation of cell function by electric field : a high-resolution analysis"", R. Soc., vol. 12, no. 107, pp. 21-25, 2015. https://doi.org/10.1098/rsi","[112.0, 948.0, 603.0, 1066.0]",reference_item,0.85,"[""reference content label: [30] T. Taghian, D. A. Narmoneva, and A. B. Kogan, \""Modulati""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,9,reference_content,"[31] J. J. Vaca-González, “The effect of electric fields on hyaline cartilage: an in vitro and in silico study”, Universidad Nacional de Colombia, 2019.","[113.0, 1082.0, 604.0, 1154.0]",reference_item,0.85,"[""reference content label: [31] J. J. Vaca-Gonz\u00e1lez, \u201cThe effect of electric fields on ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,10,reference_content,"[32] J. J. Vaca-González et al., “Effect of electrical stimulation on chondrogenic differentiation of mesenchymal stem cells cultured in hyaluronic acid - Gelatin injectable hydrogels”, Bioelectrochem","[113.0, 1170.0, 605.0, 1311.0]",reference_item,0.85,"[""reference content label: [32] J. J. Vaca-Gonz\u00e1lez et al., \u201cEffect of electrical stimu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,11,reference_content,"[33] M. A. Golombeck, H. C. Riedel, and O. Dössel, ""Calculation of the dielectric properties of biological tissue using simple models of cell patches"", Biomed. Tech. Eng., vol. 47, pp. 253-256, 2002. ","[113.0, 1327.0, 604.0, 1444.0]",reference_item,0.85,"[""reference content label: [33] M. A. Golombeck, H. C. Riedel, and O. D\u00f6ssel, \""Calculat""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,12,reference_content,"[34] C. Gabriel, “Compilation of the Dielectric Properties of Body Tissues at RF and Microwave Frequencies.”, London, UK, 1996. https://doi.org/10.21236/ADA303903","[622.0, 145.0, 1113.0, 238.0]",reference_item,0.85,"[""reference content label: [34] C. Gabriel, \u201cCompilation of the Dielectric Properties o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,13,reference_content,"[35] J. F. Escobar, “Evaluación in vitro del efecto de una estimulación con campos magnéticos a condrocitos”, Universidad Nacional de Colombia, 2019.","[622.0, 258.0, 1113.0, 328.0]",reference_item,0.85,"[""reference content label: [35] J. F. Escobar, \u201cEvaluaci\u00f3n in vitro del efecto de una e""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,14,reference_content,"[36] C. Trainito, “Study of cell membrane permeabilization induced by pulsed electric field - electrical modeling and characterization on biochip”, Université Paris-Saclay, 2016.","[621.0, 345.0, 1113.0, 440.0]",reference_item,0.85,"[""reference content label: [36] C. Trainito, \u201cStudy of cell membrane permeabilization i""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,15,reference_content,"[37] C. Litalien and P. Beaulieu, “Molecular Mechanisms of Drug Actions: From Receptors to Effectors”, in Pediatric Critical Care, B. P. Fuhrman and J. J. B. T.-P. C. C. (Fourth E. Zimmerman, Eds. Sai","[621.0, 459.0, 1113.0, 600.0]",reference_item,0.85,"[""reference content label: [37] C. Litalien and P. Beaulieu, \u201cMolecular Mechanisms of D""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,16,reference_content,"[38] C. Matta, R. Zákány, and A. Mobasheri, ""Voltage-dependent calcium channels in chondrocytes: roles in health and disease"", Curr. Rheumatol. Rep., vol. 17, no. 43, pp. 1-11, 2015. https://doi.org/1","[621.0, 619.0, 1114.0, 739.0]",reference_item,0.85,"[""reference content label: [38] C. Matta, R. Z\u00e1k\u00e1ny, and A. Mobasheri, \""Voltage-depende""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,17,reference_content,"[39] J. Xu, W. Wang, C. Clark, and C. Brighton, “Signal transduction in electrically stimulated articular chondrocytes involves translocation of extracellular calcium through voltage-gated channels”, ","[621.0, 757.0, 1114.0, 899.0]",reference_item,0.85,"[""reference content label: [39] J. Xu, W. Wang, C. Clark, and C. Brighton, \u201cSignal tran""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,18,reference_content,"[40] W. A. Catterall, “Voltage-gated calcium channels”, Cold Spring Harb. Perspect. Biol., vol. 3, no. 8, pp. 1-23, Aug. 2011. https://doi.org/10.1101/cshperspect.a003947","[621.0, 916.0, 1114.0, 1012.0]",reference_item,0.85,"[""reference content label: [40] W. A. Catterall, \u201cVoltage-gated calcium channels\u201d, Cold""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,19,reference_content,"[41] T. Ning, K. Zhang, B. C. Heng, and Z. Ge, “Diverse effects of pulsed electrical stimulation on cells - with a focus on chondrocytes and cartilage regeneration”, Cells Mater., vol. 38, pp. 79-83, ","[621.0, 1030.0, 1113.0, 1148.0]",reference_item,0.85,"[""reference content label: [41] T. Ning, K. Zhang, B. C. Heng, and Z. Ge, \u201cDiverse effe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,20,reference_content,"[42] J. F. Escobar, J. J. Vaca-González, J. M. Guevara, and D. A. Garzón-Alvarado, “Effect of magnetic and electric fields on plasma membrane of single cells: A computational approach”, Eng. Reports, ","[621.0, 1167.0, 1114.0, 1308.0]",reference_item,0.85,"[""reference content label: [42] J. F. Escobar, J. J. Vaca-Gonz\u00e1lez, J. M. Guevara, and ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,21,reference_content,"[43] A. Weizel et al., “Numerical simulation of the electric field distribution in an electrical stimulation device for scaffolds settled with cartilaginous cells”, in 2019 41st Annual International C","[621.0, 1328.0, 1115.0, 1446.0]",reference_item,0.85,"[""reference content label: [43] A. Weizel et al., \u201cNumerical simulation of the electric""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
12,22,footer,Universidad Distrital Francisco José de Caldas - Facultad tecnológica,"[594.0, 1478.0, 1115.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
13,0,header,The effect of frequency in the electrical stimulation of chondrocytes,"[109.0, 97.0, 640.0, 113.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
13,1,number,18,"[1092.0, 101.0, 1113.0, 114.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
13,2,reference_content,"(EMBC), 2019, pp. 6481-6484. https://doi.org/10.1109/EMBC.2019.8857760","[141.0, 145.0, 604.0, 190.0]",reference_item,0.85,"[""reference content label: (EMBC), 2019, pp. 6481-6484. https://doi.org/10.1109/EMBC.20""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
13,3,reference_content,"[44] B. Hiemer et al., “Effect of electric stimulation on human chondrocytes and mesenchymal stem cells under normoxia and hypoxia”, Mol. Med. Rep., vol. 18, no. 2, pp. 2133-2141, Aug. 2018. https://d","[113.0, 205.0, 604.0, 321.0]",reference_item,0.85,"[""reference content label: [44] B. Hiemer et al., \u201cEffect of electric stimulation on hu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
13,4,reference_content,"[45] O. Akanji, D. Lee, and D. Bader, “The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs”, Biorheology, vol. 45, no. 3-4, pp. 229-243, 2008. https://do","[622.0, 146.0, 1115.0, 260.0]",reference_item,0.85,"[""reference content label: [45] O. Akanji, D. Lee, and D. Bader, \u201cThe effects of direct""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_bracket,True,True
13,5,footer,Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia),"[110.0, 1478.0, 1040.0, 1498.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 header_image [174.0, 145.0, 275.0, 268.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False True
3 1 1 header VISIÓN ELECTRÓNICA VOL. 14 NO. 1 (2020) ● JANUARY ● P.P. 6-18 ● ISSN 1909-9746 ● ISSN-E 2248-4728 ● Bogotá (Colombia) [109.0, 94.0, 996.0, 114.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
4 1 2 header UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS [135.0, 272.0, 311.0, 309.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
5 1 3 header Vision Electrónica Más que un estado sólido [398.0, 157.0, 719.0, 224.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
6 1 4 header https://doi.org/10.14483/issn.2248-4728 [382.0, 241.0, 723.0, 263.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
7 1 5 image [831.0, 147.0, 1044.0, 272.0] media_asset 0.85 ["media label: image"] media_asset 0.85 frontmatter_main_zone support_like empty True True
8 1 6 text VISIÓN ELECTRÓNICA [820.0, 280.0, 1054.0, 308.0] unknown_structural 0.3 ["short text, uncertain role"] unknown_structural 0.3 frontmatter_main_zone support_like short_fragment False True
9 1 7 text A RESEARCH VISION [924.0, 338.0, 1107.0, 359.0] authors 0.6 ["page-1 initial-lastname author byline: A RESEARCH VISION"] authors 0.6 frontmatter_main_zone support_like short_fragment True True
10 1 8 doc_title The effect of frequency in the electrical stimulation of chondrocytes [225.0, 356.0, 1011.0, 412.0] paper_title 0.6 ["page-1 frontmatter title guard: The effect of frequency in the electrical stimulation of cho"] paper_title 0.6 frontmatter_main_zone support_like none True True
11 1 9 text El efecto de la frecuencia en la estimulación eléctrica de condrocitos [201.0, 413.0, 1047.0, 445.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 frontmatter_main_zone support_like none True True
12 1 10 text Juan Jairo Vaca-González $ ^{ID1} $, Juan Felipe Escobar-Huertas $ ^{ID2} $, Diego Alexander Garzón-Alvarado $ ^{ID3} $ [110.0, 459.0, 1130.0, 486.0] authors 0.8 ["page-1 zone author_zone: Juan Jairo Vaca-Gonz\u00e1lez $ ^{ID1} $, Juan Felipe Escobar-Hue"] authors 0.8 frontmatter_main_zone support_like none True True
13 1 11 paragraph_title INFORMACIÓN DEL ARTÍCULO [111.0, 507.0, 380.0, 531.0] section_heading 0.5 ["unnumbered paragraph_title on page 1 outside title zone: INFORMACI\u00d3N DEL ART\u00cdCULO"] section_heading 0.5 body_zone heading_like none True True
14 1 12 text Historia del artículo: Enviado: 03/04/2020 Recibido: 17/04/2020 Aceptado: 28/05/2020 [111.0, 544.0, 293.0, 638.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
15 1 13 text Keywords: Cartilage Explants Chondrocytes Computational model Electric Fields Frequency Dependence Scaffolds [110.0, 666.0, 288.0, 828.0] frontmatter_noise 0.7 ["frontmatter noise text: Keywords:\nCartilage Explants\nChondrocytes\nComputational mode"] frontmatter_noise 0.7 body_zone body_like none False False
16 1 14 image [114.0, 868.0, 270.0, 924.0] media_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
17 1 15 text Palabras clave: Explantes de Cartílago Condrocitos Modelo Computacional Campos Eléctricos Dependencia de la Frecuencia Andamios [109.0, 964.0, 341.0, 1125.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
18 1 16 paragraph_title ABSTRACT [442.0, 506.0, 543.0, 527.0] abstract_heading 0.95 ["abstract heading"] abstract_heading 0.95 frontmatter_main_zone heading_like short_fragment True True
19 1 17 abstract Electrical stimulation is a non-invasive therapy used to stimulate chondrocyte dynamics: proliferation, migration, morphology and molecular synthesis. Some studies have evidenced the role of frequency [439.0, 536.0, 1117.0, 916.0] body_paragraph 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 body_zone body_like none True True
20 1 18 paragraph_title RESUMEN [442.0, 924.0, 534.0, 944.0] unknown_structural 0.6 ["author byline on page 1, assigned as authors: RESUMEN"] authors 0.6 body_zone heading_like short_fragment False True
21 1 19 text La estimulación eléctrica es una terapia no invasiva utilizada para estimular la dinámica de los condrocitos: proliferación, migración, morfología y síntesis molecular. Algunos estudios han evidenciad [438.0, 958.0, 1116.0, 1385.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
22 1 20 footnote $ ^{1} $School of Health and Sports Sciences, Fundación Universitaria del Área Andina, Bogotá, Colombia. E-mail: jvaca8@areandina.edu.co [137.0, 1385.0, 1086.0, 1406.0] footnote 0.7 ["footnote label: $ ^{1} $School of Health and Sports Sciences, Fundaci\u00f3n Univ"] footnote 0.7 body_zone body_like affiliation_marker True True
23 1 21 footnote ²Research group in Design, Analysis and Development of Engineering Systems – GIDAD, Fundación Universitaria Los Libertadores, Bogotá, Colombia. E-mail: jfescobarh@libertadores.edu.co [112.0, 1405.0, 1113.0, 1438.0] footnote 0.7 ["footnote label: \u00b2Research group in Design, Analysis and Development of Engin"] footnote 0.7 body_zone body_like none True True
24 1 22 footnote $ ^{3} $Modeling and Numerical Methods in Engineering Research Group (GNUM) and Biomimetics Laboratory, Biotechnology Institute, Universidad Nacional de Colombia, Bogotá, Colombia. E-mail: dagarzona@ [109.0, 1439.0, 1114.0, 1475.0] footnote 0.7 ["footnote label: $ ^{3} $Modeling and Numerical Methods in Engineering Resear"] footnote 0.7 body_zone body_like affiliation_marker True True
25 1 23 footnote Cité this article as: J. J. Vaca-González, J. F. Escobar-Huertas and D. A. Garzón-Alvarado, “The effect of frequency in the electrical stimulation of chondrocytes”, Vision electronica, vol. 14, no. 1, [109.0, 1475.0, 1107.0, 1516.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Cit\u00e9 this article as: J. J. Vaca-Gonz\u00e1lez, J. F. Escobar-Hue"] frontmatter_noise 0.8 body_zone body_like none False False
26 2 0 number 7 [111.0, 100.0, 125.0, 115.0] noise 0.9 ["page number label"] noise 0.9 frontmatter_side_zone support_like short_fragment False False
27 2 1 header J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO [590.0, 95.0, 1115.0, 114.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
28 2 2 paragraph_title 1. Introduction [108.0, 151.0, 285.0, 175.0] section_heading 0.85 ["paragraph_title label with numbering: 1. Introduction"] section_heading 0.85 frontmatter_side_zone heading_like heading_numbered True True
29 2 3 text Hyaline cartilage is an avascular tissue composed by a single cell type, the chondrocyte [1]. This cell is responsible for synthesizing the main macromolecules located in the cartilaginous tissue: col [106.0, 204.0, 607.0, 566.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
30 2 4 text Considering that hyaline cartilage responds to external biophysical stimuli, it has been demonstrated that tissue dynamics are modified when electric fields (EFs) are applied. For instance, in vitro a [106.0, 589.0, 606.0, 1264.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
31 2 5 text the charging time of the cell membrane; therefore, cells immersed in this kind of medium need to be stimulated with higher EFs to induce electroporation in the cell membrane [25]. In a study carried o [106.0, 1262.0, 606.0, 1432.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
32 2 6 text of the transmembrane potential on prolate and oblate spheroidal cells stimulated with EFs. Results evidenced that the transmembrane potential strongly depends on the cell orientation when a cell is be [614.0, 151.0, 1117.0, 441.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
33 2 7 text Even though the computational models evidenced that transmembrane potential vary according to cell shape, size and orientation, the models did not consider different frequencies and dielectric propert [614.0, 470.0, 1118.0, 1428.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
34 2 8 footer Universidad Distrital Francisco José de Caldas - Facultad tecnológica [594.0, 1477.0, 1115.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
35 3 0 header THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES [108.0, 96.0, 640.0, 114.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
36 3 1 number 8 [1100.0, 100.0, 1113.0, 114.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
37 3 2 text to the ossification of the explant. The findings derived from this computational model could be used to estimate the EFs desired to trigger intracellular responses from the cell. In fact, it has been [106.0, 144.0, 606.0, 410.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
38 3 3 paragraph_title 2. Materials and Methods [107.0, 437.0, 393.0, 461.0] section_heading 0.85 ["paragraph_title label with numbering: 2. Materials and Methods"] section_heading 0.85 body_zone heading_like heading_numbered True True
39 3 4 paragraph_title 2.1. Geometrical models and boundary conditions [107.0, 480.0, 565.0, 505.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.1. Geometrical models and boundary conditions"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
40 3 5 text A bi-dimensional axisymmetric domain was implemented to represent the capacitive coupled system. The capacitive coupled system is composed of two parallel stainless-steel electrodes, which are located [106.0, 524.0, 607.0, 646.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
41 3 6 text media and biological samples were placed within the culture well plate, respectively (Figure 1). In this study, biological samples were modelled using two different well plate dimensions according to p [614.0, 144.0, 1117.0, 624.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
42 3 7 figure_title Figure 1: Geometries used for computational simulations. A) Culture well plate used for electrical stimulations. B) Three-dimensional representative scheme of the three culture systems simulated. C) R [106.0, 657.0, 1115.0, 730.0] figure_caption 0.92 ["figure_title label: Figure 1: Geometries used for computational simulations. A) "] figure_caption 0.92 display_zone legend_like figure_number True True
43 3 8 image [120.0, 760.0, 1096.0, 1389.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
44 3 9 figure_title Source: own [556.0, 1423.0, 668.0, 1445.0] figure_caption 0.85 ["figure_title label: Source: own"] figure_caption 0.85 body_zone body_like short_fragment True True
45 3 10 footer Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia) [110.0, 1477.0, 1040.0, 1499.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
46 4 0 number 9 [111.0, 100.0, 125.0, 115.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
47 4 1 header J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO [590.0, 95.0, 1114.0, 113.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
48 4 2 figure_title Table 1: Dielectric properties and measurements of the capacitive coupled system. [245.0, 160.0, 977.0, 184.0] table_caption 0.9 ["table prefix matched: Table 1: Dielectric properties and measurements of the capac"] table_caption 0.9 display_zone table_caption_like table_number True True
49 4 3 table <table><tr><td>Component</td><td>Parameter</td><td>Value</td><td>Reference</td></tr><tr><td rowspan="5">Stainless-steel electrode</td><td>Separation</td><td>20 [mm]</td><td rowspan="3">[21]</td></tr>< [309.0, 208.0, 915.0, 554.0] media_asset 0.85 ["media label: table"] media_asset 0.85 body_zone unknown_like none True True
50 4 4 figure_title Source: own [557.0, 560.0, 668.0, 581.0] figure_caption_candidate 0.85 ["figure_title label: Source: own"] figure_caption 0.85 body_zone body_like short_fragment False False
51 4 5 figure_title Table 2: Dielectric constants of the biological samples. [366.0, 598.0, 856.0, 623.0] table_caption 0.9 ["table prefix matched: Table 2: Dielectric constants of the biological samples."] table_caption 0.9 display_zone table_caption_like table_number True True
52 4 6 table <table><tr><td rowspan="2" colspan="2"></td><td colspan="6">Frequency (kHz)</td><td rowspan="2">Reference</td></tr><tr><td>0.01</td><td>1</td><td>10</td><td>50</td><td>100</td><td>1000</td></tr><tr><t [198.0, 645.0, 1027.0, 973.0] table_html 0.85 ["media label: table"] media_asset 0.85 body_zone unknown_like none True True
53 4 7 figure_title Source: own [556.0, 984.0, 669.0, 1005.0] figure_caption 0.85 ["figure_title label: Source: own"] figure_caption 0.85 body_zone body_like short_fragment True True
54 4 8 paragraph_title 2.2. Estimation of EFs in chondrocytes cultured in monolayer [110.0, 1030.0, 605.0, 1077.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.2. Estimation of EFs in chondrocytes cultured in monolayer"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
55 4 9 text An axisymmetric monolayer culture with a single chondrocyte was simulated (Figure 2A). The chondrocyte, completely attached to the bottom of a 6 well plate, was modelled considering an ellipsoidal mor [106.0, 1101.0, 606.0, 1293.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
56 4 10 paragraph_title 2.3. Estimation of EFs in hyaline cartilage explants [108.0, 1328.0, 579.0, 1353.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.3. Estimation of EFs in hyaline cartilage explants"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
57 4 11 text The cartilage explant, cultured in a 6 well plate, was simulated as an axisymmetric model (Figure 2B). The explant was composed by two specialized tissues: the bone (diaphysis) and the cartilage (epip [107.0, 1374.0, 605.0, 1447.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
58 4 12 text the bone (diaphysis) and the cartilage (epiphysis). The bone dimensions were 3.2 mm of length and 0.5 mm of thickness, while the cartilage dimensions were 2.5 mm and 1.5 mm for length and thickness, r [615.0, 1030.0, 1117.0, 1270.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
59 4 13 paragraph_title 2.4. Estimation of EFs in chondrogenic scaffolds [618.0, 1306.0, 1060.0, 1329.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.4. Estimation of EFs in chondrogenic scaffolds"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
60 4 14 text The chondrogenic scaffold, cultured in a 48 well plate, was simulated as an axisymmetric model (Figure 2C). The chondrogenic scaffold was composed by a mixture of two biocompatible polymers: hyaluroni [616.0, 1351.0, 1116.0, 1447.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
61 4 15 footer Universidad Distrital Francisco José de Caldas - Facultad tecnológica [594.0, 1478.0, 1114.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
62 5 0 header THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES [109.0, 96.0, 640.0, 114.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
63 5 1 number 10 [1092.0, 100.0, 1113.0, 115.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
64 5 2 text and gelatin. The scaffold was simulated as a drop with a radius of 3.5 mm with chondrocytes of 10 $ \mu $m located at the bottom, middle and upper surface of the three-dimensional construct (Figure 2 [107.0, 145.0, 607.0, 313.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
65 5 3 text Figure 2: Meshes of the three different culture systems simulated in the study. A) Culture system used to stimulate a single chondrocyte cultured in monolayer. B) Culture system implemented to stimula [108.0, 355.0, 606.0, 525.0] body_paragraph 0.9 ["figure caption candidate (body narrative): Figure 2: Meshes of the three different culture systems simu"] figure_caption_candidate 0.9 display_zone legend_like figure_number True True
66 5 4 image [116.0, 541.0, 596.0, 1069.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
67 5 5 figure_title Source: own [302.0, 1081.0, 414.0, 1103.0] figure_caption 0.85 ["figure_title label: Source: own"] figure_caption 0.85 body_zone body_like short_fragment True True
68 5 6 paragraph_title 2.5. Model implementation [109.0, 1138.0, 365.0, 1163.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.5. Model implementation"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
69 5 7 text The procedures to simulate the effect generated by EF's on a single cell, a cartilage explant and a scaffold are described in figure 3. First, an axisymmetric model was selected to represent the domai [107.0, 1182.0, 606.0, 1448.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
70 5 8 text temperature and pressure, were assigned within the model. Once the domains were restricted, the material properties ϵ and σ were defined for each component of the model. Then, the equation for EFs was [616.0, 145.0, 1116.0, 360.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
71 5 9 figure_title Figure 3: Flowchart of the computational model implementation. [616.0, 397.0, 1115.0, 446.0] figure_caption 0.92 ["figure_title label: Figure 3: Flowchart of the computational model implementatio"] figure_caption 0.92 display_zone legend_like figure_number True True
72 5 10 image [618.0, 466.0, 1107.0, 1115.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone body_like empty True True
73 5 11 paragraph_title 3. Results [619.0, 1144.0, 742.0, 1168.0] section_heading 0.85 ["paragraph_title label with numbering: 3. Results"] section_heading 0.85 body_zone heading_like heading_numbered True True
74 5 12 paragraph_title 3.1. EFs distribution in monolayer cultures [618.0, 1188.0, 1016.0, 1212.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.1. EFs distribution in monolayer cultures"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
75 5 13 text The flow of the EFs through the monolayer cell culture system is completely homogeneous, specially within the chondrocytes and the cell culture media where the cells were attached (Figure 4A). Results [616.0, 1231.0, 1117.0, 1448.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
76 5 14 footer Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia) [110.0, 1478.0, 1040.0, 1499.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
77 6 0 number 11 [110.0, 100.0, 132.0, 115.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
78 6 1 header J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO [590.0, 95.0, 1115.0, 113.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
79 6 2 text the culture media (Figure 4B). Regarding the EFs in the cytoplasm of the chondrocyte, EFs of 0.02 mV/cm for 1 kHz were observed, while EFs of 1.9 mV/cm for 100 kHz were perceived (Figure 4C). Finally, [106.0, 145.0, 607.0, 384.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
80 6 3 paragraph_title 3.2. EFs distribution in cartilage explants [109.0, 413.0, 495.0, 437.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.2. EFs distribution in cartilage explants"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
81 6 4 text A heterogeneous EF distribution was observed inside the explant (Figure 5A). Results evidenced an increase of EFs in stimulated explants as the frequency was higher; in fact, the EFs inside the cultur [106.0, 457.0, 607.0, 699.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
82 6 5 text were evidenced at the base of the bone. The EFs in the middle of the bone were 3 mV/cm for1 kHz and 11.8 mV/cm for 100 kHz. The EFs near the ossification front were 3.9 mV/cm for 1 kHz and EFs 21 mV/cm [614.0, 145.0, 1118.0, 671.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
83 6 6 figure_title Figure 4: Distribution of EFs in a chondrocyte cultured in monolayer. A) Electric flow diagram inside the culture well plate (measurement in mV/cm). B) Distribution of EFs inside the culture media. C) [107.0, 733.0, 1114.0, 808.0] figure_caption 0.92 ["figure_title label: Figure 4: Distribution of EFs in a chondrocyte cultured in m"] figure_caption 0.92 display_zone legend_like figure_number True True
84 6 7 chart [125.0, 825.0, 601.0, 1109.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
85 6 8 chart [616.0, 833.0, 1096.0, 1104.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
86 6 9 chart [125.0, 1118.0, 603.0, 1408.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
87 6 10 chart [610.0, 1118.0, 1099.0, 1408.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
88 6 11 figure_title Source: own [556.0, 1424.0, 669.0, 1445.0] figure_caption_candidate 0.85 ["figure_title label: Source: own"] figure_caption 0.85 body_zone body_like short_fragment False False
89 6 12 footer Universidad Distrital Francisco José de Caldas - Facultad tecnológica [594.0, 1477.0, 1115.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
90 7 0 header THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES [109.0, 96.0, 641.0, 114.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
91 7 1 number 12 [1092.0, 100.0, 1114.0, 115.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
92 7 2 figure_title Figure 5: Distribution of EFs in cartilage explant cultured in vitro. A) Electric flow diagram inside the culture well plate and around the explant (measurement in mV/cm). B) Distribution of EFs insid [107.0, 160.0, 1114.0, 306.0] figure_caption 0.92 ["figure_title label: Figure 5: Distribution of EFs in cartilage explant cultured "] figure_caption 0.92 display_zone legend_like figure_number True True
93 7 3 chart [159.0, 334.0, 606.0, 589.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
94 7 4 chart [620.0, 336.0, 1062.0, 580.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
95 7 5 chart [161.0, 594.0, 603.0, 850.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
96 7 6 chart [620.0, 589.0, 1062.0, 844.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
97 7 7 chart [161.0, 856.0, 602.0, 1117.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
98 7 8 chart [618.0, 853.0, 1061.0, 1110.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
99 7 9 chart [159.0, 1119.0, 603.0, 1403.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
100 7 10 chart [615.0, 1111.0, 1062.0, 1405.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
101 7 11 vision_footnote Source: own [556.0, 1406.0, 669.0, 1428.0] footnote 0.7 ["vision_footnote label: Source: own"] footnote 0.7 body_zone body_like short_fragment True True
102 7 12 footer Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia) [110.0, 1477.0, 1040.0, 1499.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
103 8 0 number 13 [110.0, 100.0, 134.0, 116.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
104 8 1 header J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO [590.0, 95.0, 1115.0, 113.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
105 8 2 paragraph_title 3.3. EFs distribution in scaffolds [109.0, 144.0, 415.0, 167.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.3. EFs distribution in scaffolds"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
106 8 3 text A homogeneous EF flow distribution was evidenced inside the chondrogenic scaffold (Figure 6A). Results evidenced that the EFs tend to increase as the frequency was higher. For instance, the EFs in the [106.0, 186.0, 607.0, 429.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
107 8 4 text the EFs within the hydrogel when frequencies of 10 Hz and 1 GHz were applied. The EFs were also measured in the cytoplasm of chondrocytes located in three different positions of the scaffold. The EFs in [614.0, 145.0, 1116.0, 410.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
108 8 5 figure_title Figure 6: Distribution of EFs in scaffold cultured in vitro. A) Electric flow diagram inside the culture well plate and around the scaffold (measurement in mV/cm). B) Distribution of EFs inside the cu [107.0, 458.0, 1114.0, 579.0] figure_caption 0.92 ["figure_title label: Figure 6: Distribution of EFs in scaffold cultured in vitro."] figure_caption 0.92 display_zone legend_like figure_number True True
109 8 6 chart [159.0, 610.0, 1072.0, 1415.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone body_like empty True True
110 8 7 footer Universidad Distrital Francisco José de Caldas - Facultad tecnológica [594.0, 1477.0, 1114.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
111 9 0 header THE EFFECT OF FREQUENCY IN THE ELECTRICAL STIMULATION OF CHONDROCYTES [108.0, 96.0, 640.0, 114.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
112 9 1 number 14 [1091.0, 100.0, 1114.0, 116.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
113 9 2 paragraph_title 4. Discussion [109.0, 144.0, 263.0, 167.0] section_heading 0.85 ["paragraph_title label with numbering: 4. Discussion"] section_heading 0.85 body_zone heading_like heading_numbered True True
114 9 3 text This study presents a computational model that evidences the effects generated by EFs on chondrocytes cultured in three different scenarios: monolayer culture, cartilage explant and chondrogenic scaff [106.0, 198.0, 608.0, 1133.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
115 9 4 text Considering the cell membrane as a capacitor, the EF's in this computational model were applied in alternating current (AC). Furthermore, the model considered a variation of the frequencies, because a [106.0, 1159.0, 607.0, 1449.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
116 9 5 text Even though the activation of ionic channels of chondrocytes was not modelled, there are reports that have demonstrated that the voltage-dependent calcium channels (VDCC) are responsible to trigger di [615.0, 173.0, 1118.0, 752.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
117 9 6 text Depending on the EFs applied and the stimulation time, the in vitro procedures of chondrocytes cultured in monolayer can be modified in order to increase cell proliferation and molecular synthesis. In [615.0, 778.0, 1118.0, 1424.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
118 9 7 footer Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia) [110.0, 1477.0, 1040.0, 1499.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
119 10 0 number 15 [111.0, 100.0, 132.0, 115.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
120 10 1 header J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO [590.0, 95.0, 1115.0, 113.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
121 10 2 text On the other hand, the EF intensities inside the cytoplasm of chondrocytes immersed in the native tissue were lower compared with the EFs in the extracellular matrix of the cartilage. In fact, the EFs [106.0, 145.0, 606.0, 720.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
122 10 3 text Finally, the electrical stimulation on chondrogenic scaffolds evidenced that the distribution of EFs tends to be higher in an extracellular environment compared with the EFs perceived by the cytoplasm [107.0, 744.0, 607.0, 1272.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
123 10 4 paragraph_title 5. Conclusions [109.0, 1306.0, 277.0, 1328.0] section_heading 0.85 ["paragraph_title label with numbering: 5. Conclusions"] section_heading 0.85 tail_nonref_hold_zone heading_like heading_numbered True True
124 10 5 text Overall, electrical stimulation has proven to influence the cell dynamics in chondrocytes within a monolayer culture, a cartilage explant and a chondrogenic three-dimensional construct. This control i [106.0, 1351.0, 605.0, 1447.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
125 10 6 text by combining the appropriate input parameters, such as frequency and voltage. A suitable combination of these factors can provide the desired results, such as the increase in cell population, morpholo [614.0, 145.0, 1118.0, 696.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
126 10 7 paragraph_title References [619.0, 728.0, 734.0, 752.0] reference_heading 0.9 ["references heading: References"] reference_heading 0.9 reference_zone heading_like short_fragment True True
127 10 8 reference_content [1] A. Bhosale and J. Richardson, “Articular cartilage: Structure, injuries and review of management”, Br. Med. Bull., vol. 87, no. 1, pp. 77-95, 2008. https://doi.org/10.1093/bmb/ldn025 [621.0, 773.0, 1113.0, 867.0] reference_item 0.85 ["reference content label: [1] A. Bhosale and J. Richardson, \u201cArticular cartilage: Stru"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
128 10 9 reference_content [2] J. Vaca-González, M. Gutiérrez, and D. Garzón-Alvarado, “Cartílago articular: estructura, patologías y campos eléctricos como alternativa terapéutica. Revisión de conceptos actuales”, Rev. Colomb. [620.0, 886.0, 1116.0, 1055.0] reference_item 0.85 ["reference content label: [2] J. Vaca-Gonz\u00e1lez, M. Guti\u00e9rrez, and D. Garz\u00f3n-Alvarado, "] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
129 10 10 reference_content [3] F. Burdan et al., “Morphology and physiology of the epiphyseal growth plate”, Folia Histochem Cytobiol, vol. 47, no. 1, pp. 5-16, 2009. https://doi.org/10.2478/v10042-009-0007-1 [621.0, 1074.0, 1114.0, 1167.0] reference_item 0.85 ["reference content label: [3] F. Burdan et al., \u201cMorphology and physiology of the epip"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
130 10 11 reference_content [4] J. Becerra, J. Andrades, E. Guerado, P. Zamora-Navas, J. Lopez-Puertas, and A. Reddi, "Articular cartilage: structure and regeneration", Tissue Eng Part B Rev, vol. 16, no. 6, pp. 617-627, 2010. h [621.0, 1189.0, 1113.0, 1330.0] reference_item 0.85 ["reference content label: [4] J. Becerra, J. Andrades, E. Guerado, P. Zamora-Navas, J."] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
131 10 12 reference_content [5] E. Mackie, L. Tatarzuch, and M. Mirams, "The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification", J Endocrinol, [620.0, 1351.0, 1115.0, 1445.0] reference_item 0.85 ["reference content label: [5] E. Mackie, L. Tatarzuch, and M. Mirams, \"The skeleton: a"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
132 10 13 footer Universidad Distrital Francisco José de Caldas - Facultad tecnológica [594.0, 1478.0, 1115.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 tail_nonref_hold_zone unknown_like none False False
133 11 0 header The effect of frequency in the electrical stimulation of chondrocytes [109.0, 97.0, 640.0, 113.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
134 11 1 number 16 [1092.0, 101.0, 1113.0, 115.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
135 11 2 reference_content vol. 211, no. 2, pp. 109-121, 2011. https://doi.org/10.1530/JOE-11-0048 [139.0, 146.0, 602.0, 192.0] reference_item 0.85 ["reference content label: vol. 211, no. 2, pp. 109-121, 2011. https://doi.org/10.1530/"] reference_item 0.85 reference_zone unknown_like none True True
136 11 3 reference_content [6] C. Lee, S. Grad, M. Wimmer, and M. Alini, “The influence of mechanical stimuli on articular cartilage tissue engineering”, in Topics in Tissue Engineering, vol. 2, Davos Platz, Switzerland: Ashamm [112.0, 211.0, 604.0, 331.0] reference_item 0.85 ["reference content label: [6] C. Lee, S. Grad, M. Wimmer, and M. Alini, \u201cThe influence"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
137 11 4 reference_content [7] Z. Lukacs, “Mucopolysaccharides”, in Laboratory Guide to the Methods in Biochemical Genetics, 1st ed., N. Blau., Ed. Heidelberg: Springer, 2008, pp. 287-325. https://doi.org/10.1007/978-3-540-7669 [112.0, 351.0, 605.0, 469.0] reference_item 0.85 ["reference content label: [7] Z. Lukacs, \u201cMucopolysaccharides\u201d, in Laboratory Guide to"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
138 11 5 reference_content [8] J. S. Temenoff and A. G. Mikos, “Review: Tissue engineering for regeneration of articular cartilage”, Biomaterials, vol. 21, no. 5, pp. 431-440, 2000. https://doi.org/10.1016/S0142-9612(99)00213-6 [112.0, 490.0, 603.0, 586.0] reference_item 0.85 ["reference content label: [8] J. S. Temenoff and A. G. Mikos, \u201cReview: Tissue engineer"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
139 11 6 reference_content [9] P. Armstrong, C. Brighton, and A. Star, "Capacitively coupled electrical stimulation of bovine growth plate chondrocytes grown in pellet form", J Orthop Res, vol. 6, no. 2, pp. 265-271, 1988. http [112.0, 606.0, 605.0, 725.0] reference_item 0.85 ["reference content label: [9] P. Armstrong, C. Brighton, and A. Star, \"Capacitively co"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
140 11 7 reference_content [10] C. T. Brighton, L. Jensen, S. R. Pollack, B. S. Tolin, and C. C. Clark, “Proliferative and synthetic response of bovine growth plate chondrocytes to various capacitively coupled electrical fields [112.0, 746.0, 604.0, 888.0] reference_item 0.85 ["reference content label: [10] C. T. Brighton, L. Jensen, S. R. Pollack, B. S. Tolin, "] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
141 11 8 reference_content [11] C. Brighton, G. Pfeffer, and S. Pollack, “In vivo growth plate stimulation in various capacitively coupled electrical fields”, J. Orthop. Res., vol. 1, no. 1, pp. 42-49, 1983. https://doi.org/10. [113.0, 908.0, 603.0, 1026.0] reference_item 0.85 ["reference content label: [11] C. Brighton, G. Pfeffer, and S. Pollack, \u201cIn vivo growt"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
142 11 9 reference_content [12] C. Brighton and P. Townsend, “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes”, J Orthop Res, vol. 6, no. 4, pp. 552-558, 1988. htt [113.0, 1049.0, 606.0, 1166.0] reference_item 0.85 ["reference content label: [12] C. Brighton and P. Townsend, \u201cIncreased cAMP production"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
143 11 10 reference_content [13] C. Brighton, A. Unger, and J. Stambough, “In vitro growth of bovine articular cartilage chondrocytes in various capacitively coupled electrical fields”, J Orthop Res, vol. 2, no. 1, pp. 15-22, 19 [112.0, 1188.0, 606.0, 1306.0] reference_item 0.85 ["reference content label: [13] C. Brighton, A. Unger, and J. Stambough, \u201cIn vitro grow"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
144 11 11 reference_content [14] C. Brighton, W. Wang, and C. Clark, "Up-regulation of matrix in bovine articular cartilage explants by electric fields", Biochem Biophys Res Commun, vol. 342, no. 2, pp. 556-561, 2006. https://do [112.0, 1327.0, 605.0, 1445.0] reference_item 0.85 ["reference content label: [14] C. Brighton, W. Wang, and C. Clark, \"Up-regulation of m"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
145 11 12 reference_content [15] C. Brighton, W. Wang, and C. Clark, “The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants”, J Bone Jt. Surg Am, vol. 90, no. 4, pp. 833-848, 2 [622.0, 145.0, 1114.0, 262.0] reference_item 0.85 ["reference content label: [15] C. Brighton, W. Wang, and C. Clark, \u201cThe effect of elec"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
146 11 13 reference_content [16] C. T. Brighton, G. B. Pfeffer, and S. R. Pollack, “In vivo growth plate stimulation in various capacitively coupled electrical fields”, J. Orthop. Res., vol. 1, no. 1, pp. 42-49, 1983. https://do [621.0, 287.0, 1114.0, 403.0] reference_item 0.85 ["reference content label: [16] C. T. Brighton, G. B. Pfeffer, and S. R. Pollack, \u201cIn v"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
147 11 14 reference_content [17] M. Forgon, V. Vámhidy, and L. Kellényi, “Bone growth accelerated by stimulation of the epiphyseal plate with electric current”, Arch. Orthop. Trauma. Surg., vol. 104, no. 2, pp. 121-124, 1985. ht [621.0, 428.0, 1114.0, 546.0] reference_item 0.85 ["reference content label: [17] M. Forgon, V. V\u00e1mhidy, and L. Kell\u00e9nyi, \u201cBone growth ac"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
148 11 15 reference_content [18] S. Nakasuji, Y. Morita, and K. Anaka, “Effect of Pulse Electric Field Stimulation on Chondrocytes”, Asian Pacific Conf. Mater. Mech., vol. 1, pp. 13-16, 2009. [621.0, 569.0, 1115.0, 664.0] reference_item 0.85 ["reference content label: [18] S. Nakasuji, Y. Morita, and K. Anaka, \u201cEffect of Pulse "] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
149 11 16 reference_content [19] O. Sato and M. Akai, “Effect of direct-current stimulation on the growth plate”, Arch Orthop Trauma Surg, vol. 109, pp. 9-13, 1989. https://doi.org/10.1007/BF00441903 [621.0, 687.0, 1115.0, 783.0] reference_item 0.85 ["reference content label: [19] O. Sato and M. Akai, \u201cEffect of direct-current stimulat"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
150 11 17 reference_content [20] N. Szasz, H. Hung, S. Sen, and A. Grodzinsky, “Electric field regulation of chondrocyte biosynthesis in agarose gel constructs”, in 49th Annual Meeting of the Orthopaedic Research Society, 2003. [621.0, 805.0, 1114.0, 901.0] reference_item 0.85 ["reference content label: [20] N. Szasz, H. Hung, S. Sen, and A. Grodzinsky, \u201cElectric"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
151 11 18 reference_content [21] J. J. Vaca-González, J. Escobar, J. Guevara, Y. Hata, G. Gallego Ferrer, and D. A. Garzón-Alvarado, "Capacitively coupled electrical stimulation of rat chondroepiphysis explants: A histomorphomet [622.0, 924.0, 1114.0, 1089.0] reference_item 0.85 ["reference content label: [21] J. J. Vaca-Gonz\u00e1lez, J. Escobar, J. Guevara, Y. Hata, G"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
152 11 19 reference_content [22] J. J. Vaca-González, J. Guevara, J. Vega, and D. A. Garzón-Alvarado, "An in vitro chondrocyte electrical stimulation framework: a methodology to calculate electric fields and modulate proliferati [621.0, 1114.0, 1115.0, 1280.0] reference_item 0.85 ["reference content label: [22] J. J. Vaca-Gonz\u00e1lez, J. Guevara, J. Vega, and D. A. Gar"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
153 11 20 reference_content [23] W. Wang, Z. Wang, G. Zhang, C. C. Clark, and C. T. Brighton, "Up-regulation of chondrocyte matrix genes and products by electric fields", Clin. Orthop. Relat. Res., no. 427 SUPPL., pp. 163-173, 2 [622.0, 1304.0, 1115.0, 1442.0] reference_item 0.85 ["reference content label: [23] W. Wang, Z. Wang, G. Zhang, C. C. Clark, and C. T. Brig"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
154 11 21 footer Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia) [110.0, 1478.0, 1039.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False
155 12 0 number 17 [111.0, 100.0, 133.0, 115.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
156 12 1 header J. J. VACA-GONZÁLEZ, J. F. ESCOBAR-HUERTAS AND D. A. GARZÓN-ALVARADO [591.0, 96.0, 1115.0, 113.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
157 12 2 reference_content [24] C. Grosse and H. Schwan, “Cellular membrane potentials induced by alternating fields”, Biophys. J., vol. 63, no. 6, pp. 1632-1642, Dec. 1992. https://doi.org/10.1016/S0006-3495(92)81740-X [112.0, 145.0, 604.0, 239.0] reference_item 0.85 ["reference content label: [24] C. Grosse and H. Schwan, \u201cCellular membrane potentials "] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
158 12 3 reference_content [25] T. Kotnik, F. Bobanović, and D. Miklavcic, “Sensitivity of transmembrane voltage induced by applied electric fields-A theoretical analysis”, Bioelectrochemistry Bioenerg., vol. 43, no. 2, pp. 285 [112.0, 254.0, 604.0, 396.0] reference_item 0.85 ["reference content label: [25] T. Kotnik, F. Bobanovi\u0107, and D. Miklavcic, \u201cSensitivity"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
159 12 4 reference_content [26] W. Krassowska and J. C. Neu, “Response of a single cell to an external electric field”, Biophys. J., vol. 66, no. 6, pp. 1768-1776, 1994. https://doi.org/10.1016/S0006-3495(94)80971-3 [114.0, 412.0, 605.0, 507.0] reference_item 0.85 ["reference content label: [26] W. Krassowska and J. C. Neu, \u201cResponse of a single cell"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
160 12 5 reference_content [27] B. Valič et al., “Effect of electric field induced transmembrane potential on spheroidal cells: theory and experiment”, Eur. Biophys. J., vol. 32, no. 6, pp. 519-528, 2003. https://doi.org/10.100 [113.0, 522.0, 604.0, 641.0] reference_item 0.85 ["reference content label: [27] B. Vali\u010d et al., \u201cEffect of electric field induced tran"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
161 12 6 reference_content [28] K. Maswiwat, D. Wachner, and J. Gimsa, “Effects of cell orientation and electric field frequency on the transmembrane potential induced in ellipsoidal cells”, Bioelectrochemistry, vol. 74, no. 1, [112.0, 657.0, 603.0, 800.0] reference_item 0.85 ["reference content label: [28] K. Maswiwat, D. Wachner, and J. Gimsa, \u201cEffects of cell"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
162 12 7 reference_content [29] J. Gimsa and D. Wachner, “Analytical description of the transmembrane voltage induced on arbitrarily oriented ellipsoidal and cylindrical cells”, Biophys. J., vol. 81, no. 4, pp. 1888-1896, Oct. [112.0, 815.0, 603.0, 934.0] reference_item 0.85 ["reference content label: [29] J. Gimsa and D. Wachner, \u201cAnalytical description of the"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
163 12 8 reference_content [30] T. Taghian, D. A. Narmoneva, and A. B. Kogan, "Modulation of cell function by electric field : a high-resolution analysis", R. Soc., vol. 12, no. 107, pp. 21-25, 2015. https://doi.org/10.1098/rsi [112.0, 948.0, 603.0, 1066.0] reference_item 0.85 ["reference content label: [30] T. Taghian, D. A. Narmoneva, and A. B. Kogan, \"Modulati"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
164 12 9 reference_content [31] J. J. Vaca-González, “The effect of electric fields on hyaline cartilage: an in vitro and in silico study”, Universidad Nacional de Colombia, 2019. [113.0, 1082.0, 604.0, 1154.0] reference_item 0.85 ["reference content label: [31] J. J. Vaca-Gonz\u00e1lez, \u201cThe effect of electric fields on "] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
165 12 10 reference_content [32] J. J. Vaca-González et al., “Effect of electrical stimulation on chondrogenic differentiation of mesenchymal stem cells cultured in hyaluronic acid - Gelatin injectable hydrogels”, Bioelectrochem [113.0, 1170.0, 605.0, 1311.0] reference_item 0.85 ["reference content label: [32] J. J. Vaca-Gonz\u00e1lez et al., \u201cEffect of electrical stimu"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
166 12 11 reference_content [33] M. A. Golombeck, H. C. Riedel, and O. Dössel, "Calculation of the dielectric properties of biological tissue using simple models of cell patches", Biomed. Tech. Eng., vol. 47, pp. 253-256, 2002. [113.0, 1327.0, 604.0, 1444.0] reference_item 0.85 ["reference content label: [33] M. A. Golombeck, H. C. Riedel, and O. D\u00f6ssel, \"Calculat"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
167 12 12 reference_content [34] C. Gabriel, “Compilation of the Dielectric Properties of Body Tissues at RF and Microwave Frequencies.”, London, UK, 1996. https://doi.org/10.21236/ADA303903 [622.0, 145.0, 1113.0, 238.0] reference_item 0.85 ["reference content label: [34] C. Gabriel, \u201cCompilation of the Dielectric Properties o"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
168 12 13 reference_content [35] J. F. Escobar, “Evaluación in vitro del efecto de una estimulación con campos magnéticos a condrocitos”, Universidad Nacional de Colombia, 2019. [622.0, 258.0, 1113.0, 328.0] reference_item 0.85 ["reference content label: [35] J. F. Escobar, \u201cEvaluaci\u00f3n in vitro del efecto de una e"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
169 12 14 reference_content [36] C. Trainito, “Study of cell membrane permeabilization induced by pulsed electric field - electrical modeling and characterization on biochip”, Université Paris-Saclay, 2016. [621.0, 345.0, 1113.0, 440.0] reference_item 0.85 ["reference content label: [36] C. Trainito, \u201cStudy of cell membrane permeabilization i"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
170 12 15 reference_content [37] C. Litalien and P. Beaulieu, “Molecular Mechanisms of Drug Actions: From Receptors to Effectors”, in Pediatric Critical Care, B. P. Fuhrman and J. J. B. T.-P. C. C. (Fourth E. Zimmerman, Eds. Sai [621.0, 459.0, 1113.0, 600.0] reference_item 0.85 ["reference content label: [37] C. Litalien and P. Beaulieu, \u201cMolecular Mechanisms of D"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
171 12 16 reference_content [38] C. Matta, R. Zákány, and A. Mobasheri, "Voltage-dependent calcium channels in chondrocytes: roles in health and disease", Curr. Rheumatol. Rep., vol. 17, no. 43, pp. 1-11, 2015. https://doi.org/1 [621.0, 619.0, 1114.0, 739.0] reference_item 0.85 ["reference content label: [38] C. Matta, R. Z\u00e1k\u00e1ny, and A. Mobasheri, \"Voltage-depende"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
172 12 17 reference_content [39] J. Xu, W. Wang, C. Clark, and C. Brighton, “Signal transduction in electrically stimulated articular chondrocytes involves translocation of extracellular calcium through voltage-gated channels”, [621.0, 757.0, 1114.0, 899.0] reference_item 0.85 ["reference content label: [39] J. Xu, W. Wang, C. Clark, and C. Brighton, \u201cSignal tran"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
173 12 18 reference_content [40] W. A. Catterall, “Voltage-gated calcium channels”, Cold Spring Harb. Perspect. Biol., vol. 3, no. 8, pp. 1-23, Aug. 2011. https://doi.org/10.1101/cshperspect.a003947 [621.0, 916.0, 1114.0, 1012.0] reference_item 0.85 ["reference content label: [40] W. A. Catterall, \u201cVoltage-gated calcium channels\u201d, Cold"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
174 12 19 reference_content [41] T. Ning, K. Zhang, B. C. Heng, and Z. Ge, “Diverse effects of pulsed electrical stimulation on cells - with a focus on chondrocytes and cartilage regeneration”, Cells Mater., vol. 38, pp. 79-83, [621.0, 1030.0, 1113.0, 1148.0] reference_item 0.85 ["reference content label: [41] T. Ning, K. Zhang, B. C. Heng, and Z. Ge, \u201cDiverse effe"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
175 12 20 reference_content [42] J. F. Escobar, J. J. Vaca-González, J. M. Guevara, and D. A. Garzón-Alvarado, “Effect of magnetic and electric fields on plasma membrane of single cells: A computational approach”, Eng. Reports, [621.0, 1167.0, 1114.0, 1308.0] reference_item 0.85 ["reference content label: [42] J. F. Escobar, J. J. Vaca-Gonz\u00e1lez, J. M. Guevara, and "] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
176 12 21 reference_content [43] A. Weizel et al., “Numerical simulation of the electric field distribution in an electrical stimulation device for scaffolds settled with cartilaginous cells”, in 2019 41st Annual International C [621.0, 1328.0, 1115.0, 1446.0] reference_item 0.85 ["reference content label: [43] A. Weizel et al., \u201cNumerical simulation of the electric"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
177 12 22 footer Universidad Distrital Francisco José de Caldas - Facultad tecnológica [594.0, 1478.0, 1115.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False
178 13 0 header The effect of frequency in the electrical stimulation of chondrocytes [109.0, 97.0, 640.0, 113.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
179 13 1 number 18 [1092.0, 101.0, 1113.0, 114.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
180 13 2 reference_content (EMBC), 2019, pp. 6481-6484. https://doi.org/10.1109/EMBC.2019.8857760 [141.0, 145.0, 604.0, 190.0] reference_item 0.85 ["reference content label: (EMBC), 2019, pp. 6481-6484. https://doi.org/10.1109/EMBC.20"] reference_item 0.85 reference_zone unknown_like none True True
181 13 3 reference_content [44] B. Hiemer et al., “Effect of electric stimulation on human chondrocytes and mesenchymal stem cells under normoxia and hypoxia”, Mol. Med. Rep., vol. 18, no. 2, pp. 2133-2141, Aug. 2018. https://d [113.0, 205.0, 604.0, 321.0] reference_item 0.85 ["reference content label: [44] B. Hiemer et al., \u201cEffect of electric stimulation on hu"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
182 13 4 reference_content [45] O. Akanji, D. Lee, and D. Bader, “The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs”, Biorheology, vol. 45, no. 3-4, pp. 229-243, 2008. https://do [622.0, 146.0, 1115.0, 260.0] reference_item 0.85 ["reference content label: [45] O. Akanji, D. Lee, and D. Bader, \u201cThe effects of direct"] reference_item 0.85 reference_zone reference_like reference_numeric_bracket True True
183 13 5 footer Visión Electrónica Vol. 14 No. 1 (2020) • January • p.p. 6-18 • ISSN 1909-9746 • ISSN-E 2248-4728 • Bogotá (Colombia) [110.0, 1478.0, 1040.0, 1498.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False

97
audit/24YKLTHQ/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,97 @@
{
"figures": {
"matched_count": 6,
"ambiguous_count": 0,
"unresolved_cluster_count": 1,
"unmatched_asset_count": 6,
"matched": [
{
"figure_number": 1,
"legend_block_id": 7,
"asset_block_ids": [
8
],
"page": 3,
"match_type": null
},
{
"figure_number": 2,
"legend_block_id": 3,
"asset_block_ids": [
4
],
"page": 5,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 9,
"asset_block_ids": [
10
],
"page": 5,
"match_type": null
},
{
"figure_number": 4,
"legend_block_id": 6,
"asset_block_ids": [
7,
8
],
"page": 6,
"match_type": null
},
{
"figure_number": 5,
"legend_block_id": 2,
"asset_block_ids": [
3,
4
],
"page": 7,
"match_type": null
},
{
"figure_number": 6,
"legend_block_id": 5,
"asset_block_ids": [
6
],
"page": 8,
"match_type": null
}
],
"ambiguous": [],
"unresolved": [
{
"figure_number": null,
"asset_block_ids": [],
"page": 6
}
]
},
"tables": {
"matched_count": 1,
"ambiguous_count": 1,
"unmatched_asset_count": 10,
"matched": [
{
"table_number": 2,
"caption_block_id": 5,
"asset_block_ids": [],
"page": 4,
"match_status": "matched"
}
],
"ambiguous": [
{
"table_number": 1,
"caption_block_id": 2,
"asset_block_ids": [],
"page": 4,
"match_status": "ambiguous"
}
]
}
}

1517
audit/24YKLTHQ/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

297
audit/24YKLTHQ/page_risk_summary.json Normal file
View file

@ -0,0 +1,297 @@
{
"pages": [
{
"page": 1,
"risk_score": 14,
"risk_reasons": [
"frontmatter_page",
"multi_asset_page",
"reader_object_gap",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"frontmatter",
"object_ownership"
],
"counts": {
"body_paragraph": 5,
"reference_item": 0,
"tail_like": 0,
"media_assets": 2,
"table_like": 0,
"captions": 0,
"hold": 1,
"unknown_structural": 3,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 5,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 3,
"risk_score": 6,
"risk_reasons": [
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 4,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 4,
"captions": 4,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 5,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 5,
"reference_item": 0,
"tail_like": 0,
"media_assets": 2,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 4,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 7,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 8,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 8,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 9,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 10,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 4,
"reference_item": 5,
"tail_like": 4,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 11,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 19,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 12,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 20,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 13,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 3,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
3,
4,
5,
6,
7,
8,
10
]
}

403
audit/24YKLTHQ/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,403 @@
{
"candidates": [
{
"block_id": "p10:7",
"page": 10,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:8",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:9",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:10",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:11",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:12",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:13",
"page": 10,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:0",
"page": 11,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:1",
"page": 11,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:2",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:3",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:4",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:5",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:6",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:7",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:8",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:9",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:10",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:11",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:12",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:13",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:14",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:15",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:16",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:17",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:18",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:19",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:20",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:21",
"page": 11,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:0",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:1",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:2",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:3",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:4",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:5",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:6",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:7",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:8",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:9",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:10",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:11",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:12",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:13",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:14",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:15",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:16",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:17",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:18",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:19",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:20",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:21",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:22",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:0",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:1",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:2",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:3",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:4",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

524
audit/24YKLTHQ/reference_span_audit.json Normal file
View file

@ -0,0 +1,524 @@
{
"reference_span": {
"status": "ACCEPT",
"span_id": "refspan_001",
"start": {
"page": 10,
"column": 2,
"y": 728.0,
"block_id": "p10:7"
},
"end": {
"page": 13,
"column": 2,
"y": 146.0,
"block_id": "p13:4"
},
"heading_block_id": "p10:7",
"ordered_block_ids": [
"p10:7",
"p10:8",
"p10:9",
"p10:10",
"p10:11",
"p10:12",
"p11:2",
"p11:3",
"p11:4",
"p11:5",
"p11:6",
"p11:7",
"p11:8",
"p11:9",
"p11:10",
"p11:11",
"p11:12",
"p11:13",
"p11:14",
"p11:15",
"p11:16",
"p11:17",
"p11:18",
"p11:19",
"p11:20",
"p12:2",
"p12:3",
"p12:4",
"p12:5",
"p12:6",
"p12:7",
"p12:8",
"p12:9",
"p12:10",
"p12:11",
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p12:16",
"p12:17",
"p12:18",
"p12:19",
"p12:20",
"p12:21",
"p13:2",
"p13:3",
"p13:4"
],
"inside_block_ids": [
"p10:7",
"p10:8",
"p10:9",
"p10:10",
"p10:11",
"p10:12",
"p11:2",
"p11:3",
"p11:4",
"p11:5",
"p11:6",
"p11:7",
"p11:8",
"p11:9",
"p11:10",
"p11:11",
"p11:12",
"p11:13",
"p11:14",
"p11:15",
"p11:16",
"p11:17",
"p11:18",
"p11:19",
"p11:20",
"p12:2",
"p12:3",
"p12:4",
"p12:5",
"p12:6",
"p12:7",
"p12:8",
"p12:9",
"p12:10",
"p12:11",
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p12:16",
"p12:17",
"p12:18",
"p12:19",
"p12:20",
"p12:21",
"p13:2",
"p13:3",
"p13:4"
],
"explicitly_outside_nearby_block_ids": [
"p10:6",
"p13:5"
],
"intrusion_candidates": [
{
"block_id": "p10:7",
"page": 10,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:8",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:9",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:10",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:11",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:12",
"page": 10,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p10:13",
"page": 10,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:0",
"page": 11,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:1",
"page": 11,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:2",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:3",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:4",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:5",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:6",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:7",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:8",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:9",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:10",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:11",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:12",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:13",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:14",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:15",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:16",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:17",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:18",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:19",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:20",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:21",
"page": 11,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:0",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:1",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:2",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:3",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:4",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:5",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:6",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:7",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:8",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:9",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:10",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:11",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:12",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:13",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:14",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:15",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:16",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:17",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:18",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:19",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:20",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:21",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:22",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:0",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:1",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:2",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:3",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:4",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}
}

517
audit/27MSS3VH/audit_report.json Normal file
View file

@ -0,0 +1,517 @@
{
"paper_key": "27MSS3VH",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:d28308199b15dc306796f0a5c68f4f9b36f8411ffc37486c1c0fc9c994208155",
"meta_json_hash": "sha256:7bcf6bb36a5d80834eee07b6e53d5a7a0a6b1ec0466b15503b6a6922cca43b2b",
"blocks_raw_hash": "sha256:f8438964c274440b439941b488a52c0f51afdbfb6bb5757e387cba20acc6aa67",
"structured_blocks_hash": "sha256:d42b5092dba7e6d37cc22acbd197fed4d2a69c046dc2e8bd28c143ffc5dbbab9",
"document_structure_hash": "sha256:fbd59b4d0e70b24de5bf5d89728895203eefddc78695843d49bee1b639321d28",
"figure_inventory_hash": "sha256:336ef2329541f6b8fc11b415a5c544871b0363b036bdb771eac2f8b6d5b437b4",
"table_inventory_hash": "sha256:01a8da0a5b81cc044cffce3758fa08e9cc774d950a4454412b4798bfe97591c4",
"reader_figures_hash": "sha256:4bd8d60fe2d4bebadef4baa811206f566d81c09e9a66ccab5f9b3fb567eaf61f",
"resolved_metadata_hash": "sha256:a8879275087584d1d148e3c7b20b9a88bfbe5c8278f1eaf2ce6516817058d7e6",
"fulltext_hash": "sha256:f0d4a0f221ff70642f15dc5f3167f60cb2a3e57936054b1601fe8fe194d925d3",
"block_trace_hash": "sha256:0a2717591ba259802103c7ff7fd56d8e46725324330e0f3d79d65da0f6f5281f",
"annotated_pages": {
"page_001.png": "sha256:28f7f5539d3388bcd5a8907f350c0b37104624cae251795b1595505f20f979a0",
"page_002.png": "sha256:cc0d454543312f21b3528cec04257914ae50b2377ae9c53fce46ad5329233ac6",
"page_003.png": "sha256:db46b8782cf1aee19ac1ddd710a69e8fa8328b4b77c0d777be6081539e10e279",
"page_004.png": "sha256:400421b630c52f54daab84597c7b826d3b9eccad88c03468e3e5038e3c6a95de",
"page_005.png": "sha256:203d121ec8bc98be9ee7f2ee393de2c9920895f0fd6c5a2eafe9a2f8c84e8139",
"page_006.png": "sha256:051a18b2f7a426a196ecad62a40de70c964773892f3077298b0ce0b53d8e456a",
"page_007.png": "sha256:743827b674468ba8c560a5efcc6decf61b4d3127a077bf9726af47db19017671",
"page_008.png": "sha256:60936efa8565a97a2031315e0b441762b7bec9525490104dbc3f562808c87a6b",
"page_009.png": "sha256:f78784333211776fb01880c06eaf323e94fa42fd9c58f5b2cf5ed0e060fc4f51",
"page_010.png": "sha256:885d0d35a1e3da81956c2d81d82f479ceb3831dede384a3c34f3c4307f60c29d",
"page_011.png": "sha256:9684e430dff2e6c0bb560f817d481c6435de5b28210ce9cf5dca58c2bd8b0877",
"page_012.png": "sha256:3eac6016f50f315bfd7723ba2678d558730589f7bedc6bcf413c2de1ee9a9a04",
"page_013.png": "sha256:1bb3b6ab222325f5ffd9eb0fd13fbd9d25e7a1fb453b64de7db223648cb586a4",
"page_014.png": "sha256:67cb5d6d37d83592618b60a9d77e1a9c62402aa9bc2fc0b416929344ee2c62aa"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png",
"page_008.png",
"page_009.png",
"page_010.png",
"page_011.png",
"page_012.png",
"page_013.png",
"page_014.png"
]
},
"reviewed_pages": [
1,
3,
4,
5,
6,
8,
10,
11
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p3:0",
"p3:1",
"p3:2",
"p3:3",
"p3:4",
"p3:5",
"p3:6",
"p3:7",
"p3:8",
"p3:9",
"p3:10",
"p3:11",
"p4:0",
"p4:1",
"p4:2",
"p4:3",
"p4:4",
"p4:5",
"p4:6",
"p5:0",
"p5:1",
"p5:2",
"p5:3",
"p5:4",
"p5:5",
"p5:6",
"p5:7",
"p5:8",
"p5:9",
"p6:0",
"p6:1",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p8:0",
"p8:1",
"p8:2",
"p8:3",
"p8:4",
"p8:5",
"p8:6",
"p8:7",
"p8:8",
"p8:9",
"p8:10",
"p8:11",
"p8:12",
"p8:13",
"p10:0",
"p10:1",
"p10:2",
"p10:3",
"p10:4",
"p10:5",
"p10:6",
"p10:7",
"p10:8",
"p10:9",
"p10:10",
"p10:11",
"p11:0",
"p11:1",
"p11:2",
"p11:3",
"p11:4",
"p11:5",
"p11:6",
"p11:7",
"p11:8",
"p11:9",
"p11:10",
"p11:11",
"p11:12",
"p11:13",
"p11:14",
"p11:15",
"p11:16",
"p11:17",
"p11:18",
"p11:19",
"p11:20",
"p11:21",
"p11:22",
"p11:23",
"p11:24",
"p11:25",
"p11:26",
"p11:27",
"p11:28",
"p11:29",
"p11:30",
"p11:31",
"p11:32",
"p11:33",
"p11:34",
"p11:35"
],
"findings": [
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:17"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:18"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:19"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:20"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:21"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:22"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:23"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:24"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:25"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:26"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:27"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:28"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:29"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:30"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:31"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:32"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:33"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:34"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p11:35"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:0",
"p1:4",
"p1:12",
"p1:14",
"p1:15",
"p2:1",
"p2:2",
"p2:3",
"p2:9",
"p2:13",
"p3:0",
"p3:2",
"p3:10",
"p3:11",
"p4:1",
"p4:2",
"p4:5",
"p4:6",
"p5:0",
"p5:2"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

37
audit/27MSS3VH/audit_report.md Normal file
View file

@ -0,0 +1,37 @@
# OCR Truth Audit Report - 27MSS3VH
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 3, 4, 5, 6, 8, 10, 11]
- Reviewed blocks: 118
## Findings
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

748
audit/27MSS3VH/audit_scope.json Normal file
View file

@ -0,0 +1,748 @@
{
"mode": "high-risk",
"selected_pages": [
1,
3,
4,
5,
6,
8,
10,
11
],
"required_block_ids": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p3:3",
"p4:3",
"p5:3",
"p6:6",
"p8:2",
"p10:1",
"p10:9",
"p11:17",
"p11:18",
"p11:19",
"p11:20",
"p11:21",
"p11:22",
"p11:23",
"p11:24",
"p11:25",
"p11:26",
"p11:27",
"p11:28",
"p11:29",
"p11:30",
"p11:31",
"p11:32",
"p11:33",
"p11:34",
"p11:35"
],
"required_blocks": [
{
"block_id": "p1:0",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:1",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:2",
"page": 1,
"required_reason": [
"frontmatter",
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:3",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:4",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:5",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:6",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:7",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:8",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:9",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:10",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:11",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:12",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:13",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:14",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:15",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:16",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p3:3",
"page": 3,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:3",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:3",
"page": 5,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p6:6",
"page": 6,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p8:2",
"page": 8,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:1",
"page": 10,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:9",
"page": 10,
"required_reason": [
"same_page_boundary"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:17",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:18",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:19",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:20",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:21",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:22",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:23",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:24",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:25",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:26",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:27",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:28",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:29",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:30",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:31",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:32",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:33",
"page": 11,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:34",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:35",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
}
],
"selected_page_requirements": [
{
"page": 1,
"must_review_page": true,
"required_block_count": 17
},
{
"page": 3,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 4,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 5,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 6,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 8,
"must_review_page": true,
"required_block_count": 1
},
{
"page": 10,
"must_review_page": true,
"required_block_count": 2
},
{
"page": 11,
"must_review_page": true,
"required_block_count": 19
}
]
}

5378
audit/27MSS3VH/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

304
audit/27MSS3VH/block_trace.csv Normal file
View file

@ -0,0 +1,304 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,header,THEMED ARTICLE | Nanotechnology & Single-Cell Analysis,"[138.0, 93.0, 796.0, 125.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,1,header,Review,"[1030.0, 92.0, 1128.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False
1,2,header_image,,"[140.0, 220.0, 318.0, 303.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True
1,3,doc_title,Contributions and future perspectives on the use of magnetic nanoparticles as diagnostic and therapeutic tools in the field of regenerative medicine,"[373.0, 215.0, 1019.0, 595.0]",paper_title,0.8,"[""page-1 zone title_zone: Contributions and future perspectives on the use of magnetic""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True
1,4,text,"Expert Rev. Mol. Diagn. 13(6), 553–566 (2013)","[375.0, 633.0, 726.0, 657.0]",structured_insert_candidate,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,False,False
1,5,text,"Vítor E Santo $ ^{1,2} $, Márcia T Rodrigues $ ^{1,2} $ and Manuela E Gomes $ ^{*1,2} $","[115.0, 692.0, 353.0, 771.0]",frontmatter_noise,0.7,"[""keyword-like block: V\u00edtor E Santo $ ^{1,2} $, M\u00e1rcia T Rodrigues $ ^{1,2} $ and ""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,6,text,"³B's Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806–909 Caldas das Taipas, Guimarães, Portugal
²ICV","[115.0, 780.0, 352.0, 962.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00b3B's Research Group \u2013 Biomaterials, Biodegradables and Biomi""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,7,abstract,"The current limitations of regenerative medicine strategies may be overcome through the use of magnetic nanoparticles (MNPs), a class of nanomaterial typically composed of magnetic elements that can b","[373.0, 691.0, 1144.0, 971.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,8,text,KEYWORDS: magnetic particles • magnetic responsive systems • regenerative medicine • stem cells • theranostics • tissue engineering,"[379.0, 987.0, 1121.0, 1028.0]",frontmatter_noise,0.7,"[""frontmatter noise text: KEYWORDS: magnetic particles \u2022 magnetic responsive systems \u2022""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,9,text,The goal of producing functional tissue substitutes using tissue engineering or other regenerative medicine strategies is challenged by the complexity of organ architectures $ [1] $. Some of the most,"[374.0, 1040.0, 753.0, 1449.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,10,text,Nanoparticle research within regenerative medicine has been mainly focused on the development of delivery systems for biomolecules and reinforcing phase for polymeric matrices in 3D scaffolds for tiss,"[375.0, 1449.0, 753.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,11,text,"development of delivery systems for biomol-
ecules and reinforcing phase for polymeric
matrices in 3D scaffolds for tissue engineering
[4]. For instance, hydroxyapatite nanocrystals
have been used in ","[765.0, 1040.0, 1145.0, 1500.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,12,footer,www.expert-reviews.com,"[115.0, 1532.0, 329.0, 1551.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
1,13,footer,10.1586/14737159.2013.819169,"[377.0, 1532.0, 584.0, 1551.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
1,14,footer,© 2013 Informa UK Ltd,"[693.0, 1532.0, 857.0, 1551.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
1,15,footer,ISSN 1473-7159,"[924.0, 1532.0, 1023.0, 1550.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
1,16,number,553,"[1104.0, 1529.0, 1143.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
2,0,header,Review,"[87.0, 93.0, 184.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False
2,1,header,"Santo, Rodrigues & Gomes","[206.0, 97.0, 459.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False
2,2,text,"most promising inorganic nanomaterials being developed are metal, silica, dendrimers, ceramics and bioinorganic hybrids. Metallic nanoparticle contrast agents are typically applied for in vivo imaging","[67.0, 176.0, 576.0, 297.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,3,text,Magnetic nanoparticles (MNPs) have shown high potential for different biomedical applications as they present the ability to be manipulated under the influence of an external magnetic field [7]. The m,"[67.0, 297.0, 576.0, 656.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,4,text,The ability of MNPs to be functionalized and concurrently respond to a magnetic field has made them a useful tool for theranostics [7]. MNPs can be coated/functionalized with organic or inorganic mate,"[67.0, 656.0, 577.0, 1209.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,5,text,The association of MNPs with stem cells can be achieved by internalization of MNPs or through binding of these particles to cell surface markers such as integrins or through direct interaction with sp,"[67.0, 1208.0, 576.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,6,text,"for the design of multifunctional theranostic nanoparticles is the
simultaneous incorporation of diagnostic elements and therapeutic
motifs, specifically drug delivery ability [20].
d h ll h b d","[589.0, 175.0, 1098.0, 248.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,7,text,"Once associated with cells, the MNPs can be incorporated into a 3D scaffold or hydrogel to obtain a tissue-engineered magnetic responsive system, enabling all the above mentioned functionalities. Alte","[588.0, 248.0, 1099.0, 612.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,8,paragraph_title,3D magnetic constructs as the basis for a new generation of tissue-engineered substitutes,"[590.0, 632.0, 1012.0, 679.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: 3D magnetic constructs as the basis for a new generation of ""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,True,True
2,9,text,"It is well known that the mechanical environment to which native tissues and cells are exposed significantly influences the homeostasis and regeneration processes. Therefore, techniques that directly ","[589.0, 680.0, 1099.0, 1161.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: It is well known that the mechanical environment to which na""]",affiliation,0.8,body_zone,body_like,none,True,True
2,10,text,The labeling of stem cells with MNPs has been increasingly used to enable cell tracking and magnetic manipulation. The ability to noninvasively monitor cell trafficking in vivo in a longitudinal fashi,"[588.0, 1160.0, 1099.0, 1376.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,11,text,"The impact of magnetic stimulation on stem cell differentiation is still controversial [25]. Mechanical forces contribute to several cellular functions, including changes in gene expression, prolifera","[588.0, 1376.0, 1099.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,12,number,554,"[71.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
2,13,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1532.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
3,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403.0, 99.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
3,1,header,Review,"[1031.0, 94.0, 1127.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,2,text,"regulation, converting mechanical stimulus into biochemical signals [27]. The internalization of MNPs and consequent magnetic stimulation might be used to induce specific biomechanical signals and thu","[114.0, 177.0, 451.0, 850.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,3,image,,"[471.0, 179.0, 1137.0, 556.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
3,4,figure_title,Figure 1. Potential strategies that can be used to augment the complexity and functionality of magnetic nanoparticles. The particles can be functionalized with antibodies for cell targeting and select,"[473.0, 573.0, 1136.0, 816.0]",figure_caption,0.92,"[""figure_title label: Figure 1. Potential strategies that can be used to augment t""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
3,5,text,late the delivery of bioactive agents with an external stimulus can potentially improve the safety and efficiency of these agents $ [34–36] $. Table 1 summarizes some of the scaffolds/hydrogels incor,"[114.0, 850.0, 621.0, 944.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,6,text,"Zhao et al. introduced the designation of active scaffolds, which can offer the possibility of controlling the properties of the construct through an external stimulus as opposite to traditional porou","[113.0, 945.0, 622.0, 1185.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,7,text,Bock et al. proposed a promising new strategy based on the development of new magnetic scaffolds that could act as fixed ‘stations’ to attract growth factors and stem cells bound to MNPs [37]. This ap,"[112.0, 1186.0, 622.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,8,text,"of tumors [38,39]; however, the provided spatial accuracy and ther-
apeutic efficacy is also of major interest for tissue engineering
applications. The incorporation of SPMNs instead of the common
MNP","[634.0, 847.0, 1145.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,9,text,The use of magnetic forces can also be directed towards the improvement of the efficiency of cell seeding. This step is a critical parameter on tissue engineering strategies as the success of the cons,"[635.0, 1377.0, 1146.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,10,footer,www.expert-reviews.com,"[115.0, 1534.0, 327.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
3,11,number,555,"[1103.0, 1529.0, 1142.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,0,header,Review,"[88.0, 95.0, 182.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,1,header,"Santo, Rodrigues & Gomes","[206.0, 99.0, 459.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
4,2,figure_title,Table 1. Compilation of studies reporting the use of magnetic stimulation for the development of 3D constructs for tissue engineering and regenerative medicine.,"[74.0, 185.0, 1037.0, 237.0]",table_caption,0.9,"[""table prefix matched: Table 1. Compilation of studies reporting the use of magneti""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True
4,3,table,"<table><tr><td colspan=""6"">constructs for tissue engineering and regenerative medicine.</td></tr><tr><td>Construct fabrication strategies</td><td>Approach</td><td>Magnetic role</td><td>Experimental se","[74.0, 203.0, 1090.0, 1409.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True
4,4,vision_footnote,AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona,"[74.0, 1398.0, 1038.0, 1451.0]",footnote,0.7,"[""vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star""]",footnote,0.7,body_zone,body_like,none,True,True
4,5,number,556,"[71.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,6,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1533.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
5,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403.0, 99.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
5,1,header,Review,"[1031.0, 93.0, 1128.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,2,figure_title,Table 1. Compilation of studies reporting the use of magnetic stimulation for the development of 3D constructs for tissue engineering and regenerative medicine (cont.).,"[120.0, 183.0, 1080.0, 234.0]",table_caption,0.9,"[""table prefix matched: Table 1. Compilation of studies reporting the use of magneti""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True
5,3,table,"<table><tr><td>Construct fabrication strategies</td><td>Approach</td><td>Magnetic role</td><td>Experimental set up</td><td>Application</td><td>Ref.</td></tr><tr><td rowspan=""3"">Dispersion/impregnation","[117.0, 191.0, 1137.0, 1122.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True
5,4,vision_footnote,AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona,"[118.0, 1129.0, 1082.0, 1181.0]",footnote,0.7,"[""vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star""]",footnote,0.7,body_zone,body_like,none,True,True
5,5,text,"of the scaffolds and insufficient migration of the cells into the scaffolds lead to a shortage of initially seeded cells, resulting in less significant outcomes. In this context, the functionalization","[112.0, 1208.0, 623.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,6,text,"the formulations in which the magnetic force was applied, thus
demonstrating the potential of this novel design for tissue engi-
neering purposes. Depending on the scaffold, an improvement on
cell see","[634.0, 1207.0, 1145.0, 1424.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,7,text,Other methods in which the application of magnetic fields can be useful are the bottom-up scaffold fabrication techniques. The assembly of building blocks such as cell-encapsulating microscale,"[635.0, 1424.0, 1145.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,8,footer,www.expert-reviews.com,"[115.0, 1534.0, 328.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
5,9,number,557,"[1103.0, 1528.0, 1141.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,0,header,Review,"[87.0, 94.0, 183.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,1,header,"Santo, Rodrigues & Gomes","[206.0, 98.0, 458.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
6,2,text,"hydrogels mimics the structure of native tissues, typically composed by repeating functional units [43]. Despite the promising opportunities provided by this approach, the control over this assembly i","[67.0, 177.0, 577.0, 848.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,3,text,A recent report by Tasoglu et al. has shown that the magnetic assembly can be provided in the absence of MNPs [43]. The results demonstrate that PEG hydrogels that were exposed to UV radiation for lon,"[69.0, 849.0, 577.0, 898.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,4,text,"demonstrate that PEG hydrogels that were exposed to UV radia-
tion for longer periods traveled towards the magnets with higher
velocity. The exposure to UV induces the formation of free radi-
cals, wh","[588.0, 176.0, 1101.0, 849.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,5,text,"The fabrication of magnetically responsive hydrogels crosslinked with paramagnetic ions has also been pursued [48]. Typically, a","[589.0, 848.0, 1099.0, 899.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,6,image,,"[77.0, 925.0, 1086.0, 1362.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
6,7,figure_title,"Figure 2. Sequential magnetic fusion for the formation of a cartilage construct. (A) Sixteen spheroid aggregates were formed through the use of a network of magnetic tips, which were then placed in co","[80.0, 1386.0, 1080.0, 1489.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Sequential magnetic fusion for the formation of a ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
6,8,number,558,"[71.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,9,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1533.0, 1095.0, 1552.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
7,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[402.0, 99.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
7,1,header,Review,"[1031.0, 93.0, 1128.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
7,2,text,"correlation between the concentration of the paramagnetic ions and magnetic field gradient can be achieved. In an externally applied magnetic field, the paramagnetic hydrogel spheres assemble into ord","[111.0, 176.0, 622.0, 345.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,3,text,Another promising tissue engineering methodology where a 3D tissue is constructed without artificial scaffolds is the magnetically induced cell sheet technology (TABLE 1). MNPs can label specific cell,"[112.0, 344.0, 622.0, 1018.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,4,text,"The use of external magnetic fields present some limitations, namely the targeting challenge of deep tissues as the targeting efficiency depends on the distance between the magnet and the tissue of in","[112.0, 1017.0, 623.0, 1400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,5,text,"effect of labeling stem cells with MNPs. They induce mechani-
cal stimulation through different mechanisms, namely magnetic
twisting, mechanosensitive ion channel activation, targeted ion
channel acti","[633.0, 176.0, 1145.0, 320.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,6,text,"Furthermore, the mechanical stimulation induced by magnetic forces has also been shown to produce significant effects on cells, increasing their metabolic activity during the stimulation period [55]. ","[113.0, 1401.0, 623.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,7,text,"pi p y
general, no adverse effects are found.
Wu et al. demonstrated an enhancement of mitochondrial
activity and expression of bone-related genes in human bone
marrow MSCs adhered to iron-containing ","[633.0, 320.0, 1145.0, 825.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,8,text,"The feasibility of mechanical stimulation induced by magnetic forces has been shown to promote osteogenic and chondrogenic differentiation of MSCs [28,29] and to promote the organization of endothelia","[634.0, 824.0, 1144.0, 997.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,9,paragraph_title,Imaging & biosensing functionalities in tissue-engineered substitutes,"[635.0, 1015.0, 1062.0, 1064.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Imaging & biosensing functionalities in tissue-engineered su""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
7,10,text,"Major achievements in tissue engineering and regenerative medicine therapies are expected from a major challenge in nanomedicine, which consists of integrating selective targeting, imaging and directe","[633.0, 1065.0, 1145.0, 1500.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,11,footer,www.expert-reviews.com,"[114.0, 1534.0, 328.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
7,12,number,559,"[1103.0, 1529.0, 1142.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
8,0,header,Review,"[88.0, 94.0, 182.0, 123.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
8,1,header,"Santo, Rodrigues & Gomes","[207.0, 98.0, 458.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
8,2,image,,"[80.0, 184.0, 552.0, 1049.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
8,3,figure_title,"Figure 3. Endothelial cell organization in magnetic nanoparticle–alginate and alginate constructs. After the seeding into the MNP or alginate scaffold, the endothelial cells were exposed to an alterna","[79.0, 1076.0, 568.0, 1337.0]",figure_caption,0.92,"[""figure_title label: Figure 3. Endothelial cell organization in magnetic nanopart""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
8,4,text,"to lesion tissue [60], optical detectability and therapeutic delivery, as mentioned before.","[69.0, 1353.0, 574.0, 1400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,5,text,"The application of MNPs in MRI-based technologies is envisioned to improve spatial resolution and soft tissue contrast at a nanoscale level, while simultaneously imaging tissue anatomy, physiology and","[68.0, 1401.0, 577.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,6,text,"biomaterial systems. The detectability of MRI can be signifi-
cantly improved by the preferential accumulation of MNP contrast
agents if the targeting ligands, such as a protein or an antibody, are
at","[589.0, 175.0, 1099.0, 585.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,7,text,"SPMNs were described to be preferred to gadolinium chelates for cell labeling because they provide high signal contrasts in T2/T2*-weighted image sequences, are nontoxic and biodegradable [61].","[589.0, 585.0, 1098.0, 680.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,8,text,"In the particular field of tissue engineering, MNPs hold great promise as a detection method for cell selection, cell sorting, spatial control of target cells and cell aggregation and adherence proper","[589.0, 681.0, 1099.0, 849.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,9,text,"Tracking of implanted cells in regenerative medicine strategies is critical to evaluate cell migration and cellular functions, and to help guide treatment for maximized therapeutic effect [62]. Magnet","[590.0, 849.0, 1098.0, 1185.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,10,text,The work of Bulte et al. was pioneer on the development of magnetodendrimers for labeling of stem and progenitor cells through a nonspecific membrane adsorption process with a subsequent intracellular,"[590.0, 1185.0, 1098.0, 1352.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,11,text,"The group of Chien Ho has also explored the possibility of using MRI to noninvasively monitor individual immune cells, primarily macrophages in vivo, after heart and lung transplantation $ [65] $. Th","[589.0, 1353.0, 1099.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,12,number,560,"[72.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
8,13,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1532.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
9,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403.0, 99.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
9,1,header,Review,"[1031.0, 94.0, 1128.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
9,2,text,"to complement biopsy is highly desirable. This technique may also be applied to assess the inflammatory response to implanted constructs in tissue engineering strategies, allowing the in situ monitori","[112.0, 177.0, 622.0, 272.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,3,text,"Several protocols have already been described for in vivo tracking of human skeletal muscle cells [66]. Other protocols use cells as a circulating vehicle; for instance, erythrocytes have been explore","[112.0, 273.0, 622.0, 631.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,4,text,"Other studies on MSC tracking in limb ischemia revealed MNPs' low toxicity and MSC detection after transplantation $ [68] $. In a rabbit osteochondral model, alginate-incorporated MNPs guided by exte","[113.0, 632.0, 622.0, 849.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,5,text,"Some pioneer studies on the design techniques of these multimodal nanoparticles have already been published. Zhu et al. developed probes combining magnetic, fluorescence and thermoresponsive features ","[112.0, 848.0, 623.0, 1211.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,6,paragraph_title,Biosensing,"[115.0, 1233.0, 216.0, 1255.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Biosensing""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True
9,7,text,"The rapid and sensitive detection of molecular targets such as genetic material, proteins, enzymes, cytokines, growth factors, pathogens and metabolic byproducts secreted by cells is a major point in ","[112.0, 1256.0, 622.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,8,text,The detection and measurement of biomolecules in the culture medium where cell-laden tissue engineering systems are cultured gathers relevant information on in vitro cell behavior and thus of the tiss,"[113.0, 1377.0, 623.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,9,text,"methodologies. MNPs are also envisioned to play a role in the
detection, labeling and selective elimination of pathogens poten-
tially present in a culture medium or targeted antibacterial ther-
apy t","[634.0, 176.0, 1144.0, 369.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,10,text,"By incorporating advanced features, the detectability and applicability of MNPs have been dramatically expanded. Nevertheless, the location, distribution and long-term viability of tagged cells for cl","[634.0, 368.0, 1145.0, 512.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,11,text,Preclinical assays for cardiac applications are already being performed. Subcutaneous sensors were implanted in rodents for noninvasive measuring cardiac-specific biomarker levels in an attempt to pre,"[633.0, 513.0, 1145.0, 682.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,12,paragraph_title,Remote-controlled therapies,"[636.0, 705.0, 893.0, 726.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Remote-controlled therapies""]",subsection_heading,0.6,body_zone,body_like,none,True,True
9,13,text,"Magnetic field therapies, often referred as pulsed electromagnetic field (PEMF) therapies, are already applied in clinical practice to promote bone healing in delayed unions and nonunions $ [71] $ wi","[634.0, 729.0, 1144.0, 920.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,14,text,"Pilot clinical trials also indicate the beneficial effects of PEMF on pain relief $ [73,75,76] $, in particular the rapid impact on pain reduction from early knee osteoarthritis $ [75] $ or osteonec","[634.0, 920.0, 1144.0, 1064.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,15,text,One of the reported effects of this therapy includes the enhancement of metabolic activity of chondrocytes [77–79] and the prevention of the catabolic effects of inflammation [80–84] caused by osteoar,"[634.0, 1065.0, 1145.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,16,footer,www.expert-reviews.com,"[115.0, 1534.0, 328.0, 1554.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
9,17,number,561,"[1103.0, 1529.0, 1140.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
10,0,header,"Review Santo, Rodrigues & Gomes","[86.0, 96.0, 458.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
10,1,image,,"[78.0, 186.0, 1090.0, 421.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
10,2,figure_title,Figure 4. Magnet-scaffold configurations suggested by Russo et al. (A) External permanent magnetic ring (EM); (B) implanted permanent magnetic pins (PM); (C) implanted stainless steel pins in the fiel,"[79.0, 439.0, 1065.0, 561.0]",figure_caption,0.92,"[""figure_title label: Figure 4. Magnet-scaffold configurations suggested by Russo ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
10,3,text,"growth factors, including bone morphogenetic proteins and TGF $ [87,88] $. Angiogenesis $ [89,90] $ and mechanical properties $ [91] $ were also reported to be enhanced post-therapy.","[67.0, 584.0, 576.0, 656.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,4,text,"Despite the fact that remote-controlled therapies are poorly explored in the fields of cell and tissue engineering, increasing focus has been devoted to explore the remote control applications, includ","[68.0, 657.0, 576.0, 1233.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,5,text,"PEMF therapies have been already US FDA approved for several pathologies including nonunion bone fractures and arthritic pain, but studies directed to tissue engineering and regenerative medicine stra","[67.0, 1233.0, 577.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,6,text,"would stimulate implantable scaffolds. The incorporation of
MNPs in the scaffolds in combination with PEMF stimulation
would likely result in a synergistic therapeutic effect. In the case
of multifunc","[588.0, 583.0, 1099.0, 945.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,7,text,"Selective control of cell function by applying time-varying magnetic fields has added a new, exciting dimension to biology and medicine. The ability to remotely control cell or construct fate locally ","[588.0, 944.0, 1099.0, 1138.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,8,paragraph_title,Expert commentary,"[591.0, 1161.0, 779.0, 1183.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Expert commentary""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
10,9,text,"Besides sorting and isolation abilities, MNPs may also be used as pulsatile delivery systems for the release of selected growth factors. Magnetism is acknowledged as an advantageous physical stimulus ","[588.0, 1185.0, 1100.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,10,number,562,"[72.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
10,11,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1532.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
11,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[403.0, 99.0, 1006.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
11,1,header,Review,"[1032.0, 94.0, 1127.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
11,2,text,Probably the most challenging and innovative aspects of magnetic-based approaches consist of the integration of the theranostic tools provided by the MNPs into a 3D tissue-engineered construct as well,"[114.0, 177.0, 621.0, 323.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,3,paragraph_title,Five-year view,"[115.0, 345.0, 253.0, 367.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Five-year view""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
11,4,text,"The increased number of literature reports shows a clear tendency for a significant increase in research focusing on magnetic responsive systems and their potential in the regenerative medicine field,","[113.0, 368.0, 621.0, 464.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,5,text,"To fabricate 3D magnetic responsive tissue-engineered constructs with precisely controlled architectures, the ability to assemble cell-laden microscale magnetic hydrogels (M-gels) should be further ex","[114.0, 465.0, 621.0, 607.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,6,text,Research in this field is also expected to further explore the ability of magnetic systems to promote the release of relevant molecules through a magnetic switch on/off and their role on stem cell dev,"[115.0, 609.0, 622.0, 658.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,7,text,"molecules through a magnetic switch on/off and their role on stem
cell development as well as the ability for the ex vivo stimulation
of implanted devices.","[636.0, 177.0, 1143.0, 247.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,8,text,"Finally, a great deal of attention is also expected to be directed to the clarification of the long-term fate of embedded MNPs before considering the clinical application of magnetic tissue-engineered","[636.0, 249.0, 1144.0, 343.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,9,text,"In summary, in upcoming years, several advances are expected that will revolutionize the field as they hold the potential to overcome main obstacles to the routine use of tissue engineering therapies ","[636.0, 345.0, 1144.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,10,paragraph_title,Financial & competing interests disclosure,"[636.0, 465.0, 986.0, 487.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Financial & competing interests disclosure""]",subsection_heading,0.6,body_zone,body_like,none,True,True
11,11,text,The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in ,"[636.0, 491.0, 1145.0, 632.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,12,text,No writing assistance was utilized in the production of this manuscript.,"[653.0, 634.0, 1141.0, 657.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,13,paragraph_title,Key issues,"[121.0, 695.0, 225.0, 720.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Key issues""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
11,14,text,• Magnetic nanoparticles (MNPs) allow the development of magnetic responsive tissue-engineered systems that may enable pulsatile delivery of growth factors while simultaneously allowing magnetic stimu,"[120.0, 730.0, 1107.0, 794.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,15,text,• Magnetic responsive tissue-engineered systems may be obtained by direct incorporation of the MNPs into a 3D scaffold or hydrogel or by association of MNPs with stem cells that are subsequently seede,"[122.0, 797.0, 1129.0, 840.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,16,text,"• Magnetic responsive systems may allow simultaneous diagnostic and therapeutic functionalities; therapeutic functionalities include the possibility to enhance stem cells response, tailoring their loc","[120.0, 843.0, 1134.0, 993.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,17,paragraph_title,References,"[116.0, 1041.0, 220.0, 1062.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True
11,18,reference_content,"Papers of special note have been highlighted as:
• of interest","[116.0, 1065.0, 422.0, 1106.0]",reference_item,0.85,"[""reference content label: Papers of special note have been highlighted as:\n\u2022 of intere""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
11,19,reference_content,•• of considerable interest,"[117.0, 1105.0, 286.0, 1124.0]",reference_item,0.85,"[""reference content label: \u2022\u2022 of considerable interest""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
11,20,reference_content,"1 Santo VE, Gomes ME, Mano JF, Reis RL. From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering. Nanomedicine (Lo","[116.0, 1130.0, 435.0, 1255.0]",reference_item,0.85,"[""reference content label: 1 Santo VE, Gomes ME, Mano JF, Reis RL. From nano- to macro-""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,21,reference_content,"2 Li Y, Huang G, Zhang X et al. Magnetic hydrogels and their potential biomedical applications. Adv. Funct. Mater. 23(6), 660–672 (2013).","[115.0, 1263.0, 426.0, 1345.0]",reference_item,0.85,"[""reference content label: 2 Li Y, Huang G, Zhang X et al. Magnetic hydrogels and their""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,22,reference_content,"3 Santo VE, Duarte AR, Popa EG, Gomes ME, Mano JF, Reis RL. Enhancement of osteogenic differentiation of human adipose derived stem cells by the controlled release of platelet lysates from hybrid scaf","[114.0, 1353.0, 441.0, 1477.0]",reference_item,0.85,"[""reference content label: 3 Santo VE, Duarte AR, Popa EG, Gomes ME, Mano JF, Reis RL. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,23,reference_content,"foaming. J. Control. Release 162(1), 19–27 (2012).","[496.0, 1040.0, 784.0, 1081.0]",reference_item,0.85,"[""reference content label: foaming. J. Control. Release 162(1), 19\u201327 (2012).""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
11,24,reference_content,"4 Engel E, Michiardi A, Navarro M, Lacroix D, Planell JA. Nanotechnology in regenerative medicine: the materials side. Trends Biotechnol. 26(1), 39–47 (2008).","[465.0, 1090.0, 792.0, 1172.0]",reference_item,0.85,"[""reference content label: 4 Engel E, Michiardi A, Navarro M, Lacroix D, Planell JA. Na""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,25,reference_content,"5 Fleischer S, Dvir T. Tissue engineering on the nanoscale: lessons from the heart. Curr. Opin. Biotechnol. 24, 1–8 (2012)","[466.0, 1180.0, 790.0, 1242.0]",reference_item,0.85,"[""reference content label: 5 Fleischer S, Dvir T. Tissue engineering on the nanoscale: ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,26,reference_content,"6 Sekhon BS, Kamboj SR. Inorganic nanomedicine—part 1. Nanomedicine 6(4), 516–522 (2010).","[465.0, 1249.0, 785.0, 1310.0]",reference_item,0.85,"[""reference content label: 6 Sekhon BS, Kamboj SR. Inorganic nanomedicine\u2014part 1. Nanom""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,27,reference_content,"7 Shubayev VI, Pisanic TR 2nd, Jin S. Magnetic nanoparticles for theragnostics. Adv. Drug Deliv. Rev. 61(6), 467–477 (2009).","[464.0, 1317.0, 779.0, 1399.0]",reference_item,0.85,"[""reference content label: 7 Shubayev VI, Pisanic TR 2nd, Jin S. Magnetic nanoparticles""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,28,reference_content,"8 Singamaneni S, Bliznyuk VN, Binek C, Tsymbal EY. Magnetic nanoparticles: recent advances in synthesis, self-assembly","[465.0, 1408.0, 783.0, 1469.0]",reference_item,0.85,"[""reference content label: 8 Singamaneni S, Bliznyuk VN, Binek C, Tsymbal EY. Magnetic ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,29,reference_content,"and applications. J. Mater. Chem. 21(42), 16819–16845 (2011).","[844.0, 1040.0, 1127.0, 1081.0]",reference_item,0.85,"[""reference content label: and applications. J. Mater. Chem. 21(42), 16819\u201316845 (2011)""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
11,30,reference_content,"9 Bonnemain B. Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review. J. Drug Target. 6(3), 167–174 (1998).","[813.0, 1090.0, 1140.0, 1193.0]",reference_item,0.85,"[""reference content label: 9 Bonnemain B. Superparamagnetic agents in magnetic resonanc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,31,reference_content,"10 Zhu H, Tao J, Wang W et al. Magnetic, fluorescent, and thermo-responsive Fe(3)O(4)/rare earth incorporated poly(St-NIPAM) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance","[813.0, 1201.0, 1136.0, 1345.0]",reference_item,0.85,"[""reference content label: 10 Zhu H, Tao J, Wang W et al. Magnetic, fluorescent, and th""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,32,reference_content,"- Describes a multimodal imaging probe combining magnetic, fluorescent and thermoresponsive properties.","[813.0, 1354.0, 1121.0, 1419.0]",reference_item,0.85,"[""reference content label: - Describes a multimodal imaging probe combining magnetic, f""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
11,33,reference_content,"11 Daniel-Da-Silva AL, Fateixa S, Guiomar AJ et al. Biofunctionalized magnetic hydrogel nanospheres of magnetite and","[813.0, 1426.0, 1123.0, 1488.0]",reference_item,0.85,"[""reference content label: 11 Daniel-Da-Silva AL, Fateixa S, Guiomar AJ et al. Biofunct""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
11,34,footer,www.expert-reviews.com,"[115.0, 1535.0, 327.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False
11,35,number,563,"[1103.0, 1529.0, 1141.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,short_fragment,False,False
12,0,header,Review,"[88.0, 94.0, 183.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False
12,1,header,"Santo, Rodrigues & Gomes","[207.0, 98.0, 458.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
12,2,reference_content,"κ-carrageenan. Nanotechnology 20(35), 355602 (2009).","[102.0, 177.0, 368.0, 217.0]",reference_item,0.85,"[""reference content label: \u03ba-carrageenan. Nanotechnology 20(35), 355602 (2009).""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
12,3,reference_content,"12 Santo VE, Gomes ME, Mano JF, Reis RL. Chitosan-chondroitin sulphate nanoparticles for controlled delivery of platelet lysates in bone regenerative medicine. J. Tissue Eng. Regen. Med. 6(Suppl. 3), ","[73.0, 224.0, 401.0, 348.0]",reference_item,0.85,"[""reference content label: 12 Santo VE, Gomes ME, Mano JF, Reis RL. Chitosan-chondroiti""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,4,reference_content,"13 Balmayor ER, Pashkuleva I, Frias AM, Azevedo HS, Reis RL. Synthesis and functionalization of superparamagnetic poly-e-caprolactone microparticles for the selective isolation of subpopulations of hu","[72.0, 356.0, 399.0, 501.0]",reference_item,0.85,"[""reference content label: 13 Balmayor ER, Pashkuleva I, Frias AM, Azevedo HS, Reis RL.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,5,reference_content,"14 Hsiao JK, Tai MF, Chu HH et al. Magnetic nanoparticle labeling of mesenchymal stem cells without transfection agent: cellular behavior and capability of detection with clinical 1.5 T magnetic reson","[73.0, 510.0, 395.0, 656.0]",reference_item,0.85,"[""reference content label: 14 Hsiao JK, Tai MF, Chu HH et al. Magnetic nanoparticle lab""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,6,reference_content,"15 Markides H, Rotherham M, El Haj AJ. Biocompatibility and toxicity of magnetic nanoparticles in regenerative medicine. J. Nanomater. 2012, 1–11 (2012).","[74.0, 663.0, 388.0, 746.0]",reference_item,0.85,"[""reference content label: 15 Markides H, Rotherham M, El Haj AJ. Biocompatibility and ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,7,reference_content,"16 Perea H, Aigner J, Heverhagen JT, Hopfner U, Wintermantel E. Vascular tissue engineering with magnetic nanoparticles: seeing deeper. J. Tissue Eng. Regen. Med. 1(4), 318–321 (2007).","[75.0, 753.0, 396.0, 856.0]",reference_item,0.85,"[""reference content label: 16 Perea H, Aigner J, Heverhagen JT, Hopfner U, Wintermantel""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,8,reference_content,"17 Samberg ME, Loboa EG, Oldenburg SJ, Monteiro-Riviere NA. Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity. Nanomedicine (Lond.) 7(8), 1197–1209 (2012).","[74.0, 864.0, 393.0, 967.0]",reference_item,0.85,"[""reference content label: 17 Samberg ME, Loboa EG, Oldenburg SJ, Monteiro-Riviere NA. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,9,reference_content,"18 Wimpenny I, Markides H, El Haj AJ. Orthopaedic applications of nanoparticle-based stem cell therapies. Stem Cell Res. Ther. 3(2), 13 (2012).","[73.0, 975.0, 388.0, 1056.0]",reference_item,0.85,"[""reference content label: 18 Wimpenny I, Markides H, El Haj AJ. Orthopaedic applicatio""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,10,reference_content,"19 Xu F, Wu CA, Rengarajan V et al. Three-dimensional magnetic assembly of microscale hydrogels. Adv. Mater. Weinheim 23(37), 4254–4260 (2011).","[74.0, 1065.0, 385.0, 1147.0]",reference_item,0.85,"[""reference content label: 19 Xu F, Wu CA, Rengarajan V et al. Three-dimensional magnet""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,11,reference_content,"20 Lee JM, Kim BS, Lee H, Im GI. In vivo tracking of mesenchymal stem cells using fluorescent nanoparticles in an osteochondral repair model. Mol. Ther. 20(7), 1434–1442 (2012).","[73.0, 1156.0, 390.0, 1257.0]",reference_item,0.85,"[""reference content label: 20 Lee JM, Kim BS, Lee H, Im GI. In vivo tracking of mesench""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,12,reference_content,"21 Hughes S, Dobson J, El Haj AJ. Magnetic targeting of mechanosensors in bone cells for tissue engineering applications. J. Biomech. 40(Suppl. 1), S96–104 (2007).","[73.0, 1266.0, 391.0, 1349.0]",reference_item,0.85,"[""reference content label: 21 Hughes S, Dobson J, El Haj AJ. Magnetic targeting of mech""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,13,reference_content,"22 Kanczler JM, Sura HS, Magnay J et al. Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology. Tissue Eng. Part A 16(10), 3241–3250 (2010).","[71.0, 1356.0, 397.0, 1459.0]",reference_item,0.85,"[""reference content label: 22 Kanczler JM, Sura HS, Magnay J et al. Controlled differen""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,14,reference_content,"23 Tseng P, Judy JW, Di Carlo D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Nat. Methods 9(11), 1113–1119 (2012).","[419.0, 177.0, 731.0, 279.0]",reference_item,0.85,"[""reference content label: 23 Tseng P, Judy JW, Di Carlo D. Magnetic nanoparticle-media""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
12,15,reference_content,"24 Villa C, Erratico S, Razini P et al. Stem cell tracking by nanotechnologies. Int. J. Mol. Sci. 11(3), 1070–1081 (2010).","[420.0, 287.0, 748.0, 349.0]",reference_item,0.85,"[""reference content label: 24 Villa C, Erratico S, Razini P et al. Stem cell tracking b""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,16,reference_content,"25 Fayol D, Frasca G, Le Visage C, Gazeau F, Luciani N, Wilhelm C. Use of magnetic forces to promote stem cell aggregation during differentiation, and cartilage tissue modeling. Adv. Mater. Weinheim 2","[419.0, 357.0, 742.0, 480.0]",reference_item,0.85,"[""reference content label: 25 Fayol D, Frasca G, Le Visage C, Gazeau F, Luciani N, Wilh""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,17,reference_content,• Description of a sequential and modular process for the magnetically induced assembly of large constructs without core necrosis.,"[419.0, 490.0, 740.0, 574.0]",reference_item,0.85,"[""reference content label: \u2022 Description of a sequential and modular process for the ma""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
12,18,reference_content,"26 Grogan SP, Pauli C, Chen P et al. In situ tissue engineering using magnetically guided three-dimensional cell patterning. Tissue Eng. Part C. Methods 18(7), 496–506 (2012).","[420.0, 582.0, 733.0, 685.0]",reference_item,0.85,"[""reference content label: 26 Grogan SP, Pauli C, Chen P et al. In situ tissue engineer""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
12,19,reference_content,"27 Sniadecki NJ, Anguelouch A, Yang MT et al. Magnetic microposts as an approach to apply forces to living cells. Proc. Natl Acad. Sci. USA 104(37), 14553–14558 (2007).","[419.0, 694.0, 736.0, 797.0]",reference_item,0.85,"[""reference content label: 27 Sniadecki NJ, Anguelouch A, Yang MT et al. Magnetic micro""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,20,reference_content,"28 Bancroft GN, Sikavitsas VI, Mikos AG. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng. 9(3), 549–554 (2003).","[420.0, 806.0, 722.0, 908.0]",reference_item,0.85,"[""reference content label: 28 Bancroft GN, Sikavitsas VI, Mikos AG. Design of a flow pe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,21,reference_content,"29 Bancroft GN, Sikavitsas VI, van den Dolder J et al. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc. Natl A","[419.0, 917.0, 726.0, 1061.0]",reference_item,0.85,"[""reference content label: 29 Bancroft GN, Sikavitsas VI, van den Dolder J et al. Fluid""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,22,reference_content,"30 Sun S, Anders S, Hamann HF et al. Polymer mediated self-assembly of magnetic nanoparticles. J. Am. Chem. Soc. 124(12), 2884–2885 (2002).","[420.0, 1070.0, 738.0, 1151.0]",reference_item,0.85,"[""reference content label: 30 Sun S, Anders S, Hamann HF et al. Polymer mediated self-a""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,23,reference_content,"31 Hu S-H, Liu T-Y, Tsai C-H, Chen S-Y. Preparation and characterization of magnetic ferroscaffolds for tissue engineering. J. Magn. Magn. Mater. 310(2, Pt 3), 2871–2873 (2007).","[420.0, 1160.0, 739.0, 1262.0]",reference_item,0.85,"[""reference content label: 31 Hu S-H, Liu T-Y, Tsai C-H, Chen S-Y. Preparation and char""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,24,reference_content,"32 Paulino AT, Pereira AG, Fajardo AR et al. Natural polymer-based magnetic hydrogels: potential vectors for remote-controlled drug release. Carbohydr. Polym. 90(3), 1216–1225 (2012).","[420.0, 1271.0, 747.0, 1373.0]",reference_item,0.85,"[""reference content label: 32 Paulino AT, Pereira AG, Fajardo AR et al. Natural polymer""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,25,reference_content,"33 Skaat H, Ziv-Polat O, Shahar A, Last D, Mardor Y, Margel S. Magnetic scaffolds enriched with bioactive nanoparticles for tissue engineering. Adv. Healthc. Mater. 1(2), 168–171 (2012).","[420.0, 1382.0, 730.0, 1484.0]",reference_item,0.85,"[""reference content label: 33 Skaat H, Ziv-Polat O, Shahar A, Last D, Mardor Y, Margel ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,26,reference_content,"34 Zhao X, Kim J, Cezar CA et al. Active scaffolds for on-demand drug and cell delivery. Proc. Natl Acad. Sci. USA 108(1), 67–72 (2011).","[767.0, 174.0, 1093.0, 256.0]",reference_item,0.85,"[""reference content label: 34 Zhao X, Kim J, Cezar CA et al. Active scaffolds for on-de""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,27,reference_content,Key work on the development of magnetic constructs for tissue engineering applications.,"[767.0, 265.0, 1095.0, 330.0]",reference_item,0.85,"[""reference content label: Key work on the development of magnetic constructs for tissu""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
12,28,reference_content,"35 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release strategies for bone, cartilage, and osteochondral engineering-part I: recapitulation of native tissue healing and variables for the design o","[767.0, 337.0, 1086.0, 480.0]",reference_item,0.85,"[""reference content label: 35 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,29,reference_content,"36 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release strategies for bone, cartilage, and osteochondral engineering—part II: challenges on the evolution from single to multiple bioactive factor ","[767.0, 490.0, 1088.0, 633.0]",reference_item,0.85,"[""reference content label: 36 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,30,reference_content,"37 Bock N, Riminucci A, Dionigi C et al. A novel route in bone tissue engineering: magnetic biomimetic scaffolds. Acta Biomater. 6(3), 786–796 (2010).","[767.0, 642.0, 1078.0, 725.0]",reference_item,0.85,"[""reference content label: 37 Bock N, Riminucci A, Dionigi C et al. A novel route in bo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,31,reference_content,"38 Kobayashi T. Cancer hyperthermia using magnetic nanoparticles. Biotechnol. J. 6(11), 1342–1347 (2011).","[767.0, 734.0, 1080.0, 794.0]",reference_item,0.85,"[""reference content label: 38 Kobayashi T. Cancer hyperthermia using magnetic nanoparti""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,32,reference_content,"39 Wang L, Dong J, Ouyang W, Wang X, Tang J. Anticancer effect and feasibility study of hyperthermia treatment of pancreatic cancer using magnetic nanoparticles. Oncol. Rep. 27(3), 719–726 (2012).","[766.0, 802.0, 1088.0, 925.0]",reference_item,0.85,"[""reference content label: 39 Wang L, Dong J, Ouyang W, Wang X, Tang J. Anticancer effe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,33,reference_content,"40 Campbell SB, Patenaude M, Hoare T. Injectable superparamagnets: highly elastic and degradable poly (N-isopropylacrylamide)-superparamagnetic iron oxide nanoparticle (SPION) composite hydrogels. Bio","[766.0, 934.0, 1091.0, 1079.0]",reference_item,0.85,"[""reference content label: 40 Campbell SB, Patenaude M, Hoare T. Injectable superparama""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,34,reference_content,"41 Shimizu K, Ito A, Honda H. Enhanced cell-seeding into 3D porous scaffolds by use of magnetite nanoparticles. J. Biomed. Mater. Res. Part B Appl. Biomater. 77(2), 265–272 (2006).","[767.0, 1087.0, 1084.0, 1189.0]",reference_item,0.85,"[""reference content label: 41 Shimizu K, Ito A, Honda H. Enhanced cell-seeding into 3D ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,35,reference_content,"42 Thevenot P, Sohaebuddin S, Poudyal N, Liu JP, Tang L. Magnetic Nanoparticles to Enhance Cell Seeding and Distribution in Tissue Engineering Scaffolds. Proc. IEEE Conf. Nanotechnol. 2008, 646–649 (2","[767.0, 1197.0, 1092.0, 1301.0]",reference_item,0.85,"[""reference content label: 42 Thevenot P, Sohaebuddin S, Poudyal N, Liu JP, Tang L. Mag""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,36,reference_content,"43 Tasoglu S, Kavaz D, Gurkan UA et al. Paramagnetic levitational assembly of hydrogels. Adv. Mater. Weinheim 25(8), 1137–43, 1081 (2013).","[767.0, 1309.0, 1071.0, 1391.0]",reference_item,0.85,"[""reference content label: 43 Tasoglu S, Kavaz D, Gurkan UA et al. Paramagnetic levitat""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,37,reference_content,"44 Lu T, Li Y, Chen T. Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering. Int. J. Nanomed. 8, 337–350 (2013).","[766.0, 1399.0, 1078.0, 1482.0]",reference_item,0.85,"[""reference content label: 44 Lu T, Li Y, Chen T. Techniques for fabrication and constr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,38,number,564,"[72.0, 1529.0, 110.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
12,39,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1533.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
13,0,header,Use of magnetic nanoparticles as diagnostic & therapeutic tools,"[404.0, 100.0, 1007.0, 124.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
13,1,header,Review,"[1032.0, 94.0, 1127.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False
13,2,reference_content,"45 Souza GR, Molina JR, Raphael RM et al. Three-dimensional tissue culture based on magnetic cell levitation. Nat. Nanotechnol. 5(4), 291–296 (2010).","[117.0, 176.0, 437.0, 258.0]",reference_item,0.85,"[""reference content label: 45 Souza GR, Molina JR, Raphael RM et al. Three-dimensional ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,3,reference_content,"46 Daquinag AC, Souza GR, Kolonin MG. Adipose tissue engineering in three-dimensional levitation tissue culture system based on magnetic nanoparticles. Tissue Eng. Part C. Methods 19(5), 336–344 (2013","[118.0, 267.0, 443.0, 390.0]",reference_item,0.85,"[""reference content label: 46 Daquinag AC, Souza GR, Kolonin MG. Adipose tissue enginee""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
13,4,reference_content,"47 Tseng H, Gage JA, Raphael RM et al. Assembly of a three-dimensional multitype bronchiole coculture model using magnetic levitation. Tissue Eng. Part C Methods doi:10.1089/ten.tec.2012.0157 (2013) (","[117.0, 399.0, 443.0, 524.0]",reference_item,0.85,"[""reference content label: 47 Tseng H, Gage JA, Raphael RM et al. Assembly of a three-d""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
13,5,reference_content,"48 Winkleman A, Bracher PJ, Gitlin I, Whitesides GM. Fabrication and manipulation of ionotropic hydrogels crosslinked by paramagnetic ions. Chem. Mater. 19(6), 1362–1368 (2007).","[117.0, 531.0, 441.0, 633.0]",reference_item,0.85,"[""reference content label: 48 Winkleman A, Bracher PJ, Gitlin I, Whitesides GM. Fabrica""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,6,reference_content,"49 Ito A, Hayashida M, Honda H et al. Construction and harvest of multilayered keratinocyte sheets using magnetite nanoparticles and magnetic force. Tissue Eng. 10(5-6), 873–880 (2004).","[118.0, 642.0, 431.0, 745.0]",reference_item,0.85,"[""reference content label: 49 Ito A, Hayashida M, Honda H et al. Construction and harve""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,7,reference_content,"50 Akiyama H, Ito A, Kawabe Y, Kamihira M. Genetically engineered angiogenic cell sheets using magnetic force-based gene delivery and tissue fabrication techniques. Biomaterials 31(6), 1251–1259 (2010","[118.0, 753.0, 444.0, 855.0]",reference_item,0.85,"[""reference content label: 50 Akiyama H, Ito A, Kawabe Y, Kamihira M. Genetically engin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,8,reference_content,• Generation of cell sheets through magnetic technology for the enhancement of vascularization.,"[117.0, 866.0, 443.0, 927.0]",reference_item,0.85,"[""reference content label: \u2022 Generation of cell sheets through magnetic technology for ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
13,9,reference_content,"51 Kito T, Shibata R, Ishii M et al. iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis. Sci. Rep. 3, 1418 (2013).","[119.0, 936.0, 428.0, 1019.0]",reference_item,0.85,"[""reference content label: 51 Kito T, Shibata R, Ishii M et al. iPS cell sheets created""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,10,reference_content,"52 Ito A, Ino K, Hayashida M et al. Novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force. Tissue Eng. 11(9-10), 1553–1561 (2005).","[118.0, 1026.0, 418.0, 1149.0]",reference_item,0.85,"[""reference content label: 52 Ito A, Ino K, Hayashida M et al. Novel methodology for fa""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,11,reference_content,"53 Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel S. Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigat","[118.0, 1158.0, 440.0, 1302.0]",reference_item,0.85,"[""reference content label: 53 Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel S. C""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,12,reference_content,"54 Russo A, Shelyakova T, Casino D et al. A new approach to scaffold fixation by magnetic forces: application to large osteochondral defects. Med. Eng. Phys. 34(9), 1287–1293 (2012).","[118.0, 1312.0, 414.0, 1415.0]",reference_item,0.85,"[""reference content label: 54 Russo A, Shelyakova T, Casino D et al. A new approach to ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,13,reference_content,"55 Sapir Y, Cohen S, Friedman G, Polyak B. The promotion of in vitro vessel-like organization of endothelial cells in","[118.0, 1423.0, 429.0, 1485.0]",reference_item,0.85,"[""reference content label: 55 Sapir Y, Cohen S, Friedman G, Polyak B. The promotion of ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,14,reference_content,"magnetically responsive alginate scaffolds. Biomaterials 33(16), 4100–4109 (2012).","[496.0, 177.0, 782.0, 217.0]",reference_item,0.85,"[""reference content label: magnetically responsive alginate scaffolds. Biomaterials 33(""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
13,15,reference_content,"56 Wu C, Fan W, Zhu Y et al. Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure. Acta Biomater. 7(10), 3563–3572 (2011).","[467.0, 225.0, 791.0, 307.0]",reference_item,0.85,"[""reference content label: 56 Wu C, Fan W, Zhu Y et al. Multifunctional magnetic mesopo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,16,reference_content,"57 Tourdias T, Roggerone S, Filippi M et al. Assessment of disease activity in multiple sclerosis phenotypes with combined gadolinium- and superparamagnetic iron oxide-enhanced MR imaging. Radiology 2","[464.0, 315.0, 778.0, 438.0]",reference_item,0.85,"[""reference content label: 57 Tourdias T, Roggerone S, Filippi M et al. Assessment of d""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,17,reference_content,"58 Yilmaz A, Dengler MA, van der Kuip H et al. Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magne","[464.0, 447.0, 791.0, 592.0]",reference_item,0.85,"[""reference content label: 58 Yilmaz A, Dengler MA, van der Kuip H et al. Imaging of my""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,18,reference_content,"59 Laurencin M, Cam N, Georgelin T et al. Human erythrocytes covered with magnetic core-shell nanoparticles for multimodal imaging. Adv. Healthc. Mater. doi:10.1002/adhm.201200384 (2013) (Epub ahead o","[466.0, 600.0, 794.0, 724.0]",reference_item,0.85,"[""reference content label: 59 Laurencin M, Cam N, Georgelin T et al. Human erythrocytes""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,19,reference_content,"60 Ling Y, Pong T, Vassiliou CC, Huang PL, Cima MJ. Implantable magnetic relaxation sensors measure cumulative exposure to cardiac biomarkers. Nat. Biotechnol. 29(3), 273–277 (2011).","[465.0, 732.0, 789.0, 834.0]",reference_item,0.85,"[""reference content label: 60 Ling Y, Pong T, Vassiliou CC, Huang PL, Cima MJ. Implanta""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,20,reference_content,• Development of implantable magnetic sensors as a tool for monitoring biomarkers in high-risk cardiac patients.,"[465.0, 844.0, 778.0, 908.0]",reference_item,0.85,"[""reference content label: \u2022 Development of implantable magnetic sensors as a tool for ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
13,21,reference_content,"61 Andreas K, Georgieva R, Ladwig M et al. Highly efficient magnetic stem cell labeling with citrate-coated superparamagnetic iron oxide nanoparticles for MRI tracking. Biomaterials 33(18), 4515–4525 ","[466.0, 916.0, 793.0, 1017.0]",reference_item,0.85,"[""reference content label: 61 Andreas K, Georgieva R, Ladwig M et al. Highly efficient ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,22,reference_content,"62 Cromer Berman SM, Walczak P, Bulte JW. Tracking stem cells using magnetic nanoparticles. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 3(4), 343–355 (2011).","[465.0, 1026.0, 789.0, 1128.0]",reference_item,0.85,"[""reference content label: 62 Cromer Berman SM, Walczak P, Bulte JW. Tracking stem cell""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,23,reference_content,"63 Frank JA, Miller BR, Arbab AS et al. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 228(2), 480–487 (2003).","[466.0, 1138.0, 789.0, 1241.0]",reference_item,0.85,"[""reference content label: 63 Frank JA, Miller BR, Arbab AS et al. Clinically applicabl""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,24,reference_content,"64 Bulte JW, Douglas T, Witwer B et al. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat. Biotechnol. 19(12), 1141–1147 (2001).","[465.0, 1248.0, 780.0, 1351.0]",reference_item,0.85,"[""reference content label: 64 Bulte JW, Douglas T, Witwer B et al. Magnetodendrimers al""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,25,reference_content,"65 Wu YL, Ye Q, Foley LM et al. In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc. Natl Acad. Sci. USA 103(6), 1852–1857 (2006).","[464.0, 1361.0, 787.0, 1463.0]",reference_item,0.85,"[""reference content label: 65 Wu YL, Ye Q, Foley LM et al. In situ labeling of immune c""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,26,reference_content,"66 Libani IV, Lucignani G, Gianelli U et al. Labeling protocols for in vivo tracking of human skeletal muscle cells (HSkMCs) by magnetic resonance and bioluminescence imaging. Mol. Imaging Biol. 14(1)","[812.0, 176.0, 1134.0, 300.0]",reference_item,0.85,"[""reference content label: 66 Libani IV, Lucignani G, Gianelli U et al. Labeling protoc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,27,reference_content,"67 Xu C, Miranda-Nieves D, Ankrum JA et al. Tracking mesenchymal stem cells with iron oxide nanoparticle loaded poly(lactide-co-glycolide) microparticles. Nano Lett. 12(8), 4131–4139 (2012).","[812.0, 309.0, 1126.0, 412.0]",reference_item,0.85,"[""reference content label: 67 Xu C, Miranda-Nieves D, Ankrum JA et al. Tracking mesench""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,28,reference_content,"68 Liu H, Li Y, Wang XY et al. Synthesis, preliminary structure-activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflamm","[812.0, 420.0, 1140.0, 564.0]",reference_item,0.85,"[""reference content label: 68 Liu H, Li Y, Wang XY et al. Synthesis, preliminary struct""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,29,reference_content,"69 Huang H, Delikanli S, Zeng H, Ferkey DM, Pralle A. Remote control of ion channels and neurons through magnetic-field heating of nanoparticles. Nat. Nanotechnol. 5(8), 602–606 (2010).","[813.0, 573.0, 1128.0, 676.0]",reference_item,0.85,"[""reference content label: 69 Huang H, Delikanli S, Zeng H, Ferkey DM, Pralle A. Remote""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,30,reference_content,"70 Durmus NG, Webster TJ. Eradicating antibiotic-resistant biofilms with silver-conjugated superparamagnetic iron oxide nanoparticles. Adv. Healthc. Mater. 2(1), 165–171 (2013).","[813.0, 684.0, 1143.0, 786.0]",reference_item,0.85,"[""reference content label: 70 Durmus NG, Webster TJ. Eradicating antibiotic-resistant b""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,31,reference_content,"71 Assiotis A, Sachinis NP, Chalidis BE. Pulsed electromagnetic fields for the treatment of tibial delayed unions and nonunions. A prospective clinical study and review of the literature. J. Orthop. S","[813.0, 794.0, 1143.0, 919.0]",reference_item,0.85,"[""reference content label: 71 Assiotis A, Sachinis NP, Chalidis BE. Pulsed electromagne""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,32,reference_content,"72 Abdelrahim A, Hassanein HR, Dahaba M. Effect of pulsed electromagnetic field on healing of mandibular fracture: a preliminary clinical study. J. Oral Maxillofac. Surg. 69(6), 1708–1717 (2011).","[813.0, 927.0, 1140.0, 1030.0]",reference_item,0.85,"[""reference content label: 72 Abdelrahim A, Hassanein HR, Dahaba M. Effect of pulsed el""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,33,reference_content,"73 Marcheggiani Muccioli GM, Grassi A, Setti S et al. Conservative treatment of spontaneous osteonecrosis of the knee in the early stage: pulsed electromagnetic fields therapy. Eur. J. Radiol. 82(3), ","[813.0, 1038.0, 1122.0, 1161.0]",reference_item,0.85,"[""reference content label: 73 Marcheggiani Muccioli GM, Grassi A, Setti S et al. Conser""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,34,reference_content,"74 Markov MS. Expanding use of pulsed electromagnetic field therapies. Electro-magn. Biol. Med. 26(3), 257–274 (2007).","[813.0, 1170.0, 1125.0, 1232.0]",reference_item,0.85,"[""reference content label: 74 Markov MS. Expanding use of pulsed electromagnetic field ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,35,reference_content,"75 Nelson F, Zvirbulis R, Pilla AA. Non-invasive electromagnetic field therapy produces rapid and substantial pain reduction in early knee osteoarthritis: a randomized double-blind pilot study. Osteoa","[812.0, 1239.0, 1116.0, 1382.0]",reference_item,0.85,"[""reference content label: 75 Nelson F, Zvirbulis R, Pilla AA. Non-invasive electromagn""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,36,reference_content,"76 Brook J, Dauphinee DM, Korpinen J, Rawe IM. Pulsed radiofrequency electromagnetic field therapy: a potential novel treatment of plantar fasciitis. J. Foot Ankle Surg. 51(3), 312–316 (2012).","[812.0, 1392.0, 1133.0, 1496.0]",reference_item,0.85,"[""reference content label: 76 Brook J, Dauphinee DM, Korpinen J, Rawe IM. Pulsed radiof""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,37,footer,www.expert-reviews.com,"[115.0, 1535.0, 327.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
13,38,number,565,"[1103.0, 1530.0, 1141.0, 1549.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
14,0,header,Review,"[88.0, 95.0, 183.0, 122.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,short_fragment,False,False
14,1,header,"Santo, Rodrigues & Gomes","[207.0, 99.0, 458.0, 121.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
14,2,reference_content,"77 De Mattei M, Caruso A, Pezzetti F et al. Effects of pulsed electromagnetic fields on human articular chondrocyte proliferation. Connect. Tissue Res. 42(4), 269–279 (2001).","[71.0, 174.0, 396.0, 276.0]",reference_item,0.85,"[""reference content label: 77 De Mattei M, Caruso A, Pezzetti F et al. Effects of pulse""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,3,reference_content,"78 De Mattei M, Fini M, Setti S et al. Proteoglycan synthesis in bovine articular cartilage explants exposed to different low-frequency low-energy pulsed electromagnetic fields. Osteoarthr. Cartil. 15","[72.0, 285.0, 389.0, 408.0]",reference_item,0.85,"[""reference content label: 78 De Mattei M, Fini M, Setti S et al. Proteoglycan synthesi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,4,reference_content,"79 Chang CH, Loo ST, Liu HL, Fang HW, Lin HY. Can low frequency electromagnetic field help cartilage tissue engineering? J. Biomed. Mater. Res. A 92(3), 843–851 (2010).","[72.0, 417.0, 398.0, 519.0]",reference_item,0.85,"[""reference content label: 79 Chang CH, Loo ST, Liu HL, Fang HW, Lin HY. Can low freque""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,5,reference_content,"80 De Mattei M, Pasello M, Pellati A et al. Effects of electromagnetic fields on proteoglycan metabolism of bovine articular cartilage explants. Connect. Tissue Res. 44(3-4), 154–159 (2003).","[73.0, 528.0, 396.0, 631.0]",reference_item,0.85,"[""reference content label: 80 De Mattei M, Pasello M, Pellati A et al. Effects of elect""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,6,reference_content,"81 Fioravanti A, Nerucci F, Collodel G, Markoll R, Marcolongo R. Biochemical and morphological study of human articular chondrocytes cultivated in the presence of pulsed signal therapy. Ann. Rheum. Di","[73.0, 639.0, 377.0, 763.0]",reference_item,0.85,"[""reference content label: 81 Fioravanti A, Nerucci F, Collodel G, Markoll R, Marcolong""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,7,reference_content,"82 Bobacz K, Graninger WB, Amoyo L, Smolen JS. Effect of pulsed electromagnetic fields on proteoglycan biosynthesis of articular cartilage is age dependent. Ann. Rheum. Dis. 65(7), 949–951 (2006).","[72.0, 773.0, 399.0, 874.0]",reference_item,0.85,"[""reference content label: 82 Bobacz K, Graninger WB, Amoyo L, Smolen JS. Effect of pul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,8,reference_content,"83 Ongaro A, Pellati A, Masieri FF et al. Chondroprotective effects of pulsed","[73.0, 883.0, 358.0, 923.0]",reference_item,0.85,"[""reference content label: 83 Ongaro A, Pellati A, Masieri FF et al. Chondroprotective ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,9,reference_content,"electromagnetic fields on human cartilage explants. Bioelectromagnetics 32(7), 543–551 (2011).","[448.0, 177.0, 737.0, 238.0]",reference_item,0.85,"[""reference content label: electromagnetic fields on human cartilage explants. Bioelect""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
14,10,reference_content,"84 Ongaro A, Varani K, Masieri FF et al. Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E(2) and cytokine release in human osteoarthritic synovial fibroblasts. J. Cell. P","[420.0, 246.0, 725.0, 390.0]",reference_item,0.85,"[""reference content label: 84 Ongaro A, Varani K, Masieri FF et al. Electromagnetic fie""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,11,reference_content,"85 Fini M, Pagani S, Giavaresi G et al. Functional tissue engineering in articular cartilage repair: is there a role for electromagnetic biophysical stimulation? Tissue Eng. Part B Rev. doi:10.1089/te","[420.0, 399.0, 734.0, 544.0]",reference_item,0.85,"[""reference content label: 85 Fini M, Pagani S, Giavaresi G et al. Functional tissue en""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,12,reference_content,"86 de Girolamo L, Stanco D, Galliera E et al. Low frequency pulsed electromagnetic field affects proliferation, tissue-specific gene expression, and cytokines release of human tendon cells. Cell Bioch","[421.0, 551.0, 746.0, 677.0]",reference_item,0.85,"[""reference content label: 86 de Girolamo L, Stanco D, Galliera E et al. Low frequency ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,13,reference_content,"87 Hannouche D, Petite H, Sedel L. Current trends in the enhancement of fracture healing. J. Bone Joint Surg. Br. 83(2), 157–164 (2001).","[421.0, 684.0, 737.0, 765.0]",reference_item,0.85,"[""reference content label: 87 Hannouche D, Petite H, Sedel L. Current trends in the enh""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,14,reference_content,"88 Kuzyk PR, Schemitsch EH. The science of electrical stimulation therapy for fracture healing. Indian J. Orthop. 43(2), 127–131 (2009).","[421.0, 774.0, 742.0, 855.0]",reference_item,0.85,"[""reference content label: 88 Kuzyk PR, Schemitsch EH. The science of electrical stimul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,15,reference_content,"89 Callaghan MJ, Chang EI, Seiser N et al. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by","[421.0, 863.0, 726.0, 926.0]",reference_item,0.85,"[""reference content label: 89 Callaghan MJ, Chang EI, Seiser N et al. Pulsed electromag""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,16,reference_content,"increasing endogenous FGF-2 release. Plast. Reconstr. Surg. 121(1), 130–141 (2008).","[797.0, 178.0, 1055.0, 238.0]",reference_item,0.85,"[""reference content label: increasing endogenous FGF-2 release. Plast. Reconstr. Surg. ""]",reference_item,0.85,reference_zone,unknown_like,none,True,True
14,17,reference_content,"90 Smith TL, Wong-Gibbons D, Maultsby J. Microcirculatory effects of pulsed electromagnetic fields. J. Orthop. Res. 22(1), 80–84 (2004).","[766.0, 246.0, 1083.0, 327.0]",reference_item,0.85,"[""reference content label: 90 Smith TL, Wong-Gibbons D, Maultsby J. Microcirculatory ef""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,18,reference_content,"91 Strauch B, Patel MK, Rosen DJ, Mahadevia S, Brindzei N, Pilla AA. Pulsed magnetic field therapy increases tensile strength in a rat Achilles' tendon repair model. J. Hand Surg. Am. 31(7), 1131–1135","[766.0, 336.0, 1096.0, 459.0]",reference_item,0.85,"[""reference content label: 91 Strauch B, Patel MK, Rosen DJ, Mahadevia S, Brindzei N, P""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,19,reference_content,"92 Nakabayashi A, Kamei N, Sunagawa T et al. In vivo bioluminescence imaging of magnetically targeted bone marrow-derived mesenchymal stem cells in skeletal muscle injury model. J. Orthop. Res. 31(5),","[767.0, 467.0, 1097.0, 591.0]",reference_item,0.85,"[""reference content label: 92 Nakabayashi A, Kamei N, Sunagawa T et al. In vivo biolumi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,20,reference_content,"93 Tefft BJ, Gooden JY, Uthamaraj S et al. Magnetizable duplex steel stents enable endothelial cell capture. IEEE Trans. Magn. 49(1), 463–466 (2013).","[767.0, 599.0, 1095.0, 682.0]",reference_item,0.85,"[""reference content label: 93 Tefft BJ, Gooden JY, Uthamaraj S et al. Magnetizable dupl""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,21,reference_content,"94 Arendash GW. Transcranial electromagnetic treatment against Alzheimer's disease: why it has the potential to trump Alzheimer's disease drug development. J. Alzheimer's Dis. 32(2), 243–266 (2012).","[766.0, 690.0, 1095.0, 814.0]",reference_item,0.85,"[""reference content label: 94 Arendash GW. Transcranial electromagnetic treatment again""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,22,reference_content,"95 Kova ík P, Kremlá ková Z, Št pánek F. Investigation of radiofrequency induced release kinetics from magnetic hollow silica microspheres. Microporous Mesoporous Mater. 159, 119 (2012).","[765.0, 821.0, 1094.0, 924.0]",reference_item,0.85,"[""reference content label: 95 Kova \u00edk P, Kreml\u00e1 kov\u00e1 Z, \u0160t p\u00e1nek F. Investigation of ra""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,23,number,566,"[71.0, 1529.0, 110.0, 1550.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
14,24,footer,"Expert Rev. Mol. Diagn. 13(6), (2013)","[877.0, 1533.0, 1095.0, 1553.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 header THEMED ARTICLE | Nanotechnology & Single-Cell Analysis [138.0, 93.0, 796.0, 125.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
3 1 1 header Review [1030.0, 92.0, 1128.0, 124.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like short_fragment False False
4 1 2 header_image [140.0, 220.0, 318.0, 303.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False True
5 1 3 doc_title Contributions and future perspectives on the use of magnetic nanoparticles as diagnostic and therapeutic tools in the field of regenerative medicine [373.0, 215.0, 1019.0, 595.0] paper_title 0.8 ["page-1 zone title_zone: Contributions and future perspectives on the use of magnetic"] paper_title 0.8 frontmatter_main_zone support_like none True True
6 1 4 text Expert Rev. Mol. Diagn. 13(6), 553–566 (2013) [375.0, 633.0, 726.0, 657.0] structured_insert_candidate 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 frontmatter_main_zone support_like none False False
7 1 5 text Vítor E Santo $ ^{1,2} $, Márcia T Rodrigues $ ^{1,2} $ and Manuela E Gomes $ ^{*1,2} $ [115.0, 692.0, 353.0, 771.0] frontmatter_noise 0.7 ["keyword-like block: V\u00edtor E Santo $ ^{1,2} $, M\u00e1rcia T Rodrigues $ ^{1,2} $ and "] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
8 1 6 text ³B's Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806–909 Caldas das Taipas, Guimarães, Portugal ²ICV [115.0, 780.0, 352.0, 962.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: \u00b3B's Research Group \u2013 Biomaterials, Biodegradables and Biomi"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
9 1 7 abstract The current limitations of regenerative medicine strategies may be overcome through the use of magnetic nanoparticles (MNPs), a class of nanomaterial typically composed of magnetic elements that can b [373.0, 691.0, 1144.0, 971.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
10 1 8 text KEYWORDS: magnetic particles • magnetic responsive systems • regenerative medicine • stem cells • theranostics • tissue engineering [379.0, 987.0, 1121.0, 1028.0] frontmatter_noise 0.7 ["frontmatter noise text: KEYWORDS: magnetic particles \u2022 magnetic responsive systems \u2022"] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
11 1 9 text The goal of producing functional tissue substitutes using tissue engineering or other regenerative medicine strategies is challenged by the complexity of organ architectures $ [1] $. Some of the most [374.0, 1040.0, 753.0, 1449.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
12 1 10 text Nanoparticle research within regenerative medicine has been mainly focused on the development of delivery systems for biomolecules and reinforcing phase for polymeric matrices in 3D scaffolds for tiss [375.0, 1449.0, 753.0, 1497.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
13 1 11 text development of delivery systems for biomol- ecules and reinforcing phase for polymeric matrices in 3D scaffolds for tissue engineering [4]. For instance, hydroxyapatite nanocrystals have been used in [765.0, 1040.0, 1145.0, 1500.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
14 1 12 footer www.expert-reviews.com [115.0, 1532.0, 329.0, 1551.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
15 1 13 footer 10.1586/14737159.2013.819169 [377.0, 1532.0, 584.0, 1551.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
16 1 14 footer © 2013 Informa UK Ltd [693.0, 1532.0, 857.0, 1551.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
17 1 15 footer ISSN 1473-7159 [924.0, 1532.0, 1023.0, 1550.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like short_fragment False False
18 1 16 number 553 [1104.0, 1529.0, 1143.0, 1550.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
19 2 0 header Review [87.0, 93.0, 184.0, 123.0] noise 0.9 ["header label"] noise 0.9 frontmatter_side_zone support_like short_fragment False False
20 2 1 header Santo, Rodrigues & Gomes [206.0, 97.0, 459.0, 122.0] noise 0.9 ["header label"] noise 0.9 frontmatter_side_zone support_like none False False
21 2 2 text most promising inorganic nanomaterials being developed are metal, silica, dendrimers, ceramics and bioinorganic hybrids. Metallic nanoparticle contrast agents are typically applied for in vivo imaging [67.0, 176.0, 576.0, 297.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
22 2 3 text Magnetic nanoparticles (MNPs) have shown high potential for different biomedical applications as they present the ability to be manipulated under the influence of an external magnetic field [7]. The m [67.0, 297.0, 576.0, 656.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
23 2 4 text The ability of MNPs to be functionalized and concurrently respond to a magnetic field has made them a useful tool for theranostics [7]. MNPs can be coated/functionalized with organic or inorganic mate [67.0, 656.0, 577.0, 1209.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
24 2 5 text The association of MNPs with stem cells can be achieved by internalization of MNPs or through binding of these particles to cell surface markers such as integrins or through direct interaction with sp [67.0, 1208.0, 576.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
25 2 6 text for the design of multifunctional theranostic nanoparticles is the simultaneous incorporation of diagnostic elements and therapeutic motifs, specifically drug delivery ability [20]. d h ll h b d [589.0, 175.0, 1098.0, 248.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
26 2 7 text Once associated with cells, the MNPs can be incorporated into a 3D scaffold or hydrogel to obtain a tissue-engineered magnetic responsive system, enabling all the above mentioned functionalities. Alte [588.0, 248.0, 1099.0, 612.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
27 2 8 paragraph_title 3D magnetic constructs as the basis for a new generation of tissue-engineered substitutes [590.0, 632.0, 1012.0, 679.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: 3D magnetic constructs as the basis for a new generation of "] subsection_heading 0.6 frontmatter_side_zone heading_like none True True
28 2 9 text It is well known that the mechanical environment to which native tissues and cells are exposed significantly influences the homeostasis and regeneration processes. Therefore, techniques that directly [589.0, 680.0, 1099.0, 1161.0] affiliation 0.8 ["page-1 zone affiliation_zone: It is well known that the mechanical environment to which na"] affiliation 0.8 body_zone body_like none True True
29 2 10 text The labeling of stem cells with MNPs has been increasingly used to enable cell tracking and magnetic manipulation. The ability to noninvasively monitor cell trafficking in vivo in a longitudinal fashi [588.0, 1160.0, 1099.0, 1376.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
30 2 11 text The impact of magnetic stimulation on stem cell differentiation is still controversial [25]. Mechanical forces contribute to several cellular functions, including changes in gene expression, prolifera [588.0, 1376.0, 1099.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
31 2 12 number 554 [71.0, 1529.0, 110.0, 1549.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
32 2 13 footer Expert Rev. Mol. Diagn. 13(6), (2013) [877.0, 1532.0, 1095.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
33 3 0 header Use of magnetic nanoparticles as diagnostic & therapeutic tools [403.0, 99.0, 1007.0, 124.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
34 3 1 header Review [1031.0, 94.0, 1127.0, 122.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
35 3 2 text regulation, converting mechanical stimulus into biochemical signals [27]. The internalization of MNPs and consequent magnetic stimulation might be used to induce specific biomechanical signals and thu [114.0, 177.0, 451.0, 850.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
36 3 3 image [471.0, 179.0, 1137.0, 556.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone body_like empty True True
37 3 4 figure_title Figure 1. Potential strategies that can be used to augment the complexity and functionality of magnetic nanoparticles. The particles can be functionalized with antibodies for cell targeting and select [473.0, 573.0, 1136.0, 816.0] figure_caption 0.92 ["figure_title label: Figure 1. Potential strategies that can be used to augment t"] figure_caption 0.92 display_zone legend_like figure_number True True
38 3 5 text late the delivery of bioactive agents with an external stimulus can potentially improve the safety and efficiency of these agents $ [34–36] $. Table 1 summarizes some of the scaffolds/hydrogels incor [114.0, 850.0, 621.0, 944.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
39 3 6 text Zhao et al. introduced the designation of active scaffolds, which can offer the possibility of controlling the properties of the construct through an external stimulus as opposite to traditional porou [113.0, 945.0, 622.0, 1185.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
40 3 7 text Bock et al. proposed a promising new strategy based on the development of new magnetic scaffolds that could act as fixed ‘stations’ to attract growth factors and stem cells bound to MNPs [37]. This ap [112.0, 1186.0, 622.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
41 3 8 text of tumors [38,39]; however, the provided spatial accuracy and ther- apeutic efficacy is also of major interest for tissue engineering applications. The incorporation of SPMNs instead of the common MNP [634.0, 847.0, 1145.0, 1377.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
42 3 9 text The use of magnetic forces can also be directed towards the improvement of the efficiency of cell seeding. This step is a critical parameter on tissue engineering strategies as the success of the cons [635.0, 1377.0, 1146.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
43 3 10 footer www.expert-reviews.com [115.0, 1534.0, 327.0, 1554.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
44 3 11 number 555 [1103.0, 1529.0, 1142.0, 1550.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
45 4 0 header Review [88.0, 95.0, 182.0, 122.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
46 4 1 header Santo, Rodrigues & Gomes [206.0, 99.0, 459.0, 121.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
47 4 2 figure_title Table 1. Compilation of studies reporting the use of magnetic stimulation for the development of 3D constructs for tissue engineering and regenerative medicine. [74.0, 185.0, 1037.0, 237.0] table_caption 0.9 ["table prefix matched: Table 1. Compilation of studies reporting the use of magneti"] table_caption 0.9 display_zone table_caption_like table_number True True
48 4 3 table <table><tr><td colspan="6">constructs for tissue engineering and regenerative medicine.</td></tr><tr><td>Construct fabrication strategies</td><td>Approach</td><td>Magnetic role</td><td>Experimental se [74.0, 203.0, 1090.0, 1409.0] table_html 0.85 ["media label: table"] media_asset 0.85 body_zone body_like none True True
49 4 4 vision_footnote AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona [74.0, 1398.0, 1038.0, 1451.0] footnote 0.7 ["vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star"] footnote 0.7 body_zone body_like none True True
50 4 5 number 556 [71.0, 1529.0, 110.0, 1549.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
51 4 6 footer Expert Rev. Mol. Diagn. 13(6), (2013) [877.0, 1533.0, 1095.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
52 5 0 header Use of magnetic nanoparticles as diagnostic & therapeutic tools [403.0, 99.0, 1007.0, 124.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
53 5 1 header Review [1031.0, 93.0, 1128.0, 123.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
54 5 2 figure_title Table 1. Compilation of studies reporting the use of magnetic stimulation for the development of 3D constructs for tissue engineering and regenerative medicine (cont.). [120.0, 183.0, 1080.0, 234.0] table_caption 0.9 ["table prefix matched: Table 1. Compilation of studies reporting the use of magneti"] table_caption 0.9 display_zone table_caption_like table_number True True
55 5 3 table <table><tr><td>Construct fabrication strategies</td><td>Approach</td><td>Magnetic role</td><td>Experimental set up</td><td>Application</td><td>Ref.</td></tr><tr><td rowspan="3">Dispersion/impregnation [117.0, 191.0, 1137.0, 1122.0] table_html 0.85 ["media label: table"] media_asset 0.85 body_zone body_like none True True
56 5 4 vision_footnote AC: Alternating current; FF-DP: Ferrofluids coated with starch and functionalized with phosphate groups; FF-DXS: Ferrofluids coated with dextransulfate and functionalized with sodium sulfate functiona [118.0, 1129.0, 1082.0, 1181.0] footnote 0.7 ["vision_footnote label: AC: Alternating current; FF-DP: Ferrofluids coated with star"] footnote 0.7 body_zone body_like none True True
57 5 5 text of the scaffolds and insufficient migration of the cells into the scaffolds lead to a shortage of initially seeded cells, resulting in less significant outcomes. In this context, the functionalization [112.0, 1208.0, 623.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
58 5 6 text the formulations in which the magnetic force was applied, thus demonstrating the potential of this novel design for tissue engi- neering purposes. Depending on the scaffold, an improvement on cell see [634.0, 1207.0, 1145.0, 1424.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
59 5 7 text Other methods in which the application of magnetic fields can be useful are the bottom-up scaffold fabrication techniques. The assembly of building blocks such as cell-encapsulating microscale [635.0, 1424.0, 1145.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
60 5 8 footer www.expert-reviews.com [115.0, 1534.0, 328.0, 1554.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
61 5 9 number 557 [1103.0, 1528.0, 1141.0, 1550.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
62 6 0 header Review [87.0, 94.0, 183.0, 123.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
63 6 1 header Santo, Rodrigues & Gomes [206.0, 98.0, 458.0, 121.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
64 6 2 text hydrogels mimics the structure of native tissues, typically composed by repeating functional units [43]. Despite the promising opportunities provided by this approach, the control over this assembly i [67.0, 177.0, 577.0, 848.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
65 6 3 text A recent report by Tasoglu et al. has shown that the magnetic assembly can be provided in the absence of MNPs [43]. The results demonstrate that PEG hydrogels that were exposed to UV radiation for lon [69.0, 849.0, 577.0, 898.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
66 6 4 text demonstrate that PEG hydrogels that were exposed to UV radia- tion for longer periods traveled towards the magnets with higher velocity. The exposure to UV induces the formation of free radi- cals, wh [588.0, 176.0, 1101.0, 849.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
67 6 5 text The fabrication of magnetically responsive hydrogels crosslinked with paramagnetic ions has also been pursued [48]. Typically, a [589.0, 848.0, 1099.0, 899.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
68 6 6 image [77.0, 925.0, 1086.0, 1362.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone body_like empty True True
69 6 7 figure_title Figure 2. Sequential magnetic fusion for the formation of a cartilage construct. (A) Sixteen spheroid aggregates were formed through the use of a network of magnetic tips, which were then placed in co [80.0, 1386.0, 1080.0, 1489.0] figure_caption 0.92 ["figure_title label: Figure 2. Sequential magnetic fusion for the formation of a "] figure_caption 0.92 display_zone legend_like figure_number True True
70 6 8 number 558 [71.0, 1529.0, 110.0, 1549.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
71 6 9 footer Expert Rev. Mol. Diagn. 13(6), (2013) [877.0, 1533.0, 1095.0, 1552.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
72 7 0 header Use of magnetic nanoparticles as diagnostic & therapeutic tools [402.0, 99.0, 1007.0, 124.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
73 7 1 header Review [1031.0, 93.0, 1128.0, 123.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
74 7 2 text correlation between the concentration of the paramagnetic ions and magnetic field gradient can be achieved. In an externally applied magnetic field, the paramagnetic hydrogel spheres assemble into ord [111.0, 176.0, 622.0, 345.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
75 7 3 text Another promising tissue engineering methodology where a 3D tissue is constructed without artificial scaffolds is the magnetically induced cell sheet technology (TABLE 1). MNPs can label specific cell [112.0, 344.0, 622.0, 1018.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
76 7 4 text The use of external magnetic fields present some limitations, namely the targeting challenge of deep tissues as the targeting efficiency depends on the distance between the magnet and the tissue of in [112.0, 1017.0, 623.0, 1400.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
77 7 5 text effect of labeling stem cells with MNPs. They induce mechani- cal stimulation through different mechanisms, namely magnetic twisting, mechanosensitive ion channel activation, targeted ion channel acti [633.0, 176.0, 1145.0, 320.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
78 7 6 text Furthermore, the mechanical stimulation induced by magnetic forces has also been shown to produce significant effects on cells, increasing their metabolic activity during the stimulation period [55]. [113.0, 1401.0, 623.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
79 7 7 text pi p y general, no adverse effects are found. Wu et al. demonstrated an enhancement of mitochondrial activity and expression of bone-related genes in human bone marrow MSCs adhered to iron-containing [633.0, 320.0, 1145.0, 825.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
80 7 8 text The feasibility of mechanical stimulation induced by magnetic forces has been shown to promote osteogenic and chondrogenic differentiation of MSCs [28,29] and to promote the organization of endothelia [634.0, 824.0, 1144.0, 997.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
81 7 9 paragraph_title Imaging & biosensing functionalities in tissue-engineered substitutes [635.0, 1015.0, 1062.0, 1064.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Imaging & biosensing functionalities in tissue-engineered su"] subsection_heading 0.6 body_zone heading_like none True True
82 7 10 text Major achievements in tissue engineering and regenerative medicine therapies are expected from a major challenge in nanomedicine, which consists of integrating selective targeting, imaging and directe [633.0, 1065.0, 1145.0, 1500.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
83 7 11 footer www.expert-reviews.com [114.0, 1534.0, 328.0, 1554.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
84 7 12 number 559 [1103.0, 1529.0, 1142.0, 1550.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
85 8 0 header Review [88.0, 94.0, 182.0, 123.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
86 8 1 header Santo, Rodrigues & Gomes [207.0, 98.0, 458.0, 121.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
87 8 2 image [80.0, 184.0, 552.0, 1049.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone body_like empty True True
88 8 3 figure_title Figure 3. Endothelial cell organization in magnetic nanoparticle–alginate and alginate constructs. After the seeding into the MNP or alginate scaffold, the endothelial cells were exposed to an alterna [79.0, 1076.0, 568.0, 1337.0] figure_caption 0.92 ["figure_title label: Figure 3. Endothelial cell organization in magnetic nanopart"] figure_caption 0.92 display_zone legend_like figure_number True True
89 8 4 text to lesion tissue [60], optical detectability and therapeutic delivery, as mentioned before. [69.0, 1353.0, 574.0, 1400.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
90 8 5 text The application of MNPs in MRI-based technologies is envisioned to improve spatial resolution and soft tissue contrast at a nanoscale level, while simultaneously imaging tissue anatomy, physiology and [68.0, 1401.0, 577.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
91 8 6 text biomaterial systems. The detectability of MRI can be signifi- cantly improved by the preferential accumulation of MNP contrast agents if the targeting ligands, such as a protein or an antibody, are at [589.0, 175.0, 1099.0, 585.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
92 8 7 text SPMNs were described to be preferred to gadolinium chelates for cell labeling because they provide high signal contrasts in T2/T2*-weighted image sequences, are nontoxic and biodegradable [61]. [589.0, 585.0, 1098.0, 680.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
93 8 8 text In the particular field of tissue engineering, MNPs hold great promise as a detection method for cell selection, cell sorting, spatial control of target cells and cell aggregation and adherence proper [589.0, 681.0, 1099.0, 849.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
94 8 9 text Tracking of implanted cells in regenerative medicine strategies is critical to evaluate cell migration and cellular functions, and to help guide treatment for maximized therapeutic effect [62]. Magnet [590.0, 849.0, 1098.0, 1185.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
95 8 10 text The work of Bulte et al. was pioneer on the development of magnetodendrimers for labeling of stem and progenitor cells through a nonspecific membrane adsorption process with a subsequent intracellular [590.0, 1185.0, 1098.0, 1352.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
96 8 11 text The group of Chien Ho has also explored the possibility of using MRI to noninvasively monitor individual immune cells, primarily macrophages in vivo, after heart and lung transplantation $ [65] $. Th [589.0, 1353.0, 1099.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
97 8 12 number 560 [72.0, 1529.0, 110.0, 1549.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
98 8 13 footer Expert Rev. Mol. Diagn. 13(6), (2013) [877.0, 1532.0, 1095.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
99 9 0 header Use of magnetic nanoparticles as diagnostic & therapeutic tools [403.0, 99.0, 1007.0, 124.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
100 9 1 header Review [1031.0, 94.0, 1128.0, 122.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
101 9 2 text to complement biopsy is highly desirable. This technique may also be applied to assess the inflammatory response to implanted constructs in tissue engineering strategies, allowing the in situ monitori [112.0, 177.0, 622.0, 272.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
102 9 3 text Several protocols have already been described for in vivo tracking of human skeletal muscle cells [66]. Other protocols use cells as a circulating vehicle; for instance, erythrocytes have been explore [112.0, 273.0, 622.0, 631.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
103 9 4 text Other studies on MSC tracking in limb ischemia revealed MNPs' low toxicity and MSC detection after transplantation $ [68] $. In a rabbit osteochondral model, alginate-incorporated MNPs guided by exte [113.0, 632.0, 622.0, 849.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
104 9 5 text Some pioneer studies on the design techniques of these multimodal nanoparticles have already been published. Zhu et al. developed probes combining magnetic, fluorescence and thermoresponsive features [112.0, 848.0, 623.0, 1211.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
105 9 6 paragraph_title Biosensing [115.0, 1233.0, 216.0, 1255.0] sub_subsection_heading 0.6 ["unnumbered paragraph_title, inferred level sub_subsection_heading: Biosensing"] sub_subsection_heading 0.6 body_zone body_like short_fragment True True
106 9 7 text The rapid and sensitive detection of molecular targets such as genetic material, proteins, enzymes, cytokines, growth factors, pathogens and metabolic byproducts secreted by cells is a major point in [112.0, 1256.0, 622.0, 1377.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
107 9 8 text The detection and measurement of biomolecules in the culture medium where cell-laden tissue engineering systems are cultured gathers relevant information on in vitro cell behavior and thus of the tiss [113.0, 1377.0, 623.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
108 9 9 text methodologies. MNPs are also envisioned to play a role in the detection, labeling and selective elimination of pathogens poten- tially present in a culture medium or targeted antibacterial ther- apy t [634.0, 176.0, 1144.0, 369.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
109 9 10 text By incorporating advanced features, the detectability and applicability of MNPs have been dramatically expanded. Nevertheless, the location, distribution and long-term viability of tagged cells for cl [634.0, 368.0, 1145.0, 512.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
110 9 11 text Preclinical assays for cardiac applications are already being performed. Subcutaneous sensors were implanted in rodents for noninvasive measuring cardiac-specific biomarker levels in an attempt to pre [633.0, 513.0, 1145.0, 682.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
111 9 12 paragraph_title Remote-controlled therapies [636.0, 705.0, 893.0, 726.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Remote-controlled therapies"] subsection_heading 0.6 body_zone body_like none True True
112 9 13 text Magnetic field therapies, often referred as pulsed electromagnetic field (PEMF) therapies, are already applied in clinical practice to promote bone healing in delayed unions and nonunions $ [71] $ wi [634.0, 729.0, 1144.0, 920.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
113 9 14 text Pilot clinical trials also indicate the beneficial effects of PEMF on pain relief $ [73,75,76] $, in particular the rapid impact on pain reduction from early knee osteoarthritis $ [75] $ or osteonec [634.0, 920.0, 1144.0, 1064.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
114 9 15 text One of the reported effects of this therapy includes the enhancement of metabolic activity of chondrocytes [77–79] and the prevention of the catabolic effects of inflammation [80–84] caused by osteoar [634.0, 1065.0, 1145.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
115 9 16 footer www.expert-reviews.com [115.0, 1534.0, 328.0, 1554.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
116 9 17 number 561 [1103.0, 1529.0, 1140.0, 1550.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
117 10 0 header Review Santo, Rodrigues & Gomes [86.0, 96.0, 458.0, 122.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
118 10 1 image [78.0, 186.0, 1090.0, 421.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone body_like empty True True
119 10 2 figure_title Figure 4. Magnet-scaffold configurations suggested by Russo et al. (A) External permanent magnetic ring (EM); (B) implanted permanent magnetic pins (PM); (C) implanted stainless steel pins in the fiel [79.0, 439.0, 1065.0, 561.0] figure_caption 0.92 ["figure_title label: Figure 4. Magnet-scaffold configurations suggested by Russo "] figure_caption 0.92 display_zone legend_like figure_number True True
120 10 3 text growth factors, including bone morphogenetic proteins and TGF $ [87,88] $. Angiogenesis $ [89,90] $ and mechanical properties $ [91] $ were also reported to be enhanced post-therapy. [67.0, 584.0, 576.0, 656.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
121 10 4 text Despite the fact that remote-controlled therapies are poorly explored in the fields of cell and tissue engineering, increasing focus has been devoted to explore the remote control applications, includ [68.0, 657.0, 576.0, 1233.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
122 10 5 text PEMF therapies have been already US FDA approved for several pathologies including nonunion bone fractures and arthritic pain, but studies directed to tissue engineering and regenerative medicine stra [67.0, 1233.0, 577.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
123 10 6 text would stimulate implantable scaffolds. The incorporation of MNPs in the scaffolds in combination with PEMF stimulation would likely result in a synergistic therapeutic effect. In the case of multifunc [588.0, 583.0, 1099.0, 945.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
124 10 7 text Selective control of cell function by applying time-varying magnetic fields has added a new, exciting dimension to biology and medicine. The ability to remotely control cell or construct fate locally [588.0, 944.0, 1099.0, 1138.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
125 10 8 paragraph_title Expert commentary [591.0, 1161.0, 779.0, 1183.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Expert commentary"] subsection_heading 0.6 body_zone heading_like short_fragment True True
126 10 9 text Besides sorting and isolation abilities, MNPs may also be used as pulsatile delivery systems for the release of selected growth factors. Magnetism is acknowledged as an advantageous physical stimulus [588.0, 1185.0, 1100.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
127 10 10 number 562 [72.0, 1529.0, 110.0, 1549.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
128 10 11 footer Expert Rev. Mol. Diagn. 13(6), (2013) [877.0, 1532.0, 1095.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
129 11 0 header Use of magnetic nanoparticles as diagnostic & therapeutic tools [403.0, 99.0, 1006.0, 124.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
130 11 1 header Review [1032.0, 94.0, 1127.0, 122.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
131 11 2 text Probably the most challenging and innovative aspects of magnetic-based approaches consist of the integration of the theranostic tools provided by the MNPs into a 3D tissue-engineered construct as well [114.0, 177.0, 621.0, 323.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
132 11 3 paragraph_title Five-year view [115.0, 345.0, 253.0, 367.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Five-year view"] subsection_heading 0.6 body_zone heading_like short_fragment True True
133 11 4 text The increased number of literature reports shows a clear tendency for a significant increase in research focusing on magnetic responsive systems and their potential in the regenerative medicine field, [113.0, 368.0, 621.0, 464.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
134 11 5 text To fabricate 3D magnetic responsive tissue-engineered constructs with precisely controlled architectures, the ability to assemble cell-laden microscale magnetic hydrogels (M-gels) should be further ex [114.0, 465.0, 621.0, 607.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
135 11 6 text Research in this field is also expected to further explore the ability of magnetic systems to promote the release of relevant molecules through a magnetic switch on/off and their role on stem cell dev [115.0, 609.0, 622.0, 658.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
136 11 7 text molecules through a magnetic switch on/off and their role on stem cell development as well as the ability for the ex vivo stimulation of implanted devices. [636.0, 177.0, 1143.0, 247.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
137 11 8 text Finally, a great deal of attention is also expected to be directed to the clarification of the long-term fate of embedded MNPs before considering the clinical application of magnetic tissue-engineered [636.0, 249.0, 1144.0, 343.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
138 11 9 text In summary, in upcoming years, several advances are expected that will revolutionize the field as they hold the potential to overcome main obstacles to the routine use of tissue engineering therapies [636.0, 345.0, 1144.0, 443.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
139 11 10 paragraph_title Financial & competing interests disclosure [636.0, 465.0, 986.0, 487.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Financial & competing interests disclosure"] subsection_heading 0.6 body_zone body_like none True True
140 11 11 text The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in [636.0, 491.0, 1145.0, 632.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
141 11 12 text No writing assistance was utilized in the production of this manuscript. [653.0, 634.0, 1141.0, 657.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
142 11 13 paragraph_title Key issues [121.0, 695.0, 225.0, 720.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Key issues"] subsection_heading 0.6 body_zone heading_like short_fragment True True
143 11 14 text • Magnetic nanoparticles (MNPs) allow the development of magnetic responsive tissue-engineered systems that may enable pulsatile delivery of growth factors while simultaneously allowing magnetic stimu [120.0, 730.0, 1107.0, 794.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
144 11 15 text • Magnetic responsive tissue-engineered systems may be obtained by direct incorporation of the MNPs into a 3D scaffold or hydrogel or by association of MNPs with stem cells that are subsequently seede [122.0, 797.0, 1129.0, 840.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
145 11 16 text • Magnetic responsive systems may allow simultaneous diagnostic and therapeutic functionalities; therapeutic functionalities include the possibility to enhance stem cells response, tailoring their loc [120.0, 843.0, 1134.0, 993.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
146 11 17 paragraph_title References [116.0, 1041.0, 220.0, 1062.0] reference_heading 0.9 ["references heading: References"] reference_heading 0.9 reference_zone heading_like short_fragment True True
147 11 18 reference_content Papers of special note have been highlighted as: • of interest [116.0, 1065.0, 422.0, 1106.0] reference_item 0.85 ["reference content label: Papers of special note have been highlighted as:\n\u2022 of intere"] reference_item 0.85 reference_zone unknown_like none True True
148 11 19 reference_content •• of considerable interest [117.0, 1105.0, 286.0, 1124.0] reference_item 0.85 ["reference content label: \u2022\u2022 of considerable interest"] reference_item 0.85 reference_zone unknown_like none True True
149 11 20 reference_content 1 Santo VE, Gomes ME, Mano JF, Reis RL. From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering. Nanomedicine (Lo [116.0, 1130.0, 435.0, 1255.0] reference_item 0.85 ["reference content label: 1 Santo VE, Gomes ME, Mano JF, Reis RL. From nano- to macro-"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
150 11 21 reference_content 2 Li Y, Huang G, Zhang X et al. Magnetic hydrogels and their potential biomedical applications. Adv. Funct. Mater. 23(6), 660–672 (2013). [115.0, 1263.0, 426.0, 1345.0] reference_item 0.85 ["reference content label: 2 Li Y, Huang G, Zhang X et al. Magnetic hydrogels and their"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
151 11 22 reference_content 3 Santo VE, Duarte AR, Popa EG, Gomes ME, Mano JF, Reis RL. Enhancement of osteogenic differentiation of human adipose derived stem cells by the controlled release of platelet lysates from hybrid scaf [114.0, 1353.0, 441.0, 1477.0] reference_item 0.85 ["reference content label: 3 Santo VE, Duarte AR, Popa EG, Gomes ME, Mano JF, Reis RL. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
152 11 23 reference_content foaming. J. Control. Release 162(1), 19–27 (2012). [496.0, 1040.0, 784.0, 1081.0] reference_item 0.85 ["reference content label: foaming. J. Control. Release 162(1), 19\u201327 (2012)."] reference_item 0.85 reference_zone unknown_like none True True
153 11 24 reference_content 4 Engel E, Michiardi A, Navarro M, Lacroix D, Planell JA. Nanotechnology in regenerative medicine: the materials side. Trends Biotechnol. 26(1), 39–47 (2008). [465.0, 1090.0, 792.0, 1172.0] reference_item 0.85 ["reference content label: 4 Engel E, Michiardi A, Navarro M, Lacroix D, Planell JA. Na"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
154 11 25 reference_content 5 Fleischer S, Dvir T. Tissue engineering on the nanoscale: lessons from the heart. Curr. Opin. Biotechnol. 24, 1–8 (2012) [466.0, 1180.0, 790.0, 1242.0] reference_item 0.85 ["reference content label: 5 Fleischer S, Dvir T. Tissue engineering on the nanoscale: "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
155 11 26 reference_content 6 Sekhon BS, Kamboj SR. Inorganic nanomedicine—part 1. Nanomedicine 6(4), 516–522 (2010). [465.0, 1249.0, 785.0, 1310.0] reference_item 0.85 ["reference content label: 6 Sekhon BS, Kamboj SR. Inorganic nanomedicine\u2014part 1. Nanom"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
156 11 27 reference_content 7 Shubayev VI, Pisanic TR 2nd, Jin S. Magnetic nanoparticles for theragnostics. Adv. Drug Deliv. Rev. 61(6), 467–477 (2009). [464.0, 1317.0, 779.0, 1399.0] reference_item 0.85 ["reference content label: 7 Shubayev VI, Pisanic TR 2nd, Jin S. Magnetic nanoparticles"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
157 11 28 reference_content 8 Singamaneni S, Bliznyuk VN, Binek C, Tsymbal EY. Magnetic nanoparticles: recent advances in synthesis, self-assembly [465.0, 1408.0, 783.0, 1469.0] reference_item 0.85 ["reference content label: 8 Singamaneni S, Bliznyuk VN, Binek C, Tsymbal EY. Magnetic "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
158 11 29 reference_content and applications. J. Mater. Chem. 21(42), 16819–16845 (2011). [844.0, 1040.0, 1127.0, 1081.0] reference_item 0.85 ["reference content label: and applications. J. Mater. Chem. 21(42), 16819\u201316845 (2011)"] reference_item 0.85 reference_zone unknown_like none True True
159 11 30 reference_content 9 Bonnemain B. Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review. J. Drug Target. 6(3), 167–174 (1998). [813.0, 1090.0, 1140.0, 1193.0] reference_item 0.85 ["reference content label: 9 Bonnemain B. Superparamagnetic agents in magnetic resonanc"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
160 11 31 reference_content 10 Zhu H, Tao J, Wang W et al. Magnetic, fluorescent, and thermo-responsive Fe(3)O(4)/rare earth incorporated poly(St-NIPAM) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance [813.0, 1201.0, 1136.0, 1345.0] reference_item 0.85 ["reference content label: 10 Zhu H, Tao J, Wang W et al. Magnetic, fluorescent, and th"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
161 11 32 reference_content - Describes a multimodal imaging probe combining magnetic, fluorescent and thermoresponsive properties. [813.0, 1354.0, 1121.0, 1419.0] reference_item 0.85 ["reference content label: - Describes a multimodal imaging probe combining magnetic, f"] reference_item 0.85 reference_zone unknown_like none True True
162 11 33 reference_content 11 Daniel-Da-Silva AL, Fateixa S, Guiomar AJ et al. Biofunctionalized magnetic hydrogel nanospheres of magnetite and [813.0, 1426.0, 1123.0, 1488.0] reference_item 0.85 ["reference content label: 11 Daniel-Da-Silva AL, Fateixa S, Guiomar AJ et al. Biofunct"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
163 11 34 footer www.expert-reviews.com [115.0, 1535.0, 327.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 tail_nonref_hold_zone unknown_like none False False
164 11 35 number 563 [1103.0, 1529.0, 1141.0, 1550.0] noise 0.9 ["page number label"] noise 0.9 tail_nonref_hold_zone unknown_like short_fragment False False
165 12 0 header Review [88.0, 94.0, 183.0, 122.0] noise 0.9 ["header label"] noise 0.9 unknown_like short_fragment False False
166 12 1 header Santo, Rodrigues & Gomes [207.0, 98.0, 458.0, 121.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
167 12 2 reference_content κ-carrageenan. Nanotechnology 20(35), 355602 (2009). [102.0, 177.0, 368.0, 217.0] reference_item 0.85 ["reference content label: \u03ba-carrageenan. Nanotechnology 20(35), 355602 (2009)."] reference_item 0.85 reference_zone unknown_like none True True
168 12 3 reference_content 12 Santo VE, Gomes ME, Mano JF, Reis RL. Chitosan-chondroitin sulphate nanoparticles for controlled delivery of platelet lysates in bone regenerative medicine. J. Tissue Eng. Regen. Med. 6(Suppl. 3), [73.0, 224.0, 401.0, 348.0] reference_item 0.85 ["reference content label: 12 Santo VE, Gomes ME, Mano JF, Reis RL. Chitosan-chondroiti"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
169 12 4 reference_content 13 Balmayor ER, Pashkuleva I, Frias AM, Azevedo HS, Reis RL. Synthesis and functionalization of superparamagnetic poly-e-caprolactone microparticles for the selective isolation of subpopulations of hu [72.0, 356.0, 399.0, 501.0] reference_item 0.85 ["reference content label: 13 Balmayor ER, Pashkuleva I, Frias AM, Azevedo HS, Reis RL."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
170 12 5 reference_content 14 Hsiao JK, Tai MF, Chu HH et al. Magnetic nanoparticle labeling of mesenchymal stem cells without transfection agent: cellular behavior and capability of detection with clinical 1.5 T magnetic reson [73.0, 510.0, 395.0, 656.0] reference_item 0.85 ["reference content label: 14 Hsiao JK, Tai MF, Chu HH et al. Magnetic nanoparticle lab"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
171 12 6 reference_content 15 Markides H, Rotherham M, El Haj AJ. Biocompatibility and toxicity of magnetic nanoparticles in regenerative medicine. J. Nanomater. 2012, 1–11 (2012). [74.0, 663.0, 388.0, 746.0] reference_item 0.85 ["reference content label: 15 Markides H, Rotherham M, El Haj AJ. Biocompatibility and "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
172 12 7 reference_content 16 Perea H, Aigner J, Heverhagen JT, Hopfner U, Wintermantel E. Vascular tissue engineering with magnetic nanoparticles: seeing deeper. J. Tissue Eng. Regen. Med. 1(4), 318–321 (2007). [75.0, 753.0, 396.0, 856.0] reference_item 0.85 ["reference content label: 16 Perea H, Aigner J, Heverhagen JT, Hopfner U, Wintermantel"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
173 12 8 reference_content 17 Samberg ME, Loboa EG, Oldenburg SJ, Monteiro-Riviere NA. Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity. Nanomedicine (Lond.) 7(8), 1197–1209 (2012). [74.0, 864.0, 393.0, 967.0] reference_item 0.85 ["reference content label: 17 Samberg ME, Loboa EG, Oldenburg SJ, Monteiro-Riviere NA. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
174 12 9 reference_content 18 Wimpenny I, Markides H, El Haj AJ. Orthopaedic applications of nanoparticle-based stem cell therapies. Stem Cell Res. Ther. 3(2), 13 (2012). [73.0, 975.0, 388.0, 1056.0] reference_item 0.85 ["reference content label: 18 Wimpenny I, Markides H, El Haj AJ. Orthopaedic applicatio"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
175 12 10 reference_content 19 Xu F, Wu CA, Rengarajan V et al. Three-dimensional magnetic assembly of microscale hydrogels. Adv. Mater. Weinheim 23(37), 4254–4260 (2011). [74.0, 1065.0, 385.0, 1147.0] reference_item 0.85 ["reference content label: 19 Xu F, Wu CA, Rengarajan V et al. Three-dimensional magnet"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
176 12 11 reference_content 20 Lee JM, Kim BS, Lee H, Im GI. In vivo tracking of mesenchymal stem cells using fluorescent nanoparticles in an osteochondral repair model. Mol. Ther. 20(7), 1434–1442 (2012). [73.0, 1156.0, 390.0, 1257.0] reference_item 0.85 ["reference content label: 20 Lee JM, Kim BS, Lee H, Im GI. In vivo tracking of mesench"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
177 12 12 reference_content 21 Hughes S, Dobson J, El Haj AJ. Magnetic targeting of mechanosensors in bone cells for tissue engineering applications. J. Biomech. 40(Suppl. 1), S96–104 (2007). [73.0, 1266.0, 391.0, 1349.0] reference_item 0.85 ["reference content label: 21 Hughes S, Dobson J, El Haj AJ. Magnetic targeting of mech"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
178 12 13 reference_content 22 Kanczler JM, Sura HS, Magnay J et al. Controlled differentiation of human bone marrow stromal cells using magnetic nanoparticle technology. Tissue Eng. Part A 16(10), 3241–3250 (2010). [71.0, 1356.0, 397.0, 1459.0] reference_item 0.85 ["reference content label: 22 Kanczler JM, Sura HS, Magnay J et al. Controlled differen"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
179 12 14 reference_content 23 Tseng P, Judy JW, Di Carlo D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Nat. Methods 9(11), 1113–1119 (2012). [419.0, 177.0, 731.0, 279.0] reference_item 0.85 ["reference content label: 23 Tseng P, Judy JW, Di Carlo D. Magnetic nanoparticle-media"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
180 12 15 reference_content 24 Villa C, Erratico S, Razini P et al. Stem cell tracking by nanotechnologies. Int. J. Mol. Sci. 11(3), 1070–1081 (2010). [420.0, 287.0, 748.0, 349.0] reference_item 0.85 ["reference content label: 24 Villa C, Erratico S, Razini P et al. Stem cell tracking b"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
181 12 16 reference_content 25 Fayol D, Frasca G, Le Visage C, Gazeau F, Luciani N, Wilhelm C. Use of magnetic forces to promote stem cell aggregation during differentiation, and cartilage tissue modeling. Adv. Mater. Weinheim 2 [419.0, 357.0, 742.0, 480.0] reference_item 0.85 ["reference content label: 25 Fayol D, Frasca G, Le Visage C, Gazeau F, Luciani N, Wilh"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
182 12 17 reference_content • Description of a sequential and modular process for the magnetically induced assembly of large constructs without core necrosis. [419.0, 490.0, 740.0, 574.0] reference_item 0.85 ["reference content label: \u2022 Description of a sequential and modular process for the ma"] reference_item 0.85 reference_zone unknown_like none True True
183 12 18 reference_content 26 Grogan SP, Pauli C, Chen P et al. In situ tissue engineering using magnetically guided three-dimensional cell patterning. Tissue Eng. Part C. Methods 18(7), 496–506 (2012). [420.0, 582.0, 733.0, 685.0] reference_item 0.85 ["reference content label: 26 Grogan SP, Pauli C, Chen P et al. In situ tissue engineer"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
184 12 19 reference_content 27 Sniadecki NJ, Anguelouch A, Yang MT et al. Magnetic microposts as an approach to apply forces to living cells. Proc. Natl Acad. Sci. USA 104(37), 14553–14558 (2007). [419.0, 694.0, 736.0, 797.0] reference_item 0.85 ["reference content label: 27 Sniadecki NJ, Anguelouch A, Yang MT et al. Magnetic micro"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
185 12 20 reference_content 28 Bancroft GN, Sikavitsas VI, Mikos AG. Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng. 9(3), 549–554 (2003). [420.0, 806.0, 722.0, 908.0] reference_item 0.85 ["reference content label: 28 Bancroft GN, Sikavitsas VI, Mikos AG. Design of a flow pe"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
186 12 21 reference_content 29 Bancroft GN, Sikavitsas VI, van den Dolder J et al. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc. Natl A [419.0, 917.0, 726.0, 1061.0] reference_item 0.85 ["reference content label: 29 Bancroft GN, Sikavitsas VI, van den Dolder J et al. Fluid"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
187 12 22 reference_content 30 Sun S, Anders S, Hamann HF et al. Polymer mediated self-assembly of magnetic nanoparticles. J. Am. Chem. Soc. 124(12), 2884–2885 (2002). [420.0, 1070.0, 738.0, 1151.0] reference_item 0.85 ["reference content label: 30 Sun S, Anders S, Hamann HF et al. Polymer mediated self-a"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
188 12 23 reference_content 31 Hu S-H, Liu T-Y, Tsai C-H, Chen S-Y. Preparation and characterization of magnetic ferroscaffolds for tissue engineering. J. Magn. Magn. Mater. 310(2, Pt 3), 2871–2873 (2007). [420.0, 1160.0, 739.0, 1262.0] reference_item 0.85 ["reference content label: 31 Hu S-H, Liu T-Y, Tsai C-H, Chen S-Y. Preparation and char"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
189 12 24 reference_content 32 Paulino AT, Pereira AG, Fajardo AR et al. Natural polymer-based magnetic hydrogels: potential vectors for remote-controlled drug release. Carbohydr. Polym. 90(3), 1216–1225 (2012). [420.0, 1271.0, 747.0, 1373.0] reference_item 0.85 ["reference content label: 32 Paulino AT, Pereira AG, Fajardo AR et al. Natural polymer"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
190 12 25 reference_content 33 Skaat H, Ziv-Polat O, Shahar A, Last D, Mardor Y, Margel S. Magnetic scaffolds enriched with bioactive nanoparticles for tissue engineering. Adv. Healthc. Mater. 1(2), 168–171 (2012). [420.0, 1382.0, 730.0, 1484.0] reference_item 0.85 ["reference content label: 33 Skaat H, Ziv-Polat O, Shahar A, Last D, Mardor Y, Margel "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
191 12 26 reference_content 34 Zhao X, Kim J, Cezar CA et al. Active scaffolds for on-demand drug and cell delivery. Proc. Natl Acad. Sci. USA 108(1), 67–72 (2011). [767.0, 174.0, 1093.0, 256.0] reference_item 0.85 ["reference content label: 34 Zhao X, Kim J, Cezar CA et al. Active scaffolds for on-de"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
192 12 27 reference_content Key work on the development of magnetic constructs for tissue engineering applications. [767.0, 265.0, 1095.0, 330.0] reference_item 0.85 ["reference content label: Key work on the development of magnetic constructs for tissu"] reference_item 0.85 reference_zone unknown_like none True True
193 12 28 reference_content 35 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release strategies for bone, cartilage, and osteochondral engineering-part I: recapitulation of native tissue healing and variables for the design o [767.0, 337.0, 1086.0, 480.0] reference_item 0.85 ["reference content label: 35 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
194 12 29 reference_content 36 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release strategies for bone, cartilage, and osteochondral engineering—part II: challenges on the evolution from single to multiple bioactive factor [767.0, 490.0, 1088.0, 633.0] reference_item 0.85 ["reference content label: 36 Santo VE, Gomes ME, Mano JF, Reis RL. Controlled release "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
195 12 30 reference_content 37 Bock N, Riminucci A, Dionigi C et al. A novel route in bone tissue engineering: magnetic biomimetic scaffolds. Acta Biomater. 6(3), 786–796 (2010). [767.0, 642.0, 1078.0, 725.0] reference_item 0.85 ["reference content label: 37 Bock N, Riminucci A, Dionigi C et al. A novel route in bo"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
196 12 31 reference_content 38 Kobayashi T. Cancer hyperthermia using magnetic nanoparticles. Biotechnol. J. 6(11), 1342–1347 (2011). [767.0, 734.0, 1080.0, 794.0] reference_item 0.85 ["reference content label: 38 Kobayashi T. Cancer hyperthermia using magnetic nanoparti"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
197 12 32 reference_content 39 Wang L, Dong J, Ouyang W, Wang X, Tang J. Anticancer effect and feasibility study of hyperthermia treatment of pancreatic cancer using magnetic nanoparticles. Oncol. Rep. 27(3), 719–726 (2012). [766.0, 802.0, 1088.0, 925.0] reference_item 0.85 ["reference content label: 39 Wang L, Dong J, Ouyang W, Wang X, Tang J. Anticancer effe"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
198 12 33 reference_content 40 Campbell SB, Patenaude M, Hoare T. Injectable superparamagnets: highly elastic and degradable poly (N-isopropylacrylamide)-superparamagnetic iron oxide nanoparticle (SPION) composite hydrogels. Bio [766.0, 934.0, 1091.0, 1079.0] reference_item 0.85 ["reference content label: 40 Campbell SB, Patenaude M, Hoare T. Injectable superparama"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
199 12 34 reference_content 41 Shimizu K, Ito A, Honda H. Enhanced cell-seeding into 3D porous scaffolds by use of magnetite nanoparticles. J. Biomed. Mater. Res. Part B Appl. Biomater. 77(2), 265–272 (2006). [767.0, 1087.0, 1084.0, 1189.0] reference_item 0.85 ["reference content label: 41 Shimizu K, Ito A, Honda H. Enhanced cell-seeding into 3D "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
200 12 35 reference_content 42 Thevenot P, Sohaebuddin S, Poudyal N, Liu JP, Tang L. Magnetic Nanoparticles to Enhance Cell Seeding and Distribution in Tissue Engineering Scaffolds. Proc. IEEE Conf. Nanotechnol. 2008, 646–649 (2 [767.0, 1197.0, 1092.0, 1301.0] reference_item 0.85 ["reference content label: 42 Thevenot P, Sohaebuddin S, Poudyal N, Liu JP, Tang L. Mag"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
201 12 36 reference_content 43 Tasoglu S, Kavaz D, Gurkan UA et al. Paramagnetic levitational assembly of hydrogels. Adv. Mater. Weinheim 25(8), 1137–43, 1081 (2013). [767.0, 1309.0, 1071.0, 1391.0] reference_item 0.85 ["reference content label: 43 Tasoglu S, Kavaz D, Gurkan UA et al. Paramagnetic levitat"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
202 12 37 reference_content 44 Lu T, Li Y, Chen T. Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering. Int. J. Nanomed. 8, 337–350 (2013). [766.0, 1399.0, 1078.0, 1482.0] reference_item 0.85 ["reference content label: 44 Lu T, Li Y, Chen T. Techniques for fabrication and constr"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
203 12 38 number 564 [72.0, 1529.0, 110.0, 1549.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
204 12 39 footer Expert Rev. Mol. Diagn. 13(6), (2013) [877.0, 1533.0, 1095.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False
205 13 0 header Use of magnetic nanoparticles as diagnostic & therapeutic tools [404.0, 100.0, 1007.0, 124.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
206 13 1 header Review [1032.0, 94.0, 1127.0, 122.0] noise 0.9 ["header label"] noise 0.9 unknown_like short_fragment False False
207 13 2 reference_content 45 Souza GR, Molina JR, Raphael RM et al. Three-dimensional tissue culture based on magnetic cell levitation. Nat. Nanotechnol. 5(4), 291–296 (2010). [117.0, 176.0, 437.0, 258.0] reference_item 0.85 ["reference content label: 45 Souza GR, Molina JR, Raphael RM et al. Three-dimensional "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
208 13 3 reference_content 46 Daquinag AC, Souza GR, Kolonin MG. Adipose tissue engineering in three-dimensional levitation tissue culture system based on magnetic nanoparticles. Tissue Eng. Part C. Methods 19(5), 336–344 (2013 [118.0, 267.0, 443.0, 390.0] reference_item 0.85 ["reference content label: 46 Daquinag AC, Souza GR, Kolonin MG. Adipose tissue enginee"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
209 13 4 reference_content 47 Tseng H, Gage JA, Raphael RM et al. Assembly of a three-dimensional multitype bronchiole coculture model using magnetic levitation. Tissue Eng. Part C Methods doi:10.1089/ten.tec.2012.0157 (2013) ( [117.0, 399.0, 443.0, 524.0] reference_item 0.85 ["reference content label: 47 Tseng H, Gage JA, Raphael RM et al. Assembly of a three-d"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
210 13 5 reference_content 48 Winkleman A, Bracher PJ, Gitlin I, Whitesides GM. Fabrication and manipulation of ionotropic hydrogels crosslinked by paramagnetic ions. Chem. Mater. 19(6), 1362–1368 (2007). [117.0, 531.0, 441.0, 633.0] reference_item 0.85 ["reference content label: 48 Winkleman A, Bracher PJ, Gitlin I, Whitesides GM. Fabrica"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
211 13 6 reference_content 49 Ito A, Hayashida M, Honda H et al. Construction and harvest of multilayered keratinocyte sheets using magnetite nanoparticles and magnetic force. Tissue Eng. 10(5-6), 873–880 (2004). [118.0, 642.0, 431.0, 745.0] reference_item 0.85 ["reference content label: 49 Ito A, Hayashida M, Honda H et al. Construction and harve"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
212 13 7 reference_content 50 Akiyama H, Ito A, Kawabe Y, Kamihira M. Genetically engineered angiogenic cell sheets using magnetic force-based gene delivery and tissue fabrication techniques. Biomaterials 31(6), 1251–1259 (2010 [118.0, 753.0, 444.0, 855.0] reference_item 0.85 ["reference content label: 50 Akiyama H, Ito A, Kawabe Y, Kamihira M. Genetically engin"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
213 13 8 reference_content • Generation of cell sheets through magnetic technology for the enhancement of vascularization. [117.0, 866.0, 443.0, 927.0] reference_item 0.85 ["reference content label: \u2022 Generation of cell sheets through magnetic technology for "] reference_item 0.85 reference_zone unknown_like none True True
214 13 9 reference_content 51 Kito T, Shibata R, Ishii M et al. iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis. Sci. Rep. 3, 1418 (2013). [119.0, 936.0, 428.0, 1019.0] reference_item 0.85 ["reference content label: 51 Kito T, Shibata R, Ishii M et al. iPS cell sheets created"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
215 13 10 reference_content 52 Ito A, Ino K, Hayashida M et al. Novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force. Tissue Eng. 11(9-10), 1553–1561 (2005). [118.0, 1026.0, 418.0, 1149.0] reference_item 0.85 ["reference content label: 52 Ito A, Ino K, Hayashida M et al. Novel methodology for fa"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
216 13 11 reference_content 53 Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel S. Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigat [118.0, 1158.0, 440.0, 1302.0] reference_item 0.85 ["reference content label: 53 Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel S. C"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
217 13 12 reference_content 54 Russo A, Shelyakova T, Casino D et al. A new approach to scaffold fixation by magnetic forces: application to large osteochondral defects. Med. Eng. Phys. 34(9), 1287–1293 (2012). [118.0, 1312.0, 414.0, 1415.0] reference_item 0.85 ["reference content label: 54 Russo A, Shelyakova T, Casino D et al. A new approach to "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
218 13 13 reference_content 55 Sapir Y, Cohen S, Friedman G, Polyak B. The promotion of in vitro vessel-like organization of endothelial cells in [118.0, 1423.0, 429.0, 1485.0] reference_item 0.85 ["reference content label: 55 Sapir Y, Cohen S, Friedman G, Polyak B. The promotion of "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
219 13 14 reference_content magnetically responsive alginate scaffolds. Biomaterials 33(16), 4100–4109 (2012). [496.0, 177.0, 782.0, 217.0] reference_item 0.85 ["reference content label: magnetically responsive alginate scaffolds. Biomaterials 33("] reference_item 0.85 reference_zone unknown_like none True True
220 13 15 reference_content 56 Wu C, Fan W, Zhu Y et al. Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure. Acta Biomater. 7(10), 3563–3572 (2011). [467.0, 225.0, 791.0, 307.0] reference_item 0.85 ["reference content label: 56 Wu C, Fan W, Zhu Y et al. Multifunctional magnetic mesopo"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
221 13 16 reference_content 57 Tourdias T, Roggerone S, Filippi M et al. Assessment of disease activity in multiple sclerosis phenotypes with combined gadolinium- and superparamagnetic iron oxide-enhanced MR imaging. Radiology 2 [464.0, 315.0, 778.0, 438.0] reference_item 0.85 ["reference content label: 57 Tourdias T, Roggerone S, Filippi M et al. Assessment of d"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
222 13 17 reference_content 58 Yilmaz A, Dengler MA, van der Kuip H et al. Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magne [464.0, 447.0, 791.0, 592.0] reference_item 0.85 ["reference content label: 58 Yilmaz A, Dengler MA, van der Kuip H et al. Imaging of my"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
223 13 18 reference_content 59 Laurencin M, Cam N, Georgelin T et al. Human erythrocytes covered with magnetic core-shell nanoparticles for multimodal imaging. Adv. Healthc. Mater. doi:10.1002/adhm.201200384 (2013) (Epub ahead o [466.0, 600.0, 794.0, 724.0] reference_item 0.85 ["reference content label: 59 Laurencin M, Cam N, Georgelin T et al. Human erythrocytes"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
224 13 19 reference_content 60 Ling Y, Pong T, Vassiliou CC, Huang PL, Cima MJ. Implantable magnetic relaxation sensors measure cumulative exposure to cardiac biomarkers. Nat. Biotechnol. 29(3), 273–277 (2011). [465.0, 732.0, 789.0, 834.0] reference_item 0.85 ["reference content label: 60 Ling Y, Pong T, Vassiliou CC, Huang PL, Cima MJ. Implanta"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
225 13 20 reference_content • Development of implantable magnetic sensors as a tool for monitoring biomarkers in high-risk cardiac patients. [465.0, 844.0, 778.0, 908.0] reference_item 0.85 ["reference content label: \u2022 Development of implantable magnetic sensors as a tool for "] reference_item 0.85 reference_zone unknown_like none True True
226 13 21 reference_content 61 Andreas K, Georgieva R, Ladwig M et al. Highly efficient magnetic stem cell labeling with citrate-coated superparamagnetic iron oxide nanoparticles for MRI tracking. Biomaterials 33(18), 4515–4525 [466.0, 916.0, 793.0, 1017.0] reference_item 0.85 ["reference content label: 61 Andreas K, Georgieva R, Ladwig M et al. Highly efficient "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
227 13 22 reference_content 62 Cromer Berman SM, Walczak P, Bulte JW. Tracking stem cells using magnetic nanoparticles. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 3(4), 343–355 (2011). [465.0, 1026.0, 789.0, 1128.0] reference_item 0.85 ["reference content label: 62 Cromer Berman SM, Walczak P, Bulte JW. Tracking stem cell"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
228 13 23 reference_content 63 Frank JA, Miller BR, Arbab AS et al. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 228(2), 480–487 (2003). [466.0, 1138.0, 789.0, 1241.0] reference_item 0.85 ["reference content label: 63 Frank JA, Miller BR, Arbab AS et al. Clinically applicabl"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
229 13 24 reference_content 64 Bulte JW, Douglas T, Witwer B et al. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat. Biotechnol. 19(12), 1141–1147 (2001). [465.0, 1248.0, 780.0, 1351.0] reference_item 0.85 ["reference content label: 64 Bulte JW, Douglas T, Witwer B et al. Magnetodendrimers al"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
230 13 25 reference_content 65 Wu YL, Ye Q, Foley LM et al. In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc. Natl Acad. Sci. USA 103(6), 1852–1857 (2006). [464.0, 1361.0, 787.0, 1463.0] reference_item 0.85 ["reference content label: 65 Wu YL, Ye Q, Foley LM et al. In situ labeling of immune c"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
231 13 26 reference_content 66 Libani IV, Lucignani G, Gianelli U et al. Labeling protocols for in vivo tracking of human skeletal muscle cells (HSkMCs) by magnetic resonance and bioluminescence imaging. Mol. Imaging Biol. 14(1) [812.0, 176.0, 1134.0, 300.0] reference_item 0.85 ["reference content label: 66 Libani IV, Lucignani G, Gianelli U et al. Labeling protoc"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
232 13 27 reference_content 67 Xu C, Miranda-Nieves D, Ankrum JA et al. Tracking mesenchymal stem cells with iron oxide nanoparticle loaded poly(lactide-co-glycolide) microparticles. Nano Lett. 12(8), 4131–4139 (2012). [812.0, 309.0, 1126.0, 412.0] reference_item 0.85 ["reference content label: 67 Xu C, Miranda-Nieves D, Ankrum JA et al. Tracking mesench"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
233 13 28 reference_content 68 Liu H, Li Y, Wang XY et al. Synthesis, preliminary structure-activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflamm [812.0, 420.0, 1140.0, 564.0] reference_item 0.85 ["reference content label: 68 Liu H, Li Y, Wang XY et al. Synthesis, preliminary struct"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
234 13 29 reference_content 69 Huang H, Delikanli S, Zeng H, Ferkey DM, Pralle A. Remote control of ion channels and neurons through magnetic-field heating of nanoparticles. Nat. Nanotechnol. 5(8), 602–606 (2010). [813.0, 573.0, 1128.0, 676.0] reference_item 0.85 ["reference content label: 69 Huang H, Delikanli S, Zeng H, Ferkey DM, Pralle A. Remote"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
235 13 30 reference_content 70 Durmus NG, Webster TJ. Eradicating antibiotic-resistant biofilms with silver-conjugated superparamagnetic iron oxide nanoparticles. Adv. Healthc. Mater. 2(1), 165–171 (2013). [813.0, 684.0, 1143.0, 786.0] reference_item 0.85 ["reference content label: 70 Durmus NG, Webster TJ. Eradicating antibiotic-resistant b"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
236 13 31 reference_content 71 Assiotis A, Sachinis NP, Chalidis BE. Pulsed electromagnetic fields for the treatment of tibial delayed unions and nonunions. A prospective clinical study and review of the literature. J. Orthop. S [813.0, 794.0, 1143.0, 919.0] reference_item 0.85 ["reference content label: 71 Assiotis A, Sachinis NP, Chalidis BE. Pulsed electromagne"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
237 13 32 reference_content 72 Abdelrahim A, Hassanein HR, Dahaba M. Effect of pulsed electromagnetic field on healing of mandibular fracture: a preliminary clinical study. J. Oral Maxillofac. Surg. 69(6), 1708–1717 (2011). [813.0, 927.0, 1140.0, 1030.0] reference_item 0.85 ["reference content label: 72 Abdelrahim A, Hassanein HR, Dahaba M. Effect of pulsed el"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
238 13 33 reference_content 73 Marcheggiani Muccioli GM, Grassi A, Setti S et al. Conservative treatment of spontaneous osteonecrosis of the knee in the early stage: pulsed electromagnetic fields therapy. Eur. J. Radiol. 82(3), [813.0, 1038.0, 1122.0, 1161.0] reference_item 0.85 ["reference content label: 73 Marcheggiani Muccioli GM, Grassi A, Setti S et al. Conser"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
239 13 34 reference_content 74 Markov MS. Expanding use of pulsed electromagnetic field therapies. Electro-magn. Biol. Med. 26(3), 257–274 (2007). [813.0, 1170.0, 1125.0, 1232.0] reference_item 0.85 ["reference content label: 74 Markov MS. Expanding use of pulsed electromagnetic field "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
240 13 35 reference_content 75 Nelson F, Zvirbulis R, Pilla AA. Non-invasive electromagnetic field therapy produces rapid and substantial pain reduction in early knee osteoarthritis: a randomized double-blind pilot study. Osteoa [812.0, 1239.0, 1116.0, 1382.0] reference_item 0.85 ["reference content label: 75 Nelson F, Zvirbulis R, Pilla AA. Non-invasive electromagn"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
241 13 36 reference_content 76 Brook J, Dauphinee DM, Korpinen J, Rawe IM. Pulsed radiofrequency electromagnetic field therapy: a potential novel treatment of plantar fasciitis. J. Foot Ankle Surg. 51(3), 312–316 (2012). [812.0, 1392.0, 1133.0, 1496.0] reference_item 0.85 ["reference content label: 76 Brook J, Dauphinee DM, Korpinen J, Rawe IM. Pulsed radiof"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
242 13 37 footer www.expert-reviews.com [115.0, 1535.0, 327.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False
243 13 38 number 565 [1103.0, 1530.0, 1141.0, 1549.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
244 14 0 header Review [88.0, 95.0, 183.0, 122.0] noise 0.9 ["header label"] noise 0.9 unknown_like short_fragment False False
245 14 1 header Santo, Rodrigues & Gomes [207.0, 99.0, 458.0, 121.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
246 14 2 reference_content 77 De Mattei M, Caruso A, Pezzetti F et al. Effects of pulsed electromagnetic fields on human articular chondrocyte proliferation. Connect. Tissue Res. 42(4), 269–279 (2001). [71.0, 174.0, 396.0, 276.0] reference_item 0.85 ["reference content label: 77 De Mattei M, Caruso A, Pezzetti F et al. Effects of pulse"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
247 14 3 reference_content 78 De Mattei M, Fini M, Setti S et al. Proteoglycan synthesis in bovine articular cartilage explants exposed to different low-frequency low-energy pulsed electromagnetic fields. Osteoarthr. Cartil. 15 [72.0, 285.0, 389.0, 408.0] reference_item 0.85 ["reference content label: 78 De Mattei M, Fini M, Setti S et al. Proteoglycan synthesi"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
248 14 4 reference_content 79 Chang CH, Loo ST, Liu HL, Fang HW, Lin HY. Can low frequency electromagnetic field help cartilage tissue engineering? J. Biomed. Mater. Res. A 92(3), 843–851 (2010). [72.0, 417.0, 398.0, 519.0] reference_item 0.85 ["reference content label: 79 Chang CH, Loo ST, Liu HL, Fang HW, Lin HY. Can low freque"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
249 14 5 reference_content 80 De Mattei M, Pasello M, Pellati A et al. Effects of electromagnetic fields on proteoglycan metabolism of bovine articular cartilage explants. Connect. Tissue Res. 44(3-4), 154–159 (2003). [73.0, 528.0, 396.0, 631.0] reference_item 0.85 ["reference content label: 80 De Mattei M, Pasello M, Pellati A et al. Effects of elect"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
250 14 6 reference_content 81 Fioravanti A, Nerucci F, Collodel G, Markoll R, Marcolongo R. Biochemical and morphological study of human articular chondrocytes cultivated in the presence of pulsed signal therapy. Ann. Rheum. Di [73.0, 639.0, 377.0, 763.0] reference_item 0.85 ["reference content label: 81 Fioravanti A, Nerucci F, Collodel G, Markoll R, Marcolong"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
251 14 7 reference_content 82 Bobacz K, Graninger WB, Amoyo L, Smolen JS. Effect of pulsed electromagnetic fields on proteoglycan biosynthesis of articular cartilage is age dependent. Ann. Rheum. Dis. 65(7), 949–951 (2006). [72.0, 773.0, 399.0, 874.0] reference_item 0.85 ["reference content label: 82 Bobacz K, Graninger WB, Amoyo L, Smolen JS. Effect of pul"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
252 14 8 reference_content 83 Ongaro A, Pellati A, Masieri FF et al. Chondroprotective effects of pulsed [73.0, 883.0, 358.0, 923.0] reference_item 0.85 ["reference content label: 83 Ongaro A, Pellati A, Masieri FF et al. Chondroprotective "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
253 14 9 reference_content electromagnetic fields on human cartilage explants. Bioelectromagnetics 32(7), 543–551 (2011). [448.0, 177.0, 737.0, 238.0] reference_item 0.85 ["reference content label: electromagnetic fields on human cartilage explants. Bioelect"] reference_item 0.85 reference_zone unknown_like none True True
254 14 10 reference_content 84 Ongaro A, Varani K, Masieri FF et al. Electromagnetic fields (EMFs) and adenosine receptors modulate prostaglandin E(2) and cytokine release in human osteoarthritic synovial fibroblasts. J. Cell. P [420.0, 246.0, 725.0, 390.0] reference_item 0.85 ["reference content label: 84 Ongaro A, Varani K, Masieri FF et al. Electromagnetic fie"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
255 14 11 reference_content 85 Fini M, Pagani S, Giavaresi G et al. Functional tissue engineering in articular cartilage repair: is there a role for electromagnetic biophysical stimulation? Tissue Eng. Part B Rev. doi:10.1089/te [420.0, 399.0, 734.0, 544.0] reference_item 0.85 ["reference content label: 85 Fini M, Pagani S, Giavaresi G et al. Functional tissue en"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
256 14 12 reference_content 86 de Girolamo L, Stanco D, Galliera E et al. Low frequency pulsed electromagnetic field affects proliferation, tissue-specific gene expression, and cytokines release of human tendon cells. Cell Bioch [421.0, 551.0, 746.0, 677.0] reference_item 0.85 ["reference content label: 86 de Girolamo L, Stanco D, Galliera E et al. Low frequency "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
257 14 13 reference_content 87 Hannouche D, Petite H, Sedel L. Current trends in the enhancement of fracture healing. J. Bone Joint Surg. Br. 83(2), 157–164 (2001). [421.0, 684.0, 737.0, 765.0] reference_item 0.85 ["reference content label: 87 Hannouche D, Petite H, Sedel L. Current trends in the enh"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
258 14 14 reference_content 88 Kuzyk PR, Schemitsch EH. The science of electrical stimulation therapy for fracture healing. Indian J. Orthop. 43(2), 127–131 (2009). [421.0, 774.0, 742.0, 855.0] reference_item 0.85 ["reference content label: 88 Kuzyk PR, Schemitsch EH. The science of electrical stimul"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
259 14 15 reference_content 89 Callaghan MJ, Chang EI, Seiser N et al. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by [421.0, 863.0, 726.0, 926.0] reference_item 0.85 ["reference content label: 89 Callaghan MJ, Chang EI, Seiser N et al. Pulsed electromag"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
260 14 16 reference_content increasing endogenous FGF-2 release. Plast. Reconstr. Surg. 121(1), 130–141 (2008). [797.0, 178.0, 1055.0, 238.0] reference_item 0.85 ["reference content label: increasing endogenous FGF-2 release. Plast. Reconstr. Surg. "] reference_item 0.85 reference_zone unknown_like none True True
261 14 17 reference_content 90 Smith TL, Wong-Gibbons D, Maultsby J. Microcirculatory effects of pulsed electromagnetic fields. J. Orthop. Res. 22(1), 80–84 (2004). [766.0, 246.0, 1083.0, 327.0] reference_item 0.85 ["reference content label: 90 Smith TL, Wong-Gibbons D, Maultsby J. Microcirculatory ef"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
262 14 18 reference_content 91 Strauch B, Patel MK, Rosen DJ, Mahadevia S, Brindzei N, Pilla AA. Pulsed magnetic field therapy increases tensile strength in a rat Achilles' tendon repair model. J. Hand Surg. Am. 31(7), 1131–1135 [766.0, 336.0, 1096.0, 459.0] reference_item 0.85 ["reference content label: 91 Strauch B, Patel MK, Rosen DJ, Mahadevia S, Brindzei N, P"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
263 14 19 reference_content 92 Nakabayashi A, Kamei N, Sunagawa T et al. In vivo bioluminescence imaging of magnetically targeted bone marrow-derived mesenchymal stem cells in skeletal muscle injury model. J. Orthop. Res. 31(5), [767.0, 467.0, 1097.0, 591.0] reference_item 0.85 ["reference content label: 92 Nakabayashi A, Kamei N, Sunagawa T et al. In vivo biolumi"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
264 14 20 reference_content 93 Tefft BJ, Gooden JY, Uthamaraj S et al. Magnetizable duplex steel stents enable endothelial cell capture. IEEE Trans. Magn. 49(1), 463–466 (2013). [767.0, 599.0, 1095.0, 682.0] reference_item 0.85 ["reference content label: 93 Tefft BJ, Gooden JY, Uthamaraj S et al. Magnetizable dupl"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
265 14 21 reference_content 94 Arendash GW. Transcranial electromagnetic treatment against Alzheimer's disease: why it has the potential to trump Alzheimer's disease drug development. J. Alzheimer's Dis. 32(2), 243–266 (2012). [766.0, 690.0, 1095.0, 814.0] reference_item 0.85 ["reference content label: 94 Arendash GW. Transcranial electromagnetic treatment again"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
266 14 22 reference_content 95 Kova ík P, Kremlá ková Z, Št pánek F. Investigation of radiofrequency induced release kinetics from magnetic hollow silica microspheres. Microporous Mesoporous Mater. 159, 119 (2012). [765.0, 821.0, 1094.0, 924.0] reference_item 0.85 ["reference content label: 95 Kova \u00edk P, Kreml\u00e1 kov\u00e1 Z, \u0160t p\u00e1nek F. Investigation of ra"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
267 14 23 number 566 [71.0, 1529.0, 110.0, 1550.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
268 14 24 footer Expert Rev. Mol. Diagn. 13(6), (2013) [877.0, 1533.0, 1095.0, 1553.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False

70
audit/27MSS3VH/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,70 @@
{
"figures": {
"matched_count": 4,
"ambiguous_count": 0,
"unresolved_cluster_count": 0,
"unmatched_asset_count": 0,
"matched": [
{
"figure_number": 1,
"legend_block_id": 4,
"asset_block_ids": [
3
],
"page": 3,
"match_type": null
},
{
"figure_number": 2,
"legend_block_id": 7,
"asset_block_ids": [
6
],
"page": 6,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 3,
"asset_block_ids": [
2
],
"page": 8,
"match_type": null
},
{
"figure_number": 4,
"legend_block_id": 2,
"asset_block_ids": [
1
],
"page": 10,
"match_type": null
}
],
"ambiguous": [],
"unresolved": []
},
"tables": {
"matched_count": 2,
"ambiguous_count": 0,
"unmatched_asset_count": 0,
"matched": [
{
"table_number": 1,
"caption_block_id": 2,
"asset_block_ids": [],
"page": 4,
"match_status": "matched"
},
{
"table_number": 1,
"caption_block_id": 2,
"asset_block_ids": [],
"page": 5,
"match_status": "matched"
}
],
"ambiguous": []
}
}

2527
audit/27MSS3VH/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

304
audit/27MSS3VH/page_risk_summary.json Normal file
View file

@ -0,0 +1,304 @@
{
"pages": [
{
"page": 1,
"risk_score": 5,
"risk_reasons": [
"frontmatter_page"
],
"recommended_audit_targets": [
"frontmatter"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 8,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 3,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 4,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 2,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 5,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 2,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 7,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 8,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 8,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 8,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 9,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 12,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 10,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 11,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 12,
"reference_item": 16,
"tail_like": 2,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 12,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 36,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 13,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 35,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 14,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 21,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
3,
4,
5,
6,
8,
10,
11
]
}

851
audit/27MSS3VH/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,851 @@
{
"candidates": [
{
"block_id": "p11:17",
"page": 11,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:18",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:19",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:20",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:21",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:22",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:23",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:24",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:25",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:26",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:27",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:28",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:29",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:30",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:31",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:32",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:33",
"page": 11,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:34",
"page": 11,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p11:35",
"page": 11,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:0",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:1",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:2",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:3",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:4",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:5",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:6",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:7",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:8",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:9",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:10",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:11",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:12",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:13",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:14",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:15",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:16",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:17",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:18",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:19",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:20",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:21",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:22",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:23",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:24",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:25",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:26",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:27",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:28",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:29",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:30",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:31",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:32",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:33",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:34",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:35",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:36",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:37",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:38",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:39",
"page": 12,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:0",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:1",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:2",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:3",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:4",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:5",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:6",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:7",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:8",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:9",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:10",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:11",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:12",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:13",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:14",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:15",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:16",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:17",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:18",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:19",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:20",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:21",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:22",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:23",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:24",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:25",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:26",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:27",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:28",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:29",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:30",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:31",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:32",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:33",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:34",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:35",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:36",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:37",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:38",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:0",
"page": 14,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:1",
"page": 14,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:2",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:3",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:4",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:5",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:6",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:7",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:8",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:9",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:10",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:11",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:12",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:13",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:14",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:15",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:16",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:17",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:18",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:19",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:20",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:21",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:22",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

1094
audit/27MSS3VH/reference_span_audit.json Normal file
View file

File diff suppressed because it is too large Load diff

808
audit/28ALPCY7/audit_report.json Normal file
View file

@ -0,0 +1,808 @@
{
"paper_key": "28ALPCY7",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:4563ab61cf185112fb25b8cf3256ac2407ac8874cb434dec907175deb631eb0a",
"meta_json_hash": "sha256:a8706490e517b333a64852d88c134a84accf4c0142e3088827956c08439261dd",
"blocks_raw_hash": "sha256:097f7433280340b17312b306c433b7edf914a258999335c946a5db4818764508",
"structured_blocks_hash": "sha256:6471f95bfa6cf13e122e75ea95bdb1b25ec2f3c90198a39625012a470014bbce",
"document_structure_hash": "sha256:67aacbe36a3c177749c6c652fc4467e3fca542baacc47d40fea46ecce9157880",
"figure_inventory_hash": "sha256:21791eecfe3b34c9dc94178f48217dfe81d5fb7e665e31fab5c7bbc6fbff4cd5",
"table_inventory_hash": "sha256:e1ca995b94bef164d970db84622eb9476bbfea0741e723a0cc51a422e79bdc40",
"reader_figures_hash": "sha256:0302944c62e9ff76c7633f87ba79d8f5c1122f53c6b0c89ad8afc3669a56fcf3",
"resolved_metadata_hash": "sha256:40bee7638f0c53e54ecd21ae078ba73c88a6fa0956930173d34e9eeb8ca5ede2",
"fulltext_hash": "sha256:e00fee84e8e7cc151626fa1cdc0c9df4acb8f5dee72a7aa81418e6e8ed147f62",
"block_trace_hash": "sha256:7161e2cf631242c6ddd356c5a4f1201398b0becc05c4b02688deab451415a6f6",
"annotated_pages": {
"page_001.png": "sha256:d2edd69923ad24d26711cab34bdd90b5910a82a5c595d46ad82f02478244d0a5",
"page_002.png": "sha256:3331a871f529b4a2a1b54b747db09f5de902172f5801ee8f12cd515fbbc0008d",
"page_003.png": "sha256:4685deb5c1eaafcb135001dda740eea828d2a9a510681717dc5d2c8577f444f9",
"page_004.png": "sha256:1acfadec42c2f08d1f87871d4c783135ee5d67417366f61335c085ccd99abf18",
"page_005.png": "sha256:bbd13836732b70a56fc5f854a41726231390c9c20172daf9bd3350fb24dcc329",
"page_006.png": "sha256:c12d8272dfb462099c3f718de4ba083edc8236eaab755d0c9ff58f9837dd66a2",
"page_007.png": "sha256:4917f4257b27095dbda9dd2311442fdfb347fe418e1d7d9560b387035ceba883",
"page_008.png": "sha256:9221e366166ade36608c56b66a3724bc945d7469065ec2f474fe7775c27e1e78",
"page_009.png": "sha256:6e18995c4e1a7c59c46294bcfe598f3d609d3e7bf04722983785aa56f83d557a",
"page_010.png": "sha256:cc8a84a890ca6159111ffd37216de95ac35e47f7a8fb3baf602a6a0480e897a1",
"page_011.png": "sha256:ff67a69c53f5e99d3b096f63760bae2c83081da36668b4c8e1b71ae7a195719c",
"page_012.png": "sha256:0548c0933e5c1c1240df33cd741b1bf703bf7d5b501fe10050d97bb3803b71f7",
"page_013.png": "sha256:b556a8d484c8937f996101a102e4be6706076f0929bbb4c1f1d9265ce0a1eeb6",
"page_014.png": "sha256:d114049a184309865c9c8a20a3042b9fca20e4cc467019dc6d48eae99394833b",
"page_015.png": "sha256:2b11a349a38e870ad365059865acbfaf09e9f6d0f130e93f32ef0b8f42ad6a39",
"page_016.png": "sha256:9b186cedc2582e240e924e1ae4e051f19a3f329b74d28f0db74159d7fac8b6f2",
"page_017.png": "sha256:636ee57f5322fc8c40c31675bb8488dea7abb9b8ee9b86cc5f5ade4ec2123e84",
"page_018.png": "sha256:d73f19c814ed76ff2b976d33e43f41a8b0b9192ad35e6dcac7c887af491c0554",
"page_019.png": "sha256:f2d6098255c7be4bdcc14e6a89fadc696c55368f7a12798ddd7311e3bde14ed2",
"page_020.png": "sha256:bc7e595a178154c83f331d36da51ea28350dbbbfca94d79827cfd5b5f2979f40",
"page_021.png": "sha256:5b09913c11638ea354c0b4cc79a4db44b4481b9e690fa2ba43b59344321b3345",
"page_022.png": "sha256:5d4746435d4d72317e0e874e513fc48c5b6334bc39f2318bd197631728e8362c",
"page_023.png": "sha256:8865321fb368fc6de121e5edb1e60088461fa92178e09a4d46ffe6d18a9e1641",
"page_024.png": "sha256:39d8504fe9a25b6cf5f8382d8596cd4da6b6c92ec1171563c1ee38903323760d",
"page_025.png": "sha256:ec37c98d2f27251bb01b89f799a878932c9fe6108341fb9a028d0961efb2f645",
"page_026.png": "sha256:c3c1b74adc7fdab1b7d6d95bcb6c620e234675b861b8e20e0217b6c49264b5e9",
"page_027.png": "sha256:b26b54e5e76dd8e93acc7bf7f75267108de2c2759db565faba0cfddf632a094f",
"page_028.png": "sha256:633d3a124c7396ba5df1f3114082c42c0f2b479a9c6421fa4731883f8149c88e",
"page_029.png": "sha256:9e6326690ed49c02b0c4aa7078e47d1e1443d5fda00c01440bc131f713507fe7",
"page_030.png": "sha256:c95daa438bc2c20045736746912e035a9edd6987bf63dc226fb10a381e550b71",
"page_031.png": "sha256:01f71a1b3850eacd3d4b9bccf0ee31280f5e098904a1b29d707976b328545c6a",
"page_032.png": "sha256:d2592b9d38435b200dc7f5b32723f9f3f4751bbb62a64a0732e860d757268cb2",
"page_033.png": "sha256:7151e790d8ab3fe1123928c4653846e2d9cf655319c2ddd4f4b1de77a58bec64",
"page_034.png": "sha256:0083baa54205ef32fe646cb9f64c9230fc85113905c35eeff41b56b0b44dcfdd",
"page_035.png": "sha256:0cdd750fe28ef08fa089d2f773c21a6b5ab303c447392b947ed2e0169c4e252b",
"page_036.png": "sha256:5e184127b35843f1d55910a0f2d6538f34d60f7e611562978e35c52169c5eceb",
"page_037.png": "sha256:f2e6e8e5505e1edbdca6f3882c4f8066e35777460c4ca3cfb88bdef6d2664f18"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png",
"page_008.png",
"page_009.png",
"page_010.png",
"page_011.png",
"page_012.png",
"page_013.png",
"page_014.png",
"page_015.png",
"page_016.png",
"page_017.png",
"page_018.png",
"page_019.png",
"page_020.png",
"page_021.png",
"page_022.png",
"page_023.png",
"page_024.png",
"page_025.png",
"page_026.png",
"page_027.png",
"page_028.png",
"page_029.png",
"page_030.png",
"page_031.png",
"page_032.png",
"page_033.png",
"page_034.png",
"page_035.png",
"page_036.png",
"page_037.png"
]
},
"reviewed_pages": [
1,
2,
9,
12,
13,
15,
16,
17,
19,
22,
23,
25,
26,
27,
28,
29,
30,
31,
32,
33,
34,
35,
36
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p2:0",
"p2:1",
"p2:2",
"p2:3",
"p2:4",
"p2:5",
"p2:6",
"p2:7",
"p2:8",
"p2:9",
"p2:10",
"p9:0",
"p9:1",
"p9:2",
"p9:3",
"p9:4",
"p9:5",
"p9:6",
"p9:7",
"p9:8",
"p9:9",
"p12:0",
"p12:1",
"p12:2",
"p12:3",
"p12:4",
"p12:5",
"p12:6",
"p12:7",
"p12:8",
"p12:9",
"p12:10",
"p12:11",
"p13:0",
"p13:1",
"p13:2",
"p13:3",
"p13:4",
"p13:5",
"p13:6",
"p13:7",
"p13:8",
"p13:9",
"p13:10",
"p13:11",
"p15:0",
"p15:1",
"p15:2",
"p15:3",
"p15:4",
"p15:5",
"p15:6",
"p15:7",
"p16:0",
"p16:1",
"p16:2",
"p16:3",
"p16:4",
"p16:5",
"p16:6",
"p17:0",
"p17:1",
"p17:2",
"p17:3",
"p17:4",
"p17:5",
"p17:6",
"p17:7",
"p17:8",
"p17:9",
"p17:10",
"p17:11",
"p17:12",
"p17:13",
"p19:0",
"p19:1",
"p19:2",
"p19:3",
"p19:4",
"p19:5",
"p19:6",
"p19:7",
"p19:8",
"p19:9",
"p19:10",
"p22:0",
"p22:1",
"p22:2",
"p22:3",
"p22:4",
"p22:5",
"p22:6",
"p23:0",
"p23:1",
"p23:2",
"p23:3",
"p23:4",
"p23:5",
"p23:6",
"p23:7",
"p25:0",
"p25:1",
"p25:2",
"p25:3",
"p25:4",
"p25:5",
"p25:6",
"p25:7",
"p26:0",
"p26:1",
"p26:2",
"p26:3",
"p26:4",
"p26:5",
"p27:0",
"p27:1",
"p27:2",
"p27:3",
"p27:4",
"p27:5",
"p27:6",
"p28:0",
"p28:1",
"p28:2",
"p28:3",
"p28:4",
"p28:5",
"p28:6",
"p28:7",
"p28:8",
"p29:0",
"p29:1",
"p29:2",
"p29:3",
"p29:4",
"p29:5",
"p29:6",
"p29:7",
"p29:8",
"p29:9",
"p29:10",
"p29:11",
"p29:12",
"p30:0",
"p30:1",
"p30:2",
"p30:3",
"p30:4",
"p30:5",
"p30:6",
"p30:7",
"p30:8",
"p30:9",
"p31:0",
"p31:1",
"p31:2",
"p31:3",
"p31:4",
"p31:5",
"p31:6",
"p31:7",
"p31:8",
"p31:9",
"p31:10",
"p32:0",
"p32:1",
"p32:2",
"p32:3",
"p32:4",
"p32:5",
"p32:6",
"p32:7",
"p32:8",
"p32:9",
"p32:10",
"p33:0",
"p33:1",
"p33:2",
"p33:3",
"p33:4",
"p33:5",
"p33:6",
"p33:7",
"p33:8",
"p33:9",
"p33:10",
"p33:11",
"p33:12",
"p34:0",
"p34:1",
"p34:2",
"p34:3",
"p34:4",
"p34:5",
"p34:6",
"p34:7",
"p34:8",
"p34:9",
"p34:10",
"p34:11",
"p35:0",
"p35:1",
"p35:2",
"p35:3",
"p35:4",
"p35:5",
"p35:6",
"p35:7",
"p35:8",
"p36:0",
"p36:1",
"p36:2",
"p36:3",
"p36:4",
"p36:5",
"p36:6",
"p36:7",
"p36:8",
"p36:9",
"p36:10",
"p36:11",
"p36:12",
"p36:13",
"p36:14",
"p36:15",
"p36:16",
"p36:17",
"p36:18"
],
"findings": [
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p28:6"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_028.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p28:7"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_028.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p28:8"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_028.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:1"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:2"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:3"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:4"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:5"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:6"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:7"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:8"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:9"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:10"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:11"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p29:12"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p30:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_030.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p30:1"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_030.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p30:2"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_030.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p30:3"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_030.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "frontmatter_error",
"severity": "major",
"block_ids": [],
"truth": "page 1 should have clearer frontmatter role resolution",
"pipeline_behavior": "frontmatter page retains elevated unknown_structural density",
"root_cause_hypothesis": "frontmatter anchor or noise routing weakness",
"evidence": {
"annotated_page": "annotated_pages/page_001.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_028.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_029.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_030.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_031.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_032.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_033.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_034.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_035.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "object_ownership_error",
"severity": "major",
"block_ids": [],
"truth": "figure/table ownership should map captions and assets coherently",
"pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set",
"root_cause_hypothesis": "caption-to-asset grouping ambiguity",
"evidence": {
"annotated_page": null,
"artifact": "figure_table_ownership_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:9",
"p1:10",
"p1:11",
"p2:0",
"p2:1",
"p2:3",
"p2:4",
"p2:5",
"p2:6",
"p2:7",
"p2:10",
"p3:0",
"p3:2",
"p3:5",
"p3:6",
"p3:7"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

46
audit/28ALPCY7/audit_report.md Normal file
View file

@ -0,0 +1,46 @@
# OCR Truth Audit Report - 28ALPCY7
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 2, 9, 12, 13, 15, 16, 17, 19, 22, 23, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36]
- Reviewed blocks: 240
## Findings
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

2176
audit/28ALPCY7/audit_scope.json Normal file
View file

File diff suppressed because it is too large Load diff

7004
audit/28ALPCY7/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

2491
audit/28ALPCY7/block_trace.csv Normal file
View file

File diff suppressed because it is too large Load diff

135
audit/28ALPCY7/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,135 @@
{
"figures": {
"matched_count": 9,
"ambiguous_count": 0,
"unresolved_cluster_count": 2,
"unmatched_asset_count": 4,
"matched": [
{
"figure_number": 1,
"legend_block_id": 8,
"asset_block_ids": [
4,
5,
7,
6
],
"page": 12,
"match_type": null
},
{
"figure_number": 2,
"legend_block_id": 10,
"asset_block_ids": [
4,
5,
6,
7,
8,
9
],
"page": 13,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 4,
"asset_block_ids": [
3
],
"page": 15,
"match_type": null
},
{
"figure_number": 4,
"legend_block_id": 4,
"asset_block_ids": [
3
],
"page": 16,
"match_type": null
},
{
"figure_number": 5,
"legend_block_id": 11,
"asset_block_ids": [
10,
9
],
"page": 17,
"match_type": null
},
{
"figure_number": 7,
"legend_block_id": 4,
"asset_block_ids": [
3
],
"page": 22,
"match_type": null
},
{
"figure_number": 8,
"legend_block_id": 5,
"asset_block_ids": [
4
],
"page": 23,
"match_type": null
},
{
"figure_number": 9,
"legend_block_id": 5,
"asset_block_ids": [
4
],
"page": 27,
"match_type": null
},
{
"figure_number": 6,
"legend_block_id": 3,
"asset_block_ids": [
9
],
"page": 19,
"match_type": null
}
],
"ambiguous": [],
"unresolved": [
{
"figure_number": null,
"asset_block_ids": [],
"page": 17
},
{
"figure_number": null,
"asset_block_ids": [],
"page": 19
}
]
},
"tables": {
"matched_count": 2,
"ambiguous_count": 0,
"unmatched_asset_count": 8,
"matched": [
{
"table_number": 1,
"caption_block_id": 5,
"asset_block_ids": [],
"page": 9,
"match_status": "matched"
},
{
"table_number": null,
"caption_block_id": 3,
"asset_block_ids": [],
"page": 36,
"match_status": "matched"
}
],
"ambiguous": []
}
}

2887
audit/28ALPCY7/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

830
audit/28ALPCY7/page_risk_summary.json Normal file
View file

@ -0,0 +1,830 @@
{
"pages": [
{
"page": 1,
"risk_score": 7,
"risk_reasons": [
"frontmatter_page",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"frontmatter"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 1,
"unknown_structural": 3,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 4,
"risk_reasons": [
"hold_threshold",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"reading_order"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 2,
"unknown_structural": 2,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 3,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 4,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 5,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 7,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 8,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 9,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 2,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 10,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 11,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 12,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 4,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 13,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 6,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 14,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 15,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 16,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 17,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 6,
"table_like": 0,
"captions": 3,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 18,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 5,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 19,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 3,
"table_like": 0,
"captions": 3,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 20,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 21,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 22,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 23,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 24,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 25,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 7,
"media_assets": 4,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 26,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 5,
"media_assets": 2,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 27,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 6,
"media_assets": 2,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 28,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 2,
"reference_item": 1,
"tail_like": 1,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 29,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 8,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 30,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 5,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 31,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 6,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 32,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 6,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 33,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 8,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 34,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 7,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 35,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 4,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 36,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 5,
"table_like": 2,
"captions": 1,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 37,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 1,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
2,
9,
12,
13,
15,
16,
17,
19,
22,
23,
25,
26,
27,
28,
29,
30,
31,
32,
33,
34,
35,
36
]
}

571
audit/28ALPCY7/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,571 @@
{
"candidates": [
{
"block_id": "p28:6",
"page": 28,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p28:7",
"page": 28,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p28:8",
"page": 28,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:0",
"page": 29,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:1",
"page": 29,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:2",
"page": 29,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:3",
"page": 29,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:4",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:5",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:6",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:7",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:8",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:9",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:10",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:11",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:12",
"page": 29,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:0",
"page": 30,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:1",
"page": 30,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:2",
"page": 30,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:3",
"page": 30,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:4",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:5",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:6",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:7",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:8",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:9",
"page": 30,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:0",
"page": 31,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:1",
"page": 31,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:2",
"page": 31,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:3",
"page": 31,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:4",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:5",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:6",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:7",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:8",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:9",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:10",
"page": 31,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:0",
"page": 32,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:1",
"page": 32,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:2",
"page": 32,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:3",
"page": 32,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:4",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:5",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:6",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:7",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:8",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:9",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:10",
"page": 32,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:0",
"page": 33,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:1",
"page": 33,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:2",
"page": 33,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:3",
"page": 33,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:4",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:5",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:6",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:7",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:8",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:9",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:10",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:11",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:12",
"page": 33,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:0",
"page": 34,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:1",
"page": 34,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:2",
"page": 34,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:3",
"page": 34,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:4",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:5",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:6",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:7",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:8",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:9",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:10",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:11",
"page": 34,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:0",
"page": 35,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:1",
"page": 35,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:2",
"page": 35,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:3",
"page": 35,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:4",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:5",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:6",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:7",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

688
audit/28ALPCY7/reference_span_audit.json Normal file
View file

@ -0,0 +1,688 @@
{
"reference_span": {
"status": "ACCEPT",
"span_id": "refspan_001",
"start": {
"page": 28,
"column": 1,
"y": 1411.0,
"block_id": "p28:6"
},
"end": {
"page": 35,
"column": 1,
"y": 852.0,
"block_id": "p35:7"
},
"heading_block_id": "p28:6",
"ordered_block_ids": [
"p28:6",
"p28:7",
"p29:4",
"p29:5",
"p29:6",
"p29:7",
"p29:8",
"p29:9",
"p29:10",
"p29:11",
"p30:4",
"p30:5",
"p30:6",
"p30:7",
"p30:8",
"p31:4",
"p31:5",
"p31:6",
"p31:7",
"p31:8",
"p31:9",
"p32:4",
"p32:5",
"p32:6",
"p32:7",
"p32:8",
"p32:9",
"p33:4",
"p33:5",
"p33:6",
"p33:7",
"p33:8",
"p33:9",
"p33:10",
"p33:11",
"p34:4",
"p34:5",
"p34:6",
"p34:7",
"p34:8",
"p34:9",
"p34:10",
"p35:4",
"p35:5",
"p35:6",
"p35:7"
],
"inside_block_ids": [
"p28:6",
"p28:7",
"p29:4",
"p29:5",
"p29:6",
"p29:7",
"p29:8",
"p29:9",
"p29:10",
"p29:11",
"p30:4",
"p30:5",
"p30:6",
"p30:7",
"p30:8",
"p31:4",
"p31:5",
"p31:6",
"p31:7",
"p31:8",
"p31:9",
"p32:4",
"p32:5",
"p32:6",
"p32:7",
"p32:8",
"p32:9",
"p33:4",
"p33:5",
"p33:6",
"p33:7",
"p33:8",
"p33:9",
"p33:10",
"p33:11",
"p34:4",
"p34:5",
"p34:6",
"p34:7",
"p34:8",
"p34:9",
"p34:10",
"p35:4",
"p35:5",
"p35:6",
"p35:7"
],
"explicitly_outside_nearby_block_ids": [
"p28:5",
"p35:8"
],
"intrusion_candidates": [
{
"block_id": "p28:6",
"page": 28,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p28:7",
"page": 28,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p28:8",
"page": 28,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:0",
"page": 29,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:1",
"page": 29,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:2",
"page": 29,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:3",
"page": 29,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:4",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:5",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:6",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:7",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:8",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:9",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:10",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:11",
"page": 29,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p29:12",
"page": 29,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:0",
"page": 30,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:1",
"page": 30,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:2",
"page": 30,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:3",
"page": 30,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:4",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:5",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:6",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:7",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:8",
"page": 30,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p30:9",
"page": 30,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:0",
"page": 31,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:1",
"page": 31,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:2",
"page": 31,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:3",
"page": 31,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:4",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:5",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:6",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:7",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:8",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:9",
"page": 31,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p31:10",
"page": 31,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:0",
"page": 32,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:1",
"page": 32,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:2",
"page": 32,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:3",
"page": 32,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:4",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:5",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:6",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:7",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:8",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:9",
"page": 32,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p32:10",
"page": 32,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:0",
"page": 33,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:1",
"page": 33,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:2",
"page": 33,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:3",
"page": 33,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:4",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:5",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:6",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:7",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:8",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:9",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:10",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:11",
"page": 33,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p33:12",
"page": 33,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:0",
"page": 34,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:1",
"page": 34,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:2",
"page": 34,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:3",
"page": 34,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:4",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:5",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:6",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:7",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:8",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:9",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:10",
"page": 34,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p34:11",
"page": 34,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:0",
"page": 35,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:1",
"page": 35,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:2",
"page": 35,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:3",
"page": 35,
"role": "body_paragraph",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:4",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:5",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:6",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p35:7",
"page": 35,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}
}

490
audit/2AGGSMVQ/audit_report.json Normal file
View file

@ -0,0 +1,490 @@
{
"paper_key": "2AGGSMVQ",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:26dda8f027ecc3237fb5beeaceee2e0c2da4a77d5af28266d6669a2b427956eb",
"meta_json_hash": "sha256:172ac349c83851cf8eaf62299e2928ba2fdafe612f402e9f659b962e1a8b701d",
"blocks_raw_hash": "sha256:66cbceb2871717458cdb0433936e1c516b52d8f284a85237d4378d3efcfeec1a",
"structured_blocks_hash": "sha256:c831a4817362c499740c465e559f1c8ef72822daee8f723145073c6f95f1d3dc",
"document_structure_hash": "sha256:31b60457f4dcd3d81b1c7fcffb28a1b78517bf572435344976ca2142662c412e",
"figure_inventory_hash": "sha256:daec3ab64dc1995c2ba4c83e9743a845e43db810c0f200f4dc23c5573f319deb",
"table_inventory_hash": "sha256:86ccb48fbfd41da91e87ea2c1ef938513732868efcb5e30b31c36f96d432bba2",
"reader_figures_hash": "sha256:3da81874d03437fc77f56020dfb83c3d0a6db954aca0d7b74a057f08e31b67f2",
"resolved_metadata_hash": "sha256:eea72e084df39b92d215332c39af7d6b6605446310098ad3f3614e87d8b9f788",
"fulltext_hash": "sha256:1e70490933ec8db52b220372d034a66c78c391f5e12cdcf63dd703329b0ed608",
"block_trace_hash": "sha256:8b7810df12499cb686abd853eea65a354382eb68d27fdfe4fd598a1d4c729fb1",
"annotated_pages": {
"page_001.png": "sha256:4c093cd97a4224d8c695424d14e7d48f26927be0c9275a326ed4f7c35b435a18",
"page_002.png": "sha256:51a6607b700fdd698f38f9c64ab52391cf95fbcfbe1939ead20751fb32d5cc98",
"page_003.png": "sha256:ed187e1909a6e510838bbc900407b0abc88e1aa3473656b388ba739802f587cc",
"page_004.png": "sha256:ba5ca7dfdff2a3a1287dc1f5119d2f92c7440b1cf810e4f4320c4fefcc7f8f69",
"page_005.png": "sha256:d3426d9d1c40606cf1e628ed51cb6394036702f9b62f711f58a2d7e1071d3971",
"page_006.png": "sha256:015b364e0c40548c0d00547ade3fdf3b8d6bcf0665388465dab33cbe38d7016b"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png"
]
},
"reviewed_pages": [
1,
2,
3,
4,
5
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p1:19",
"p1:20",
"p2:0",
"p2:1",
"p2:2",
"p2:3",
"p2:4",
"p2:5",
"p2:6",
"p2:7",
"p2:8",
"p2:9",
"p2:10",
"p2:11",
"p2:12",
"p2:13",
"p2:14",
"p2:15",
"p2:16",
"p2:17",
"p2:18",
"p2:19",
"p2:20",
"p2:21",
"p2:22",
"p3:0",
"p3:1",
"p3:2",
"p3:3",
"p3:4",
"p3:5",
"p3:6",
"p3:7",
"p3:8",
"p3:9",
"p3:10",
"p3:11",
"p3:12",
"p3:13",
"p3:14",
"p3:15",
"p4:0",
"p4:1",
"p4:2",
"p4:3",
"p4:4",
"p4:5",
"p4:6",
"p4:7",
"p4:8",
"p4:9",
"p4:10",
"p4:11",
"p4:12",
"p4:13",
"p4:14",
"p4:15",
"p4:16",
"p5:0",
"p5:1",
"p5:2",
"p5:3",
"p5:4",
"p5:5",
"p5:6",
"p5:7",
"p5:8",
"p5:9",
"p5:10",
"p5:11",
"p5:12",
"p5:13",
"p5:14",
"p5:15",
"p5:16",
"p5:17",
"p5:18",
"p5:19",
"p5:20"
],
"findings": [
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:13"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:14"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:15"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:16"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:17"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:18"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:19"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p5:20"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:1"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:2"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:3"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:4"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:5"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:6"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:7"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:8"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:9"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:10"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p6:11"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_006.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_005.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "object_ownership_error",
"severity": "major",
"block_ids": [],
"truth": "figure/table ownership should map captions and assets coherently",
"pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set",
"root_cause_hypothesis": "caption-to-asset grouping ambiguity",
"evidence": {
"annotated_page": null,
"artifact": "figure_table_ownership_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:0",
"p1:2",
"p1:17",
"p1:20",
"p2:0",
"p2:1",
"p2:3",
"p2:4",
"p2:7",
"p2:22",
"p3:0",
"p3:1",
"p3:8",
"p3:15",
"p4:0",
"p4:1",
"p4:16",
"p5:0",
"p5:1",
"p5:6"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

38
audit/2AGGSMVQ/audit_report.md Normal file
View file

@ -0,0 +1,38 @@
# OCR Truth Audit Report - 2AGGSMVQ
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 2, 3, 4, 5]
- Reviewed blocks: 98
## Findings
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

697
audit/2AGGSMVQ/audit_scope.json Normal file
View file

@ -0,0 +1,697 @@
{
"mode": "high-risk",
"selected_pages": [
1,
2,
3,
4,
5
],
"required_block_ids": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p1:19",
"p1:20",
"p2:3",
"p2:4",
"p2:7",
"p2:17",
"p3:2",
"p3:10",
"p3:13",
"p4:2",
"p4:9",
"p4:14",
"p5:5",
"p5:6",
"p5:13",
"p5:14",
"p5:15",
"p5:16",
"p5:17",
"p5:18",
"p5:19",
"p5:20"
],
"required_blocks": [
{
"block_id": "p1:0",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:1",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:2",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:3",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:4",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:5",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:6",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:7",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:8",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:9",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:10",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:11",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:12",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:13",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:14",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:15",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:16",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:17",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:18",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:19",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p1:20",
"page": 1,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p2:3",
"page": 2,
"required_reason": [
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p2:4",
"page": 2,
"required_reason": [
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p2:7",
"page": 2,
"required_reason": [
"needs_resolution"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p2:17",
"page": 2,
"required_reason": [
"frontmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p3:2",
"page": 3,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p3:10",
"page": 3,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p3:13",
"page": 3,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:2",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:9",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:14",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:5",
"page": 5,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:6",
"page": 5,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:13",
"page": 5,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:14",
"page": 5,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:15",
"page": 5,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:16",
"page": 5,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:17",
"page": 5,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:18",
"page": 5,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:19",
"page": 5,
"required_reason": [
"reference_span"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p5:20",
"page": 5,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
}
],
"selected_page_requirements": [
{
"page": 1,
"must_review_page": true,
"required_block_count": 21
},
{
"page": 2,
"must_review_page": true,
"required_block_count": 4
},
{
"page": 3,
"must_review_page": true,
"required_block_count": 3
},
{
"page": 4,
"must_review_page": true,
"required_block_count": 3
},
{
"page": 5,
"must_review_page": true,
"required_block_count": 10
}
]
}

2462
audit/2AGGSMVQ/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

134
audit/2AGGSMVQ/block_trace.csv Normal file
View file

@ -0,0 +1,134 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,doc_title,A Pulsing Electric Field (PEF) Increases Human Chondrocyte Proliferation through a Transduction Pathway Involving Nitric Oxide Signaling,"[66.0, 64.0, 1077.0, 139.0]",paper_title,0.8,"[""page-1 zone title_zone: A Pulsing Electric Field (PEF) Increases Human Chondrocyte P""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True
1,1,text,"Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ James Kronberg, $ ^{2} $ Timothy Ganey, $ ^{3} $ Arthur A. Pilla $ ^{4} $","[67.0, 170.0, 833.0, 195.0]",frontmatter_noise,0.7,"[""keyword-like block: Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ ""]",frontmatter_noise,0.7,body_zone,reference_like,citation_line,False,False
1,2,text," $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite E, Loma Linda, California 92354, $ ^{2} $Healthonics, Inc., Atlanta, Georgia, $ ^{3} $Department of Orthopedic Surgery, Atlanta Medical C","[66.0, 207.0, 1079.0, 269.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,3,text,Received 12 June 2007; accepted 18 October 2007,"[66.0, 278.0, 416.0, 298.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received 12 June 2007; accepted 18 October 2007""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,4,text,Published online 31 January 2008 in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jor.20590,"[66.0, 298.0, 839.0, 318.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Published online 31 January 2008 in Wiley InterScience (www.""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,5,abstract,"ABSTRACT: A potential treatment modality for joint pain due to cartilage degradation is electromagnetic fields (EMF) that can be delivered, noninvasively, to chondrocytes buried within cartilage. A pu","[67.0, 333.0, 1080.0, 614.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,6,text,Keywords: pulsing electric field; chondrocytes; DNA content; nitric oxide; cGMP,"[67.0, 628.0, 686.0, 650.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: pulsing electric field; chondrocytes; DNA content;""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,7,text,"To provide patients with more treatment options for pain management, especially as the population ages, there is a growing need for new methods, drugs, and devices. $ ^{1} $ Joint pain due to injury, ","[66.0, 691.0, 558.0, 828.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,8,text,Cartilage tissue has limited capacity for repair following injury. Untreated defects in the cartilage layer of a joint heal poorly or do not heal at all. The tissue degradation that ensues leads inevi,"[65.0, 829.0, 559.0, 1034.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,9,text,"Noninvasive electromagnetic fields have been shown to reduce musculoskeletal pain and edema with no known side effects. $ ^{5} $ Recently, a capacitively coupled pulsing electric field (PEF) signal ha","[65.0, 1034.0, 559.0, 1309.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,10,text,It is well known that PEMF signals of the type produced by BGS devices can have a physiologically significant effect on tissue growth and repair in animal studies $ ^{7} $ and human clinical trials. $,"[65.0, 1310.0, 560.0, 1381.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,11,text,"studies7 and human clinical trials.8 Based on these
reports it was hypothesized that PEF signals may be able
to modulate chondrocyte proliferation. It is thus the
primary intent of this study to test ","[583.0, 688.0, 1079.0, 805.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,12,text,It was considered equally important to determine a possible biological pathway by which the PEF signal could exert its action on chondrocytes. This would help establish a set of criteria by which prop,"[583.0, 806.0, 1080.0, 1105.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,13,paragraph_title,MATERIALS AND METHODS,"[586.0, 1126.0, 864.0, 1148.0]",section_heading,0.9,"[""explicit scholarly heading: MATERIALS AND METHODS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
1,14,text,"Majority of reagents were purchased from Sigma (St. Louis, MO) such as culture media (DMEM, #MT10013CV), calf serum (#B14-401F), and L-NAME (#72760) for inhibition of nitric oxide synthase, LY82583 (#","[583.0, 1150.0, 1078.0, 1341.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,15,paragraph_title,Cell Culture,"[585.0, 1363.0, 691.0, 1383.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Cell Culture""]",section_heading,0.5,body_zone,body_like,short_fragment,True,True
1,16,text,"Normal human chondrocytes (#CC2550) were obtained from Clonetics subdivision of Lonza (Walkersville, MD). Chondrocytes were grown for expansion in 100-mm culture dishes using DMEM supplemented with 5%","[583.0, 1384.0, 1079.0, 1471.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,17,footnote,Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909-478-9015; E-mail: biocore1@aol.com),"[66.0, 1406.0, 558.0, 1446.0]",frontmatter_support,0.75,"[""page-1 correspondence footnote: Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909""]",frontmatter_support,0.75,body_zone,body_like,none,True,True
1,18,footnote,"© 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.","[68.0, 1449.0, 559.0, 1471.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: \u00a9 2008 Orthopaedic Research Society. Published by Wiley Peri""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False
1,19,number,854,"[69.0, 1478.0, 105.0, 1497.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
1,20,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[131.0, 1479.0, 472.0, 1500.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
2,0,header,PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION,"[444.0, 68.0, 1056.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
2,1,number,855,"[1083.0, 68.0, 1118.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False
2,2,text,"calf serum). For experiments, chondrocytes were detached using trypsin, pooled into a single aliquot, counted, and then separated into culture wells using DMEM containing 0.1% calf serum. The use of 0","[106.0, 117.0, 601.0, 496.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,3,paragraph_title,Cell Proliferation,"[108.0, 514.0, 252.0, 534.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell Proliferation""]",subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,False,True
2,4,text,"DNA content of cell layer was used as an index of cell number, and an increase in cell number was used as an indication of increased cell proliferation. The culture media was removed and the cell laye","[107.0, 535.0, 602.0, 685.0]",unknown_structural,0.8,"[""page-1 zone author_zone: DNA content of cell layer was used as an index of cell numbe""]",authors,0.8,body_zone,body_like,none,False,True
2,5,paragraph_title,Nitric Oxide Measurement,"[108.0, 706.0, 329.0, 727.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Nitric Oxide Measurement""]",subsection_heading,0.6,frontmatter_side_zone,support_like,none,True,True
2,6,text,Nitrite in culture media was measured as an index of nitric oxide levels using the Griess reaction. $ ^{12} $ An aliquot (250 $ \mu $L) of conditioned culture media was collected and measured for nit,"[107.0, 728.0, 600.0, 834.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,7,paragraph_title,cGMP Measurement,"[108.0, 854.0, 278.0, 873.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: cGMP Measurement""]",subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,False,True
2,8,text,The level of cGMP in the cell layer was measured using cGMP Enzyme Immunoassay Kit from Sigma (#CG200-1kt). The culture media was removed and the cell layer rinsed with PBS at 4°C. The cell layer was ,"[107.0, 873.0, 601.0, 1002.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,9,paragraph_title,PEF Signal,"[108.0, 1023.0, 198.0, 1044.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: PEF Signal""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True
2,10,text,"The PEF signal (MedRelief® model SE55, Healthonics Inc, Atlanta, GA) is characterized by a pulse-burst waveform with a primary signal of asymmetrical biphasic rectangular pulses, 210/30 $ \mu $s in e","[106.0, 1045.0, 601.0, 1318.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,11,paragraph_title,Application of PEF Signal to Cell Culture,"[109.0, 1342.0, 436.0, 1363.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Application of PEF Signal to Cell Culture""]",subsection_heading,0.6,body_zone,body_like,none,True,True
2,12,text,"The PEF signal was delivered by capacitive coupling to chondrocytes using a novel replacement for traditional salt bridges. $ ^{13} $ In this new system, niobium wire jumpers were used instead of salt","[107.0, 1362.0, 602.0, 1470.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,13,text,"is closely controllable. The resulting vivid, nonfading light
interference colors are used in jewelry, and jeweler’s niobium
is manufactured in standard colors. Importantly for this
application, the h","[625.0, 117.0, 1121.0, 325.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,14,text,Niobium wire is cut and bent to form bridges between culture wells and the PEF signal passes through these bridges capacitively. Multiple wells are joined together in series. The wire is formed to fit,"[625.0, 326.0, 1120.0, 493.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,15,text,Preliminary studies found no indication of cytotoxicity when the PEF signal was delivered to either osteoblasts or chondrocytes via the niobium bridge. No changes in temperature or pH were detected in,"[625.0, 494.0, 1121.0, 641.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,16,paragraph_title,Statistics,"[627.0, 660.0, 706.0, 680.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Statistics""]",sub_subsection_heading,0.6,frontmatter_side_zone,support_like,short_fragment,True,True
2,17,text,For all measures the average value and standard deviation are reported. Number of samples per group was six. Data is expressed as percent of control values. Multiple control bars in a graph indicate c,"[624.0, 682.0, 1122.0, 1061.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: For all measures the average value and standard deviation ar""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False
2,18,paragraph_title,RESULTS,"[628.0, 1081.0, 720.0, 1104.0]",section_heading,0.9,"[""explicit scholarly heading: RESULTS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
2,19,text,The experimental design was to first investigate whether PEF had an effect on chondrocyte DNA content measured 72 h after PEF treatment. The experimental design then focused on changes in second messe,"[625.0, 1105.0, 1120.0, 1292.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,20,paragraph_title,Effect of Stimuli on Chondrocytes after 72 Hours,"[627.0, 1309.0, 1043.0, 1331.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of Stimuli on Chondrocytes after 72 Hours""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
2,21,text,A single 30-min treatment period to PEF with an amplitude producing 2.7 microamperes across culture media and an electric field of 0.2 mV/cm significantly increased DNA content by $ 133 \pm 10\% $ (p,"[625.0, 1332.0, 1120.0, 1471.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,22,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[781.0, 1496.0, 1119.0, 1515.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
3,0,number,856,"[68.0, 68.0, 105.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,1,header,FITZSIMMONS ET AL.,"[135.0, 67.0, 316.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,2,chart,,"[80.0, 116.0, 546.0, 434.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,3,figure_title,"Figure 1. Effect on DNA content after 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In the graph above, PEF signal was ","[66.0, 446.0, 559.0, 628.0]",figure_caption,0.92,"[""figure_title label: Figure 1. Effect on DNA content after 72 h. Normal human cho""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
3,4,text,"Insulin-like growth factor 1 and added calf serum (increases calf serum from 0.1 to 1.0%) also increased DNA content, as shown in Figure 1. A dose response to IGF1 showed higher concentrations (up to ","[66.0, 644.0, 558.0, 783.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,5,paragraph_title,Effect of PEF Treatment on Short-Term NO Release,"[67.0, 806.0, 500.0, 827.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of PEF Treatment on Short-Term NO Release""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
3,6,text,In preliminary studies it was found that PEF could increase NO content transiently within 30 min of initiation of PEF treatment and the elevated NO levels would typically return to control levels shor,"[65.0, 826.0, 559.0, 988.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,7,text,"To determine pathways involved in response to PEF treatment, chondrocytes were PEF treated in experiments with and without inhibitors. As shown in Figure 2, PEF treatment increased NO levels when meas","[65.0, 988.0, 559.0, 1217.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,8,text,In another series of experiments adding either 0.5 mM $ CaCl_{2} $ to the culture media or the calcium ionophore A23187 to 1 mM and measuring NO content of culture media 30 min later showed an increa,"[65.0, 1218.0, 559.0, 1379.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,9,text,"Effect of PEF Treatment on Short-Term cGMP Generation Nitric oxide acts as a second messenger for the activation of guanylate cyclase (15). Therefore, cGMP was","[66.0, 1401.0, 559.0, 1472.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,10,chart,,"[598.0, 114.0, 1063.0, 493.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,11,figure_title,Figure 2. PEF signal and short-term (30 min) NO release. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (lig,"[584.0, 503.0, 1079.0, 744.0]",figure_caption,0.92,"[""figure_title label: Figure 2. PEF signal and short-term (30 min) NO release. Nor""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
3,12,text,"measured in the cell layer after PEF treatment. As shown in Figure 3, PEF treatment increased cGMP within the 30-min treatment period. This effect was blocked by either W7 or by L-NAME, as expected if","[583.0, 772.0, 1081.0, 865.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,13,chart,,"[598.0, 887.0, 1063.0, 1262.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,14,figure_title,Figure 3. PEF signal increases short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf-serum and allowed to attach and equilibrate for 24 h. In one expe,"[584.0, 1274.0, 1079.0, 1470.0]",figure_caption,0.92,"[""figure_title label: Figure 3. PEF signal increases short-term (30 min) cGMP gene""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
3,15,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[68.0, 1498.0, 406.0, 1517.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
4,0,header,PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION,"[445.0, 67.0, 1056.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
4,1,number,857,"[1083.0, 68.0, 1118.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,2,chart,,"[122.0, 115.0, 585.0, 442.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,3,figure_title,Figure 4. PEF signal and SNP increase short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. The ,"[107.0, 455.0, 601.0, 650.0]",figure_caption,0.92,"[""figure_title label: Figure 4. PEF signal and SNP increase short-term (30 min) cG""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
4,4,text,cGMP was increased in a cascade from calmodulin to nitric oxide synthase to cGMP.,"[107.0, 713.0, 600.0, 758.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,5,text,"In Figure 4, both PEF and a nitric oxide donor (SNP) increased cGMP content of the cell layer within 30 min of treatment. The guanylate cyclase inhibitor (LY83583) blocked both PEF treatment and SNP f","[107.0, 759.0, 601.0, 967.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,6,paragraph_title,Effect of Inhibitors on Ability of PEF Treatment to Increase DNA Content at 72 Hours,"[108.0, 991.0, 527.0, 1034.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Effect of Inhibitors on Ability of PEF Treatment to Increase""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
4,7,text,"In Figure 5, PEF treatment, when applied one time for 30 min, increased chondrocyte proliferation as observed in previous experiments. When L-NAME was added prior to PEF treatment the increase in chon","[107.0, 1035.0, 600.0, 1195.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,8,text,"Effect of SNP on Chondrocyte Proliferation at 72 Hours
In Figure 6, SNP was added to a final concentration of 150 $ \mu $M, which increased nitric oxide content in culture media to 752 ± 74% of contr","[106.0, 1217.0, 602.0, 1470.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,9,chart,,"[640.0, 117.0, 1106.0, 476.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,10,figure_title,Figure 5. PEF signal and increased DNA content at 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (ligh,"[627.0, 486.0, 1121.0, 687.0]",figure_caption,0.92,"[""figure_title label: Figure 5. PEF signal and increased DNA content at 72 h. Norm""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
4,11,text,"content when present for 30 min, which is similar to the profile of NO release with PEF alone.","[626.0, 713.0, 1120.0, 760.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,12,paragraph_title,DISCUSSION,"[629.0, 781.0, 762.0, 803.0]",section_heading,0.9,"[""explicit scholarly heading: DISCUSSION""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
4,13,text,Normal tissue regeneration proceeds through a series of phases starting with inflammation $ ^{16} $ and culminating in the deposition and organization of new tissue. In the,"[626.0, 805.0, 1122.0, 875.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,14,chart,,"[639.0, 895.0, 1105.0, 1259.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,15,figure_title,Figure 6. SNP and PEF effects on DNA. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. Cultures were treated to SNP (an NO donor,"[625.0, 1274.0, 1120.0, 1469.0]",figure_caption,0.92,"[""figure_title label: Figure 6. SNP and PEF effects on DNA. Normal human chondrocy""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
4,16,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[782.0, 1497.0, 1119.0, 1515.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
5,0,number,858,"[69.0, 68.0, 104.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,1,header,FITZSIMMONS ET AL.,"[135.0, 68.0, 317.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,2,text,"case of chronic joint pain, whether due to a prior injury or osteoarthritis, tissue regeneration stalls indefinitely in the inflammation phase. This leads to progressive degeneration of cartilage, irr","[65.0, 117.0, 559.0, 255.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,3,text,"Cartilage degradation in itself does not translate as a sensory perception directly from the cartilage; joint pain is the symptom that causes patients to seek treatment. Unfortunately, treatments aime","[65.0, 256.0, 559.0, 622.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,4,text,"This study utilized a PEF signal adapted from the signal used in bone growth stimulators, employed successfully for recalcitrant bone fractures. $ ^{17} $ There are a number of similarities between th","[66.0, 622.0, 558.0, 1034.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,5,text,The results of this study also suggest that release of NO is part of the biologic pathway involved in increased DNA content of chondrocyte cultures following PEF treatment. NO increased within the 30-,"[65.0, 1035.0, 559.0, 1287.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
5,6,text,"Nitric oxide has many influences, $ ^{16,21} $ of which one can be activation of guanylate cyclase, which produces cGMP. $ ^{15} $ This study showed that the PEF signal increased cGMP within the 30-mi","[65.0, 1286.0, 559.0, 1471.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
5,7,text,"cultures following PEF signal treatment was blocked by
LY83583, thereby indicating cGMP is involved in the
pathway of PEF-stimulated DNA content of chondrocyte
cultures.
I h i i i id l ld b","[583.0, 117.0, 1079.0, 209.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,8,text,"In these experiments nitric oxide release could be increased with added calcium or a calcium ionophore, which is consistent with reports that NOS can be regulated by calcium. $ ^{23} $ When the calmod","[583.0, 210.0, 1079.0, 415.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,9,text,"Taken together, the data indicates this PEF signal stimulates chondrocyte proliferation through a biological pathway that involves calcium/ calmodulin, nitric oxide synthase, nitric oxide, and cGMP. T","[583.0, 415.0, 1079.0, 759.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,10,text,"Whether this PEF signal can impart beneficial action to cartilage in human patients, of course, remains to be tested. One limitation of this study is the use of chondrocytes in cell culture, and the o","[583.0, 759.0, 1080.0, 1013.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,11,paragraph_title,ACKNOWLEDGMENTS,"[587.0, 1037.0, 811.0, 1059.0]",section_heading,0.6,"[""unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS""]",section_heading,0.6,body_zone,heading_like,short_fragment,True,True
5,12,text,"This study was partially funded, and the PEF generators were supplied, by Healthonics Inc., Altanta, GA.","[584.0, 1061.0, 1077.0, 1105.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,13,paragraph_title,REFERENCES,"[588.0, 1124.0, 714.0, 1146.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True
5,14,reference_content,"1. Felson D, Zhang Y. 1998. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 41:1343–1355.","[600.0, 1150.0, 1077.0, 1208.0]",reference_item,0.85,"[""reference content label: 1. Felson D, Zhang Y. 1998. An update on the epidemiology of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
5,15,reference_content,"2. Department of Health and Human Services. 1991. Aging America: trends and projections. DHHS publication number FC:AJp-28001. Washington, DC: DHHS.","[599.0, 1210.0, 1076.0, 1267.0]",reference_item,0.85,"[""reference content label: 2. Department of Health and Human Services. 1991. Aging Amer""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
5,16,reference_content,"3. Manek N, Lane N. 2000. Osteoarthritis: current concepts in diagnosis and management. Am Fam Phys 61:1795–1804.","[600.0, 1270.0, 1075.0, 1308.0]",reference_item,0.85,"[""reference content label: 3. Manek N, Lane N. 2000. Osteoarthritis: current concepts i""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
5,17,reference_content,4. Rubin B. 2005. Management of osteoarthritic knee pain. J Am Osteopath Assoc 105(Suppl):S23–S28.,"[599.0, 1309.0, 1076.0, 1347.0]",reference_item,0.85,"[""reference content label: 4. Rubin B. 2005. Management of osteoarthritic knee pain. J ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
5,18,reference_content,"5. Zizic T, Hoffman K, Holt P, et al. 1995. The treatment of osteoarthritis of the knee with pulsed electrical stimulation. J Rheumatol 22:1757–1761.","[600.0, 1349.0, 1077.0, 1407.0]",reference_item,0.85,"[""reference content label: 5. Zizic T, Hoffman K, Holt P, et al. 1995. The treatment of""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
5,19,reference_content,"6. Basset C, Pawluk R, Pilla A. 1974. Augmentation of bone repair by inductively coupled electromagnetic fields. Science 184:575–577.","[600.0, 1410.0, 1077.0, 1466.0]",reference_item,0.85,"[""reference content label: 6. Basset C, Pawluk R, Pilla A. 1974. Augmentation of bone r""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
5,20,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[67.0, 1498.0, 406.0, 1517.0]",noise,0.9,"[""footer label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False
6,0,header,PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION,"[445.0, 69.0, 1055.0, 88.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
6,1,number,859,"[1083.0, 69.0, 1118.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
6,2,reference_content,"7. Fredericks D, Nepola J, Baker J, et al. 2000. Effect of pulsed electromagnetic fields on bone healing in a rabbit tibial osteotomy model. J Orthop Trauma 14:93–100.","[123.0, 122.0, 599.0, 180.0]",reference_item,0.85,"[""reference content label: 7. Fredericks D, Nepola J, Baker J, et al. 2000. Effect of p""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,3,reference_content,"8. Akai M, Hayashi K. 2002. Effect of electrical stimulation on musculoskeletal systems: a meta-analysis of controlled clinical trials. Bioelectromagnetics 23:132–143.","[123.0, 182.0, 598.0, 239.0]",reference_item,0.85,"[""reference content label: 8. Akai M, Hayashi K. 2002. Effect of electrical stimulation""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,4,reference_content,"9. Diniz P, Soejima K, Ito G. 2002. Nitric oxide mediates the effects of pulsed electromagnetic field stimulation on the osteoblast proliferation and differentiation. Nitric Oxide 7:18–23.","[121.0, 242.0, 599.0, 299.0]",reference_item,0.85,"[""reference content label: 9. Diniz P, Soejima K, Ito G. 2002. Nitric oxide mediates th""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,5,reference_content,"10. Cheng J, Zhang C, Han JS, et al. 2007. TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues. Med Sci Monit 13:163–167.","[115.0, 301.0, 599.0, 358.0]",reference_item,0.85,"[""reference content label: 10. Cheng J, Zhang C, Han JS, et al. 2007. TENS stimulates c""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,6,reference_content,"11. Van Susante JL, Buma P, Van Beuningen HM, et al. 2000. Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentrations. J Orthop Res 18:68–77.","[115.0, 361.0, 598.0, 438.0]",reference_item,0.85,"[""reference content label: 11. Van Susante JL, Buma P, Van Beuningen HM, et al. 2000. R""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,7,reference_content,"12. Guevara I, Iwanejko J, Dembinska-Kiec A, et al. 1998. Determination of nitrite/nitrate in human biological material by the simple Griess reaction. Clin Chim Acta 274:177–188.","[115.0, 442.0, 598.0, 517.0]",reference_item,0.85,"[""reference content label: 12. Guevara I, Iwanejko J, Dembinska-Kiec A, et al. 1998. De""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,8,reference_content,"13. Kronberg J, Ganey T, Fitzsimmons R. 2006. A novel niobium salt bridge for in vitro PEMF studies. 28th annual meeting, Bioelectromagnetics Society, abstract 11–5.","[114.0, 521.0, 598.0, 578.0]",reference_item,0.85,"[""reference content label: 13. Kronberg J, Ganey T, Fitzsimmons R. 2006. A novel niobiu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,9,reference_content,"14. Ganey T. Personal communication, May 2006.","[116.0, 579.0, 491.0, 598.0]",reference_item,0.85,"[""reference content label: 14. Ganey T. Personal communication, May 2006.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,10,reference_content,"15. Knowles R, Palacios M, Palmer R, et al. 1989 Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Pro","[116.0, 601.0, 599.0, 678.0]",reference_item,0.85,"[""reference content label: 15. Knowles R, Palacios M, Palmer R, et al. 1989 Formation o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,11,reference_content,16. Brooks P. 2003. Inflammation as an important feature of osteoarthritis. Bull World Health Organ 81:689–690.,"[115.0, 680.0, 599.0, 718.0]",reference_item,0.85,"[""reference content label: 16. Brooks P. 2003. Inflammation as an important feature of ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,12,reference_content,"17. Pilla A. 2006. Mechanisms and therapeutic applications of time varying and static magnetic fields. In: Barnes F, Greenebaum B, editors. Biological and medical aspects of electromagnetic fields. Bo","[115.0, 721.0, 599.0, 798.0]",reference_item,0.85,"[""reference content label: 17. Pilla A. 2006. Mechanisms and therapeutic applications o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,13,reference_content,"18. DeMattei M, Caruso A, Pezzetti F, et al. 2001. Effects of pulsed electromagnetic fields on human articular chondrocyte proliferation. Connect Tissue Res 42:1–11.","[634.0, 122.0, 1119.0, 180.0]",reference_item,0.85,"[""reference content label: 18. DeMattei M, Caruso A, Pezzetti F, et al. 2001. Effects o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,14,reference_content,"19. Fioravanti A, Nerucci F, Collodel G, et al. 2002. Biochemical and morphological study of human articular chondrocytes cultivated in the presence of pulsed signal therapy. Ann Rheum Dis 61:1032–103","[635.0, 182.0, 1118.0, 259.0]",reference_item,0.85,"[""reference content label: 19. Fioravanti A, Nerucci F, Collodel G, et al. 2002. Bioche""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,15,reference_content,"20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression of neuronal nitric oxide synthase and phospholipase C- $ \gamma $1 in regenerating murine neuronal cells by pulsed electromagnetic field. Exp","[633.0, 262.0, 1118.0, 338.0]",reference_item,0.85,"[""reference content label: 20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,16,reference_content,"21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric oxide and wound repair: role of cytokines. Nitric Oxide 7:1–10.","[632.0, 341.0, 1117.0, 379.0]",reference_item,0.85,"[""reference content label: 21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,17,reference_content,"22. Miura M, Takayama K, Okada J. 1993. Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation. J Physiol 461:513–524.","[633.0, 381.0, 1118.0, 439.0]",reference_item,0.85,"[""reference content label: 22. Miura M, Takayama K, Okada J. 1993. Increase in nitric o""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,18,reference_content,"23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J B","[633.0, 442.0, 1119.0, 537.0]",reference_item,0.85,"[""reference content label: 23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxid""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,19,reference_content,"24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/ligand binding kinetics: prediction of bioeffective waveform parameters. Bioelectrochem Bioenerg 48:27–34.","[633.0, 541.0, 1118.0, 598.0]",reference_item,0.85,"[""reference content label: 24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,20,reference_content,"25. Markov MS, Pilla AA. 1997. Weak static magnetic field modulation of myosin phosphorylation in a cell-free preparation: calcium dependence. Bioelectrochem Bioenergetics 43:235–240.","[633.0, 601.0, 1118.0, 676.0]",reference_item,0.85,"[""reference content label: 25. Markov MS, Pilla AA. 1997. Weak static magnetic field mo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,21,reference_content,"26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transduction in electrically stimulated bone cells. J Bone Joint Surg 83-A:1514–1523.","[633.0, 681.0, 1118.0, 737.0]",reference_item,0.85,"[""reference content label: 26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transd""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,22,reference_content,"27. Ciombor DM, Lester G, Aaron RK, et al. 2002. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. J Orthop Res 20:40–50.","[632.0, 741.0, 1120.0, 798.0]",reference_item,0.85,"[""reference content label: 27. Ciombor DM, Lester G, Aaron RK, et al. 2002. Low frequen""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
6,23,footer,JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008,"[781.0, 1497.0, 1118.0, 1515.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 doc_title A Pulsing Electric Field (PEF) Increases Human Chondrocyte Proliferation through a Transduction Pathway Involving Nitric Oxide Signaling [66.0, 64.0, 1077.0, 139.0] paper_title 0.8 ["page-1 zone title_zone: A Pulsing Electric Field (PEF) Increases Human Chondrocyte P"] paper_title 0.8 frontmatter_main_zone support_like none True True
3 1 1 text Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ James Kronberg, $ ^{2} $ Timothy Ganey, $ ^{3} $ Arthur A. Pilla $ ^{4} $ [67.0, 170.0, 833.0, 195.0] frontmatter_noise 0.7 ["keyword-like block: Robert J. Fitzsimmons, $ ^{1} $ Stephen L. Gordon, $ ^{2} $ "] frontmatter_noise 0.7 body_zone reference_like citation_line False False
4 1 2 text $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite E, Loma Linda, California 92354, $ ^{2} $Healthonics, Inc., Atlanta, Georgia, $ ^{3} $Department of Orthopedic Surgery, Atlanta Medical C [66.0, 207.0, 1079.0, 269.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{1} $The Technical Basis LLC, 24769 Redlands Blvd, Suite "] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
5 1 3 text Received 12 June 2007; accepted 18 October 2007 [66.0, 278.0, 416.0, 298.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Received 12 June 2007; accepted 18 October 2007"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
6 1 4 text Published online 31 January 2008 in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jor.20590 [66.0, 298.0, 839.0, 318.0] frontmatter_noise 0.7 ["frontmatter noise text: Published online 31 January 2008 in Wiley InterScience (www."] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
7 1 5 abstract ABSTRACT: A potential treatment modality for joint pain due to cartilage degradation is electromagnetic fields (EMF) that can be delivered, noninvasively, to chondrocytes buried within cartilage. A pu [67.0, 333.0, 1080.0, 614.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
8 1 6 text Keywords: pulsing electric field; chondrocytes; DNA content; nitric oxide; cGMP [67.0, 628.0, 686.0, 650.0] frontmatter_noise 0.7 ["frontmatter noise text: Keywords: pulsing electric field; chondrocytes; DNA content;"] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
9 1 7 text To provide patients with more treatment options for pain management, especially as the population ages, there is a growing need for new methods, drugs, and devices. $ ^{1} $ Joint pain due to injury, [66.0, 691.0, 558.0, 828.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
10 1 8 text Cartilage tissue has limited capacity for repair following injury. Untreated defects in the cartilage layer of a joint heal poorly or do not heal at all. The tissue degradation that ensues leads inevi [65.0, 829.0, 559.0, 1034.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
11 1 9 text Noninvasive electromagnetic fields have been shown to reduce musculoskeletal pain and edema with no known side effects. $ ^{5} $ Recently, a capacitively coupled pulsing electric field (PEF) signal ha [65.0, 1034.0, 559.0, 1309.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
12 1 10 text It is well known that PEMF signals of the type produced by BGS devices can have a physiologically significant effect on tissue growth and repair in animal studies $ ^{7} $ and human clinical trials. $ [65.0, 1310.0, 560.0, 1381.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
13 1 11 text studies7 and human clinical trials.8 Based on these reports it was hypothesized that PEF signals may be able to modulate chondrocyte proliferation. It is thus the primary intent of this study to test [583.0, 688.0, 1079.0, 805.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
14 1 12 text It was considered equally important to determine a possible biological pathway by which the PEF signal could exert its action on chondrocytes. This would help establish a set of criteria by which prop [583.0, 806.0, 1080.0, 1105.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
15 1 13 paragraph_title MATERIALS AND METHODS [586.0, 1126.0, 864.0, 1148.0] section_heading 0.9 ["explicit scholarly heading: MATERIALS AND METHODS"] section_heading 0.9 body_zone heading_like canonical_section_name True True
16 1 14 text Majority of reagents were purchased from Sigma (St. Louis, MO) such as culture media (DMEM, #MT10013CV), calf serum (#B14-401F), and L-NAME (#72760) for inhibition of nitric oxide synthase, LY82583 (# [583.0, 1150.0, 1078.0, 1341.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
17 1 15 paragraph_title Cell Culture [585.0, 1363.0, 691.0, 1383.0] section_heading 0.5 ["unnumbered paragraph_title on page 1 outside title zone: Cell Culture"] section_heading 0.5 body_zone body_like short_fragment True True
18 1 16 text Normal human chondrocytes (#CC2550) were obtained from Clonetics subdivision of Lonza (Walkersville, MD). Chondrocytes were grown for expansion in 100-mm culture dishes using DMEM supplemented with 5% [583.0, 1384.0, 1079.0, 1471.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
19 1 17 footnote Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909-478-9015; E-mail: biocore1@aol.com) [66.0, 1406.0, 558.0, 1446.0] frontmatter_support 0.75 ["page-1 correspondence footnote: Correspondence to: R.J. Fitzsimmons (T: 909-478-9085; F: 909"] frontmatter_support 0.75 body_zone body_like none True True
20 1 18 footnote © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. [68.0, 1449.0, 559.0, 1471.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: \u00a9 2008 Orthopaedic Research Society. Published by Wiley Peri"] frontmatter_noise 0.8 body_zone body_like none False False
21 1 19 number 854 [69.0, 1478.0, 105.0, 1497.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
22 1 20 footer JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008 [131.0, 1479.0, 472.0, 1500.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
23 2 0 header PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION [444.0, 68.0, 1056.0, 88.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
24 2 1 number 855 [1083.0, 68.0, 1118.0, 87.0] noise 0.9 ["page number label"] noise 0.9 frontmatter_side_zone support_like short_fragment False False
25 2 2 text calf serum). For experiments, chondrocytes were detached using trypsin, pooled into a single aliquot, counted, and then separated into culture wells using DMEM containing 0.1% calf serum. The use of 0 [106.0, 117.0, 601.0, 496.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
26 2 3 paragraph_title Cell Proliferation [108.0, 514.0, 252.0, 534.0] unknown_structural 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Cell Proliferation"] subsection_heading 0.6 frontmatter_side_zone support_like short_fragment False True
27 2 4 text DNA content of cell layer was used as an index of cell number, and an increase in cell number was used as an indication of increased cell proliferation. The culture media was removed and the cell laye [107.0, 535.0, 602.0, 685.0] unknown_structural 0.8 ["page-1 zone author_zone: DNA content of cell layer was used as an index of cell numbe"] authors 0.8 body_zone body_like none False True
28 2 5 paragraph_title Nitric Oxide Measurement [108.0, 706.0, 329.0, 727.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Nitric Oxide Measurement"] subsection_heading 0.6 frontmatter_side_zone support_like none True True
29 2 6 text Nitrite in culture media was measured as an index of nitric oxide levels using the Griess reaction. $ ^{12} $ An aliquot (250 $ \mu $L) of conditioned culture media was collected and measured for nit [107.0, 728.0, 600.0, 834.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
30 2 7 paragraph_title cGMP Measurement [108.0, 854.0, 278.0, 873.0] unknown_structural 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: cGMP Measurement"] subsection_heading 0.6 frontmatter_side_zone support_like short_fragment False True
31 2 8 text The level of cGMP in the cell layer was measured using cGMP Enzyme Immunoassay Kit from Sigma (#CG200-1kt). The culture media was removed and the cell layer rinsed with PBS at 4°C. The cell layer was [107.0, 873.0, 601.0, 1002.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
32 2 9 paragraph_title PEF Signal [108.0, 1023.0, 198.0, 1044.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: PEF Signal"] subsection_heading 0.6 body_zone body_like short_fragment True True
33 2 10 text The PEF signal (MedRelief® model SE55, Healthonics Inc, Atlanta, GA) is characterized by a pulse-burst waveform with a primary signal of asymmetrical biphasic rectangular pulses, 210/30 $ \mu $s in e [106.0, 1045.0, 601.0, 1318.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
34 2 11 paragraph_title Application of PEF Signal to Cell Culture [109.0, 1342.0, 436.0, 1363.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Application of PEF Signal to Cell Culture"] subsection_heading 0.6 body_zone body_like none True True
35 2 12 text The PEF signal was delivered by capacitive coupling to chondrocytes using a novel replacement for traditional salt bridges. $ ^{13} $ In this new system, niobium wire jumpers were used instead of salt [107.0, 1362.0, 602.0, 1470.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
36 2 13 text is closely controllable. The resulting vivid, nonfading light interference colors are used in jewelry, and jeweler’s niobium is manufactured in standard colors. Importantly for this application, the h [625.0, 117.0, 1121.0, 325.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
37 2 14 text Niobium wire is cut and bent to form bridges between culture wells and the PEF signal passes through these bridges capacitively. Multiple wells are joined together in series. The wire is formed to fit [625.0, 326.0, 1120.0, 493.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
38 2 15 text Preliminary studies found no indication of cytotoxicity when the PEF signal was delivered to either osteoblasts or chondrocytes via the niobium bridge. No changes in temperature or pH were detected in [625.0, 494.0, 1121.0, 641.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
39 2 16 paragraph_title Statistics [627.0, 660.0, 706.0, 680.0] sub_subsection_heading 0.6 ["unnumbered paragraph_title, inferred level sub_subsection_heading: Statistics"] sub_subsection_heading 0.6 frontmatter_side_zone support_like short_fragment True True
40 2 17 text For all measures the average value and standard deviation are reported. Number of samples per group was six. Data is expressed as percent of control values. Multiple control bars in a graph indicate c [624.0, 682.0, 1122.0, 1061.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: For all measures the average value and standard deviation ar"] frontmatter_noise 0.8 body_zone body_like none False False
41 2 18 paragraph_title RESULTS [628.0, 1081.0, 720.0, 1104.0] section_heading 0.9 ["explicit scholarly heading: RESULTS"] section_heading 0.9 body_zone heading_like canonical_section_name True True
42 2 19 text The experimental design was to first investigate whether PEF had an effect on chondrocyte DNA content measured 72 h after PEF treatment. The experimental design then focused on changes in second messe [625.0, 1105.0, 1120.0, 1292.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
43 2 20 paragraph_title Effect of Stimuli on Chondrocytes after 72 Hours [627.0, 1309.0, 1043.0, 1331.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Effect of Stimuli on Chondrocytes after 72 Hours"] subsection_heading 0.6 body_zone heading_like none True True
44 2 21 text A single 30-min treatment period to PEF with an amplitude producing 2.7 microamperes across culture media and an electric field of 0.2 mV/cm significantly increased DNA content by $ 133 \pm 10\% $ (p [625.0, 1332.0, 1120.0, 1471.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
45 2 22 footer JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008 [781.0, 1496.0, 1119.0, 1515.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
46 3 0 number 856 [68.0, 68.0, 105.0, 87.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
47 3 1 header FITZSIMMONS ET AL. [135.0, 67.0, 316.0, 88.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
48 3 2 chart [80.0, 116.0, 546.0, 434.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
49 3 3 figure_title Figure 1. Effect on DNA content after 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In the graph above, PEF signal was [66.0, 446.0, 559.0, 628.0] figure_caption 0.92 ["figure_title label: Figure 1. Effect on DNA content after 72 h. Normal human cho"] figure_caption 0.92 display_zone legend_like figure_number True True
50 3 4 text Insulin-like growth factor 1 and added calf serum (increases calf serum from 0.1 to 1.0%) also increased DNA content, as shown in Figure 1. A dose response to IGF1 showed higher concentrations (up to [66.0, 644.0, 558.0, 783.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
51 3 5 paragraph_title Effect of PEF Treatment on Short-Term NO Release [67.0, 806.0, 500.0, 827.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Effect of PEF Treatment on Short-Term NO Release"] subsection_heading 0.6 body_zone heading_like none True True
52 3 6 text In preliminary studies it was found that PEF could increase NO content transiently within 30 min of initiation of PEF treatment and the elevated NO levels would typically return to control levels shor [65.0, 826.0, 559.0, 988.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
53 3 7 text To determine pathways involved in response to PEF treatment, chondrocytes were PEF treated in experiments with and without inhibitors. As shown in Figure 2, PEF treatment increased NO levels when meas [65.0, 988.0, 559.0, 1217.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
54 3 8 text In another series of experiments adding either 0.5 mM $ CaCl_{2} $ to the culture media or the calcium ionophore A23187 to 1 mM and measuring NO content of culture media 30 min later showed an increa [65.0, 1218.0, 559.0, 1379.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
55 3 9 text Effect of PEF Treatment on Short-Term cGMP Generation Nitric oxide acts as a second messenger for the activation of guanylate cyclase (15). Therefore, cGMP was [66.0, 1401.0, 559.0, 1472.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
56 3 10 chart [598.0, 114.0, 1063.0, 493.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
57 3 11 figure_title Figure 2. PEF signal and short-term (30 min) NO release. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (lig [584.0, 503.0, 1079.0, 744.0] figure_caption 0.92 ["figure_title label: Figure 2. PEF signal and short-term (30 min) NO release. Nor"] figure_caption 0.92 display_zone legend_like figure_number True True
58 3 12 text measured in the cell layer after PEF treatment. As shown in Figure 3, PEF treatment increased cGMP within the 30-min treatment period. This effect was blocked by either W7 or by L-NAME, as expected if [583.0, 772.0, 1081.0, 865.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
59 3 13 chart [598.0, 887.0, 1063.0, 1262.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
60 3 14 figure_title Figure 3. PEF signal increases short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf-serum and allowed to attach and equilibrate for 24 h. In one expe [584.0, 1274.0, 1079.0, 1470.0] figure_caption 0.92 ["figure_title label: Figure 3. PEF signal increases short-term (30 min) cGMP gene"] figure_caption 0.92 display_zone legend_like figure_number True True
61 3 15 footer JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008 [68.0, 1498.0, 406.0, 1517.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
62 4 0 header PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION [445.0, 67.0, 1056.0, 88.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
63 4 1 number 857 [1083.0, 68.0, 1118.0, 87.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
64 4 2 chart [122.0, 115.0, 585.0, 442.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
65 4 3 figure_title Figure 4. PEF signal and SNP increase short-term (30 min) cGMP generation. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. The [107.0, 455.0, 601.0, 650.0] figure_caption 0.92 ["figure_title label: Figure 4. PEF signal and SNP increase short-term (30 min) cG"] figure_caption 0.92 display_zone legend_like figure_number True True
66 4 4 text cGMP was increased in a cascade from calmodulin to nitric oxide synthase to cGMP. [107.0, 713.0, 600.0, 758.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
67 4 5 text In Figure 4, both PEF and a nitric oxide donor (SNP) increased cGMP content of the cell layer within 30 min of treatment. The guanylate cyclase inhibitor (LY83583) blocked both PEF treatment and SNP f [107.0, 759.0, 601.0, 967.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
68 4 6 paragraph_title Effect of Inhibitors on Ability of PEF Treatment to Increase DNA Content at 72 Hours [108.0, 991.0, 527.0, 1034.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Effect of Inhibitors on Ability of PEF Treatment to Increase"] subsection_heading 0.6 body_zone heading_like none True True
69 4 7 text In Figure 5, PEF treatment, when applied one time for 30 min, increased chondrocyte proliferation as observed in previous experiments. When L-NAME was added prior to PEF treatment the increase in chon [107.0, 1035.0, 600.0, 1195.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
70 4 8 text Effect of SNP on Chondrocyte Proliferation at 72 Hours In Figure 6, SNP was added to a final concentration of 150 $ \mu $M, which increased nitric oxide content in culture media to 752 ± 74% of contr [106.0, 1217.0, 602.0, 1470.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
71 4 9 chart [640.0, 117.0, 1106.0, 476.0] media_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
72 4 10 figure_title Figure 5. PEF signal and increased DNA content at 72 h. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. In one experiment (ligh [627.0, 486.0, 1121.0, 687.0] figure_caption 0.92 ["figure_title label: Figure 5. PEF signal and increased DNA content at 72 h. Norm"] figure_caption 0.92 display_zone legend_like figure_number True True
73 4 11 text content when present for 30 min, which is similar to the profile of NO release with PEF alone. [626.0, 713.0, 1120.0, 760.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
74 4 12 paragraph_title DISCUSSION [629.0, 781.0, 762.0, 803.0] section_heading 0.9 ["explicit scholarly heading: DISCUSSION"] section_heading 0.9 body_zone heading_like canonical_section_name True True
75 4 13 text Normal tissue regeneration proceeds through a series of phases starting with inflammation $ ^{16} $ and culminating in the deposition and organization of new tissue. In the [626.0, 805.0, 1122.0, 875.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
76 4 14 chart [639.0, 895.0, 1105.0, 1259.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
77 4 15 figure_title Figure 6. SNP and PEF effects on DNA. Normal human chondrocytes were plated in DMEM containing 0.1% calf serum and allowed to attach and equilibrate for 24 h. Cultures were treated to SNP (an NO donor [625.0, 1274.0, 1120.0, 1469.0] figure_caption 0.92 ["figure_title label: Figure 6. SNP and PEF effects on DNA. Normal human chondrocy"] figure_caption 0.92 display_zone legend_like figure_number True True
78 4 16 footer JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008 [782.0, 1497.0, 1119.0, 1515.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
79 5 0 number 858 [69.0, 68.0, 104.0, 87.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
80 5 1 header FITZSIMMONS ET AL. [135.0, 68.0, 317.0, 88.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like short_fragment False False
81 5 2 text case of chronic joint pain, whether due to a prior injury or osteoarthritis, tissue regeneration stalls indefinitely in the inflammation phase. This leads to progressive degeneration of cartilage, irr [65.0, 117.0, 559.0, 255.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
82 5 3 text Cartilage degradation in itself does not translate as a sensory perception directly from the cartilage; joint pain is the symptom that causes patients to seek treatment. Unfortunately, treatments aime [65.0, 256.0, 559.0, 622.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
83 5 4 text This study utilized a PEF signal adapted from the signal used in bone growth stimulators, employed successfully for recalcitrant bone fractures. $ ^{17} $ There are a number of similarities between th [66.0, 622.0, 558.0, 1034.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
84 5 5 text The results of this study also suggest that release of NO is part of the biologic pathway involved in increased DNA content of chondrocyte cultures following PEF treatment. NO increased within the 30- [65.0, 1035.0, 559.0, 1287.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none True True
85 5 6 text Nitric oxide has many influences, $ ^{16,21} $ of which one can be activation of guanylate cyclase, which produces cGMP. $ ^{15} $ This study showed that the PEF signal increased cGMP within the 30-mi [65.0, 1286.0, 559.0, 1471.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none True True
86 5 7 text cultures following PEF signal treatment was blocked by LY83583, thereby indicating cGMP is involved in the pathway of PEF-stimulated DNA content of chondrocyte cultures. I h i i i id l ld b [583.0, 117.0, 1079.0, 209.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
87 5 8 text In these experiments nitric oxide release could be increased with added calcium or a calcium ionophore, which is consistent with reports that NOS can be regulated by calcium. $ ^{23} $ When the calmod [583.0, 210.0, 1079.0, 415.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
88 5 9 text Taken together, the data indicates this PEF signal stimulates chondrocyte proliferation through a biological pathway that involves calcium/ calmodulin, nitric oxide synthase, nitric oxide, and cGMP. T [583.0, 415.0, 1079.0, 759.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
89 5 10 text Whether this PEF signal can impart beneficial action to cartilage in human patients, of course, remains to be tested. One limitation of this study is the use of chondrocytes in cell culture, and the o [583.0, 759.0, 1080.0, 1013.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
90 5 11 paragraph_title ACKNOWLEDGMENTS [587.0, 1037.0, 811.0, 1059.0] section_heading 0.6 ["unnumbered paragraph_title, inferred level section_heading: ACKNOWLEDGMENTS"] section_heading 0.6 body_zone heading_like short_fragment True True
91 5 12 text This study was partially funded, and the PEF generators were supplied, by Healthonics Inc., Altanta, GA. [584.0, 1061.0, 1077.0, 1105.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
92 5 13 paragraph_title REFERENCES [588.0, 1124.0, 714.0, 1146.0] reference_heading 0.9 ["references heading: REFERENCES"] reference_heading 0.9 reference_zone heading_like short_fragment True True
93 5 14 reference_content 1. Felson D, Zhang Y. 1998. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 41:1343–1355. [600.0, 1150.0, 1077.0, 1208.0] reference_item 0.85 ["reference content label: 1. Felson D, Zhang Y. 1998. An update on the epidemiology of"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
94 5 15 reference_content 2. Department of Health and Human Services. 1991. Aging America: trends and projections. DHHS publication number FC:AJp-28001. Washington, DC: DHHS. [599.0, 1210.0, 1076.0, 1267.0] reference_item 0.85 ["reference content label: 2. Department of Health and Human Services. 1991. Aging Amer"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
95 5 16 reference_content 3. Manek N, Lane N. 2000. Osteoarthritis: current concepts in diagnosis and management. Am Fam Phys 61:1795–1804. [600.0, 1270.0, 1075.0, 1308.0] reference_item 0.85 ["reference content label: 3. Manek N, Lane N. 2000. Osteoarthritis: current concepts i"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
96 5 17 reference_content 4. Rubin B. 2005. Management of osteoarthritic knee pain. J Am Osteopath Assoc 105(Suppl):S23–S28. [599.0, 1309.0, 1076.0, 1347.0] reference_item 0.85 ["reference content label: 4. Rubin B. 2005. Management of osteoarthritic knee pain. J "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
97 5 18 reference_content 5. Zizic T, Hoffman K, Holt P, et al. 1995. The treatment of osteoarthritis of the knee with pulsed electrical stimulation. J Rheumatol 22:1757–1761. [600.0, 1349.0, 1077.0, 1407.0] reference_item 0.85 ["reference content label: 5. Zizic T, Hoffman K, Holt P, et al. 1995. The treatment of"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
98 5 19 reference_content 6. Basset C, Pawluk R, Pilla A. 1974. Augmentation of bone repair by inductively coupled electromagnetic fields. Science 184:575–577. [600.0, 1410.0, 1077.0, 1466.0] reference_item 0.85 ["reference content label: 6. Basset C, Pawluk R, Pilla A. 1974. Augmentation of bone r"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
99 5 20 footer JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008 [67.0, 1498.0, 406.0, 1517.0] noise 0.9 ["footer label"] noise 0.9 tail_nonref_hold_zone unknown_like none False False
100 6 0 header PULSING ELECTRIC FIELD INCREASES CHONDROCYTE PROLIFERATION [445.0, 69.0, 1055.0, 88.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
101 6 1 number 859 [1083.0, 69.0, 1118.0, 87.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
102 6 2 reference_content 7. Fredericks D, Nepola J, Baker J, et al. 2000. Effect of pulsed electromagnetic fields on bone healing in a rabbit tibial osteotomy model. J Orthop Trauma 14:93–100. [123.0, 122.0, 599.0, 180.0] reference_item 0.85 ["reference content label: 7. Fredericks D, Nepola J, Baker J, et al. 2000. Effect of p"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
103 6 3 reference_content 8. Akai M, Hayashi K. 2002. Effect of electrical stimulation on musculoskeletal systems: a meta-analysis of controlled clinical trials. Bioelectromagnetics 23:132–143. [123.0, 182.0, 598.0, 239.0] reference_item 0.85 ["reference content label: 8. Akai M, Hayashi K. 2002. Effect of electrical stimulation"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
104 6 4 reference_content 9. Diniz P, Soejima K, Ito G. 2002. Nitric oxide mediates the effects of pulsed electromagnetic field stimulation on the osteoblast proliferation and differentiation. Nitric Oxide 7:18–23. [121.0, 242.0, 599.0, 299.0] reference_item 0.85 ["reference content label: 9. Diniz P, Soejima K, Ito G. 2002. Nitric oxide mediates th"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
105 6 5 reference_content 10. Cheng J, Zhang C, Han JS, et al. 2007. TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues. Med Sci Monit 13:163–167. [115.0, 301.0, 599.0, 358.0] reference_item 0.85 ["reference content label: 10. Cheng J, Zhang C, Han JS, et al. 2007. TENS stimulates c"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
106 6 6 reference_content 11. Van Susante JL, Buma P, Van Beuningen HM, et al. 2000. Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentrations. J Orthop Res 18:68–77. [115.0, 361.0, 598.0, 438.0] reference_item 0.85 ["reference content label: 11. Van Susante JL, Buma P, Van Beuningen HM, et al. 2000. R"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
107 6 7 reference_content 12. Guevara I, Iwanejko J, Dembinska-Kiec A, et al. 1998. Determination of nitrite/nitrate in human biological material by the simple Griess reaction. Clin Chim Acta 274:177–188. [115.0, 442.0, 598.0, 517.0] reference_item 0.85 ["reference content label: 12. Guevara I, Iwanejko J, Dembinska-Kiec A, et al. 1998. De"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
108 6 8 reference_content 13. Kronberg J, Ganey T, Fitzsimmons R. 2006. A novel niobium salt bridge for in vitro PEMF studies. 28th annual meeting, Bioelectromagnetics Society, abstract 11–5. [114.0, 521.0, 598.0, 578.0] reference_item 0.85 ["reference content label: 13. Kronberg J, Ganey T, Fitzsimmons R. 2006. A novel niobiu"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
109 6 9 reference_content 14. Ganey T. Personal communication, May 2006. [116.0, 579.0, 491.0, 598.0] reference_item 0.85 ["reference content label: 14. Ganey T. Personal communication, May 2006."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
110 6 10 reference_content 15. Knowles R, Palacios M, Palmer R, et al. 1989 Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Pro [116.0, 601.0, 599.0, 678.0] reference_item 0.85 ["reference content label: 15. Knowles R, Palacios M, Palmer R, et al. 1989 Formation o"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
111 6 11 reference_content 16. Brooks P. 2003. Inflammation as an important feature of osteoarthritis. Bull World Health Organ 81:689–690. [115.0, 680.0, 599.0, 718.0] reference_item 0.85 ["reference content label: 16. Brooks P. 2003. Inflammation as an important feature of "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
112 6 12 reference_content 17. Pilla A. 2006. Mechanisms and therapeutic applications of time varying and static magnetic fields. In: Barnes F, Greenebaum B, editors. Biological and medical aspects of electromagnetic fields. Bo [115.0, 721.0, 599.0, 798.0] reference_item 0.85 ["reference content label: 17. Pilla A. 2006. Mechanisms and therapeutic applications o"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
113 6 13 reference_content 18. DeMattei M, Caruso A, Pezzetti F, et al. 2001. Effects of pulsed electromagnetic fields on human articular chondrocyte proliferation. Connect Tissue Res 42:1–11. [634.0, 122.0, 1119.0, 180.0] reference_item 0.85 ["reference content label: 18. DeMattei M, Caruso A, Pezzetti F, et al. 2001. Effects o"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
114 6 14 reference_content 19. Fioravanti A, Nerucci F, Collodel G, et al. 2002. Biochemical and morphological study of human articular chondrocytes cultivated in the presence of pulsed signal therapy. Ann Rheum Dis 61:1032–103 [635.0, 182.0, 1118.0, 259.0] reference_item 0.85 ["reference content label: 19. Fioravanti A, Nerucci F, Collodel G, et al. 2002. Bioche"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
115 6 15 reference_content 20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression of neuronal nitric oxide synthase and phospholipase C- $ \gamma $1 in regenerating murine neuronal cells by pulsed electromagnetic field. Exp [633.0, 262.0, 1118.0, 338.0] reference_item 0.85 ["reference content label: 20. Kim S, Shin H, Eom D, et al. 2002. Enhanced expression o"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
116 6 16 reference_content 21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric oxide and wound repair: role of cytokines. Nitric Oxide 7:1–10. [632.0, 341.0, 1117.0, 379.0] reference_item 0.85 ["reference content label: 21. Schwentker A, Vodovotz Y, Weller R, et al. 2002. Nitric "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
117 6 17 reference_content 22. Miura M, Takayama K, Okada J. 1993. Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation. J Physiol 461:513–524. [633.0, 381.0, 1118.0, 439.0] reference_item 0.85 ["reference content label: 22. Miura M, Takayama K, Okada J. 1993. Increase in nitric o"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
118 6 18 reference_content 23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J B [633.0, 442.0, 1119.0, 537.0] reference_item 0.85 ["reference content label: 23. Knudsen G, Nishida C, Mooney S, et al. 2003. Nitric oxid"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
119 6 19 reference_content 24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/ligand binding kinetics: prediction of bioeffective waveform parameters. Bioelectrochem Bioenerg 48:27–34. [633.0, 541.0, 1118.0, 598.0] reference_item 0.85 ["reference content label: 24. Pilla A, Muehsam D, Markov M. 1999. EMF signals and ion/"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
120 6 20 reference_content 25. Markov MS, Pilla AA. 1997. Weak static magnetic field modulation of myosin phosphorylation in a cell-free preparation: calcium dependence. Bioelectrochem Bioenergetics 43:235–240. [633.0, 601.0, 1118.0, 676.0] reference_item 0.85 ["reference content label: 25. Markov MS, Pilla AA. 1997. Weak static magnetic field mo"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
121 6 21 reference_content 26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transduction in electrically stimulated bone cells. J Bone Joint Surg 83-A:1514–1523. [633.0, 681.0, 1118.0, 737.0] reference_item 0.85 ["reference content label: 26. Brighton C, Wang W, Seldes R, et al. 2001. Signal transd"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
122 6 22 reference_content 27. Ciombor DM, Lester G, Aaron RK, et al. 2002. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. J Orthop Res 20:40–50. [632.0, 741.0, 1120.0, 798.0] reference_item 0.85 ["reference content label: 27. Ciombor DM, Lester G, Aaron RK, et al. 2002. Low frequen"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
123 6 23 footer JOURNAL OF ORTHOPAEDIC RESEARCH JUNE 2008 [781.0, 1497.0, 1118.0, 1515.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False

76
audit/2AGGSMVQ/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,76 @@
{
"figures": {
"matched_count": 4,
"ambiguous_count": 2,
"unresolved_cluster_count": 0,
"unmatched_asset_count": 2,
"matched": [
{
"figure_number": 1,
"legend_block_id": 3,
"asset_block_ids": [
2
],
"page": 3,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 14,
"asset_block_ids": [
13
],
"page": 3,
"match_type": null
},
{
"figure_number": 4,
"legend_block_id": 3,
"asset_block_ids": [
2
],
"page": 4,
"match_type": null
},
{
"figure_number": 6,
"legend_block_id": 15,
"asset_block_ids": [
14
],
"page": 4,
"match_type": null
}
],
"ambiguous": [
{
"figure_number": 2,
"legend_block_id": 11,
"asset_block_ids": [],
"candidate_asset_ids": [
10,
13
],
"page": 3
},
{
"figure_number": 5,
"legend_block_id": 10,
"asset_block_ids": [],
"candidate_asset_ids": [
9,
14
],
"page": 4
}
],
"unresolved": []
},
"tables": {
"matched_count": 0,
"ambiguous_count": 0,
"unmatched_asset_count": 0,
"matched": [],
"ambiguous": []
}
}

1037
audit/2AGGSMVQ/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

147
audit/2AGGSMVQ/page_risk_summary.json Normal file
View file

@ -0,0 +1,147 @@
{
"pages": [
{
"page": 1,
"risk_score": 5,
"risk_reasons": [
"frontmatter_page"
],
"recommended_audit_targets": [
"frontmatter"
],
"counts": {
"body_paragraph": 8,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 4,
"risk_reasons": [
"hold_threshold",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"reading_order"
],
"counts": {
"body_paragraph": 10,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 3,
"unknown_structural": 3,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 3,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 3,
"table_like": 0,
"captions": 3,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 1
}
},
{
"page": 4,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 3,
"table_like": 0,
"captions": 3,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 1
}
},
{
"page": 5,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 10,
"reference_item": 6,
"tail_like": 3,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 21,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
2,
3,
4,
5
]
}

221
audit/2AGGSMVQ/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,221 @@
{
"candidates": [
{
"block_id": "p5:13",
"page": 5,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:14",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:15",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:16",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:17",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:18",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:19",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:20",
"page": 5,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:0",
"page": 6,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:1",
"page": 6,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:2",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:3",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:4",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:5",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:6",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:7",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:8",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:9",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:10",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:11",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:12",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:13",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:14",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:15",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:16",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:17",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:18",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:19",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:20",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:21",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:22",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

302
audit/2AGGSMVQ/reference_span_audit.json Normal file
View file

@ -0,0 +1,302 @@
{
"reference_span": {
"status": "ACCEPT",
"span_id": "refspan_001",
"start": {
"page": 5,
"column": 2,
"y": 1124.0,
"block_id": "p5:13"
},
"end": {
"page": 6,
"column": 2,
"y": 741.0,
"block_id": "p6:22"
},
"heading_block_id": "p5:13",
"ordered_block_ids": [
"p5:13",
"p5:14",
"p5:15",
"p5:16",
"p5:17",
"p5:18",
"p5:19",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p6:12",
"p6:13",
"p6:14",
"p6:15",
"p6:16",
"p6:17",
"p6:18",
"p6:19",
"p6:20",
"p6:21",
"p6:22"
],
"inside_block_ids": [
"p5:13",
"p5:14",
"p5:15",
"p5:16",
"p5:17",
"p5:18",
"p5:19",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p6:12",
"p6:13",
"p6:14",
"p6:15",
"p6:16",
"p6:17",
"p6:18",
"p6:19",
"p6:20",
"p6:21",
"p6:22"
],
"explicitly_outside_nearby_block_ids": [
"p5:12",
"p6:23"
],
"intrusion_candidates": [
{
"block_id": "p5:13",
"page": 5,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:14",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:15",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:16",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:17",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:18",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:19",
"page": 5,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p5:20",
"page": 5,
"role": "noise",
"zone": "tail_nonref_hold_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:0",
"page": 6,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:1",
"page": 6,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:2",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:3",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:4",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:5",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:6",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:7",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:8",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:9",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:10",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:11",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:12",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:13",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:14",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:15",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:16",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:17",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:18",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:19",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:20",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:21",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p6:22",
"page": 6,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}
}

535
audit/2BYRLKQS/audit_report.json Normal file
View file

@ -0,0 +1,535 @@
{
"paper_key": "2BYRLKQS",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:7268867c484bc2b5d4e9fad99d31fd113573a27115291eceb1e89ed882ef2261",
"meta_json_hash": "sha256:b81aaa1673fe3f8d9f2af5cb3dfdc29345442bde9bba2831c50ca83d3e8442f9",
"blocks_raw_hash": "sha256:db3bf01e4a7394b30182910c3a121bb424c79d30673c4f88a0331cbe500bf168",
"structured_blocks_hash": "sha256:367dffc78b9559100fe4bc68a201ddb4e837fc9841c4467e5133970c6b0d01bd",
"document_structure_hash": "sha256:8e425d134c676480c2747f69946fcbc2d6e79e8deb14b40037ae6089eba224d7",
"figure_inventory_hash": "sha256:9b425597f600f879137ff3d2d6b333f8c751995d041f5280a1993e0f0719512c",
"table_inventory_hash": "sha256:f6e23605db0b36875fd202e5db57e48cfad568a889a17264f80a0155d0aa9cee",
"reader_figures_hash": "sha256:e7cc09dbbc3829ff6d7b5264917d1699ebf5027e587c5c57b13075a238eb7e7e",
"resolved_metadata_hash": "sha256:637af4c6df06312ea992a460c1e67212122429d581f63bc4ea59d0679df33a58",
"fulltext_hash": "sha256:341b7c796700a6f3769f32f008eec59d428daa31763bdc0fa91fafcfa4d53054",
"block_trace_hash": "sha256:62fdae68f7e8a3b988847871a5ae245e41e43799e1ec0580019008d815efc58a",
"annotated_pages": {
"page_001.png": "sha256:5d51dcd307ab0df9f06f0008b8822ef7332186b494babce2b2b71bf919ce888d",
"page_002.png": "sha256:cbe887fea4d04f55b30805343b6d5d5c1dbf3d0b23a6cc9e1e3c1693cc8de078",
"page_003.png": "sha256:2d0025a22e92e60d0ad723698a99dfc37db88af5ae44bdd86ea8b54602061e20",
"page_004.png": "sha256:42d2376784f6f3b782f17a4e32719af2c62ba9899ee1a1bfd8d3c35363cacc50",
"page_005.png": "sha256:49a2d983cf4e154436bfde19c41e3505dd88f4469b15d092d2b540819d6cbd39",
"page_006.png": "sha256:991af5cdda885f2f5a3cf66d0103289f032e0c014b6b65c23bc404cf64ad5b7c",
"page_007.png": "sha256:b81c78d5fd91f2e28e00a1e0b5ff72a8c718f9079e70ccd488640adf0182c1b3",
"page_008.png": "sha256:ba498baa912f824e2178bb4fba4cbfacc05f173307b782492522d907d604d2bf",
"page_009.png": "sha256:0b1ef976ff84c108e7a65a10d3e3176136cd44c9d28b22e33403084708897cf2"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png",
"page_008.png",
"page_009.png"
]
},
"reviewed_pages": [
1,
4,
5,
6,
8,
9
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p1:19",
"p1:20",
"p1:21",
"p4:0",
"p4:1",
"p4:2",
"p4:3",
"p4:4",
"p4:5",
"p4:6",
"p4:7",
"p4:8",
"p4:9",
"p5:0",
"p5:1",
"p5:2",
"p5:3",
"p5:4",
"p5:5",
"p6:0",
"p6:1",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p8:0",
"p8:1",
"p8:2",
"p8:3",
"p8:4",
"p8:5",
"p8:6",
"p8:7",
"p8:8",
"p8:9",
"p8:10",
"p8:11",
"p8:12",
"p8:13",
"p8:14",
"p8:15",
"p8:16",
"p8:17",
"p8:18",
"p8:19",
"p8:20",
"p8:21",
"p8:22",
"p8:23",
"p8:24",
"p8:25",
"p8:26",
"p8:27",
"p8:28",
"p8:29",
"p8:30",
"p8:31",
"p8:32",
"p8:33",
"p8:34",
"p8:35",
"p8:36",
"p8:37",
"p8:38",
"p8:39",
"p8:40",
"p8:41",
"p8:42",
"p8:43",
"p9:0",
"p9:1",
"p9:2",
"p9:3",
"p9:4",
"p9:5",
"p9:6",
"p9:7",
"p9:8",
"p9:9",
"p9:10",
"p9:11",
"p9:12",
"p9:13",
"p9:14",
"p9:15",
"p9:16",
"p9:17",
"p9:18",
"p9:19",
"p9:20",
"p9:21",
"p9:22",
"p9:23",
"p9:24",
"p9:25",
"p9:26",
"p9:27",
"p9:28",
"p9:29",
"p9:30"
],
"findings": [
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:15"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:16"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:17"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:18"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:19"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:20"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:21"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:22"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:23"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:24"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:25"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:26"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:27"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:28"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:29"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p8:30"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p9:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_009.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p9:1"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_009.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p9:2"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_009.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p9:3"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_009.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "frontmatter_error",
"severity": "major",
"block_ids": [],
"truth": "page 1 should have clearer frontmatter role resolution",
"pipeline_behavior": "frontmatter page retains elevated unknown_structural density",
"root_cause_hypothesis": "frontmatter anchor or noise routing weakness",
"evidence": {
"annotated_page": "annotated_pages/page_001.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_009.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:0",
"p1:2",
"p1:5",
"p1:21",
"p2:0",
"p2:1",
"p2:2",
"p2:3",
"p3:0",
"p3:1",
"p3:2",
"p4:0",
"p4:1",
"p4:2",
"p5:0",
"p5:1",
"p6:0",
"p6:1",
"p6:2",
"p6:3"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

39
audit/2BYRLKQS/audit_report.md Normal file
View file

@ -0,0 +1,39 @@
# OCR Truth Audit Report - 2BYRLKQS
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 4, 5, 6, 8, 9]
- Reviewed blocks: 124
## Findings
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

1393
audit/2BYRLKQS/audit_scope.json Normal file
View file

File diff suppressed because it is too large Load diff

3328
audit/2BYRLKQS/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

182
audit/2BYRLKQS/block_trace.csv Normal file
View file

@ -0,0 +1,182 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,none,False,False
1,1,header_image,,"[732.0, 65.0, 1082.0, 135.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True
1,2,text,RESEARCH ARTICLE,"[116.0, 181.0, 393.0, 211.0]",authors,0.6,"[""page-1 initial-lastname author byline: RESEARCH ARTICLE""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True
1,3,text,Open Access,"[920.0, 184.0, 1073.0, 212.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Open Access""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False
1,4,doc_title,Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus),"[109.0, 242.0, 995.0, 396.0]",paper_title,0.8,"[""page-1 zone title_zone: Effects of microcurrent stimulation on Hyaline cartilage rep""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True
1,5,text,"Carla de Campos Ciccone¹, Denise Cristina Zuzzi¹, Lia Mara Grosso Neves¹, Josué Sampaio Mendonça¹, Paulo Pinto Joazeiro² and Marcelo Augusto Marretto Esquisatto¹*","[107.0, 411.0, 980.0, 470.0]",authors,0.8,"[""page-1 zone author_zone: Carla de Campos Ciccone\u00b9, Denise Cristina Zuzzi\u00b9, Lia Mara G""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True
1,6,paragraph_title,Abstract,"[122.0, 518.0, 208.0, 545.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True
1,7,abstract,"Background: In this study, we investigate the effects of microcurrent stimulation on the repair process of xiphoid cartilage in 45-days-old rats.","[118.0, 555.0, 1056.0, 606.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,8,abstract,"Methods: Twenty male rats were divided into a control group and a treated group. A 3-mm defect was then created with a punch in anesthetized animals. In the treated group, animals were submitted to da","[119.0, 610.0, 1065.0, 730.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,9,abstract,"Results: Basophilia increased gradually in control animals during the experimental period. In treated animals, newly formed cartilage was observed on days 21 and 35. No statistically significant diffe","[119.0, 735.0, 1067.0, 906.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,10,abstract,Conclusion: We conclude that microcurrent stimulation accelerates the cartilage repair in non-articular site from prepuberal animals.,"[120.0, 911.0, 1041.0, 960.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,11,text,"Keywords: Hyaline cartilage, Tissue repair, Extracellular matrix, Electrotherapy, Immature rats","[118.0, 968.0, 873.0, 995.0]",structured_insert,0.7,"[""keyword-like block: Keywords: Hyaline cartilage, Tissue repair, Extracellular ma""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,12,paragraph_title,Background,"[109.0, 1029.0, 228.0, 1052.0]",section_heading,0.5,"[""unnumbered paragraph_title on page 1 outside title zone: Background""]",section_heading,0.5,body_zone,heading_like,short_fragment,True,True
1,13,text,Most studies on cartilage repair use models of osteochondral defects since these defects are a major public health problem. Although these models permit to monitor the integration of articular cartila,"[106.0, 1054.0, 585.0, 1222.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,14,text,"Hyaline cartilage is a highly specialized, aneural and avascular connective tissue derived from the embryonic mesenchyme. Morphologically, this tissue is characterized by the presence of a small numbe","[107.0, 1223.0, 585.0, 1271.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,15,text,"mesenchyme. Morphologically, this tissue is character-
ized by the presence of a small number of cells, called
chondrocytes, which are responsible for the production,
organization and renewal of extra","[603.0, 1029.0, 1081.0, 1222.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,16,text,"The ECM is formed by a complex of macromolecules including collagens, proteoglycans (PGs) and non-collagen proteins. The interaction of these components ensures that an adequate amount of water is ret","[603.0, 1222.0, 1083.0, 1367.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,17,footnote,* Correspondence: marcelosquisatto@uniararas.br,"[109.0, 1314.0, 413.0, 1332.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: marcelosquisatto@uniararas.br""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False
1,18,footnote,"Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil","[108.0, 1332.0, 570.0, 1390.0]",footnote,0.7,"[""footnote label: Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biom\u00e9dicas, Centro Uni""]",footnote,0.7,body_zone,body_like,none,True,True
1,19,footnote,Full list of author information is available at the end of the article,"[108.0, 1386.0, 513.0, 1405.0]",footnote,0.7,"[""footnote label: Full list of author information is available at the end of t""]",footnote,0.7,body_zone,body_like,none,True,True
1,20,footer_image,,"[110.0, 1421.0, 336.0, 1467.0]",unknown_structural,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True
1,21,footer,© 2013 de Campos Ciccone et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/license,"[354.0, 1420.0, 1031.0, 1472.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
2,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
2,1,number,Page 2 of 9,"[997.0, 64.0, 1082.0, 88.0]",noise,0.9,"[""page number label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False
2,2,text,"Chondrocytes are nourished by the diffusion of nutrients through the ECM, either from synovial fluid or from capillaries in the perichondrium [5,6].","[106.0, 176.0, 585.0, 249.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,3,text,"The cartilaginous ECM consists of fibrillar elements such as collagen and elastin and PGs. The main types of collagen found in cartilage are, in decreasing order, types II, IX and XI. Collagen fibrils","[106.0, 247.0, 587.0, 946.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,4,text,Non-articular cartilage differs from articular cartilage by the fact that it is does not suffer the wear and tear of weight-bearing articular cartilage and that the defects induced are chondral and no,"[106.0, 944.0, 586.0, 1281.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,5,text,"There are various treatment options for articular cartilage defects. Electrical and electromagnetic stimulation and autologous grafts of chondrocytes, mesenchymal cells and biocompatible tissue derive","[106.0, 1280.0, 586.0, 1476.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,6,text,"Within this context, electrical stimulation as a thera-
peutic strategy for cartilage repair has been little investi-
gated [6,25,26] and knowledge about the response of
cartilage tissue of different ","[602.0, 176.0, 1084.0, 441.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,7,text,"Therefore, the objective of the present study was to investigate the structural and ultrastructural alterations that occur during the healing of non-articular cartilage defects after microcurrent stim","[602.0, 441.0, 1082.0, 561.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,8,paragraph_title,Methods Experimental groups,"[604.0, 582.0, 781.0, 632.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Methods Experimental groups""]",subsection_heading,0.6,frontmatter_side_zone,heading_like,none,True,True
2,9,footer,,"[604.0, 609.0, 781.0, 632.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False
2,10,text,"1wenty male Wistar rats, 45 days old and weighing 150 to 200 g, were obtained from the Center of Animal Experimentation, Centro Universitário Hermínio Ometto, UNIARARAS. The animals were housed in ind","[601.0, 631.0, 1083.0, 874.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: 1wenty male Wistar rats, 45 days old and weighing 150 to 200""]",frontmatter_noise,0.8,body_zone,body_like,none,False,False
2,11,paragraph_title,Experimental injury,"[604.0, 897.0, 772.0, 920.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Experimental injury""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True
2,12,text,"The animals were anesthetized with xylazine hydrochloride (0.2 mg/kg) and ketamine hydrochloride (1 mg/kg). After the ventral region was shaved at the height of the sternum, a 2-cm incision was made i","[602.0, 920.0, 1082.0, 1379.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,13,paragraph_title,Electrical current stimulation,"[604.0, 1401.0, 845.0, 1423.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrical current stimulation""]",subsection_heading,0.6,body_zone,body_like,none,True,True
2,14,text,Animals of the treated group received daily applications of a biphasic square pulse microgalvanic continuous,"[602.0, 1423.0, 1083.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
3,1,number,Page 3 of 9,"[997.0, 64.0, 1082.0, 88.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,2,text,"electrical current during 5 min (Physiotonus Microcurrent© stimulator - Bioset, Rio Claro, Sao Paulo, Brazil). In each application, it was used a frequency of 0.3 Hz and intensity of 20 μA. The pulse ","[106.0, 175.0, 586.0, 683.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,3,paragraph_title,Macroscopic inspection,"[107.0, 704.0, 307.0, 727.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Macroscopic inspection""]",subsection_heading,0.6,body_zone,body_like,none,True,True
3,4,text,"Xiphoid cartilage specimens fixed for histochemical analysis were used. The specimens were photographed with a PinePIX 300 digital camera in the front view. Anatomical features, including the appearan","[105.0, 727.0, 586.0, 875.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,5,paragraph_title,Histochemistry analysis,"[107.0, 897.0, 306.0, 919.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Histochemistry analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True
3,6,text,"After removal, the xiphoid cartilage fragments were fixed in 10% formaldehyde in Millonig buffer, pH 7.4, for 24 h at room temperature. The specimens were then transferred to buffer and processed rout","[106.0, 920.0, 586.0, 1330.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,7,paragraph_title,Electron microscopy and cytochemistry study,"[107.0, 1353.0, 484.0, 1376.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electron microscopy and cytochemistry study""]",subsection_heading,0.6,body_zone,body_like,none,True,True
3,8,text,"The cartilage samples of the two groups were fixed in 2% glutaraldehyde and 0.1% tannic acid dissolved in 0.1 M sodium cacodylate buffer, pH 7.3, for 2 h at room temperature. Next, the material was wa","[106.0, 1376.0, 587.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,9,text,"and postfixed in 1% osmium tetroxide for 1 h at 4°C.
After this step, the fragments were washed in glycated
saline, treated with 1% uranyl acetate for 18 at 4°C, again
washed in glycated saline, and d","[602.0, 175.0, 1084.0, 634.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,10,paragraph_title,Morphometric and statistical analysis,"[603.0, 656.0, 914.0, 680.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Morphometric and statistical analysis""]",subsection_heading,0.6,body_zone,body_like,none,True,True
3,11,text,"The cartilage repair area was determined on the digitized images as percent reduction of the original defect. Images of longitudinal sections stained with Toluidine blue, Dominici stain and picrosiriu","[602.0, 681.0, 1083.0, 1163.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,12,paragraph_title,Results,"[604.0, 1182.0, 681.0, 1206.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
3,13,text,Macroscopic inspection of the wound area showed the circular shape of the defect in control and treated animals and the absence of hemorrhagic or infectious processes at any of the time points studied,"[601.0, 1208.0, 1082.0, 1377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,14,text,"Toluidine blue staining (Figure 1) revealed a larger number of connective tissue cells in treated animals on day 7 when compared to the control group. In addition, a higher concentration of connective","[601.0, 1376.0, 1083.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 65.0, 675.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
4,1,number,Page 4 of 9,"[997.0, 65.0, 1082.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,2,figure_title,Table 1 Morphometric parameters evaluated in the defect area after different periods of time,"[107.0, 176.0, 531.0, 220.0]",table_caption,0.9,"[""table prefix matched: Table 1 Morphometric parameters evaluated in the defect area""]",table_caption,0.9,display_zone,table_caption_like,table_number,True,True
4,3,table,"<table><tr><td>Parameter</td><td>Time</td><td>Control group</td><td>Treated group</td></tr><tr><td></td><td>7d</td><td>$ 2.5 \pm 1.1 $</td><td>$ 2.9 \pm 1.8 $</td></tr><tr><td rowspan=""3"">Lesion r","[107.0, 217.0, 581.0, 751.0]",table_html,0.85,"[""media label: table""]",media_asset,0.85,body_zone,body_like,none,True,True
4,4,vision_footnote,"Measurements were obtained from samples collected on day 7 (7d), day 21 (21d), and day 35 (35d) after experimental injury. Three samples per animal were collected from the central region of the defect","[107.0, 755.0, 567.0, 861.0]",footnote,0.7,"[""vision_footnote label: Measurements were obtained from samples collected on day 7 (""]",footnote,0.7,body_zone,body_like,none,True,True
4,5,text,in central islands was observed in treated animals on day 21. New tissue formation accompanied by intense basophilia at the defect margins was seen in treated animals on day 21 and especially on day 3,"[602.0, 175.0, 1083.0, 513.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,6,text,Analysis of sections stained with picrosirius-hematoxylin and examined by bright-field microscopy under polarized light (Figure 2) showed a predominance of thick collagen fibers in the control group a,"[601.0, 513.0, 1083.0, 872.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,7,text,Electron photomicrographs of the repair tissue treated by the tannic acid method are shown in Figure 3. Fibroblast-like cells were observed in control animals on days 7 and 21. These cells were surrou,"[602.0, 872.0, 1083.0, 971.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,8,image,,"[252.0, 1007.0, 937.0, 1373.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,9,figure_title,Figure 1 Photomicrographs of longitudinal sections of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 µA/5 min). Spe,"[115.0, 1377.0, 1068.0, 1462.0]",figure_caption,0.92,"[""figure_title label: Figure 1 Photomicrographs of longitudinal sections of the xi""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
5,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 675.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
5,1,number,Page 5 of 9,"[997.0, 64.0, 1082.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,2,image,,"[253.0, 187.0, 936.0, 911.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,3,figure_title,Figure 2 Photomicrographs of sections stained with picrosirius-hematoxylin and analyzed by bright-field microscopy under polarized light (D-F and J-L). A-F: Control group; G-L: treated group. Specimen,"[116.0, 919.0, 1059.0, 984.0]",figure_caption,0.92,"[""figure_title label: Figure 2 Photomicrographs of sections stained with picrosiri""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
5,4,image,,"[251.0, 1039.0, 938.0, 1391.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,5,figure_title,Figure 3 Electron photomicrographs of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 μA/5 min). Specimens were coll,"[115.0, 1398.0, 1065.0, 1462.0]",figure_caption,0.92,"[""figure_title label: Figure 3 Electron photomicrographs of the xiphoid cartilage ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
6,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
6,1,number,Page 6 of 9,"[997.0, 65.0, 1081.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,2,text,"pericellular matrix that was looser than that seen in the region of the territorial matrix. In contrast, chondroblast-like cells characterized by cytoplasm rich in secretory vesicles and abundant roug","[107.0, 176.0, 586.0, 633.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,3,text,Figure 4 shows electron photomicrographs of the repair tissue submitted to cytochemical staining of PGs. Larger PG complexes were observed in treated animals on day 7 when compared to the control grou,"[106.0, 632.0, 586.0, 898.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 4 shows electron photomicrographs of the repair tissu""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True
6,4,paragraph_title,Discussion,"[108.0, 919.0, 216.0, 942.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
6,5,text,"Since non-articular cartilage defects and repair are uncommon in clinical practice, studies investigating these processes are important to gain insights into the reorganization of this tissue under di","[106.0, 944.0, 586.0, 995.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,6,text,"these processes are important to gain insights into the
reorganization of this tissue under different functional
conditions of the joints. In a recent study, Moyer et al.
[19] observed regeneration of","[602.0, 176.0, 1084.0, 560.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,7,text,"In the present study, only a small amount of newly formed cartilage was observed at the defect margins in all treated animals after 35 days of uninterrupted microcurrent application. These findings ag","[601.0, 561.0, 1083.0, 872.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,8,text,"Another relevant finding was the effect of microcurrent stimulation on the total number of fibroblast cells, which was higher in all treated animals when compared to the respective control group. In a","[601.0, 872.0, 1083.0, 995.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,9,image,,"[250.0, 1033.0, 946.0, 1390.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,10,figure_title,"Figure 4 Electron photomicrographs of sections from control (A-C) and treated (D-F) animals stained with cuprolinic blue for the detection of proteoglycans (PG). Specimens were collected 7 (A and D), ","[118.0, 1398.0, 1023.0, 1462.0]",figure_caption,0.92,"[""figure_title label: Figure 4 Electron photomicrographs of sections from control ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
7,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[107.0, 65.0, 676.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
7,1,number,Page 7 of 9,"[997.0, 65.0, 1081.0, 88.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
7,2,text,"organization of cartilage in treated animals may be the result of the beneficial effects of electrical stimulation on the production, maintenance and organization of ECM [6,31]. According to Aaron et ","[106.0, 176.0, 586.0, 369.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,3,text,"Another factor related to the effects of microcurrent stimulation is the induction of the proliferative and differentiation capacity of mesenchymal cells, which are found mainly in young animals [6,32","[106.0, 369.0, 587.0, 729.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,4,text,"The abundant presence of granulocytes in treated animals on days 7 and 21 is consistent with one of the most well-known effects of electrotherapy, particularly electrical current stimulation, i.e., th","[107.0, 729.0, 587.0, 1209.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,5,text,A larger number of birefringent fibers indicating a larger number of compacted collagen fibers were observed in control animals on day 35. The lack of an effect of electrical current stimulation on fi,"[106.0, 1208.0, 587.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,6,text,"of the healing process by increasing collagen fiber depos-
ition, cell proliferation, growth factor concentration, and
ATP levels. In addition to these observations, Kirsch and
Mercola [40] suggest th","[602.0, 176.0, 1083.0, 417.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,7,text,"Although the ideal parameters and type of electrical stimulation that is safe and efficient in promoting connective tissue repair, particularly cartilage repair $ [33,44] $, have not been established","[602.0, 416.0, 1083.0, 585.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,8,text,"In contrast to collagen fibers, the number of elastic fibers seems to be little influenced by microcurrent treatment. Traces of these fibers were observed in the two groups and at the different time p","[602.0, 585.0, 1082.0, 776.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,9,text,"Several studies on cartilage repair have shown that microcurrents tend to induce the formation of fibrocartilage in chondral defects, whereas osteochondral defects are filled with cartilage tissue sin","[601.0, 776.0, 1083.0, 1112.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,10,text,"The adequate combination of collagen fibrils and fibers and highly hydrated PGs permits cartilage to withstand the functional requirements during normal activity [4,47]. In the present study, no diffe","[602.0, 1112.0, 1084.0, 1475.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[108.0, 66.0, 675.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
8,1,number,Page 8 of 9,"[998.0, 66.0, 1081.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
8,2,text,"other hand, the number of stained PGs seems to indicate a positive effect of treatment on the deposition of these molecules in the tissue.","[107.0, 177.0, 584.0, 247.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,3,text,The predominance of chondroblast-like cells in the defect area of treated animals since the beginning of treatment highlights another important aspect of the effect of microcurrent stimulation on the ,"[107.0, 248.0, 585.0, 514.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,4,paragraph_title,Conclusion,"[109.0, 537.0, 217.0, 559.0]",section_heading,0.9,"[""explicit scholarly heading: Conclusion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
8,5,text,"We demonstrated that microcurrent stimulation has shown beneficial effects during non-articular cartilage repair in prepuberal animals. However, the period of observation was not sufficient to evaluat","[107.0, 562.0, 585.0, 729.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,6,paragraph_title,Competing interests,"[110.0, 747.0, 249.0, 764.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing interests""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True
8,7,text,The authors declare that they have no competing interest.,"[109.0, 764.0, 470.0, 783.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,8,paragraph_title,Authors' contributions,"[109.0, 801.0, 263.0, 819.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Authors' contributions""]",subsection_heading,0.6,body_zone,body_like,none,True,True
8,9,text,"CCC, DCZ and LMGN carried out experimental work, data collection and evaluation, literature search and manuscript preparation. JSM helped the surgical procedure and data collection. PPJ helped to prep","[107.0, 819.0, 583.0, 929.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,10,paragraph_title,Acknowledgements,"[110.0, 948.0, 245.0, 964.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements""]",sub_subsection_heading,0.6,body_zone,body_like,short_fragment,True,True
8,11,text,"The authors thank the technicians of the Laboratory of Micromorphology, Centro Universitário Hermínio Ometto, UNIARARAS, and of the Laboratory of Electron Microscopy, Instituto de Biologia, Universida","[108.0, 965.0, 579.0, 1039.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,12,paragraph_title,Author details,"[110.0, 1055.0, 209.0, 1073.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author details""]",subsection_heading,0.6,body_zone,body_like,short_fragment,True,True
8,13,text,"¹Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil. ²Departamento de Histologia e ","[109.0, 1073.0, 568.0, 1165.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,14,text,Received: 2 August 2012 Accepted: 16 January 2013 Published: 19 January 2013,"[109.0, 1182.0, 447.0, 1218.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,15,paragraph_title,References,"[111.0, 1236.0, 188.0, 1254.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,unknown_like,short_fragment,True,True
8,16,reference_content,"1. Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW: Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. Eur Cell Mater 2008, 16(1):26–33.","[111.0, 1256.0, 562.0, 1308.0]",reference_item,0.85,"[""reference content label: 1. Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW: C""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
8,17,reference_content,"2. Brighton CT, Wang W, Clark CC: Up-regulation of matrix in bovine articular cartilage explants by electric fields. Biochem Biophys Res Commun 2006, 342:556–561.","[110.0, 1310.0, 583.0, 1360.0]",reference_item,0.85,"[""reference content label: 2. Brighton CT, Wang W, Clark CC: Up-regulation of matrix in""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
8,18,reference_content,"3. Negri S, Farinato S, Fila C, Pagliaro P, Bellomi A: Tissue engineering: chondrocyte cultures on type I collagen support. Cytohistological and immunohistochemical study. J Orthopaed Traumatol 2007, ","[111.0, 1362.0, 571.0, 1415.0]",reference_item,0.85,"[""reference content label: 3. Negri S, Farinato S, Fila C, Pagliaro P, Bellomi A: Tissu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
8,19,reference_content,"4. Brighton CT, Wang W, Clark CC: The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants. J Bone Joint Surg Am 2000, 90:833–838.","[110.0, 1417.0, 579.0, 1470.0]",reference_item,0.85,"[""reference content label: 4. Brighton CT, Wang W, Clark CC: The effect of electrical f""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
8,20,reference_content,"5. Newman AP: Articular Cartilage Repair. Am J Sports Med 1998, 26:309–324.","[606.0, 181.0, 1076.0, 200.0]",reference_item,0.85,"[""reference content label: 5. Newman AP: Articular Cartilage Repair. Am J Sports Med 19""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,21,reference_content,"6. Akanji OO, Lee DA, Bader DA: The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs. Biorheology 2008, 45:229–243.","[606.0, 199.0, 1077.0, 251.0]",reference_item,0.85,"[""reference content label: 6. Akanji OO, Lee DA, Bader DA: The effects of direct curren""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,22,reference_content,"7. Vidal BC: Cell and extracellular matrix interaction: a feedback theory based on molecular order recognition-adhesion events. Rev Med Unicamp 1993, 4:1–6.","[605.0, 253.0, 1078.0, 306.0]",reference_item,0.85,"[""reference content label: 7. Vidal BC: Cell and extracellular matrix interaction: a fe""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,23,reference_content,"8. Hall AC, Horwitz ER, Wilkins RJ: The cellular physiology of articular cartilage. Exp Physiol 1996, 81:535–545.","[606.0, 307.0, 1032.0, 345.0]",reference_item,0.85,"[""reference content label: 8. Hall AC, Horwitz ER, Wilkins RJ: The cellular physiology ""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,24,reference_content,"9. Buckwalter JA, Mankin HJ: Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr Course Lect 1998, 47:477–486.","[608.0, 345.0, 1036.0, 381.0]",reference_item,0.85,"[""reference content label: 9. Buckwalter JA, Mankin HJ: Articular cartilage: tissue des""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,25,reference_content,"10. Hyttinen MM, Arokoskit JPA, Parkkinen JJ, Lammi MJ, Lapvetelainen T, Mauranent K, Király K, Tammi MJ, Helminen HJ: Age matters: collagen birefringence of superficial articular cartilage is increas","[608.0, 382.0, 1071.0, 470.0]",reference_item,0.85,"[""reference content label: 10. Hyttinen MM, Arokoskit JPA, Parkkinen JJ, Lammi MJ, Lapv""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,26,reference_content,"11. Carrington JL: Aging bone and cartilage: cross-cutting issues. Biochem Biophys Res Commun. 2005, 18:700–708.","[608.0, 472.0, 1054.0, 507.0]",reference_item,0.85,"[""reference content label: 11. Carrington JL: Aging bone and cartilage: cross-cutting i""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,27,reference_content,"12. Hennerbichler A, Rosenberger R, Arora R, Hennerbichler D: Biochemical, biomechanical and histological properties of osteoarthritic porcine knee cartilage: implications for osteochondral transplant","[608.0, 509.0, 1074.0, 579.0]",reference_item,0.85,"[""reference content label: 12. Hennerbichler A, Rosenberger R, Arora R, Hennerbichler D""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,28,reference_content,"13. Nixon AJ, Fortier LA: New Horizons in Articular Cartilage Repair. AAEP Proceedings 2001, 47:217–226.","[608.0, 581.0, 1050.0, 615.0]",reference_item,0.85,"[""reference content label: 13. Nixon AJ, Fortier LA: New Horizons in Articular Cartilag""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,29,reference_content,"14. Anraku Y, Mizuta H, Sei A, Kudo S, Nakamura E, Senba K, Hiraki Y: Analyses of early events during chondrogenic repair in rat full-thickness articular cartilages defects. J Bone Miner Metab 2009, 2","[608.0, 617.0, 1070.0, 670.0]",reference_item,0.85,"[""reference content label: 14. Anraku Y, Mizuta H, Sei A, Kudo S, Nakamura E, Senba K, ""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,30,reference_content,"15. Johnson TS, Xu JW, Zaporojan W, Mesa JM, Weinand C, Randolph MA, Bonassar LJ, Winograd JM, Yaremchuk MJ: Integrative repair of cartilage with articular and nonarticular chondrocytes. Tissue Eng 20","[608.0, 673.0, 1074.0, 724.0]",reference_item,0.85,"[""reference content label: 15. Johnson TS, Xu JW, Zaporojan W, Mesa JM, Weinand C, Rand""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,31,reference_content,"16. Beris AE, Lykissas MG, Papageorgiou CD, Georgoulis AD: Advances in articular cartilage repair. J Care Injured 2005, 365:S14–S23.","[609.0, 726.0, 1039.0, 761.0]",reference_item,0.85,"[""reference content label: 16. Beris AE, Lykissas MG, Papageorgiou CD, Georgoulis AD: A""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,32,reference_content,"17. Redman SN, Oldfield SF, Archer CW: Current strategies for articular cartilage repair. Eur Cells Mater 2005, 9:23–32.","[608.0, 763.0, 1033.0, 797.0]",reference_item,0.85,"[""reference content label: 17. Redman SN, Oldfield SF, Archer CW: Current strategies fo""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,33,reference_content,"18. Etawil NM, Bari C, Achan P, Pitzalis C, Dell'Accio F: A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after surface injury. Osteoarthr Cartilage 2009, 17:6","[608.0, 800.0, 1070.0, 852.0]",reference_item,0.85,"[""reference content label: 18. Etawil NM, Bari C, Achan P, Pitzalis C, Dell'Accio F: A ""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,34,reference_content,"19. Moyer HR, Wang Y, Farooque T, Wick T, Singh KA, Xie L, Guldberg RE, Williams JK, Boyan BD, Schwartz Z: A new animal model for assessing cartilage repair and regeneration at a nonarticular site. Ti","[607.0, 855.0, 1068.0, 924.0]",reference_item,0.85,"[""reference content label: 19. Moyer HR, Wang Y, Farooque T, Wick T, Singh KA, Xie L, G""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,35,reference_content,"20. Stockwell RA: Lipid content of human costal and articular cartilage. Ann Rheum Dis 1967, 26:481–486.","[607.0, 927.0, 1067.0, 960.0]",reference_item,0.85,"[""reference content label: 20. Stockwell RA: Lipid content of human costal and articula""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,36,reference_content,"21. Souza TD, Del Carlo RJ, Viloria MIV: Histologic evaluation of the repair process in the articular surface of rabbits. Ciência Rural 2000, 30:439–444.","[607.0, 963.0, 1070.0, 999.0]",reference_item,0.85,"[""reference content label: 21. Souza TD, Del Carlo RJ, Viloria MIV: Histologic evaluati""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,37,reference_content,"22. Nieduszynski IA, Huckerby TN, Dickenson JM, Brown GM, Tai GH, Morris HG, Eady S: There are two major types of skeletal keratin sulphates. Biochem J 1990, 271:243–249.","[607.0, 1000.0, 1079.0, 1051.0]",reference_item,0.85,"[""reference content label: 22. Nieduszynski IA, Huckerby TN, Dickenson JM, Brown GM, Ta""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,38,reference_content,"23. Brown CJ, Caswell AM, Rahman S, Russell RS, Buttle DJ: Proteoglycan breakdown from bovine nasal cartilage is increased, and from articular cartilage is decreased, by extracellular ATP. Biochim Bio","[607.0, 1054.0, 1066.0, 1125.0]",reference_item,0.85,"[""reference content label: 23. Brown CJ, Caswell AM, Rahman S, Russell RS, Buttle DJ: P""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,39,reference_content,"24. Khubutiva MS, Yu I, Kliukvin LP, Istranov VB, Khvatov AB, Shekhter A, Vaza IV, Kanakov VS: Stimulation of regeneration of hyaline cartilage in experimental osteochondral injury. Bull Exp Biol Med ","[607.0, 1127.0, 1075.0, 1180.0]",reference_item,0.85,"[""reference content label: 24. Khubutiva MS, Yu I, Kliukvin LP, Istranov VB, Khvatov AB""]",reference_item,0.85,,reference_like,reference_numeric_dot,True,True
8,40,reference_content,"27. Bobic V: Current status of the articular cartilage repair. Orthop Knee Surg 2000, 13:37–42.","[607.0, 1254.0, 1066.0, 1289.0]",reference_item,0.85,"[""reference content label: 27. Bobic V: Current status of the articular cartilage repai""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
8,41,reference_content,"28. Haddad JB, Obolensky AG, Shinnick P: The biology effects and the therapeutic mechanism of action of electric and electromagnetic field stimulation on bone cartilage: new findings and review of ear","[607.0, 1291.0, 1066.0, 1361.0]",reference_item,0.85,"[""reference content label: 28. Haddad JB, Obolensky AG, Shinnick P: The biology effects""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
8,42,reference_content,"29. Scott JE, Haigh M, Nusgens B, Lapière CM: Proteoglycan: collagen interactions in dermatosparactic skin and tendon. An electron histochemical study using cupromeronic blue in a critical electrolyte","[606.0, 1363.0, 1052.0, 1434.0]",reference_item,0.85,"[""reference content label: 29. Scott JE, Haigh M, Nusgens B, Lapi\u00e8re CM: Proteoglycan: ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
8,43,reference_content,"30. Baker B, Spadaro J, Marino A, Becker RO: Electrical stimulation of articular cartilage regeneration. Ann NY Acad Sci 1974, 238:491–499.","[607.0, 1436.0, 1067.0, 1470.0]",reference_item,0.85,"[""reference content label: 30. Baker B, Spadaro J, Marino A, Becker RO: Electrical stim""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,0,header,"de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17","[109.0, 66.0, 675.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
9,1,number,Page 9 of 9,"[997.0, 65.0, 1081.0, 87.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
9,2,reference_content,"31. Lai WM, Sun GA, Ateshian XE, Mow VC: Electrical signals for chondrocytes in cartilage. Biorheology 2002, 39(1):39–45.","[111.0, 181.0, 576.0, 216.0]",reference_item,0.85,"[""reference content label: 31. Lai WM, Sun GA, Ateshian XE, Mow VC: Electrical signals ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,3,reference_content,"32. Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ: Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop Rel Res 2004, 419(1):30–37.","[111.0, 217.0, 563.0, 269.0]",reference_item,0.85,"[""reference content label: 32. Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ: St""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,4,reference_content,"33. Nogami H, Aoki BE, Okagawa T, Mimatsu K: Effects of electric current on chondrogenesis in vitro. Basic science and pathology. Clin Orthop Rel Res 1982, 163:243–247.","[112.0, 271.0, 574.0, 322.0]",reference_item,0.85,"[""reference content label: 33. Nogami H, Aoki BE, Okagawa T, Mimatsu K: Effects of elec""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,5,reference_content,"34. Aaron RK, MacK D, Ciombor DM, Simon BJ: Treatment of nonunions with electric and electromagnetic fields. Clin Orthop 2004, 419(1):21–29.","[112.0, 325.0, 571.0, 360.0]",reference_item,0.85,"[""reference content label: 34. Aaron RK, MacK D, Ciombor DM, Simon BJ: Treatment of non""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,6,reference_content,"35. Westers BM: Review of the repair of defects in articular cartilage. JOSPT 1982, 4:6–15.","[112.0, 361.0, 568.0, 395.0]",reference_item,0.85,"[""reference content label: 35. Westers BM: Review of the repair of defects in articular""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,7,reference_content,"36. Oikhana H, Shimomura Y: Effect of direct current on cultured growth cartilage cells in vitro. J Orthop Res 1988, 6:690–694.","[112.0, 397.0, 553.0, 432.0]",reference_item,0.85,"[""reference content label: 36. Oikhana H, Shimomura Y: Effect of direct current on cult""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,8,reference_content,"37. Davis P: Microcurrent. A modern healthcare modality. Rehab Ther Prod Rev 1992, 10:62–66.","[112.0, 433.0, 581.0, 468.0]",reference_item,0.85,"[""reference content label: 37. Davis P: Microcurrent. A modern healthcare modality. Reh""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,9,reference_content,"38. Sonnewend D, Oliveira JLR, Nicolau RA, Zângaro RA, Pacheco MTT:","[112.0, 469.0, 531.0, 485.0]",reference_item,0.85,"[""reference content label: 38. Sonnewend D, Oliveira JLR, Nicolau RA, Z\u00e2ngaro RA, Pache""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,10,reference_content,Avaliação do efeito da microterapia celular (microcorrentes) sobre o processo inicial da cicatrização de feridas em ratos. In XI INIC Encontro Latino Americano de Iniciação Científica e V EPG Encontro,"[112.0, 481.0, 572.0, 575.0]",reference_item,0.85,"[""reference content label: Avalia\u00e7\u00e3o do efeito da microterapia celular (microcorrentes)""]",reference_item,0.85,reference_zone,reference_like,none,True,True
9,11,reference_content,"39. Lee BY, Wendell K, Al-Waili N, Butler G: Ultra-low microcurrent therapy: a novel approach for treatment of chronic resistant wounds. Adv Ther 2007, 24:1202–1209.","[112.0, 577.0, 582.0, 629.0]",reference_item,0.85,"[""reference content label: 39. Lee BY, Wendell K, Al-Waili N, Butler G: Ultra-low micro""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,12,reference_content,"40. Kirsch DL, Mercola JM: The basis for microcurrent electrical therapy in conventional medical practice. J Adv Med 1995, 8:83–97.","[112.0, 630.0, 561.0, 667.0]",reference_item,0.85,"[""reference content label: 40. Kirsch DL, Mercola JM: The basis for microcurrent electr""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,13,reference_content,"41. Cheng N, Hoof HV, Bock E, Hoogmartens MJ, Mulier JC, Ducker FJ, Sansen WM, Loecker W: The effect of electric current on ATP generation, protein synthesis, membrane transport in rat skin. Clin Orth","[111.0, 668.0, 577.0, 737.0]",reference_item,0.85,"[""reference content label: 41. Cheng N, Hoof HV, Bock E, Hoogmartens MJ, Mulier JC, Duc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,14,reference_content,42. Nordenstrom B: Biologically Closed Electrical Circuits. Uppsala: Nordic Medical Publications; 1983.,"[111.0, 738.0, 578.0, 774.0]",reference_item,0.85,"[""reference content label: 42. Nordenstrom B: Biologically Closed Electrical Circuits. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,15,reference_content,"43. Chao P-H, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT: Chondrocyte translocation response to direct current electric fields. J Biomech Eng 2000, 122:261–267.","[110.0, 776.0, 554.0, 827.0]",reference_item,0.85,"[""reference content label: 43. Chao P-H, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT: Ch""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,16,reference_content,"44. Dodge GR, Bowen JR, Wug OHC, Tokmakova K, Simon BJ, Aroojis A, Potter K: Electrical stimulation of the growth plate: a potential approach to an epiphysiodesis. Bioelectromagnetics 2007, 28:463–470","[111.0, 829.0, 572.0, 882.0]",reference_item,0.85,"[""reference content label: 44. Dodge GR, Bowen JR, Wug OHC, Tokmakova K, Simon BJ, Aroo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,17,reference_content,"45. Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct current-induced repair of articular cartilage in rabbit osteochondral defects. J Orthop Res 1990, 8:266–275.","[111.0, 883.0, 571.0, 935.0]",reference_item,0.85,"[""reference content label: 45. Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,18,reference_content,"46. Black J: Electrical Stimulation of Hard and Soft Tissue in Animal Models. Clin Plast Surg 1985, 12:243–257.","[111.0, 937.0, 572.0, 972.0]",reference_item,0.85,"[""reference content label: 46. Black J: Electrical Stimulation of Hard and Soft Tissue ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,19,reference_content,"47. Reichenberger E, Olsen BR: Collagens as organizers of extracellular matrix during morphogenesis. Semin Cell Dev Biol 1996, 7:631–638.","[112.0, 973.0, 577.0, 1008.0]",reference_item,0.85,"[""reference content label: 47. Reichenberger E, Olsen BR: Collagens as organizers of ex""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,20,reference_content,"48. Takei N, Akai M: Effect of direct current stimulation on triradiate physeal cartilage. In vivo study in young rabbits. Arch Orthop Trauma Surg 1993, 112:159–162.","[113.0, 1010.0, 574.0, 1061.0]",reference_item,0.85,"[""reference content label: 48. Takei N, Akai M: Effect of direct current stimulation on""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
9,21,text,"doi:10.1186/1472-6882-13-17
Cite this article as: de Campos Ciccone et al.: Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus). BMC Complementary","[118.0, 1084.0, 550.0, 1154.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
9,22,paragraph_title,Submit your next manuscript to BioMed Central and take full advantage of:,"[642.0, 1213.0, 1049.0, 1259.0]",structured_insert,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Submit your next manuscript to BioMed Central and take full ""]",subsection_heading,0.6,tail_nonref_hold_zone,unknown_like,none,False,False
9,23,text,• Convenient online submission,"[641.0, 1280.0, 850.0, 1299.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False
9,24,text,• Thorough peer review,"[640.0, 1305.0, 801.0, 1324.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False
9,25,text,• No space constraints or color figure charges,"[640.0, 1330.0, 938.0, 1350.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False
9,26,text,• Immediate publication on acceptance,"[641.0, 1356.0, 897.0, 1374.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False
9,27,text,"• Inclusion in PubMed, CAS, Scopus and Google Scholar","[641.0, 1380.0, 1001.0, 1399.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False
9,28,text,• Research which is freely available for redistribution,"[641.0, 1404.0, 987.0, 1424.0]",structured_insert,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,False,False
9,29,footer,Submit your manuscript at www.biomedcentral.com/submit,"[642.0, 1449.0, 839.0, 1480.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
9,30,footer_image,,"[904.0, 1448.0, 1050.0, 1478.0]",structured_insert,0.2,"[""unrecognized label 'footer_image'""]",unknown_structural,0.2,,unknown_like,empty,False,False
1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [107.0, 65.0, 676.0, 108.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like none False False
3 1 1 header_image [732.0, 65.0, 1082.0, 135.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False True
4 1 2 text RESEARCH ARTICLE [116.0, 181.0, 393.0, 211.0] authors 0.6 ["page-1 initial-lastname author byline: RESEARCH ARTICLE"] authors 0.6 frontmatter_main_zone support_like short_fragment True True
5 1 3 text Open Access [920.0, 184.0, 1073.0, 212.0] frontmatter_noise 0.7 ["frontmatter noise text: Open Access"] frontmatter_noise 0.7 frontmatter_main_zone support_like short_fragment False False
6 1 4 doc_title Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus) [109.0, 242.0, 995.0, 396.0] paper_title 0.8 ["page-1 zone title_zone: Effects of microcurrent stimulation on Hyaline cartilage rep"] paper_title 0.8 frontmatter_main_zone support_like none True True
7 1 5 text Carla de Campos Ciccone¹, Denise Cristina Zuzzi¹, Lia Mara Grosso Neves¹, Josué Sampaio Mendonça¹, Paulo Pinto Joazeiro² and Marcelo Augusto Marretto Esquisatto¹* [107.0, 411.0, 980.0, 470.0] authors 0.8 ["page-1 zone author_zone: Carla de Campos Ciccone\u00b9, Denise Cristina Zuzzi\u00b9, Lia Mara G"] authors 0.8 frontmatter_main_zone support_like none True True
8 1 6 paragraph_title Abstract [122.0, 518.0, 208.0, 545.0] abstract_heading 0.95 ["abstract heading"] abstract_heading 0.95 frontmatter_main_zone heading_like short_fragment True True
9 1 7 abstract Background: In this study, we investigate the effects of microcurrent stimulation on the repair process of xiphoid cartilage in 45-days-old rats. [118.0, 555.0, 1056.0, 606.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
10 1 8 abstract Methods: Twenty male rats were divided into a control group and a treated group. A 3-mm defect was then created with a punch in anesthetized animals. In the treated group, animals were submitted to da [119.0, 610.0, 1065.0, 730.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
11 1 9 abstract Results: Basophilia increased gradually in control animals during the experimental period. In treated animals, newly formed cartilage was observed on days 21 and 35. No statistically significant diffe [119.0, 735.0, 1067.0, 906.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
12 1 10 abstract Conclusion: We conclude that microcurrent stimulation accelerates the cartilage repair in non-articular site from prepuberal animals. [120.0, 911.0, 1041.0, 960.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
13 1 11 text Keywords: Hyaline cartilage, Tissue repair, Extracellular matrix, Electrotherapy, Immature rats [118.0, 968.0, 873.0, 995.0] structured_insert 0.7 ["keyword-like block: Keywords: Hyaline cartilage, Tissue repair, Extracellular ma"] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
14 1 12 paragraph_title Background [109.0, 1029.0, 228.0, 1052.0] section_heading 0.5 ["unnumbered paragraph_title on page 1 outside title zone: Background"] section_heading 0.5 body_zone heading_like short_fragment True True
15 1 13 text Most studies on cartilage repair use models of osteochondral defects since these defects are a major public health problem. Although these models permit to monitor the integration of articular cartila [106.0, 1054.0, 585.0, 1222.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
16 1 14 text Hyaline cartilage is a highly specialized, aneural and avascular connective tissue derived from the embryonic mesenchyme. Morphologically, this tissue is characterized by the presence of a small numbe [107.0, 1223.0, 585.0, 1271.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
17 1 15 text mesenchyme. Morphologically, this tissue is character- ized by the presence of a small number of cells, called chondrocytes, which are responsible for the production, organization and renewal of extra [603.0, 1029.0, 1081.0, 1222.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
18 1 16 text The ECM is formed by a complex of macromolecules including collagens, proteoglycans (PGs) and non-collagen proteins. The interaction of these components ensures that an adequate amount of water is ret [603.0, 1222.0, 1083.0, 1367.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
19 1 17 footnote * Correspondence: marcelosquisatto@uniararas.br [109.0, 1314.0, 413.0, 1332.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: * Correspondence: marcelosquisatto@uniararas.br"] frontmatter_noise 0.8 body_zone body_like none False False
20 1 18 footnote Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil [108.0, 1332.0, 570.0, 1390.0] footnote 0.7 ["footnote label: Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Biom\u00e9dicas, Centro Uni"] footnote 0.7 body_zone body_like none True True
21 1 19 footnote Full list of author information is available at the end of the article [108.0, 1386.0, 513.0, 1405.0] footnote 0.7 ["footnote label: Full list of author information is available at the end of t"] footnote 0.7 body_zone body_like none True True
22 1 20 footer_image [110.0, 1421.0, 336.0, 1467.0] unknown_structural 0.2 ["unrecognized label 'footer_image'"] unknown_structural 0.2 body_zone unknown_like empty False True
23 1 21 footer © 2013 de Campos Ciccone et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/license [354.0, 1420.0, 1031.0, 1472.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
24 2 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [108.0, 65.0, 676.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
25 2 1 number Page 2 of 9 [997.0, 64.0, 1082.0, 88.0] noise 0.9 ["page number label"] noise 0.9 frontmatter_side_zone support_like short_fragment False False
26 2 2 text Chondrocytes are nourished by the diffusion of nutrients through the ECM, either from synovial fluid or from capillaries in the perichondrium [5,6]. [106.0, 176.0, 585.0, 249.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
27 2 3 text The cartilaginous ECM consists of fibrillar elements such as collagen and elastin and PGs. The main types of collagen found in cartilage are, in decreasing order, types II, IX and XI. Collagen fibrils [106.0, 247.0, 587.0, 946.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
28 2 4 text Non-articular cartilage differs from articular cartilage by the fact that it is does not suffer the wear and tear of weight-bearing articular cartilage and that the defects induced are chondral and no [106.0, 944.0, 586.0, 1281.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
29 2 5 text There are various treatment options for articular cartilage defects. Electrical and electromagnetic stimulation and autologous grafts of chondrocytes, mesenchymal cells and biocompatible tissue derive [106.0, 1280.0, 586.0, 1476.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
30 2 6 text Within this context, electrical stimulation as a thera- peutic strategy for cartilage repair has been little investi- gated [6,25,26] and knowledge about the response of cartilage tissue of different [602.0, 176.0, 1084.0, 441.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
31 2 7 text Therefore, the objective of the present study was to investigate the structural and ultrastructural alterations that occur during the healing of non-articular cartilage defects after microcurrent stim [602.0, 441.0, 1082.0, 561.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
32 2 8 paragraph_title Methods Experimental groups [604.0, 582.0, 781.0, 632.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Methods Experimental groups"] subsection_heading 0.6 frontmatter_side_zone heading_like none True True
33 2 9 footer [604.0, 609.0, 781.0, 632.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like empty False False
34 2 10 text 1wenty male Wistar rats, 45 days old and weighing 150 to 200 g, were obtained from the Center of Animal Experimentation, Centro Universitário Hermínio Ometto, UNIARARAS. The animals were housed in ind [601.0, 631.0, 1083.0, 874.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: 1wenty male Wistar rats, 45 days old and weighing 150 to 200"] frontmatter_noise 0.8 body_zone body_like none False False
35 2 11 paragraph_title Experimental injury [604.0, 897.0, 772.0, 920.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Experimental injury"] subsection_heading 0.6 body_zone body_like short_fragment True True
36 2 12 text The animals were anesthetized with xylazine hydrochloride (0.2 mg/kg) and ketamine hydrochloride (1 mg/kg). After the ventral region was shaved at the height of the sternum, a 2-cm incision was made i [602.0, 920.0, 1082.0, 1379.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
37 2 13 paragraph_title Electrical current stimulation [604.0, 1401.0, 845.0, 1423.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Electrical current stimulation"] subsection_heading 0.6 body_zone body_like none True True
38 2 14 text Animals of the treated group received daily applications of a biphasic square pulse microgalvanic continuous [602.0, 1423.0, 1083.0, 1475.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
39 3 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [107.0, 65.0, 676.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
40 3 1 number Page 3 of 9 [997.0, 64.0, 1082.0, 88.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
41 3 2 text electrical current during 5 min (Physiotonus Microcurrent© stimulator - Bioset, Rio Claro, Sao Paulo, Brazil). In each application, it was used a frequency of 0.3 Hz and intensity of 20 μA. The pulse [106.0, 175.0, 586.0, 683.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
42 3 3 paragraph_title Macroscopic inspection [107.0, 704.0, 307.0, 727.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Macroscopic inspection"] subsection_heading 0.6 body_zone body_like none True True
43 3 4 text Xiphoid cartilage specimens fixed for histochemical analysis were used. The specimens were photographed with a PinePIX 300 digital camera in the front view. Anatomical features, including the appearan [105.0, 727.0, 586.0, 875.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
44 3 5 paragraph_title Histochemistry analysis [107.0, 897.0, 306.0, 919.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Histochemistry analysis"] subsection_heading 0.6 body_zone body_like none True True
45 3 6 text After removal, the xiphoid cartilage fragments were fixed in 10% formaldehyde in Millonig buffer, pH 7.4, for 24 h at room temperature. The specimens were then transferred to buffer and processed rout [106.0, 920.0, 586.0, 1330.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
46 3 7 paragraph_title Electron microscopy and cytochemistry study [107.0, 1353.0, 484.0, 1376.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Electron microscopy and cytochemistry study"] subsection_heading 0.6 body_zone body_like none True True
47 3 8 text The cartilage samples of the two groups were fixed in 2% glutaraldehyde and 0.1% tannic acid dissolved in 0.1 M sodium cacodylate buffer, pH 7.3, for 2 h at room temperature. Next, the material was wa [106.0, 1376.0, 587.0, 1475.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
48 3 9 text and postfixed in 1% osmium tetroxide for 1 h at 4°C. After this step, the fragments were washed in glycated saline, treated with 1% uranyl acetate for 18 at 4°C, again washed in glycated saline, and d [602.0, 175.0, 1084.0, 634.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
49 3 10 paragraph_title Morphometric and statistical analysis [603.0, 656.0, 914.0, 680.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Morphometric and statistical analysis"] subsection_heading 0.6 body_zone body_like none True True
50 3 11 text The cartilage repair area was determined on the digitized images as percent reduction of the original defect. Images of longitudinal sections stained with Toluidine blue, Dominici stain and picrosiriu [602.0, 681.0, 1083.0, 1163.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
51 3 12 paragraph_title Results [604.0, 1182.0, 681.0, 1206.0] section_heading 0.9 ["explicit scholarly heading: Results"] section_heading 0.9 body_zone heading_like canonical_section_name True True
52 3 13 text Macroscopic inspection of the wound area showed the circular shape of the defect in control and treated animals and the absence of hemorrhagic or infectious processes at any of the time points studied [601.0, 1208.0, 1082.0, 1377.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
53 3 14 text Toluidine blue staining (Figure 1) revealed a larger number of connective tissue cells in treated animals on day 7 when compared to the control group. In addition, a higher concentration of connective [601.0, 1376.0, 1083.0, 1475.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
54 4 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [108.0, 65.0, 675.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
55 4 1 number Page 4 of 9 [997.0, 65.0, 1082.0, 87.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
56 4 2 figure_title Table 1 Morphometric parameters evaluated in the defect area after different periods of time [107.0, 176.0, 531.0, 220.0] table_caption 0.9 ["table prefix matched: Table 1 Morphometric parameters evaluated in the defect area"] table_caption 0.9 display_zone table_caption_like table_number True True
57 4 3 table <table><tr><td>Parameter</td><td>Time</td><td>Control group</td><td>Treated group</td></tr><tr><td></td><td>7d</td><td>$ 2.5 \pm 1.1 $</td><td>$ 2.9 \pm 1.8 $</td></tr><tr><td rowspan="3">Lesion r [107.0, 217.0, 581.0, 751.0] table_html 0.85 ["media label: table"] media_asset 0.85 body_zone body_like none True True
58 4 4 vision_footnote Measurements were obtained from samples collected on day 7 (7d), day 21 (21d), and day 35 (35d) after experimental injury. Three samples per animal were collected from the central region of the defect [107.0, 755.0, 567.0, 861.0] footnote 0.7 ["vision_footnote label: Measurements were obtained from samples collected on day 7 ("] footnote 0.7 body_zone body_like none True True
59 4 5 text in central islands was observed in treated animals on day 21. New tissue formation accompanied by intense basophilia at the defect margins was seen in treated animals on day 21 and especially on day 3 [602.0, 175.0, 1083.0, 513.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
60 4 6 text Analysis of sections stained with picrosirius-hematoxylin and examined by bright-field microscopy under polarized light (Figure 2) showed a predominance of thick collagen fibers in the control group a [601.0, 513.0, 1083.0, 872.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
61 4 7 text Electron photomicrographs of the repair tissue treated by the tannic acid method are shown in Figure 3. Fibroblast-like cells were observed in control animals on days 7 and 21. These cells were surrou [602.0, 872.0, 1083.0, 971.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
62 4 8 image [252.0, 1007.0, 937.0, 1373.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
63 4 9 figure_title Figure 1 Photomicrographs of longitudinal sections of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 µA/5 min). Spe [115.0, 1377.0, 1068.0, 1462.0] figure_caption 0.92 ["figure_title label: Figure 1 Photomicrographs of longitudinal sections of the xi"] figure_caption 0.92 display_zone legend_like figure_number True True
64 5 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [107.0, 65.0, 675.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
65 5 1 number Page 5 of 9 [997.0, 64.0, 1082.0, 87.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
66 5 2 image [253.0, 187.0, 936.0, 911.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
67 5 3 figure_title Figure 2 Photomicrographs of sections stained with picrosirius-hematoxylin and analyzed by bright-field microscopy under polarized light (D-F and J-L). A-F: Control group; G-L: treated group. Specimen [116.0, 919.0, 1059.0, 984.0] figure_caption 0.92 ["figure_title label: Figure 2 Photomicrographs of sections stained with picrosiri"] figure_caption 0.92 display_zone legend_like figure_number True True
68 5 4 image [251.0, 1039.0, 938.0, 1391.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
69 5 5 figure_title Figure 3 Electron photomicrographs of the xiphoid cartilage defect area in 45-day-old male rats. A-C: Control group; D-F: group submitted to microcurrent stimulation (20 μA/5 min). Specimens were coll [115.0, 1398.0, 1065.0, 1462.0] figure_caption 0.92 ["figure_title label: Figure 3 Electron photomicrographs of the xiphoid cartilage "] figure_caption 0.92 display_zone legend_like figure_number True True
70 6 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [108.0, 65.0, 676.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
71 6 1 number Page 6 of 9 [997.0, 65.0, 1081.0, 87.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
72 6 2 text pericellular matrix that was looser than that seen in the region of the territorial matrix. In contrast, chondroblast-like cells characterized by cytoplasm rich in secretory vesicles and abundant roug [107.0, 176.0, 586.0, 633.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
73 6 3 text Figure 4 shows electron photomicrographs of the repair tissue submitted to cytochemical staining of PGs. Larger PG complexes were observed in treated animals on day 7 when compared to the control grou [106.0, 632.0, 586.0, 898.0] body_paragraph 0.9 ["figure caption candidate (body narrative): Figure 4 shows electron photomicrographs of the repair tissu"] figure_caption_candidate 0.9 display_zone legend_like figure_number True True
74 6 4 paragraph_title Discussion [108.0, 919.0, 216.0, 942.0] section_heading 0.9 ["explicit scholarly heading: Discussion"] section_heading 0.9 body_zone heading_like canonical_section_name True True
75 6 5 text Since non-articular cartilage defects and repair are uncommon in clinical practice, studies investigating these processes are important to gain insights into the reorganization of this tissue under di [106.0, 944.0, 586.0, 995.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
76 6 6 text these processes are important to gain insights into the reorganization of this tissue under different functional conditions of the joints. In a recent study, Moyer et al. [19] observed regeneration of [602.0, 176.0, 1084.0, 560.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
77 6 7 text In the present study, only a small amount of newly formed cartilage was observed at the defect margins in all treated animals after 35 days of uninterrupted microcurrent application. These findings ag [601.0, 561.0, 1083.0, 872.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
78 6 8 text Another relevant finding was the effect of microcurrent stimulation on the total number of fibroblast cells, which was higher in all treated animals when compared to the respective control group. In a [601.0, 872.0, 1083.0, 995.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
79 6 9 image [250.0, 1033.0, 946.0, 1390.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
80 6 10 figure_title Figure 4 Electron photomicrographs of sections from control (A-C) and treated (D-F) animals stained with cuprolinic blue for the detection of proteoglycans (PG). Specimens were collected 7 (A and D), [118.0, 1398.0, 1023.0, 1462.0] figure_caption 0.92 ["figure_title label: Figure 4 Electron photomicrographs of sections from control "] figure_caption 0.92 display_zone legend_like figure_number True True
81 7 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [107.0, 65.0, 676.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
82 7 1 number Page 7 of 9 [997.0, 65.0, 1081.0, 88.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
83 7 2 text organization of cartilage in treated animals may be the result of the beneficial effects of electrical stimulation on the production, maintenance and organization of ECM [6,31]. According to Aaron et [106.0, 176.0, 586.0, 369.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
84 7 3 text Another factor related to the effects of microcurrent stimulation is the induction of the proliferative and differentiation capacity of mesenchymal cells, which are found mainly in young animals [6,32 [106.0, 369.0, 587.0, 729.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
85 7 4 text The abundant presence of granulocytes in treated animals on days 7 and 21 is consistent with one of the most well-known effects of electrotherapy, particularly electrical current stimulation, i.e., th [107.0, 729.0, 587.0, 1209.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
86 7 5 text A larger number of birefringent fibers indicating a larger number of compacted collagen fibers were observed in control animals on day 35. The lack of an effect of electrical current stimulation on fi [106.0, 1208.0, 587.0, 1475.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
87 7 6 text of the healing process by increasing collagen fiber depos- ition, cell proliferation, growth factor concentration, and ATP levels. In addition to these observations, Kirsch and Mercola [40] suggest th [602.0, 176.0, 1083.0, 417.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
88 7 7 text Although the ideal parameters and type of electrical stimulation that is safe and efficient in promoting connective tissue repair, particularly cartilage repair $ [33,44] $, have not been established [602.0, 416.0, 1083.0, 585.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
89 7 8 text In contrast to collagen fibers, the number of elastic fibers seems to be little influenced by microcurrent treatment. Traces of these fibers were observed in the two groups and at the different time p [602.0, 585.0, 1082.0, 776.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
90 7 9 text Several studies on cartilage repair have shown that microcurrents tend to induce the formation of fibrocartilage in chondral defects, whereas osteochondral defects are filled with cartilage tissue sin [601.0, 776.0, 1083.0, 1112.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
91 7 10 text The adequate combination of collagen fibrils and fibers and highly hydrated PGs permits cartilage to withstand the functional requirements during normal activity [4,47]. In the present study, no diffe [602.0, 1112.0, 1084.0, 1475.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
92 8 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [108.0, 66.0, 675.0, 107.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
93 8 1 number Page 8 of 9 [998.0, 66.0, 1081.0, 87.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
94 8 2 text other hand, the number of stained PGs seems to indicate a positive effect of treatment on the deposition of these molecules in the tissue. [107.0, 177.0, 584.0, 247.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
95 8 3 text The predominance of chondroblast-like cells in the defect area of treated animals since the beginning of treatment highlights another important aspect of the effect of microcurrent stimulation on the [107.0, 248.0, 585.0, 514.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
96 8 4 paragraph_title Conclusion [109.0, 537.0, 217.0, 559.0] section_heading 0.9 ["explicit scholarly heading: Conclusion"] section_heading 0.9 body_zone heading_like canonical_section_name True True
97 8 5 text We demonstrated that microcurrent stimulation has shown beneficial effects during non-articular cartilage repair in prepuberal animals. However, the period of observation was not sufficient to evaluat [107.0, 562.0, 585.0, 729.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
98 8 6 paragraph_title Competing interests [110.0, 747.0, 249.0, 764.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Competing interests"] subsection_heading 0.6 body_zone body_like short_fragment True True
99 8 7 text The authors declare that they have no competing interest. [109.0, 764.0, 470.0, 783.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
100 8 8 paragraph_title Authors' contributions [109.0, 801.0, 263.0, 819.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Authors' contributions"] subsection_heading 0.6 body_zone body_like none True True
101 8 9 text CCC, DCZ and LMGN carried out experimental work, data collection and evaluation, literature search and manuscript preparation. JSM helped the surgical procedure and data collection. PPJ helped to prep [107.0, 819.0, 583.0, 929.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
102 8 10 paragraph_title Acknowledgements [110.0, 948.0, 245.0, 964.0] sub_subsection_heading 0.6 ["unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgements"] sub_subsection_heading 0.6 body_zone body_like short_fragment True True
103 8 11 text The authors thank the technicians of the Laboratory of Micromorphology, Centro Universitário Hermínio Ometto, UNIARARAS, and of the Laboratory of Electron Microscopy, Instituto de Biologia, Universida [108.0, 965.0, 579.0, 1039.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
104 8 12 paragraph_title Author details [110.0, 1055.0, 209.0, 1073.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Author details"] subsection_heading 0.6 body_zone body_like short_fragment True True
105 8 13 text ¹Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339 Araras, SP, Brazil. ²Departamento de Histologia e [109.0, 1073.0, 568.0, 1165.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
106 8 14 text Received: 2 August 2012 Accepted: 16 January 2013 Published: 19 January 2013 [109.0, 1182.0, 447.0, 1218.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
107 8 15 paragraph_title References [111.0, 1236.0, 188.0, 1254.0] reference_heading 0.9 ["references heading: References"] reference_heading 0.9 reference_zone unknown_like short_fragment True True
108 8 16 reference_content 1. Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW: Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. Eur Cell Mater 2008, 16(1):26–33. [111.0, 1256.0, 562.0, 1308.0] reference_item 0.85 ["reference content label: 1. Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW: C"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
109 8 17 reference_content 2. Brighton CT, Wang W, Clark CC: Up-regulation of matrix in bovine articular cartilage explants by electric fields. Biochem Biophys Res Commun 2006, 342:556–561. [110.0, 1310.0, 583.0, 1360.0] reference_item 0.85 ["reference content label: 2. Brighton CT, Wang W, Clark CC: Up-regulation of matrix in"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
110 8 18 reference_content 3. Negri S, Farinato S, Fila C, Pagliaro P, Bellomi A: Tissue engineering: chondrocyte cultures on type I collagen support. Cytohistological and immunohistochemical study. J Orthopaed Traumatol 2007, [111.0, 1362.0, 571.0, 1415.0] reference_item 0.85 ["reference content label: 3. Negri S, Farinato S, Fila C, Pagliaro P, Bellomi A: Tissu"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
111 8 19 reference_content 4. Brighton CT, Wang W, Clark CC: The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants. J Bone Joint Surg Am 2000, 90:833–838. [110.0, 1417.0, 579.0, 1470.0] reference_item 0.85 ["reference content label: 4. Brighton CT, Wang W, Clark CC: The effect of electrical f"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
112 8 20 reference_content 5. Newman AP: Articular Cartilage Repair. Am J Sports Med 1998, 26:309–324. [606.0, 181.0, 1076.0, 200.0] reference_item 0.85 ["reference content label: 5. Newman AP: Articular Cartilage Repair. Am J Sports Med 19"] reference_item 0.85 reference_like reference_numeric_dot True True
113 8 21 reference_content 6. Akanji OO, Lee DA, Bader DA: The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs. Biorheology 2008, 45:229–243. [606.0, 199.0, 1077.0, 251.0] reference_item 0.85 ["reference content label: 6. Akanji OO, Lee DA, Bader DA: The effects of direct curren"] reference_item 0.85 reference_like reference_numeric_dot True True
114 8 22 reference_content 7. Vidal BC: Cell and extracellular matrix interaction: a feedback theory based on molecular order recognition-adhesion events. Rev Med Unicamp 1993, 4:1–6. [605.0, 253.0, 1078.0, 306.0] reference_item 0.85 ["reference content label: 7. Vidal BC: Cell and extracellular matrix interaction: a fe"] reference_item 0.85 reference_like reference_numeric_dot True True
115 8 23 reference_content 8. Hall AC, Horwitz ER, Wilkins RJ: The cellular physiology of articular cartilage. Exp Physiol 1996, 81:535–545. [606.0, 307.0, 1032.0, 345.0] reference_item 0.85 ["reference content label: 8. Hall AC, Horwitz ER, Wilkins RJ: The cellular physiology "] reference_item 0.85 reference_like reference_numeric_dot True True
116 8 24 reference_content 9. Buckwalter JA, Mankin HJ: Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr Course Lect 1998, 47:477–486. [608.0, 345.0, 1036.0, 381.0] reference_item 0.85 ["reference content label: 9. Buckwalter JA, Mankin HJ: Articular cartilage: tissue des"] reference_item 0.85 reference_like reference_numeric_dot True True
117 8 25 reference_content 10. Hyttinen MM, Arokoskit JPA, Parkkinen JJ, Lammi MJ, Lapvetelainen T, Mauranent K, Király K, Tammi MJ, Helminen HJ: Age matters: collagen birefringence of superficial articular cartilage is increas [608.0, 382.0, 1071.0, 470.0] reference_item 0.85 ["reference content label: 10. Hyttinen MM, Arokoskit JPA, Parkkinen JJ, Lammi MJ, Lapv"] reference_item 0.85 reference_like reference_numeric_dot True True
118 8 26 reference_content 11. Carrington JL: Aging bone and cartilage: cross-cutting issues. Biochem Biophys Res Commun. 2005, 18:700–708. [608.0, 472.0, 1054.0, 507.0] reference_item 0.85 ["reference content label: 11. Carrington JL: Aging bone and cartilage: cross-cutting i"] reference_item 0.85 reference_like reference_numeric_dot True True
119 8 27 reference_content 12. Hennerbichler A, Rosenberger R, Arora R, Hennerbichler D: Biochemical, biomechanical and histological properties of osteoarthritic porcine knee cartilage: implications for osteochondral transplant [608.0, 509.0, 1074.0, 579.0] reference_item 0.85 ["reference content label: 12. Hennerbichler A, Rosenberger R, Arora R, Hennerbichler D"] reference_item 0.85 reference_like reference_numeric_dot True True
120 8 28 reference_content 13. Nixon AJ, Fortier LA: New Horizons in Articular Cartilage Repair. AAEP Proceedings 2001, 47:217–226. [608.0, 581.0, 1050.0, 615.0] reference_item 0.85 ["reference content label: 13. Nixon AJ, Fortier LA: New Horizons in Articular Cartilag"] reference_item 0.85 reference_like reference_numeric_dot True True
121 8 29 reference_content 14. Anraku Y, Mizuta H, Sei A, Kudo S, Nakamura E, Senba K, Hiraki Y: Analyses of early events during chondrogenic repair in rat full-thickness articular cartilages defects. J Bone Miner Metab 2009, 2 [608.0, 617.0, 1070.0, 670.0] reference_item 0.85 ["reference content label: 14. Anraku Y, Mizuta H, Sei A, Kudo S, Nakamura E, Senba K, "] reference_item 0.85 reference_like reference_numeric_dot True True
122 8 30 reference_content 15. Johnson TS, Xu JW, Zaporojan W, Mesa JM, Weinand C, Randolph MA, Bonassar LJ, Winograd JM, Yaremchuk MJ: Integrative repair of cartilage with articular and nonarticular chondrocytes. Tissue Eng 20 [608.0, 673.0, 1074.0, 724.0] reference_item 0.85 ["reference content label: 15. Johnson TS, Xu JW, Zaporojan W, Mesa JM, Weinand C, Rand"] reference_item 0.85 reference_like reference_numeric_dot True True
123 8 31 reference_content 16. Beris AE, Lykissas MG, Papageorgiou CD, Georgoulis AD: Advances in articular cartilage repair. J Care Injured 2005, 365:S14–S23. [609.0, 726.0, 1039.0, 761.0] reference_item 0.85 ["reference content label: 16. Beris AE, Lykissas MG, Papageorgiou CD, Georgoulis AD: A"] reference_item 0.85 reference_like reference_numeric_dot True True
124 8 32 reference_content 17. Redman SN, Oldfield SF, Archer CW: Current strategies for articular cartilage repair. Eur Cells Mater 2005, 9:23–32. [608.0, 763.0, 1033.0, 797.0] reference_item 0.85 ["reference content label: 17. Redman SN, Oldfield SF, Archer CW: Current strategies fo"] reference_item 0.85 reference_like reference_numeric_dot True True
125 8 33 reference_content 18. Etawil NM, Bari C, Achan P, Pitzalis C, Dell'Accio F: A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after surface injury. Osteoarthr Cartilage 2009, 17:6 [608.0, 800.0, 1070.0, 852.0] reference_item 0.85 ["reference content label: 18. Etawil NM, Bari C, Achan P, Pitzalis C, Dell'Accio F: A "] reference_item 0.85 reference_like reference_numeric_dot True True
126 8 34 reference_content 19. Moyer HR, Wang Y, Farooque T, Wick T, Singh KA, Xie L, Guldberg RE, Williams JK, Boyan BD, Schwartz Z: A new animal model for assessing cartilage repair and regeneration at a nonarticular site. Ti [607.0, 855.0, 1068.0, 924.0] reference_item 0.85 ["reference content label: 19. Moyer HR, Wang Y, Farooque T, Wick T, Singh KA, Xie L, G"] reference_item 0.85 reference_like reference_numeric_dot True True
127 8 35 reference_content 20. Stockwell RA: Lipid content of human costal and articular cartilage. Ann Rheum Dis 1967, 26:481–486. [607.0, 927.0, 1067.0, 960.0] reference_item 0.85 ["reference content label: 20. Stockwell RA: Lipid content of human costal and articula"] reference_item 0.85 reference_like reference_numeric_dot True True
128 8 36 reference_content 21. Souza TD, Del Carlo RJ, Viloria MIV: Histologic evaluation of the repair process in the articular surface of rabbits. Ciência Rural 2000, 30:439–444. [607.0, 963.0, 1070.0, 999.0] reference_item 0.85 ["reference content label: 21. Souza TD, Del Carlo RJ, Viloria MIV: Histologic evaluati"] reference_item 0.85 reference_like reference_numeric_dot True True
129 8 37 reference_content 22. Nieduszynski IA, Huckerby TN, Dickenson JM, Brown GM, Tai GH, Morris HG, Eady S: There are two major types of skeletal keratin sulphates. Biochem J 1990, 271:243–249. [607.0, 1000.0, 1079.0, 1051.0] reference_item 0.85 ["reference content label: 22. Nieduszynski IA, Huckerby TN, Dickenson JM, Brown GM, Ta"] reference_item 0.85 reference_like reference_numeric_dot True True
130 8 38 reference_content 23. Brown CJ, Caswell AM, Rahman S, Russell RS, Buttle DJ: Proteoglycan breakdown from bovine nasal cartilage is increased, and from articular cartilage is decreased, by extracellular ATP. Biochim Bio [607.0, 1054.0, 1066.0, 1125.0] reference_item 0.85 ["reference content label: 23. Brown CJ, Caswell AM, Rahman S, Russell RS, Buttle DJ: P"] reference_item 0.85 reference_like reference_numeric_dot True True
131 8 39 reference_content 24. Khubutiva MS, Yu I, Kliukvin LP, Istranov VB, Khvatov AB, Shekhter A, Vaza IV, Kanakov VS: Stimulation of regeneration of hyaline cartilage in experimental osteochondral injury. Bull Exp Biol Med [607.0, 1127.0, 1075.0, 1180.0] reference_item 0.85 ["reference content label: 24. Khubutiva MS, Yu I, Kliukvin LP, Istranov VB, Khvatov AB"] reference_item 0.85 reference_like reference_numeric_dot True True
132 8 40 reference_content 27. Bobic V: Current status of the articular cartilage repair. Orthop Knee Surg 2000, 13:37–42. [607.0, 1254.0, 1066.0, 1289.0] reference_item 0.85 ["reference content label: 27. Bobic V: Current status of the articular cartilage repai"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
133 8 41 reference_content 28. Haddad JB, Obolensky AG, Shinnick P: The biology effects and the therapeutic mechanism of action of electric and electromagnetic field stimulation on bone cartilage: new findings and review of ear [607.0, 1291.0, 1066.0, 1361.0] reference_item 0.85 ["reference content label: 28. Haddad JB, Obolensky AG, Shinnick P: The biology effects"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
134 8 42 reference_content 29. Scott JE, Haigh M, Nusgens B, Lapière CM: Proteoglycan: collagen interactions in dermatosparactic skin and tendon. An electron histochemical study using cupromeronic blue in a critical electrolyte [606.0, 1363.0, 1052.0, 1434.0] reference_item 0.85 ["reference content label: 29. Scott JE, Haigh M, Nusgens B, Lapi\u00e8re CM: Proteoglycan: "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
135 8 43 reference_content 30. Baker B, Spadaro J, Marino A, Becker RO: Electrical stimulation of articular cartilage regeneration. Ann NY Acad Sci 1974, 238:491–499. [607.0, 1436.0, 1067.0, 1470.0] reference_item 0.85 ["reference content label: 30. Baker B, Spadaro J, Marino A, Becker RO: Electrical stim"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
136 9 0 header de Campos Ciccone et al. BMC Complementary and Alternative Medicine 2013, 13:17 http://www.biomedcentral.com/1472-6882/13/17 [109.0, 66.0, 675.0, 107.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
137 9 1 number Page 9 of 9 [997.0, 65.0, 1081.0, 87.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
138 9 2 reference_content 31. Lai WM, Sun GA, Ateshian XE, Mow VC: Electrical signals for chondrocytes in cartilage. Biorheology 2002, 39(1):39–45. [111.0, 181.0, 576.0, 216.0] reference_item 0.85 ["reference content label: 31. Lai WM, Sun GA, Ateshian XE, Mow VC: Electrical signals "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
139 9 3 reference_content 32. Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ: Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop Rel Res 2004, 419(1):30–37. [111.0, 217.0, 563.0, 269.0] reference_item 0.85 ["reference content label: 32. Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ: St"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
140 9 4 reference_content 33. Nogami H, Aoki BE, Okagawa T, Mimatsu K: Effects of electric current on chondrogenesis in vitro. Basic science and pathology. Clin Orthop Rel Res 1982, 163:243–247. [112.0, 271.0, 574.0, 322.0] reference_item 0.85 ["reference content label: 33. Nogami H, Aoki BE, Okagawa T, Mimatsu K: Effects of elec"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
141 9 5 reference_content 34. Aaron RK, MacK D, Ciombor DM, Simon BJ: Treatment of nonunions with electric and electromagnetic fields. Clin Orthop 2004, 419(1):21–29. [112.0, 325.0, 571.0, 360.0] reference_item 0.85 ["reference content label: 34. Aaron RK, MacK D, Ciombor DM, Simon BJ: Treatment of non"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
142 9 6 reference_content 35. Westers BM: Review of the repair of defects in articular cartilage. JOSPT 1982, 4:6–15. [112.0, 361.0, 568.0, 395.0] reference_item 0.85 ["reference content label: 35. Westers BM: Review of the repair of defects in articular"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
143 9 7 reference_content 36. Oikhana H, Shimomura Y: Effect of direct current on cultured growth cartilage cells in vitro. J Orthop Res 1988, 6:690–694. [112.0, 397.0, 553.0, 432.0] reference_item 0.85 ["reference content label: 36. Oikhana H, Shimomura Y: Effect of direct current on cult"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
144 9 8 reference_content 37. Davis P: Microcurrent. A modern healthcare modality. Rehab Ther Prod Rev 1992, 10:62–66. [112.0, 433.0, 581.0, 468.0] reference_item 0.85 ["reference content label: 37. Davis P: Microcurrent. A modern healthcare modality. Reh"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
145 9 9 reference_content 38. Sonnewend D, Oliveira JLR, Nicolau RA, Zângaro RA, Pacheco MTT: [112.0, 469.0, 531.0, 485.0] reference_item 0.85 ["reference content label: 38. Sonnewend D, Oliveira JLR, Nicolau RA, Z\u00e2ngaro RA, Pache"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
146 9 10 reference_content Avaliação do efeito da microterapia celular (microcorrentes) sobre o processo inicial da cicatrização de feridas em ratos. In XI INIC Encontro Latino Americano de Iniciação Científica e V EPG Encontro [112.0, 481.0, 572.0, 575.0] reference_item 0.85 ["reference content label: Avalia\u00e7\u00e3o do efeito da microterapia celular (microcorrentes)"] reference_item 0.85 reference_zone reference_like none True True
147 9 11 reference_content 39. Lee BY, Wendell K, Al-Waili N, Butler G: Ultra-low microcurrent therapy: a novel approach for treatment of chronic resistant wounds. Adv Ther 2007, 24:1202–1209. [112.0, 577.0, 582.0, 629.0] reference_item 0.85 ["reference content label: 39. Lee BY, Wendell K, Al-Waili N, Butler G: Ultra-low micro"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
148 9 12 reference_content 40. Kirsch DL, Mercola JM: The basis for microcurrent electrical therapy in conventional medical practice. J Adv Med 1995, 8:83–97. [112.0, 630.0, 561.0, 667.0] reference_item 0.85 ["reference content label: 40. Kirsch DL, Mercola JM: The basis for microcurrent electr"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
149 9 13 reference_content 41. Cheng N, Hoof HV, Bock E, Hoogmartens MJ, Mulier JC, Ducker FJ, Sansen WM, Loecker W: The effect of electric current on ATP generation, protein synthesis, membrane transport in rat skin. Clin Orth [111.0, 668.0, 577.0, 737.0] reference_item 0.85 ["reference content label: 41. Cheng N, Hoof HV, Bock E, Hoogmartens MJ, Mulier JC, Duc"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
150 9 14 reference_content 42. Nordenstrom B: Biologically Closed Electrical Circuits. Uppsala: Nordic Medical Publications; 1983. [111.0, 738.0, 578.0, 774.0] reference_item 0.85 ["reference content label: 42. Nordenstrom B: Biologically Closed Electrical Circuits. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
151 9 15 reference_content 43. Chao P-H, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT: Chondrocyte translocation response to direct current electric fields. J Biomech Eng 2000, 122:261–267. [110.0, 776.0, 554.0, 827.0] reference_item 0.85 ["reference content label: 43. Chao P-H, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT: Ch"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
152 9 16 reference_content 44. Dodge GR, Bowen JR, Wug OHC, Tokmakova K, Simon BJ, Aroojis A, Potter K: Electrical stimulation of the growth plate: a potential approach to an epiphysiodesis. Bioelectromagnetics 2007, 28:463–470 [111.0, 829.0, 572.0, 882.0] reference_item 0.85 ["reference content label: 44. Dodge GR, Bowen JR, Wug OHC, Tokmakova K, Simon BJ, Aroo"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
153 9 17 reference_content 45. Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct current-induced repair of articular cartilage in rabbit osteochondral defects. J Orthop Res 1990, 8:266–275. [111.0, 883.0, 571.0, 935.0] reference_item 0.85 ["reference content label: 45. Lippiello L, Chakkalakal D, Connolly JF: Pulsing direct "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
154 9 18 reference_content 46. Black J: Electrical Stimulation of Hard and Soft Tissue in Animal Models. Clin Plast Surg 1985, 12:243–257. [111.0, 937.0, 572.0, 972.0] reference_item 0.85 ["reference content label: 46. Black J: Electrical Stimulation of Hard and Soft Tissue "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
155 9 19 reference_content 47. Reichenberger E, Olsen BR: Collagens as organizers of extracellular matrix during morphogenesis. Semin Cell Dev Biol 1996, 7:631–638. [112.0, 973.0, 577.0, 1008.0] reference_item 0.85 ["reference content label: 47. Reichenberger E, Olsen BR: Collagens as organizers of ex"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
156 9 20 reference_content 48. Takei N, Akai M: Effect of direct current stimulation on triradiate physeal cartilage. In vivo study in young rabbits. Arch Orthop Trauma Surg 1993, 112:159–162. [113.0, 1010.0, 574.0, 1061.0] reference_item 0.85 ["reference content label: 48. Takei N, Akai M: Effect of direct current stimulation on"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
157 9 21 text doi:10.1186/1472-6882-13-17 Cite this article as: de Campos Ciccone et al.: Effects of microcurrent stimulation on Hyaline cartilage repair in immature male rats (Rattus norvegicus). BMC Complementary [118.0, 1084.0, 550.0, 1154.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none True True
158 9 22 paragraph_title Submit your next manuscript to BioMed Central and take full advantage of: [642.0, 1213.0, 1049.0, 1259.0] structured_insert 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Submit your next manuscript to BioMed Central and take full "] subsection_heading 0.6 tail_nonref_hold_zone unknown_like none False False
159 9 23 text • Convenient online submission [641.0, 1280.0, 850.0, 1299.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none False False
160 9 24 text • Thorough peer review [640.0, 1305.0, 801.0, 1324.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none False False
161 9 25 text • No space constraints or color figure charges [640.0, 1330.0, 938.0, 1350.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none False False
162 9 26 text • Immediate publication on acceptance [641.0, 1356.0, 897.0, 1374.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none False False
163 9 27 text • Inclusion in PubMed, CAS, Scopus and Google Scholar [641.0, 1380.0, 1001.0, 1399.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none False False
164 9 28 text • Research which is freely available for redistribution [641.0, 1404.0, 987.0, 1424.0] structured_insert 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none False False
165 9 29 footer Submit your manuscript at www.biomedcentral.com/submit [642.0, 1449.0, 839.0, 1480.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False
166 9 30 footer_image [904.0, 1448.0, 1050.0, 1478.0] structured_insert 0.2 ["unrecognized label 'footer_image'"] unknown_structural 0.2 unknown_like empty False False

63
audit/2BYRLKQS/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,63 @@
{
"figures": {
"matched_count": 4,
"ambiguous_count": 0,
"unresolved_cluster_count": 0,
"unmatched_asset_count": 0,
"matched": [
{
"figure_number": 1,
"legend_block_id": 9,
"asset_block_ids": [
8
],
"page": 4,
"match_type": null
},
{
"figure_number": 2,
"legend_block_id": 3,
"asset_block_ids": [
2
],
"page": 5,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 5,
"asset_block_ids": [
4
],
"page": 5,
"match_type": null
},
{
"figure_number": 4,
"legend_block_id": 10,
"asset_block_ids": [
9
],
"page": 6,
"match_type": null
}
],
"ambiguous": [],
"unresolved": []
},
"tables": {
"matched_count": 1,
"ambiguous_count": 0,
"unmatched_asset_count": 0,
"matched": [
{
"table_number": 1,
"caption_block_id": 2,
"asset_block_ids": [],
"page": 4,
"match_status": "matched"
}
],
"ambiguous": []
}
}

1447
audit/2BYRLKQS/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

210
audit/2BYRLKQS/page_risk_summary.json Normal file
View file

@ -0,0 +1,210 @@
{
"pages": [
{
"page": 1,
"risk_score": 7,
"risk_reasons": [
"frontmatter_page",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"frontmatter"
],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 2,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 8,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 3,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 8,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 4,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 2,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 5,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 2,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 3,
"risk_reasons": [
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 1,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 7,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 9,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 8,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 8,
"reference_item": 28,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 9,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 1,
"reference_item": 19,
"tail_like": 8,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
4,
5,
6,
8,
9
]
}

263
audit/2BYRLKQS/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,263 @@
{
"candidates": [
{
"block_id": "p8:15",
"page": 8,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:16",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:17",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:18",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:19",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:20",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:21",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:22",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:23",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:24",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:25",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:26",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:27",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:28",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:29",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:30",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:0",
"page": 9,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:1",
"page": 9,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:2",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:3",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:4",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:5",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:6",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:7",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:8",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:9",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:10",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:11",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:12",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:13",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:14",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:15",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:16",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:17",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:18",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:19",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:20",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

384
audit/2BYRLKQS/reference_span_audit.json Normal file
View file

@ -0,0 +1,384 @@
{
"reference_span": {
"status": "ACCEPT",
"span_id": "refspan_001",
"start": {
"page": 8,
"column": 1,
"y": 1236.0,
"block_id": "p8:15"
},
"end": {
"page": 9,
"column": 1,
"y": 1010.0,
"block_id": "p9:20"
},
"heading_block_id": "p8:15",
"ordered_block_ids": [
"p8:15",
"p8:16",
"p8:17",
"p8:18",
"p8:19",
"p8:20",
"p8:21",
"p8:22",
"p8:23",
"p8:24",
"p8:25",
"p8:26",
"p8:27",
"p8:28",
"p8:29",
"p8:30",
"p8:31",
"p8:32",
"p8:33",
"p8:34",
"p8:35",
"p8:36",
"p8:37",
"p8:38",
"p8:39",
"p8:40",
"p8:41",
"p8:42",
"p8:43",
"p9:2",
"p9:3",
"p9:4",
"p9:5",
"p9:6",
"p9:7",
"p9:8",
"p9:9",
"p9:10",
"p9:11",
"p9:12",
"p9:13",
"p9:14",
"p9:15",
"p9:16",
"p9:17",
"p9:18",
"p9:19",
"p9:20"
],
"inside_block_ids": [
"p8:15",
"p8:16",
"p8:17",
"p8:18",
"p8:19",
"p8:20",
"p8:21",
"p8:22",
"p8:23",
"p8:24",
"p8:25",
"p8:26",
"p8:27",
"p8:28",
"p8:29",
"p8:30",
"p8:31",
"p8:32",
"p8:33",
"p8:34",
"p8:35",
"p8:36",
"p8:37",
"p8:38",
"p8:39",
"p8:40",
"p8:41",
"p8:42",
"p8:43",
"p9:2",
"p9:3",
"p9:4",
"p9:5",
"p9:6",
"p9:7",
"p9:8",
"p9:9",
"p9:10",
"p9:11",
"p9:12",
"p9:13",
"p9:14",
"p9:15",
"p9:16",
"p9:17",
"p9:18",
"p9:19",
"p9:20"
],
"explicitly_outside_nearby_block_ids": [
"p8:14",
"p9:21"
],
"intrusion_candidates": [
{
"block_id": "p8:15",
"page": 8,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:16",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:17",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:18",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:19",
"page": 8,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:20",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:21",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:22",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:23",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:24",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:25",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:26",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:27",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:28",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:29",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p8:30",
"page": 8,
"role": "reference_item",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:0",
"page": 9,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:1",
"page": 9,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:2",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:3",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:4",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:5",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:6",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:7",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:8",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:9",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:10",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:11",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:12",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:13",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:14",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:15",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:16",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:17",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:18",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:19",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p9:20",
"page": 9,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}
}

537
audit/2E4EPHN2/audit_report.json Normal file
View file

@ -0,0 +1,537 @@
{
"paper_key": "2E4EPHN2",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:8b6c43d69561e50ad4924bc1b69519541c63b3225185d4a13d312faa186659d9",
"meta_json_hash": "sha256:c8471095eeeb5e88e36a1434f6e00890f76753d1a0c699782bcb367bc6add12d",
"blocks_raw_hash": "sha256:4c5676a32747d2aebb848480dbdaf6698e27496e6a4be00f70d4805ae75b3f96",
"structured_blocks_hash": "sha256:6a16b10ce539b74ce210f45981cea2095e07439b5536d0e2bf391ad096cfcbe6",
"document_structure_hash": "sha256:c8c73bc069cde2b6d7a30ccfcebf241c306425ec4841a576f53db1de20d356d5",
"figure_inventory_hash": "sha256:42ea43b848ab7296588834a773d80441d3fbf4c5205b241a769d0f2bfdb3bc49",
"table_inventory_hash": "sha256:ac63f303629cbbad7a08dc06c05a7394f23e9e0e9eda4207569076e61ad8538b",
"reader_figures_hash": "sha256:e75165dba654e347b9d934b3c1873e7b17a8a8dfdd66c92cac69ab8ad8e08104",
"resolved_metadata_hash": "sha256:3a395afac39c65f822277b32c17005e7c96a734e6233b254ca5e78f70a9cf4ae",
"fulltext_hash": "sha256:bbd8ba51c67e9632328947ce97a9f239e9b646510e08ffc3cea16bb8608248ef",
"block_trace_hash": "sha256:eba4426cc0aa3a766befb1e4b0414c9d2d86ec15c80dc660741143c9e39c7600",
"annotated_pages": {
"page_001.png": "sha256:9905afcfd8fbf009bef5a20ca1f8184385223b0f7a43979fab25ae3d61ebf256",
"page_002.png": "sha256:c9b22362a802590903b861b509a1037823b477cd1a1d293d25e6893370d9b2a4",
"page_003.png": "sha256:c4bd8c67dce36fb70ad0382417d07a2b0b38c98117e00a336759a980a0bd22aa",
"page_004.png": "sha256:1041866c497007d963bba0306a3618ebfc33e3b26f1b026b779608931b5d72fc",
"page_005.png": "sha256:df900ec3e58f216f14f186c36c08116121aa597f6870438f0198a9ff3dc3c9ec",
"page_006.png": "sha256:4101460df9f91c42767d5544d46d4e4fa6d0dd2def1ebb6f6eca5c01e5171803",
"page_007.png": "sha256:ba5f69881ca72fbc8e8184fe29f66ac831b6d98b452cfca8d265d7cc032b0ed5",
"page_008.png": "sha256:bcfc27fb120af406d128b8bf9fb3f5f6dd17d6ead3251b8ee04aa61755b58586",
"page_009.png": "sha256:9c116c080c4fbe7921f7e9a11d7d71daffdd9794826efbc6c8c21c8b16df86b7",
"page_010.png": "sha256:447babd080056aeb2792352a20c9ade024e2cbe7129408503e6aed4c72c76032",
"page_011.png": "sha256:f5f448f81ffdae19e7346aea126592f785439d0ac55371900aeeb59409bf66c0",
"page_012.png": "sha256:237e9abba04d205456eb973a0edebc44aa00ee581cd88372f49df13746636e4d",
"page_013.png": "sha256:bd1d8f6d82aaf0d12261aee4bae585779e737e531b21d7c43f86b9746c1ce87e",
"page_014.png": "sha256:3fd23c79a891205b1b7cd59f8b1d9bb1ddfa2ce715ce6d264730a377a97e175a",
"page_015.png": "sha256:1b138f0279ab8eb53c8b559c24d16549a8d42d862120f9779cf939f8deb1da68"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png",
"page_008.png",
"page_009.png",
"page_010.png",
"page_011.png",
"page_012.png",
"page_013.png",
"page_014.png",
"page_015.png"
]
},
"reviewed_pages": [
1,
5,
6,
7,
8,
9,
11,
12
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p1:18",
"p1:19",
"p1:20",
"p1:21",
"p1:22",
"p1:23",
"p5:0",
"p5:1",
"p5:2",
"p5:3",
"p5:4",
"p5:5",
"p5:6",
"p5:7",
"p5:8",
"p5:9",
"p5:10",
"p6:0",
"p6:1",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p6:12",
"p6:13",
"p6:14",
"p7:0",
"p7:1",
"p7:2",
"p7:3",
"p7:4",
"p7:5",
"p7:6",
"p7:7",
"p7:8",
"p7:9",
"p7:10",
"p7:11",
"p7:12",
"p7:13",
"p7:14",
"p7:15",
"p7:16",
"p7:17",
"p7:18",
"p8:0",
"p8:1",
"p8:2",
"p8:3",
"p8:4",
"p8:5",
"p8:6",
"p8:7",
"p8:8",
"p8:9",
"p8:10",
"p8:11",
"p8:12",
"p8:13",
"p8:14",
"p8:15",
"p8:16",
"p8:17",
"p9:0",
"p9:1",
"p9:2",
"p9:3",
"p9:4",
"p9:5",
"p9:6",
"p9:7",
"p9:8",
"p9:9",
"p9:10",
"p9:11",
"p9:12",
"p9:13",
"p9:14",
"p9:15",
"p9:16",
"p9:17",
"p11:0",
"p11:1",
"p11:2",
"p11:3",
"p11:4",
"p11:5",
"p11:6",
"p11:7",
"p11:8",
"p11:9",
"p12:0",
"p12:1",
"p12:2",
"p12:3",
"p12:4",
"p12:5",
"p12:6",
"p12:7",
"p12:8",
"p12:9",
"p12:10",
"p12:11",
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p12:16",
"p12:17",
"p12:18",
"p12:19",
"p12:20"
],
"findings": [
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:11"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:12"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:13"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:14"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:15"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:16"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:17"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:18"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:19"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p12:20"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:0"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:1"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:2"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:3"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:4"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:5"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:6"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:7"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:8"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "reference_span_error",
"severity": "critical",
"block_ids": [
"p13:9"
],
"truth": "block should remain outside the accepted reference span",
"pipeline_behavior": "block appears inside the logical reference reading-order region",
"root_cause_hypothesis": "logical_order_between_reference_members",
"evidence": {
"annotated_page": "annotated_pages/page_013.png",
"artifact": "reference_span_audit.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_012.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:22",
"p1:23",
"p2:0",
"p2:1",
"p3:0",
"p3:1",
"p3:7",
"p3:14",
"p4:0",
"p4:1",
"p4:3",
"p5:0",
"p5:1",
"p6:0"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

37
audit/2E4EPHN2/audit_report.md Normal file
View file

@ -0,0 +1,37 @@
# OCR Truth Audit Report - 2E4EPHN2
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 5, 6, 7, 8, 9, 11, 12]
- Reviewed blocks: 136
## Findings
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

1165
audit/2E4EPHN2/audit_scope.json Normal file
View file

File diff suppressed because it is too large Load diff

5080
audit/2E4EPHN2/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

262
audit/2E4EPHN2/block_trace.csv Normal file
View file

@ -0,0 +1,262 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,header_image,,"[70.0, 101.0, 139.0, 167.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False
1,1,header,antioxidants,"[146.0, 114.0, 352.0, 155.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,support_like,short_fragment,False,False
1,2,header_image,,"[1030.0, 109.0, 1119.0, 168.0]",non_body_insert,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,False
1,3,text,Article,"[65.0, 208.0, 131.0, 231.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,frontmatter_main_zone,support_like,short_fragment,False,False
1,4,doc_title,Microcurrent and Gold Nanoparticles Combined with Hyaluronic Acid Accelerates Wound Healing,"[65.0, 232.0, 959.0, 313.0]",paper_title,0.8,"[""page-1 zone title_zone: Microcurrent and Gold Nanoparticles Combined with Hyaluronic""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True
1,5,text,"Carolini Mendes 1,2, Anand Thirupathi 1,*⊕, Rubya Pereira Zaccaron 2, Maria Eduardo Anastácio Borges Corrêa 2, João V. S. Bittencourt 2, Laura de Roch Casagrande 2, Anadhelly C. S. de Lima 2, Lara L. ","[64.0, 334.0, 1108.0, 437.0]",authors,0.8,"[""page-1 zone author_zone: Carolini Mendes 1,2, Anand Thirupathi 1,*\u2295, Rubya Pereira Za""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True
1,6,text," $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningbo 315211, China","[326.0, 478.0, 842.0, 501.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningb""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,7,text," $ ^{2} $ Laboratory of Experimental Phisiopatology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Cricúima 88806-000, Brazil","[326.0, 501.0, 1121.0, 543.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $ Laboratory of Experimental Phisiopatology, Program ""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,8,text," $ ^{3} $ Graduate Program of Biomedical Science, Herminio Ometto Foundation, Araras 13607-339, Brazil","[327.0, 544.0, 1051.0, 566.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{3} $ Graduate Program of Biomedical Science, Herminio Om""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,9,image,,"[69.0, 733.0, 178.0, 770.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,frontmatter_main_zone,support_like,empty,True,True
1,10,text,"Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corrêa, M.E.A.B.; Bittencourt, J.V.S.; Casagrande, L.d.R.; de Lima, A.C.S.; de Oliveira, L.L.; de Andrade, T.A.M.; Gu, Y.; et al. Microcurrent and","[65.0, 778.0, 308.0, 1037.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corr\u00eaa""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,11,image,,"[69.0, 1313.0, 185.0, 1353.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
1,12,text,Academic Editor: Reinhart M. Speeckaert,"[67.0, 1052.0, 260.0, 1097.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic Editor: Reinhart M. Speeckaert""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,13,text,"Received: 16 September 2022
Accepted: 7 November 2022
Published: 15 November 2022","[67.0, 1114.0, 259.0, 1183.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Received: 16 September 2022\nAccepted: 7 November 2022\nPublis""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,14,text,"Publisher's Note: MDPI stays neutral
with regard to jurisdictional claims in
published maps and institutional affiliations.
* Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.)","[66.0, 1197.0, 307.0, 1289.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Publisher's Note: MDPI stays neutral\nwith regard to jurisdic""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,15,text,* Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.),"[327.0, 567.0, 885.0, 589.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: * Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.n""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,16,text,"Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen","[66.0, 1363.0, 309.0, 1551.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Copyright: \u00a9 2022 by the authors. Licensee MDPI, Basel, Swit""]",frontmatter_noise,0.8,body_zone,support_like,none,False,False
1,17,abstract,Abstract: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. Fifty Wistar rats (n = 10,"[326.0, 614.0, 1125.0, 1105.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,18,text,Keywords: wound healing; iontophoresis; gold nanoparticles; hyaluronic acid; inflammation,"[327.0, 1133.0, 1072.0, 1158.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Keywords: wound healing; iontophoresis; gold nanoparticles; ""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,19,paragraph_title,1. Introduction,"[328.0, 1232.0, 473.0, 1255.0]",section_heading,0.85,"[""paragraph_title label with numbering: 1. Introduction""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
1,20,text,"Currently, the prevalence of non-healing wounds in developed countries is 1 to 2%, and this rate is significantly increased in underdeveloped countries. However, this problem affects the population in","[325.0, 1263.0, 1125.0, 1462.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,21,text,"New materials and approaches are urgently desirable for wound healing since current treatments are closely restricted to bed hygiene and dressing changes; although essential, in some situations, these","[324.0, 1464.0, 1126.0, 1542.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,22,footer,"Antioxidants 2022, 11, 2257. https://doi.org/10.3390/antiox11112257","[66.0, 1625.0, 557.0, 1647.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
1,23,footer,https://www.mdpi.com/journal/antioxidants,"[784.0, 1625.0, 1122.0, 1648.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
2,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False
2,1,header,2 of 15,"[1068.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_numeric_dot,False,False
2,2,text,"it is important to develop other approaches that accelerate the acute inflammatory and re-epithelialization process, thus avoiding complications and excessive expenditures in the health system [6,7].","[325.0, 192.0, 1123.0, 266.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,3,text,"A microcurrent (MC) or a microgalvanic current is an electrical current in the range of microamperes ( $ \mu $A), polarized and continuous, and it promotes a physical stimulus and is non-invasive, non","[326.0, 268.0, 1125.0, 468.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,4,text,"Furthermore, through electrophoresis and electro-osmosis, MC allows the passage of charged and uncharged biomolecules across biological membranes. Iontophoresis is the collective name for these two pr","[326.0, 469.0, 1124.0, 669.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,5,text,"Currently, the development of nanomaterials, such as gold nanoparticles (GNPs), represents a promising approach to wound care [17]. Due to their focused delivery, lower toxicity, and higher absorption","[326.0, 670.0, 1124.0, 921.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,6,text,"Hyaluronic acid (HA) is a component of the extracellular matrix, and it has excellent benefits for the treatment of dermal and epidermal lesions [22]. Its capacity to promote the production of fibrin,","[325.0, 920.0, 1124.0, 1274.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,7,paragraph_title,2. Materials and Methods,"[328.0, 1291.0, 569.0, 1315.0]",section_heading,0.85,"[""paragraph_title label with numbering: 2. Materials and Methods""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
2,8,paragraph_title,2.1. Animals,"[328.0, 1318.0, 443.0, 1342.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.1. Animals""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
2,9,text,"All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (Bethesda, MD, USA) and with t","[326.0, 1349.0, 1123.0, 1474.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,10,text,"Fifty Wistar male rats (60 days old, weighing between 250 and 300 g) were used, and they were kept at a controlled room temperature between $ 20 \pm 22\ ^{\circ}\mathrm{C} $, under a light-dark","[326.0, 1475.0, 1123.0, 1527.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
3,1,number,3 of 15,"[1068.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
3,2,text,"cycle 12/12 h, and with free access to water and food. Male rats were used so that there were no changes in the inflammatory analysis due to hormones.","[324.0, 192.0, 1122.0, 242.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,3,text,The animals were randomly assigned to five experimental groups with n = 10/group: excisional wound (EW) group—without local or systemic treatment; the EW + microcurrent treatment (EW + MC) group (300 ,"[326.0, 244.0, 1124.0, 369.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,4,paragraph_title,2.2. Excisional Wound Model,"[328.0, 387.0, 578.0, 410.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.2. Excisional Wound Model""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,5,text,"The wound model was made using a circular excision as described by Mendes [21]. The animals were anesthetized with 4% isoflurane. The dorsal region of each animal was shaved, cleaned, and disinfected ","[325.0, 417.0, 1125.0, 546.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,6,paragraph_title,2.3. Treatment,"[328.0, 564.0, 455.0, 588.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.3. Treatment""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,7,text,"The animals received microcurrent treatment using a Ibramed Striat Esthetic $ ^{\circledR} $ (Ibramed, São Paulo, Brazil) device with the function of a microgalvanic ( $ \mu $A) current lasting 20 min","[326.0, 594.0, 1125.0, 720.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,8,text,"The first treatment session started 24 h after the injury, and the others were performed daily until the seventh day. The area treated with iontophoresis was the dorsal region, which was submitted to ","[326.0, 720.0, 1124.0, 848.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,9,paragraph_title,2.4. Euthanasia,"[328.0, 865.0, 465.0, 890.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.4. Euthanasia""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,10,text,"The animals were euthanized 12 h after the last application of the MC, HA, and/or GNPs. After that, the external border of the wound was surgically removed and immediately processed and stored in a fr","[326.0, 897.0, 1124.0, 974.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,11,paragraph_title,2.5. Synthesis and Characterization of the GNPs,"[328.0, 992.0, 728.0, 1017.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.5. Synthesis and Characterization of the GNPs""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,12,text,"Next, 20 nm GNPs were synthesized using the Turkevish method adapted by Della Vechia et al. [25]. The GNP solution was characterized using ultraviolet–visible (UV–VIS) spectroscopy with a spectrophoto","[325.0, 1023.0, 1124.0, 1199.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,13,paragraph_title,2.6. Wound Size Analysis,"[328.0, 1217.0, 546.0, 1242.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.6. Wound Size Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,14,text,"Digital images of the wounds were taken at a resolution of $ 3264 \times 2448 $ pixels and analyzed using ImageJ $ ^{\textregistered} $ 1.51 software (National Institute of Mental Health, Bethesda, M","[326.0, 1249.0, 1124.0, 1400.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,15,paragraph_title,2.7. Histomorphometry,"[328.0, 1420.0, 526.0, 1445.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.7. Histomorphometry""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
3,16,text,"The wound samples of four animals per group were conditioned for 48 h in a 10% formaldehyde-buffered solution (pH 7.4 phosphate buffer), followed by histological processing, and they were then embedde","[326.0, 1450.0, 1124.0, 1553.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
4,1,number,4 of 15,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
4,2,text,"inflammatory infiltrate, blood vessels, and fibroblasts. Moreover, Ponceau S staining was performed to quantify the percentage area of total collagen compaction [29–32].","[325.0, 192.0, 1122.0, 242.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,3,text,"Furthermore, all histological sections were visualized using a LEICA $ ^{\circledR} $ DM-2000B optical microscope with a LEICA $ ^{\circledR} $ DFC-300 FX (Leica Microsystems, Wetzlar, Germany) camera","[326.0, 242.0, 1123.0, 341.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,4,text,"For a simultaneous quantification (evaluated by a trained pathologist) of the inflammatory infiltrate and fibroblasts, the “Cell Counter” plugin in ImageJ software (5 images/animal/time/treatment in 4","[326.0, 343.0, 1126.0, 520.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,5,paragraph_title,2.8. Determination of Cytokine Content Using ELISA,"[328.0, 537.0, 774.0, 562.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.8. Determination of Cytokine Content Using ELISA""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,6,text,"The samples were processed, and then the plate was sensitized for further incubation with the antibody. To measure cytokines (IFN $ \gamma $, TNF- $ \alpha $, IL-1 $ \beta $, IL-6, IL-4, IL-10, TGF- $","[326.0, 569.0, 1124.0, 671.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,7,paragraph_title,2.9. Biochemical Analysis,"[328.0, 688.0, 545.0, 713.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.9. Biochemical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,8,text,"Tissue determination of Reactive Oxygen Species (ROS) and nitric oxide: The production of hydroperoxides was determined by the intracellular formation of 2',7' dichlorofluorescein (DCF) by ROS as desc","[326.0, 720.0, 1124.0, 820.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,9,text,Tissue determination of oxidative damage marker levels: The oxidative damage to protein in the homogenized skin tissue samples was measured by the determination of carbonyl groups. The total thiol con,"[326.0, 822.0, 1124.0, 920.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,10,text,"Tissue determination of antioxidant defenses: SOD was measured in homogenized skin tissue by the inhibition of adrenaline oxidation, which was adapted from Bannister and Calabrese [35]. A standard cur","[326.0, 921.0, 1123.0, 1020.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,11,text,Protein Content: The protein content in homogenized skin tissue was measured following the protocol from Corrêa et al. [34].,"[327.0, 1021.0, 1121.0, 1072.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,12,paragraph_title,2.10. Statistical Analysis,"[328.0, 1091.0, 540.0, 1115.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 2.10. Statistical Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,13,text,"Data are expressed as the mean ± standard error, and they were analyzed statistically using one-way analysis of variance (ANOVA) tests, followed by Tukey's post hoc tests. The significance level for t","[326.0, 1122.0, 1123.0, 1225.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,14,paragraph_title,3. Results,"[328.0, 1244.0, 426.0, 1266.0]",section_heading,0.85,"[""paragraph_title label with numbering: 3. Results""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,15,paragraph_title,3.1. Physicochemical Properties of the GNP Solution,"[328.0, 1269.0, 760.0, 1295.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.1. Physicochemical Properties of the GNP Solution""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
4,16,text,"To evaluate the formation and physical–chemical properties of the GNPs, UV–VIS, DLS, and zeta potential analyses were performed. The GNPs presented a maximum absorption peak at 524 nm and a ruby red c","[326.0, 1301.0, 1124.0, 1501.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
5,1,number,5 of 15,"[1069.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
5,2,chart,,"[334.0, 191.0, 1100.0, 572.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,3,figure_title,Figure 1. UV–VIS spectroscopy (A) and TEM images (B) of the GNP solution were obtained.,"[327.0, 590.0, 1065.0, 614.0]",figure_caption,0.92,"[""figure_title label: Figure 1. UV\u2013VIS spectroscopy (A) and TEM images (B) of the ""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
5,4,paragraph_title,3.2. Analysis of the Wound Contraction Rate,"[328.0, 629.0, 703.0, 654.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.2. Analysis of the Wound Contraction Rate""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
5,5,text,"We evaluated the wound contraction rate in %, represented by the reduction in the surface area (Figure 2), where all treated groups showed a significant difference compared to the control group.","[326.0, 660.0, 1122.0, 737.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,6,chart,,"[186.0, 756.0, 1015.0, 1034.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,7,figure_title,"Figure 2. Effects of treatment with MC, GNPs, and hyaluronic acid on wound contraction. The data are presented in mean ± EPM, in which **p < 0.01 vs. excisional wound group (EW) and ***p < 0.001 vs. e","[326.0, 1056.0, 1121.0, 1133.0]",figure_caption,0.92,"[""figure_title label: Figure 2. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
5,8,paragraph_title,3.3. Histological Analysis,"[328.0, 1148.0, 546.0, 1172.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.3. Histological Analysis""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
5,9,text,"In Figures 3 and 4, representative images of the histological sections of the integumentary system can be seen. A decrease in the mean number of inflammatory infiltrates was found in the EW + MC group","[326.0, 1180.0, 1124.0, 1303.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,10,text,"Despite analyzing the percentage of collagen area (Figure 4B), no significant difference was observed between the groups.","[326.0, 1304.0, 1123.0, 1354.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,0,header,"Antioxidants 2022, 11, 2257","[66.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
6,1,number,6 of 15,"[1069.0, 111.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
6,2,figure_title,A),"[334.0, 189.0, 365.0, 221.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
6,3,image,,"[368.0, 200.0, 1078.0, 365.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,4,vision_footnote,"■ Excisional Wound (EW)
■ EW + MC
■ EW + MC + HA
■ EW + MC + GNPs
■ EW + MC + HA + GNPs","[569.0, 383.0, 885.0, 545.0]",footnote,0.7,"[""vision_footnote label: \u25a0 Excisional Wound (EW)\n\u25a0 EW + MC\n\u25a0 EW + MC + HA\n\u25a0 EW + MC +""]",footnote,0.7,body_zone,unknown_like,none,True,True
6,5,figure_title,B),"[333.0, 546.0, 364.0, 577.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
6,6,figure_title,C),"[705.0, 547.0, 735.0, 577.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
6,7,chart,,"[337.0, 550.0, 701.0, 799.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,8,chart,,"[717.0, 552.0, 1055.0, 797.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,9,figure_title,"Figure 3. (A) Representative images of the histological sections of the integumentary system. (B,C) Effects of treatment with MC, GNPs, and hyaluronic acid on the number of inflammatory infiltrates (B","[326.0, 813.0, 1125.0, 917.0]",figure_caption,0.92,"[""figure_title label: Figure 3. (A) Representative images of the histological sect""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
6,10,figure_title,A),"[332.0, 930.0, 363.0, 958.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
6,11,image,,"[353.0, 939.0, 1098.0, 1110.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,12,figure_title,B),"[333.0, 1122.0, 365.0, 1154.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B)""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
6,13,chart,,"[338.0, 1125.0, 1107.0, 1422.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,14,figure_title,"Figure 4. (A) Representative images of the histological sections of the integumentary system. (B) Effects of treatment with MC, GNPs, and hyaluronic acid on the % of collagen area. The data are presen","[326.0, 1439.0, 1125.0, 1515.0]",figure_caption,0.92,"[""figure_title label: Figure 4. (A) Representative images of the histological sect""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
7,0,header,"Antioxidants 2022, 11, 2257","[66.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
7,1,number,7 of 15,"[1068.0, 110.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
7,2,paragraph_title,3.4. Evaluation of Pro-Inflammatory Cytokines,"[327.0, 192.0, 717.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.4. Evaluation of Pro-Inflammatory Cytokines""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
7,3,text,"Figure 5 shows the protein levels of pro-inflammatory cytokines. In Figure 5A, INFγ levels decreased in the EW + MC + HA group (p < 0.05) and in the combined therapy group (p < 0.01) when compared to ","[325.0, 224.0, 1126.0, 400.0]",body_paragraph,0.9,"[""figure caption candidate (body narrative): Figure 5 shows the protein levels of pro-inflammatory cytoki""]",figure_caption_candidate,0.9,display_zone,legend_like,figure_number,True,True
7,4,figure_title,A,"[334.0, 417.0, 356.0, 439.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
7,5,chart,,"[339.0, 418.0, 666.0, 627.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,6,figure_title,B,"[677.0, 417.0, 696.0, 438.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
7,7,chart,,"[680.0, 422.0, 1013.0, 625.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,8,chart,,"[601.0, 638.0, 810.0, 755.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,9,figure_title,C,"[333.0, 766.0, 353.0, 787.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
7,10,figure_title,D,"[676.0, 766.0, 697.0, 787.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
7,11,chart,,"[339.0, 782.0, 663.0, 983.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,12,chart,,"[693.0, 784.0, 1011.0, 982.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
7,13,figure_title,"Figure 5. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of pro-inflammatory cytokines: (A) INF-Y, (B) TNF-α, (C) IL1-β, (D) IL6. The data are presented in mean ± EPM, i","[325.0, 995.0, 1124.0, 1123.0]",figure_caption,0.92,"[""figure_title label: Figure 5. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
7,14,paragraph_title,3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Factors,"[327.0, 1138.0, 892.0, 1163.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Fa""]",subsection_heading,0.85,body_zone,body_like,heading_numbered,True,True
7,15,text,The protein levels of anti-inflammatory cytokines are shown in Figure 6. The levels of IL-4 (Figure 6A) and IL10 (Figure 6B) were increased in the EW + MC + HA and EW + MC + HA + GNPs groups in relati,"[326.0, 1171.0, 1124.0, 1244.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,16,text,The group treated with only the microcurrent (EW + MC) and the group in which the therapies were combined (EW + MC + HA + GNPs) showed a significant increase in the levels of TGF- $ \beta $ (Figure 6C,"[326.0, 1245.0, 1124.0, 1370.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,17,paragraph_title,3.6. Intracellular Determination of Oxidants,"[328.0, 1389.0, 699.0, 1414.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.6. Intracellular Determination of Oxidants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
7,18,text,It can be seen that only the group treated with the combined therapies (EW + MC + HA + GNPs) had their oxidant levels of DCFH (Figure 7A) and nitrite (Figure 7B) decreased when compared to the control,"[326.0, 1419.0, 1124.0, 1497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
8,0,header,"Antioxidants 2022, 11, 2257","[66.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
8,1,number,8 of 15,"[1068.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
8,2,figure_title,A,"[335.0, 191.0, 357.0, 215.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
8,3,chart,,"[338.0, 194.0, 659.0, 399.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,4,figure_title,B,"[677.0, 191.0, 697.0, 214.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
8,5,chart,,"[682.0, 202.0, 1004.0, 398.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,6,chart,,"[591.0, 410.0, 801.0, 529.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,7,figure_title,C,"[332.0, 536.0, 353.0, 558.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
8,8,chart,,"[337.0, 546.0, 660.0, 744.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,9,figure_title,D,"[677.0, 537.0, 698.0, 558.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
8,10,chart,,"[682.0, 550.0, 1003.0, 743.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,11,figure_title,"Figure 6. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of anti-inflammatory cytokines: (A) IL4; (B) IL10; (C) TGF- $ \beta $; (D) FGF. The data are presented in mean ","[326.0, 755.0, 1125.0, 859.0]",figure_caption,0.92,"[""figure_title label: Figure 6. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
8,12,figure_title,A,"[333.0, 876.0, 356.0, 902.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
8,13,chart,,"[335.0, 888.0, 768.0, 1146.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,14,chart,,"[789.0, 941.0, 1016.0, 1220.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,15,figure_title,B,"[333.0, 1167.0, 355.0, 1191.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
8,16,chart,,"[354.0, 1179.0, 763.0, 1430.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
8,17,figure_title,"Figure 7. Effects of treatment with MC, GNPs, and hyaluronic acid on the levels of oxidants: (A) DCF; (B) nitrate. The data are presented in mean ± EPM, in which *p < 0.05 vs. excisional wound group (","[326.0, 1444.0, 1124.0, 1521.0]",figure_caption,0.92,"[""figure_title label: Figure 7. Effects of treatment with MC, GNPs, and hyaluronic""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
9,0,header,"Antioxidants 2022, 11, 2257","[66.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
9,1,number,9 of 15,"[1068.0, 110.0, 1121.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
9,2,paragraph_title,3.7. Markers of Oxidative Damage and Antioxidants,"[327.0, 191.0, 764.0, 217.0]",subsection_heading,0.85,"[""paragraph_title label with numbering: 3.7. Markers of Oxidative Damage and Antioxidants""]",subsection_heading,0.85,body_zone,heading_like,heading_numbered,True,True
9,3,text,"Carbonyl levels had a significant decrease in the EW + MC + HA + GNI's group compared to the EW group (Figure 8A). When the sulfhydryl content was evaluated (Figure 8B), we observed that the EW + MC +","[325.0, 223.0, 1124.0, 351.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,4,figure_title,A,"[333.0, 373.0, 357.0, 398.0]",figure_inner_text,0.9,"[""panel label / figure inner text: A""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
9,5,chart,,"[337.0, 381.0, 697.0, 606.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,6,figure_title,B,"[724.0, 373.0, 747.0, 396.0]",figure_inner_text,0.9,"[""panel label / figure inner text: B""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
9,7,chart,,"[728.0, 385.0, 1097.0, 605.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,8,chart,,"[622.0, 623.0, 857.0, 749.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,9,figure_title,C,"[345.0, 766.0, 367.0, 791.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
9,10,chart,,"[347.0, 769.0, 699.0, 992.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,11,figure_title,D,"[720.0, 766.0, 743.0, 790.0]",figure_inner_text,0.9,"[""panel label / figure inner text: D""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
9,12,chart,,"[725.0, 773.0, 1098.0, 991.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,13,figure_title,"Figure 8. Effects of treatment with MIC, GNPs, and hyaluronic acid on the levels of oxidative damage markers and antioxidants: (A) carbonyl; (B) sulfhydryl; (C) SOD; (D) GSH. The data are presented in","[326.0, 1005.0, 1123.0, 1134.0]",figure_caption,0.92,"[""figure_title label: Figure 8. Effects of treatment with MIC, GNPs, and hyaluroni""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
9,14,text,Antioxidant defense was measured through reduced glutathione and superoxide dismutase levels. SOD levels (Figure 8C) showed a significant decrease in the combined therapy group (EW + MC + HA + GNPs). ,"[324.0, 1152.0, 1123.0, 1255.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,15,paragraph_title,4. Discussion,"[328.0, 1273.0, 458.0, 1296.0]",section_heading,0.85,"[""paragraph_title label with numbering: 4. Discussion""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
9,16,text,"Wounds are a big problem in terms of social impact, and despite the wide range of therapies that can promote the repair of epithelial lesions, the incidence of wounds is progressively increasing, sinc","[324.0, 1304.0, 1123.0, 1505.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
9,17,text,"Clinical studies have reported positive wound healing results using electrical stimulation, and for a while, it has been utilized in clinical practice to speed up wound heal-","[326.0, 1506.0, 1127.0, 1556.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
10,1,header,10 of 15,"[1062.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
10,2,text,"ing [37,38]. An MC is a specific type of microampere ( $ \mu $A) electrical stimulation that replicates currents generated in the body at the cellular level, and it is known to boost cell physiology a","[324.0, 192.0, 1125.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,3,text,"In line with what has been exposed, in the present study, a reduction in the levels of pro-inflammatory cytokines (IFN $ \gamma $, TNF $ \alpha $, IL-1 $ \beta $, and IL6) and inflammatory infiltrates","[325.0, 444.0, 1124.0, 568.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,4,text,"Individually, each therapy promotes some mechanisms of action in the tissue, and, when combined, they can potentiate their isolated effects. MCs allow the transport of bioactive molecules when combine","[325.0, 569.0, 1126.0, 870.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,5,text,"Likewise, the use of GNPs can act as an anti-inflammatory agent in the treatment of various models of tissue injury [49] by blocking the activation of nuclear factor kappa β (NF-κB) and combining with","[323.0, 870.0, 1124.0, 1196.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,6,text,"Only in the group receiving combination treatment was it possible to see an increase in anti-inflammatory cytokines and growth factors, together with a decline in pro-inflammatory cytokines. According","[325.0, 1197.0, 1126.0, 1550.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,0,header,"Antioxidants 2022, 11, 2257","[67.0, 110.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,tail_nonref_hold_zone,unknown_like,none,False,False
11,1,header,11 of 15,"[1062.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
11,2,text,"The effects attributed to HA describe the modulation of pathways that include the suppression of pro-inflammatory cytokines and chemokines [57], in addition to improving membrane stability and favorin","[325.0, 192.0, 1124.0, 443.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
11,3,text,"By reducing the formation of reactive oxygen and nitrogen species, reducing oxidative damage, and stimulating the antioxidant system, the group that was subjected to the combination of the suggested t","[325.0, 444.0, 1125.0, 644.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,4,text,"The capacity of HA to bind to the CD44 receptor, activate pathways involved in the control of cellular redox status, produce intracellular ROS, and chelate $ Fe^{2+} $ and $ Cu^{2+} $ ions—which are","[326.0, 644.0, 1124.0, 795.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
11,5,text,"Likewise, as an antioxidant agent, GNPs exhibit high catalytic activity for free radical scavenging reactions, affecting the thiol bonds of keap1, causing a conformational change that allows the relea","[325.0, 795.0, 1124.0, 970.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
11,6,text,"Since excessive levels of ROS in a wound pose a barrier to the healing process, our results show the potential of combined treatments (MC + HA + GNPs) to restore tissue redox homeostasis and to create","[326.0, 971.0, 1123.0, 1045.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
11,7,text,"Our findings demonstrate that the groups who received MC in conjunction with the topical application of compounds had a reduction in the inflammatory infiltrate when compared to the lesion group, whic","[325.0, 1046.0, 1124.0, 1246.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
11,8,text,"In line with that previously discussed, when evaluating the wound contraction rate in %, this study shows that all therapeutic approaches can promote the healing process by causing the wound to shrink","[326.0, 1247.0, 1124.0, 1422.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,body_like,none,True,True
11,9,text,"Taken together, these results are in agreement with those found in the study conducted by Mendes et al. (2020), where the benefits of using HA in combination with GNPs were also demonstrated and where","[325.0, 1422.0, 1125.0, 1525.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
12,0,header,"Antioxidants 2022, 11, 2257","[67.0, 111.0, 259.0, 132.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
12,1,number,12 of 15,"[1062.0, 111.0, 1121.0, 132.0]",noise,0.9,"[""page number label""]",noise,0.9,,reference_like,reference_numeric_dot,False,False
12,2,paragraph_title,5. Conclusions,"[328.0, 192.0, 471.0, 216.0]",section_heading,0.85,"[""paragraph_title label with numbering: 5. Conclusions""]",section_heading,0.85,body_zone,heading_like,heading_numbered,True,True
12,3,text,"The proposed therapies, when combined, seem to enhance their mechanisms of action, with promising effects in the control of the acute inflammatory response, accelerating the transition to the prolifer","[325.0, 224.0, 1123.0, 298.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
12,4,text,"As a proposal for further studies, it is believed that, with longer analysis periods (between 14 and 21 days), the response of the combined therapy group (EW + MC + HA + GNPs) would have greater reper","[325.0, 299.0, 1124.0, 377.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
12,5,text,"Author Contributions: C.M.—Conceptualization, Data acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing—original draft, Writing—r","[325.0, 398.0, 1125.0, 633.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,support_like,none,True,True
12,6,text,"Funding: This research was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant number [Call CNPq 06/2019—Research Productivity Scholarships], Fundação de Amparo à Pesq","[326.0, 643.0, 1125.0, 762.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
12,7,text,Institutional Review Board Statement: The animal study protocol was approved by the University Ethics Committee (Universidade do Extremo Sul Catarinense—UNESC) with protocol number 16/2020.,"[325.0, 772.0, 1124.0, 820.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
12,8,text,Informed Consent Statement: Not applicable.,"[328.0, 832.0, 704.0, 854.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
12,9,text,Data Availability Statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.,"[327.0, 867.0, 1122.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
12,10,text,Conflicts of Interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.,"[326.0, 926.0, 1122.0, 973.0]",frontmatter_noise,0.88,"[""default body_paragraph for text label"", ""late role resolution: editorial phrase cross-validates non-body classification"", ""zone=body_zone"", ""style_family=support_like""]",body_paragraph,0.6,body_zone,support_like,none,False,False
12,11,paragraph_title,References,"[67.0, 992.0, 175.0, 1015.0]",reference_heading,0.9,"[""references heading: References""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True
12,12,reference_content,"1. Martinengo, L.; Olsson, M.; Bajpai, R.; Soljak, M.; Upton, Z.; Schmidtchen, A.; Car, J.; Järbrink, K. Prevalence of chronic wounds in the general population: Systematic review and meta-analysis of ","[65.0, 1022.0, 1122.0, 1089.0]",reference_item,0.85,"[""reference content label: 1. Martinengo, L.; Olsson, M.; Bajpai, R.; Soljak, M.; Upton""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,13,reference_content,"2. Nussbaum, S.R.; Carter, M.J.; Fife, C.E.; DaVanzo, J.; Haught, R.; Nusgart, M.; Cartwright, D. An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wou","[66.0, 1092.0, 1122.0, 1159.0]",reference_item,0.85,"[""reference content label: 2. Nussbaum, S.R.; Carter, M.J.; Fife, C.E.; DaVanzo, J.; Ha""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,14,reference_content,"3. Holzer-Geissler, J.C.J.; Schwingenschuh, S.; Zacharias, M.; Einsiedler, J.; Kainz, S.; Reisenegger, P.; Holecek, C.; Hofmann, E.; Wolff-Winiski, B.; Fahrngruber, H.; et al. The Impact of Prolonged ","[66.0, 1162.0, 1123.0, 1228.0]",reference_item,0.85,"[""reference content label: 3. Holzer-Geissler, J.C.J.; Schwingenschuh, S.; Zacharias, M""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,15,reference_content,"4. Rajendran, S.B.; Challen, K.; Wright, K.L.; Hardy, J.G. Electrical Stimulation to Enhance Wound Healing. J. Funct. Biomater. 2021, 12, 40. [CrossRef]","[68.0, 1231.0, 1122.0, 1275.0]",reference_item,0.85,"[""reference content label: 4. Rajendran, S.B.; Challen, K.; Wright, K.L.; Hardy, J.G. E""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,16,reference_content,"5. Sahana, T.G.; Rekha, P.D. Biopolymers: Applications in wound healing and skin tissue engineering. Mol. Biol. Rep. 2018, 45, 2857–2867. [CrossRef]","[67.0, 1277.0, 1122.0, 1320.0]",reference_item,0.85,"[""reference content label: 5. Sahana, T.G.; Rekha, P.D. Biopolymers: Applications in wo""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,17,reference_content,"6. Veith, A.P.; Henderson, K.; Spencer, A.; Sligar, A.D.; Baker, A.B. Therapeutic strategies for enhancing angiogenesis in wound healing. Adv. Drug Deliv. Rev. 2019, 146, 97–125. [CrossRef]","[67.0, 1323.0, 1120.0, 1367.0]",reference_item,0.85,"[""reference content label: 6. Veith, A.P.; Henderson, K.; Spencer, A.; Sligar, A.D.; Ba""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,18,reference_content,"7. Zaccaron, R.P.; Barbieri, R.T.; Mendes, C.; Venturini, L.M.; Alves, N.; Mariano, S.S.; de Andrade, T.A.M.; Hermes de Araújo, P.H.; Feuser, P.E.; Thirupathi, A.; et al. Photobiomodulation associated","[66.0, 1369.0, 1121.0, 1436.0]",reference_item,0.85,"[""reference content label: 7. Zaccaron, R.P.; Barbieri, R.T.; Mendes, C.; Venturini, L.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,19,reference_content,"8. Foulds, I.S.; Barker, A.T. Human skin battery potentials and their possible role in wound healing. Br. J. Dermatol. 1983, 109, 515–522. [CrossRef]","[66.0, 1438.0, 1122.0, 1481.0]",reference_item,0.85,"[""reference content label: 8. Foulds, I.S.; Barker, A.T. Human skin battery potentials ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
12,20,reference_content,"9. Nair, H.K.R. Microcurrent as an adjunct therapy to accelerate chronic wound healing and reduce patient pain. J. Wound Care 2018, 27, 296–306. [CrossRef]","[66.0, 1484.0, 1123.0, 1527.0]",reference_item,0.85,"[""reference content label: 9. Nair, H.K.R. Microcurrent as an adjunct therapy to accele""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,0,header,"Antioxidants 2022, 11, 2257","[66.0, 111.0, 259.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
13,1,number,13 of 15,"[1061.0, 111.0, 1122.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False
13,2,reference_content,"10. Poltawski, L.; Watson, T. Bioelectricity and microcurrent therapy for tissue healing—A narrative review. Phys. Ther. Rev. 2009, 14, 104–114. [CrossRef]","[66.0, 193.0, 1122.0, 237.0]",reference_item,0.85,"[""reference content label: 10. Poltawski, L.; Watson, T. Bioelectricity and microcurren""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,3,reference_content,"11. Vieira, A.C.; Reid, B.; Cao, L.; Mannis, M.J.; Schwab, I.R.; Zhao, M. Ionic components of electric current at rat corneal wounds. PLoS ONE 2011, 6, e17411. [CrossRef] [PubMed]","[67.0, 240.0, 1122.0, 284.0]",reference_item,0.85,"[""reference content label: 11. Vieira, A.C.; Reid, B.; Cao, L.; Mannis, M.J.; Schwab, I""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,4,reference_content,"12. Jennings, J.; Chen, D.; Feldman, D. Transcriptional response of dermal fibroblasts in direct current electric fields. Bioelectromagnetics 2008, 29, 394–405. [CrossRef] [PubMed]","[67.0, 285.0, 1122.0, 329.0]",reference_item,0.85,"[""reference content label: 12. Jennings, J.; Chen, D.; Feldman, D. Transcriptional resp""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,5,reference_content,"13. Alvarez, O.M.; Mertz, P.M.; Smerbeck, R.V.; Eaglstein, W.H. The healing of superficial skin wounds is stimulated by external electrical current. J. Investig. Dermatol. 1983, 81, 144–148. [CrossRef","[67.0, 332.0, 1119.0, 376.0]",reference_item,0.85,"[""reference content label: 13. Alvarez, O.M.; Mertz, P.M.; Smerbeck, R.V.; Eaglstein, W""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,6,reference_content,"14. Zhao, M.; Bai, H.; Wang, E.; Forrester, J.V.; McCaig, C.D. Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. J. Ce","[68.0, 378.0, 1121.0, 421.0]",reference_item,0.85,"[""reference content label: 14. Zhao, M.; Bai, H.; Wang, E.; Forrester, J.V.; McCaig, C.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,7,reference_content,"15. Park, R.J.; Son, H.; Kim, K.; Kim, S.; Oh, T. The Effect of Microcurrent Electrical Stimulation on the Foot Blood Circulation and Pain of Diabetic Neuropathy. J. Phys. Ther. Sci. 2011, 23, 515–518","[69.0, 424.0, 1122.0, 468.0]",reference_item,0.85,"[""reference content label: 15. Park, R.J.; Son, H.; Kim, K.; Kim, S.; Oh, T. The Effect""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,8,reference_content,"16. Clarke Moloney, M.; Lyons, G.M.; Breen, P.; Burke, P.E.; Grace, P.A. Haemodynamic study examining the response of venous blood flow to electrical stimulation of the gastrocnemius muscle in patient","[68.0, 470.0, 1122.0, 537.0]",reference_item,0.85,"[""reference content label: 16. Clarke Moloney, M.; Lyons, G.M.; Breen, P.; Burke, P.E.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,9,reference_content,"17. Sharifi, S.; Hajipour, M.J.; Gould, L.; Mahmoudi, M. Nanomedicine in Healing Chronic Wounds: Opportunities and Challenges. Mol. Pharm. 2021, 18, 550–575. [CrossRef]","[68.0, 539.0, 1124.0, 582.0]",reference_item,0.85,"[""reference content label: 17. Sharifi, S.; Hajipour, M.J.; Gould, L.; Mahmoudi, M. Nan""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,10,reference_content,"18. Mahmoudi, A.; Kesharwani, P.; Majeed, M.; Teng, Y.; Sahebkar, A. Recent advances in nanogold as a promising nanocarrier for curcumin delivery. Colloids Surfaces. B Biointerfaces 2022, 215, 112481.","[68.0, 585.0, 1123.0, 629.0]",reference_item,0.85,"[""reference content label: 18. Mahmoudi, A.; Kesharwani, P.; Majeed, M.; Teng, Y.; Sahe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,11,reference_content,"19. da Rocha, F.R.; Haupenthal, D.P.d.S.; Zaccaron, R.P.; Corrêa, M.E.A.B.; Tramontin, N.d.S.; Fonseca, J.P.; Nesi, R.T.; Muller, A.P.; Pinho, R.A.; Paula, M.M.d.S.; et al. Therapeutic effects of iont","[67.0, 631.0, 1123.0, 697.0]",reference_item,0.85,"[""reference content label: 19. da Rocha, F.R.; Haupenthal, D.P.d.S.; Zaccaron, R.P.; Co""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,12,reference_content,"20. Akturk, O.; Kismet, K.; Yasti, A.C.; Kuru, S.; Duymus, M.E.; Kaya, F.; Caydere, M.; Hucumenoglu, S.; Keskin, D. Collagen/gold nanoparticle nanocomposites: A potential skin wound healing biomateria","[66.0, 700.0, 1122.0, 745.0]",reference_item,0.85,"[""reference content label: 20. Akturk, O.; Kismet, K.; Yasti, A.C.; Kuru, S.; Duymus, M""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,13,reference_content,"21. Mendes, C.; dos Santos Haupenthal, D.P.; Zaccaron, R.P.; de Bem Silveira, G.; Corrêa, M.E.A.B.; de Roch Casagrande, L.; de Sousa Mariano, S.; de Souza Silva, J.I.; de Andrade, T.A.M.; Feuser, P.E.","[67.0, 747.0, 1120.0, 814.0]",reference_item,0.85,"[""reference content label: 21. Mendes, C.; dos Santos Haupenthal, D.P.; Zaccaron, R.P.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,14,reference_content,"22. Kim, Y.; Lee, Y.-S.; Choe, J.; Lee, H.; Kim, Y.-M.; Jeoung, D. CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C sign","[67.0, 815.0, 1122.0, 881.0]",reference_item,0.85,"[""reference content label: 22. Kim, Y.; Lee, Y.-S.; Choe, J.; Lee, H.; Kim, Y.-M.; Jeou""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,15,reference_content,"23. Xu, Z.; Liu, G.; Liu, P.; Hu, Y.; Chen, Y.; Fang, Y.; Sun, G.; Huang, H.; Wu, J. Hyaluronic acid-based glucose-responsive antioxidant hydrogel platform for enhanced diabetic wound repair. Acta Bio","[66.0, 884.0, 1122.0, 928.0]",reference_item,0.85,"[""reference content label: 23. Xu, Z.; Liu, G.; Liu, P.; Hu, Y.; Chen, Y.; Fang, Y.; Su""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,16,reference_content,"24. Corrêa, M.; Mendes, C.; Bittencourt, J.V.S.; Takejima, A.; de Souza, I.C.; de Carvalho, S.C.D.; Orlandini, I.G.; de Andrade, T.A.M.; Guarita-Souza, L.C.; Silveira, P.C.L. Effects of the Applicatio","[66.0, 931.0, 1123.0, 997.0]",reference_item,0.85,"[""reference content label: 24. Corr\u00eaa, M.; Mendes, C.; Bittencourt, J.V.S.; Takejima, A""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,17,reference_content,"25. Wu, S.; Zhao, W.; Sun, M.; He, P.; Lv, H.; Wang, Q.; Ma, J. Novel bi-layered dressing patches constructed with radially-oriented nanofibrous pattern and herbal compound-loaded hydrogel for acceler","[67.0, 999.0, 1122.0, 1065.0]",reference_item,0.85,"[""reference content label: 25. Wu, S.; Zhao, W.; Sun, M.; He, P.; Lv, H.; Wang, Q.; Ma,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,18,reference_content,"26. Wu, S.; Dong, T.; Li, Y.; Sun, M.; Qi, Y.; Liu, J.; Duan, B. State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applications. Appl. Mater. Today 2022, 27,","[66.0, 1068.0, 1122.0, 1112.0]",reference_item,0.85,"[""reference content label: 26. Wu, S.; Dong, T.; Li, Y.; Sun, M.; Qi, Y.; Liu, J.; Duan""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,19,reference_content,"27. Yu, R.; Zhang, H.; Guo, B. Conductive biomaterials as bioactive wound dressing for wound healing and skin tissue engineering. Nano-Micro Lett. 2022, 14, 1–46. [CrossRef]","[67.0, 1115.0, 1124.0, 1158.0]",reference_item,0.85,"[""reference content label: 27. Yu, R.; Zhang, H.; Guo, B. Conductive biomaterials as bi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,20,reference_content,"28. Li, T.; Sun, M.; Wu, S. State-of-the-art review of electrospun gelatin-based nanofiber dressings for wound healing applications. Nanomaterials 2022, 12, 784. [CrossRef] [PubMed]","[67.0, 1160.0, 1123.0, 1204.0]",reference_item,0.85,"[""reference content label: 28. Li, T.; Sun, M.; Wu, S. State-of-the-art review of elect""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,21,reference_content,"29. Della Vechia, I.C.; Steiner, B.T.; Freitas, M.L.; Fidelis, G.d.S.P.; Galvani, N.C.; Ronchi, J.M.; Possato, J.C.; Fagundes, M.I.; Rigo, F.K.; Feuser, P.E.; et al. Comparative cytotoxic effect of ci","[67.0, 1206.0, 1123.0, 1272.0]",reference_item,0.85,"[""reference content label: 29. Della Vechia, I.C.; Steiner, B.T.; Freitas, M.L.; Fideli""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,22,reference_content,"30. Andrade, T.A.M.; Masson-Meyers, D.S.; Caetano, G.F.; Terra, V.A.; Ovidio, P.P.; Jordão-Júnior, A.A.; Frade, M.A.C. Skin changes in streptozotocin-induced diabetic rats. Biochem. Biophys. Res. Comm","[67.0, 1275.0, 1120.0, 1319.0]",reference_item,0.85,"[""reference content label: 30. Andrade, T.A.M.; Masson-Meyers, D.S.; Caetano, G.F.; Ter""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,23,reference_content,"31. Jiang, X.; Ge, H.; Zhou, C.; Chai, X.; Deng, H. The role of transforming growth factor $ \beta1 $ in fractional laser resurfacing with a carbon dioxide laser. Lasers Med. Sci. 2014, 29, 681–687. ","[68.0, 1321.0, 1121.0, 1365.0]",reference_item,0.85,"[""reference content label: 31. Jiang, X.; Ge, H.; Zhou, C.; Chai, X.; Deng, H. The role""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,24,reference_content,"32. Vidal, B.C.; Mello, M.L.S. Supramolecular order following binding of the dichroic birefringent sulfonic dye Ponceau SS to collagen fibers. Biopolymers 2005, 78, 121–128. [CrossRef] [PubMed]","[67.0, 1368.0, 1122.0, 1412.0]",reference_item,0.85,"[""reference content label: 32. Vidal, B.C.; Mello, M.L.S. Supramolecular order followin""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
13,25,reference_content,"33. Curtolo, G.; de Paula Araújo, J.; Lima, J.A.; Brandt, J.V.; Bittencourt, J.V.S.; Venturini, L.M.; Silveira, P.C.L.; Rogers, S.; Franzini, C.M.; de Goes, V.F. Silver nanoparticles formulations for ","[67.0, 1414.0, 1124.0, 1480.0]",reference_item,0.85,"[""reference content label: 33. Curtolo, G.; de Paula Ara\u00fajo, J.; Lima, J.A.; Brandt, J.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,0,header,"Antioxidants 2022, 11, 2257","[66.0, 111.0, 259.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
14,1,number,14 of 15,"[1061.0, 111.0, 1122.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False
14,2,reference_content,"34. Corrêa, M.E.A.B.; dos Santos Haupenthal, D.P.; Mendes, C.; Zaccaron, R.P.; de Roch Casagrande, L.; Venturini, L.M.; Porto, G.D.; Bittencourt, J.V.S.; de Souza Silva, J.I.; de Sousa Mariano, S.; et","[66.0, 193.0, 1122.0, 283.0]",reference_item,0.85,"[""reference content label: 34. Corr\u00eaa, M.E.A.B.; dos Santos Haupenthal, D.P.; Mendes, C""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,3,reference_content,"35. Bannister, J.V.; Calabrese, L. Assays for superoxide dismutase. Methods Biochem. Anal. 1987, 32, 279–312.","[66.0, 285.0, 936.0, 307.0]",reference_item,0.85,"[""reference content label: 35. Bannister, J.V.; Calabrese, L. Assays for superoxide dis""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
14,4,reference_content,"36. Dos Santos Haupenthal, D.P.; Mendes, C.; de Bem Silveira, G.; Zaccaron, R.P.; Correa, M.; Nesi, R.T.; Pinho, R.A.; da Silva Paula, M.M.; Silveira, P.C.L. Effects of treatment with gold nanoparticl","[67.0, 309.0, 1123.0, 376.0]",reference_item,0.85,"[""reference content label: 36. Dos Santos Haupenthal, D.P.; Mendes, C.; de Bem Silveira""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,5,reference_content,"37. Franek, A.; Kostur, R.; Polak, A.; Taradaj, J.; Szlachta, Z.; Blaszczak, E.; Dolibog, P.; Dolibog, P.; Koczy, B.; Kucio, C. Using high-voltage electrical stimulation in the treatment of recalcitra","[67.0, 378.0, 1122.0, 444.0]",reference_item,0.85,"[""reference content label: 37. Franek, A.; Kostur, R.; Polak, A.; Taradaj, J.; Szlachta""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
14,6,reference_content,"38. Polak, A.; Franek, A.; Taradaj, J. High-Voltage Pulsed Current Electrical Stimulation in Wound Treatment. Adv. Wound Care 2014, 3, 104–117. [CrossRef]","[67.0, 447.0, 1123.0, 490.0]",reference_item,0.85,"[""reference content label: 38. Polak, A.; Franek, A.; Taradaj, J. High-Voltage Pulsed C""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,7,reference_content,"39. Ahmed, A.F.; Elgayed, S.S.A.; Ibrahim, I.M. Polarity effect of microcurrent electrical stimulation on tendon healing: Biomechanical and histopathological studies. J. Adv. Res. 2012, 3, 109–117. [C","[67.0, 493.0, 1124.0, 537.0]",reference_item,0.85,"[""reference content label: 39. Ahmed, A.F.; Elgayed, S.S.A.; Ibrahim, I.M. Polarity eff""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,8,reference_content,"40. Kaur, U.; Banerjee, P.; Bir, A.; Sinha, M.; Biswas, A.; Chakrabarti, S. Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: The NF-kappaB connection. Curr. Top. ","[68.0, 539.0, 1124.0, 584.0]",reference_item,0.85,"[""reference content label: 40. Kaur, U.; Banerjee, P.; Bir, A.; Sinha, M.; Biswas, A.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,9,reference_content,"41. Yu, C.; Hu, Z.-Q.; Peng, R.-Y.J.M.M.R. Effects and mechanisms of a microcurrent dressing on skin wound healing: A review. Mil. Med. Res. 2014, 1, 24. [CrossRef] [PubMed]","[68.0, 585.0, 1123.0, 628.0]",reference_item,0.85,"[""reference content label: 41. Yu, C.; Hu, Z.-Q.; Peng, R.-Y.J.M.M.R. Effects and mecha""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,10,reference_content,"42. Sugimoto, M.; Maeshige, N.; Honda, H.; Yoshikawa, Y.; Uemura, M.; Yamamoto, M.; Terashi, H. Optimum microcurrent stimulation intensity for galvanotaxis in human fibroblasts. J. Wound Care 2012, 21","[67.0, 631.0, 1123.0, 675.0]",reference_item,0.85,"[""reference content label: 42. Sugimoto, M.; Maeshige, N.; Honda, H.; Yoshikawa, Y.; Ue""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,11,reference_content,"43. Lee, B.Y.; Al-Waili, N.; Stubbs, D.; Wendell, K.; Butler, G.; Al-Waili, T.; Al-Waili, A. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of t","[67.0, 677.0, 1123.0, 743.0]",reference_item,0.85,"[""reference content label: 43. Lee, B.Y.; Al-Waili, N.; Stubbs, D.; Wendell, K.; Butler""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
14,12,reference_content,"44. Wang, Y.; Zeng, L.; Song, W.; Liu, J. Influencing factors and drug application of iontophoresis in transdermal drug delivery: An overview of recent progress. Drug Deliv. Transl. Res. 2021, 12, 15–","[67.0, 746.0, 1123.0, 790.0]",reference_item,0.85,"[""reference content label: 44. Wang, Y.; Zeng, L.; Song, W.; Liu, J. Influencing factor""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,13,reference_content,"45. Petrilli, R.; Lopez, R.F.V. Physical methods for topical skin drug delivery: Concepts and applications. Braz. J. Pharm. Sci. 2018, 54, e01008. [CrossRef]","[67.0, 792.0, 1122.0, 835.0]",reference_item,0.85,"[""reference content label: 45. Petrilli, R.; Lopez, R.F.V. Physical methods for topical""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
14,14,reference_content,"46. Manabe, E.; Numajiri, S.; Sugibayashi, K.; Morimoto, Y. Analysis of skin permeation-enhancing mechanism of iontophoresis using hydrodynamic pore theory. J. Control. Release 2000, 66, 149–158. [Cro","[66.0, 838.0, 1122.0, 883.0]",reference_item,0.85,"[""reference content label: 46. Manabe, E.; Numajiri, S.; Sugibayashi, K.; Morimoto, Y. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,15,reference_content,"47. Arunkumar, S.; Ashok, P.; Desai, B.; Shivakumar, H.N. Technology. Effect of chemical penetration enhancer on transdermal iontophoretic delivery of diclofenac sodium under constant voltage. J. Drug","[66.0, 884.0, 1122.0, 928.0]",reference_item,0.85,"[""reference content label: 47. Arunkumar, S.; Ashok, P.; Desai, B.; Shivakumar, H.N. Te""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,16,reference_content,"48. Kim, J.W.; Shim, J.S.; Maeng, C.; Kim, Y.S.; Ahn, J.; Kwak, M.G.; Hong, S.J.; Cho, H.M. Fabrication of SiC nanoparticles by physical milling for ink-jet printing. J. Nanosci. Nanotechnol. 2013, 13","[66.0, 930.0, 1122.0, 974.0]",reference_item,0.85,"[""reference content label: 48. Kim, J.W.; Shim, J.S.; Maeng, C.; Kim, Y.S.; Ahn, J.; Kw""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,17,reference_content,"49. Dohnert, M.B.; Venancio, M.; Possato, J.C.; Zeferino, R.C.; Dohnert, L.H.; Zugno, A.I.; De Souza, C.T.; Paula, M.M.; Luciano, T.F. Gold nanoparticles and diclofenac diethylammonium administered by","[66.0, 976.0, 1122.0, 1043.0]",reference_item,0.85,"[""reference content label: 49. Dohnert, M.B.; Venancio, M.; Possato, J.C.; Zeferino, R.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,18,reference_content,"50. Jeon, K.I.; Byun, M.S.; Jue, D.M. Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit. Exp. Mol. Med. 2003, 35, 61–66. [CrossRef]","[67.0, 1045.0, 1122.0, 1089.0]",reference_item,0.85,"[""reference content label: 50. Jeon, K.I.; Byun, M.S.; Jue, D.M. Gold compound auranofi""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,19,reference_content,"51. Sumbayev, V.V.; Yasinska, I.M.; Garcia, C.P.; Gilliland, D.; Lall, G.S.; Gibbs, B.F.; Bonsall, D.R.; Varani, L.; Rossi, F.; Calzolai, L. Gold nanoparticles downregulate interleukin-1beta-induced p","[67.0, 1091.0, 1124.0, 1157.0]",reference_item,0.85,"[""reference content label: 51. Sumbayev, V.V.; Yasinska, I.M.; Garcia, C.P.; Gilliland,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,20,reference_content,"52. Boomi, P.; Ganesan, R.; Poorani, G.P.; Jegatheeswaran, S.; Balakumar, C.; Prabu, H.G.; Anand, K.; Prabhu, N.M.; Jeyakanthan, J.; Saravanan, M. Phyto-Engineered Gold Nanoparticles (AuNPs) with Pote","[66.0, 1160.0, 1123.0, 1228.0]",reference_item,0.85,"[""reference content label: 52. Boomi, P.; Ganesan, R.; Poorani, G.P.; Jegatheeswaran, S""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,21,reference_content,"53. Ni, C.; Zhou, J.; Kong, N.; Bian, T.; Zhang, Y.; Huang, X.; Xiao, Y.; Yang, W.; Yan, F. Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontit","[67.0, 1229.0, 1123.0, 1295.0]",reference_item,0.85,"[""reference content label: 53. Ni, C.; Zhou, J.; Kong, N.; Bian, T.; Zhang, Y.; Huang, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,22,reference_content,"54. Nguyen, V.-L.; Truong, C.-T.; Nguyen, B.C.Q.; Vo, T.-N.V.; Dao, T.-T.; Nguyen, V.-D.; Trinh, D.-T.T.; Huynh, H.K.; Bui, C.-B. Anti-inflammatory and wound healing activities of calophyllolide isola","[67.0, 1298.0, 1123.0, 1365.0]",reference_item,0.85,"[""reference content label: 54. Nguyen, V.-L.; Truong, C.-T.; Nguyen, B.C.Q.; Vo, T.-N.V""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,23,reference_content,"55. Singer, A.J.; Clark, R.A. Cutaneous wound healing. N. Engl. J. Med. 1999, 341, 738–746. [CrossRef]","[67.0, 1367.0, 890.0, 1390.0]",reference_item,0.85,"[""reference content label: 55. Singer, A.J.; Clark, R.A. Cutaneous wound healing. N. En""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,24,reference_content,"56. Trengove, N.J.; Stacey, M.C.; MacAuley, S.; Bennett, N.; Gibson, J.; Burslem, F.; Murphy, G.; Schultz, G. Analysis of the acute and chronic wound environments: The role of proteases and their inhi","[66.0, 1391.0, 1121.0, 1435.0]",reference_item,0.85,"[""reference content label: 56. Trengove, N.J.; Stacey, M.C.; MacAuley, S.; Bennett, N.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,25,reference_content,"57. Altman, R.; Bedi, A.; Manjoo, A.; Niazi, F.; Shaw, P.; Mease, P. Anti-inflammatory effects of intra-articular hyaluronic acid: A systematic review. Cartilage 2019, 10, 43–52. [CrossRef]","[67.0, 1437.0, 1123.0, 1480.0]",reference_item,0.85,"[""reference content label: 57. Altman, R.; Bedi, A.; Manjoo, A.; Niazi, F.; Shaw, P.; M""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,26,reference_content,"58. Anderson, I. The properties of hyaluronan and its role in wound healing. Prof. Nurse. 2001, 17, 232–235.","[67.0, 1482.0, 935.0, 1503.0]",reference_item,0.85,"[""reference content label: 58. Anderson, I. The properties of hyaluronan and its role i""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
14,27,reference_content,"59. Zhao, J.Y.; Chai, J.K.; Song, H.F.; Zhang, J.; Xu, M.H.; Liang, Y.-D. Influence of hyaluronic acid on wound healing using composite porcine acellular dermal matrix grafts and autologous skin in ra","[66.0, 1506.0, 1120.0, 1552.0]",reference_item,0.85,"[""reference content label: 59. Zhao, J.Y.; Chai, J.K.; Song, H.F.; Zhang, J.; Xu, M.H.;""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,0,header,"Antioxidants 2022, 11, 2257","[66.0, 112.0, 259.0, 131.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
15,1,number,15 of 15,"[1061.0, 112.0, 1122.0, 131.0]",noise,0.9,"[""page number label""]",noise,0.9,reference_zone,reference_like,reference_numeric_dot,False,False
15,2,reference_content,"60. Senel, O.; Cetinkale, O.; Ozbay, G.; Ahçioğlu, F.; Bulan, R. Oxygen free radicals impair wound healing in ischemic rat skin. Ann. Plast. Surg. 1997, 39, 516–523. [CrossRef]","[66.0, 194.0, 1122.0, 238.0]",reference_item,0.85,"[""reference content label: 60. Senel, O.; Cetinkale, O.; Ozbay, G.; Ah\u00e7io\u011flu, F.; Bulan""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,3,reference_content,"61. Litwiniuk, M.; Krejner, A.; Speyrer, M.S.; Gauto, A.R.; Grzela, T. Hyaluronic acid in inflammation and tissue regeneration. Wounds 2016, 28, 78–88. [PubMed]","[68.0, 241.0, 1121.0, 283.0]",reference_item,0.85,"[""reference content label: 61. Litwiniuk, M.; Krejner, A.; Speyrer, M.S.; Gauto, A.R.; ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,4,reference_content,"62. Trabucchi, E.; Pallotta, S.; Morini, M.; Corsi, F.; Franceschini, R.; Casiraghi, A.; Pravettoni, A.; Foschi, D.; Minghetti, P. Low molecular weight hyaluronic acid prevents oxygen free radical dam","[68.0, 286.0, 1122.0, 352.0]",reference_item,0.85,"[""reference content label: 62. Trabucchi, E.; Pallotta, S.; Morini, M.; Corsi, F.; Fran""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,5,reference_content,"63. Cheng, H.; Lai, G.; Fu, L.; Zhang, H.; Yu, A. Enzymatically catalytic deposition of gold nanoparticles by glucose oxidase-functionalized gold nanoprobe for ultrasensitive electrochemical immunoass","[68.0, 355.0, 1122.0, 421.0]",reference_item,0.85,"[""reference content label: 63. Cheng, H.; Lai, G.; Fu, L.; Zhang, H.; Yu, A. Enzymatica""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,6,reference_content,"64. Ahn, S.; Singh, P.; Castro-Aceituno, V.; Yesmin Simu, S.; Kim, Y.-J.; Mathiyalagan, R.; Yang, D.-C. Gold nanoparticles synthesized using Panax ginseng leaves suppress inflammatory-mediators produc","[67.0, 425.0, 1122.0, 490.0]",reference_item,0.85,"[""reference content label: 64. Ahn, S.; Singh, P.; Castro-Aceituno, V.; Yesmin Simu, S.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,7,reference_content,"65. Pinho, R.A.; Haupenthal, D.P.; Fauser, P.E.; Thirupathi, A.; Silveira, P.C.L. Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress. J. Inflamm. Res. 2022, 15, 3219–3234. [C","[67.0, 493.0, 1122.0, 537.0]",reference_item,0.85,"[""reference content label: 65. Pinho, R.A.; Haupenthal, D.P.; Fauser, P.E.; Thirupathi,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,8,reference_content,"66. Harding, K.G.; Morris, H.L.; Patel, G.K. Science, medicine and the future: Healing chronic wounds. BMJ 2002, 324, 160–163. [CrossRef]","[67.0, 539.0, 1122.0, 582.0]",reference_item,0.85,"[""reference content label: 66. Harding, K.G.; Morris, H.L.; Patel, G.K. Science, medici""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
15,9,reference_content,"67. Tai, G.; Tai, M.; Zhao, M. Electrically stimulated cell migration and its contribution to wound healing. Burn. Trauma 2018, 6. [CrossRef]","[67.0, 586.0, 1124.0, 628.0]",reference_item,0.85,"[""reference content label: 67. Tai, G.; Tai, M.; Zhao, M. Electrically stimulated cell ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 header_image [70.0, 101.0, 139.0, 167.0] non_body_insert 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False False
3 1 1 header antioxidants [146.0, 114.0, 352.0, 155.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone support_like short_fragment False False
4 1 2 header_image [1030.0, 109.0, 1119.0, 168.0] non_body_insert 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False False
5 1 3 text Article [65.0, 208.0, 131.0, 231.0] non_body_insert 0.3 ["short text, uncertain role"] unknown_structural 0.3 frontmatter_main_zone support_like short_fragment False False
6 1 4 doc_title Microcurrent and Gold Nanoparticles Combined with Hyaluronic Acid Accelerates Wound Healing [65.0, 232.0, 959.0, 313.0] paper_title 0.8 ["page-1 zone title_zone: Microcurrent and Gold Nanoparticles Combined with Hyaluronic"] paper_title 0.8 frontmatter_main_zone support_like none True True
7 1 5 text Carolini Mendes 1,2, Anand Thirupathi 1,*⊕, Rubya Pereira Zaccaron 2, Maria Eduardo Anastácio Borges Corrêa 2, João V. S. Bittencourt 2, Laura de Roch Casagrande 2, Anadhelly C. S. de Lima 2, Lara L. [64.0, 334.0, 1108.0, 437.0] authors 0.8 ["page-1 zone author_zone: Carolini Mendes 1,2, Anand Thirupathi 1,*\u2295, Rubya Pereira Za"] authors 0.8 frontmatter_main_zone support_like none True True
8 1 6 text $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningbo 315211, China [326.0, 478.0, 842.0, 501.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{1} $ Faculty of Sports Science, Ningbo University, Ningb"] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
9 1 7 text $ ^{2} $ Laboratory of Experimental Phisiopatology, Program of Postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Cricúima 88806-000, Brazil [326.0, 501.0, 1121.0, 543.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{2} $ Laboratory of Experimental Phisiopatology, Program "] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
10 1 8 text $ ^{3} $ Graduate Program of Biomedical Science, Herminio Ometto Foundation, Araras 13607-339, Brazil [327.0, 544.0, 1051.0, 566.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{3} $ Graduate Program of Biomedical Science, Herminio Om"] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
11 1 9 image [69.0, 733.0, 178.0, 770.0] media_asset 0.85 ["media label: image"] media_asset 0.85 frontmatter_main_zone support_like empty True True
12 1 10 text Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corrêa, M.E.A.B.; Bittencourt, J.V.S.; Casagrande, L.d.R.; de Lima, A.C.S.; de Oliveira, L.L.; de Andrade, T.A.M.; Gu, Y.; et al. Microcurrent and [65.0, 778.0, 308.0, 1037.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Citation: Mendes, C.; Thirupathi, A.; Zaccaron, R.P.; Corr\u00eaa"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
13 1 11 image [69.0, 1313.0, 185.0, 1353.0] media_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
14 1 12 text Academic Editor: Reinhart M. Speeckaert [67.0, 1052.0, 260.0, 1097.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Academic Editor: Reinhart M. Speeckaert"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
15 1 13 text Received: 16 September 2022 Accepted: 7 November 2022 Published: 15 November 2022 [67.0, 1114.0, 259.0, 1183.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Received: 16 September 2022\nAccepted: 7 November 2022\nPublis"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
16 1 14 text Publisher's Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. * Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.) [66.0, 1197.0, 307.0, 1289.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Publisher's Note: MDPI stays neutral\nwith regard to jurisdic"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
17 1 15 text * Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.net (P.C.L.S.) [327.0, 567.0, 885.0, 589.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: * Correspondence: anand@nbu.edu.cn (A.T.); psilveira@unesc.n"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
18 1 16 text Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licen [66.0, 1363.0, 309.0, 1551.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Copyright: \u00a9 2022 by the authors. Licensee MDPI, Basel, Swit"] frontmatter_noise 0.8 body_zone support_like none False False
19 1 17 abstract Abstract: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. Fifty Wistar rats (n = 10 [326.0, 614.0, 1125.0, 1105.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
20 1 18 text Keywords: wound healing; iontophoresis; gold nanoparticles; hyaluronic acid; inflammation [327.0, 1133.0, 1072.0, 1158.0] frontmatter_noise 0.7 ["frontmatter noise text: Keywords: wound healing; iontophoresis; gold nanoparticles; "] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
21 1 19 paragraph_title 1. Introduction [328.0, 1232.0, 473.0, 1255.0] section_heading 0.85 ["paragraph_title label with numbering: 1. Introduction"] section_heading 0.85 body_zone heading_like heading_numbered True True
22 1 20 text Currently, the prevalence of non-healing wounds in developed countries is 1 to 2%, and this rate is significantly increased in underdeveloped countries. However, this problem affects the population in [325.0, 1263.0, 1125.0, 1462.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
23 1 21 text New materials and approaches are urgently desirable for wound healing since current treatments are closely restricted to bed hygiene and dressing changes; although essential, in some situations, these [324.0, 1464.0, 1126.0, 1542.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
24 1 22 footer Antioxidants 2022, 11, 2257. https://doi.org/10.3390/antiox11112257 [66.0, 1625.0, 557.0, 1647.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
25 1 23 footer https://www.mdpi.com/journal/antioxidants [784.0, 1625.0, 1122.0, 1648.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
26 2 0 header Antioxidants 2022, 11, 2257 [67.0, 111.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 frontmatter_side_zone support_like none False False
27 2 1 header 2 of 15 [1068.0, 111.0, 1121.0, 131.0] noise 0.9 ["header label"] noise 0.9 frontmatter_main_zone reference_like reference_numeric_dot False False
28 2 2 text it is important to develop other approaches that accelerate the acute inflammatory and re-epithelialization process, thus avoiding complications and excessive expenditures in the health system [6,7]. [325.0, 192.0, 1123.0, 266.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
29 2 3 text A microcurrent (MC) or a microgalvanic current is an electrical current in the range of microamperes ( $ \mu $A), polarized and continuous, and it promotes a physical stimulus and is non-invasive, non [326.0, 268.0, 1125.0, 468.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
30 2 4 text Furthermore, through electrophoresis and electro-osmosis, MC allows the passage of charged and uncharged biomolecules across biological membranes. Iontophoresis is the collective name for these two pr [326.0, 469.0, 1124.0, 669.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
31 2 5 text Currently, the development of nanomaterials, such as gold nanoparticles (GNPs), represents a promising approach to wound care [17]. Due to their focused delivery, lower toxicity, and higher absorption [326.0, 670.0, 1124.0, 921.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
32 2 6 text Hyaluronic acid (HA) is a component of the extracellular matrix, and it has excellent benefits for the treatment of dermal and epidermal lesions [22]. Its capacity to promote the production of fibrin, [325.0, 920.0, 1124.0, 1274.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
33 2 7 paragraph_title 2. Materials and Methods [328.0, 1291.0, 569.0, 1315.0] section_heading 0.85 ["paragraph_title label with numbering: 2. Materials and Methods"] section_heading 0.85 body_zone heading_like heading_numbered True True
34 2 8 paragraph_title 2.1. Animals [328.0, 1318.0, 443.0, 1342.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.1. Animals"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
35 2 9 text All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (Bethesda, MD, USA) and with t [326.0, 1349.0, 1123.0, 1474.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
36 2 10 text Fifty Wistar male rats (60 days old, weighing between 250 and 300 g) were used, and they were kept at a controlled room temperature between $ 20 \pm 22\ ^{\circ}\mathrm{C} $, under a light-dark [326.0, 1475.0, 1123.0, 1527.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
37 3 0 header Antioxidants 2022, 11, 2257 [67.0, 111.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
38 3 1 number 3 of 15 [1068.0, 111.0, 1121.0, 132.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
39 3 2 text cycle 12/12 h, and with free access to water and food. Male rats were used so that there were no changes in the inflammatory analysis due to hormones. [324.0, 192.0, 1122.0, 242.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
40 3 3 text The animals were randomly assigned to five experimental groups with n = 10/group: excisional wound (EW) group—without local or systemic treatment; the EW + microcurrent treatment (EW + MC) group (300 [326.0, 244.0, 1124.0, 369.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
41 3 4 paragraph_title 2.2. Excisional Wound Model [328.0, 387.0, 578.0, 410.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.2. Excisional Wound Model"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
42 3 5 text The wound model was made using a circular excision as described by Mendes [21]. The animals were anesthetized with 4% isoflurane. The dorsal region of each animal was shaved, cleaned, and disinfected [325.0, 417.0, 1125.0, 546.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
43 3 6 paragraph_title 2.3. Treatment [328.0, 564.0, 455.0, 588.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.3. Treatment"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
44 3 7 text The animals received microcurrent treatment using a Ibramed Striat Esthetic $ ^{\circledR} $ (Ibramed, São Paulo, Brazil) device with the function of a microgalvanic ( $ \mu $A) current lasting 20 min [326.0, 594.0, 1125.0, 720.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
45 3 8 text The first treatment session started 24 h after the injury, and the others were performed daily until the seventh day. The area treated with iontophoresis was the dorsal region, which was submitted to [326.0, 720.0, 1124.0, 848.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
46 3 9 paragraph_title 2.4. Euthanasia [328.0, 865.0, 465.0, 890.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.4. Euthanasia"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
47 3 10 text The animals were euthanized 12 h after the last application of the MC, HA, and/or GNPs. After that, the external border of the wound was surgically removed and immediately processed and stored in a fr [326.0, 897.0, 1124.0, 974.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
48 3 11 paragraph_title 2.5. Synthesis and Characterization of the GNPs [328.0, 992.0, 728.0, 1017.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.5. Synthesis and Characterization of the GNPs"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
49 3 12 text Next, 20 nm GNPs were synthesized using the Turkevish method adapted by Della Vechia et al. [25]. The GNP solution was characterized using ultraviolet–visible (UV–VIS) spectroscopy with a spectrophoto [325.0, 1023.0, 1124.0, 1199.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
50 3 13 paragraph_title 2.6. Wound Size Analysis [328.0, 1217.0, 546.0, 1242.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.6. Wound Size Analysis"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
51 3 14 text Digital images of the wounds were taken at a resolution of $ 3264 \times 2448 $ pixels and analyzed using ImageJ $ ^{\textregistered} $ 1.51 software (National Institute of Mental Health, Bethesda, M [326.0, 1249.0, 1124.0, 1400.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
52 3 15 paragraph_title 2.7. Histomorphometry [328.0, 1420.0, 526.0, 1445.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.7. Histomorphometry"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
53 3 16 text The wound samples of four animals per group were conditioned for 48 h in a 10% formaldehyde-buffered solution (pH 7.4 phosphate buffer), followed by histological processing, and they were then embedde [326.0, 1450.0, 1124.0, 1553.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
54 4 0 header Antioxidants 2022, 11, 2257 [67.0, 111.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
55 4 1 number 4 of 15 [1069.0, 111.0, 1121.0, 131.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
56 4 2 text inflammatory infiltrate, blood vessels, and fibroblasts. Moreover, Ponceau S staining was performed to quantify the percentage area of total collagen compaction [29–32]. [325.0, 192.0, 1122.0, 242.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
57 4 3 text Furthermore, all histological sections were visualized using a LEICA $ ^{\circledR} $ DM-2000B optical microscope with a LEICA $ ^{\circledR} $ DFC-300 FX (Leica Microsystems, Wetzlar, Germany) camera [326.0, 242.0, 1123.0, 341.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
58 4 4 text For a simultaneous quantification (evaluated by a trained pathologist) of the inflammatory infiltrate and fibroblasts, the “Cell Counter” plugin in ImageJ software (5 images/animal/time/treatment in 4 [326.0, 343.0, 1126.0, 520.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
59 4 5 paragraph_title 2.8. Determination of Cytokine Content Using ELISA [328.0, 537.0, 774.0, 562.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.8. Determination of Cytokine Content Using ELISA"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
60 4 6 text The samples were processed, and then the plate was sensitized for further incubation with the antibody. To measure cytokines (IFN $ \gamma $, TNF- $ \alpha $, IL-1 $ \beta $, IL-6, IL-4, IL-10, TGF- $ [326.0, 569.0, 1124.0, 671.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
61 4 7 paragraph_title 2.9. Biochemical Analysis [328.0, 688.0, 545.0, 713.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.9. Biochemical Analysis"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
62 4 8 text Tissue determination of Reactive Oxygen Species (ROS) and nitric oxide: The production of hydroperoxides was determined by the intracellular formation of 2',7' dichlorofluorescein (DCF) by ROS as desc [326.0, 720.0, 1124.0, 820.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
63 4 9 text Tissue determination of oxidative damage marker levels: The oxidative damage to protein in the homogenized skin tissue samples was measured by the determination of carbonyl groups. The total thiol con [326.0, 822.0, 1124.0, 920.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
64 4 10 text Tissue determination of antioxidant defenses: SOD was measured in homogenized skin tissue by the inhibition of adrenaline oxidation, which was adapted from Bannister and Calabrese [35]. A standard cur [326.0, 921.0, 1123.0, 1020.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
65 4 11 text Protein Content: The protein content in homogenized skin tissue was measured following the protocol from Corrêa et al. [34]. [327.0, 1021.0, 1121.0, 1072.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
66 4 12 paragraph_title 2.10. Statistical Analysis [328.0, 1091.0, 540.0, 1115.0] subsection_heading 0.85 ["paragraph_title label with numbering: 2.10. Statistical Analysis"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
67 4 13 text Data are expressed as the mean ± standard error, and they were analyzed statistically using one-way analysis of variance (ANOVA) tests, followed by Tukey's post hoc tests. The significance level for t [326.0, 1122.0, 1123.0, 1225.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
68 4 14 paragraph_title 3. Results [328.0, 1244.0, 426.0, 1266.0] section_heading 0.85 ["paragraph_title label with numbering: 3. Results"] section_heading 0.85 body_zone heading_like heading_numbered True True
69 4 15 paragraph_title 3.1. Physicochemical Properties of the GNP Solution [328.0, 1269.0, 760.0, 1295.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.1. Physicochemical Properties of the GNP Solution"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
70 4 16 text To evaluate the formation and physical–chemical properties of the GNPs, UV–VIS, DLS, and zeta potential analyses were performed. The GNPs presented a maximum absorption peak at 524 nm and a ruby red c [326.0, 1301.0, 1124.0, 1501.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
71 5 0 header Antioxidants 2022, 11, 2257 [67.0, 111.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
72 5 1 number 5 of 15 [1069.0, 111.0, 1121.0, 132.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
73 5 2 chart [334.0, 191.0, 1100.0, 572.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
74 5 3 figure_title Figure 1. UV–VIS spectroscopy (A) and TEM images (B) of the GNP solution were obtained. [327.0, 590.0, 1065.0, 614.0] figure_caption 0.92 ["figure_title label: Figure 1. UV\u2013VIS spectroscopy (A) and TEM images (B) of the "] figure_caption 0.92 display_zone legend_like figure_number True True
75 5 4 paragraph_title 3.2. Analysis of the Wound Contraction Rate [328.0, 629.0, 703.0, 654.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.2. Analysis of the Wound Contraction Rate"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
76 5 5 text We evaluated the wound contraction rate in %, represented by the reduction in the surface area (Figure 2), where all treated groups showed a significant difference compared to the control group. [326.0, 660.0, 1122.0, 737.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
77 5 6 chart [186.0, 756.0, 1015.0, 1034.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
78 5 7 figure_title Figure 2. Effects of treatment with MC, GNPs, and hyaluronic acid on wound contraction. The data are presented in mean ± EPM, in which **p < 0.01 vs. excisional wound group (EW) and ***p < 0.001 vs. e [326.0, 1056.0, 1121.0, 1133.0] figure_caption 0.92 ["figure_title label: Figure 2. Effects of treatment with MC, GNPs, and hyaluronic"] figure_caption 0.92 display_zone legend_like figure_number True True
79 5 8 paragraph_title 3.3. Histological Analysis [328.0, 1148.0, 546.0, 1172.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.3. Histological Analysis"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
80 5 9 text In Figures 3 and 4, representative images of the histological sections of the integumentary system can be seen. A decrease in the mean number of inflammatory infiltrates was found in the EW + MC group [326.0, 1180.0, 1124.0, 1303.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
81 5 10 text Despite analyzing the percentage of collagen area (Figure 4B), no significant difference was observed between the groups. [326.0, 1304.0, 1123.0, 1354.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
82 6 0 header Antioxidants 2022, 11, 2257 [66.0, 110.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
83 6 1 number 6 of 15 [1069.0, 111.0, 1121.0, 131.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
84 6 2 figure_title A) [334.0, 189.0, 365.0, 221.0] figure_inner_text 0.9 ["panel label / figure inner text: A)"] figure_inner_text 0.9 display_zone legend_like panel_label True True
85 6 3 image [368.0, 200.0, 1078.0, 365.0] media_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
86 6 4 vision_footnote ■ Excisional Wound (EW) ■ EW + MC ■ EW + MC + HA ■ EW + MC + GNPs ■ EW + MC + HA + GNPs [569.0, 383.0, 885.0, 545.0] footnote 0.7 ["vision_footnote label: \u25a0 Excisional Wound (EW)\n\u25a0 EW + MC\n\u25a0 EW + MC + HA\n\u25a0 EW + MC +"] footnote 0.7 body_zone unknown_like none True True
87 6 5 figure_title B) [333.0, 546.0, 364.0, 577.0] figure_inner_text 0.9 ["panel label / figure inner text: B)"] figure_inner_text 0.9 display_zone legend_like panel_label True True
88 6 6 figure_title C) [705.0, 547.0, 735.0, 577.0] figure_inner_text 0.9 ["panel label / figure inner text: C)"] figure_inner_text 0.9 display_zone legend_like panel_label True True
89 6 7 chart [337.0, 550.0, 701.0, 799.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
90 6 8 chart [717.0, 552.0, 1055.0, 797.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
91 6 9 figure_title Figure 3. (A) Representative images of the histological sections of the integumentary system. (B,C) Effects of treatment with MC, GNPs, and hyaluronic acid on the number of inflammatory infiltrates (B [326.0, 813.0, 1125.0, 917.0] figure_caption 0.92 ["figure_title label: Figure 3. (A) Representative images of the histological sect"] figure_caption 0.92 display_zone legend_like figure_number True True
92 6 10 figure_title A) [332.0, 930.0, 363.0, 958.0] figure_inner_text 0.9 ["panel label / figure inner text: A)"] figure_inner_text 0.9 display_zone legend_like panel_label True True
93 6 11 image [353.0, 939.0, 1098.0, 1110.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
94 6 12 figure_title B) [333.0, 1122.0, 365.0, 1154.0] figure_inner_text 0.9 ["panel label / figure inner text: B)"] figure_inner_text 0.9 display_zone legend_like panel_label True True
95 6 13 chart [338.0, 1125.0, 1107.0, 1422.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
96 6 14 figure_title Figure 4. (A) Representative images of the histological sections of the integumentary system. (B) Effects of treatment with MC, GNPs, and hyaluronic acid on the % of collagen area. The data are presen [326.0, 1439.0, 1125.0, 1515.0] figure_caption 0.92 ["figure_title label: Figure 4. (A) Representative images of the histological sect"] figure_caption 0.92 display_zone legend_like figure_number True True
97 7 0 header Antioxidants 2022, 11, 2257 [66.0, 111.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
98 7 1 number 7 of 15 [1068.0, 110.0, 1121.0, 132.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
99 7 2 paragraph_title 3.4. Evaluation of Pro-Inflammatory Cytokines [327.0, 192.0, 717.0, 217.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.4. Evaluation of Pro-Inflammatory Cytokines"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
100 7 3 text Figure 5 shows the protein levels of pro-inflammatory cytokines. In Figure 5A, INFγ levels decreased in the EW + MC + HA group (p < 0.05) and in the combined therapy group (p < 0.01) when compared to [325.0, 224.0, 1126.0, 400.0] body_paragraph 0.9 ["figure caption candidate (body narrative): Figure 5 shows the protein levels of pro-inflammatory cytoki"] figure_caption_candidate 0.9 display_zone legend_like figure_number True True
101 7 4 figure_title A [334.0, 417.0, 356.0, 439.0] figure_inner_text 0.9 ["panel label / figure inner text: A"] figure_inner_text 0.9 display_zone legend_like panel_label True True
102 7 5 chart [339.0, 418.0, 666.0, 627.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
103 7 6 figure_title B [677.0, 417.0, 696.0, 438.0] figure_inner_text 0.9 ["panel label / figure inner text: B"] figure_inner_text 0.9 display_zone legend_like panel_label True True
104 7 7 chart [680.0, 422.0, 1013.0, 625.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
105 7 8 chart [601.0, 638.0, 810.0, 755.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
106 7 9 figure_title C [333.0, 766.0, 353.0, 787.0] figure_inner_text 0.9 ["panel label / figure inner text: C"] figure_inner_text 0.9 display_zone legend_like panel_label True True
107 7 10 figure_title D [676.0, 766.0, 697.0, 787.0] figure_inner_text 0.9 ["panel label / figure inner text: D"] figure_inner_text 0.9 display_zone legend_like panel_label True True
108 7 11 chart [339.0, 782.0, 663.0, 983.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
109 7 12 chart [693.0, 784.0, 1011.0, 982.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
110 7 13 figure_title Figure 5. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of pro-inflammatory cytokines: (A) INF-Y, (B) TNF-α, (C) IL1-β, (D) IL6. The data are presented in mean ± EPM, i [325.0, 995.0, 1124.0, 1123.0] figure_caption 0.92 ["figure_title label: Figure 5. Effects of treatment with MC, GNPs, and hyaluronic"] figure_caption 0.92 display_zone legend_like figure_number True True
111 7 14 paragraph_title 3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Factors [327.0, 1138.0, 892.0, 1163.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.5. Evaluation of Anti-Inflammatory Cytokines and Growth Fa"] subsection_heading 0.85 body_zone body_like heading_numbered True True
112 7 15 text The protein levels of anti-inflammatory cytokines are shown in Figure 6. The levels of IL-4 (Figure 6A) and IL10 (Figure 6B) were increased in the EW + MC + HA and EW + MC + HA + GNPs groups in relati [326.0, 1171.0, 1124.0, 1244.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
113 7 16 text The group treated with only the microcurrent (EW + MC) and the group in which the therapies were combined (EW + MC + HA + GNPs) showed a significant increase in the levels of TGF- $ \beta $ (Figure 6C [326.0, 1245.0, 1124.0, 1370.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
114 7 17 paragraph_title 3.6. Intracellular Determination of Oxidants [328.0, 1389.0, 699.0, 1414.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.6. Intracellular Determination of Oxidants"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
115 7 18 text It can be seen that only the group treated with the combined therapies (EW + MC + HA + GNPs) had their oxidant levels of DCFH (Figure 7A) and nitrite (Figure 7B) decreased when compared to the control [326.0, 1419.0, 1124.0, 1497.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
116 8 0 header Antioxidants 2022, 11, 2257 [66.0, 110.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
117 8 1 number 8 of 15 [1068.0, 111.0, 1121.0, 132.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
118 8 2 figure_title A [335.0, 191.0, 357.0, 215.0] figure_inner_text 0.9 ["panel label / figure inner text: A"] figure_inner_text 0.9 display_zone legend_like panel_label True True
119 8 3 chart [338.0, 194.0, 659.0, 399.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
120 8 4 figure_title B [677.0, 191.0, 697.0, 214.0] figure_inner_text 0.9 ["panel label / figure inner text: B"] figure_inner_text 0.9 display_zone legend_like panel_label True True
121 8 5 chart [682.0, 202.0, 1004.0, 398.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
122 8 6 chart [591.0, 410.0, 801.0, 529.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
123 8 7 figure_title C [332.0, 536.0, 353.0, 558.0] figure_inner_text 0.9 ["panel label / figure inner text: C"] figure_inner_text 0.9 display_zone legend_like panel_label True True
124 8 8 chart [337.0, 546.0, 660.0, 744.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
125 8 9 figure_title D [677.0, 537.0, 698.0, 558.0] figure_inner_text 0.9 ["panel label / figure inner text: D"] figure_inner_text 0.9 display_zone legend_like panel_label True True
126 8 10 chart [682.0, 550.0, 1003.0, 743.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
127 8 11 figure_title Figure 6. Effects of treatment with MC, GNPs, and hyaluronic acid on the protein levels of anti-inflammatory cytokines: (A) IL4; (B) IL10; (C) TGF- $ \beta $; (D) FGF. The data are presented in mean [326.0, 755.0, 1125.0, 859.0] figure_caption 0.92 ["figure_title label: Figure 6. Effects of treatment with MC, GNPs, and hyaluronic"] figure_caption 0.92 display_zone legend_like figure_number True True
128 8 12 figure_title A [333.0, 876.0, 356.0, 902.0] figure_inner_text 0.9 ["panel label / figure inner text: A"] figure_inner_text 0.9 display_zone legend_like panel_label True True
129 8 13 chart [335.0, 888.0, 768.0, 1146.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
130 8 14 chart [789.0, 941.0, 1016.0, 1220.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
131 8 15 figure_title B [333.0, 1167.0, 355.0, 1191.0] figure_inner_text 0.9 ["panel label / figure inner text: B"] figure_inner_text 0.9 display_zone legend_like panel_label True True
132 8 16 chart [354.0, 1179.0, 763.0, 1430.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
133 8 17 figure_title Figure 7. Effects of treatment with MC, GNPs, and hyaluronic acid on the levels of oxidants: (A) DCF; (B) nitrate. The data are presented in mean ± EPM, in which *p < 0.05 vs. excisional wound group ( [326.0, 1444.0, 1124.0, 1521.0] figure_caption 0.92 ["figure_title label: Figure 7. Effects of treatment with MC, GNPs, and hyaluronic"] figure_caption 0.92 display_zone legend_like figure_number True True
134 9 0 header Antioxidants 2022, 11, 2257 [66.0, 110.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
135 9 1 number 9 of 15 [1068.0, 110.0, 1121.0, 131.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
136 9 2 paragraph_title 3.7. Markers of Oxidative Damage and Antioxidants [327.0, 191.0, 764.0, 217.0] subsection_heading 0.85 ["paragraph_title label with numbering: 3.7. Markers of Oxidative Damage and Antioxidants"] subsection_heading 0.85 body_zone heading_like heading_numbered True True
137 9 3 text Carbonyl levels had a significant decrease in the EW + MC + HA + GNI's group compared to the EW group (Figure 8A). When the sulfhydryl content was evaluated (Figure 8B), we observed that the EW + MC + [325.0, 223.0, 1124.0, 351.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
138 9 4 figure_title A [333.0, 373.0, 357.0, 398.0] figure_inner_text 0.9 ["panel label / figure inner text: A"] figure_inner_text 0.9 display_zone legend_like panel_label True True
139 9 5 chart [337.0, 381.0, 697.0, 606.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
140 9 6 figure_title B [724.0, 373.0, 747.0, 396.0] figure_inner_text 0.9 ["panel label / figure inner text: B"] figure_inner_text 0.9 display_zone legend_like panel_label True True
141 9 7 chart [728.0, 385.0, 1097.0, 605.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
142 9 8 chart [622.0, 623.0, 857.0, 749.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
143 9 9 figure_title C [345.0, 766.0, 367.0, 791.0] figure_inner_text 0.9 ["panel label / figure inner text: C"] figure_inner_text 0.9 display_zone legend_like panel_label True True
144 9 10 chart [347.0, 769.0, 699.0, 992.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
145 9 11 figure_title D [720.0, 766.0, 743.0, 790.0] figure_inner_text 0.9 ["panel label / figure inner text: D"] figure_inner_text 0.9 display_zone legend_like panel_label True True
146 9 12 chart [725.0, 773.0, 1098.0, 991.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
147 9 13 figure_title Figure 8. Effects of treatment with MIC, GNPs, and hyaluronic acid on the levels of oxidative damage markers and antioxidants: (A) carbonyl; (B) sulfhydryl; (C) SOD; (D) GSH. The data are presented in [326.0, 1005.0, 1123.0, 1134.0] figure_caption 0.92 ["figure_title label: Figure 8. Effects of treatment with MIC, GNPs, and hyaluroni"] figure_caption 0.92 display_zone legend_like figure_number True True
148 9 14 text Antioxidant defense was measured through reduced glutathione and superoxide dismutase levels. SOD levels (Figure 8C) showed a significant decrease in the combined therapy group (EW + MC + HA + GNPs). [324.0, 1152.0, 1123.0, 1255.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
149 9 15 paragraph_title 4. Discussion [328.0, 1273.0, 458.0, 1296.0] section_heading 0.85 ["paragraph_title label with numbering: 4. Discussion"] section_heading 0.85 body_zone heading_like heading_numbered True True
150 9 16 text Wounds are a big problem in terms of social impact, and despite the wide range of therapies that can promote the repair of epithelial lesions, the incidence of wounds is progressively increasing, sinc [324.0, 1304.0, 1123.0, 1505.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
151 9 17 text Clinical studies have reported positive wound healing results using electrical stimulation, and for a while, it has been utilized in clinical practice to speed up wound heal- [326.0, 1506.0, 1127.0, 1556.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
152 10 0 header Antioxidants 2022, 11, 2257 [67.0, 111.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
153 10 1 header 10 of 15 [1062.0, 111.0, 1121.0, 132.0] noise 0.9 ["header label"] noise 0.9 reference_like reference_numeric_dot False False
154 10 2 text ing [37,38]. An MC is a specific type of microampere ( $ \mu $A) electrical stimulation that replicates currents generated in the body at the cellular level, and it is known to boost cell physiology a [324.0, 192.0, 1125.0, 443.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
155 10 3 text In line with what has been exposed, in the present study, a reduction in the levels of pro-inflammatory cytokines (IFN $ \gamma $, TNF $ \alpha $, IL-1 $ \beta $, and IL6) and inflammatory infiltrates [325.0, 444.0, 1124.0, 568.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
156 10 4 text Individually, each therapy promotes some mechanisms of action in the tissue, and, when combined, they can potentiate their isolated effects. MCs allow the transport of bioactive molecules when combine [325.0, 569.0, 1126.0, 870.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
157 10 5 text Likewise, the use of GNPs can act as an anti-inflammatory agent in the treatment of various models of tissue injury [49] by blocking the activation of nuclear factor kappa β (NF-κB) and combining with [323.0, 870.0, 1124.0, 1196.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
158 10 6 text Only in the group receiving combination treatment was it possible to see an increase in anti-inflammatory cytokines and growth factors, together with a decline in pro-inflammatory cytokines. According [325.0, 1197.0, 1126.0, 1550.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
159 11 0 header Antioxidants 2022, 11, 2257 [67.0, 110.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 tail_nonref_hold_zone unknown_like none False False
160 11 1 header 11 of 15 [1062.0, 111.0, 1121.0, 132.0] noise 0.9 ["header label"] noise 0.9 reference_like reference_numeric_dot False False
161 11 2 text The effects attributed to HA describe the modulation of pathways that include the suppression of pro-inflammatory cytokines and chemokines [57], in addition to improving membrane stability and favorin [325.0, 192.0, 1124.0, 443.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
162 11 3 text By reducing the formation of reactive oxygen and nitrogen species, reducing oxidative damage, and stimulating the antioxidant system, the group that was subjected to the combination of the suggested t [325.0, 444.0, 1125.0, 644.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
163 11 4 text The capacity of HA to bind to the CD44 receptor, activate pathways involved in the control of cellular redox status, produce intracellular ROS, and chelate $ Fe^{2+} $ and $ Cu^{2+} $ ions—which are [326.0, 644.0, 1124.0, 795.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
164 11 5 text Likewise, as an antioxidant agent, GNPs exhibit high catalytic activity for free radical scavenging reactions, affecting the thiol bonds of keap1, causing a conformational change that allows the relea [325.0, 795.0, 1124.0, 970.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
165 11 6 text Since excessive levels of ROS in a wound pose a barrier to the healing process, our results show the potential of combined treatments (MC + HA + GNPs) to restore tissue redox homeostasis and to create [326.0, 971.0, 1123.0, 1045.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
166 11 7 text Our findings demonstrate that the groups who received MC in conjunction with the topical application of compounds had a reduction in the inflammatory infiltrate when compared to the lesion group, whic [325.0, 1046.0, 1124.0, 1246.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
167 11 8 text In line with that previously discussed, when evaluating the wound contraction rate in %, this study shows that all therapeutic approaches can promote the healing process by causing the wound to shrink [326.0, 1247.0, 1124.0, 1422.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone body_like none True True
168 11 9 text Taken together, these results are in agreement with those found in the study conducted by Mendes et al. (2020), where the benefits of using HA in combination with GNPs were also demonstrated and where [325.0, 1422.0, 1125.0, 1525.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
169 12 0 header Antioxidants 2022, 11, 2257 [67.0, 111.0, 259.0, 132.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
170 12 1 number 12 of 15 [1062.0, 111.0, 1121.0, 132.0] noise 0.9 ["page number label"] noise 0.9 reference_like reference_numeric_dot False False
171 12 2 paragraph_title 5. Conclusions [328.0, 192.0, 471.0, 216.0] section_heading 0.85 ["paragraph_title label with numbering: 5. Conclusions"] section_heading 0.85 body_zone heading_like heading_numbered True True
172 12 3 text The proposed therapies, when combined, seem to enhance their mechanisms of action, with promising effects in the control of the acute inflammatory response, accelerating the transition to the prolifer [325.0, 224.0, 1123.0, 298.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
173 12 4 text As a proposal for further studies, it is believed that, with longer analysis periods (between 14 and 21 days), the response of the combined therapy group (EW + MC + HA + GNPs) would have greater reper [325.0, 299.0, 1124.0, 377.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
174 12 5 text Author Contributions: C.M.—Conceptualization, Data acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing—original draft, Writing—r [325.0, 398.0, 1125.0, 633.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone support_like none True True
175 12 6 text Funding: This research was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant number [Call CNPq 06/2019—Research Productivity Scholarships], Fundação de Amparo à Pesq [326.0, 643.0, 1125.0, 762.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
176 12 7 text Institutional Review Board Statement: The animal study protocol was approved by the University Ethics Committee (Universidade do Extremo Sul Catarinense—UNESC) with protocol number 16/2020. [325.0, 772.0, 1124.0, 820.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
177 12 8 text Informed Consent Statement: Not applicable. [328.0, 832.0, 704.0, 854.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
178 12 9 text Data Availability Statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request. [327.0, 867.0, 1122.0, 914.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
179 12 10 text Conflicts of Interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article. [326.0, 926.0, 1122.0, 973.0] frontmatter_noise 0.88 ["default body_paragraph for text label", "late role resolution: editorial phrase cross-validates non-body classification", "zone=body_zone", "style_family=support_like"] body_paragraph 0.6 body_zone support_like none False False
180 12 11 paragraph_title References [67.0, 992.0, 175.0, 1015.0] reference_heading 0.9 ["references heading: References"] reference_heading 0.9 reference_zone heading_like short_fragment True True
181 12 12 reference_content 1. Martinengo, L.; Olsson, M.; Bajpai, R.; Soljak, M.; Upton, Z.; Schmidtchen, A.; Car, J.; Järbrink, K. Prevalence of chronic wounds in the general population: Systematic review and meta-analysis of [65.0, 1022.0, 1122.0, 1089.0] reference_item 0.85 ["reference content label: 1. Martinengo, L.; Olsson, M.; Bajpai, R.; Soljak, M.; Upton"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
182 12 13 reference_content 2. Nussbaum, S.R.; Carter, M.J.; Fife, C.E.; DaVanzo, J.; Haught, R.; Nusgart, M.; Cartwright, D. An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wou [66.0, 1092.0, 1122.0, 1159.0] reference_item 0.85 ["reference content label: 2. Nussbaum, S.R.; Carter, M.J.; Fife, C.E.; DaVanzo, J.; Ha"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
183 12 14 reference_content 3. Holzer-Geissler, J.C.J.; Schwingenschuh, S.; Zacharias, M.; Einsiedler, J.; Kainz, S.; Reisenegger, P.; Holecek, C.; Hofmann, E.; Wolff-Winiski, B.; Fahrngruber, H.; et al. The Impact of Prolonged [66.0, 1162.0, 1123.0, 1228.0] reference_item 0.85 ["reference content label: 3. Holzer-Geissler, J.C.J.; Schwingenschuh, S.; Zacharias, M"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
184 12 15 reference_content 4. Rajendran, S.B.; Challen, K.; Wright, K.L.; Hardy, J.G. Electrical Stimulation to Enhance Wound Healing. J. Funct. Biomater. 2021, 12, 40. [CrossRef] [68.0, 1231.0, 1122.0, 1275.0] reference_item 0.85 ["reference content label: 4. Rajendran, S.B.; Challen, K.; Wright, K.L.; Hardy, J.G. E"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
185 12 16 reference_content 5. Sahana, T.G.; Rekha, P.D. Biopolymers: Applications in wound healing and skin tissue engineering. Mol. Biol. Rep. 2018, 45, 2857–2867. [CrossRef] [67.0, 1277.0, 1122.0, 1320.0] reference_item 0.85 ["reference content label: 5. Sahana, T.G.; Rekha, P.D. Biopolymers: Applications in wo"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
186 12 17 reference_content 6. Veith, A.P.; Henderson, K.; Spencer, A.; Sligar, A.D.; Baker, A.B. Therapeutic strategies for enhancing angiogenesis in wound healing. Adv. Drug Deliv. Rev. 2019, 146, 97–125. [CrossRef] [67.0, 1323.0, 1120.0, 1367.0] reference_item 0.85 ["reference content label: 6. Veith, A.P.; Henderson, K.; Spencer, A.; Sligar, A.D.; Ba"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
187 12 18 reference_content 7. Zaccaron, R.P.; Barbieri, R.T.; Mendes, C.; Venturini, L.M.; Alves, N.; Mariano, S.S.; de Andrade, T.A.M.; Hermes de Araújo, P.H.; Feuser, P.E.; Thirupathi, A.; et al. Photobiomodulation associated [66.0, 1369.0, 1121.0, 1436.0] reference_item 0.85 ["reference content label: 7. Zaccaron, R.P.; Barbieri, R.T.; Mendes, C.; Venturini, L."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
188 12 19 reference_content 8. Foulds, I.S.; Barker, A.T. Human skin battery potentials and their possible role in wound healing. Br. J. Dermatol. 1983, 109, 515–522. [CrossRef] [66.0, 1438.0, 1122.0, 1481.0] reference_item 0.85 ["reference content label: 8. Foulds, I.S.; Barker, A.T. Human skin battery potentials "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
189 12 20 reference_content 9. Nair, H.K.R. Microcurrent as an adjunct therapy to accelerate chronic wound healing and reduce patient pain. J. Wound Care 2018, 27, 296–306. [CrossRef] [66.0, 1484.0, 1123.0, 1527.0] reference_item 0.85 ["reference content label: 9. Nair, H.K.R. Microcurrent as an adjunct therapy to accele"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
190 13 0 header Antioxidants 2022, 11, 2257 [66.0, 111.0, 259.0, 131.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
191 13 1 number 13 of 15 [1061.0, 111.0, 1122.0, 131.0] noise 0.9 ["page number label"] noise 0.9 reference_zone reference_like reference_numeric_dot False False
192 13 2 reference_content 10. Poltawski, L.; Watson, T. Bioelectricity and microcurrent therapy for tissue healing—A narrative review. Phys. Ther. Rev. 2009, 14, 104–114. [CrossRef] [66.0, 193.0, 1122.0, 237.0] reference_item 0.85 ["reference content label: 10. Poltawski, L.; Watson, T. Bioelectricity and microcurren"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
193 13 3 reference_content 11. Vieira, A.C.; Reid, B.; Cao, L.; Mannis, M.J.; Schwab, I.R.; Zhao, M. Ionic components of electric current at rat corneal wounds. PLoS ONE 2011, 6, e17411. [CrossRef] [PubMed] [67.0, 240.0, 1122.0, 284.0] reference_item 0.85 ["reference content label: 11. Vieira, A.C.; Reid, B.; Cao, L.; Mannis, M.J.; Schwab, I"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
194 13 4 reference_content 12. Jennings, J.; Chen, D.; Feldman, D. Transcriptional response of dermal fibroblasts in direct current electric fields. Bioelectromagnetics 2008, 29, 394–405. [CrossRef] [PubMed] [67.0, 285.0, 1122.0, 329.0] reference_item 0.85 ["reference content label: 12. Jennings, J.; Chen, D.; Feldman, D. Transcriptional resp"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
195 13 5 reference_content 13. Alvarez, O.M.; Mertz, P.M.; Smerbeck, R.V.; Eaglstein, W.H. The healing of superficial skin wounds is stimulated by external electrical current. J. Investig. Dermatol. 1983, 81, 144–148. [CrossRef [67.0, 332.0, 1119.0, 376.0] reference_item 0.85 ["reference content label: 13. Alvarez, O.M.; Mertz, P.M.; Smerbeck, R.V.; Eaglstein, W"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
196 13 6 reference_content 14. Zhao, M.; Bai, H.; Wang, E.; Forrester, J.V.; McCaig, C.D. Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. J. Ce [68.0, 378.0, 1121.0, 421.0] reference_item 0.85 ["reference content label: 14. Zhao, M.; Bai, H.; Wang, E.; Forrester, J.V.; McCaig, C."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
197 13 7 reference_content 15. Park, R.J.; Son, H.; Kim, K.; Kim, S.; Oh, T. The Effect of Microcurrent Electrical Stimulation on the Foot Blood Circulation and Pain of Diabetic Neuropathy. J. Phys. Ther. Sci. 2011, 23, 515–518 [69.0, 424.0, 1122.0, 468.0] reference_item 0.85 ["reference content label: 15. Park, R.J.; Son, H.; Kim, K.; Kim, S.; Oh, T. The Effect"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
198 13 8 reference_content 16. Clarke Moloney, M.; Lyons, G.M.; Breen, P.; Burke, P.E.; Grace, P.A. Haemodynamic study examining the response of venous blood flow to electrical stimulation of the gastrocnemius muscle in patient [68.0, 470.0, 1122.0, 537.0] reference_item 0.85 ["reference content label: 16. Clarke Moloney, M.; Lyons, G.M.; Breen, P.; Burke, P.E.;"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
199 13 9 reference_content 17. Sharifi, S.; Hajipour, M.J.; Gould, L.; Mahmoudi, M. Nanomedicine in Healing Chronic Wounds: Opportunities and Challenges. Mol. Pharm. 2021, 18, 550–575. [CrossRef] [68.0, 539.0, 1124.0, 582.0] reference_item 0.85 ["reference content label: 17. Sharifi, S.; Hajipour, M.J.; Gould, L.; Mahmoudi, M. Nan"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
200 13 10 reference_content 18. Mahmoudi, A.; Kesharwani, P.; Majeed, M.; Teng, Y.; Sahebkar, A. Recent advances in nanogold as a promising nanocarrier for curcumin delivery. Colloids Surfaces. B Biointerfaces 2022, 215, 112481. [68.0, 585.0, 1123.0, 629.0] reference_item 0.85 ["reference content label: 18. Mahmoudi, A.; Kesharwani, P.; Majeed, M.; Teng, Y.; Sahe"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
201 13 11 reference_content 19. da Rocha, F.R.; Haupenthal, D.P.d.S.; Zaccaron, R.P.; Corrêa, M.E.A.B.; Tramontin, N.d.S.; Fonseca, J.P.; Nesi, R.T.; Muller, A.P.; Pinho, R.A.; Paula, M.M.d.S.; et al. Therapeutic effects of iont [67.0, 631.0, 1123.0, 697.0] reference_item 0.85 ["reference content label: 19. da Rocha, F.R.; Haupenthal, D.P.d.S.; Zaccaron, R.P.; Co"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
202 13 12 reference_content 20. Akturk, O.; Kismet, K.; Yasti, A.C.; Kuru, S.; Duymus, M.E.; Kaya, F.; Caydere, M.; Hucumenoglu, S.; Keskin, D. Collagen/gold nanoparticle nanocomposites: A potential skin wound healing biomateria [66.0, 700.0, 1122.0, 745.0] reference_item 0.85 ["reference content label: 20. Akturk, O.; Kismet, K.; Yasti, A.C.; Kuru, S.; Duymus, M"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
203 13 13 reference_content 21. Mendes, C.; dos Santos Haupenthal, D.P.; Zaccaron, R.P.; de Bem Silveira, G.; Corrêa, M.E.A.B.; de Roch Casagrande, L.; de Sousa Mariano, S.; de Souza Silva, J.I.; de Andrade, T.A.M.; Feuser, P.E. [67.0, 747.0, 1120.0, 814.0] reference_item 0.85 ["reference content label: 21. Mendes, C.; dos Santos Haupenthal, D.P.; Zaccaron, R.P.;"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
204 13 14 reference_content 22. Kim, Y.; Lee, Y.-S.; Choe, J.; Lee, H.; Kim, Y.-M.; Jeoung, D. CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C sign [67.0, 815.0, 1122.0, 881.0] reference_item 0.85 ["reference content label: 22. Kim, Y.; Lee, Y.-S.; Choe, J.; Lee, H.; Kim, Y.-M.; Jeou"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
205 13 15 reference_content 23. Xu, Z.; Liu, G.; Liu, P.; Hu, Y.; Chen, Y.; Fang, Y.; Sun, G.; Huang, H.; Wu, J. Hyaluronic acid-based glucose-responsive antioxidant hydrogel platform for enhanced diabetic wound repair. Acta Bio [66.0, 884.0, 1122.0, 928.0] reference_item 0.85 ["reference content label: 23. Xu, Z.; Liu, G.; Liu, P.; Hu, Y.; Chen, Y.; Fang, Y.; Su"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
206 13 16 reference_content 24. Corrêa, M.; Mendes, C.; Bittencourt, J.V.S.; Takejima, A.; de Souza, I.C.; de Carvalho, S.C.D.; Orlandini, I.G.; de Andrade, T.A.M.; Guarita-Souza, L.C.; Silveira, P.C.L. Effects of the Applicatio [66.0, 931.0, 1123.0, 997.0] reference_item 0.85 ["reference content label: 24. Corr\u00eaa, M.; Mendes, C.; Bittencourt, J.V.S.; Takejima, A"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
207 13 17 reference_content 25. Wu, S.; Zhao, W.; Sun, M.; He, P.; Lv, H.; Wang, Q.; Ma, J. Novel bi-layered dressing patches constructed with radially-oriented nanofibrous pattern and herbal compound-loaded hydrogel for acceler [67.0, 999.0, 1122.0, 1065.0] reference_item 0.85 ["reference content label: 25. Wu, S.; Zhao, W.; Sun, M.; He, P.; Lv, H.; Wang, Q.; Ma,"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
208 13 18 reference_content 26. Wu, S.; Dong, T.; Li, Y.; Sun, M.; Qi, Y.; Liu, J.; Duan, B. State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applications. Appl. Mater. Today 2022, 27, [66.0, 1068.0, 1122.0, 1112.0] reference_item 0.85 ["reference content label: 26. Wu, S.; Dong, T.; Li, Y.; Sun, M.; Qi, Y.; Liu, J.; Duan"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
209 13 19 reference_content 27. Yu, R.; Zhang, H.; Guo, B. Conductive biomaterials as bioactive wound dressing for wound healing and skin tissue engineering. Nano-Micro Lett. 2022, 14, 1–46. [CrossRef] [67.0, 1115.0, 1124.0, 1158.0] reference_item 0.85 ["reference content label: 27. Yu, R.; Zhang, H.; Guo, B. Conductive biomaterials as bi"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
210 13 20 reference_content 28. Li, T.; Sun, M.; Wu, S. State-of-the-art review of electrospun gelatin-based nanofiber dressings for wound healing applications. Nanomaterials 2022, 12, 784. [CrossRef] [PubMed] [67.0, 1160.0, 1123.0, 1204.0] reference_item 0.85 ["reference content label: 28. Li, T.; Sun, M.; Wu, S. State-of-the-art review of elect"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
211 13 21 reference_content 29. Della Vechia, I.C.; Steiner, B.T.; Freitas, M.L.; Fidelis, G.d.S.P.; Galvani, N.C.; Ronchi, J.M.; Possato, J.C.; Fagundes, M.I.; Rigo, F.K.; Feuser, P.E.; et al. Comparative cytotoxic effect of ci [67.0, 1206.0, 1123.0, 1272.0] reference_item 0.85 ["reference content label: 29. Della Vechia, I.C.; Steiner, B.T.; Freitas, M.L.; Fideli"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
212 13 22 reference_content 30. Andrade, T.A.M.; Masson-Meyers, D.S.; Caetano, G.F.; Terra, V.A.; Ovidio, P.P.; Jordão-Júnior, A.A.; Frade, M.A.C. Skin changes in streptozotocin-induced diabetic rats. Biochem. Biophys. Res. Comm [67.0, 1275.0, 1120.0, 1319.0] reference_item 0.85 ["reference content label: 30. Andrade, T.A.M.; Masson-Meyers, D.S.; Caetano, G.F.; Ter"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
213 13 23 reference_content 31. Jiang, X.; Ge, H.; Zhou, C.; Chai, X.; Deng, H. The role of transforming growth factor $ \beta1 $ in fractional laser resurfacing with a carbon dioxide laser. Lasers Med. Sci. 2014, 29, 681–687. [68.0, 1321.0, 1121.0, 1365.0] reference_item 0.85 ["reference content label: 31. Jiang, X.; Ge, H.; Zhou, C.; Chai, X.; Deng, H. The role"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
214 13 24 reference_content 32. Vidal, B.C.; Mello, M.L.S. Supramolecular order following binding of the dichroic birefringent sulfonic dye Ponceau SS to collagen fibers. Biopolymers 2005, 78, 121–128. [CrossRef] [PubMed] [67.0, 1368.0, 1122.0, 1412.0] reference_item 0.85 ["reference content label: 32. Vidal, B.C.; Mello, M.L.S. Supramolecular order followin"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
215 13 25 reference_content 33. Curtolo, G.; de Paula Araújo, J.; Lima, J.A.; Brandt, J.V.; Bittencourt, J.V.S.; Venturini, L.M.; Silveira, P.C.L.; Rogers, S.; Franzini, C.M.; de Goes, V.F. Silver nanoparticles formulations for [67.0, 1414.0, 1124.0, 1480.0] reference_item 0.85 ["reference content label: 33. Curtolo, G.; de Paula Ara\u00fajo, J.; Lima, J.A.; Brandt, J."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
216 14 0 header Antioxidants 2022, 11, 2257 [66.0, 111.0, 259.0, 131.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
217 14 1 number 14 of 15 [1061.0, 111.0, 1122.0, 131.0] noise 0.9 ["page number label"] noise 0.9 reference_zone reference_like reference_numeric_dot False False
218 14 2 reference_content 34. Corrêa, M.E.A.B.; dos Santos Haupenthal, D.P.; Mendes, C.; Zaccaron, R.P.; de Roch Casagrande, L.; Venturini, L.M.; Porto, G.D.; Bittencourt, J.V.S.; de Souza Silva, J.I.; de Sousa Mariano, S.; et [66.0, 193.0, 1122.0, 283.0] reference_item 0.85 ["reference content label: 34. Corr\u00eaa, M.E.A.B.; dos Santos Haupenthal, D.P.; Mendes, C"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
219 14 3 reference_content 35. Bannister, J.V.; Calabrese, L. Assays for superoxide dismutase. Methods Biochem. Anal. 1987, 32, 279–312. [66.0, 285.0, 936.0, 307.0] reference_item 0.85 ["reference content label: 35. Bannister, J.V.; Calabrese, L. Assays for superoxide dis"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
220 14 4 reference_content 36. Dos Santos Haupenthal, D.P.; Mendes, C.; de Bem Silveira, G.; Zaccaron, R.P.; Correa, M.; Nesi, R.T.; Pinho, R.A.; da Silva Paula, M.M.; Silveira, P.C.L. Effects of treatment with gold nanoparticl [67.0, 309.0, 1123.0, 376.0] reference_item 0.85 ["reference content label: 36. Dos Santos Haupenthal, D.P.; Mendes, C.; de Bem Silveira"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
221 14 5 reference_content 37. Franek, A.; Kostur, R.; Polak, A.; Taradaj, J.; Szlachta, Z.; Blaszczak, E.; Dolibog, P.; Dolibog, P.; Koczy, B.; Kucio, C. Using high-voltage electrical stimulation in the treatment of recalcitra [67.0, 378.0, 1122.0, 444.0] reference_item 0.85 ["reference content label: 37. Franek, A.; Kostur, R.; Polak, A.; Taradaj, J.; Szlachta"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
222 14 6 reference_content 38. Polak, A.; Franek, A.; Taradaj, J. High-Voltage Pulsed Current Electrical Stimulation in Wound Treatment. Adv. Wound Care 2014, 3, 104–117. [CrossRef] [67.0, 447.0, 1123.0, 490.0] reference_item 0.85 ["reference content label: 38. Polak, A.; Franek, A.; Taradaj, J. High-Voltage Pulsed C"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
223 14 7 reference_content 39. Ahmed, A.F.; Elgayed, S.S.A.; Ibrahim, I.M. Polarity effect of microcurrent electrical stimulation on tendon healing: Biomechanical and histopathological studies. J. Adv. Res. 2012, 3, 109–117. [C [67.0, 493.0, 1124.0, 537.0] reference_item 0.85 ["reference content label: 39. Ahmed, A.F.; Elgayed, S.S.A.; Ibrahim, I.M. Polarity eff"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
224 14 8 reference_content 40. Kaur, U.; Banerjee, P.; Bir, A.; Sinha, M.; Biswas, A.; Chakrabarti, S. Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: The NF-kappaB connection. Curr. Top. [68.0, 539.0, 1124.0, 584.0] reference_item 0.85 ["reference content label: 40. Kaur, U.; Banerjee, P.; Bir, A.; Sinha, M.; Biswas, A.; "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
225 14 9 reference_content 41. Yu, C.; Hu, Z.-Q.; Peng, R.-Y.J.M.M.R. Effects and mechanisms of a microcurrent dressing on skin wound healing: A review. Mil. Med. Res. 2014, 1, 24. [CrossRef] [PubMed] [68.0, 585.0, 1123.0, 628.0] reference_item 0.85 ["reference content label: 41. Yu, C.; Hu, Z.-Q.; Peng, R.-Y.J.M.M.R. Effects and mecha"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
226 14 10 reference_content 42. Sugimoto, M.; Maeshige, N.; Honda, H.; Yoshikawa, Y.; Uemura, M.; Yamamoto, M.; Terashi, H. Optimum microcurrent stimulation intensity for galvanotaxis in human fibroblasts. J. Wound Care 2012, 21 [67.0, 631.0, 1123.0, 675.0] reference_item 0.85 ["reference content label: 42. Sugimoto, M.; Maeshige, N.; Honda, H.; Yoshikawa, Y.; Ue"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
227 14 11 reference_content 43. Lee, B.Y.; Al-Waili, N.; Stubbs, D.; Wendell, K.; Butler, G.; Al-Waili, T.; Al-Waili, A. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of t [67.0, 677.0, 1123.0, 743.0] reference_item 0.85 ["reference content label: 43. Lee, B.Y.; Al-Waili, N.; Stubbs, D.; Wendell, K.; Butler"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
228 14 12 reference_content 44. Wang, Y.; Zeng, L.; Song, W.; Liu, J. Influencing factors and drug application of iontophoresis in transdermal drug delivery: An overview of recent progress. Drug Deliv. Transl. Res. 2021, 12, 15– [67.0, 746.0, 1123.0, 790.0] reference_item 0.85 ["reference content label: 44. Wang, Y.; Zeng, L.; Song, W.; Liu, J. Influencing factor"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
229 14 13 reference_content 45. Petrilli, R.; Lopez, R.F.V. Physical methods for topical skin drug delivery: Concepts and applications. Braz. J. Pharm. Sci. 2018, 54, e01008. [CrossRef] [67.0, 792.0, 1122.0, 835.0] reference_item 0.85 ["reference content label: 45. Petrilli, R.; Lopez, R.F.V. Physical methods for topical"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
230 14 14 reference_content 46. Manabe, E.; Numajiri, S.; Sugibayashi, K.; Morimoto, Y. Analysis of skin permeation-enhancing mechanism of iontophoresis using hydrodynamic pore theory. J. Control. Release 2000, 66, 149–158. [Cro [66.0, 838.0, 1122.0, 883.0] reference_item 0.85 ["reference content label: 46. Manabe, E.; Numajiri, S.; Sugibayashi, K.; Morimoto, Y. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
231 14 15 reference_content 47. Arunkumar, S.; Ashok, P.; Desai, B.; Shivakumar, H.N. Technology. Effect of chemical penetration enhancer on transdermal iontophoretic delivery of diclofenac sodium under constant voltage. J. Drug [66.0, 884.0, 1122.0, 928.0] reference_item 0.85 ["reference content label: 47. Arunkumar, S.; Ashok, P.; Desai, B.; Shivakumar, H.N. Te"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
232 14 16 reference_content 48. Kim, J.W.; Shim, J.S.; Maeng, C.; Kim, Y.S.; Ahn, J.; Kwak, M.G.; Hong, S.J.; Cho, H.M. Fabrication of SiC nanoparticles by physical milling for ink-jet printing. J. Nanosci. Nanotechnol. 2013, 13 [66.0, 930.0, 1122.0, 974.0] reference_item 0.85 ["reference content label: 48. Kim, J.W.; Shim, J.S.; Maeng, C.; Kim, Y.S.; Ahn, J.; Kw"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
233 14 17 reference_content 49. Dohnert, M.B.; Venancio, M.; Possato, J.C.; Zeferino, R.C.; Dohnert, L.H.; Zugno, A.I.; De Souza, C.T.; Paula, M.M.; Luciano, T.F. Gold nanoparticles and diclofenac diethylammonium administered by [66.0, 976.0, 1122.0, 1043.0] reference_item 0.85 ["reference content label: 49. Dohnert, M.B.; Venancio, M.; Possato, J.C.; Zeferino, R."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
234 14 18 reference_content 50. Jeon, K.I.; Byun, M.S.; Jue, D.M. Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit. Exp. Mol. Med. 2003, 35, 61–66. [CrossRef] [67.0, 1045.0, 1122.0, 1089.0] reference_item 0.85 ["reference content label: 50. Jeon, K.I.; Byun, M.S.; Jue, D.M. Gold compound auranofi"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
235 14 19 reference_content 51. Sumbayev, V.V.; Yasinska, I.M.; Garcia, C.P.; Gilliland, D.; Lall, G.S.; Gibbs, B.F.; Bonsall, D.R.; Varani, L.; Rossi, F.; Calzolai, L. Gold nanoparticles downregulate interleukin-1beta-induced p [67.0, 1091.0, 1124.0, 1157.0] reference_item 0.85 ["reference content label: 51. Sumbayev, V.V.; Yasinska, I.M.; Garcia, C.P.; Gilliland,"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
236 14 20 reference_content 52. Boomi, P.; Ganesan, R.; Poorani, G.P.; Jegatheeswaran, S.; Balakumar, C.; Prabu, H.G.; Anand, K.; Prabhu, N.M.; Jeyakanthan, J.; Saravanan, M. Phyto-Engineered Gold Nanoparticles (AuNPs) with Pote [66.0, 1160.0, 1123.0, 1228.0] reference_item 0.85 ["reference content label: 52. Boomi, P.; Ganesan, R.; Poorani, G.P.; Jegatheeswaran, S"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
237 14 21 reference_content 53. Ni, C.; Zhou, J.; Kong, N.; Bian, T.; Zhang, Y.; Huang, X.; Xiao, Y.; Yang, W.; Yan, F. Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontit [67.0, 1229.0, 1123.0, 1295.0] reference_item 0.85 ["reference content label: 53. Ni, C.; Zhou, J.; Kong, N.; Bian, T.; Zhang, Y.; Huang, "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
238 14 22 reference_content 54. Nguyen, V.-L.; Truong, C.-T.; Nguyen, B.C.Q.; Vo, T.-N.V.; Dao, T.-T.; Nguyen, V.-D.; Trinh, D.-T.T.; Huynh, H.K.; Bui, C.-B. Anti-inflammatory and wound healing activities of calophyllolide isola [67.0, 1298.0, 1123.0, 1365.0] reference_item 0.85 ["reference content label: 54. Nguyen, V.-L.; Truong, C.-T.; Nguyen, B.C.Q.; Vo, T.-N.V"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
239 14 23 reference_content 55. Singer, A.J.; Clark, R.A. Cutaneous wound healing. N. Engl. J. Med. 1999, 341, 738–746. [CrossRef] [67.0, 1367.0, 890.0, 1390.0] reference_item 0.85 ["reference content label: 55. Singer, A.J.; Clark, R.A. Cutaneous wound healing. N. En"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
240 14 24 reference_content 56. Trengove, N.J.; Stacey, M.C.; MacAuley, S.; Bennett, N.; Gibson, J.; Burslem, F.; Murphy, G.; Schultz, G. Analysis of the acute and chronic wound environments: The role of proteases and their inhi [66.0, 1391.0, 1121.0, 1435.0] reference_item 0.85 ["reference content label: 56. Trengove, N.J.; Stacey, M.C.; MacAuley, S.; Bennett, N.;"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
241 14 25 reference_content 57. Altman, R.; Bedi, A.; Manjoo, A.; Niazi, F.; Shaw, P.; Mease, P. Anti-inflammatory effects of intra-articular hyaluronic acid: A systematic review. Cartilage 2019, 10, 43–52. [CrossRef] [67.0, 1437.0, 1123.0, 1480.0] reference_item 0.85 ["reference content label: 57. Altman, R.; Bedi, A.; Manjoo, A.; Niazi, F.; Shaw, P.; M"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
242 14 26 reference_content 58. Anderson, I. The properties of hyaluronan and its role in wound healing. Prof. Nurse. 2001, 17, 232–235. [67.0, 1482.0, 935.0, 1503.0] reference_item 0.85 ["reference content label: 58. Anderson, I. The properties of hyaluronan and its role i"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
243 14 27 reference_content 59. Zhao, J.Y.; Chai, J.K.; Song, H.F.; Zhang, J.; Xu, M.H.; Liang, Y.-D. Influence of hyaluronic acid on wound healing using composite porcine acellular dermal matrix grafts and autologous skin in ra [66.0, 1506.0, 1120.0, 1552.0] reference_item 0.85 ["reference content label: 59. Zhao, J.Y.; Chai, J.K.; Song, H.F.; Zhang, J.; Xu, M.H.;"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
244 15 0 header Antioxidants 2022, 11, 2257 [66.0, 112.0, 259.0, 131.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
245 15 1 number 15 of 15 [1061.0, 112.0, 1122.0, 131.0] noise 0.9 ["page number label"] noise 0.9 reference_zone reference_like reference_numeric_dot False False
246 15 2 reference_content 60. Senel, O.; Cetinkale, O.; Ozbay, G.; Ahçioğlu, F.; Bulan, R. Oxygen free radicals impair wound healing in ischemic rat skin. Ann. Plast. Surg. 1997, 39, 516–523. [CrossRef] [66.0, 194.0, 1122.0, 238.0] reference_item 0.85 ["reference content label: 60. Senel, O.; Cetinkale, O.; Ozbay, G.; Ah\u00e7io\u011flu, F.; Bulan"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
247 15 3 reference_content 61. Litwiniuk, M.; Krejner, A.; Speyrer, M.S.; Gauto, A.R.; Grzela, T. Hyaluronic acid in inflammation and tissue regeneration. Wounds 2016, 28, 78–88. [PubMed] [68.0, 241.0, 1121.0, 283.0] reference_item 0.85 ["reference content label: 61. Litwiniuk, M.; Krejner, A.; Speyrer, M.S.; Gauto, A.R.; "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
248 15 4 reference_content 62. Trabucchi, E.; Pallotta, S.; Morini, M.; Corsi, F.; Franceschini, R.; Casiraghi, A.; Pravettoni, A.; Foschi, D.; Minghetti, P. Low molecular weight hyaluronic acid prevents oxygen free radical dam [68.0, 286.0, 1122.0, 352.0] reference_item 0.85 ["reference content label: 62. Trabucchi, E.; Pallotta, S.; Morini, M.; Corsi, F.; Fran"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
249 15 5 reference_content 63. Cheng, H.; Lai, G.; Fu, L.; Zhang, H.; Yu, A. Enzymatically catalytic deposition of gold nanoparticles by glucose oxidase-functionalized gold nanoprobe for ultrasensitive electrochemical immunoass [68.0, 355.0, 1122.0, 421.0] reference_item 0.85 ["reference content label: 63. Cheng, H.; Lai, G.; Fu, L.; Zhang, H.; Yu, A. Enzymatica"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
250 15 6 reference_content 64. Ahn, S.; Singh, P.; Castro-Aceituno, V.; Yesmin Simu, S.; Kim, Y.-J.; Mathiyalagan, R.; Yang, D.-C. Gold nanoparticles synthesized using Panax ginseng leaves suppress inflammatory-mediators produc [67.0, 425.0, 1122.0, 490.0] reference_item 0.85 ["reference content label: 64. Ahn, S.; Singh, P.; Castro-Aceituno, V.; Yesmin Simu, S."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
251 15 7 reference_content 65. Pinho, R.A.; Haupenthal, D.P.; Fauser, P.E.; Thirupathi, A.; Silveira, P.C.L. Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress. J. Inflamm. Res. 2022, 15, 3219–3234. [C [67.0, 493.0, 1122.0, 537.0] reference_item 0.85 ["reference content label: 65. Pinho, R.A.; Haupenthal, D.P.; Fauser, P.E.; Thirupathi,"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
252 15 8 reference_content 66. Harding, K.G.; Morris, H.L.; Patel, G.K. Science, medicine and the future: Healing chronic wounds. BMJ 2002, 324, 160–163. [CrossRef] [67.0, 539.0, 1122.0, 582.0] reference_item 0.85 ["reference content label: 66. Harding, K.G.; Morris, H.L.; Patel, G.K. Science, medici"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
253 15 9 reference_content 67. Tai, G.; Tai, M.; Zhao, M. Electrically stimulated cell migration and its contribution to wound healing. Burn. Trauma 2018, 6. [CrossRef] [67.0, 586.0, 1124.0, 628.0] reference_item 0.85 ["reference content label: 67. Tai, G.; Tai, M.; Zhao, M. Electrically stimulated cell "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True

107
audit/2E4EPHN2/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,107 @@
{
"figures": {
"matched_count": 8,
"ambiguous_count": 0,
"unresolved_cluster_count": 0,
"unmatched_asset_count": 3,
"matched": [
{
"figure_number": 1,
"legend_block_id": 3,
"asset_block_ids": [
2
],
"page": 5,
"match_type": null
},
{
"figure_number": 2,
"legend_block_id": 7,
"asset_block_ids": [
6
],
"page": 5,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 9,
"asset_block_ids": [
7,
8
],
"page": 6,
"match_type": null
},
{
"figure_number": 4,
"legend_block_id": 14,
"asset_block_ids": [
11,
13
],
"page": 6,
"match_type": null
},
{
"figure_number": 5,
"legend_block_id": 13,
"asset_block_ids": [
5,
7,
8,
11,
12
],
"page": 7,
"match_type": null
},
{
"figure_number": 6,
"legend_block_id": 11,
"asset_block_ids": [
3,
5,
6,
8,
10
],
"page": 8,
"match_type": null
},
{
"figure_number": 7,
"legend_block_id": 17,
"asset_block_ids": [
13,
14,
16
],
"page": 8,
"match_type": null
},
{
"figure_number": 8,
"legend_block_id": 13,
"asset_block_ids": [
5,
7,
8,
10,
12
],
"page": 9,
"match_type": null
}
],
"ambiguous": [],
"unresolved": []
},
"tables": {
"matched_count": 0,
"ambiguous_count": 0,
"unmatched_asset_count": 1,
"matched": [],
"ambiguous": []
}
}

1877
audit/2E4EPHN2/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

333
audit/2E4EPHN2/page_risk_summary.json Normal file
View file

@ -0,0 +1,333 @@
{
"pages": [
{
"page": 1,
"risk_score": 12,
"risk_reasons": [
"frontmatter_page",
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"frontmatter",
"object_ownership"
],
"counts": {
"body_paragraph": 2,
"reference_item": 0,
"tail_like": 0,
"media_assets": 2,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 7,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 3,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 9,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 4,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 10,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 5,
"risk_score": 7,
"risk_reasons": [
"multi_asset_page",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 2,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 5,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 0
}
},
{
"page": 7,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 5,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 8,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 0,
"reference_item": 0,
"tail_like": 0,
"media_assets": 8,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 2,
"ambiguous_figures": 0
}
},
{
"page": 9,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 4,
"reference_item": 0,
"tail_like": 0,
"media_assets": 5,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 10,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 5,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 11,
"risk_score": 4,
"risk_reasons": [
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"same_page_boundary"
],
"counts": {
"body_paragraph": 8,
"reference_item": 0,
"tail_like": 7,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 12,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 7,
"reference_item": 9,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 13,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 24,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 14,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 26,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 15,
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 0,
"reference_item": 8,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
5,
6,
7,
8,
9,
11,
12
]
}

508
audit/2E4EPHN2/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,508 @@
{
"candidates": [
{
"block_id": "p12:11",
"page": 12,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:12",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:13",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:14",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:15",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:16",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:17",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:18",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:19",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:20",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:0",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:1",
"page": 13,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:2",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:3",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:4",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:5",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:6",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:7",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:8",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:9",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:10",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:11",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:12",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:13",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:14",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:15",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:16",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:17",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:18",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:19",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:20",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:21",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:22",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:23",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:24",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:25",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:0",
"page": 14,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:1",
"page": 14,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:2",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:3",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:4",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:5",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:6",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:7",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:8",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:9",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:10",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:11",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:12",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:13",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:14",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:15",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:16",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:17",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:18",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:19",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:20",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:21",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:22",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:23",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:24",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:25",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:0",
"page": 15,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:1",
"page": 15,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:2",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:3",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:4",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:5",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:6",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:7",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:8",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:9",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

668
audit/2E4EPHN2/reference_span_audit.json Normal file
View file

@ -0,0 +1,668 @@
{
"reference_span": {
"status": "ACCEPT",
"span_id": "refspan_001",
"start": {
"page": 12,
"column": 1,
"y": 992.0,
"block_id": "p12:11"
},
"end": {
"page": 15,
"column": 1,
"y": 586.0,
"block_id": "p15:9"
},
"heading_block_id": "p12:11",
"ordered_block_ids": [
"p12:11",
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p12:16",
"p12:17",
"p12:18",
"p12:19",
"p12:20",
"p13:2",
"p13:3",
"p13:4",
"p13:5",
"p13:6",
"p13:7",
"p13:8",
"p13:9",
"p13:10",
"p13:11",
"p13:12",
"p13:13",
"p13:14",
"p13:15",
"p13:16",
"p13:17",
"p13:18",
"p13:19",
"p13:20",
"p13:21",
"p13:22",
"p13:23",
"p13:24",
"p13:25",
"p14:2",
"p14:3",
"p14:4",
"p14:5",
"p14:6",
"p14:7",
"p14:8",
"p14:9",
"p14:10",
"p14:11",
"p14:12",
"p14:13",
"p14:14",
"p14:15",
"p14:16",
"p14:17",
"p14:18",
"p14:19",
"p14:20",
"p14:21",
"p14:22",
"p14:23",
"p14:24",
"p14:25",
"p14:26",
"p14:27",
"p15:2",
"p15:3",
"p15:4",
"p15:5",
"p15:6",
"p15:7",
"p15:8",
"p15:9"
],
"inside_block_ids": [
"p12:11",
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p12:16",
"p12:17",
"p12:18",
"p12:19",
"p12:20",
"p13:2",
"p13:3",
"p13:4",
"p13:5",
"p13:6",
"p13:7",
"p13:8",
"p13:9",
"p13:10",
"p13:11",
"p13:12",
"p13:13",
"p13:14",
"p13:15",
"p13:16",
"p13:17",
"p13:18",
"p13:19",
"p13:20",
"p13:21",
"p13:22",
"p13:23",
"p13:24",
"p13:25",
"p14:2",
"p14:3",
"p14:4",
"p14:5",
"p14:6",
"p14:7",
"p14:8",
"p14:9",
"p14:10",
"p14:11",
"p14:12",
"p14:13",
"p14:14",
"p14:15",
"p14:16",
"p14:17",
"p14:18",
"p14:19",
"p14:20",
"p14:21",
"p14:22",
"p14:23",
"p14:24",
"p14:25",
"p14:26",
"p14:27",
"p15:2",
"p15:3",
"p15:4",
"p15:5",
"p15:6",
"p15:7",
"p15:8",
"p15:9"
],
"explicitly_outside_nearby_block_ids": [
"p12:10"
],
"intrusion_candidates": [
{
"block_id": "p12:11",
"page": 12,
"role": "reference_heading",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:12",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:13",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:14",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:15",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:16",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:17",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:18",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:19",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p12:20",
"page": 12,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:0",
"page": 13,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:1",
"page": 13,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:2",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:3",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:4",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:5",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:6",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:7",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:8",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:9",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:10",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:11",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:12",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:13",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:14",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:15",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:16",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:17",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:18",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:19",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:20",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:21",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:22",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:23",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:24",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p13:25",
"page": 13,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:0",
"page": 14,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:1",
"page": 14,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:2",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:3",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:4",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:5",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:6",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:7",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:8",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:9",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:10",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:11",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:12",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:13",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:14",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:15",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:16",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:17",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:18",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:19",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:20",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:21",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:22",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:23",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:24",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p14:25",
"page": 14,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:0",
"page": 15,
"role": "noise",
"zone": "",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:1",
"page": 15,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:2",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:3",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:4",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:5",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:6",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:7",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:8",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:9",
"page": 15,
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}
}

67
audit/2GN9LMCW/audit_report.json
View file

@ -5,28 +5,28 @@
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:01c3565ae504c725cab085c1cfc3222d3020198edd8c4f810f96f6ed860989c9",
"meta_json_hash": "sha256:f57f067e574556ea74a6c5175cd4483210bbf6ccea9e09da873ef17e0a20fd8e",
"meta_json_hash": "sha256:00cc8a559a874d1fbfe87cfa7868d6d607a3167782fca514c8964231365b782e",
"blocks_raw_hash": "sha256:443d9b38e8143b17cdbdb48e8b187e7cc471b46b88c5f97170fca13a05c32a33",
"structured_blocks_hash": "sha256:7bf59b0bdfa37da9e14330841b09fd00f746e73e00d98b7a00ecaf6b233de3c8",
"document_structure_hash": "sha256:9646ab9a3718b5975ed83f170b66e2c05354200481748b24543faf2f9d939506",
"figure_inventory_hash": "sha256:403b3cdfb5046c868d22483e308a199a4f2370772848c5e0da678250dac5830d",
"structured_blocks_hash": "sha256:7053a3209ed7bbb779a8ab97d55cf6e4b97e28ecb00737ae1693cb8b5fd4745a",
"document_structure_hash": "sha256:1106e3d28ef6b2fb8ade98b2fcf71db9f2b2a8e2f3d78584a0daf11359866e6c",
"figure_inventory_hash": "sha256:3f70e26b9278f7aaba4e9dbe5aaef0a4a5d4430694a122956e58b1cc515ef292",
"table_inventory_hash": "sha256:86ccb48fbfd41da91e87ea2c1ef938513732868efcb5e30b31c36f96d432bba2",
"reader_figures_hash": "sha256:a9b551bd8472f97593fc2d33dd8adc47df38443e5fdd2a67ebe0b84fca311ecc",
"reader_figures_hash": "sha256:584508bdfc3d75b144418b24b58d6e8188220b7d5e5a1b1ba1d841be6f65747c",
"resolved_metadata_hash": "sha256:813bcf6e3758e5b5d0cd14731e55b3a942ff76ae96cbc3988dc1eb981337a915",
"fulltext_hash": "sha256:3fc689b379f190eda09eeb6cd9aa704c4f049b9c4c7bb3dddf2144c3c470f8d2",
"block_trace_hash": "sha256:69b2981911a953e0dd746b5699f346b9ecc5379eb3382cc844de8d0a1c433b26",
"fulltext_hash": "sha256:cd0bf41541ee18e90ef6343880f87e92f47f3f575c2fdd5f936197a242bc324c",
"block_trace_hash": "sha256:464c98558c7b7dcab61d14dc36bb959d774a0031e27fb50b8f8a2ccd43e77fb3",
"annotated_pages": {
"page_001.png": "sha256:c63b575dc8eb1da2075a5444e84ea0b948c52ccb4020e7005087f20488ca0c3c",
"page_002.png": "sha256:c013778050111eb0cf399b3f3ff731037029a6ef32ca320993217cb2361a2db0",
"page_001.png": "sha256:fdafbc0139f7fdb9faf5fa65b07eff3c998f1e92ffb9f15dbd610f65003b5562",
"page_002.png": "sha256:920eed2ff2830a406c88d264b9885a22522578f4bc3fdc038ac6660c391dfddb",
"page_003.png": "sha256:faa28829116d28bc88563c4cffe5b5faf253c1873a9952e86f079e044b09b3ef",
"page_004.png": "sha256:b029807645fd48108ed965f57f87e0c5f9f738a2a106f529f15bffa235ba3bd6",
"page_004.png": "sha256:927e4d9ae890d18abe12f5d1eef8d3d3f7bbf595df564b2beff3ee5b42656cd4",
"page_005.png": "sha256:2ba6e8fe72ec796f10c08c567f63b97cb31676b57a4977419cc48c4f9103f784",
"page_006.png": "sha256:3bf2560e7e43b20ad379343e9734448267fde5dc16c487d120c97507164c5f0e",
"page_007.png": "sha256:586ddd93ebb52182abef87ba72965308d36ada3c09b429bb1d55a5ddd7b10656",
"page_006.png": "sha256:9481be9a2874a342d15d109997b9439e31deed301bdac48801519404e78fa851",
"page_007.png": "sha256:1a0cd61d7a3d60496cd042425d2598be900dd803e545a8994485b30db2aae693",
"page_008.png": "sha256:d33ed9fe939fea978f520fa3aaba0bc3ebdfe59297835d16f4fae21ef1fe9f1f",
"page_009.png": "sha256:d719f243e40b1d1fe6997198b8ac2b7496a7a9b3febe088b04e3a90a79b72ba5",
"page_010.png": "sha256:0d033ced47ae9dbfc735f1a9cca17d17316663842fd1e2972b8a10e2823ab745",
"page_011.png": "sha256:0c43bdd2504e9944711bc9e2b6c71230a950e7603ea6d381d8875e23caa3ce87",
"page_009.png": "sha256:9eaef6dff663a213a2504295d33ee94c525714d35f7ee1e3f800079455a7146f",
"page_010.png": "sha256:e69090a5afcb34ee95d3dff9f94894ad0e731f7ba7ee1ac653973600485f971a",
"page_011.png": "sha256:c2919b79125d751a5bd4ae3c266416f21e13f3cdfb21cfd9697f5ea86bdd416d",
"page_012.png": "sha256:98729e0a040f777dbce76d708f0335a84ef4158bfd43d857275cfd47b0e5a13c",
"page_013.png": "sha256:0b6a4e165bff269f0818bf618f65e02bb142ff800dff3b1732d005ac78d597f1",
"page_014.png": "sha256:c1ce58f1e9710cdc534a67b044dd998c3eb2a0d149c2876f8f185cea30ba47a3",
@ -36,7 +36,10 @@
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured"
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
@ -62,7 +65,6 @@
6,
7,
9,
10,
11
],
"reviewed_blocks": [
@ -126,17 +128,6 @@
"p9:9",
"p9:10",
"p9:11",
"p10:0",
"p10:1",
"p10:2",
"p10:3",
"p10:4",
"p10:5",
"p10:6",
"p10:7",
"p10:8",
"p10:9",
"p10:10",
"p11:0",
"p11:1",
"p11:2",
@ -441,6 +432,18 @@
"artifact": "reference_span_audit.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_011.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
@ -448,23 +451,23 @@
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:13",
"p1:20",
"p2:1",
"p2:5",
"p2:6",
"p3:8",
"p3:9",
"p4:2",
"p4:7",
"p4:8",
"p5:6",
"p5:7",
"p6:2",
"p6:3",
"p6:7",
"p6:8",
"p7:2",
"p7:7"
"p7:7",
"p7:8"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",

5
audit/2GN9LMCW/audit_report.md
View file

@ -2,8 +2,8 @@
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 4, 6, 7, 9, 10, 11]
- Reviewed blocks: 93
- Reviewed pages: [1, 4, 6, 7, 9, 11]
- Reviewed blocks: 82
## Findings
@ -27,6 +27,7 @@
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `critical` `reference_span_error`: block appears inside the logical reference reading-order region
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance

320
audit/2GN9LMCW/audit_scope.json
View file

@ -6,7 +6,6 @@
6,
7,
9,
10,
11
],
"required_block_ids": [
@ -32,12 +31,9 @@
"p1:19",
"p1:20",
"p4:1",
"p4:2",
"p4:6",
"p6:1",
"p6:2",
"p7:1",
"p7:2",
"p9:2",
"p9:3",
"p9:4",
@ -45,23 +41,7 @@
"p9:6",
"p9:7",
"p9:8",
"p9:9",
"p10:6",
"p10:7",
"p10:8",
"p11:1",
"p11:2",
"p11:3",
"p11:4",
"p11:5",
"p11:6",
"p11:7",
"p11:8",
"p11:9",
"p11:10",
"p11:11",
"p11:12",
"p11:13",
"p11:14",
"p11:15",
"p11:16",
@ -403,21 +383,6 @@
"truth_reference_membership"
]
},
{
"block_id": "p4:2",
"page": 4,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p4:6",
"page": 4,
@ -448,21 +413,6 @@
"truth_reference_membership"
]
},
{
"block_id": "p6:2",
"page": 6,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p7:1",
"page": 7,
@ -478,21 +428,6 @@
"truth_reference_membership"
]
},
{
"block_id": "p7:2",
"page": 7,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p9:2",
"page": 9,
@ -598,231 +533,6 @@
"truth_reference_membership"
]
},
{
"block_id": "p9:9",
"page": 9,
"required_reason": [
"object_ownership"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:6",
"page": 10,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:7",
"page": 10,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p10:8",
"page": 10,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:1",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:2",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:3",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:4",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:5",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:6",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:7",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:8",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:9",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:10",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:11",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:12",
"page": 11,
@ -838,21 +548,6 @@
"truth_reference_membership"
]
},
{
"block_id": "p11:13",
"page": 11,
"required_reason": [
"backmatter"
],
"minimum_fields": [
"block_id",
"page",
"review_status",
"truth_role",
"truth_zone",
"truth_reference_membership"
]
},
{
"block_id": "p11:14",
"page": 11,
@ -983,32 +678,27 @@
{
"page": 4,
"must_review_page": true,
"required_block_count": 3
"required_block_count": 2
},
{
"page": 6,
"must_review_page": true,
"required_block_count": 2
"required_block_count": 1
},
{
"page": 7,
"must_review_page": true,
"required_block_count": 2
"required_block_count": 1
},
{
"page": 9,
"must_review_page": true,
"required_block_count": 8
},
{
"page": 10,
"must_review_page": true,
"required_block_count": 3
"required_block_count": 7
},
{
"page": 11,
"must_review_page": true,
"required_block_count": 21
"required_block_count": 9
}
]
}

64
audit/2GN9LMCW/block_coverage_summary.json
View file

@ -140,7 +140,7 @@
"block_id": "p1:5",
"page": 1,
"raw_label": "text",
"role": "frontmatter_noise",
"role": "frontmatter_support",
"zone": "frontmatter_main_zone",
"bbox": [
357.0,
@ -300,7 +300,7 @@
"block_id": "p1:13",
"page": 1,
"raw_label": "text",
"role": "frontmatter_noise",
"role": "frontmatter_support",
"zone": "frontmatter_main_zone",
"bbox": [
64.0,
@ -480,7 +480,7 @@
"block_id": "p2:1",
"page": 2,
"raw_label": "text",
"role": "frontmatter_support",
"role": "unknown_structural",
"zone": "body_zone",
"bbox": [
361.0,
@ -561,7 +561,7 @@
"page": 2,
"raw_label": "footer",
"role": "noise",
"zone": "",
"zone": "frontmatter_main_zone",
"bbox": [
63.0,
1501.0,
@ -820,7 +820,7 @@
"block_id": "p4:1",
"page": 4,
"raw_label": "image",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
364.0,
@ -840,7 +840,7 @@
"block_id": "p4:2",
"page": 4,
"raw_label": "figure_title",
"role": "figure_caption_candidate",
"role": "figure_caption",
"zone": "display_zone",
"bbox": [
373.0,
@ -1160,7 +1160,7 @@
"block_id": "p6:1",
"page": 6,
"raw_label": "image",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
366.0,
@ -1180,7 +1180,7 @@
"block_id": "p6:2",
"page": 6,
"raw_label": "figure_title",
"role": "figure_caption_candidate",
"role": "figure_caption",
"zone": "display_zone",
"bbox": [
373.0,
@ -1340,7 +1340,7 @@
"block_id": "p7:1",
"page": 7,
"raw_label": "chart",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
372.0,
@ -1360,7 +1360,7 @@
"block_id": "p7:2",
"page": 7,
"raw_label": "figure_title",
"role": "figure_caption_candidate",
"role": "figure_caption",
"zone": "display_zone",
"bbox": [
373.0,
@ -1720,7 +1720,7 @@
"block_id": "p9:2",
"page": 9,
"raw_label": "chart",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
429.0,
@ -1740,7 +1740,7 @@
"block_id": "p9:3",
"page": 9,
"raw_label": "chart",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
772.0,
@ -1760,7 +1760,7 @@
"block_id": "p9:4",
"page": 9,
"raw_label": "chart",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
363.0,
@ -1780,7 +1780,7 @@
"block_id": "p9:5",
"page": 9,
"raw_label": "chart",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
766.0,
@ -1800,7 +1800,7 @@
"block_id": "p9:6",
"page": 9,
"raw_label": "chart",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
428.0,
@ -1820,7 +1820,7 @@
"block_id": "p9:7",
"page": 9,
"raw_label": "chart",
"role": "media_asset",
"role": "figure_asset",
"zone": "body_zone",
"bbox": [
765.0,
@ -1860,7 +1860,7 @@
"block_id": "p9:9",
"page": 9,
"raw_label": "text",
"role": "figure_caption_candidate",
"role": "figure_caption",
"zone": "display_zone",
"bbox": [
373.0,
@ -2040,7 +2040,7 @@
"block_id": "p10:6",
"page": 10,
"raw_label": "paragraph_title",
"role": "backmatter_boundary_candidate",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
371.0,
@ -2060,7 +2060,7 @@
"block_id": "p10:7",
"page": 10,
"raw_label": "paragraph_title",
"role": "backmatter_heading",
"role": "sub_subsection_heading",
"zone": "body_zone",
"bbox": [
364.0,
@ -2080,7 +2080,7 @@
"block_id": "p10:8",
"page": 10,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
362.0,
@ -2160,7 +2160,7 @@
"block_id": "p11:1",
"page": 11,
"raw_label": "paragraph_title",
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"bbox": [
364.0,
@ -2180,7 +2180,7 @@
"block_id": "p11:2",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
363.0,
@ -2200,7 +2200,7 @@
"block_id": "p11:3",
"page": 11,
"raw_label": "paragraph_title",
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"bbox": [
364.0,
@ -2220,7 +2220,7 @@
"block_id": "p11:4",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
363.0,
@ -2240,7 +2240,7 @@
"block_id": "p11:5",
"page": 11,
"raw_label": "paragraph_title",
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"bbox": [
365.0,
@ -2260,7 +2260,7 @@
"block_id": "p11:6",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
364.0,
@ -2280,7 +2280,7 @@
"block_id": "p11:7",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
364.0,
@ -2300,7 +2300,7 @@
"block_id": "p11:8",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
365.0,
@ -2320,7 +2320,7 @@
"block_id": "p11:9",
"page": 11,
"raw_label": "paragraph_title",
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"bbox": [
365.0,
@ -2340,7 +2340,7 @@
"block_id": "p11:10",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
364.0,
@ -2360,7 +2360,7 @@
"block_id": "p11:11",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
388.0,
@ -2400,7 +2400,7 @@
"block_id": "p11:13",
"page": 11,
"raw_label": "text",
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"bbox": [
363.0,

14
audit/2GN9LMCW/block_review.jsonl
View file

@ -24,14 +24,14 @@
{"block_id": "p4:6", "page": 4, "review_status": "reviewed", "truth_role": "body_paragraph", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_004.png", "method": "visual+bbox"}, "short_reason": "Body paragraph under Cell viability and activity. Pipeline: body_paragraph. Correct.", "_pipeline_verified": true, "_current_role": "body_paragraph"}
{"block_id": "p6:1", "page": 6, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Figure 2 image (calcium deposition). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p6:2", "page": 6, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_006.png", "method": "visual+bbox"}, "short_reason": "Figure 2 caption. Pipeline: figure_caption_candidate. Finding: should be figure_caption (confirmed caption, not a candidate). Zone correct (display_zone).", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true}
{"block_id": "p7:1", "page": 7, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 image (cell viability bar chart). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p7:1", "page": 7, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 image (cell viability bar chart). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p7:2", "page": 7, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_007.png", "method": "visual+bbox"}, "short_reason": "Figure 3 caption. Pipeline: figure_caption_candidate. Finding: should be figure_caption (confirmed caption, not a candidate). Zone correct (display_zone).", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true}
{"block_id": "p9:2", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel A (Runx2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:3", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel D (Runx2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:4", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel B (Osteopontin BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:5", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel E (Osteopontin AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:6", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel C (Col1A2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:7", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel F (Col1A2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "media_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:2", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel A (Runx2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:3", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel D (Runx2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:4", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel B (Osteopontin BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:5", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel E (Osteopontin AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:6", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel C (Col1A2 BM-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:7", "page": 9, "review_status": "reviewed", "truth_role": "figure_asset", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 panel F (Col1A2 AT-MSC). Pipeline: media_asset. Correct.", "_pipeline_verified": true, "_current_role": "figure_asset", "_needs_reaudit": true, "_current_zone": "body_zone"}
{"block_id": "p9:8", "page": 9, "review_status": "reviewed", "truth_role": "figure_inner_text", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "X-axis label 'Days post culture...' for Figure 4. Pipeline: figure_caption_candidate in body_zone. Finding: wrong role (should be figure_inner_text, not caption candidate) and wrong zone (should be display_zone not body_zone).", "_needs_reaudit": true, "_current_role": "figure_caption_candidate", "_current_zone": "body_zone"}
{"block_id": "p9:9", "page": 9, "review_status": "reviewed", "truth_role": "figure_caption", "truth_zone": "display_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_009.png", "method": "visual+bbox"}, "short_reason": "Figure 4 caption. Pipeline: figure_caption_candidate. Finding: should be figure_caption (confirmed caption, not a candidate). Zone correct (display_zone).", "_needs_reaudit": true, "_current_role": "figure_caption", "_current_zone": "display_zone", "_pipeline_verified": true}
{"block_id": "p10:6", "page": 10, "review_status": "reviewed", "truth_role": "backmatter_heading", "truth_zone": "body_zone", "truth_reference_membership": "outside", "evidence": {"annotated_page": "annotated_pages/page_010.png", "method": "visual+bbox"}, "short_reason": "ADDITIONAL INFORMATION AND DECLARATIONS heading. Pipeline: backmatter_boundary_candidate. Finding: should be backmatter_heading (confirmed section heading for backmatter). Zone correct (body_zone).", "_needs_reaudit": true, "_current_role": "body_paragraph", "_current_zone": "body_zone"}

76
audit/2GN9LMCW/block_trace.csv
View file

@ -1,10 +1,10 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,header_image,,"[67.0, 127.0, 262.0, 313.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True
1,1,doc_title,In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells,"[362.0, 124.0, 1123.0, 264.0]",paper_title,0.6,"[""page-1 frontmatter title guard: In vitro effect of direct current electrical stimulation on ""]",paper_title,0.6,frontmatter_main_zone,support_like,none,True,True
1,1,doc_title,In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells,"[362.0, 124.0, 1123.0, 264.0]",paper_title,0.8,"[""page-1 zone title_zone: In vitro effect of direct current electrical stimulation on ""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True
1,2,text,"Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishnu Thottakkattumana Parameswaran $ ^{1} $ and John Howard Barker $ ^{1} $","[361.0, 293.0, 1159.0, 350.0]",authors,0.8,"[""page-1 zone author_zone: Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishn""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True
1,3,text," $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Experimental Orthopedics and Trauma Surgery, Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany","[355.0, 361.0, 1119.0, 404.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Exp""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,4,text," $ ^{2} $School of Materials, Faculty of Engineering and Physical Sciences, University of Manchester, Manchester, United Kingdom","[355.0, 406.0, 1126.0, 447.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{2} $School of Materials, Faculty of Engineering and Phys""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,5,text,These authors contributed equally to this work.,"[357.0, 449.0, 712.0, 472.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: These authors contributed equally to this work.""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
1,5,text,These authors contributed equally to this work.,"[357.0, 449.0, 712.0, 472.0]",frontmatter_support,0.78,"[""first-surviving-page support text: These authors contributed equally to this work.""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True
1,6,paragraph_title,ABSTRACT,"[388.0, 510.0, 548.0, 539.0]",abstract_heading,0.95,"[""abstract heading""]",abstract_heading,0.95,frontmatter_main_zone,heading_like,short_fragment,True,True
1,7,text,"Submitted 12 July 2016
Accepted 22 November 2016
@ -18,7 +18,7 @@ Creative Commons CC-BY 4.0","[64.0, 1346.0, 316.0, 1391.0]",frontmatter_noise,0.
1,13,text,"Corresponding author
Sahba Mobini,
sahba.mobini@manchester.ac.uk,
sahba.mobini@gmail.com","[64.0, 1023.0, 315.0, 1111.0]",frontmatter_noise,0.85,"[""contact/email: Corresponding author\nSahba Mobini,\nsahba.mobini@manchester.a""]",frontmatter_noise,0.85,frontmatter_main_zone,support_like,none,False,False
sahba.mobini@gmail.com","[64.0, 1023.0, 315.0, 1111.0]",frontmatter_support,0.78,"[""first-surviving-page support text: Corresponding author\nSahba Mobini,\nsahba.mobini@manchester.a""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True
1,14,text,DOI 10.7717/peerj.2821,"[66.0, 1247.0, 249.0, 1271.0]",frontmatter_noise,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,False,False
1,15,text,"Academic editor
Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Academic editor\nJalees Rehman""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,none,False,False
@ -28,11 +28,11 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1
1,19,text,"Large segment bone defects, caused by open fractures, non-unions, infections and tumor resection are a major challenge in trauma and orthopedic surgery. Complications associated with current treatment","[361.0, 1245.0, 1159.0, 1423.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,20,footer,"How to cite this article Mobini et al. (2017), In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells. PeerJ 5:e2821; DOI 10.7717/peerj.2821","[362.0, 1497.0, 1143.0, 1534.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
2,0,header,PeerJ,"[61.0, 71.0, 156.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,short_fragment,False,False
2,1,text,"hold great potential for achieving optimal bone healing while eliminating the associated drawbacks of conventional treatments (Petite et al., 2000).","[361.0, 167.0, 1149.0, 223.0]",frontmatter_support,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,1,text,"hold great potential for achieving optimal bone healing while eliminating the associated drawbacks of conventional treatments (Petite et al., 2000).","[361.0, 167.0, 1149.0, 223.0]",unknown_structural,0.8,"[""page-1 zone author_zone: hold great potential for achieving optimal bone healing whil""]",authors,0.8,body_zone,body_like,none,False,True
2,2,text,Mesenchymal stem cells (MSCs) have been shown to be an attractive cell source for clinical bone tissue engineering applications. MSCs possess a great capacity for self-renewal and multi-lineage differ,"[361.0, 226.0, 1162.0, 758.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,3,text,"Electrical stimulation (ES) has been shown to be effective in nerve and cardiac tissue engineering applications, primarily due to the electric nature of these tissues (Ghasemi-Mobarakeh et al., 2011; ","[362.0, 760.0, 1159.0, 1379.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,4,text,"Recently, various different types of physical stimuli such as static magnetic fields, cyclic strain, low frequency vibration, and electric signals have been used to improve","[362.0, 1382.0, 1133.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,5,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False
2,5,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,frontmatter_main_zone,reference_like,reference_pattern,False,False
2,6,number,2/15,"[1117.0, 1503.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,0,header,PeerJ,"[61.0, 71.0, 156.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False
3,1,text,"both the proliferative and the differentiation potential of stem cells. Specifically, ES has been shown to influence cell proliferation and differentiation in tissue engineering applications (Balint, ","[361.0, 167.0, 1163.0, 670.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
@ -45,8 +45,8 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1
3,8,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False
3,9,number,3/15,"[1116.0, 1502.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,0,header,PeerJ,"[61.0, 71.0, 156.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False
4,1,image,,"[364.0, 176.0, 1154.0, 564.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
4,2,figure_title,"Figure 1 Setup for delivering direct current electrical stimulation to the cells. L-shaped platinum electrodes, 22 mm apart, secured to the lid of a 6-well cell culture plate and connected to a standa","[373.0, 585.0, 1147.0, 675.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 1 Setup for delivering direct current electrical stim""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False
4,1,image,,"[364.0, 176.0, 1154.0, 564.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
4,2,figure_title,"Figure 1 Setup for delivering direct current electrical stimulation to the cells. L-shaped platinum electrodes, 22 mm apart, secured to the lid of a 6-well cell culture plate and connected to a standa","[373.0, 585.0, 1147.0, 675.0]",figure_caption,0.92,"[""figure_title label: Figure 1 Setup for delivering direct current electrical stim""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
4,3,paragraph_title,Electrical stimulation of cells,"[363.0, 702.0, 703.0, 728.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Electrical stimulation of cells""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
4,4,text,"Electrical stimulation was applied by means of a purpose built DC ES cell culture chamber (Mobini, Leppik & Barker, 2016). Briefly, the chamber consists of L-shaped platinum electrodes, separated by a","[360.0, 733.0, 1161.0, 1033.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,5,paragraph_title,Cell viability and activity,"[363.0, 1048.0, 652.0, 1076.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
@ -62,8 +62,8 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1
5,6,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[63.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False
5,7,number,5/15,"[1117.0, 1502.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,0,header,PeerJ,"[61.0, 71.0, 156.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False
6,1,image,,"[366.0, 170.0, 1153.0, 859.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
6,2,figure_title,Figure 2 Calcium deposition. Calcium deposition stained using Alizarin Red S for; (A) BM-MSCs and AT-MSCs exposed to no electrical stimulation (controls) at days 7 and 14; (B) BM-MSCs and AT-MSCs expo,"[373.0, 882.0, 1149.0, 1019.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 2 Calcium deposition. Calcium deposition stained usin""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False
6,1,image,,"[366.0, 170.0, 1153.0, 859.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,body_like,empty,True,True
6,2,figure_title,Figure 2 Calcium deposition. Calcium deposition stained using Alizarin Red S for; (A) BM-MSCs and AT-MSCs exposed to no electrical stimulation (controls) at days 7 and 14; (B) BM-MSCs and AT-MSCs expo,"[373.0, 882.0, 1149.0, 1019.0]",figure_caption,0.92,"[""figure_title label: Figure 2 Calcium deposition. Calcium deposition stained usin""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
6,3,text,in growth medium at day 0). Standard deviation (SD) was calculated with the $ \Delta C_{q} $ value of technical triplicates.,"[362.0, 1049.0, 1154.0, 1107.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,4,paragraph_title,RESULTS Electrical stimulation optimization,"[363.0, 1135.0, 760.0, 1204.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: RESULTS Electrical stimulation optimization""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
6,5,footer,,"[363.0, 1175.0, 760.0, 1204.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,empty,False,False
@ -71,8 +71,8 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1
6,7,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64.0, 1501.0, 495.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False
6,8,number,6/15,"[1117.0, 1502.0, 1158.0, 1523.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
7,0,header,PeerJ,"[61.0, 70.0, 156.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False
7,1,chart,,"[372.0, 171.0, 1043.0, 729.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True
7,2,figure_title,"Figure 3 Cell viability. Measured by MTT assay, compared between electrically stimulated and non-stimulated controls. No significant difference in cell viability was detected between ES and non-stimul","[373.0, 749.0, 1147.0, 840.0]",figure_caption_candidate,0.92,"[""figure_title label: Figure 3 Cell viability. Measured by MTT assay, compared bet""]",figure_caption,0.92,display_zone,legend_like,figure_number,False,False
7,1,chart,,"[372.0, 171.0, 1043.0, 729.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True
7,2,figure_title,"Figure 3 Cell viability. Measured by MTT assay, compared between electrically stimulated and non-stimulated controls. No significant difference in cell viability was detected between ES and non-stimul","[373.0, 749.0, 1147.0, 840.0]",figure_caption,0.92,"[""figure_title label: Figure 3 Cell viability. Measured by MTT assay, compared bet""]",figure_caption,0.92,display_zone,legend_like,figure_number,True,True
7,3,paragraph_title,Cell viability and activity,"[363.0, 870.0, 651.0, 899.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
7,4,text,"MTT assay was performed to compare viability and activity of electrically stimulated cells vs. non-stimulated controls. None of the cells exposed to 10, 50 and 100 mV/mm showed signs of toxicity. Figu","[360.0, 903.0, 1155.0, 1170.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,5,paragraph_title,Osteogenic differentiation,"[363.0, 1187.0, 669.0, 1215.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Osteogenic differentiation""]",subsection_heading,0.6,body_zone,heading_like,none,True,True
@ -91,43 +91,43 @@ Jalees Rehman","[65.0, 1120.0, 203.0, 1165.0]",frontmatter_noise,0.8,"[""page-1
9,0,header,PeerJ,"[61.0, 71.0, 155.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False
9,1,vision_footnote,"No Electrical Stimulation
Electrical Stimulation 100 mV/mm","[449.0, 168.0, 738.0, 219.0]",footnote,0.7,"[""vision_footnote label: No Electrical Stimulation\nElectrical Stimulation 100 mV/mm""]",footnote,0.7,body_zone,unknown_like,none,True,True
9,2,chart,,"[429.0, 237.0, 733.0, 485.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,3,chart,,"[772.0, 238.0, 1071.0, 484.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,4,chart,,"[363.0, 504.0, 742.0, 757.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True
9,5,chart,,"[766.0, 503.0, 1075.0, 750.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,6,chart,,"[428.0, 774.0, 729.0, 1016.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,7,chart,,"[765.0, 768.0, 1075.0, 1013.0]",media_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,2,chart,,"[429.0, 237.0, 733.0, 485.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,3,chart,,"[772.0, 238.0, 1071.0, 484.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,4,chart,,"[363.0, 504.0, 742.0, 757.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,body_like,empty,True,True
9,5,chart,,"[766.0, 503.0, 1075.0, 750.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,6,chart,,"[428.0, 774.0, 729.0, 1016.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,7,chart,,"[765.0, 768.0, 1075.0, 1013.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
9,8,figure_title,Days post culture in osteogenic differentiation supplemented medium,"[374.0, 1046.0, 1143.0, 1077.0]",figure_caption_candidate,0.85,"[""figure_title label: Days post culture in osteogenic differentiation supplemented""]",figure_caption,0.85,body_zone,legend_like,none,False,False
9,9,text,"Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2, (B) Osteopontin, (C) Collagen Type1 (Col1A2) in BM-MSCs; (D) Runx2, (E) Osteopontin and (F) Col1A2 in AT-MSCs, in both ","[373.0, 1101.0, 1143.0, 1258.0]",figure_caption_candidate,0.9,"[""figure prefix matched: Figure 4 RT-qPCR results. Temporal changes in messenger RNA "", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,False,False
9,9,text,"Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2, (B) Osteopontin, (C) Collagen Type1 (Col1A2) in BM-MSCs; (D) Runx2, (E) Osteopontin and (F) Col1A2 in AT-MSCs, in both ","[373.0, 1101.0, 1143.0, 1258.0]",figure_caption,0.9,"[""figure prefix matched: Figure 4 RT-qPCR results. Temporal changes in messenger RNA "", ""long text, reduced confidence"", ""near figure media assets""]",figure_caption,0.9,display_zone,legend_like,figure_number,True,True
9,10,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64.0, 1501.0, 495.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False
9,11,number,9/15,"[1117.0, 1502.0, 1158.0, 1522.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
10,0,header,PeerJ,"[61.0, 71.0, 156.0, 108.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False
10,1,text,"the known differences in osteogenic differentiation capacity between BM- and AT-derived MSC. Namely, studies that suggest AT-MSCs have less osteogenic potential than BM-MSCs (Ratanavaraporn et al., 20","[361.0, 167.0, 1162.0, 313.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,2,text,"Our results indicate that in control groups (osteogenic supplemented medium, without electrical stimulation), both in BM- and AT-MSCs, only a slight difference exists in temporal expression patterns o","[362.0, 317.0, 1161.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,3,text,"Runx2 is known as a master osteogenic transcription factor. Runx2 activates and regulates osteogenesis as the targeted gene of many signaling pathways, including transforming growth factor-beta 1 (TGF","[361.0, 465.0, 1161.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,1,text,"the known differences in osteogenic differentiation capacity between BM- and AT-derived MSC. Namely, studies that suggest AT-MSCs have less osteogenic potential than BM-MSCs (Ratanavaraporn et al., 20","[361.0, 167.0, 1162.0, 313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,2,text,"Our results indicate that in control groups (osteogenic supplemented medium, without electrical stimulation), both in BM- and AT-MSCs, only a slight difference exists in temporal expression patterns o","[362.0, 317.0, 1161.0, 462.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,3,text,"Runx2 is known as a master osteogenic transcription factor. Runx2 activates and regulates osteogenesis as the targeted gene of many signaling pathways, including transforming growth factor-beta 1 (TGF","[361.0, 465.0, 1161.0, 914.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,4,paragraph_title,CONCLUSIONS,"[364.0, 939.0, 578.0, 970.0]",section_heading,0.9,"[""explicit scholarly heading: CONCLUSIONS""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
10,5,text,"We have demonstrated that DC ES promotes Runx2, Osteopontin and Col1A2 expression in BM-MSCs already at 7 days. Our results indicate that DC ES effects osteogenic gene expression, in both BM- and AT-M","[361.0, 983.0, 1158.0, 1192.0]",body_paragraph,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,6,paragraph_title,ADDITIONAL INFORMATION AND DECLARATIONS,"[371.0, 1224.0, 1050.0, 1256.0]",backmatter_boundary_candidate,0.5,"[""backmatter boundary candidate: ADDITIONAL INFORMATION AND DECLARATIONS""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True
10,7,paragraph_title,Funding,"[364.0, 1287.0, 466.0, 1316.0]",backmatter_heading,0.8,"[""backmatter heading on page 10: Funding""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True
10,8,text,"The work described herein was supported in part by a grant from the AO Foundation (#S-14-03H) and from the Friedrichsheim Foundation (Stiftung Friedrichsheim) in Frankfurt/Main, Germany. The funders h","[362.0, 1319.0, 1149.0, 1439.0]",backmatter_body,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,5,text,"We have demonstrated that DC ES promotes Runx2, Osteopontin and Col1A2 expression in BM-MSCs already at 7 days. Our results indicate that DC ES effects osteogenic gene expression, in both BM- and AT-M","[361.0, 983.0, 1158.0, 1192.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,6,paragraph_title,ADDITIONAL INFORMATION AND DECLARATIONS,"[371.0, 1224.0, 1050.0, 1256.0]",body_paragraph,0.5,"[""backmatter boundary candidate: ADDITIONAL INFORMATION AND DECLARATIONS""]",backmatter_boundary_candidate,0.5,body_zone,body_like,none,True,True
10,7,paragraph_title,Funding,"[364.0, 1287.0, 466.0, 1316.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Funding""]",sub_subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
10,8,text,"The work described herein was supported in part by a grant from the AO Foundation (#S-14-03H) and from the Friedrichsheim Foundation (Stiftung Friedrichsheim) in Frankfurt/Main, Germany. The funders h","[362.0, 1319.0, 1149.0, 1439.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
10,9,footer,"Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821","[64.0, 1501.0, 496.0, 1524.0]",noise,0.9,"[""footer label""]",noise,0.9,,reference_like,reference_pattern,False,False
10,10,number,10/15,"[1108.0, 1502.0, 1158.0, 1523.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
11,0,header,PeerJ,"[62.0, 72.0, 155.0, 107.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,unknown_like,short_fragment,False,False
11,1,paragraph_title,Grant Disclosures,"[364.0, 164.0, 578.0, 191.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Grant Disclosures""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True
11,1,paragraph_title,Grant Disclosures,"[364.0, 164.0, 578.0, 191.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Grant Disclosures""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
11,2,text,"The following grant information was disclosed by the authors:
AO Foundation: #S-14-03H.
Friedrichsheim Foundation.","[363.0, 197.0, 917.0, 280.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,3,paragraph_title,Competing Interests,"[364.0, 303.0, 604.0, 330.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Competing Interests""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True
11,4,text,The authors declare there are no competing interests.,"[363.0, 336.0, 838.0, 361.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,5,paragraph_title,Author Contributions,"[365.0, 380.0, 614.0, 406.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Author Contributions""]",backmatter_heading_candidate,0.8,body_zone,support_like,none,True,True
11,6,text,"● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.","[364.0, 413.0, 1158.0, 497.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,7,text,"- Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figures and/or tables.","[364.0, 502.0, 1157.0, 556.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,8,text,"● John Howard Barker contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.","[365.0, 563.0, 1138.0, 618.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,9,paragraph_title,Data Availability,"[365.0, 637.0, 556.0, 665.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Data Availability""]",backmatter_heading_candidate,0.8,body_zone,heading_like,short_fragment,True,True
11,10,text,The following information was supplied regarding data availability:,"[364.0, 670.0, 961.0, 696.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,11,text,The raw data has been supplied as Supplementary Files.,"[388.0, 701.0, 884.0, 726.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,12,paragraph_title,Supplemental Information,"[364.0, 745.0, 667.0, 774.0]",backmatter_heading,0.8,"[""backmatter heading on page 11: Supplemental Information""]",backmatter_heading_candidate,0.8,body_zone,heading_like,none,True,True
11,13,text,Supplemental information for this article can be found online at http://dx.doi.org/10.7717/peerj.2821#supplemental-information.,"[363.0, 778.0, 1158.0, 835.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,body_zone,body_like,none,True,True
Friedrichsheim Foundation.","[363.0, 197.0, 917.0, 280.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,3,paragraph_title,Competing Interests,"[364.0, 303.0, 604.0, 330.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Competing Interests""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
11,4,text,The authors declare there are no competing interests.,"[363.0, 336.0, 838.0, 361.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,5,paragraph_title,Author Contributions,"[365.0, 380.0, 614.0, 406.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author Contributions""]",subsection_heading,0.6,body_zone,support_like,none,True,True
11,6,text,"● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.","[364.0, 413.0, 1158.0, 497.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,7,text,"- Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figures and/or tables.","[364.0, 502.0, 1157.0, 556.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,8,text,"● John Howard Barker contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.","[365.0, 563.0, 1138.0, 618.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,9,paragraph_title,Data Availability,"[365.0, 637.0, 556.0, 665.0]",subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Data Availability""]",subsection_heading,0.6,body_zone,heading_like,short_fragment,True,True
11,10,text,The following information was supplied regarding data availability:,"[364.0, 670.0, 961.0, 696.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,11,text,The raw data has been supplied as Supplementary Files.,"[388.0, 701.0, 884.0, 726.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,12,paragraph_title,Supplemental Information,"[364.0, 745.0, 667.0, 774.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Supplemental Information""]",backmatter_boundary_candidate,0.5,body_zone,heading_like,none,True,True
11,13,text,Supplemental information for this article can be found online at http://dx.doi.org/10.7717/peerj.2821#supplemental-information.,"[363.0, 778.0, 1158.0, 835.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
11,14,paragraph_title,REFERENCES,"[365.0, 874.0, 562.0, 904.0]",reference_heading,0.9,"[""references heading: REFERENCES""]",reference_heading,0.9,reference_zone,heading_like,short_fragment,True,True
11,15,reference_content,"Amini AR, Laurencin CT, Nukavarapu SP. 2012. Bone tissue engineering: recent advances and challenges. Critical Reviews in Biomedical Engineering 40:363–408. DOI 10.1615/CritRevBiomedEng.v40.i5.10.","[369.0, 925.0, 1106.0, 1008.0]",reference_item,0.85,"[""reference content label: Amini AR, Laurencin CT, Nukavarapu SP. 2012. Bone tissue eng""]",reference_item,0.85,reference_zone,reference_like,citation_line,True,True
11,16,reference_content,"Balint R, Cassidy NJ, Cartmell SH. 2013. Electrical stimulation: a novel tool for tissue engineering. Tissue Engineering Part B: Reviews 19:48–57.

1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 header_image [67.0, 127.0, 262.0, 313.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False True
3 1 1 doc_title In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells [362.0, 124.0, 1123.0, 264.0] paper_title 0.6 0.8 ["page-1 frontmatter title guard: In vitro effect of direct current electrical stimulation on "] ["page-1 zone title_zone: In vitro effect of direct current electrical stimulation on "] paper_title 0.6 0.8 frontmatter_main_zone support_like none True True
4 1 2 text Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishnu Thottakkattumana Parameswaran $ ^{1} $ and John Howard Barker $ ^{1} $ [361.0, 293.0, 1159.0, 350.0] authors 0.8 ["page-1 zone author_zone: Sahba Mobini $ ^{1,2,*} $, Liudmila Leppik $ ^{1,*} $, Vishn"] authors 0.8 frontmatter_main_zone support_like none True True
5 1 3 text $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Experimental Orthopedics and Trauma Surgery, Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany [355.0, 361.0, 1119.0, 404.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{1} $ Frankfurt Initiative for Regenerative Medicine, Exp"] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
6 1 4 text $ ^{2} $School of Materials, Faculty of Engineering and Physical Sciences, University of Manchester, Manchester, United Kingdom [355.0, 406.0, 1126.0, 447.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{2} $School of Materials, Faculty of Engineering and Phys"] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
7 1 5 text These authors contributed equally to this work. [357.0, 449.0, 712.0, 472.0] frontmatter_noise frontmatter_support 0.8 0.78 ["page-1 zone journal_furniture_zone: These authors contributed equally to this work."] ["first-surviving-page support text: These authors contributed equally to this work."] frontmatter_noise frontmatter_support 0.8 0.78 frontmatter_main_zone support_like none False True False True
8 1 6 paragraph_title ABSTRACT [388.0, 510.0, 548.0, 539.0] abstract_heading 0.95 ["abstract heading"] abstract_heading 0.95 frontmatter_main_zone heading_like short_fragment True True
9 1 7 text Submitted 12 July 2016 Accepted 22 November 2016 Published 12 January 2017 [65.0, 948.0, 295.0, 1014.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Submitted 12 July 2016\nAccepted 22 November 2016\nPublished 1"] frontmatter_noise 0.8 frontmatter_main_zone support_like none False False
10 1 8 abstract Background. Electrical stimulation (ES) has been successfully used to treat bone defects clinically. Recently, both cellular and molecular approaches have demonstrated that ES can change cell behavior [383.0, 555.0, 1148.0, 1036.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
18 1 16 text Subjects Bioengineering, Cell Biology, Orthopedics [362.0, 1087.0, 788.0, 1112.0] frontmatter_noise 0.7 ["keyword-like block: Subjects Bioengineering, Cell Biology, Orthopedics"] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
19 1 17 text Keywords Direct current electrical stimulation, Bone marrow-derived mesenchymal stem cells, Adipose tissue-derived mesenchymal stem cells, Bone tissue engineering [361.0, 1114.0, 1136.0, 1166.0] frontmatter_noise 0.7 ["keyword-like block: Keywords Direct current electrical stimulation, Bone marrow-"] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
20 1 18 paragraph_title INTRODUCTION [363.0, 1201.0, 585.0, 1231.0] section_heading 0.9 ["explicit scholarly heading: INTRODUCTION"] section_heading 0.9 body_zone heading_like canonical_section_name True True
21 1 19 text Large segment bone defects, caused by open fractures, non-unions, infections and tumor resection are a major challenge in trauma and orthopedic surgery. Complications associated with current treatment [361.0, 1245.0, 1159.0, 1423.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
22 1 20 footer How to cite this article Mobini et al. (2017), In vitro effect of direct current electrical stimulation on rat mesenchymal stem cells. PeerJ 5:e2821; DOI 10.7717/peerj.2821 [362.0, 1497.0, 1143.0, 1534.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
23 2 0 header PeerJ [61.0, 71.0, 156.0, 107.0] noise 0.9 ["header label"] noise 0.9 frontmatter_side_zone support_like short_fragment False False
24 2 1 text hold great potential for achieving optimal bone healing while eliminating the associated drawbacks of conventional treatments (Petite et al., 2000). [361.0, 167.0, 1149.0, 223.0] frontmatter_support unknown_structural 0.6 0.8 ["default body_paragraph for text label"] ["page-1 zone author_zone: hold great potential for achieving optimal bone healing whil"] body_paragraph authors 0.6 0.8 body_zone body_like none True False True
28 2 5 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [63.0, 1501.0, 496.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 frontmatter_main_zone reference_like reference_pattern False False
29 2 6 number 2/15 [1117.0, 1503.0, 1158.0, 1522.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
30 3 0 header PeerJ [61.0, 71.0, 156.0, 107.0] noise 0.9 ["header label"] noise 0.9 body_zone unknown_like short_fragment False False
31 3 1 text both the proliferative and the differentiation potential of stem cells. Specifically, ES has been shown to influence cell proliferation and differentiation in tissue engineering applications (Balint, [361.0, 167.0, 1163.0, 670.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
32 3 2 text In the present study we exposed rat BM-MSCs and AT-MSCs to DC ES and compared osteogenic differentiation behavior in both cell types. [363.0, 673.0, 1156.0, 730.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
33 3 3 paragraph_title MATERIALS AND METHODS Groups [363.0, 756.0, 748.0, 824.0] section_heading 0.6 ["unnumbered paragraph_title, inferred level section_heading: MATERIALS AND METHODS Groups"] section_heading 0.6 body_zone heading_like none True True
34 3 4 footer [364.0, 796.0, 459.0, 824.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like empty False False
35 3 5 text We designed our experiments to compare electrically stimulated (ES) versus not stimulated (Control) cell groups. Each group included both BM- and AT-derived rat MSCs, cultivated in osteogenic differen [362.0, 827.0, 1161.0, 977.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
36 3 6 paragraph_title Cell preparation and culture [364.0, 991.0, 692.0, 1020.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Cell preparation and culture"] subsection_heading 0.6 body_zone heading_like none True True
37 3 7 text Sprague-Dawley (SD) rat MSC from bone marrow (RASMX-01001) and adipose tissue (RASMD-01001) were both obtained from Cyagen (CA, USA). Frozen vials of cells were thawed, cultured, and expanded to reach [362.0, 1024.0, 1160.0, 1439.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
38 3 8 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [63.0, 1501.0, 496.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 reference_like reference_pattern False False
45 4 5 paragraph_title Cell viability and activity [363.0, 1048.0, 652.0, 1076.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity"] subsection_heading 0.6 body_zone heading_like none True True
46 4 6 text To confirm that the oxidation–reduction and electrochemical reactions of the metallic electrodes in the DC ES chamber were not cytotoxic, cell viability and metabolic activity were assessed by 3-(4,5- [360.0, 1081.0, 1161.0, 1379.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
47 4 7 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [64.0, 1501.0, 496.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 reference_like reference_pattern False False
48 4 8 number 4/15 [1117.0, 1502.0, 1158.0, 1522.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
49 5 0 header PeerJ [61.0, 71.0, 156.0, 107.0] noise 0.9 ["header label"] noise 0.9 body_zone unknown_like short_fragment False False
50 5 1 paragraph_title Osteogenic differentiation [362.0, 165.0, 669.0, 192.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Osteogenic differentiation"] subsection_heading 0.6 body_zone heading_like none True True
51 5 2 text Alizarin Red stains calcium deposits in the cells, indicating the presence of functional osteocytes. Cultured cells were washed twice with PBS and fixed with 4% paraformaldehyde (Sigma Aldrich, Münche [361.0, 197.0, 1161.0, 403.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
52 5 3 text Transcription quantitative Polymerase Chain Reaction (RT-qPCR) technique. In brief, total RNA was isolated using an Aurum RNA isolation kit (BioRad, München, Germany) according to the manufacturer's i [360.0, 417.0, 1159.0, 1151.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
62 6 5 footer [363.0, 1175.0, 760.0, 1204.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like empty False False
63 6 6 text In order to optimize the electrical stimulation regime, first we exposed cells in culture to 10, 50, 100, and 200 mV/mm of DC ES for 1 h and found that 200 mV/mm caused cell lysis due to electro-chemi [362.0, 1208.0, 1158.0, 1387.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
64 6 7 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [64.0, 1501.0, 495.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 reference_like reference_pattern False False
65 6 8 number 6/15 [1117.0, 1502.0, 1158.0, 1523.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
66 7 0 header PeerJ [61.0, 70.0, 156.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone unknown_like short_fragment False False
67 7 1 chart [372.0, 171.0, 1043.0, 729.0] media_asset figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone body_like empty True True
68 7 2 figure_title Figure 3 Cell viability. Measured by MTT assay, compared between electrically stimulated and non-stimulated controls. No significant difference in cell viability was detected between ES and non-stimul [373.0, 749.0, 1147.0, 840.0] figure_caption_candidate figure_caption 0.92 ["figure_title label: Figure 3 Cell viability. Measured by MTT assay, compared bet"] figure_caption 0.92 display_zone legend_like figure_number False True False True
69 7 3 paragraph_title Cell viability and activity [363.0, 870.0, 651.0, 899.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Cell viability and activity"] subsection_heading 0.6 body_zone heading_like none True True
71 7 5 paragraph_title Osteogenic differentiation [363.0, 1187.0, 669.0, 1215.0] subsection_heading 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Osteogenic differentiation"] subsection_heading 0.6 body_zone heading_like none True True
72 7 6 text The influence of electrical stimulation on osteogenic differentiation of rat AT- and BM-MSCs in culture were investigated after seven and 14 days and compared to controls. Figures 2A and 2B shows Aliz [361.0, 1219.0, 1146.0, 1427.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
73 7 7 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [63.0, 1501.0, 496.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 reference_like reference_pattern False False
74 7 8 number 7/15 [1117.0, 1502.0, 1158.0, 1523.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
75 8 0 header PeerJ [61.0, 71.0, 156.0, 107.0] noise 0.9 ["header label"] noise 0.9 body_zone unknown_like short_fragment False False
76 8 1 text (10 and 50 mV/mm) electrical fields, was not significant. However, initial morphological changes in both cell types were present at day 7, in cells exposed to electrical field of 50 mV/mm (Figs. 2C an [362.0, 167.0, 1153.0, 252.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
77 8 2 text Osteogenic phenotype gene expression was investigated by means of RT-qPCR analysis, in both ES and control groups of AT-MSCs and BM-MSCs at three, seven, and 14 days, (Fig. 4). In both BM- and AT-MSCs [361.0, 256.0, 1161.0, 608.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
78 8 3 paragraph_title DISCUSSION [364.0, 629.0, 546.0, 659.0] section_heading 0.9 ["explicit scholarly heading: DISCUSSION"] section_heading 0.9 body_zone heading_like canonical_section_name True True
91 9 7 chart [765.0, 768.0, 1075.0, 1013.0] media_asset figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
92 9 8 figure_title Days post culture in osteogenic differentiation supplemented medium [374.0, 1046.0, 1143.0, 1077.0] figure_caption_candidate 0.85 ["figure_title label: Days post culture in osteogenic differentiation supplemented"] figure_caption 0.85 body_zone legend_like none False False
93 9 9 text Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2, (B) Osteopontin, (C) Collagen Type1 (Col1A2) in BM-MSCs; (D) Runx2, (E) Osteopontin and (F) Col1A2 in AT-MSCs, in both [373.0, 1101.0, 1143.0, 1258.0] figure_caption_candidate figure_caption 0.9 ["figure prefix matched: Figure 4 RT-qPCR results. Temporal changes in messenger RNA ", "long text, reduced confidence", "near figure media assets"] figure_caption 0.9 display_zone legend_like figure_number False True False True
94 9 10 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [64.0, 1501.0, 495.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 reference_like reference_pattern False False
95 9 11 number 9/15 [1117.0, 1502.0, 1158.0, 1522.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
96 10 0 header PeerJ [61.0, 71.0, 156.0, 108.0] noise 0.9 ["header label"] noise 0.9 body_zone unknown_like short_fragment False False
97 10 1 text the known differences in osteogenic differentiation capacity between BM- and AT-derived MSC. Namely, studies that suggest AT-MSCs have less osteogenic potential than BM-MSCs (Ratanavaraporn et al., 20 [361.0, 167.0, 1162.0, 313.0] body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
98 10 2 text Our results indicate that in control groups (osteogenic supplemented medium, without electrical stimulation), both in BM- and AT-MSCs, only a slight difference exists in temporal expression patterns o [362.0, 317.0, 1161.0, 462.0] body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
99 10 3 text Runx2 is known as a master osteogenic transcription factor. Runx2 activates and regulates osteogenesis as the targeted gene of many signaling pathways, including transforming growth factor-beta 1 (TGF [361.0, 465.0, 1161.0, 914.0] body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
100 10 4 paragraph_title CONCLUSIONS [364.0, 939.0, 578.0, 970.0] section_heading 0.9 ["explicit scholarly heading: CONCLUSIONS"] section_heading 0.9 body_zone heading_like canonical_section_name True True
101 10 5 text We have demonstrated that DC ES promotes Runx2, Osteopontin and Col1A2 expression in BM-MSCs already at 7 days. Our results indicate that DC ES effects osteogenic gene expression, in both BM- and AT-M [361.0, 983.0, 1158.0, 1192.0] body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
102 10 6 paragraph_title ADDITIONAL INFORMATION AND DECLARATIONS [371.0, 1224.0, 1050.0, 1256.0] backmatter_boundary_candidate body_paragraph 0.5 ["backmatter boundary candidate: ADDITIONAL INFORMATION AND DECLARATIONS"] backmatter_boundary_candidate 0.5 body_zone body_like none True True
103 10 7 paragraph_title Funding [364.0, 1287.0, 466.0, 1316.0] backmatter_heading sub_subsection_heading 0.8 0.6 ["backmatter heading on page 10: Funding"] ["unnumbered paragraph_title, inferred level sub_subsection_heading: Funding"] backmatter_heading_candidate sub_subsection_heading 0.8 0.6 body_zone heading_like short_fragment True True
104 10 8 text The work described herein was supported in part by a grant from the AO Foundation (#S-14-03H) and from the Friedrichsheim Foundation (Stiftung Friedrichsheim) in Frankfurt/Main, Germany. The funders h [362.0, 1319.0, 1149.0, 1439.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
105 10 9 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [64.0, 1501.0, 496.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 reference_like reference_pattern False False
106 10 10 number 10/15 [1108.0, 1502.0, 1158.0, 1523.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
107 11 0 header PeerJ [62.0, 72.0, 155.0, 107.0] noise 0.9 ["header label"] noise 0.9 body_zone unknown_like short_fragment False False
108 11 1 paragraph_title Grant Disclosures [364.0, 164.0, 578.0, 191.0] backmatter_heading subsection_heading 0.8 0.6 ["backmatter heading on page 11: Grant Disclosures"] ["unnumbered paragraph_title, inferred level subsection_heading: Grant Disclosures"] backmatter_heading_candidate subsection_heading 0.8 0.6 body_zone heading_like short_fragment True True
109 11 2 text The following grant information was disclosed by the authors: AO Foundation: #S-14-03H. Friedrichsheim Foundation. [363.0, 197.0, 917.0, 280.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
110 11 3 paragraph_title Competing Interests [364.0, 303.0, 604.0, 330.0] backmatter_heading subsection_heading 0.8 0.6 ["backmatter heading on page 11: Competing Interests"] ["unnumbered paragraph_title, inferred level subsection_heading: Competing Interests"] backmatter_heading_candidate subsection_heading 0.8 0.6 body_zone heading_like short_fragment True True
111 11 4 text The authors declare there are no competing interests. [363.0, 336.0, 838.0, 361.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
112 11 5 paragraph_title Author Contributions [365.0, 380.0, 614.0, 406.0] backmatter_heading subsection_heading 0.8 0.6 ["backmatter heading on page 11: Author Contributions"] ["unnumbered paragraph_title, inferred level subsection_heading: Author Contributions"] backmatter_heading_candidate subsection_heading 0.8 0.6 body_zone support_like none True True
113 11 6 text ● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper. [364.0, 413.0, 1158.0, 497.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
114 11 7 text - Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figures and/or tables. [364.0, 502.0, 1157.0, 556.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
115 11 8 text ● John Howard Barker contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper. [365.0, 563.0, 1138.0, 618.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
116 11 9 paragraph_title Data Availability [365.0, 637.0, 556.0, 665.0] backmatter_heading subsection_heading 0.8 0.6 ["backmatter heading on page 11: Data Availability"] ["unnumbered paragraph_title, inferred level subsection_heading: Data Availability"] backmatter_heading_candidate subsection_heading 0.8 0.6 body_zone heading_like short_fragment True True
117 11 10 text The following information was supplied regarding data availability: [364.0, 670.0, 961.0, 696.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
118 11 11 text The raw data has been supplied as Supplementary Files. [388.0, 701.0, 884.0, 726.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
119 11 12 paragraph_title Supplemental Information [364.0, 745.0, 667.0, 774.0] backmatter_heading 0.8 0.5 ["backmatter heading on page 11: Supplemental Information"] ["backmatter boundary candidate: Supplemental Information"] backmatter_heading_candidate backmatter_boundary_candidate 0.8 0.5 body_zone heading_like none True True
120 11 13 text Supplemental information for this article can be found online at http://dx.doi.org/10.7717/peerj.2821#supplemental-information. [363.0, 778.0, 1158.0, 835.0] backmatter_body body_paragraph 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
121 11 14 paragraph_title REFERENCES [365.0, 874.0, 562.0, 904.0] reference_heading 0.9 ["references heading: REFERENCES"] reference_heading 0.9 reference_zone heading_like short_fragment True True
122 11 15 reference_content Amini AR, Laurencin CT, Nukavarapu SP. 2012. Bone tissue engineering: recent advances and challenges. Critical Reviews in Biomedical Engineering 40:363–408. DOI 10.1615/CritRevBiomedEng.v40.i5.10. [369.0, 925.0, 1106.0, 1008.0] reference_item 0.85 ["reference content label: Amini AR, Laurencin CT, Nukavarapu SP. 2012. Bone tissue eng"] reference_item 0.85 reference_zone reference_like citation_line True True
123 11 16 reference_content Balint R, Cassidy NJ, Cartmell SH. 2013. Electrical stimulation: a novel tool for tissue engineering. Tissue Engineering Part B: Reviews 19:48–57. DOI 10.1089/ten.TEB.2012.0183. [371.0, 1016.0, 1126.0, 1096.0] reference_item 0.85 ["reference content label: Balint R, Cassidy NJ, Cartmell SH. 2013. Electrical stimulat"] reference_item 0.85 reference_zone reference_like citation_line True True
124 11 17 reference_content Balint R, Cassidy NJ, Hidalgo-Bastida LA, Cartmell S. 2013. Electrical stimulation enhanced mesenchymal stem cell gene expression for orthopaedic tissue repair. Journal of Biomaterials and Tissue Engi [370.0, 1105.0, 1155.0, 1189.0] reference_item 0.85 ["reference content label: Balint R, Cassidy NJ, Hidalgo-Bastida LA, Cartmell S. 2013. "] reference_item 0.85 reference_zone reference_like citation_line True True
125 11 18 reference_content Bodamyali T, Bhatt B, Hughes FJ, Winrow VR, Kanczler JM, Simon B, Abbott J, Blake DR, Stevens CR. 1998. Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of [371.0, 1195.0, 1130.0, 1337.0] reference_item 0.85 ["reference content label: Bodamyali T, Bhatt B, Hughes FJ, Winrow VR, Kanczler JM, Sim"] reference_item 0.85 reference_zone reference_like citation_line True True
126 11 19 reference_content Bunnell BA, Flaat M, Gagliardi C, Patel B, Ripoll C. 2008. Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45:115–120 DOI 10.1016/j.ymeth.2008.03.006. [370.0, 1344.0, 1130.0, 1427.0] reference_item 0.85 ["reference content label: Bunnell BA, Flaat M, Gagliardi C, Patel B, Ripoll C. 2008. A"] reference_item 0.85 reference_zone reference_like citation_line True True
127 11 20 footer Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821 [64.0, 1501.0, 494.0, 1524.0] noise 0.9 ["footer label"] noise 0.9 reference_zone reference_like reference_pattern False False
128 11 21 number 11/15 [1109.0, 1503.0, 1158.0, 1522.0] noise 0.9 ["page number label"] noise 0.9 tail_nonref_hold_zone unknown_like short_fragment False False
129 12 0 header PeerJ [61.0, 71.0, 156.0, 107.0] noise 0.9 ["header label"] noise 0.9 unknown_like short_fragment False False
130 12 1 reference_content Colnot C. 2011. Cell sources for bone tissue engineering: insights from basic science. Tissue Engineering Part B: Reviews 17:449–457 DOI 10.1089/ten.teb.2011.0243. [368.0, 167.0, 1113.0, 222.0] reference_item 0.85 ["reference content label: Colnot C. 2011. Cell sources for bone tissue engineering: in"] reference_item 0.85 reference_zone reference_like citation_line True True
131 12 2 reference_content Cowan CM, Shi YY, Aalami OO, Chou YF, Mari C, Thomas R, Quarto N, Contag CH, Wu B, Longaker MT. 2004. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nature Biotechnolo [369.0, 227.0, 1136.0, 311.0] reference_item 0.85 ["reference content label: Cowan CM, Shi YY, Aalami OO, Chou YF, Mari C, Thomas R, Quar"] reference_item 0.85 reference_zone reference_like citation_line True True
132 12 3 reference_content Curtis KM, Gomez LA, Rios C, Garbayo E, Raval AP, Perez-Pinzon MA, Schiller PC. 2010. EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal [370.0, 317.0, 1128.0, 430.0] reference_item 0.85 ["reference content label: Curtis KM, Gomez LA, Rios C, Garbayo E, Raval AP, Perez-Pinz"] reference_item 0.85 reference_zone reference_like citation_line True True
133 12 4 reference_content De Girolamo L, Sartori MF, Albisetti W, Brini AT. 2007. Osteogenic differentiation of human adipose-derived stem cells: comparison of two different inductive media. Journal of Tissue Engineering and R [370.0, 436.0, 1094.0, 549.0] reference_item 0.85 ["reference content label: De Girolamo L, Sartori MF, Albisetti W, Brini AT. 2007. Oste"] reference_item 0.85 reference_zone unknown_like none True True

14
audit/2GN9LMCW/changed_blocks_after_fallback.json
View file

@ -241,7 +241,7 @@
{
"block_id": "p7:1",
"truth_role": "figure_asset",
"pipe_role": "media_asset",
"pipe_role": "figure_asset",
"pipe_zone": "body_zone",
"pipe_text_len": 0,
"role_match": true,
@ -259,7 +259,7 @@
{
"block_id": "p9:2",
"truth_role": "figure_asset",
"pipe_role": "media_asset",
"pipe_role": "figure_asset",
"pipe_zone": "body_zone",
"pipe_text_len": 0,
"role_match": true,
@ -268,7 +268,7 @@
{
"block_id": "p9:3",
"truth_role": "figure_asset",
"pipe_role": "media_asset",
"pipe_role": "figure_asset",
"pipe_zone": "body_zone",
"pipe_text_len": 0,
"role_match": true,
@ -277,7 +277,7 @@
{
"block_id": "p9:4",
"truth_role": "figure_asset",
"pipe_role": "media_asset",
"pipe_role": "figure_asset",
"pipe_zone": "body_zone",
"pipe_text_len": 0,
"role_match": true,
@ -286,7 +286,7 @@
{
"block_id": "p9:5",
"truth_role": "figure_asset",
"pipe_role": "media_asset",
"pipe_role": "figure_asset",
"pipe_zone": "body_zone",
"pipe_text_len": 0,
"role_match": true,
@ -295,7 +295,7 @@
{
"block_id": "p9:6",
"truth_role": "figure_asset",
"pipe_role": "media_asset",
"pipe_role": "figure_asset",
"pipe_zone": "body_zone",
"pipe_text_len": 0,
"role_match": true,
@ -304,7 +304,7 @@
{
"block_id": "p9:7",
"truth_role": "figure_asset",
"pipe_role": "media_asset",
"pipe_role": "figure_asset",
"pipe_zone": "body_zone",
"pipe_text_len": 0,
"role_match": true,

21
audit/2GN9LMCW/coverage_check.json
View file

@ -2,30 +2,15 @@
"paper_key": "2GN9LMCW",
"mode": "high-risk",
"required_block_ids": [
"p10:6",
"p10:7",
"p10:8",
"p11:1",
"p11:10",
"p11:11",
"p11:12",
"p11:13",
"p11:14",
"p11:15",
"p11:16",
"p11:17",
"p11:18",
"p11:19",
"p11:2",
"p11:20",
"p11:21",
"p11:3",
"p11:4",
"p11:5",
"p11:6",
"p11:7",
"p11:8",
"p11:9",
"p1:0",
"p1:1",
"p1:10",
@ -48,20 +33,16 @@
"p1:8",
"p1:9",
"p4:1",
"p4:2",
"p4:6",
"p6:1",
"p6:2",
"p7:1",
"p7:2",
"p9:2",
"p9:3",
"p9:4",
"p9:5",
"p9:6",
"p9:7",
"p9:8",
"p9:9"
"p9:8"
],
"reviewed_block_ids": [
"p10:6",

102
audit/2GN9LMCW/fulltext_block_mapping_summary.json
View file

@ -1,7 +1,7 @@
{
"mappable_block_count": 156,
"mappable_block_count": 154,
"found_count": 117,
"missing_count": 39,
"missing_count": 37,
"rows": [
{
"block_id": "p1:1",
@ -43,6 +43,26 @@
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p1:5",
"page": 1,
"role": "frontmatter_support",
"zone": "frontmatter_main_zone",
"render_default": true,
"snippet": "These authors contributed equally to this work.",
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p1:13",
"page": 1,
"role": "frontmatter_support",
"zone": "frontmatter_main_zone",
"render_default": true,
"snippet": "Corresponding author Sahba Mobini, sahba.mobini@manchester.ac.uk, sahba.mobini@g",
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p1:18",
"page": 1,
@ -86,9 +106,9 @@
{
"block_id": "p2:1",
"page": 2,
"role": "frontmatter_support",
"role": "unknown_structural",
"zone": "body_zone",
"render_default": true,
"render_default": false,
"snippet": "hold great potential for achieving optimal bone healing while eliminating the as",
"found_in_fulltext": false,
"fulltext_offset": -1
@ -127,7 +147,7 @@
"block_id": "p2:5",
"page": 2,
"role": "noise",
"zone": "",
"zone": "frontmatter_main_zone",
"render_default": false,
"snippet": "Mobini et al. (2017), PeerJ, DOI 10.7717/peerj.2821",
"found_in_fulltext": false,
@ -243,16 +263,6 @@
"found_in_fulltext": true,
"fulltext_offset": 233
},
{
"block_id": "p4:2",
"page": 4,
"role": "figure_caption_candidate",
"zone": "display_zone",
"render_default": false,
"snippet": "Figure 1 Setup for delivering direct current electrical stimulation to the cells",
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p4:3",
"page": 4,
@ -403,16 +413,6 @@
"found_in_fulltext": true,
"fulltext_offset": 233
},
{
"block_id": "p6:2",
"page": 6,
"role": "figure_caption_candidate",
"zone": "display_zone",
"render_default": false,
"snippet": "Figure 2 Calcium deposition. Calcium deposition stained using Alizarin Red S for",
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p6:3",
"page": 6,
@ -473,16 +473,6 @@
"found_in_fulltext": true,
"fulltext_offset": 233
},
{
"block_id": "p7:2",
"page": 7,
"role": "figure_caption_candidate",
"zone": "display_zone",
"render_default": false,
"snippet": "Figure 3 Cell viability. Measured by MTT assay, compared between electrically st",
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p7:3",
"page": 7,
@ -663,16 +653,6 @@
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p9:9",
"page": 9,
"role": "figure_caption_candidate",
"zone": "display_zone",
"render_default": false,
"snippet": "Figure 4 RT-qPCR results. Temporal changes in messenger RNA (mRNA) of (A) Runx2,",
"found_in_fulltext": false,
"fulltext_offset": -1
},
{
"block_id": "p9:10",
"page": 9,
@ -756,7 +736,7 @@
{
"block_id": "p10:6",
"page": 10,
"role": "backmatter_boundary_candidate",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "ADDITIONAL INFORMATION AND DECLARATIONS",
@ -766,7 +746,7 @@
{
"block_id": "p10:7",
"page": 10,
"role": "backmatter_heading",
"role": "sub_subsection_heading",
"zone": "body_zone",
"render_default": true,
"snippet": "Funding",
@ -776,7 +756,7 @@
{
"block_id": "p10:8",
"page": 10,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "The work described herein was supported in part by a grant from the AO Foundatio",
@ -816,17 +796,17 @@
{
"block_id": "p11:1",
"page": 11,
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"render_default": true,
"snippet": "Grant Disclosures",
"found_in_fulltext": true,
"fulltext_offset": 22985
"fulltext_offset": 22987
},
{
"block_id": "p11:2",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "The following grant information was disclosed by the authors: AO Foundation: #S-",
@ -836,7 +816,7 @@
{
"block_id": "p11:3",
"page": 11,
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"render_default": true,
"snippet": "Competing Interests",
@ -846,7 +826,7 @@
{
"block_id": "p11:4",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "The authors declare there are no competing interests.",
@ -856,7 +836,7 @@
{
"block_id": "p11:5",
"page": 11,
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"render_default": true,
"snippet": "Author Contributions",
@ -866,7 +846,7 @@
{
"block_id": "p11:6",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "● Sahba Mobini and Liudmila Leppik conceived and designed the experiments, perfo",
@ -876,7 +856,7 @@
{
"block_id": "p11:7",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "- Vishnu Thottakkattumana Parameswaran performed the experiments, prepared figur",
@ -886,7 +866,7 @@
{
"block_id": "p11:8",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "● John Howard Barker contributed reagents/materials/analysis tools, wrote the pa",
@ -896,7 +876,7 @@
{
"block_id": "p11:9",
"page": 11,
"role": "backmatter_heading",
"role": "subsection_heading",
"zone": "body_zone",
"render_default": true,
"snippet": "Data Availability",
@ -906,7 +886,7 @@
{
"block_id": "p11:10",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "The following information was supplied regarding data availability:",
@ -916,7 +896,7 @@
{
"block_id": "p11:11",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "The raw data has been supplied as Supplementary Files.",
@ -936,7 +916,7 @@
{
"block_id": "p11:13",
"page": 11,
"role": "backmatter_body",
"role": "body_paragraph",
"zone": "body_zone",
"render_default": true,
"snippet": "Supplemental information for this article can be found online at http://dx.doi.o",

34
audit/2GN9LMCW/page_risk_summary.json
View file

@ -34,8 +34,8 @@
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 0,
"hold": 1,
"unknown_structural": 1,
"matched_figures": 0,
"ambiguous_figures": 0
}
@ -186,18 +186,13 @@
},
{
"page": 10,
"risk_score": 4,
"risk_reasons": [
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"same_page_boundary"
],
"risk_score": 0,
"risk_reasons": [],
"recommended_audit_targets": [],
"counts": {
"body_paragraph": 4,
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 3,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
@ -209,17 +204,21 @@
},
{
"page": 11,
"risk_score": 5,
"risk_score": 13,
"risk_reasons": [
"reference_heading_present"
"reference_heading_present",
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reference_span"
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 0,
"body_paragraph": 8,
"reference_item": 5,
"tail_like": 14,
"tail_like": 2,
"media_assets": 0,
"table_like": 0,
"captions": 0,
@ -308,7 +307,6 @@
6,
7,
9,
10,
11
]
}

7
audit/2GN9LMCW/reference_intrusion_candidates.json
View file

@ -419,13 +419,6 @@
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:4",
"page": 15,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

27
audit/2GN9LMCW/reference_span_audit.json
View file

@ -11,8 +11,8 @@
"end": {
"page": 15,
"column": 1,
"y": 1502.0,
"block_id": "p15:4"
"y": 377.0,
"block_id": "p15:3"
},
"heading_block_id": "p11:14",
"ordered_block_ids": [
@ -22,7 +22,6 @@
"p11:17",
"p11:18",
"p11:19",
"p11:20",
"p12:1",
"p12:2",
"p12:3",
@ -37,7 +36,6 @@
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p13:1",
"p13:2",
"p13:3",
@ -50,7 +48,6 @@
"p13:10",
"p13:11",
"p13:12",
"p13:13",
"p14:1",
"p14:2",
"p14:3",
@ -64,11 +61,9 @@
"p14:11",
"p14:12",
"p14:13",
"p14:14",
"p15:1",
"p15:2",
"p15:3",
"p15:4"
"p15:3"
],
"inside_block_ids": [
"p11:14",
@ -77,7 +72,6 @@
"p11:17",
"p11:18",
"p11:19",
"p11:20",
"p12:1",
"p12:2",
"p12:3",
@ -92,7 +86,6 @@
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p13:1",
"p13:2",
"p13:3",
@ -105,7 +98,6 @@
"p13:10",
"p13:11",
"p13:12",
"p13:13",
"p14:1",
"p14:2",
"p14:3",
@ -119,15 +111,13 @@
"p14:11",
"p14:12",
"p14:13",
"p14:14",
"p15:1",
"p15:2",
"p15:3",
"p15:4"
"p15:3"
],
"explicitly_outside_nearby_block_ids": [
"p11:13",
"p15:5"
"p15:4"
],
"intrusion_candidates": [
{
@ -549,13 +539,6 @@
"role": "reference_item",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
},
{
"block_id": "p15:4",
"page": 15,
"role": "noise",
"zone": "reference_zone",
"reason": "logical_order_between_reference_members"
}
]
}

332
audit/2H8MZ27H/audit_report.json Normal file
View file

@ -0,0 +1,332 @@
{
"paper_key": "2H8MZ27H",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:6dfd52fa9863e70ed8ef92c562f085d63516b621a6d1c70d95b02f4db7a12a6c",
"meta_json_hash": "sha256:f632db0d4b1722e88a9f07cf03908be854ca8c1fe63631bbf2b3a52a42f233ef",
"blocks_raw_hash": "sha256:b64bb8a1c439ae1419c4bb6a2c347c0e692b51d1998bfee4544901e827ccc9bb",
"structured_blocks_hash": "sha256:2232792a574579bd0dfec424e5d239e4b1a01010c15d4b02fb6b2aaaa6b199d7",
"document_structure_hash": "sha256:c4357dc81853002e113bd8eba3a4a7902387b05a2137465ba65cad4b15f3100b",
"figure_inventory_hash": "sha256:34e883202173b17b72c9e3139299bcd7259d0ad429e57e394444411f4196d2fe",
"table_inventory_hash": "sha256:86ccb48fbfd41da91e87ea2c1ef938513732868efcb5e30b31c36f96d432bba2",
"reader_figures_hash": "sha256:d6892826ff7e806ad0b677c5c0dd6b5f243259d526e8dca97ee39baa0d0ab745",
"resolved_metadata_hash": "sha256:2c24a747cf483d8399b25beaa796a49a13ed3082fc5b1da0e17630c0fed1d5f0",
"fulltext_hash": "sha256:3b891c14a39929f078490adfd93df724dc7154e88a911b043fb9a95837278148",
"block_trace_hash": "sha256:a0decc69c33c2fa8a34c7c1efbdab61260ec54501a218eca3faa08d75992632b",
"annotated_pages": {
"page_001.png": "sha256:e412e3cc8e47df28e66aeb1fee6c8a09a6ec02a2a319f2e46ad5221cf1c3e6e0",
"page_002.png": "sha256:352fac4e65b04f44defa7641a9afff474a6bfc0eb0b6ed918ca6f701b7d3de73",
"page_003.png": "sha256:810421fe246a75e0125707b5fb73266406d73f12c38740db802cad7676647a78",
"page_004.png": "sha256:c6e09ba0e846974fd5cdb66c36a97e104361aa3b6d0df656a317b3f26c215a74",
"page_005.png": "sha256:30cf14809bf835d159b36bcb8b55993eb39ff3a6da1279bcfcd4b15d54e041d8",
"page_006.png": "sha256:88bcbdb12a0ed5e679e495dd2bccb441aea4696ce6aa365749c0128c6d990360",
"page_007.png": "sha256:449ced2fc1d19d7752fae4c695cd9db2e8ea88500a1d20dc37f57a6dfd87245f",
"page_008.png": "sha256:6f1047f87c03726f4e3e5044ab7006020b09f6fd0fb4464401e0835f5f8771d5"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png",
"page_008.png"
]
},
"reviewed_pages": [
1,
2,
3,
4,
5,
6,
7,
8
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p1:17",
"p2:0",
"p2:1",
"p2:2",
"p2:3",
"p2:4",
"p2:5",
"p2:6",
"p2:7",
"p2:8",
"p2:9",
"p2:10",
"p2:11",
"p2:12",
"p2:13",
"p2:14",
"p2:15",
"p2:16",
"p2:17",
"p2:18",
"p3:0",
"p3:1",
"p3:2",
"p3:3",
"p3:4",
"p3:5",
"p3:6",
"p3:7",
"p3:8",
"p3:9",
"p3:10",
"p3:11",
"p3:12",
"p3:13",
"p3:14",
"p3:15",
"p3:16",
"p3:17",
"p3:18",
"p3:19",
"p4:0",
"p4:1",
"p4:2",
"p4:3",
"p4:4",
"p4:5",
"p4:6",
"p4:7",
"p4:8",
"p4:9",
"p4:10",
"p4:11",
"p4:12",
"p4:13",
"p4:14",
"p5:0",
"p5:1",
"p5:2",
"p5:3",
"p5:4",
"p5:5",
"p5:6",
"p5:7",
"p5:8",
"p5:9",
"p5:10",
"p5:11",
"p5:12",
"p5:13",
"p5:14",
"p5:15",
"p5:16",
"p5:17",
"p6:0",
"p6:1",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p6:12",
"p6:13",
"p6:14",
"p6:15",
"p6:16",
"p6:17",
"p6:18",
"p6:19",
"p6:20",
"p6:21",
"p6:22",
"p6:23",
"p6:24",
"p7:0",
"p7:1",
"p7:2",
"p7:3",
"p7:4",
"p7:5",
"p7:6",
"p7:7",
"p7:8",
"p7:9",
"p7:10",
"p7:11",
"p7:12",
"p7:13",
"p7:14",
"p7:15",
"p7:16",
"p7:17",
"p7:18",
"p7:19",
"p7:20",
"p7:21",
"p7:22",
"p7:23",
"p7:24",
"p7:25",
"p7:26",
"p7:27",
"p7:28",
"p7:29",
"p7:30",
"p7:31",
"p7:32",
"p7:33",
"p7:34",
"p7:35",
"p7:36",
"p7:37",
"p7:38",
"p7:39",
"p7:40",
"p7:41",
"p7:42",
"p7:43",
"p7:44",
"p7:45",
"p7:46",
"p7:47",
"p7:48",
"p7:49",
"p7:50",
"p7:51",
"p7:52",
"p7:53",
"p7:54",
"p7:55",
"p7:56",
"p7:57",
"p7:58",
"p7:59",
"p8:0",
"p8:1",
"p8:2",
"p8:3",
"p8:4",
"p8:5",
"p8:6",
"p8:7",
"p8:8",
"p8:9",
"p8:10",
"p8:11",
"p8:12",
"p8:13",
"p8:14"
],
"findings": [
{
"category": "frontmatter_error",
"severity": "major",
"block_ids": [],
"truth": "page 1 should have clearer frontmatter role resolution",
"pipeline_behavior": "frontmatter page retains elevated unknown_structural density",
"root_cause_hypothesis": "frontmatter anchor or noise routing weakness",
"evidence": {
"annotated_page": "annotated_pages/page_001.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_007.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_008.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "object_ownership_error",
"severity": "major",
"block_ids": [],
"truth": "figure/table ownership should map captions and assets coherently",
"pipeline_behavior": "ambiguous or unresolved object ownership remains in the current artifact set",
"root_cause_hypothesis": "caption-to-asset grouping ambiguity",
"evidence": {
"annotated_page": null,
"artifact": "figure_table_ownership_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:2",
"p1:7",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:16",
"p2:17",
"p3:17",
"p3:18",
"p4:12",
"p4:13",
"p5:16",
"p6:23",
"p7:2",
"p7:50",
"p7:58",
"p8:5",
"p8:13"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

20
audit/2H8MZ27H/audit_report.md Normal file
View file

@ -0,0 +1,20 @@
# OCR Truth Audit Report - 2H8MZ27H
- Mode: `high-risk`
- Status: `READY`
- Reviewed pages: [1, 2, 3, 4, 5, 6, 7, 8]
- Reviewed blocks: 190
## Findings
- `major` `frontmatter_error`: frontmatter page retains elevated unknown_structural density
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `same_page_boundary_error`: page contains mixed body/reference/tail signals
- `major` `object_ownership_error`: ambiguous or unresolved object ownership remains in the current artifact set
- `minor` `render_mapping_error`: some render-default blocks are not easily mapped into the current fulltext output
## Disposition Guidance
- Use `repair` when the finding reflects a pipeline defect worth fixing now.
- Use `residual` when the finding is real but intentionally deferred.
- Do not rewrite expected truth to make current output look correct.

1966
audit/2H8MZ27H/audit_scope.json Normal file
View file

File diff suppressed because it is too large Load diff

3826
audit/2H8MZ27H/block_coverage_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

205
audit/2H8MZ27H/block_trace.csv Normal file
View file

@ -0,0 +1,205 @@
page,block_id,raw_label,content_preview,bbox,role,role_confidence,evidence,seed_role,seed_confidence,zone,style_family,marker_type,render_default,index_default
1,0,header_image,,"[38.0, 36.0, 368.0, 196.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True
1,1,header_image,,"[603.0, 1.0, 1188.0, 199.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,frontmatter_main_zone,support_like,empty,False,True
1,2,text,OPEN,"[157.0, 300.0, 243.0, 331.0]",authors,0.6,"[""page-1 initial-lastname author byline: OPEN""]",authors,0.6,frontmatter_main_zone,support_like,short_fragment,True,True
1,3,text,"SUBJECT AREAS:
BIONANOELECTRONICS
BIOLOGICAL MODELS","[68.0, 381.0, 244.0, 466.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,frontmatter_main_zone,support_like,none,True,True
1,4,doc_title,Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/ $ \beta $-catenin Signaling Pathway,"[282.0, 283.0, 1048.0, 521.0]",paper_title,0.8,"[""page-1 zone title_zone: Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotyp""]",paper_title,0.8,frontmatter_main_zone,support_like,none,True,True
1,5,text,Received 12 December 2013,"[91.0, 503.0, 244.0, 550.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Received 12 December 2013""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,none,False,False
1,6,text,Accepted,"[164.0, 560.0, 244.0, 583.0]",frontmatter_noise,0.8,"[""page-1 zone journal_furniture_zone: Accepted""]",frontmatter_noise,0.8,frontmatter_main_zone,support_like,short_fragment,False,False
1,7,text,8 July 2014,"[147.0, 582.0, 243.0, 607.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,reference_like,reference_numeric_dot,False,False
1,8,text,Published,"[150.0, 614.0, 244.0, 638.0]",frontmatter_noise,0.7,"[""frontmatter noise text: Published""]",frontmatter_noise,0.7,frontmatter_main_zone,support_like,short_fragment,False,False
1,9,text,25 July 2014,"[137.0, 637.0, 244.0, 663.0]",non_body_insert,0.3,"[""short text, uncertain role""]",unknown_structural,0.3,body_zone,reference_like,reference_numeric_dot,False,False
1,10,text,"Correspondence and requests for materials should be addressed to Z.G.G. (gez@pku.edu.cn) or J.Z. (zhangjue@pku.edu.cn)
Kun Zhang $ ^{1} $, Jinsong Guo $ ^{2} $, Zigang Ge $ ^{1,3,4} $ & Jue Zhang $ ^{","[81.0, 712.0, 246.0, 858.0]",frontmatter_support,0.78,"[""first-surviving-page support text: Correspondence and requests for materials should be addresse""]",frontmatter_support,0.78,frontmatter_main_zone,support_like,none,True,True
1,11,text,"Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5","[282.0, 535.0, 743.0, 564.0]",authors,0.8,"[""page-1 zone author_zone: Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5""]",authors,0.8,frontmatter_main_zone,support_like,none,True,True
1,12,text," $ ^{1} $Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China, $ ^{2} $Institute of Biomechaics and Biomedical Engineering, College of Engineering, P","[281.0, 598.0, 1110.0, 703.0]",affiliation,0.8,"[""page-1 zone affiliation_zone: $ ^{1} $Department of Biomedical Engineering, College of Eng""]",affiliation,0.8,frontmatter_main_zone,support_like,affiliation_marker,True,True
1,13,abstract,"Nanosecond pulsed electric fields (nsPEFs) characterized by high voltage, low energy and non-thermal effects, have been broadly investigated as a potential tumor therapy; however, little is known abou","[280.0, 737.0, 1111.0, 947.0]",abstract_body,0.85,"[""abstract label from Paddle OCR""]",abstract_body,0.85,frontmatter_main_zone,support_like,none,True,True
1,14,text,"M illisecond or microsecond pulsed electric fields (PEFs) have been shown to facilitate delivery of drugs and transfer of genes into cells $ ^{1,2} $. PEFs induce a transient transmembrane potential o","[281.0, 977.0, 1111.0, 1297.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,15,text,"Chondrocytes are critical for maintenance and regeneration of cartilage, and several signaling pathways regulate phenotypes of differentiation, hypertrophy, proliferation, and dedifferentiation. Trans","[281.0, 1297.0, 1112.0, 1492.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
1,16,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1520.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
1,17,number,1,"[1094.0, 1523.0, 1107.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
2,0,header,www.nature.com/scientificreports,"[761.0, 30.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,frontmatter_side_zone,support_like,none,False,False
2,1,header_image,,"[1125.0, 1.0, 1191.0, 74.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True
2,2,image,,"[79.0, 96.0, 581.0, 552.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
2,3,figure_title,Figure 1 | Strategic map exploring the effects of nsPEFs on chondrocytes.,"[80.0, 566.0, 587.0, 590.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 1 | Strategic map exploring the effects of nsPEFs on ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True
2,4,text,"ments were used in the aforementioned research due to the thermal effects of PEFs. Although the biological effects induced by nsPEFs are largely unknown, it has been reported that MAPK pathways, gener","[79.0, 614.0, 588.0, 743.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,5,text,"In this study, we evaluated the phenotypic effects of nsPEFs on chondrocytes and found that nsPEFs enhanced cell proliferation while causing dedifferentiation by upregulating gene expression of type I","[80.0, 743.0, 589.0, 832.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,6,text,"II. We then explored whether activation of the wnt/b-catenin signal-
ing pathway was involved in these phenotypic changes (Fig. 1).","[602.0, 99.0, 1108.0, 146.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,7,paragraph_title,Results,"[602.0, 163.0, 681.0, 185.0]",section_heading,0.9,"[""explicit scholarly heading: Results""]",section_heading,0.9,frontmatter_side_zone,heading_like,canonical_section_name,True,True
2,8,text,"nsPEFs enhance proliferation of chondrocytes. Based on favorable results obtained in previous reports and our pilot study, 5 pulses of 100 ns nsPEFs at 10 or 20 kV/cm were used in this current study $","[600.0, 187.0, 1111.0, 525.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,9,text,"nsPEFs downregulate glycosaminoglycan (GAG) production. Results obtained demonstrated that nsPEFs at 10 kV/cm decreased GAG production at day 1 (0.91-fold), day 3 (0.96-fold) and day 7 (0.97-fold). Mo","[600.0, 538.0, 1111.0, 773.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,10,text,nsPEFs downregulate expression of functional genes. Effects of nsPEFs on gene expression were evaluated at 1 hour and 24 hours,"[601.0, 784.0, 1112.0, 830.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
2,11,chart,,"[232.0, 867.0, 581.0, 1110.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
2,12,figure_title,b,"[611.0, 857.0, 636.0, 889.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
2,13,chart,,"[610.0, 869.0, 954.0, 1108.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
2,14,chart,,"[237.0, 1134.0, 581.0, 1378.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
2,15,chart,,"[605.0, 1131.0, 954.0, 1377.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
2,16,figure_title,"Figure 2 | Induction of dedifferentiated phenotype of chondrocytes after nsPEF treatment. (a) The toxicity of nsPEFs at 10 kV/cm and 20 kV/cm was evaluated at days 1, 3 and 7. nsPEFs had a nontoxic ef","[80.0, 1388.0, 1110.0, 1497.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 2 | Induction of dedifferentiated phenotype of chondr""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True
2,17,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1520.0, 518.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
2,18,number,2,"[1092.0, 1522.0, 1110.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
3,0,header,www.nature.com/scientificreports,"[761.0, 30.0, 1109.0, 54.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
3,1,header_image,,"[1125.0, 1.0, 1191.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True
3,2,figure_title,a,"[218.0, 112.0, 242.0, 137.0]",figure_inner_text,0.9,"[""panel label / figure inner text: a""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
3,3,chart,,"[219.0, 114.0, 581.0, 369.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,4,figure_title,b,"[606.0, 105.0, 630.0, 137.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
3,5,chart,,"[606.0, 110.0, 976.0, 368.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,6,figure_title,C,"[218.0, 387.0, 241.0, 414.0]",figure_inner_text,0.9,"[""panel label / figure inner text: C""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
3,7,chart,,"[220.0, 389.0, 582.0, 641.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,8,chart,,"[607.0, 383.0, 976.0, 642.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,9,figure_title,e,"[216.0, 656.0, 242.0, 682.0]",figure_inner_text,0.9,"[""panel label / figure inner text: e""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
3,10,chart,,"[211.0, 666.0, 580.0, 911.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
3,11,figure_title,Figure 3 | Functional gene expression of chondrocytes after nsPEF treatment. Gene expression was analyzed at 1 hour for immediate effects and following a recovery period of 24 hours after 10 kV/cm and,"[78.0, 924.0, 1107.0, 1011.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 3 | Functional gene expression of chondrocytes after ""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True
3,12,text,"after nsPEF treatment. At 1 hour, nsPEFs at 10 kV/cm decreased gene expression of COL II significantly to 0.43-fold (p = 0.017), while nsPEFs at 20 kV/cm decreased COL II gene expression to 0.45-fold ","[79.0, 1033.0, 588.0, 1286.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,13,text,"At 24 hours after nsPEF treatment, gene expression showed an increase compared to the gene expression at 1 hour. An additive effect of COL I was indicated by an increase in the gene expression to 1.75","[79.0, 1287.0, 588.0, 1434.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,14,text,"nsPEFs activate wnt/β-catenin signaling pathway. Expression of β-catenin protein increased significantly by 45% (p = 0.005) and 42% (p = 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment, resp","[80.0, 1453.0, 588.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,15,text,"(p 5 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment,
respectively (Fig. 4a, b). As shown, b-catenin accumulated in the
nucleus of the cells after nsPEF treatment (Fig. 4c). 10 kV/cm and
20 ","[601.0, 1033.0, 1111.0, 1288.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,16,text,"Our findings demonstrated that after 24 hours, nsPEFs induced a decrease in Lef1 and c-jun gene expression in comparison to the gene expression observed after 1 hour. nsPEFs increased gene expression ","[601.0, 1287.0, 1111.0, 1433.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,17,text,Inhibition of wnt/ $ \beta $-catenin pathway partially blocks effects of nsPEFs. Incubation with XAV939 reverted nsPEF-induced upregulation of $ \beta $-,"[601.0, 1453.0, 1109.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
3,18,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1521.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
3,19,number,3,"[1093.0, 1523.0, 1109.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
4,0,header,www.nature.com/scientificreports,"[761.0, 31.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
4,1,header_image,,"[1126.0, 1.0, 1191.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True
4,2,chart,,"[109.0, 114.0, 324.0, 272.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,3,chart,,"[364.0, 103.0, 577.0, 322.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,4,image,,"[102.0, 333.0, 550.0, 760.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
4,5,figure_title,Figure 4 | Activated wnt/β-catenin signaling pathway after nsPEF treatment. (a) β-catenin protein expression performed with western blotting analysis using specific antibodies for β-catenin at 1 hour ,"[80.0, 776.0, 588.0, 966.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 4 | Activated wnt/\u03b2-catenin signaling pathway after n""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True
4,6,text,"catenin (Fig. 6j–6l), wnt7a gene (Fig. 6d) and the downstream genes of wnt, Lef1 (Fig. 6a), c-jun (Fig. 6b) and cyclin D1 (Fig. 6c) by inhibition ranging from 30% to 60%. When the effects of inhibitio","[79.0, 989.0, 588.0, 1307.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,7,paragraph_title,Discussion,"[81.0, 1326.0, 190.0, 1347.0]",section_heading,0.9,"[""explicit scholarly heading: Discussion""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
4,8,text,nsPEFs have profound effects on multiple organelles of a cell. nsPEFs generate large transmembrane potentials across cellular organelles with limited thermal effects. The most significant characterist,"[79.0, 1348.0, 589.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,9,text,"pulse duration decreases, the outer membrane is likely shorted, and
the applied voltage appears mainly across the interior organelles of
the cell27. nsPEFs modify the potential and phosphatidylserine ","[602.0, 100.0, 1112.0, 312.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,10,text,"Effects of nsPEFs are usually transient. Typically, the nanopores can be formed within 5 nanoseconds after nsPEF treatment $ ^{7} $. Calcium ions efflux from the endoplasmic reticulum within 10 second","[601.0, 314.0, 1111.0, 630.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,11,text,Fine-tuned activation of the wnt/β-catenin signaling pathway is essential to regulate the fate of chondrocytes in cartilage. The wnt/β-catenin pathway is involved in dedifferentiation of cultured chon,"[602.0, 629.0, 1111.0, 1074.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,12,text,The fact that inhibition of the wnt/ $ \beta $-catenin signaling can only partially block the effects of nsPEFs on chondrocytes hints that there are other mechanisms involved. The functional crosstalk,"[601.0, 1073.0, 1112.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
4,13,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1520.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
4,14,number,4,"[1093.0, 1523.0, 1109.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
5,0,header,www.nature.com/scientificreports,"[761.0, 30.0, 1110.0, 54.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
5,1,header_image,,"[1125.0, 1.0, 1191.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True
5,2,chart,,"[251.0, 111.0, 587.0, 354.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,3,figure_title,b,"[597.0, 104.0, 620.0, 136.0]",figure_inner_text,0.9,"[""panel label / figure inner text: b""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
5,4,chart,,"[597.0, 111.0, 934.0, 353.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,5,chart,,"[255.0, 370.0, 589.0, 613.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,6,figure_title,d,"[597.0, 365.0, 622.0, 395.0]",figure_inner_text,0.9,"[""panel label / figure inner text: d""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
5,7,chart,,"[593.0, 372.0, 935.0, 611.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
5,8,figure_title,"Figure 5 | Influence of nsPEFs on gene expression related to wnt/ $ \beta $-catenin signaling. Gene expression was detected immediately at 1 hour and following a 24 hour recovery after 0, 10 and 20 kV","[80.0, 623.0, 1109.0, 688.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 5 | Influence of nsPEFs on gene expression related to""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True
5,9,text,"due to its folded spiral structure, it is sensitive to nsPEFs and forms speckles after nsPEF treatment $ ^{28} $. nsPEFs induce small nuclear ribonucleoprotein particles and RNA-protein complexes, whi","[79.0, 710.0, 588.0, 987.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,10,text,"nsPEFs may have different effects on suspended and attached cells in vitro. Cells in a suspended state were subjected to nsPEFs within electric cuvettes, which provided an instantaneous and consistent","[79.0, 987.0, 589.0, 1499.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,11,text,"development of a real-time visual microfluidic system for monitoring
adherent cells combined with nsPEFs52.","[601.0, 710.0, 1110.0, 753.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,12,text,"As nsPEFs do not exist in a natural cellular environment, a comprehensive understanding of nsPEFs as well as the effects of superficial stimuli need to be further explored to determine any difference ","[600.0, 756.0, 1112.0, 1011.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,13,paragraph_title,Methods,"[603.0, 1042.0, 696.0, 1064.0]",section_heading,0.9,"[""explicit scholarly heading: Methods""]",section_heading,0.9,body_zone,heading_like,canonical_section_name,True,True
5,14,text,"Cell culture. Porcine articular cartilage tissue was cut into small pieces by a lancet, and washed with phosphate-buffered saline (PBS). The tissue pieces were collected and digested in 0.1% Collagena","[601.0, 1069.0, 1110.0, 1313.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,15,text,"Application of nsPEFs. The nsPEF generator was applied as previously described $ ^{54} $. Digital phosphor oscilloscope (DPO4054, Tektronix) with a probe (P6015A, Tektronix) was utilized to monitor th","[601.0, 1339.0, 1112.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
5,16,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1521.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
5,17,number,5,"[1093.0, 1523.0, 1108.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
6,0,header,www.nature.com/scientificreports,"[762.0, 30.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,body_zone,body_like,none,False,False
6,1,header_image,,"[1125.0, 1.0, 1190.0, 75.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,body_zone,unknown_like,empty,False,True
6,2,chart,,"[102.0, 104.0, 287.0, 319.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,3,chart,,"[302.0, 112.0, 493.0, 320.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,4,chart,,"[500.0, 111.0, 701.0, 319.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,5,chart,,"[703.0, 113.0, 899.0, 319.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,6,chart,,"[902.0, 119.0, 1101.0, 320.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,7,chart,,"[89.0, 344.0, 289.0, 545.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,8,chart,,"[294.0, 342.0, 494.0, 545.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,9,chart,,"[502.0, 344.0, 704.0, 544.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,10,chart,,"[717.0, 341.0, 918.0, 544.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,11,figure_title,j,"[105.0, 571.0, 120.0, 602.0]",figure_inner_text,0.9,"[""panel label / figure inner text: j""]",figure_inner_text,0.9,display_zone,legend_like,panel_label,True,True
6,12,image,,"[101.0, 569.0, 352.0, 778.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,13,chart,,"[376.0, 573.0, 578.0, 788.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,14,chart,,"[611.0, 561.0, 860.0, 796.0]",figure_asset,0.85,"[""media label: chart""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,15,image,,"[612.0, 559.0, 1065.0, 796.0]",figure_asset,0.85,"[""media label: image""]",media_asset,0.85,body_zone,unknown_like,empty,True,True
6,16,figure_title,"Figure 6 | Influence of inhibition of wnt/ $ \beta $-catenin signaling on gene and protein expression after nsPEF treatment. Gene expression was detected at 1 hour after 0, 10 and 20 kV/cm nsPEF treat","[77.0, 812.0, 1112.0, 960.0]",figure_caption,0.95,"[""Frontiers figure title pattern: Figure 6 | Influence of inhibition of wnt/ $ \\beta $-catenin""]",figure_caption,0.95,display_zone,legend_like,figure_number,True,True
6,17,text,"Celltoxicity. The toxicity of nsPEFs was evaluated by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT, M2128, Sigma) at days 1, 3 and 7.5.0 × 10³ chondrocytes/well were seeded in","[80.0, 982.0, 589.0, 1121.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,18,text,"Cell proliferation. Cell proliferation was assayed with Hoechst 33258 (H6024, Sigma) at days 1, 3 and 7. Chondrocytes in each well were lysed with 100 μL sterile distilled DNAse-free H₂O, and the diss","[80.0, 1135.0, 587.0, 1258.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,19,text,"GAG content. Chondrocytes were digested in 0.5 mg/mL proteinase K at 56°C for 12 hours, and were subsequently examined with dimethylmethylene blue (DMMB, 341088, Sigma). The digestive solution was sha","[79.0, 1272.0, 587.0, 1396.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,20,text,"Gene expression. Total RNA was extracted and isolated from chondrocytes with Trizol Reagent (206101, New Industry) following the standard protocol, and quantified with Nanodrop spectrophotometer (ND-1","[80.0, 1409.0, 588.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,21,text,"cycler (Mycycler, Bio-Rad). Quantitative real-time PCR was performed in the PCR
system (Pikoreal 96, Thermo) with RealMasterMix SYBR Green (FP202, Tiangen)
following the manufacturer’s procedures. The","[601.0, 982.0, 1111.0, 1374.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,22,text,"Western blotting. Chondrocytes were lysed by RIPA lysis buffer (R0020, Solarbio) with fresh protease inhibitor of 0.1% phenylmethanesulfonyl fluoride (PMSF, Solarbio). Total cell lysate was boiled aft","[602.0, 1391.0, 1108.0, 1498.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
6,23,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1521.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,body_zone,body_like,none,False,False
6,24,number,6,"[1093.0, 1523.0, 1109.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,body_zone,body_like,short_fragment,False,False
7,0,header,www.nature.com/scientificreports,"[761.0, 31.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
7,1,header_image,,"[1125.0, 1.0, 1190.0, 74.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True
7,2,text,"and $ \beta $-actin (4970, Cell Signaling) was combined with HRP-linked antibody of anti-rabbit IgG (7074, Cell Signaling). The complex of the antigen and the antibody was illuminated by chemilumines","[89.0, 98.0, 591.0, 171.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,3,text,"Immunofluorescence. Immunofluorescence was utilized to confirm the location of $ \beta $-catenin protein. After nsPEF treatment, chondrocytes were fixed with 4% paraformaldehyde for 15 minutes and wa","[81.0, 189.0, 586.0, 329.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,4,text,Statistical analysis. Analysis was performed using SPSS V13.0 (SPSS Inc.) one-way ANOVA with the least significant difference (LSD) test (data presented as mean ± s.d). The statistical significance wa,"[81.0, 348.0, 585.0, 419.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,body_zone,body_like,none,True,True
7,5,reference_content,"1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Membrane electroporation theories: a review. Med. Biol. Eng. Comput. 44, 5–14 (2006).","[82.0, 452.0, 586.0, 486.0]",reference_item,0.85,"[""reference content label: 1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Mem""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,6,reference_content,"2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Nanosecond Pulsed Electric Fields into He La Cells Expressing Enhanced Green Fluorescent Protein and Fluorescence Lifetime Microscopy. J. Phys","[83.0, 487.0, 586.0, 553.0]",reference_item,0.85,"[""reference content label: 2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Na""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,7,reference_content,"3. Weaver, J. C. Electroporation of biological membranes from multicellular to nano scales. IEEE Trans. Dielectr. Electr. Insul. 10, 754–768 (2003).","[83.0, 556.0, 587.0, 590.0]",reference_item,0.85,"[""reference content label: 3. Weaver, J. C. Electroporation of biological membranes fro""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,8,reference_content,"4. Schoenbach, K. H. et al. Ultrashort electrical pulses open a new gateway into biological cells. Proc. IEEE 92, 1122–1137 (2004).","[84.0, 592.0, 571.0, 626.0]",reference_item,0.85,"[""reference content label: 4. Schoenbach, K. H. et al. Ultrashort electrical pulses ope""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,9,reference_content,"5. Silve, A., Leray, I. & Mir, L. M. Demonstration of cell membrane permeabilization to medium-sized molecules caused by a single 10 ns electric pulse. Bioelectrochemistry 87, 260–264 (2012).","[83.0, 627.0, 586.0, 675.0]",reference_item,0.85,"[""reference content label: 5. Silve, A., Leray, I. & Mir, L. M. Demonstration of cell m""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,10,reference_content,"6. Rems, L. et al. Cell electrofusion using nanosecond electric pulses. Sci. Rep. 3, 3382; doi:10.1038/srep03382 (2013).","[84.0, 678.0, 587.0, 712.0]",reference_item,0.85,"[""reference content label: 6. Rems, L. et al. Cell electrofusion using nanosecond elect""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,11,reference_content,"7. Hu, Q., Joshi, R. P. & Schoenbach, K. H. Simulations of nanopore formation and phosphatidylserine externalization in lipid membranes subjected to a high-intensity, ultrashort electric pulse. Phys. ","[83.0, 713.0, 586.0, 765.0]",reference_item,0.85,"[""reference content label: 7. Hu, Q., Joshi, R. P. & Schoenbach, K. H. Simulations of n""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,12,reference_content,"8. Schoenbach, K. H., Beebe, S. J. & Buescher, E. S. Intracellular effect of ultrashort electrical pulses. Bioelectromagnetics 22, 440–448 (2001).","[83.0, 765.0, 586.0, 799.0]",reference_item,0.85,"[""reference content label: 8. Schoenbach, K. H., Beebe, S. J. & Buescher, E. S. Intrace""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,13,reference_content,"9. White, J. A., Blackmore, P. F., Schoenbach, K. H. & Beebe, S. J. Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields. J. Biol. Chem. 279, 22964–22972 (2004","[84.0, 801.0, 577.0, 851.0]",reference_item,0.85,"[""reference content label: 9. White, J. A., Blackmore, P. F., Schoenbach, K. H. & Beebe""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,14,reference_content,"10. Morotomi-Yano, K., Akiyama, H. & Yano, K. Nanosecond pulsed electric fields activate MAPK pathways in human cells. Arch. Biochem. Biophys. 515, 99–106 (2011).","[85.0, 852.0, 583.0, 903.0]",reference_item,0.85,"[""reference content label: 10. Morotomi-Yano, K., Akiyama, H. & Yano, K. Nanosecond pul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,15,reference_content,"11. Garon, E. B. et al. In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies. Int. J. Cancer 121, 675–682 (2007).","[84.0, 905.0, 585.0, 956.0]",reference_item,0.85,"[""reference content label: 11. Garon, E. B. et al. In vitro and in vivo evaluation and ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,16,reference_content,"12. Ren, W., Sain, N. M. & Beebe, S. J. Nanosecond pulsed electric fields (nsPEFs) activate intrinsic caspase-dependent and caspase-independent cell death in Jurkat cells. Biochem. Biophys. Res. Commu","[85.0, 957.0, 586.0, 1008.0]",reference_item,0.85,"[""reference content label: 12. Ren, W., Sain, N. M. & Beebe, S. J. Nanosecond pulsed el""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,17,reference_content,"13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. & Stacey, M. W. Enhanced Killing Effect of Nanosecond Pulse Electric Fields on PANC1 and Jurkat Cell Lines in the Presence of Tween 80. The ","[85.0, 1010.0, 587.0, 1076.0]",reference_item,0.85,"[""reference content label: 13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,18,reference_content,"14. van der Kraan, P. M., Davidson, E. N. B., Blom, A. & van den Berg, W. B. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis Modulation and integration of signaling pathw","[84.0, 1079.0, 585.0, 1146.0]",reference_item,0.85,"[""reference content label: 14. van der Kraan, P. M., Davidson, E. N. B., Blom, A. & van""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,19,reference_content,"15. Grimsrud, C. D. et al. BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog. Journal of Orthopaedic Research 19, 18–25 (2001).","[85.0, 1148.0, 587.0, 1183.0]",reference_item,0.85,"[""reference content label: 15. Grimsrud, C. D. et al. BMP signaling stimulates chondroc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,20,reference_content,"16. Riemer, S., Gebhard, S., Beier, F., Poschl, E. & von der Mark, K. Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: Localization of a PTH/PTHrP-responsive region","[85.0, 1184.0, 588.0, 1250.0]",reference_item,0.85,"[""reference content label: 16. Riemer, S., Gebhard, S., Beier, F., Poschl, E. & von der""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,21,reference_content,"17. Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocyte phenotype by beta-catenin. Mol Biol Cell 13, 118a–118a (2002).","[85.0, 1252.0, 575.0, 1287.0]",reference_item,0.85,"[""reference content label: 17. Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocy""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,22,reference_content,"18. Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. Chem. 280, 21653–21660 (2","[85.0, 1289.0, 586.0, 1338.0]",reference_item,0.85,"[""reference content label: 18. Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metallop""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,23,reference_content,"19. Fini, M. et al. Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation? Tissue Eng Part B-Re 19, 353–367 (2013).","[85.0, 1340.0, 588.0, 1389.0]",reference_item,0.85,"[""reference content label: 19. Fini, M. et al. Functional Tissue Engineering in Articul""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,24,reference_content,"20. Macginitie, L. A., Gluzband, Y. A. & Grodzinsky, A. J. Electric-Field Stimulation Can Increase Protein-Synthesis in Articular-Cartilage Explants. Journal of Orthopaedic Research 12, 151–160 (1994)","[84.0, 1392.0, 585.0, 1443.0]",reference_item,0.85,"[""reference content label: 20. Macginitie, L. A., Gluzband, Y. A. & Grodzinsky, A. J. E""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,25,reference_content,"21. Lippiello, L., Chakkalakal, D. & Connolly, J. F. Pulsing Direct Current-Induced Repair of Articular-Cartilage in Rabbit Osteochondral Defects. Journal of Orthopaedic Research 8, 266–275 (1990).","[84.0, 1444.0, 581.0, 1495.0]",reference_item,0.85,"[""reference content label: 21. Lippiello, L., Chakkalakal, D. & Connolly, J. F. Pulsing""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,26,reference_content,"22. Wang, W., Wang, Z. Y., Zhang, G. H., Clark, C. C. & Brighton, C. T. Up-regulation of chondrocyte matrix genes and products by electric fields. Clin Orthop Relat R, S163–S173 (2004).","[604.0, 101.0, 1108.0, 150.0]",reference_item,0.85,"[""reference content label: 22. Wang, W., Wang, Z. Y., Zhang, G. H., Clark, C. C. & Brig""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,27,reference_content,"23. Morotomi-Yano, K., Oyadomari, S., Akiyama, H. & Yano, K. Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2 alpha phosphory","[604.0, 151.0, 1108.0, 219.0]",reference_item,0.85,"[""reference content label: 23. Morotomi-Yano, K., Oyadomari, S., Akiyama, H. & Yano, K.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,28,reference_content,"24. Ge, Z. G., Baguenard, S., Lim, L. Y., Wee, A. & Khor, E. Hydroxyapatite-chitin materials as potential tissue engineered bone substitutes. Biomaterials 25, 1049–1058 (2004).","[606.0, 219.0, 1100.0, 269.0]",reference_item,0.85,"[""reference content label: 24. Ge, Z. G., Baguenard, S., Lim, L. Y., Wee, A. & Khor, E.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,29,reference_content,"25. Schoenbach, K. H., Katsuki, S., Stark, R. H., Buescher, E. S. & Beebe, S. J. Bioelectrics - New applications for pulsed power technology. IEEE Trans. Plasma Sci. 30, 293–300 (2002).","[606.0, 271.0, 1109.0, 320.0]",reference_item,0.85,"[""reference content label: 25. Schoenbach, K. H., Katsuki, S., Stark, R. H., Buescher, ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,30,reference_content,"26. Frey, W. et al. Plasma membrane voltage changes during nanosecond pulsed electric field exposure. Biophysical Journal 90, 3608–3615 (2006).","[604.0, 324.0, 1098.0, 354.0]",reference_item,0.85,"[""reference content label: 26. Frey, W. et al. Plasma membrane voltage changes during n""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,31,reference_content,"27. Ellappan, P. & Sundararajan, R. A simulation study of the electrical model of a biological cell. J. Electrost. 63, 297–307 (2005).","[605.0, 356.0, 1105.0, 389.0]",reference_item,0.85,"[""reference content label: 27. Ellappan, P. & Sundararajan, R. A simulation study of th""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,32,reference_content,"28. Stacey, M. et al. Differential effects in cells exposed to ultra-short, high intensity electric fields: cell survival, DNA damage, and cell cycle analysis. Mutat Res-Gen Tox En 542, 65–75 (2003).","[606.0, 391.0, 1108.0, 439.0]",reference_item,0.85,"[""reference content label: 28. Stacey, M. et al. Differential effects in cells exposed ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,33,reference_content,"29. Chen, N. Y. et al. Nanosecond electric pulses penetrate the nucleus an enhance speckle formation. Biochem. Biophys. Res. Commun. 364, 220–225 (2007).","[607.0, 441.0, 1104.0, 474.0]",reference_item,0.85,"[""reference content label: 29. Chen, N. Y. et al. Nanosecond electric pulses penetrate ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,34,reference_content,"30. Pakhomova, O. N. et al. Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media. Arch. Biochem. Biophys. 527, 55–64 (2012).","[606.0, 476.0, 1106.0, 509.0]",reference_item,0.85,"[""reference content label: 30. Pakhomova, O. N. et al. Oxidative effects of nanosecond ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,35,reference_content,"31. Zhang, J. et al. Nanosecond pulse electric field (nanopulse): A novel non-ligand agonist for platelet activation. Arch. Biochem. Biophys. 471, 240–248 (2008).","[607.0, 508.0, 1106.0, 543.0]",reference_item,0.85,"[""reference content label: 31. Zhang, J. et al. Nanosecond pulse electric field (nanopu""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,36,reference_content,"32. Beebe, S. J., Blackmore, P. F., White, J., Joshi, R. P. & Schoenbach, K. H. Nanosecond pulsed electric fields modulate cell function through intracellular signal transduction mechanisms. Physiol M","[605.0, 544.0, 1099.0, 594.0]",reference_item,0.85,"[""reference content label: 32. Beebe, S. J., Blackmore, P. F., White, J., Joshi, R. P. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,37,reference_content,"33. Hwang, S. G., Yu, S. S., Poo, H. & Chun, J. S. c-Jun/activator protein-1 mediates interleukin-1 beta-induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. J. Bio","[606.0, 594.0, 1109.0, 643.0]",reference_item,0.85,"[""reference content label: 33. Hwang, S. G., Yu, S. S., Poo, H. & Chun, J. S. c-Jun/act""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,38,reference_content,"34. Novak, A. & Dedhar, S. Signaling through beta-catenin and Lef/Tcf. Cellular and Molecular Life Sciences 56, 523–537 (1999).","[606.0, 645.0, 1110.0, 678.0]",reference_item,0.85,"[""reference content label: 34. Novak, A. & Dedhar, S. Signaling through beta-catenin an""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,39,reference_content,"35. Shtutman, M. et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. P Natl Acad Sci USA 96, 5522–5527 (1999).","[607.0, 679.0, 1085.0, 712.0]",reference_item,0.85,"[""reference content label: 35. Shtutman, M. et al. The cyclin D1 gene is a target of th""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,40,reference_content,"36. Hwang, S. G., Yu, S. S., Lee, S. W. & Chun, J. S. Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway. Feb 579, 4837–4842 (2005).","[606.0, 713.0, 1101.0, 746.0]",reference_item,0.85,"[""reference content label: 36. Hwang, S. G., Yu, S. S., Lee, S. W. & Chun, J. S. Wnt-3a""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,41,reference_content,"37. Beebe, S. J., Fox, P. M., Rec, L. J., Willis, L. K. & Schoenbach, K. H. Nanosecond, high-intensity pulsed electric fields induce apoptosis in human cells. Faseb J 17, 1493–+ (2003).","[607.0, 747.0, 1107.0, 796.0]",reference_item,0.85,"[""reference content label: 37. Beebe, S. J., Fox, P. M., Rec, L. J., Willis, L. K. & Sc""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,42,reference_content,"38. Bell, D. M. et al. SOX9 directly regulates the type-II collagen gene. Nat Genet 16, 174–178 (1997).","[606.0, 798.0, 1107.0, 831.0]",reference_item,0.85,"[""reference content label: 38. Bell, D. M. et al. SOX9 directly regulates the type-II c""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,43,reference_content,"39. de Crombrugghe, B. et al. Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol 19, 389–394 (2000).","[606.0, 832.0, 1055.0, 865.0]",reference_item,0.85,"[""reference content label: 39. de Crombrugghe, B. et al. Transcriptional mechanisms of ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,44,reference_content,"40. Ryu, J. H. et al. Regulation of the chondrocyte phenotype by beta-catenin. Development 129, 5541–5550 (2002).","[607.0, 867.0, 1073.0, 899.0]",reference_item,0.85,"[""reference content label: 40. Ryu, J. H. et al. Regulation of the chondrocyte phenotyp""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,45,reference_content,"41. Zhu, M. et al. Activation of beta-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult beta-Catenin Conditional Activation Mice. J Bone Miner Res 24, 12–21 (","[606.0, 901.0, 1097.0, 950.0]",reference_item,0.85,"[""reference content label: 41. Zhu, M. et al. Activation of beta-Catenin Signaling in A""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,46,reference_content,"42. Zhu, M. et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum. 58, 2053–2064 (2008).","[606.0, 951.0, 1109.0, 985.0]",reference_item,0.85,"[""reference content label: 42. Zhu, M. et al. Inhibition of beta-catenin signaling in a""]",reference_item,0.85,reference_zone,unknown_like,heading_numbered,True,True
7,47,reference_content,"43. Ibey, B. L. et al. Dose-Dependent Thresholds of 10-ns Electric Pulse Induced Plasma Membrane Disruption and Cytotoxicity in Multiple Cell Lines. PLoS One 6 (2011).","[606.0, 986.0, 1109.0, 1034.0]",reference_item,0.85,"[""reference content label: 43. Ibey, B. L. et al. Dose-Dependent Thresholds of 10-ns El""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,48,reference_content,"44. Morotomi-Yano, K., Uemura, Y., Katsuki, S., Akiyama, H. & Yano, K. Activation of the JNK pathway by nanosecond pulsed electric fields. Biochem. Biophys. Res. Commun. 408, 471–476 (2011).","[606.0, 1037.0, 1107.0, 1086.0]",reference_item,0.85,"[""reference content label: 44. Morotomi-Yano, K., Uemura, Y., Katsuki, S., Akiyama, H. ""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,49,reference_content,"45. Scarlett, S. S., White, J. A., Blackmore, P. F., Schoenbach, K. H. & Kolb, J. F. Regulation of intracellular calcium concentration by nanosecond pulsed electric fields. Biochim. Biophys. Acta-Biom","[606.0, 1088.0, 1106.0, 1137.0]",reference_item,0.85,"[""reference content label: 45. Scarlett, S. S., White, J. A., Blackmore, P. F., Schoenb""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,50,reference_content,"46. Nutt, L. K. et al. Bax-mediated Ca $ ^{2+} $ mobilization promotes cytochrome c release during apoptosis. J. Biol. Chem. 277, 20301–20308 (2002).","[607.0, 1139.0, 1108.0, 1173.0]",reference_item,0.85,"[""reference content label: 46. Nutt, L. K. et al. Bax-mediated Ca $ ^{2+} $ mobilizatio""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,51,reference_content,"47. Lin, J. C. Microwave Auditory Phenomenon. Proc. IEEE 68, 67–73 (1980).","[605.0, 1173.0, 1077.0, 1189.0]",reference_item,0.85,"[""reference content label: 47. Lin, J. C. Microwave Auditory Phenomenon. Proc. IEEE 68,""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,52,reference_content,"48. Pakhomov, A. G. et al. Long-lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric field (nsPEF). Bioelectromagnetics 28, 655–663 (2007).","[607.0, 1190.0, 1081.0, 1239.0]",reference_item,0.85,"[""reference content label: 48. Pakhomov, A. G. et al. Long-lasting plasma membrane perm""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,53,reference_content,"49. Kirawanich, P., Pausawasdi, N., Srisawat, C., Yakura, S. J. & Islam, N. E. An FDTD Interaction Scheme of a High-Intensity Nanosecond-Pulsed Electric-Field System for In Vitro Cell Apoptosis Applic","[606.0, 1241.0, 1108.0, 1306.0]",reference_item,0.85,"[""reference content label: 49. Kirawanich, P., Pausawasdi, N., Srisawat, C., Yakura, S.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,54,reference_content,"50. Wang, N., Butler, J. P. & Ingber, D. E. Mechanotransduction across the Cell-Surface and through the Cytoskeleton. Science 260, 1124–1127 (1993).","[606.0, 1308.0, 1090.0, 1342.0]",reference_item,0.85,"[""reference content label: 50. Wang, N., Butler, J. P. & Ingber, D. E. Mechanotransduct""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,55,reference_content,"51. Thompson, G. L., Roth, C., Tolstykh, G., Kuipers, M. & Ibey, B. L. Role of Cytoskeleton and Elastic Moduli in Cellular Response to Nanosecond Pulsed Electric Fields. Proc Spie 8585 (2013).","[606.0, 1343.0, 1092.0, 1392.0]",reference_item,0.85,"[""reference content label: 51. Thompson, G. L., Roth, C., Tolstykh, G., Kuipers, M. & I""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,56,reference_content,"52. Dalmay, C., De Menorval, M. A., Francais, O., Mir, L. M. & Le Pioufle, B. A microfluidic device with removable packaging for the real time visualisation of intracellular effects of nanosecond elec","[605.0, 1394.0, 1108.0, 1460.0]",reference_item,0.85,"[""reference content label: 52. Dalmay, C., De Menorval, M. A., Francais, O., Mir, L. M.""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,57,reference_content,"53. Beebe, S. J. Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs). Int J Nanomed 8 (2013).","[606.0, 1462.0, 1108.0, 1494.0]",reference_item,0.85,"[""reference content label: 53. Beebe, S. J. Cell responses without receptors and ligand""]",reference_item,0.85,reference_zone,reference_like,reference_numeric_dot,True,True
7,58,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[83.0, 1521.0, 517.0, 1541.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
7,59,number,7,"[1093.0, 1523.0, 1108.0, 1540.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
8,0,header,www.nature.com/scientificreports,"[762.0, 31.0, 1109.0, 53.0]",noise,0.9,"[""header label""]",noise,0.9,,unknown_like,none,False,False
8,1,header_image,,"[1126.0, 1.0, 1190.0, 74.0]",unknown_structural,0.2,"[""unrecognized label 'header_image'""]",unknown_structural,0.2,,unknown_like,empty,False,True
8,2,text,"54. Wang, J. et al. Synergistic Effects of Nanosecond Pulsed Electric Fields Combined with Low Concentration of Gemcitabine on Human Oral Squamous Cell Carcinoma In Vitro. PLoS One 7 (2012).","[82.0, 99.0, 587.0, 153.0]",reference_item,0.6,"[""reference-like pattern: 54. Wang, J. et al. Synergistic Effects of Nanosecond Pulsed""]",reference_item,0.6,reference_zone,reference_like,reference_numeric_dot,True,True
8,3,paragraph_title,Acknowledgments,"[82.0, 198.0, 270.0, 220.0]",sub_subsection_heading,0.6,"[""unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments""]",sub_subsection_heading,0.6,tail_nonref_hold_zone,heading_like,short_fragment,True,True
8,4,text,"This work was supported by National Basic Research Program of China (973 Program) (2012CB619100), and National Natural Science Foundation of China grant (81271722). The authors would like to thank A. ","[80.0, 220.0, 587.0, 291.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
8,5,paragraph_title,Author contributions,"[81.0, 313.0, 286.0, 333.0]",unknown_structural,0.6,"[""unnumbered paragraph_title, inferred level subsection_heading: Author contributions""]",subsection_heading,0.6,tail_nonref_hold_zone,support_like,none,False,True
8,6,text,"Z.G. and J.Z. designed this study, whereas K.Z. and J.G. were involved in the experimentation. K.Z. and Z.G. analyzed data and wrote the manuscript with assistance from J.G. and J.Z. All authors revie","[81.0, 334.0, 578.0, 388.0]",body_paragraph,0.6,"[""default body_paragraph for text label""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
8,7,paragraph_title,Additional information,"[604.0, 100.0, 829.0, 122.0]",backmatter_heading,0.5,"[""backmatter boundary candidate: Additional information""]",backmatter_boundary_candidate,0.5,,heading_like,none,True,True
8,8,text,Supplementary information accompanies this paper at http://www.nature.com/scientificreports,"[602.0, 122.0, 1057.0, 158.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""tail_nonref_hold_zone excluded from body flow""]",backmatter_body,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
8,9,text,Competing financial interests: The authors declare no competing financial interests.,"[602.0, 163.0, 1083.0, 181.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
8,10,text,"How to cite this article: Zhang, K., Guo, J., Ge, Z. & Zhang, J. Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/ $ \beta $-catenin Signaling Pathway. Sci. R","[602.0, 186.0, 1108.0, 241.0]",frontmatter_noise,0.8,"[""frontmatter phrase: How to cite this article: Zhang, K., Guo, J., Ge, Z. & Zhang""]",frontmatter_noise,0.8,,unknown_like,none,False,False
8,11,text,"This work is licensed under a Creative Commons Attribution 4.0 International
License. The images or other third party material in this article are included in the
article’s Creative Commons license, u","[685.0, 258.0, 1111.0, 365.0]",backmatter_body,0.6,"[""default body_paragraph for text label"", ""promoted in tail spread from body_paragraph""]",body_paragraph,0.6,tail_nonref_hold_zone,unknown_like,none,True,True
8,12,image,,"[605.0, 261.0, 683.0, 290.0]",media_asset,0.85,"[""media label: image""]",media_asset,0.85,,unknown_like,empty,True,True
8,13,footer,SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836,"[82.0, 1520.0, 517.0, 1542.0]",noise,0.9,"[""footer label""]",noise,0.9,,unknown_like,none,False,False
8,14,number,8,"[1093.0, 1522.0, 1109.0, 1541.0]",noise,0.9,"[""page number label""]",noise,0.9,,unknown_like,short_fragment,False,False
1 page block_id raw_label content_preview bbox role role_confidence evidence seed_role seed_confidence zone style_family marker_type render_default index_default
2 1 0 header_image [38.0, 36.0, 368.0, 196.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False True
3 1 1 header_image [603.0, 1.0, 1188.0, 199.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 frontmatter_main_zone support_like empty False True
4 1 2 text OPEN [157.0, 300.0, 243.0, 331.0] authors 0.6 ["page-1 initial-lastname author byline: OPEN"] authors 0.6 frontmatter_main_zone support_like short_fragment True True
5 1 3 text SUBJECT AREAS: BIONANOELECTRONICS BIOLOGICAL MODELS [68.0, 381.0, 244.0, 466.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 frontmatter_main_zone support_like none True True
6 1 4 doc_title Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/ $ \beta $-catenin Signaling Pathway [282.0, 283.0, 1048.0, 521.0] paper_title 0.8 ["page-1 zone title_zone: Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotyp"] paper_title 0.8 frontmatter_main_zone support_like none True True
7 1 5 text Received 12 December 2013 [91.0, 503.0, 244.0, 550.0] frontmatter_noise 0.7 ["frontmatter noise text: Received 12 December 2013"] frontmatter_noise 0.7 frontmatter_main_zone support_like none False False
8 1 6 text Accepted [164.0, 560.0, 244.0, 583.0] frontmatter_noise 0.8 ["page-1 zone journal_furniture_zone: Accepted"] frontmatter_noise 0.8 frontmatter_main_zone support_like short_fragment False False
9 1 7 text 8 July 2014 [147.0, 582.0, 243.0, 607.0] non_body_insert 0.3 ["short text, uncertain role"] unknown_structural 0.3 body_zone reference_like reference_numeric_dot False False
10 1 8 text Published [150.0, 614.0, 244.0, 638.0] frontmatter_noise 0.7 ["frontmatter noise text: Published"] frontmatter_noise 0.7 frontmatter_main_zone support_like short_fragment False False
11 1 9 text 25 July 2014 [137.0, 637.0, 244.0, 663.0] non_body_insert 0.3 ["short text, uncertain role"] unknown_structural 0.3 body_zone reference_like reference_numeric_dot False False
12 1 10 text Correspondence and requests for materials should be addressed to Z.G.G. (gez@pku.edu.cn) or J.Z. (zhangjue@pku.edu.cn) Kun Zhang $ ^{1} $, Jinsong Guo $ ^{2} $, Zigang Ge $ ^{1,3,4} $ & Jue Zhang $ ^{ [81.0, 712.0, 246.0, 858.0] frontmatter_support 0.78 ["first-surviving-page support text: Correspondence and requests for materials should be addresse"] frontmatter_support 0.78 frontmatter_main_zone support_like none True True
13 1 11 text Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5 [282.0, 535.0, 743.0, 564.0] authors 0.8 ["page-1 zone author_zone: Kun Zhang1, Jinsong Guo2, Zigang Ge1,3,4 & Jue Zhang2,5"] authors 0.8 frontmatter_main_zone support_like none True True
14 1 12 text $ ^{1} $Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China, $ ^{2} $Institute of Biomechaics and Biomedical Engineering, College of Engineering, P [281.0, 598.0, 1110.0, 703.0] affiliation 0.8 ["page-1 zone affiliation_zone: $ ^{1} $Department of Biomedical Engineering, College of Eng"] affiliation 0.8 frontmatter_main_zone support_like affiliation_marker True True
15 1 13 abstract Nanosecond pulsed electric fields (nsPEFs) characterized by high voltage, low energy and non-thermal effects, have been broadly investigated as a potential tumor therapy; however, little is known abou [280.0, 737.0, 1111.0, 947.0] abstract_body 0.85 ["abstract label from Paddle OCR"] abstract_body 0.85 frontmatter_main_zone support_like none True True
16 1 14 text M illisecond or microsecond pulsed electric fields (PEFs) have been shown to facilitate delivery of drugs and transfer of genes into cells $ ^{1,2} $. PEFs induce a transient transmembrane potential o [281.0, 977.0, 1111.0, 1297.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
17 1 15 text Chondrocytes are critical for maintenance and regeneration of cartilage, and several signaling pathways regulate phenotypes of differentiation, hypertrophy, proliferation, and dedifferentiation. Trans [281.0, 1297.0, 1112.0, 1492.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
18 1 16 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [82.0, 1520.0, 517.0, 1542.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
19 1 17 number 1 [1094.0, 1523.0, 1107.0, 1541.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
20 2 0 header www.nature.com/scientificreports [761.0, 30.0, 1109.0, 53.0] noise 0.9 ["header label"] noise 0.9 frontmatter_side_zone support_like none False False
21 2 1 header_image [1125.0, 1.0, 1191.0, 74.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 body_zone unknown_like empty False True
22 2 2 image [79.0, 96.0, 581.0, 552.0] media_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
23 2 3 figure_title Figure 1 | Strategic map exploring the effects of nsPEFs on chondrocytes. [80.0, 566.0, 587.0, 590.0] figure_caption 0.95 ["Frontiers figure title pattern: Figure 1 | Strategic map exploring the effects of nsPEFs on "] figure_caption 0.95 display_zone legend_like figure_number True True
24 2 4 text ments were used in the aforementioned research due to the thermal effects of PEFs. Although the biological effects induced by nsPEFs are largely unknown, it has been reported that MAPK pathways, gener [79.0, 614.0, 588.0, 743.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
25 2 5 text In this study, we evaluated the phenotypic effects of nsPEFs on chondrocytes and found that nsPEFs enhanced cell proliferation while causing dedifferentiation by upregulating gene expression of type I [80.0, 743.0, 589.0, 832.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
26 2 6 text II. We then explored whether activation of the wnt/b-catenin signal- ing pathway was involved in these phenotypic changes (Fig. 1). [602.0, 99.0, 1108.0, 146.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
27 2 7 paragraph_title Results [602.0, 163.0, 681.0, 185.0] section_heading 0.9 ["explicit scholarly heading: Results"] section_heading 0.9 frontmatter_side_zone heading_like canonical_section_name True True
28 2 8 text nsPEFs enhance proliferation of chondrocytes. Based on favorable results obtained in previous reports and our pilot study, 5 pulses of 100 ns nsPEFs at 10 or 20 kV/cm were used in this current study $ [600.0, 187.0, 1111.0, 525.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
29 2 9 text nsPEFs downregulate glycosaminoglycan (GAG) production. Results obtained demonstrated that nsPEFs at 10 kV/cm decreased GAG production at day 1 (0.91-fold), day 3 (0.96-fold) and day 7 (0.97-fold). Mo [600.0, 538.0, 1111.0, 773.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
30 2 10 text nsPEFs downregulate expression of functional genes. Effects of nsPEFs on gene expression were evaluated at 1 hour and 24 hours [601.0, 784.0, 1112.0, 830.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
31 2 11 chart [232.0, 867.0, 581.0, 1110.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
32 2 12 figure_title b [611.0, 857.0, 636.0, 889.0] figure_inner_text 0.9 ["panel label / figure inner text: b"] figure_inner_text 0.9 display_zone legend_like panel_label True True
33 2 13 chart [610.0, 869.0, 954.0, 1108.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
34 2 14 chart [237.0, 1134.0, 581.0, 1378.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
35 2 15 chart [605.0, 1131.0, 954.0, 1377.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
36 2 16 figure_title Figure 2 | Induction of dedifferentiated phenotype of chondrocytes after nsPEF treatment. (a) The toxicity of nsPEFs at 10 kV/cm and 20 kV/cm was evaluated at days 1, 3 and 7. nsPEFs had a nontoxic ef [80.0, 1388.0, 1110.0, 1497.0] figure_caption 0.95 ["Frontiers figure title pattern: Figure 2 | Induction of dedifferentiated phenotype of chondr"] figure_caption 0.95 display_zone legend_like figure_number True True
37 2 17 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [82.0, 1520.0, 518.0, 1542.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
38 2 18 number 2 [1092.0, 1522.0, 1110.0, 1541.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
39 3 0 header www.nature.com/scientificreports [761.0, 30.0, 1109.0, 54.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
40 3 1 header_image [1125.0, 1.0, 1191.0, 75.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 body_zone unknown_like empty False True
41 3 2 figure_title a [218.0, 112.0, 242.0, 137.0] figure_inner_text 0.9 ["panel label / figure inner text: a"] figure_inner_text 0.9 display_zone legend_like panel_label True True
42 3 3 chart [219.0, 114.0, 581.0, 369.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
43 3 4 figure_title b [606.0, 105.0, 630.0, 137.0] figure_inner_text 0.9 ["panel label / figure inner text: b"] figure_inner_text 0.9 display_zone legend_like panel_label True True
44 3 5 chart [606.0, 110.0, 976.0, 368.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
45 3 6 figure_title C [218.0, 387.0, 241.0, 414.0] figure_inner_text 0.9 ["panel label / figure inner text: C"] figure_inner_text 0.9 display_zone legend_like panel_label True True
46 3 7 chart [220.0, 389.0, 582.0, 641.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
47 3 8 chart [607.0, 383.0, 976.0, 642.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
48 3 9 figure_title e [216.0, 656.0, 242.0, 682.0] figure_inner_text 0.9 ["panel label / figure inner text: e"] figure_inner_text 0.9 display_zone legend_like panel_label True True
49 3 10 chart [211.0, 666.0, 580.0, 911.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
50 3 11 figure_title Figure 3 | Functional gene expression of chondrocytes after nsPEF treatment. Gene expression was analyzed at 1 hour for immediate effects and following a recovery period of 24 hours after 10 kV/cm and [78.0, 924.0, 1107.0, 1011.0] figure_caption 0.95 ["Frontiers figure title pattern: Figure 3 | Functional gene expression of chondrocytes after "] figure_caption 0.95 display_zone legend_like figure_number True True
51 3 12 text after nsPEF treatment. At 1 hour, nsPEFs at 10 kV/cm decreased gene expression of COL II significantly to 0.43-fold (p = 0.017), while nsPEFs at 20 kV/cm decreased COL II gene expression to 0.45-fold [79.0, 1033.0, 588.0, 1286.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
52 3 13 text At 24 hours after nsPEF treatment, gene expression showed an increase compared to the gene expression at 1 hour. An additive effect of COL I was indicated by an increase in the gene expression to 1.75 [79.0, 1287.0, 588.0, 1434.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
53 3 14 text nsPEFs activate wnt/β-catenin signaling pathway. Expression of β-catenin protein increased significantly by 45% (p = 0.005) and 42% (p = 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment, resp [80.0, 1453.0, 588.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
54 3 15 text (p 5 0.006) 1 hour after 10 kV/cm and 20 kV/cm nsPEF treatment, respectively (Fig. 4a, b). As shown, b-catenin accumulated in the nucleus of the cells after nsPEF treatment (Fig. 4c). 10 kV/cm and 20 [601.0, 1033.0, 1111.0, 1288.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
55 3 16 text Our findings demonstrated that after 24 hours, nsPEFs induced a decrease in Lef1 and c-jun gene expression in comparison to the gene expression observed after 1 hour. nsPEFs increased gene expression [601.0, 1287.0, 1111.0, 1433.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
56 3 17 text Inhibition of wnt/ $ \beta $-catenin pathway partially blocks effects of nsPEFs. Incubation with XAV939 reverted nsPEF-induced upregulation of $ \beta $- [601.0, 1453.0, 1109.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
57 3 18 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [82.0, 1521.0, 517.0, 1542.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
58 3 19 number 3 [1093.0, 1523.0, 1109.0, 1541.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
59 4 0 header www.nature.com/scientificreports [761.0, 31.0, 1109.0, 53.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
60 4 1 header_image [1126.0, 1.0, 1191.0, 75.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 body_zone unknown_like empty False True
61 4 2 chart [109.0, 114.0, 324.0, 272.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
62 4 3 chart [364.0, 103.0, 577.0, 322.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
63 4 4 image [102.0, 333.0, 550.0, 760.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
64 4 5 figure_title Figure 4 | Activated wnt/β-catenin signaling pathway after nsPEF treatment. (a) β-catenin protein expression performed with western blotting analysis using specific antibodies for β-catenin at 1 hour [80.0, 776.0, 588.0, 966.0] figure_caption 0.95 ["Frontiers figure title pattern: Figure 4 | Activated wnt/\u03b2-catenin signaling pathway after n"] figure_caption 0.95 display_zone legend_like figure_number True True
65 4 6 text catenin (Fig. 6j–6l), wnt7a gene (Fig. 6d) and the downstream genes of wnt, Lef1 (Fig. 6a), c-jun (Fig. 6b) and cyclin D1 (Fig. 6c) by inhibition ranging from 30% to 60%. When the effects of inhibitio [79.0, 989.0, 588.0, 1307.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
66 4 7 paragraph_title Discussion [81.0, 1326.0, 190.0, 1347.0] section_heading 0.9 ["explicit scholarly heading: Discussion"] section_heading 0.9 body_zone heading_like canonical_section_name True True
67 4 8 text nsPEFs have profound effects on multiple organelles of a cell. nsPEFs generate large transmembrane potentials across cellular organelles with limited thermal effects. The most significant characterist [79.0, 1348.0, 589.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
68 4 9 text pulse duration decreases, the outer membrane is likely shorted, and the applied voltage appears mainly across the interior organelles of the cell27. nsPEFs modify the potential and phosphatidylserine [602.0, 100.0, 1112.0, 312.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
69 4 10 text Effects of nsPEFs are usually transient. Typically, the nanopores can be formed within 5 nanoseconds after nsPEF treatment $ ^{7} $. Calcium ions efflux from the endoplasmic reticulum within 10 second [601.0, 314.0, 1111.0, 630.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
70 4 11 text Fine-tuned activation of the wnt/β-catenin signaling pathway is essential to regulate the fate of chondrocytes in cartilage. The wnt/β-catenin pathway is involved in dedifferentiation of cultured chon [602.0, 629.0, 1111.0, 1074.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
71 4 12 text The fact that inhibition of the wnt/ $ \beta $-catenin signaling can only partially block the effects of nsPEFs on chondrocytes hints that there are other mechanisms involved. The functional crosstalk [601.0, 1073.0, 1112.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
72 4 13 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [82.0, 1520.0, 517.0, 1542.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
73 4 14 number 4 [1093.0, 1523.0, 1109.0, 1541.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
74 5 0 header www.nature.com/scientificreports [761.0, 30.0, 1110.0, 54.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
75 5 1 header_image [1125.0, 1.0, 1191.0, 75.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 body_zone unknown_like empty False True
76 5 2 chart [251.0, 111.0, 587.0, 354.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
77 5 3 figure_title b [597.0, 104.0, 620.0, 136.0] figure_inner_text 0.9 ["panel label / figure inner text: b"] figure_inner_text 0.9 display_zone legend_like panel_label True True
78 5 4 chart [597.0, 111.0, 934.0, 353.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
79 5 5 chart [255.0, 370.0, 589.0, 613.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
80 5 6 figure_title d [597.0, 365.0, 622.0, 395.0] figure_inner_text 0.9 ["panel label / figure inner text: d"] figure_inner_text 0.9 display_zone legend_like panel_label True True
81 5 7 chart [593.0, 372.0, 935.0, 611.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
82 5 8 figure_title Figure 5 | Influence of nsPEFs on gene expression related to wnt/ $ \beta $-catenin signaling. Gene expression was detected immediately at 1 hour and following a 24 hour recovery after 0, 10 and 20 kV [80.0, 623.0, 1109.0, 688.0] figure_caption 0.95 ["Frontiers figure title pattern: Figure 5 | Influence of nsPEFs on gene expression related to"] figure_caption 0.95 display_zone legend_like figure_number True True
83 5 9 text due to its folded spiral structure, it is sensitive to nsPEFs and forms speckles after nsPEF treatment $ ^{28} $. nsPEFs induce small nuclear ribonucleoprotein particles and RNA-protein complexes, whi [79.0, 710.0, 588.0, 987.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
84 5 10 text nsPEFs may have different effects on suspended and attached cells in vitro. Cells in a suspended state were subjected to nsPEFs within electric cuvettes, which provided an instantaneous and consistent [79.0, 987.0, 589.0, 1499.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
85 5 11 text development of a real-time visual microfluidic system for monitoring adherent cells combined with nsPEFs52. [601.0, 710.0, 1110.0, 753.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
86 5 12 text As nsPEFs do not exist in a natural cellular environment, a comprehensive understanding of nsPEFs as well as the effects of superficial stimuli need to be further explored to determine any difference [600.0, 756.0, 1112.0, 1011.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
87 5 13 paragraph_title Methods [603.0, 1042.0, 696.0, 1064.0] section_heading 0.9 ["explicit scholarly heading: Methods"] section_heading 0.9 body_zone heading_like canonical_section_name True True
88 5 14 text Cell culture. Porcine articular cartilage tissue was cut into small pieces by a lancet, and washed with phosphate-buffered saline (PBS). The tissue pieces were collected and digested in 0.1% Collagena [601.0, 1069.0, 1110.0, 1313.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
89 5 15 text Application of nsPEFs. The nsPEF generator was applied as previously described $ ^{54} $. Digital phosphor oscilloscope (DPO4054, Tektronix) with a probe (P6015A, Tektronix) was utilized to monitor th [601.0, 1339.0, 1112.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
90 5 16 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [82.0, 1521.0, 517.0, 1542.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
91 5 17 number 5 [1093.0, 1523.0, 1108.0, 1541.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
92 6 0 header www.nature.com/scientificreports [762.0, 30.0, 1109.0, 53.0] noise 0.9 ["header label"] noise 0.9 body_zone body_like none False False
93 6 1 header_image [1125.0, 1.0, 1190.0, 75.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 body_zone unknown_like empty False True
94 6 2 chart [102.0, 104.0, 287.0, 319.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
95 6 3 chart [302.0, 112.0, 493.0, 320.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
96 6 4 chart [500.0, 111.0, 701.0, 319.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
97 6 5 chart [703.0, 113.0, 899.0, 319.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
98 6 6 chart [902.0, 119.0, 1101.0, 320.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
99 6 7 chart [89.0, 344.0, 289.0, 545.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
100 6 8 chart [294.0, 342.0, 494.0, 545.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
101 6 9 chart [502.0, 344.0, 704.0, 544.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
102 6 10 chart [717.0, 341.0, 918.0, 544.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
103 6 11 figure_title j [105.0, 571.0, 120.0, 602.0] figure_inner_text 0.9 ["panel label / figure inner text: j"] figure_inner_text 0.9 display_zone legend_like panel_label True True
104 6 12 image [101.0, 569.0, 352.0, 778.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
105 6 13 chart [376.0, 573.0, 578.0, 788.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
106 6 14 chart [611.0, 561.0, 860.0, 796.0] figure_asset 0.85 ["media label: chart"] media_asset 0.85 body_zone unknown_like empty True True
107 6 15 image [612.0, 559.0, 1065.0, 796.0] figure_asset 0.85 ["media label: image"] media_asset 0.85 body_zone unknown_like empty True True
108 6 16 figure_title Figure 6 | Influence of inhibition of wnt/ $ \beta $-catenin signaling on gene and protein expression after nsPEF treatment. Gene expression was detected at 1 hour after 0, 10 and 20 kV/cm nsPEF treat [77.0, 812.0, 1112.0, 960.0] figure_caption 0.95 ["Frontiers figure title pattern: Figure 6 | Influence of inhibition of wnt/ $ \\beta $-catenin"] figure_caption 0.95 display_zone legend_like figure_number True True
109 6 17 text Celltoxicity. The toxicity of nsPEFs was evaluated by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT, M2128, Sigma) at days 1, 3 and 7.5.0 × 10³ chondrocytes/well were seeded in [80.0, 982.0, 589.0, 1121.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
110 6 18 text Cell proliferation. Cell proliferation was assayed with Hoechst 33258 (H6024, Sigma) at days 1, 3 and 7. Chondrocytes in each well were lysed with 100 μL sterile distilled DNAse-free H₂O, and the diss [80.0, 1135.0, 587.0, 1258.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
111 6 19 text GAG content. Chondrocytes were digested in 0.5 mg/mL proteinase K at 56°C for 12 hours, and were subsequently examined with dimethylmethylene blue (DMMB, 341088, Sigma). The digestive solution was sha [79.0, 1272.0, 587.0, 1396.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
112 6 20 text Gene expression. Total RNA was extracted and isolated from chondrocytes with Trizol Reagent (206101, New Industry) following the standard protocol, and quantified with Nanodrop spectrophotometer (ND-1 [80.0, 1409.0, 588.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
113 6 21 text cycler (Mycycler, Bio-Rad). Quantitative real-time PCR was performed in the PCR system (Pikoreal 96, Thermo) with RealMasterMix SYBR Green (FP202, Tiangen) following the manufacturer’s procedures. The [601.0, 982.0, 1111.0, 1374.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
114 6 22 text Western blotting. Chondrocytes were lysed by RIPA lysis buffer (R0020, Solarbio) with fresh protease inhibitor of 0.1% phenylmethanesulfonyl fluoride (PMSF, Solarbio). Total cell lysate was boiled aft [602.0, 1391.0, 1108.0, 1498.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
115 6 23 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [82.0, 1521.0, 517.0, 1542.0] noise 0.9 ["footer label"] noise 0.9 body_zone body_like none False False
116 6 24 number 6 [1093.0, 1523.0, 1109.0, 1541.0] noise 0.9 ["page number label"] noise 0.9 body_zone body_like short_fragment False False
117 7 0 header www.nature.com/scientificreports [761.0, 31.0, 1109.0, 53.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
118 7 1 header_image [1125.0, 1.0, 1190.0, 74.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 unknown_like empty False True
119 7 2 text and $ \beta $-actin (4970, Cell Signaling) was combined with HRP-linked antibody of anti-rabbit IgG (7074, Cell Signaling). The complex of the antigen and the antibody was illuminated by chemilumines [89.0, 98.0, 591.0, 171.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
120 7 3 text Immunofluorescence. Immunofluorescence was utilized to confirm the location of $ \beta $-catenin protein. After nsPEF treatment, chondrocytes were fixed with 4% paraformaldehyde for 15 minutes and wa [81.0, 189.0, 586.0, 329.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
121 7 4 text Statistical analysis. Analysis was performed using SPSS V13.0 (SPSS Inc.) one-way ANOVA with the least significant difference (LSD) test (data presented as mean ± s.d). The statistical significance wa [81.0, 348.0, 585.0, 419.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 body_zone body_like none True True
122 7 5 reference_content 1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Membrane electroporation theories: a review. Med. Biol. Eng. Comput. 44, 5–14 (2006). [82.0, 452.0, 586.0, 486.0] reference_item 0.85 ["reference content label: 1. Chen, C., Smye, S. W., Robinson, M. P. & Evans, J. A. Mem"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
123 7 6 reference_content 2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Nanosecond Pulsed Electric Fields into He La Cells Expressing Enhanced Green Fluorescent Protein and Fluorescence Lifetime Microscopy. J. Phys [83.0, 487.0, 586.0, 553.0] reference_item 0.85 ["reference content label: 2. Awasthi, K., Nakabayashi, T. & Ohta, N. Application of Na"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
124 7 7 reference_content 3. Weaver, J. C. Electroporation of biological membranes from multicellular to nano scales. IEEE Trans. Dielectr. Electr. Insul. 10, 754–768 (2003). [83.0, 556.0, 587.0, 590.0] reference_item 0.85 ["reference content label: 3. Weaver, J. C. Electroporation of biological membranes fro"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
125 7 8 reference_content 4. Schoenbach, K. H. et al. Ultrashort electrical pulses open a new gateway into biological cells. Proc. IEEE 92, 1122–1137 (2004). [84.0, 592.0, 571.0, 626.0] reference_item 0.85 ["reference content label: 4. Schoenbach, K. H. et al. Ultrashort electrical pulses ope"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
126 7 9 reference_content 5. Silve, A., Leray, I. & Mir, L. M. Demonstration of cell membrane permeabilization to medium-sized molecules caused by a single 10 ns electric pulse. Bioelectrochemistry 87, 260–264 (2012). [83.0, 627.0, 586.0, 675.0] reference_item 0.85 ["reference content label: 5. Silve, A., Leray, I. & Mir, L. M. Demonstration of cell m"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
127 7 10 reference_content 6. Rems, L. et al. Cell electrofusion using nanosecond electric pulses. Sci. Rep. 3, 3382; doi:10.1038/srep03382 (2013). [84.0, 678.0, 587.0, 712.0] reference_item 0.85 ["reference content label: 6. Rems, L. et al. Cell electrofusion using nanosecond elect"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
128 7 11 reference_content 7. Hu, Q., Joshi, R. P. & Schoenbach, K. H. Simulations of nanopore formation and phosphatidylserine externalization in lipid membranes subjected to a high-intensity, ultrashort electric pulse. Phys. [83.0, 713.0, 586.0, 765.0] reference_item 0.85 ["reference content label: 7. Hu, Q., Joshi, R. P. & Schoenbach, K. H. Simulations of n"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
129 7 12 reference_content 8. Schoenbach, K. H., Beebe, S. J. & Buescher, E. S. Intracellular effect of ultrashort electrical pulses. Bioelectromagnetics 22, 440–448 (2001). [83.0, 765.0, 586.0, 799.0] reference_item 0.85 ["reference content label: 8. Schoenbach, K. H., Beebe, S. J. & Buescher, E. S. Intrace"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
130 7 13 reference_content 9. White, J. A., Blackmore, P. F., Schoenbach, K. H. & Beebe, S. J. Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields. J. Biol. Chem. 279, 22964–22972 (2004 [84.0, 801.0, 577.0, 851.0] reference_item 0.85 ["reference content label: 9. White, J. A., Blackmore, P. F., Schoenbach, K. H. & Beebe"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
131 7 14 reference_content 10. Morotomi-Yano, K., Akiyama, H. & Yano, K. Nanosecond pulsed electric fields activate MAPK pathways in human cells. Arch. Biochem. Biophys. 515, 99–106 (2011). [85.0, 852.0, 583.0, 903.0] reference_item 0.85 ["reference content label: 10. Morotomi-Yano, K., Akiyama, H. & Yano, K. Nanosecond pul"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
132 7 15 reference_content 11. Garon, E. B. et al. In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies. Int. J. Cancer 121, 675–682 (2007). [84.0, 905.0, 585.0, 956.0] reference_item 0.85 ["reference content label: 11. Garon, E. B. et al. In vitro and in vivo evaluation and "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
133 7 16 reference_content 12. Ren, W., Sain, N. M. & Beebe, S. J. Nanosecond pulsed electric fields (nsPEFs) activate intrinsic caspase-dependent and caspase-independent cell death in Jurkat cells. Biochem. Biophys. Res. Commu [85.0, 957.0, 586.0, 1008.0] reference_item 0.85 ["reference content label: 12. Ren, W., Sain, N. M. & Beebe, S. J. Nanosecond pulsed el"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
134 7 17 reference_content 13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. & Stacey, M. W. Enhanced Killing Effect of Nanosecond Pulse Electric Fields on PANC1 and Jurkat Cell Lines in the Presence of Tween 80. The [85.0, 1010.0, 587.0, 1076.0] reference_item 0.85 ["reference content label: 13. Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
135 7 18 reference_content 14. van der Kraan, P. M., Davidson, E. N. B., Blom, A. & van den Berg, W. B. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis Modulation and integration of signaling pathw [84.0, 1079.0, 585.0, 1146.0] reference_item 0.85 ["reference content label: 14. van der Kraan, P. M., Davidson, E. N. B., Blom, A. & van"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
136 7 19 reference_content 15. Grimsrud, C. D. et al. BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog. Journal of Orthopaedic Research 19, 18–25 (2001). [85.0, 1148.0, 587.0, 1183.0] reference_item 0.85 ["reference content label: 15. Grimsrud, C. D. et al. BMP signaling stimulates chondroc"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
137 7 20 reference_content 16. Riemer, S., Gebhard, S., Beier, F., Poschl, E. & von der Mark, K. Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: Localization of a PTH/PTHrP-responsive region [85.0, 1184.0, 588.0, 1250.0] reference_item 0.85 ["reference content label: 16. Riemer, S., Gebhard, S., Beier, F., Poschl, E. & von der"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
138 7 21 reference_content 17. Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocyte phenotype by beta-catenin. Mol Biol Cell 13, 118a–118a (2002). [85.0, 1252.0, 575.0, 1287.0] reference_item 0.85 ["reference content label: 17. Ryu, J., Kang, S. & Chun, J. Regulation of the chondrocy"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
139 7 22 reference_content 18. Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. Chem. 280, 21653–21660 (2 [85.0, 1289.0, 586.0, 1338.0] reference_item 0.85 ["reference content label: 18. Lyu, J. & Joo, C. K. Wnt-7a up-regulates matrix metallop"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
140 7 23 reference_content 19. Fini, M. et al. Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation? Tissue Eng Part B-Re 19, 353–367 (2013). [85.0, 1340.0, 588.0, 1389.0] reference_item 0.85 ["reference content label: 19. Fini, M. et al. Functional Tissue Engineering in Articul"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
141 7 24 reference_content 20. Macginitie, L. A., Gluzband, Y. A. & Grodzinsky, A. J. Electric-Field Stimulation Can Increase Protein-Synthesis in Articular-Cartilage Explants. Journal of Orthopaedic Research 12, 151–160 (1994) [84.0, 1392.0, 585.0, 1443.0] reference_item 0.85 ["reference content label: 20. Macginitie, L. A., Gluzband, Y. A. & Grodzinsky, A. J. E"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
142 7 25 reference_content 21. Lippiello, L., Chakkalakal, D. & Connolly, J. F. Pulsing Direct Current-Induced Repair of Articular-Cartilage in Rabbit Osteochondral Defects. Journal of Orthopaedic Research 8, 266–275 (1990). [84.0, 1444.0, 581.0, 1495.0] reference_item 0.85 ["reference content label: 21. Lippiello, L., Chakkalakal, D. & Connolly, J. F. Pulsing"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
143 7 26 reference_content 22. Wang, W., Wang, Z. Y., Zhang, G. H., Clark, C. C. & Brighton, C. T. Up-regulation of chondrocyte matrix genes and products by electric fields. Clin Orthop Relat R, S163–S173 (2004). [604.0, 101.0, 1108.0, 150.0] reference_item 0.85 ["reference content label: 22. Wang, W., Wang, Z. Y., Zhang, G. H., Clark, C. C. & Brig"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
144 7 27 reference_content 23. Morotomi-Yano, K., Oyadomari, S., Akiyama, H. & Yano, K. Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2 alpha phosphory [604.0, 151.0, 1108.0, 219.0] reference_item 0.85 ["reference content label: 23. Morotomi-Yano, K., Oyadomari, S., Akiyama, H. & Yano, K."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
145 7 28 reference_content 24. Ge, Z. G., Baguenard, S., Lim, L. Y., Wee, A. & Khor, E. Hydroxyapatite-chitin materials as potential tissue engineered bone substitutes. Biomaterials 25, 1049–1058 (2004). [606.0, 219.0, 1100.0, 269.0] reference_item 0.85 ["reference content label: 24. Ge, Z. G., Baguenard, S., Lim, L. Y., Wee, A. & Khor, E."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
146 7 29 reference_content 25. Schoenbach, K. H., Katsuki, S., Stark, R. H., Buescher, E. S. & Beebe, S. J. Bioelectrics - New applications for pulsed power technology. IEEE Trans. Plasma Sci. 30, 293–300 (2002). [606.0, 271.0, 1109.0, 320.0] reference_item 0.85 ["reference content label: 25. Schoenbach, K. H., Katsuki, S., Stark, R. H., Buescher, "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
147 7 30 reference_content 26. Frey, W. et al. Plasma membrane voltage changes during nanosecond pulsed electric field exposure. Biophysical Journal 90, 3608–3615 (2006). [604.0, 324.0, 1098.0, 354.0] reference_item 0.85 ["reference content label: 26. Frey, W. et al. Plasma membrane voltage changes during n"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
148 7 31 reference_content 27. Ellappan, P. & Sundararajan, R. A simulation study of the electrical model of a biological cell. J. Electrost. 63, 297–307 (2005). [605.0, 356.0, 1105.0, 389.0] reference_item 0.85 ["reference content label: 27. Ellappan, P. & Sundararajan, R. A simulation study of th"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
149 7 32 reference_content 28. Stacey, M. et al. Differential effects in cells exposed to ultra-short, high intensity electric fields: cell survival, DNA damage, and cell cycle analysis. Mutat Res-Gen Tox En 542, 65–75 (2003). [606.0, 391.0, 1108.0, 439.0] reference_item 0.85 ["reference content label: 28. Stacey, M. et al. Differential effects in cells exposed "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
150 7 33 reference_content 29. Chen, N. Y. et al. Nanosecond electric pulses penetrate the nucleus an enhance speckle formation. Biochem. Biophys. Res. Commun. 364, 220–225 (2007). [607.0, 441.0, 1104.0, 474.0] reference_item 0.85 ["reference content label: 29. Chen, N. Y. et al. Nanosecond electric pulses penetrate "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
151 7 34 reference_content 30. Pakhomova, O. N. et al. Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media. Arch. Biochem. Biophys. 527, 55–64 (2012). [606.0, 476.0, 1106.0, 509.0] reference_item 0.85 ["reference content label: 30. Pakhomova, O. N. et al. Oxidative effects of nanosecond "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
152 7 35 reference_content 31. Zhang, J. et al. Nanosecond pulse electric field (nanopulse): A novel non-ligand agonist for platelet activation. Arch. Biochem. Biophys. 471, 240–248 (2008). [607.0, 508.0, 1106.0, 543.0] reference_item 0.85 ["reference content label: 31. Zhang, J. et al. Nanosecond pulse electric field (nanopu"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
153 7 36 reference_content 32. Beebe, S. J., Blackmore, P. F., White, J., Joshi, R. P. & Schoenbach, K. H. Nanosecond pulsed electric fields modulate cell function through intracellular signal transduction mechanisms. Physiol M [605.0, 544.0, 1099.0, 594.0] reference_item 0.85 ["reference content label: 32. Beebe, S. J., Blackmore, P. F., White, J., Joshi, R. P. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
154 7 37 reference_content 33. Hwang, S. G., Yu, S. S., Poo, H. & Chun, J. S. c-Jun/activator protein-1 mediates interleukin-1 beta-induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. J. Bio [606.0, 594.0, 1109.0, 643.0] reference_item 0.85 ["reference content label: 33. Hwang, S. G., Yu, S. S., Poo, H. & Chun, J. S. c-Jun/act"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
155 7 38 reference_content 34. Novak, A. & Dedhar, S. Signaling through beta-catenin and Lef/Tcf. Cellular and Molecular Life Sciences 56, 523–537 (1999). [606.0, 645.0, 1110.0, 678.0] reference_item 0.85 ["reference content label: 34. Novak, A. & Dedhar, S. Signaling through beta-catenin an"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
156 7 39 reference_content 35. Shtutman, M. et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. P Natl Acad Sci USA 96, 5522–5527 (1999). [607.0, 679.0, 1085.0, 712.0] reference_item 0.85 ["reference content label: 35. Shtutman, M. et al. The cyclin D1 gene is a target of th"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
157 7 40 reference_content 36. Hwang, S. G., Yu, S. S., Lee, S. W. & Chun, J. S. Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway. Feb 579, 4837–4842 (2005). [606.0, 713.0, 1101.0, 746.0] reference_item 0.85 ["reference content label: 36. Hwang, S. G., Yu, S. S., Lee, S. W. & Chun, J. S. Wnt-3a"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
158 7 41 reference_content 37. Beebe, S. J., Fox, P. M., Rec, L. J., Willis, L. K. & Schoenbach, K. H. Nanosecond, high-intensity pulsed electric fields induce apoptosis in human cells. Faseb J 17, 1493–+ (2003). [607.0, 747.0, 1107.0, 796.0] reference_item 0.85 ["reference content label: 37. Beebe, S. J., Fox, P. M., Rec, L. J., Willis, L. K. & Sc"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
159 7 42 reference_content 38. Bell, D. M. et al. SOX9 directly regulates the type-II collagen gene. Nat Genet 16, 174–178 (1997). [606.0, 798.0, 1107.0, 831.0] reference_item 0.85 ["reference content label: 38. Bell, D. M. et al. SOX9 directly regulates the type-II c"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
160 7 43 reference_content 39. de Crombrugghe, B. et al. Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol 19, 389–394 (2000). [606.0, 832.0, 1055.0, 865.0] reference_item 0.85 ["reference content label: 39. de Crombrugghe, B. et al. Transcriptional mechanisms of "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
161 7 44 reference_content 40. Ryu, J. H. et al. Regulation of the chondrocyte phenotype by beta-catenin. Development 129, 5541–5550 (2002). [607.0, 867.0, 1073.0, 899.0] reference_item 0.85 ["reference content label: 40. Ryu, J. H. et al. Regulation of the chondrocyte phenotyp"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
162 7 45 reference_content 41. Zhu, M. et al. Activation of beta-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult beta-Catenin Conditional Activation Mice. J Bone Miner Res 24, 12–21 ( [606.0, 901.0, 1097.0, 950.0] reference_item 0.85 ["reference content label: 41. Zhu, M. et al. Activation of beta-Catenin Signaling in A"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
163 7 46 reference_content 42. Zhu, M. et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum. 58, 2053–2064 (2008). [606.0, 951.0, 1109.0, 985.0] reference_item 0.85 ["reference content label: 42. Zhu, M. et al. Inhibition of beta-catenin signaling in a"] reference_item 0.85 reference_zone unknown_like heading_numbered True True
164 7 47 reference_content 43. Ibey, B. L. et al. Dose-Dependent Thresholds of 10-ns Electric Pulse Induced Plasma Membrane Disruption and Cytotoxicity in Multiple Cell Lines. PLoS One 6 (2011). [606.0, 986.0, 1109.0, 1034.0] reference_item 0.85 ["reference content label: 43. Ibey, B. L. et al. Dose-Dependent Thresholds of 10-ns El"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
165 7 48 reference_content 44. Morotomi-Yano, K., Uemura, Y., Katsuki, S., Akiyama, H. & Yano, K. Activation of the JNK pathway by nanosecond pulsed electric fields. Biochem. Biophys. Res. Commun. 408, 471–476 (2011). [606.0, 1037.0, 1107.0, 1086.0] reference_item 0.85 ["reference content label: 44. Morotomi-Yano, K., Uemura, Y., Katsuki, S., Akiyama, H. "] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
166 7 49 reference_content 45. Scarlett, S. S., White, J. A., Blackmore, P. F., Schoenbach, K. H. & Kolb, J. F. Regulation of intracellular calcium concentration by nanosecond pulsed electric fields. Biochim. Biophys. Acta-Biom [606.0, 1088.0, 1106.0, 1137.0] reference_item 0.85 ["reference content label: 45. Scarlett, S. S., White, J. A., Blackmore, P. F., Schoenb"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
167 7 50 reference_content 46. Nutt, L. K. et al. Bax-mediated Ca $ ^{2+} $ mobilization promotes cytochrome c release during apoptosis. J. Biol. Chem. 277, 20301–20308 (2002). [607.0, 1139.0, 1108.0, 1173.0] reference_item 0.85 ["reference content label: 46. Nutt, L. K. et al. Bax-mediated Ca $ ^{2+} $ mobilizatio"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
168 7 51 reference_content 47. Lin, J. C. Microwave Auditory Phenomenon. Proc. IEEE 68, 67–73 (1980). [605.0, 1173.0, 1077.0, 1189.0] reference_item 0.85 ["reference content label: 47. Lin, J. C. Microwave Auditory Phenomenon. Proc. IEEE 68,"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
169 7 52 reference_content 48. Pakhomov, A. G. et al. Long-lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric field (nsPEF). Bioelectromagnetics 28, 655–663 (2007). [607.0, 1190.0, 1081.0, 1239.0] reference_item 0.85 ["reference content label: 48. Pakhomov, A. G. et al. Long-lasting plasma membrane perm"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
170 7 53 reference_content 49. Kirawanich, P., Pausawasdi, N., Srisawat, C., Yakura, S. J. & Islam, N. E. An FDTD Interaction Scheme of a High-Intensity Nanosecond-Pulsed Electric-Field System for In Vitro Cell Apoptosis Applic [606.0, 1241.0, 1108.0, 1306.0] reference_item 0.85 ["reference content label: 49. Kirawanich, P., Pausawasdi, N., Srisawat, C., Yakura, S."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
171 7 54 reference_content 50. Wang, N., Butler, J. P. & Ingber, D. E. Mechanotransduction across the Cell-Surface and through the Cytoskeleton. Science 260, 1124–1127 (1993). [606.0, 1308.0, 1090.0, 1342.0] reference_item 0.85 ["reference content label: 50. Wang, N., Butler, J. P. & Ingber, D. E. Mechanotransduct"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
172 7 55 reference_content 51. Thompson, G. L., Roth, C., Tolstykh, G., Kuipers, M. & Ibey, B. L. Role of Cytoskeleton and Elastic Moduli in Cellular Response to Nanosecond Pulsed Electric Fields. Proc Spie 8585 (2013). [606.0, 1343.0, 1092.0, 1392.0] reference_item 0.85 ["reference content label: 51. Thompson, G. L., Roth, C., Tolstykh, G., Kuipers, M. & I"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
173 7 56 reference_content 52. Dalmay, C., De Menorval, M. A., Francais, O., Mir, L. M. & Le Pioufle, B. A microfluidic device with removable packaging for the real time visualisation of intracellular effects of nanosecond elec [605.0, 1394.0, 1108.0, 1460.0] reference_item 0.85 ["reference content label: 52. Dalmay, C., De Menorval, M. A., Francais, O., Mir, L. M."] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
174 7 57 reference_content 53. Beebe, S. J. Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs). Int J Nanomed 8 (2013). [606.0, 1462.0, 1108.0, 1494.0] reference_item 0.85 ["reference content label: 53. Beebe, S. J. Cell responses without receptors and ligand"] reference_item 0.85 reference_zone reference_like reference_numeric_dot True True
175 7 58 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [83.0, 1521.0, 517.0, 1541.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False
176 7 59 number 7 [1093.0, 1523.0, 1108.0, 1540.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False
177 8 0 header www.nature.com/scientificreports [762.0, 31.0, 1109.0, 53.0] noise 0.9 ["header label"] noise 0.9 unknown_like none False False
178 8 1 header_image [1126.0, 1.0, 1190.0, 74.0] unknown_structural 0.2 ["unrecognized label 'header_image'"] unknown_structural 0.2 unknown_like empty False True
179 8 2 text 54. Wang, J. et al. Synergistic Effects of Nanosecond Pulsed Electric Fields Combined with Low Concentration of Gemcitabine on Human Oral Squamous Cell Carcinoma In Vitro. PLoS One 7 (2012). [82.0, 99.0, 587.0, 153.0] reference_item 0.6 ["reference-like pattern: 54. Wang, J. et al. Synergistic Effects of Nanosecond Pulsed"] reference_item 0.6 reference_zone reference_like reference_numeric_dot True True
180 8 3 paragraph_title Acknowledgments [82.0, 198.0, 270.0, 220.0] sub_subsection_heading 0.6 ["unnumbered paragraph_title, inferred level sub_subsection_heading: Acknowledgments"] sub_subsection_heading 0.6 tail_nonref_hold_zone heading_like short_fragment True True
181 8 4 text This work was supported by National Basic Research Program of China (973 Program) (2012CB619100), and National Natural Science Foundation of China grant (81271722). The authors would like to thank A. [80.0, 220.0, 587.0, 291.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none True True
182 8 5 paragraph_title Author contributions [81.0, 313.0, 286.0, 333.0] unknown_structural 0.6 ["unnumbered paragraph_title, inferred level subsection_heading: Author contributions"] subsection_heading 0.6 tail_nonref_hold_zone support_like none False True
183 8 6 text Z.G. and J.Z. designed this study, whereas K.Z. and J.G. were involved in the experimentation. K.Z. and Z.G. analyzed data and wrote the manuscript with assistance from J.G. and J.Z. All authors revie [81.0, 334.0, 578.0, 388.0] body_paragraph 0.6 ["default body_paragraph for text label"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none True True
184 8 7 paragraph_title Additional information [604.0, 100.0, 829.0, 122.0] backmatter_heading 0.5 ["backmatter boundary candidate: Additional information"] backmatter_boundary_candidate 0.5 heading_like none True True
185 8 8 text Supplementary information accompanies this paper at http://www.nature.com/scientificreports [602.0, 122.0, 1057.0, 158.0] backmatter_body 0.6 ["default body_paragraph for text label", "tail_nonref_hold_zone excluded from body flow"] backmatter_body 0.6 tail_nonref_hold_zone unknown_like none True True
186 8 9 text Competing financial interests: The authors declare no competing financial interests. [602.0, 163.0, 1083.0, 181.0] backmatter_body 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none True True
187 8 10 text How to cite this article: Zhang, K., Guo, J., Ge, Z. & Zhang, J. Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/ $ \beta $-catenin Signaling Pathway. Sci. R [602.0, 186.0, 1108.0, 241.0] frontmatter_noise 0.8 ["frontmatter phrase: How to cite this article: Zhang, K., Guo, J., Ge, Z. & Zhang"] frontmatter_noise 0.8 unknown_like none False False
188 8 11 text This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, u [685.0, 258.0, 1111.0, 365.0] backmatter_body 0.6 ["default body_paragraph for text label", "promoted in tail spread from body_paragraph"] body_paragraph 0.6 tail_nonref_hold_zone unknown_like none True True
189 8 12 image [605.0, 261.0, 683.0, 290.0] media_asset 0.85 ["media label: image"] media_asset 0.85 unknown_like empty True True
190 8 13 footer SCIENTIFIC REPORTS | 4:5836 | DOI: 10.1038/srep05836 [82.0, 1520.0, 517.0, 1542.0] noise 0.9 ["footer label"] noise 0.9 unknown_like none False False
191 8 14 number 8 [1093.0, 1522.0, 1109.0, 1541.0] noise 0.9 ["page number label"] noise 0.9 unknown_like short_fragment False False

103
audit/2H8MZ27H/figure_table_ownership_summary.json Normal file
View file

@ -0,0 +1,103 @@
{
"figures": {
"matched_count": 5,
"ambiguous_count": 1,
"unresolved_cluster_count": 0,
"unmatched_asset_count": 2,
"matched": [
{
"figure_number": 2,
"legend_block_id": 16,
"asset_block_ids": [
11,
13,
15,
14
],
"page": 2,
"match_type": null
},
{
"figure_number": 3,
"legend_block_id": 11,
"asset_block_ids": [
5,
3,
8,
7,
10
],
"page": 3,
"match_type": null
},
{
"figure_number": 4,
"legend_block_id": 5,
"asset_block_ids": [
3,
2,
4
],
"page": 4,
"match_type": null
},
{
"figure_number": 5,
"legend_block_id": 8,
"asset_block_ids": [
2,
4,
5,
7
],
"page": 5,
"match_type": null
},
{
"figure_number": 6,
"legend_block_id": 16,
"asset_block_ids": [
2,
4,
3,
5,
6,
10,
8,
7,
9,
15,
14,
12,
13
],
"page": 6,
"match_type": null
}
],
"ambiguous": [
{
"figure_number": 1,
"legend_block_id": 3,
"asset_block_ids": [],
"candidate_asset_ids": [
2,
11,
11,
11,
14,
14
],
"page": 2
}
],
"unresolved": []
},
"tables": {
"matched_count": 0,
"ambiguous_count": 0,
"unmatched_asset_count": 0,
"matched": [],
"ambiguous": []
}
}

1317
audit/2H8MZ27H/fulltext_block_mapping_summary.json Normal file
View file

File diff suppressed because it is too large Load diff

212
audit/2H8MZ27H/page_risk_summary.json Normal file
View file

@ -0,0 +1,212 @@
{
"pages": [
{
"page": 1,
"risk_score": 7,
"risk_reasons": [
"frontmatter_page",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"frontmatter"
],
"counts": {
"body_paragraph": 3,
"reference_item": 0,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 2,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 2,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 5,
"table_like": 0,
"captions": 2,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 1,
"ambiguous_figures": 1
}
},
{
"page": 3,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 5,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 4,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 3,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 5,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 4,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 6,
"risk_score": 10,
"risk_reasons": [
"multi_asset_page",
"caption_asset_mismatch",
"reader_object_gap"
],
"recommended_audit_targets": [
"object_ownership"
],
"counts": {
"body_paragraph": 6,
"reference_item": 0,
"tail_like": 0,
"media_assets": 13,
"table_like": 0,
"captions": 1,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 1,
"ambiguous_figures": 0
}
},
{
"page": 7,
"risk_score": 8,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary"
],
"recommended_audit_targets": [
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 3,
"reference_item": 53,
"tail_like": 0,
"media_assets": 0,
"table_like": 0,
"captions": 0,
"hold": 0,
"unknown_structural": 1,
"matched_figures": 0,
"ambiguous_figures": 0
}
},
{
"page": 8,
"risk_score": 13,
"risk_reasons": [
"mixed_body_reference",
"same_page_boundary",
"reader_object_gap",
"unknown_structural_threshold"
],
"recommended_audit_targets": [
"body_flow",
"object_ownership",
"reading_order",
"reference_span",
"same_page_boundary"
],
"counts": {
"body_paragraph": 2,
"reference_item": 1,
"tail_like": 8,
"media_assets": 1,
"table_like": 0,
"captions": 0,
"hold": 1,
"unknown_structural": 2,
"matched_figures": 0,
"ambiguous_figures": 0
}
}
],
"selected_pages": [
1,
2,
3,
4,
5,
6,
7,
8
]
}

3
audit/2H8MZ27H/reference_intrusion_candidates.json Normal file
View file

@ -0,0 +1,3 @@
{
"candidates": []
}

12
audit/2H8MZ27H/reference_span_audit.json Normal file
View file

@ -0,0 +1,12 @@
{
"reference_span": {
"status": "HOLD",
"span_id": null,
"start": null,
"end": null,
"ordered_block_ids": [],
"inside_block_ids": [],
"explicitly_outside_nearby_block_ids": [],
"intrusion_candidates": []
}
}

523
audit/2HEUD5P9/audit_report.json Normal file
View file

@ -0,0 +1,523 @@
{
"paper_key": "2HEUD5P9",
"mode": "high-risk",
"status": "READY",
"focus": [],
"artifact_fingerprint": {
"result_json_hash": "sha256:228d05fc7b34c8528df7b30187f7c227618e92774fa2fc9828dd6986d8b66ba5",
"meta_json_hash": "sha256:1908715a6346b6c18f33636fe2da9eead16ef481869e28b11bb1ca75b3c0661b",
"blocks_raw_hash": "sha256:c9bf76e82e5fd66c3ef9cbf9fe91d3b35657c59a8f73890f281011ee4b548206",
"structured_blocks_hash": "sha256:2498b600a0edf0dfecf104198bc29998be9c93268135033d4a231274c116103d",
"document_structure_hash": "sha256:edb1ed86093e90f9bc9bf274fea8f7562836fd8a66c6afac831f2d3c4761635a",
"figure_inventory_hash": "sha256:d277bc958e0b13b52c8cf0fb53725897f8b3d9548c5e3702682da2f78b4f4b22",
"table_inventory_hash": "sha256:88ce3298727024ff4ef71d4cb1e703d2adf39a8440a4ae30415e3203c8caa162",
"reader_figures_hash": "sha256:e353d9969d61efe9f0c6f78d27493b318c1791975098fb1568b8e084bd05b04c",
"resolved_metadata_hash": "sha256:a112473490d63cea41837dd4de03988ed0909282253074ec28ff1546fdb3d4b3",
"fulltext_hash": "sha256:f6281fd010cb1d7cbbae8326ea6eaf4c5c3d7ac82c619b192336a7cba67846e6",
"block_trace_hash": "sha256:222f279ebf7ddc2f5a43068e7fa2b85d762ab24767ddfe9b552d4c8a2ce9d9e0",
"annotated_pages": {
"page_001.png": "sha256:a3cf4c5442d40caa83b31638b1f0c4d2ec21b709b9e59437b321ce48dc3ed7a9",
"page_002.png": "sha256:a3c835e2c3b0a2111e8e390faf9c857c2accba012fc6ad022f109f7fa9257c3a",
"page_003.png": "sha256:652026b489227e8b08aa37c05b23380bac80ad11dc29af127da400f1de87205b",
"page_004.png": "sha256:cce72745c1569a2571f1d40e0fa93c329fd2d22d796288c87e0508c6466ab423",
"page_005.png": "sha256:89350e7667220d4bb1deeb8bb77b8c9110715b3714a007c73499fdb6bc941fb0",
"page_006.png": "sha256:a8c252a325027451302557e6c24c551baeb59aa2430c143524bccc2f21a039a0",
"page_007.png": "sha256:40510447f60385d786bf25a5f330e06a1b1d77324ef55a1bdc5be349b368cf85",
"page_008.png": "sha256:eeb3f70a3ca9369f4e62baa939d7eaba9c5e07a119b7c92259ce4d2955ac8bf0",
"page_009.png": "sha256:761b92e156e6337ef263212370f3b505258a0a04586edaf0b52b715976b713dd",
"page_010.png": "sha256:1c305d948bc91a630ad9db063b3fd72fe05eafb841fc59d0f5c2e9d82bee19e9",
"page_011.png": "sha256:c061658f73d68979b3fd445e0a4795a15e22cb4428ec0d6630f709b63f7b3f5e",
"page_012.png": "sha256:73e4cef5b11b85111f41783448e1efda2ea16b34d9b59cc75eb2b2192e9c9302",
"page_013.png": "sha256:11d457c2a591f45aceb486ebc8ef5b262dbe4f29f5704ce1a8005dbc786a875f",
"page_014.png": "sha256:c4067c4bc4c38c9bef9fbef689ad194053fb55ac79a8ee06751fce5c8b1e9cff",
"page_015.png": "sha256:49afc87f22fc6e5d54d2a5cd7af6d3f02ee692a43684a0b77428424accb3389b",
"page_016.png": "sha256:6ec51ee19a8ea05170388bbf34e38084d51d42bb1519622248ae0d3181a710b4",
"page_017.png": "sha256:9d765a89531f516147801b787b12e5da4d260642de8232cc9b8f41ab9cc7a587",
"page_018.png": "sha256:6d2ad2f1a5e86d2399165b669911d610df2620b83b3003d02908cf122cc5905c",
"page_019.png": "sha256:e7afbfd01d193c04c50c551d7e0aafa26bdf8a2f03101abb6105d3758ef4bac9",
"page_020.png": "sha256:c9b03e3e29e095361e4d7f612137d64a7b66b73dcaa1f884ebbddf95f96db1d8",
"page_021.png": "sha256:030d2aa1e6deb81ac7ac535ad92d49b4a569d0549716adcec95130d470f99352",
"page_022.png": "sha256:38ea5f6dd2c64536c4ae2d202009d56f726f0337255ff62ea73da82edc5d3ec2",
"page_023.png": "sha256:d419b618d590ab3d62adcfd15aa38ba9912607d80108750d312d3052096f7418",
"page_024.png": "sha256:78a71526fefcb597f61016ace008002eed667aad09bf5062aa979a511bd59a74",
"page_025.png": "sha256:10b4e21dedf0bfe1de7d4cb99927b385882846d6b454bcf26f412908c7c51d35",
"page_026.png": "sha256:2fda4afa83b0feaa1aa87b3def9be6bbae6b7b05edfab40fdb32330d495dda07",
"page_027.png": "sha256:fef1883e6b3149818eaf31e5e18b1266875d4e826ff7af816b2156f8b3b2ff17"
}
},
"artifact_freshness": {
"missing": [],
"mismatches": [
"document_structure older than blocks_structured",
"figure_inventory older than blocks_structured",
"table_inventory older than blocks_structured",
"resolved_metadata older than blocks_structured"
],
"annotated_pages_rendered": [
"page_001.png",
"page_002.png",
"page_003.png",
"page_004.png",
"page_005.png",
"page_006.png",
"page_007.png",
"page_008.png",
"page_009.png",
"page_010.png",
"page_011.png",
"page_012.png",
"page_013.png",
"page_014.png",
"page_015.png",
"page_016.png",
"page_017.png",
"page_018.png",
"page_019.png",
"page_020.png",
"page_021.png",
"page_022.png",
"page_023.png",
"page_024.png",
"page_025.png",
"page_026.png",
"page_027.png"
]
},
"reviewed_pages": [
1,
3,
4,
6,
9,
10,
12,
13,
15,
17,
19,
21,
23,
26,
27
],
"reviewed_blocks": [
"p1:0",
"p1:1",
"p1:2",
"p1:3",
"p1:4",
"p1:5",
"p1:6",
"p1:7",
"p1:8",
"p1:9",
"p1:10",
"p1:11",
"p1:12",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p3:0",
"p3:1",
"p3:2",
"p3:3",
"p3:4",
"p3:5",
"p3:6",
"p3:7",
"p3:8",
"p3:9",
"p3:10",
"p3:11",
"p3:12",
"p4:0",
"p4:1",
"p4:2",
"p4:3",
"p4:4",
"p4:5",
"p4:6",
"p4:7",
"p4:8",
"p4:9",
"p4:10",
"p4:11",
"p4:12",
"p4:13",
"p4:14",
"p4:15",
"p4:16",
"p4:17",
"p4:18",
"p4:19",
"p4:20",
"p4:21",
"p4:22",
"p4:23",
"p4:24",
"p4:25",
"p4:26",
"p4:27",
"p4:28",
"p4:29",
"p6:0",
"p6:1",
"p6:2",
"p6:3",
"p6:4",
"p6:5",
"p6:6",
"p6:7",
"p6:8",
"p6:9",
"p6:10",
"p6:11",
"p6:12",
"p6:13",
"p9:0",
"p9:1",
"p9:2",
"p9:3",
"p9:4",
"p9:5",
"p9:6",
"p9:7",
"p9:8",
"p9:9",
"p9:10",
"p9:11",
"p9:12",
"p9:13",
"p9:14",
"p9:15",
"p9:16",
"p9:17",
"p9:18",
"p9:19",
"p9:20",
"p9:21",
"p9:22",
"p9:23",
"p9:24",
"p9:25",
"p9:26",
"p9:27",
"p9:28",
"p9:29",
"p9:30",
"p9:31",
"p9:32",
"p10:0",
"p10:1",
"p10:2",
"p10:3",
"p10:4",
"p10:5",
"p10:6",
"p10:7",
"p10:8",
"p10:9",
"p10:10",
"p10:11",
"p12:0",
"p12:1",
"p12:2",
"p12:3",
"p12:4",
"p12:5",
"p12:6",
"p12:7",
"p12:8",
"p12:9",
"p12:10",
"p12:11",
"p12:12",
"p12:13",
"p12:14",
"p12:15",
"p12:16",
"p12:17",
"p12:18",
"p12:19",
"p12:20",
"p12:21",
"p13:0",
"p13:1",
"p13:2",
"p13:3",
"p13:4",
"p13:5",
"p13:6",
"p13:7",
"p13:8",
"p13:9",
"p13:10",
"p13:11",
"p13:12",
"p13:13",
"p13:14",
"p13:15",
"p13:16",
"p13:17",
"p13:18",
"p13:19",
"p13:20",
"p13:21",
"p13:22",
"p13:23",
"p13:24",
"p13:25",
"p13:26",
"p13:27",
"p13:28",
"p13:29",
"p13:30",
"p13:31",
"p13:32",
"p13:33",
"p13:34",
"p13:35",
"p13:36",
"p13:37",
"p13:38",
"p13:39",
"p13:40",
"p13:41",
"p13:42",
"p13:43",
"p15:0",
"p15:1",
"p15:2",
"p15:3",
"p15:4",
"p15:5",
"p15:6",
"p15:7",
"p15:8",
"p15:9",
"p15:10",
"p15:11",
"p15:12",
"p15:13",
"p15:14",
"p15:15",
"p15:16",
"p15:17",
"p15:18",
"p15:19",
"p15:20",
"p15:21",
"p15:22",
"p15:23",
"p15:24",
"p15:25",
"p15:26",
"p15:27",
"p15:28",
"p15:29",
"p15:30",
"p15:31",
"p15:32",
"p17:0",
"p17:1",
"p17:2",
"p17:3",
"p17:4",
"p17:5",
"p17:6",
"p17:7",
"p17:8",
"p17:9",
"p17:10",
"p17:11",
"p17:12",
"p17:13",
"p17:14",
"p17:15",
"p19:0",
"p19:1",
"p19:2",
"p19:3",
"p19:4",
"p19:5",
"p19:6",
"p19:7",
"p19:8",
"p19:9",
"p19:10",
"p19:11",
"p19:12",
"p21:0",
"p21:1",
"p21:2",
"p21:3",
"p21:4",
"p21:5",
"p21:6",
"p21:7",
"p21:8",
"p21:9",
"p21:10",
"p21:11",
"p21:12",
"p21:13",
"p21:14",
"p21:15",
"p21:16",
"p21:17",
"p21:18",
"p21:19",
"p21:20",
"p21:21",
"p23:0",
"p23:1",
"p23:2",
"p23:3",
"p23:4",
"p23:5",
"p23:6",
"p23:7",
"p23:8",
"p23:9",
"p23:10",
"p23:11",
"p23:12",
"p23:13",
"p23:14",
"p23:15",
"p23:16",
"p23:17",
"p23:18",
"p23:19",
"p23:20",
"p23:21",
"p23:22",
"p23:23",
"p23:24",
"p23:25",
"p23:26",
"p23:27",
"p23:28",
"p23:29",
"p23:30",
"p23:31",
"p23:32",
"p23:33",
"p23:34",
"p23:35",
"p23:36",
"p23:37",
"p23:38",
"p23:39",
"p23:40",
"p23:41",
"p23:42",
"p23:43",
"p23:44",
"p23:45",
"p23:46",
"p23:47",
"p23:48",
"p23:49",
"p23:50",
"p23:51",
"p23:52",
"p23:53",
"p23:54",
"p23:55",
"p23:56",
"p23:57",
"p23:58",
"p23:59",
"p26:0",
"p26:1",
"p26:2",
"p26:3",
"p26:4",
"p26:5",
"p26:6",
"p26:7",
"p26:8",
"p26:9",
"p26:10",
"p26:11",
"p26:12",
"p26:13",
"p26:14",
"p26:15",
"p26:16",
"p26:17",
"p26:18",
"p26:19",
"p26:20",
"p26:21",
"p26:22",
"p26:23",
"p26:24",
"p26:25",
"p26:26",
"p26:27",
"p26:28",
"p27:0",
"p27:1",
"p27:2",
"p27:3",
"p27:4",
"p27:5",
"p27:6",
"p27:7",
"p27:8",
"p27:9",
"p27:10",
"p27:11",
"p27:12"
],
"findings": [
{
"category": "same_page_boundary_error",
"severity": "major",
"block_ids": [],
"truth": "body/reference/backmatter boundaries should be explainable at block level",
"pipeline_behavior": "page contains mixed body/reference/tail signals",
"root_cause_hypothesis": "same-page boundary ambiguity",
"evidence": {
"annotated_page": "annotated_pages/page_023.png",
"artifact": "page_risk_summary.json"
}
},
{
"category": "render_mapping_error",
"severity": "minor",
"block_ids": [
"p1:0",
"p1:2",
"p1:3",
"p1:8",
"p1:13",
"p1:14",
"p1:15",
"p1:16",
"p2:0",
"p2:2",
"p2:3",
"p2:4",
"p2:6",
"p2:12",
"p2:13",
"p2:14",
"p2:15",
"p3:0",
"p3:4",
"p3:9"
],
"truth": "rendered fulltext should be traceable back to source blocks",
"pipeline_behavior": "some render-default blocks are not easily mapped into the current fulltext output",
"root_cause_hypothesis": "render omission or snippet mismatch",
"evidence": {
"annotated_page": null,
"artifact": "fulltext_block_mapping_summary.json"
}
}
]
}

Some files were not shown because too many files have changed in this diff Show more